Avail a detailed research offering a comprehensive analysis of the developments, growth outlook, driving factors, and key players of the Recombinant Human Serum Albumin market in the latest research report added by Big Market Research.The recent research report on the global Recombinant Human Serum Albumin Market presents the latest industry data and future trends, allowing you to recognize the products and end users driving Revenue growth and profitability of the market.. The report offers an extensive analysis of key drivers, leading market players, key segments, and regions. Besides this, the experts have deeply studied different geographical areas and presented a competitive scenario to assist new entrants, leading market players, and investors determine emerging economies. These insights offered in the report would benefit market players to formulate strategies for the future and gain a strong position in the global market. Request a sample of this premium research: ...
Our study does not provide evidence that the effect of resuscitation with albumin compared with saline in the intensive care unit is different in patients with different baseline serum albumin concentrations. Nor does it provide evidence to support the suggestion that albumin increases the risk of mortality in patients with hypoalbuminaemia. When the odds ratios for death was compared in patients with a baseline serum albumin concentration of 25 g/l or less or of more than 25 g/l we found only limited evidence that treatment effects were different and this only after correction for other baseline risk factors. When we considered the effect of baseline serum albumin concentration as a continuous variable across the spectrum of albumin concentrations, baseline concentration had no impact on the treatment effect even after correction for other baseline risk factors. Taken together these results suggest that albumin and saline produce similar treatment effects across the range of albumin ...
Sarver R.W., Gao H., Tian F.. An NMR method was developed for determining binding sites of small molecules on human serum albumin (HSA) by competitive displacement of (13)C-labeled oleic acid. This method is based on the observation that in the crystal structure of HSA complexed with oleic acid, two principal drug-binding sites, Sudlows sites I (warfarin) and II (ibuprofen), are also occupied by fatty acids. In two-dimensional [(1)H,(13)C]heteronuclear single quantum coherence NMR spectra, seven distinct resonances were observed for the (13)C-methyl-labeled oleic acid as a result of its binding to HSA. Resonances corresponding to the major drug-binding sites were identified through competitive displacement of molecules that bind specifically to each site. Thus, binding of molecules to these sites can be followed by their displacement of oleic acids. Furthermore, the amount of bound ligand at each site can be determined from changes in resonance intensities. For molecules containing fluorine, ...
The purpose of this study is to evaluate the dosages of recombinant human serum albumin/granulocyte colony-stimulating factor fusion protein by injection for
Clinical epidemiologists will be interested in the study by Corti and colleagues. Although the association between hypoalbuminemia and mortality has been examined before, this study has many strengths common to work coming from the EPESE. The data are from a population-based cohort study in which participants were followed for several years. The investigators had data on serum albumin, functional ability, chronic disease, and both disease-specific and all-cause mortality. Clinical investigators should also be interested in this study. The finding that serum albumin level is an independent risk factor for mortality should encourage its inclusion as a variable in many studies of elderly persons, especially in clinical trials that use mortality as an end point. Investigators in clinical trials should also consider adding simple measures of disability to data on albumin to create a more powerful measure of frailty and risk for mortality. In particular, trials using interventions such as exercise, ...
Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis? Abdurrahman Sahin,1 Semra Turkoglu,2 Nurettin Tunc,1 Deccane Duzenci,3 Ozgen Arslan Solmaz,4 Ibrahim Halil Bahcecioglu,1 Mehmet Yalniz1 1Medicine Faculty, Department of Gastroenterology, Firat University, Elazig, Turkey; 2Department of Nutrition and Dietetics, Health Sciences Faculty, Firat University, Elazig, Turkey; 3Department of Internal Medicine, Elazig Education and Training Hospital, Elazig, Turkey; 4Department of Pathology, Elazig Education and Training Hospital, Elazig, Turkey Purpose: Oxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP.Patients and methods: A
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Ischemia-modified albumin (IMA) is assumed “N-terminal modified” albumin which is generated immediately following myocardial ischemia. The diagnosis of IMA is based on reduced cobalt binding affinity to albumin which is attributed mainly to incapability of cobalt to bind at albumin’s modified N-terminus. Although the albumin cobalt binding test was accepted as a potentially powerful marker for discriminating acute coronary syndrome from nonischemic chest pain, its usefulness has been brought into question in recent years. Patients with acutely ischemic myocardium exhibit a rapid increase in serum levels of fatty acids (FAs). Almost all released FAs are strongly bound to albumin which create conformational changes in the protein with resultant reduced cobalt binding affinity. There is a clear metabolic and temporal relationship between IMA measured via albumin cobalt binding testing and serum levels of FAs. In line with what has been suggested recently in the literature, we conclude
Background: Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels.. Materials and Methods: We studied 118 consecutive patients presenting within 3 h of the onset of an acute neurological deficit [84 brain infarctions (BI), 18 brain hemorrhages (ICH) and 16 transient ischemic attacks lasting less than 1 h or epileptic seizures]. Serum samples were obtained for all patients at initial presentation and repeated only in patients with stroke at 6, 12 and 24 h. IMA was measured by the albumin-cobalt-binding test (Ischemia Technologies, Denver, Colo., USA). Results: The initial median IMA (bootstrap 95% confidence interval, CI) was 83 U/ml (79-86) and 86 U/ml (75-90) in patients with BI and ICH, respectively (p = 0.76), and was 73 U/ml (58-79) in others (p = 0.003 compared with BI, and p = 0.017 with ICH). Baseline IMA ...
TY - JOUR. T1 - A liposome reversibly coated with serum albumin. AU - Sato, Hikari. AU - Nakamura, Yuta. AU - Nakhaei, Elnaz. AU - Funamoto, Daiki. AU - Kim, Chan Woo. AU - Yamamoto, Tatsuhiro. AU - Kishimura, Akihiro. AU - Mori, Takeshi. AU - Katayama, Yoshiki. PY - 2014. Y1 - 2014. N2 - Herein, we reported a design of liposome affording a reversible coating of serum albumin on its surface. We synthesized a lipid modified with a serum albumin-specific endogenous ligand and prepared liposome, including this lipid. We successfully confirmed the coating of the liposome surface with serum albumin. The liposome presented here would be applicable to a drug carrier with enhanced blood circulation.. AB - Herein, we reported a design of liposome affording a reversible coating of serum albumin on its surface. We synthesized a lipid modified with a serum albumin-specific endogenous ligand and prepared liposome, including this lipid. We successfully confirmed the coating of the liposome surface with serum ...
1. The labelling of intracellular and extracellular serum albumin was studied in liver slices and in whole rats by using new methods for the purification of the protein. 2. The results suggest that a polypeptide precursor is formed that is converted relatively slowly into serum albumin. 3. The effect of liver cell K+has been examined by a double-label method and it is shown that K+accelerates the rate of conversion of precursor into albumin. The rate of transit of albumin across the cell membrane appears to be unrelated to the concentration of K+within the cell. 4. The time-course of incorporation of radioactive amino acid into albumin follows a sigmoidal mode. There is a pronounced time-lag before label starts to appear in intracellular albumin, and a further time-lag before it appears in extracellular albumin. 5. In slices the sum of intra- and extra-cellular label rises steadily from 30min after the start of labelling with a pulse of labelled leucine or valine and continues to rise for at ...
Catalog Number: 135-MSA-0100. Category: Serum. Supplier: Equitech Bio. Species: Mouse. To order Mouse Serum Albumin Lyophilized Powder from Equitech Bio Contact [email protected] ...
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Export Data And Price Of Human Albumin 20 100 Ml , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of Human Albumin 20 100 Ml Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India Human Albumin 20 100 Ml Export data. You can find previous two days Human Albumin 20 100 Ml Export data on Eximpulse Services. Human Albumin 20 100 Ml Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for Human Albumin 20 100 Ml Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected] Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian ...
Healthy volunteers in the postabsorptive state (n = 10), patients with acute inflammatory abdominal disease and plasma C-reactive protein over 100 mg/L (n = 10), and patients scheduled for elective pancreatic resection at the beginning of surgical procedure (n = 10) were studied. The albumin synthesis rate was measured by the flooding dose technique comprising the incorporation of deuterium-labeled phenylalanine in de novo synthesized albumin determined by a gas chromatography mass spectrometer.[1] Total albumin pool was determined by measuring plasma volume using 125I-albumin and plasma albumin concentrations. The 3 groups were compared by means of one-way analysis of variance. ...
TY - JOUR. T1 - Insights into the molecular interaction between two polyoxygenated cinnamoylcoumarin derivatives and human serum albumin. AU - Khammari, Anahita. AU - Saboury, Ali Akbar. AU - Karimi-Jafari, Mohammad Hossein. AU - Khoobi, Mehdi. AU - Ghasemi, Atiyeh. AU - Yousefinejad, Saeed. AU - Abou-Zied, Osama K.. PY - 2017. Y1 - 2017. N2 - Ligand binding studies on human serum albumin (HSA) are crucial in determining the pharmacological properties of drug candidates. Here, two representatives of coumarin-chalcone hybrids were selected and their binding mechanism was identified via thermodynamics techniques, curve resolution analysis and computational methods at molecular levels. The binding parameters were derived using spectroscopic approaches and the results point to only one pocket located near the Trp214 residue in subdomain IIA of HSA. The protein tertiary structure was altered during ligand binding and formed an intermediate structure to create stronger ligand binding interactions. The ...
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Valor de la albúmina sérica en niños admitidos en una unidad de cuidados intensivos / Serum albumin value in children admitted in an intensive care unit
Albumin is the primary component of plasma proteins and accounts for 80% of colloid osmotic pressure. Its three domains determine the binding properties for several endogenous molecules and drugs. The cystein -SH residue accounts for its antioxidant properties and binding of nitric oxide, modulating its effect. The imidazole residues of 16 istidine molecules make albumin the most powerful buffer in the extravascular space. Plasma albumin concentration is a powerful dose-dependent predictor of mortality. Three relevant subsequent metanalysis, in sequence, found albumin administration harmful, neutral and advantageous. The blind, controlled and randomized SAFE study, performed in a large Intensive Care population, found similar outcomes in patient treated with 4% albumin or crystalloids for fluid resuscitation. The subgroup analysis showed a beneficial trend in septic patients treated with albumin and unfavourable trend in trauma patients with brain injury. Unfortunately albumin has been mainly ...
Albumin is a blood protein. The word "albumin" comes from the Latin for egg white (egg white contains albumin, which is one reason why eggs are a rich source of protein). Albumin is produced in the liver. It is important in the maintenance of blood consistency and regulating blood pressure, and in the transmission of certain nutrients through the bloodstream. Its reasonable to say that this is a very important substance in the blood.. Test. A test for albumin is useful in the diagnosis of many different illnesses. Low levels of albumin can be an indicator of kidney dysfunction. Thats because healthy kidneys that are functioning properly leave albumin in the blood for the most part while removing waste substances. A low serum albumin level combined with the detection of higher than normal levels of albumin in urine shows that the kidneys are not doing this properly.. Causes. Other causes of low albumin include certain liver diseases such as liver cancer or hepatitis. This can interfere with the ...
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Learn more about Bovine Serum Albumin (Fraction V) and get the best prices in the life science marketplace at AG Scientific, Inc. We have over 20 years of experience with biochemical supplies that were excited to share with you!
Albumins are a group of acidic proteins which occur plentifully in the body fluids and tissues of mammals and in some plant seeds. Unlike globulins, albumins have comparatively low molecular weights, are soluble in water, are easily crystallized, and contain an excess of acidic amino acids. Serum and plasma albumin is carbohydrate-free and comprises 55-62% of the protein present.. Albumin binds water, Ca2+, Na+, and K+. Due to a hydrophobic cleft, albumin binds fatty acids, bilirubin, hormones, and drugs. The main biological function of albumin is to regulate the colloidal osmotic pressure of blood. Human and bovine albumins contain 16% nitrogen and are often used as standards in protein calibration studies. Albumin is used to solubilize lipids, and is also used as a blocking agent in Western blots or ELISA applications. Globulin free albumins are suitable for use in applications where no other proteins should be present (e.g., electrophoresis).. ...
TY - JOUR. T1 - Glycated albumin at 4 weeks correlates with a1c levels at 12 weeks and reflects short-term glucose fluctuations. AU - Desouza, Cyrus V. AU - Rosenstock, Julio. AU - Zhou, Rong. AU - Holcomb, Richard G.. AU - Fonseca, Vivian A.. PY - 2015/11. Y1 - 2015/11. N2 - Objective: Evaluate the performance of glycated albumin (GA) monitoring by comparing it to other measures of glycemic control during intensification of antidiabetic therapy. Methods: This 12-week, prospective, multicenter study compared the diagnostic clinical performance of GA to glycated hemoglobin A1C (A1C), fructosamine corrected for albumin (FRA), fasting plasma glucose (FPG), and mean blood glucose (MBG) estimated from self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) in 30 patients with suboptimally controlled type 1 or 2 diabetes. Results: Mean A1C decreased from 9.5% to 8.1%. Mean SMBG correlated closely with CGM (Pearson r = 0.783 for daily estimates and r = 0.746 for weekly ...
GenWay offers the human serum albumin depletion column to dig deeper into the proteome. Visit the GenWay website to learn more about the human serum albumin depletion column and other serum protein depletion column products currently available.
Albumin is the most abundant plasmatic protein. It is only produced by the liver and the full extent of its metabolic functions is not known in detail. One of the main roles assigned to albumin is as an indicator of malnutrition. There are many factors, in addition to nutrition, that influence levels of albumin in plasma. The main aim of this review is to assess the clinical significance of albumin in elderly people in the community, in hospital and in care homes. Following the review, it can be stated that age is not a cause of hypoalbuminemia. Albumin is a good marker of nutritional status in clinically stable people. Significant loss of muscle mass has been observed in elderly people with low albumin levels. Hypoalbuminemia is a mortality prognostic factor in elderly people, whether they live in the community or they are in hospital or institutionalized. Low levels of albumin are associated to worse recovery following acute pathologies. Inflammatory state and, particularly, high concentrations of IL
TY - JOUR. T1 - Heterogeneity of igE epitopes of vinyl sulphone reactive dye. T2 - Human serum albumin that react with igE. AU - Park, J. W.. AU - Kang, D. B.. AU - Choi, S. Y.. AU - Kim, C. W.. AU - Kim, K. S.. AU - Hong, C. S.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - Background: Vinyl sulphone reactive dye (vRD), which consists of vinyl sulphone reactive groups and a chromogen, can elicit IgE-mediated occupational asthma (OA) by haptenation. Human serum albumin (HSA) is known as the most reliable carrier protein for the vRD, the IgE epitopes of vRD-HSA are not well characterized. In this study we evaluated the epitope of vRD-HAS-specific IgE. Methods: Two vRD (Remazole Black-GR and Remazole Orange-3R), Procion Red-MX-5B, which has a dichlorotriazine reactive group, and vinyl sulphone (VS), were haptenated to HSA, respectively. vRD-HSA was denatured by heat or mercaptoethanol treatment and the allergenicities of denatured and non-denatured vRD-HSA were compared by ELISA and IgE immunoblotting ...
Serum albumin is the most abundant plasma protein and has a long half-life due to neonatal Fc receptor (FcRn)-mediated transcytosis by many cell types, including proximal tubule cells of the kidney. Albumin also interacts with, and is modified by, many small and large molecules. Therefore, the focus of the present study was to address the impact of specific known biological albumin modifications on albumin-FcRn binding and cellular handling. Binding at pH 6.0 and 7.4 was performed since FcRn binds albumin strongly at acidic pH and releases it after transcytosis at physiological pH. Equilibrium dissociation constants were measured using microscale thermophoresis. Since studies have shown that glycated albumin is excreted in the urine at a higher rate than unmodified albumin, we studied glucose and methylgloxal modified albumins (21 days). All had reduced affinity to FcRn at pH 6.0, suggesting these albumins would not be returned to the circulation via the transcytotic pathway. To address why ...
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Cellastim S is recombinant human serum albumin that is completely blood-free and has been optimized specifically to enhance the performance in animal-free cell culture media due to the favorable lipid profile and other engineered attributes of the molecule. Cellastim S is ideally suited for a variety of different stem, primary, and production cell types that include immune cells, VERO, Mesenchymal Stem Cells, HEK, CHO and other cell types. Each lot tested in cell culture systems to ensure consistent quality and performance.. ...
Can f 3, also known as Dog Serum Albumin (DSA), is a protein with a molecular weight of 69-70 kDa. It is a serum albumin. It is found in dog serum, saliva, dander, hair and epithelia, and it is also synthesised in the dog salivary gland and dog liver. (37) Dog serum albumin has been reported to be a particularly abundant allergen in dog epithelia extracts. (55) Dog and cat serum albumins are also allergens very commonly present in house dust. (44) A recombinant Can f 3 has been produced. (37). Sensitisation to dog serum albumin has previously been documented as varying from around 35-48%, although early studies reported even lower frequencies. (5, 28, 33, 59) The importance and frequency of sensitisation to DSA also varies in different populations. (3). In a study, 51 patients with a clinical history of dog allergy were evaluated for skin-specific IgE for 8 individual, standardised dog breed allergen preparations, and for 1 mixed-breed allergen preparation, dog serum albumin, and histamine ...
Purpose: Dysfunction of the blood-brain barrier (BBB) is a common finding during seizures or following epileptogenic brain injuries, and experimentally induced BBB opening promotes seizures both in naive and epileptic animals. Brain albumin extravasation was reported to promote hyperexcitability by inducing astrocytes dysfunction. To provide in vivo evidence for a direct role of extravasated serum albumin in seizures independently on the pathologic context, we did the following: (1) quantified the amount of serum albumin extravasated in the rat brain parenchyma during status epilepticus (SE); (2) reproduced a similar concentration in the hippocampus by intracerebroventricular (i.c.v.) albumin injection in naive rats; (3) measured electroencephalography (EEG) activity in these rats, their susceptibility to kainic acid (KA)-induced seizures, and their hippocampal afterdischarge threshold (ADT). Methods: Brain albumin concentration was measured in the rat hippocampus and other forebrain regions 2 ...
Considering the importance of pharmacology and the influence of drugs on biological materials, the effects of a newly designed and synthesized platin complex (2,2′-Bipyridine-3,3′-dicarboxylic acid,...
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|b||i|Objectives:|/i||/b| This study aimed to compare the value of serum glycated albumin (GA) level versus glycated hemoglobin A1c (HbA1c) for evaluating
HRP偶联Human Serum Albumin抗体(ab8941)可与人样本反应并经ELISA实验严格验证,实验条件参看说明书。Abcam对所有产品均提供质保服务和专属技术支持,中国75%以上现货。
According to WebMD, a normal albumin level is 3.5 to 5.0 grams per deciliter, or 35 to 50 grams per liter. This level is determined by a blood...
Development of cancer treatment regimens including immunotoxins is partly hampered by their immunogenicity. Recently, deimmunized versions of toxins have been described, potentially being better suited for translation to the clinic. In this study, a recombinant tripartite fusion toxin consisting of a deimmunized version of exotoxin A from Pseudomonas aeruginosa (PE38) genetically fused to an affibody molecule specifically interacting with the human epidermal growth factor receptor 2 (HER2), and also an albumin binding domain (ABD) for half-life extension, has been produced and characterized in terms of functionality of the three moieties. Biosensor based assays showed that the fusion toxin was able to interact with human and mouse serum albumin, but not with bovine serum albumin and that it interacted with HER2 (K-D=5 nM). Interestingly, a complex of the fusion toxin and human serum albumin also interacted with HER2 but with a somewhat weaker affinity (K-D=12 nM). The IC50-values of the fusion ...
View Notes - Chapter 34 from BIO 103 at Northeastern. Cardiac Output = HR X SV 5/7/09 Human Blood Plasma- 92% Water- 8% Plasma Proteins Albumin, Globulins Fibrin, etc. Formed Elements- Erythrocytes
In the final sentence of the item headed "Baseline serum albumin concentrations do not affect resuscitation outcomes" we wrongly wrote that "Rates of admission to intensive care and renal replacement therapy, and length of mechanical ventilation and hospital stay did not differ between groups" (BMJ 2006;333, 18 Nov, doi: 10.1136/bmj.333.7577.0-b). In fact, we should have said: "The relative risk of death with albumin or saline was similar, regardless of patients baseline serum albumin concentration." ...
The aim of this work was to evaluate the ability of oxidative and glycative stressors to modify properties of human serum albumin (HSA) by analyzing markers of glycation (pentosidine) and oxidation (advanced oxidative protein products (AOPPs)) and assessing fluorescence and circular dichroism. HSA was incubated for up to 21 days with ribose, ascorbic acid (AA) and diethylenetriamine pentacetate (DTPA) in various combinations in order to evaluate influences of these substances on the structure of HSA. Ribose was included as a strong glycative molecule, AA as a modulator of oxidative stress, and DTPA as an inhibitor of metal-catalyzed oxidation. Ribose induced a significant increase in pentosidine levels. AA and DTPA prevented the accumulation of pentosidine, especially at later time points. Ribose induced a mild increase in AOPP formation, while AA was a strong inducer of AOPP formation. Ribose, in combination with AA, further increased the formation of AOPP. DTPA prevented the AA-induced generation of
HSA/human Serum albumin peptide Isotype Control, 0.1 ml. Isotype controls are negative controls that are designed to measure the amount of non-specific background signal caused by the primary antibody.
Human serum albumin (HSA), the most abundant plasma protein in human blood, is a natural transport vehicle with multiple ligand binding sites. It, therefore, constitutes an attractive candidate for drug delivery. Targeting may occur via the most known interaction of the protein with the neonatal Fc receptor
SeraCares Human Serum Albumin, or HSA, is designed for use in IVD diagnostic reagents or cell culture applications. HSA is manufactured from plasma that has tested negative for infectious diseases and are available in liquid or powder format.
Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.
Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia , and Saccharomyces to manufacture and distribute both research grade as well as custom bulk manufacturing grades. Both powders and solutions are available providing high purity and cell culture-tested versions.

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Human Serum Albumin Polyclonal Antibody from Invitrogen for Western Blot, ELISA, Immunodiffusion and Immunoelectrophoresis applications. This antibody reacts with Human samples. Supplied as 200 µg purified antibody in PBS with 0.02% sodium azide; pH 7.4.
WHITE PHARMACEUTICALS - Exporter, Importer, Distributor, Supplier, Trading Company of Human Normal Albumin IP based in New Delhi, India
SeraCare is a trusted partner and worldwide supplier to the diagnostic testing industry, advancing the development of clinical genomics, molecular, and serological diagnostics. Check out how our product, Human Serum Albumin, Fatty Acid Free, Powder 5 KG can help with research, development, validation, and lab testing.