TY - CHAP. T1 - Biophysics of selectin-mediated cell adhesion. AU - Cheung, L. S.L.. AU - Raman, P. S.. AU - Wirtz, D.. AU - Konstantopoulos, K.. PY - 2012/12/1. Y1 - 2012/12/1. N2 - Selectins (L-, P- and E-selectin) are Ca2+-dependent transmembrane glycoproteins presented on the surface of circulating leukocytes, activated platelets, and endothelial cells at sites of inflammation/infection. Selectins bind primarily to sialofucosylated glycoproteins and glycolipids (E-selectin only) on apposing cells, and mediate loose adhesive interactions pertinent to inflammatory disorders and blood-borne metastasis. The fast association and dissociation rates of selectin-ligand bonds coupled to their remarkably high tensile strengths enable them to initiate cell tethering and rolling interactions under physiological flow conditions. This chapter reviews mathematical models and experimental methodologies to highlight the biophysics of selectin-mediated cell adhesion. It summarizes experimental observations on ...

Thursday, May 22, 2003 (Dr. Cheng Zhu, advisor) Quantitative Study of Selectin-Mediated Adhesion Under Flow Abstract During inflammation and thrombosis, leukocytes and platelets primarily tether to and roll on vascular surfaces through selectin molecules under shear flow. Selectins are a family of type I membrane glycoproteins and consist of three types: P-, E-, and L-selectin. The association and dissociation of two or more selectin-mediated bonds produce the rolling motion of the leukocytes. Association and dissociation rates characterize how fast the attachment or detachment of the bonds occurs, respectively. These kinetic properties of the selectins are affected by their mechanical environment as well. Although much has been uncovered about the properties of selectins, the complete story of the selectin-mediated adhesion process is yet to be told. The goal of this research is to use flow chamber techniques to study selectin-mediated cell adhesion to gain a more quantitative understanding ...

TY - JOUR. T1 - Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. AU - Avila, P. C.. AU - Boushey, H. A.. AU - Wong, H.. AU - Grundland, H.. AU - Liu, J.. AU - Fahy, J. V.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background: Selectins participate in the initial phase of leucocyte migration from circulation to inflamed tissues and may play a role in inflammatory cellular influx into airways in asthma. In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%. Objective: To determine whether a single dose of TBC1269 inhibits early (EAR) and late (LAR) asthmatic responses, and whether it inhibits sputum leucocyte influx after inhalation allergen challenge in atopic asthmatic subjects treated with bronchodilators only. Methods: Twenty-one asthmatic subjects (mean ± SD, age = 32.5 ± 6.7 years, 8 males, FEV1 percent predicted = 84 ± 15%) with known late asthmatic response based on a screening inhalation allergen ...

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Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) are sialylated and fucosylated carbohydrate molecules which, in most cases, decorate mucin-like glycoprotein membrane receptors. Studies using blocking monoclonal antibodies have shown that inhibition of selectin function can ameliorate a range of inflammatory processes, offering the possibility that antagonists of selectin function may be useful in the treatment of inflammatory lung diseases such as asthma.. ...

The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers. All three known members of the selectin family (L-, E-, and P-selectin) share a similar cassette structure: an N-terminal, calcium-dependent lectin domain, an epidermal growth factor (EGF)-like domain, a variable number of consensus repeat units (2, 6, and 9 for L-, E-, and P-selectin, respectively), a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). The transmembrane and cytoplasmic parts are not conserved across the selectins being responsible for their targeting to different compartments. Though they share common elements, their tissue distribution and binding kinetics are ...

Figure 2.79 - Selectin bound to a sugar Wikipedia. Selectins (Figure 2.79) are cell adhesion glycoproteins that bind to sugar molecules. As such, they are a type of lectin - proteins that bind sugar polymers (see HERE also). All selectins have an N-terminal calcium-dependent lectin domain, a single transmembrane domain, and an intracellular cytoplasmic tail.. There are three different types of selectins, 1) E-selectin (endothelial); 2) L (lymphocytic; and 3) P (platelets and endothelial cells. Selectins function in lymphocyte homing (adhesion of blood lymphocytes to cells in lymphoid organs), in inflammation processes, and in cancer metastasis. Near the site of inflammation, P-selectin on the surface of blood capillary cells interacts with glycoproteins on leukocyte cell surfaces. This has the effect of slowing the movement of the leukocyte. At the target site of inflammation, E- selectin on the endothelial cells of the blood vessel and L-selectin on the surface of the leukocyte bind to their ...

Selectins are adhesion molecules that resist large tensile forces applied by hydrodynamic forces to leukocytes binding to vessel walls. In crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orientation between their tandem lectin and EGF domains. I examine how tensile force exerted on a selectin-ligand complex in vivo could favor the more extended, high-affinity conformation. Allostery is transmitted from the EGF-lectin domain interface to the ligand-binding interface on the lectin domain, 30 A away. Trp-1 of the lectin domain and the long axis of the EGF domain form an L-shaped prybar that is welded together by hydrogen bonds to the Trp-1 alpha-amino group. Pivoting of the prybar induced by force demolishes an interface between the Trp-1 side chain and the lectin domain at a switch1 region. These changes are transmitted by rigid body movement of the switch2 region to rearrangements in the switch3 region at the ligand binding site. Another switch region ...

Free Online Library: The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.(Research Article, Report) by Mediators of Inflammation; Biological sciences B cells Analysis Disease susceptibility Physiological aspects Pregnant women T cells Health aspects Women Womens health

The finding that TRAP is especially pronounced in T cells is remarkable, because T cells do not express TLR75 and do not respond directly to R-848 in the cell culture (data not shown). Thus, although the general effect of PBL depletion by R-848 is similar to the action of a well-known immunosuppressant, FTY720, the mechanisms involved must be different. FTY720 has been shown recently to inhibit the emigration of lymphocytes from lymphoid tissue by down-regulating a sphingosine-1-phosphate receptor, which lymphocytes need to leave lymphatic tissues.45 Instead, our data suggest that the endothelium is important for mediating TRAP. This assumption is based on the following observations: (1) In the presence of selectin blockade adoptively transferred leukocytes remained attached to the major vascularized organs (also nonlymphatic) in mice receiving R-848 (Figure 3), while in PBS-treated mice the leukocytes showed general homing to the spleen, which is known to be independent of selectin function.46 ...

By solving the solution conformation of a potent selectin antagonist, it was shown that the acid pharmacophore is pre-organized prior to binding by intramolecular interactions of hydrophobic residues. This antagonist showed stronger binding affinities over mimics with a flexible acid moiety. Based on these results, a series of selectin antagonists was designed and synthesized, where the acid pharmacophore is incorporated in a ring system and therefore, locked in the bioactive conformation (Chapter 3.2.1/Manuscript). The synthesis of two additional cyclic selectin antagonist series was not successful. Possible reasons are discussed in chapter 3.2.1.2 ...

This binding between an integrin and its partner ligand (expressed on the blood vessel wall) is strong enough to fully arrest the immune cells, which can then squeeze through the gaps in between the cells that make up the walls of the blood vessel.. The final piece of the puzzle that you need to understand is what causes the activation of the integrin. Chemical signals called chemokines are produced by inflammed tissues, and these chemokines interact with receptors on the immune cells, telling them to extend their integrins in order to dock onto the vessel wall.. To recap: cells lining the blood vessel express selectins that bind sugars on immune cells, slowing them down and letting them roll along the vessel wall. Chemokines then signal to the immune cells that its time to activate their integrins, which can then grab tightly to the vessel wall, allowing the cell to stop and migrate across and into the tissue.. What I havent mentioned yet is that there are many different kinds of selectins, ...

Inflammation is defined as the normal response of living tissue to injury or infection. It is important to emphasize two components of this definition. First, that inflammation is a normal response...

The research activity of our laboratory is focused on the study of the molecular mechanisms that regulate malignant leukocyte interactions with their microenvironment. We identified selectin ligands expressed by acute myeloid and lymphoblastic leukemia cells and characterized the role of PSGL-1, CD43 and CD44 in supporting myeloblast and lymphoblast interactions with selectins.. Presently, our aims are: ...

Selectins represent a new family of adhesion molecules, expressed by leukocytes and endothelial cells, that are involved in the regulation of leukocyte traffic.

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Selectins, are known to be increased in the serum of patients with pre-eclampsia, indicating that these molecules are possible markers of endothelial cell injury. In this study, we investigated P,Eand Lselectin levels in normal pregnancy,pre-eclampsia, and missed abortus. Plasma P and L selectins levels were significantly higher in normal pregnancy and pre-eclampsia than healthy controls; but plasma concentrations of E selectins were not different between these groups. Plasma P selectin was significantly higher in pre-eclampsia than normal pregnancy. Plasma concentrations of all selectins were significantly higher in missed abortus than healthy control. L selectin levels were higher in pre-eclampsia and missed abortus than normal pregnancy. We found the levels of selectins were increased in pre-eclampsia and missed abortus. Although selectins were suspected to play a role in the pathogenesis of pre-eclampsia, in conjunction with previous studies, we thought that elevated selectin levels are a non

My laboratory is interested in transcriptional control of leukocyte traffic during inflammation and immunity. Our focus is on glycosyltransferase genes which encode enzymes which contribute to the biosynthesis of glycan ligands for selectins. Selectins are carbohydrate-binding adhesion molecules which control leukocyte recruitment during inflammation as well as homeostatic functions such as lymphocyte recirculation through secondary lymphoid organs and leukocyte traffic to bone marrow. At lea...[Read full text]My laboratory is interested in transcriptional control of leukocyte traffic during inflammation and immunity. Our focus is on glycosyltransferase genes which encode enzymes which contribute to the biosynthesis of glycan ligands for selectins. Selectins are carbohydrate-binding adhesion molecules which control leukocyte recruitment during inflammation as well as homeostatic functions such as lymphocyte recirculation through secondary lymphoid organs and leukocyte traffic to bone marrow. At ...

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. P-selectin glycoprotein ligand-1 (PSGL-1) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best ...

Severe trauma acts as a trigger for the complex cascade of postinjury events leading to the re-lease of different mediators and the development of generalized inflammation. Selectins are a family of adhesion proteins that are responsible for the adherence of polymorphonuclear neu-trophils to the endothelium. This interaction plays an important role in the development of severe complications after multiple trauma. The aim of the present study is to follow the sequential altera-tions in circulating selectins level after severe injury and to evaluate the clinical significance of these mediators in monitoring prognosis and outcome. Thirty four severely traumatized patients were entered into the study. Serum sE-selectin, plasma sP-selectin and sL-selectin concentrations were me-asured and an APACHE II score was calculated on admission to the intensive care unit and during the subsequent 5 days. The patients were divided into survivors and nonsurvivors. Initial soluble P- and E-se-lectin ...

Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting. Tumour-associated endothelium offers an additional mechanism for enhanced viral uptake into tumours which is accessible for systemic gene delivery. Building on expertise in using polymer stealthed viruses for targeting in vivo, adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] to ablate normal infection pathways. Direct linkage of a monoclonal antibody against E-selectin (MHES) demonstrated E-selectin-specific transduction of tumour necrosis factor-α (TNF-α)-activated endothelial cells. A two-component targeting system using protein G was developed, to provide optimal antibody orientation. We report an enhancement in transduction of TNF-α-activated endothelium in vitro and ex vivo in a human umbilical vein cord model using the MHES antibody. Similarly a virus retargeted using a chimeric P-selectin Glycoprotein

The three selectins (P-selectin, L-selectin, and E-selectin) have related and sometimes overlapping functions in cell adhesion and mediate some of the best characterized glycan-dependent cell adhesion events. Of the ligands for these three C-type lectins, the target ligand of P-selectin, P-selectin glycoprotein ligand 1 (PSGL-1), is the best understood. Thus, P-selectin is used here to represent all three selectins. ...

The King Lab works at the interface between Cellular Engineering, Drug Delivery, and Nanotechnology. They employ tools and concepts from engineering to understand biomedically important processes that occur in the bloodstream, including cancer metastasis, inflammation, and thrombosis. They have found that tumor cells in the circulation can mimic the physical mechanisms used by white blood cells to traffic through the body and adhere to the blood vessel wall, and have explored strategies to interrupt this metastasis process by targeting specific adhesion receptors. The selectin adhesion receptors important in leukocyte, stem cell, and CTC trafficking have unique biophysics that make them ideal for targeted drug delivery. The King Lab has pioneered the use of selectin proteins to deliver apoptosis death signals to tumor cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes. The King lab is currently testing these novel cancer ...

TY - JOUR. T1 - The micro-mechanics of single molecules studied with atomic force microscopy. AU - Fisher, Thomas E.. AU - Marszalek, Piotr E.. AU - Oberhauser, Andres. AU - Carrion-Vazquez, Mariano. AU - Fernandez, Julio M.. PY - 1999/10/1. Y1 - 1999/10/1. N2 - The atomic force microscope (AFM) in its force-measuring mode is capable of effecting displacements on an angstrom scale (10 Å = 1 nm) and measuring forces of a few piconewtons. Recent experiments have applied AFM techniques to study the mechanical properties of single biological polymers. These properties contribute to the function of many proteins exposed to mechanical strain, including components of the extracellular matrix (ECM). The force-bearing proteins of the ECM typically contain multiple tandem repeats of independently folded domains, a common feature of proteins with structural and mechanical roles. Polysaccharide moieties of adhesion glycoproteins such as the selectins are also subject to strain. Force-induced extension of ...

Bonds between adhesion molecules are often mechanically stressed. A striking example is the tensile force applied to selectin-ligand bonds, which mediate the tethering and rolling of flowing leukocytes on vascular surfaces(1-3). It has been suggested ...

Cell-cell adhesion is a well-regulated mechanism, cells dont just stick together randomly, this interaction is mediated by specific molecules on the cell surfaces. The responsible proteins for that are the Cell Adhesion Molecules (CAMs) like integrins, cadherins and selectins. Which of these CAMs are present on the surface of a cell determines if those cells will bind to each other or not. Cells can change their ability to adhere to each other or the extracellular matrix by expressing or not expressing different kinds of these molecules. You can find a lot more information about this topic in the cell-cell adhesion chapter of Molecular Biology of the Cell, available on the NCBI homepage.. ...

We demonstrate an additional step and a positive feedback loop in leukocyte accumulation on inflamed endothelium. Leukocytes in shear flow bind to adherent leukocytes through L-selectin/ligand interactions and subsequently bind downstream and roll on inflamed endothelium, purified E-selectin, P-selectin, L-selectin, VCAM-1, or peripheral node addressin. Thus adherent leukocytes nucleate formation of strings of rolling cells and synergistically enhance leukocyte accumulation. Neutrophils, monocytes, and activated T cell lines, but not peripheral blood T lymphocytes, tether to each other through L-selectin. L-selectin is not involved in direct binding to either E- or P-selectin and is not a major counterreceptor of endothelial selectins. Leukocyte-leukocyte tethers are more tolerant to high shear than direct tethers to endothelial selectins and, like other L-selectin-mediated interactions, require a shear threshold. Synergism between leukocyte-leukocyte and leukocyte-endothelial interactions ...

The role of selectins in mediating eosinophil recruitment in vivo was assessed in a model of lipopolysaccharide (LPS)-induced mouse pleurisy. LPS administration

Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection[2]. E-selectin levels correlate with disease activity in psoriasis patients[3]. L-selectin levels correlate with disease activity in type I diabetes[4]. ...

Built-in profiles are tuned to every construct and material to ensure uniform heating and cooling without the residual stresses launched in laser-based mostly methods. Although ligand formation is the premise for a lot of the transport of heavy metals all through the body, some metals could compete with ionized species equivalent to calcium and zinc to maneuver through membrane channels in the free ionic type.. Metals react simply with different parts, their atoms giving up electrons to type optimistic ions and compounds often called salts. For materials for our legacy desktop 3D printers, go to our shop web site to order on-line. Name just a few scrap yards in your area forward of time for an inventory of scrap metals they accept for recycling or jump to the recycling locator to find a location now.. Making the funding in a metal Additive Manufacturing machine is, for many, the first step on a journey to actually understanding how the expertise can rework a enterprise. The other group, referred ...

In contrast to sessile cell types, lymphocytes migrate through the vasculature to become diffusely distributed in tissues or organized in lymphoid structures. A complex array of adhesion molecules including selectins, integrins and their counter-receptors mediate lymphocyte homing and migration into …

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monoclonal antibody EP-5C7: produced by immunizing mice with murine pre-B cell lines, transfected with human E & P selectin; neutralizes both selectins; promising for treatment of inflammatory diseases caused by unregulated expression of E- & P-selectin

This chapter focuses on the generation and maintenance of the acquired immune response against bacterial pathogens and the pathological effects that may occur if this response is left uncontrolled or actively disregulated. The chapter outlines the general mechanisms of acquired immunity, and then, using specific examples, discusses how various bacterial pathogens induce and modulate this response. Lymphocytes communicate with high endothelial venules via receptor-ligand interactions, which induce lymphocyte transmigration. These adhesion molecules include selectins, integrins, and members of the immunoglobulin (Ig) superfamily. For infections with intracellular bacteria in particular, CD4 T cells dominate both the induction and effector phases of the immune response. Peptides that are presented by major histocompatibility (MHC) class I molecules are generated from endogenous proteins or proteins that are secreted into the cytoplasm. In light of this, CD8 T-cell responses are central to the immune

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rolls during the following 0.53 seconds. The white arrow marks the initial site of interaction. Supplemental data of a video depicting the BM intravital microscopy model can be downloaded at http://www.jci.org/cgi/content/full/110/4/559/DC1. Bars in ...

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cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00059 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00008 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-3 (M10.005) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-1 (M10.001) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by ADAM17 peptidase (M12.217) cleavage. KLDK-SFSM.. ...

Results The mean soluble selectin levels are shown in Table 1. sE- and sL-selectin levels were significantly higher in patients with active RA compared to inactive patients (respectively p , 0.05 and p , 0.05). Although sP-selectin level was higher in active RA patients than those in inactive patients, the difference did not reach statistically significant (p = 0.06). Significant correlations were found between sL-selectin and CRP (p , 0.05), and white blood cell count (p , 0.01) and between sP-selectin and CRP (p , 0.01), and erythrocyte sedimentation rate (p , 0.01). There were no correlations between selectin levels and Larsen score. sE-selectin level was increased in RA patients with advanced functional impairment (56.0 ± 39.8 in stage III-IV vs. 32.7 ± 13.6 ng/ml in stage I-II, p , 0.05). The presence of pulmonary involvement in patients with RA was not correlated with soluble selectin levels. sE-selectin levels was significantly higher in SSc patients with pulmonary fibrosis compared to ...

Listing the same citation under 2 or more entries, known as double-posting, is helpful when readers might be expected to look equally frequently in more than one place.benign prostatic hyperplasia (BPH) (BPH) BPH (benign prostatic hyperplasia) prostatic hyperplasia, benign (BPH) cTnC, 246 cTnC, 246 TnC, 345 [cTnC is listed in both the cs and in the ts.] However, for entries that will also appear in a series of related subentries under a main heading, cross-references to the principal form of entry are preferred to double-posting.Acceptable: E-selectin, 550 P-selectin, 551 Selectins E-selectin, 550 P-selectin, 551 Preferred: E-selectin. See under selectins P-selectin. Less ...

Listing the same citation under 2 or more entries, known as double-posting, is helpful when readers might be expected to look equally frequently in more than one place.benign prostatic hyperplasia (BPH) (BPH) BPH (benign prostatic hyperplasia) prostatic hyperplasia, benign (BPH) cTnC, 246 cTnC, 246 TnC, 345 [cTnC is listed in both the cs and in the ts.] However, for entries that will also appear in a series of related subentries under a main heading, cross-references to the principal form of entry are preferred to double-posting.Acceptable: E-selectin, 550 P-selectin, 551 Selectins E-selectin, 550 P-selectin, 551 Preferred: E-selectin. See under selectins P-selectin. Less ...

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Alpay K, Farshchian M, Tuomela J, Sandholm J, Aittokallio K, Siljamäki E, Kallio M, Kähäri VM, Hietanen S. Inhibition of c-Abl Kinase Activity Renders Cancer Cells Highly Sensitive to Mitoxantrone. PLoS One. 2014 Aug 22;9(8):e105526.. Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J. Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest. 2014 Mar;124(3):1069-82.. Asghar MN, Emani R, Alam C, Helenius TO, Grönroos TJ, Sareila O, Din MU, Holmdahl R, Hänninen A, Toivola DM. In vivo imaging of reactive oxygen and nitrogen species in murine colitis. Inflamm Bowel Dis. 2014 Aug;20(8):1435-47. Auvinen K, Jalkanen S, Salmi M. Expression and function of endothelial selectins during human development.Immunology. 2014 Nov;143(3):406-15.. Böcking D, Wiltschka O, Niinimäki J, Shokry H, Brenner R, Lindén M, Sahlgren C. Mesoporous silica ...

Polyclonal antibody for E SELECTIN/SELE detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. E SELECTIN/SELE information: Molecular Weight: 66655 MW; Subcellular Localization: Cell membrane ; Single-pass type I me

TY - JOUR. T1 - P-selectin/ PSGL-1 Inhibitors versus enoxaparin in the resolution of venous thrombosis. T2 - A meta-analysis. AU - Ramacciotti, Eduardo. AU - Myers, Daniel D.. AU - Wrobleski, Shirley K.. AU - Deatrick, K. Barry. AU - Londy, Frank J.. AU - Rectenwald, John E.. AU - Henke, Peter K.. AU - Schaub, Robert G.. AU - Wakefield, Thomas W.. PY - 2010/4/1. Y1 - 2010/4/1. N2 - Background: P-selectin antagonism has been shown to decrease thrombogenesis and inflammation in animal models of deep venous thrombosis (DVT). Objective: To determine the effectiveness of P-selectin inhibitors versus saline and enoxaparin in venous thrombus resolution in nonhuman primate models of venous thrombosis. Methods: Studies reporting vein re-opening, inflammation expressed as Gadolinium enhancement and coagulation parameters were searched in the literature and pooled into a meta-analysis using an inverse variance with random effects. Results: Five studies were identified comparing P-selectin/ PSGL-1 ...

Inflammation and thrombosis are interrelated. For example, inflammation increases TF, platelet reactivity, fibrinogen, and leads to exposure of increased levels of phosphotidylserine, while decreasing TM and inhibiting fibrinolysis (by increasing PAI-1).4 We have used both a rat and mouse model of inferior vena cava (IVC) thrombosis in studies of the basic mechanisms of thrombogenesis and thrombus resolution. Cell adhesion molecules (CAMs) allow leukocyte transmigration, and selectins (P and E-selectin) are integrally involved in thrombosis. Selectins are the first upregulated glycoproteins on activated endothelial cells and platelets. The cell adhesion molecule P-selectin has been found upregulated in the vein wall as early as 6 h after thrombus induction, whereas E-selectin has been found upregulated at day 6 after thrombosis.5. Microparticles (MPs) are involved in the thrombotic process and the amplification of thrombosis. MPs are small (less than 1 micrometer, about the size of a bacterium), ...

Looking for online definition of P-selectins in the Medical Dictionary? P-selectins explanation free. What is P-selectins? Meaning of P-selectins medical term. What does P-selectins mean?

Objectives To examine microparticles (MPs) from patients with SLE and healthy handles (HCs) by determining the cellular origin from the MPs, quantifying attached fragments of go with element 3 (C3) and assessing the power of MPs to bind to circulating phagocytes and erythrocytes. of MPs bearing C3 fragments was higher in sufferers with SLE than in HCs (p=0.026), however the quantity of opsonising C3b/iC3b substances was lower (p=0.004). The C3b/iC3b level correlated with the focus of circulating C3 (rs=0.53, p=0.036). Erythrocytes and Phagocytes from sufferers and HCs destined autologous MPs, and granulocytes from sufferers bound 13% even more MPs than those from BMS-477118 HCs (p=0.043). The current presence of erythrocytes inhibited the MP binding to granulocytes by around 50%. Conclusions Our demo of altered structure of C3 fragments on MPs from sufferers with SLE, including reduced amounts of opsonising C3 fragments, and competitive binding of MPs to circulating phagocytes and erythrocytes ...

Varicella-Zoster disease (VZV) is a herpesvirus that becomes latent in sensory neurons after primary infection (chickenpox) and subsequently may reactivate to cause zoster. repression that is associated with latency of herpes simplex virus the prototypic alpha herpesvirus. Latency has been defined as the reversible nonproductive infection of a cell Amyloid b-peptide (25-35) (human) by a replication-competent virus (1). Several viruses have Amyloid b-peptide (25-35) (human) developed strategies to establish latency in the infected host to prevent their elimination by the host immune response. Varicella-Zoster virus (VZV) is an alpha herpesvirus that becomes latent in dorsal root ganglia (DRG) after primary infection and subsequently may reactivate to cause zoster. It is essential to understand the molecular mechanisms governing VZV latency and reactivation as approximately 15% of the human population will develop zoster (2 3 and possibly experience postherpetic neuralgia a debilitating pain ...

Dysfunction of cell adhesion occurs during cancer metastasis. Loss of cell-cell adhesion in metastatic tumour cells allows them to escape their site of origin and spread through the circulatory system.[5] One example of CAMs deregulated in cancer are cadherins, which are inactivated either by genetic mutations or by other oncogenic signalling molecules, allowing cancer cells to migrate and be more invasive.[6] Other CAMs, like selectins and integrins, can facilitate metastasis by mediating cell-cell interactions between migrating metastatic tumour cells in the circulatory system with endothelial cells of other distant tissues.[35] Due to the link between CAMs and cancer metastasis, these molecules could be potential therapeutic targets for cancer treatment. There are also other human genetic diseases caused by an inability to express specific adhesion molecules. An example is leukocyte adhesion deficiency-I (LAD-I), where expression of the β2 integrin subunit is reduced or lost.[36] This leads ...

A diverse family of cell surface and extracellular glycoproteins involved in cell-cell adhesion, cell-extracellular matrix adhesion, recognition, and activation. There are four main classes of cell adhesion molecules: integrins, selectins, cadherins, and immunoglobulin-like adhesion molecules. [National Cancer Institute Thesaurus].. ...

Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes ...

INTRODUCTION The activation of inflammatory mechanisms in obstructive sleep apnea (OSAS) as a possible explanation of the increased cardiovascular risk has been repeatedly suggested by the detection of increased levels of biomarkers such as TNF alpha, selectins, adhesion proteins, interleukins, and particularly the C-reactive protein (CRP).. AIMS AND METHODS We investigated the relationship among CRP, clinical and laboratory data and nocturnal cardiorespiratory monitoring parameters in a group of obese patients (42F, 44M mean BMI 43,9) submitted for suspected, never treated OSA, aged from 20 to 68 years (mean 44,3).. RESULTS Mild, moderate and severe OSA syndrome was diagnosed in 20, 24 and 46% of patients.. Greater values of AHI, ODI, creatinine, hemoglobin and lower HDL cholesterol levels were detected in men compared with women, with similar age and BMI.. CRP was greater in women(9.86+5.6 vs 6.66+3.6, p 0.016). Its levels were significantly associated with larger values of BMI (r 0.34, p ...

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4.43E-01 (DAFVAIVQSVK;EAILDIITSR;MTNYDVEHTIK;SLEDALSSDTSGHFR;SLHQAIEGDTSGDFLK;ILISLATGHREEGGENLDQAR;ALIEILATR;DLEADIIGDTSGHFQK;GLGTDEDTIIDIITHR;GTVRPANDFNPDADAK;MLVVLLQGTR;WGTDEAQFIYILGNR;DLIADLK;EDAQ ...