Results Mean age was 50 years (6-89), 65% female. Prior colonoscopy was recorded in 76%, blood tests in 89%. Only 27% of patients had an IBS diagnosis reported. Overall, the centre-defined normal retention was seen in 47% of cases, and abnormal retention in 43%, the rest being considered borderline. Suspected Type 1 (BAM secondary to ileal resection/disease) was the smallest group (14%). Of these, 83% had Crohns disease and 64% had an ileal resection. SeHCAT retention was predictably low: mean 9%, (SD 13%), median 2%. The largest group (44%) with suspected Type 2 (idiopathic/primary BAM), had a mean retention of 21% (SD 17%), median 18%. In suspected Type 3 (41%; BAM secondary to various gastrointestinal diseases) mean retention was 22% (SD 20%), median 17%. Of these ​34% were post-cholecystectomy and 12% were diabetic. ...
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Eubacterium acidaminophilum GrdD protein: Cys359 of GrdD is the active-site thiol that catalyses the final step of acetyl phosphate formation by glycine reductase from Eubacterium acidaminophilum; GenBank L04500
2YAU: A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition.
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Evidence-based recommendations on SeHCAT (tauroselcholic [75 selenium] acid) for investigating diarrhoea due to bile acid malabsorption (BAM)
Albireo is developing A3384 to treat bile acid malabsorption disease (BAM), which has no approved treatment options. Learn about the clinical trial and more.
The HORTINLEA project started in July 2013 and runs for three years with a total budget of approximately 1.5 million euros per year. Two additional ye... ...
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A review of disorders of selenium metabolism and selenoproteins was recently publised in Current Opinion in Pediatrics. It includes up to date descriptions of SECISBP2 syndrome, causing thyroid dysfunction and growth retardation, and SEPSECS mutations causing progressive cerebellar and cerebral atrophy. Other abnormalities seen in impaired selenium metabolism include impaired muscle function, and immune deficits.. (Schweizer et al, Current Opinion in Pediatrics, 2011, 23:June 8, epub.). Posted by Hilary Vernon MD PhD. ...
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TY - JOUR. T1 - Remission of bile acid malabsorption symptoms following treatment with the glucagon-like peptide 1 receptor agonist liraglutide. AU - Kårhus, Martin L. AU - Brønden, Andreas. AU - Røder, Michael E. AU - Leotta, Salvatore. AU - Sonne, David P. AU - Knop, Filip K. PY - 2019/8/1. Y1 - 2019/8/1. KW - Aged. KW - Bile Acids and Salts/metabolism. KW - Diabetes Mellitus, Type 2/complications. KW - Female. KW - Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors. KW - Humans. KW - Liraglutide/pharmacology. KW - Malabsorption Syndromes/drug therapy. KW - Male. KW - Middle Aged. KW - Overweight/complications. KW - Remission Induction/methods. KW - Treatment Outcome. UR - http://www.scopus.com/inward/record.url?scp=85069552243&partnerID=8YFLogxK. U2 - 10.1053/j.gastro.2019.04.002. DO - 10.1053/j.gastro.2019.04.002. M3 - Journal article. VL - 157. SP - 569. EP - 571. JO - Gastroenterology. JF - Gastroenterology. SN - 0016-5085. IS - 2. ER - ...
Aliment Pharmacol Ther. 2009 Oct;30(7):707-17. doi: 10.1111/j.1365-2036.2009.04081.x. Epub 2009 Jun 30. Research Support, Non-U.S. Govt; Review
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wang H, Zhang J, Yu H; Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia ...
Wang H, Zhang J, Yu H; Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia ...
Compare Selenoprotein P ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Have you ever wondered why some people seem to get all the benefits they are supposed to get from exercise--like feeling energized, losing weight, building more toned and defined muscles, etc.--while others exercise the same amount and see no change? Are you frustrated with the way your work out regimen doesnt seem to be making any difference in your lifestyle or your look? If so, it might have less to do with your routine and more to do with your proteins. What Is Selenoprotein P? Selenoprotein P is, according to a 2005 study published in the medical journal Annual Review […]. Read more » ...
Visualized by Rapid Freeze Quench and Selenium EXAFS of Se-Labeled Metallochaperones. A Paradigm for Studying Copper-Mediated Host-Pathogen Interactions. Mammalian hosts defend against invading pathogens via the import of toxic concentrations of copper into the phagolysosome. To combat this host-defense strategy, gram negative pathogens respond via sophisticated copper export systems which are able to neutralize the…
Professional guide for Auranofin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
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The research group of Dr. Norman Metanis, from the Institute of Chemistry, specializes in organic and bioorganic chemistry and has recently published an article in Chemical Science, in which they describe for the first time a method to access human selenoproteins by total chemical protein synthesis. The human body contains 25 selenoproteins, which contain in their sequence the twenty-first encoded amino acid, selenocysteine. About a dozen of these proteins remain functionally uncharacterized or poorly studied. Challenges in accessing these selenoproteins using traditional recombinant expressions have prevented biological characterization thus far. The Metanis group reported the total chemical syntheses of two human selenoproteins, selenoprotein M (SELM) and selenoprotein W (SELW). The synthesis of the more challenging protein SELM, which is longer, was enabled using recent advances in the field of selenocysteine chemistry that was developed in the lab. This approach allows the preparation of ...
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
Abstract: The genomes of both bacteria and eukaryotic organisms are known to encode selenoproteins, using the UGA codon for selenocysteine (SeC), and a complex cotranslational mechanism for SeC incorporation into polypeptide chains, involving RNA stem-loop structures. These common features and similar codon usage strongly suggest that this is an ancient evolutionary development. However, the possibility that some viruses might also encode selenoproteins remained unexplored until recently. Based on an analysis of the genomic structure of the human immunodeficiency virus HIV-1, we demonstrated that several regions overlapping known HIV genes have the potential to encode selenoproteins (Taylor et al.[31], J. Med. Chem. 37, 2637-2654 [1994]). This is provocative in the light of over-whelming evidence of a role for oxidative stress in AIDS pathogenesis, and the fact that a number of viral diseases have been linked to selenium (Se) deficiency, either in humans or by in vitro and animal studies. These ...
The trace element selenium is an essential micronutrient that is required for the biosynthesis of selenocysteine-containing selenoproteins. Most of the known selenoproteins are expressed in the thyroid gland, including some with still unknown functions. Among the well-characterized selenoproteins ar …
Obeticholic acid (abbreviated to OCA, trade name Ocaliva), is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid. It is used as a drug to treat primary biliary cholangitis, and is undergoing development for several other liver diseases and related disorders. Intercept Pharmaceuticals Inc. hold the worldwide rights to develop OCA outside Japan and China, where it is licensed to Dainippon Sumitomo Pharma. The natural bile acid, chenodeoxycholic acid, was identified in 1999 as the most active physiological ligand for the farnesoid X receptor (FXR), which is involved in many physiological and pathological processes. A series of alkylated bile acid analogues were designed, studied and patented by Roberto Pellicciari and colleagues at the University of Perugia, with 6α-ethyl-chenodeoxycholic acid emerging as the most highly potent FXR agonist. FXR-dependent processes in liver and intestine were proposed as therapeutic targets in human diseases. ...
phdthesis{74940f46-d0d9-4356-b681-6f1d36e11610, abstract = {In this thesis, the nutritional regulation and clinical significance of selenoprotein P (SeP) in human plasma of healthy and diseased subjects was investigated. For the analysis of SeP, a radioimmunoassay was developed using polyclonal antibodies. The epitope recognized by the antibodies was apparently stable after storage of plasma in the frozen state for years. In the studies included, the coefficient of variation for the concentration of SeP was 3.8-7.7% within assays, and 5.4-7.5% between assays.,br/,,br, ,br/,,br, The levels of SeP among healthy adults from different parts of Europe varied significantly. When the highest concentration of SeP encountered in samples from Maldegem (Belgium) was set to 100%, the mean concentration for the lowest region was 69% for Epirus (Greece). These differences would largely be expected to reflect differences in selenium intake. In two similar trials, healthy Finnish males were daily receiving oral ...
Selenoprotein P analysis in human plasma - A discrepancy between HPLC fractionation of human plasma with heparin-affinity chromatography and SDS-PAGE with immunoblot analysis
Ultra-Pure Selenomethionine is the most bioavailable form of selenium. Selenomethionine has been shown to be essential for proper thyroid function in particular conversion of T4 to T3 the active form of the thyroid hormone. It has also been found to support the immune system. Research studies have found that maintainin
China Disperse Dye: Disperse Blue (183) , Disperse Blue Se-2r, Find details about China Disperse Blue 183, Disperse Blue Se-2r from Disperse Dye: Disperse Blue (183) , Disperse Blue Se-2r - Qingdao Ever-Bright Industrial Co., Ltd.
Gold-containing preparations which improve the adhesiveness, guarantee an esthetic appearance, and should make possible a saving in gold consumption are needed for the production of intermediate layers for the facings of fired on alloys in the dental art with ceramic compositions. This is accomplished with preparation that contain 50 to 94% gold powder having a particle size |30μ, 5-40% binder made of organic solvent and resin components are 1-20% of a metal powder whose particle size is greater than of the gold powder used and whose melting temperature is above that of gold.
Selenoprotein V (SELV), 0.4 ml. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site.
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Selenium is an essential nutrient. The Recommended Dietary Allowance (RDA) for selenium is considered to be the amount required to optimize plasma selenoproteins. There are two selenoproteins present in the plasma: selenoprotein P (Se-P) and glutathione peroxidase 3 (GPX-3). Although the amount of selenium required to optimize GPX-3 has been determined, the amount required to optimize Se-P in the plasma remains unknown. We aim to determine this amount by supplementing selenium deficient subjects with varying amounts of selenium as selenomethionine.. The study will take place in Mianning County, China, where selenium status is low. Approximately 150 people will be screened for eligibility to participate in this study. 98 subjects will be enrolled. Background information obtained from each participant will be: age, height, weight and smoking status.. Subjects will be randomized to a selenium supplement group. The selenium supplement will contain either 0, 20, 40, 60, 80, 100, or 120 µg of ...
Poor absorption of bile acid is the cause of chronic diarrhea in a large proportion of cancer patients, new research shows. The study of 506 patients with diarrhea and a variety of cancer types found that 43 percent had bile acid malabsorption (BAM), suggesting an opportunity to substantially improve quality of life in patients with this complication. The study provides the basis for a more focused approach to diarrhea in cancer patients, said Frank Phillips, MD, a trainee gastroenterologist at the Royal Marsden Hospital, in London, England, who presented the study at Digestive Disease Week 2014. ...
ML-210,the most potent compound in the nitroisoxazole series, is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively ...
[126 Pages Report] Check for Discount on Global and China High Purity Zinc Selenide Market Insights, Forecast to 2026 report by QYResearch Group. High Purity Zinc Selenide market is segmented by region (country),...
SEQ00000394_2.0 # Sequence # SECIS binding protein 2 (SBP2) # Sloth (Choloepus hoffmanni) Full length # Reverse NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN ...
Learn more about Selenium at Oak Hill Hospital Supplement Forms/Alternate Names Selenite Selenomethionine Selenized Yeast Selenium Dioxide Uses Principal....
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Yeast-free selenium from pure selenomethionine. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.
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Selenium Role in Healthy Skin and Hair Study shows selenium and selenoproteins play beneficial role in the health of hair and keratinocytes. The trace mineral Selenium is essential to the body and good health, with a small amount of it going a long way. Selenium is incorporated into proteins to make selenoproteins, which are important …. Share on Facebook. ...
Selenomethionine, by Neurobiologix, has antioxidant properties that help the body prevent cellular damage. One of its most valuable roles is as a cofactor of an important antioxidant enzyme in the body called glutathione peroxidase.
This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. (NCBI ...
Learn more about Selenium at Portsmouth Regional Hospital Supplement Forms/Alternate Names Selenite Selenomethionine Selenized Yeast Selenium Dioxide Uses Principal...
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Please allow 5 days processing for this item. An Oligo Remedy by Mediral 1 Fluid oz. Liquid You may need Selenium Oligo Homeopathic if you suf