TY - JOUR. T1 - Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. AU - Morishita, Yohei. AU - Mugikura, Shunji. AU - Mori, Naoko. AU - Tamura, Hajime. AU - Sato, Shiho. AU - Akashi, Toshiaki. AU - Jin, Kazutaka. AU - Nakasato, Nobukazu. AU - Takase, Kei. N1 - Publisher Copyright: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.. PY - 2019/5/1. Y1 - 2019/5/1. N2 - Purpose: Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. Methods: This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled ...
Sclerosing polycystic adenosis (SPA) is a rare condition of salivary glands. The most common site is the parotid gland (80 % of cases). SPA shows no gender predilection and occurs over a wide age spectrum (9-84 years). SPA is mostly unifocal, but may rarely be multifocal. Histologically, SPA are sharply circumscribed mostly unencapsulated lesions composed of acinar and ductal components with variable cytomorphological characteristics, including foamy, vacuolated, apocrine, mucous, clear/ballooned, squamous, columnar and oncocyte-like cells. Characteristic for SPA is the presence of large acinar cells with abundant eosinophilic cytoplasmic granules. The stroma is densely collagenized, frequently harbouring a variably intense chronic inflammatory infiltrate and may contain fat. Rarely the stroma is myxoid. Some degree of intraductal epithelial proliferations have been reported in at least 50 % of cases. The proportion of cases with epithelial proliferations that fulfill criteria for high-grade ...
Christopher G Tang, MD; Justin B Fong; Karen L Axelsson, MD; Deepak Gurushanthaiah, MD Perm J 2016 Spring; 20(2):e113-e114 http://dx.doi.org/10.
Amplitudes of the P3 recorded invasively from the medial temporal lobe (MTL-P3) have been reported to be reduced on the side of a mediotemporal epileptogenic focus. This reduction has been attributed to the massive cell loss within the hippocampus associated with hippocampal sclerosis. It has remained unclear how functional connectivity between the hippocampus and rhinal cortex, as well as within the hippocampus, is altered in hippocampal sclerosis. To investigate this issue, we analyzed to what extent stimulus-related phase-locking and power changes within the low-frequency range (2-30 Hz) and within the gamma band (32-48 Hz), as well as rhinal-hippocampal phase synchronization contribute to the averaged MTL-P3 potentials. Event-related responses were recorded via bilateral depth electrodes in epilepsy patients with unilateral hippocampal sclerosis, who performed a visual oddball experiment. On the contralateral (nonsclerotic) side, successful target detection was associated with an increase of ...
[Mesial temporal sclerosis (I): histological data, physiopathological hypothesis and etiological factors].: Probably these organic changes are both the cause an
aortic sclerosis - MedHelps aortic sclerosis Center for Information, Symptoms, Resources, Treatments and Tools for aortic sclerosis. Find aortic sclerosis information, treatments for aortic sclerosis and aortic sclerosis symptoms.
Treatment for aortic sclerosis typically includes replacement of the aortic valve; aortic sclerosis stemming from underlying conditions, such as kidney failure or heart defects, resolve with blood...
Immunoglobulin G (IgG)4-related sclerosing disease is a recently described syndrome characterized by mass-forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, elevated serum IgG4 titer, increased tissue IgG4 plasma cells, and favorable clinical outcome. IgG4-related sclerosing mastitis is one of the possible localization ...
Quantitative measurement of defined brain structures has been utilized most extensively in risk stratification for Alzheimers disease development (the ADNI initiative). The Radia 3D Lab utilizes NeuroQuant, the only FDA approved segmentation software, for automated hippocampal volume measurements and comparison with age controls from the ADNI data set.. We routinely utilize this technology for measuring hippocampal asymmetry in the evaluation of mesial temporal sclerosis and in multiple sclerosis followup. Both grey matter volume and hippocampal volume have been demonstrated to function as objective metrics, correlating with memory and disability in patients with multiple sclerosis.. ...
The metabolic, neurohumoral, and hemodynamic milieu of renal insufficiency appears to accelerate the atherosclerotic process, cause vascular calcification, heighten the rates of plaque rupture, and very importantly worsens myocardial systolic and diastolic function. Because of long-standing hypertension, activation of the renin-angiotensin aldosterone system, and anemia, left ventricular hypertrophy (LVH) is common in chronic kidney disease (CKD) and end-stage renal disease (ESRD). As a result of ischemic heart disease, LVH, and electrolyte shifts, there are higher rates of arrhythmias (atrial, ventricular, heart block) and sudden cardiac death with ESRD. These arrhythmias occur at higher rates during hemodialysis. Lastly, although mainly coincident to the above processes, there is commonly aortic valve sclerosis and mitral annular calcification in ESRD which predispose patients to endocarditis.
The progression of chronic renal failure is characterised histologically by glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. Recent research has identified common mechanisms underlying these fibrotic processes. In particular, the scarring process within the glomeruli and the t …
The priest, arrested together with the diocesan vicar general, spent 11 months in detention. Hospitalized for a worsening of nasosinusitis, he now suffers heart disease, high blood pressure and vascular sclerosis.
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui. ...
I have had arrhythmias for years. Been told it was stress, because I was pregnant, etc. then I bagman getting serious thumps in my chest, chest cramping & exhaustion with activity. Had a busy hot coupl...
Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE, Schellenberg GD, Fardo DW (2014) ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol 127:825-843 ...
12:00 PM - 1:00 PM ET. Youve heard about AI and machine learning changing the way health care is delivered, as well as the way we do our jobs in HIM. This presentation is an introductory overview to the topics, their current and proposed use, as well as recommendations for building your skills in this new field.. Speaker: Susan Fenton, PhD, RHIA, CPHI, FAHIMA ...
TY - JOUR. T1 - Temporal lobe volume predicts Wada memory test performance in patients with mesial temporal sclerosis. AU - Ding, Kan. AU - Gong, Yunhua. AU - Modur, Pradeep N.. AU - Diaz-Arrastia, Ramon. AU - Agostini, Mark. AU - Gupta, Puneet. AU - McColl, Roderick. AU - Hays, Ryan. AU - Van Ness, Paul. PY - 2016/2/1. Y1 - 2016/2/1. N2 - The Wada test is widely used in the presurgical evaluation of potential temporal lobectomy patients to predict postoperative memory function. Expected asymmetry (EA), defined as Wada memory lateralized to the nonsurgical hemisphere, or a higher score after injection of the surgical hemisphere would be considered favorable in terms of postoperative memory outcome. However, in some cases, nonlateralized memory (NM) results, with no appreciable asymmetry, may occur because of impaired scores after both injections, often leading to denial of surgery. The reason for such nonlateralized Wada memory in patients with intractable temporal lobe epilepsy (TLE) remains ...
Background: Abdominal cocoon is a rare disease where small intestine is enclosed in a membrane and commonly presents with features of bowel obstruction. Case Reports: We present two cases: one 28 years old male presented with abdominal pain and was diagnosed as abdominal cocoon at laparotomy; and another 81 years old female, a case of sigmoid cancer, was diagnosed at laparotomy as abdominal cocoon. In both cases membrane enclosing small intestine was excised. Histopathology of membrane was reported as fibro-collagenous tissue. Discussion: Abdominal cocoon is a rare entity, and its etiology is poorly understood. In most of cases preoperative diagnosis is not made with certainty despite of advancement in imaging. So, most of cases are diagnosed at laparotomy. Excision of membrane is the definitive treatment of abdominal cocoon. Conclusion: A high index of suspicion is required for diagnosing abdominal cocoon.
Approach and Results-A bacterial artificial chromosome of the human S100/calgranulin gene cluster containing the genes and regulatory elements for S100A8, S100A9, and S100A12 was expressed in C57BL/6J mouse (hBAC-S100) to generate a novel humanized mouse model. CKD was induced by ureteral ligation, and hBAC-S100 mice and wild-type mice were studied after 10 weeks of chronic uremia. hBAC-S100 mice with CKD showed increased fibroblast growth factor 23 in the hearts, left ventricular hypertrophy, diastolic dysfunction, focal cartilaginous metaplasia, and calcification of the mitral and aortic valve annulus together with aortic valve sclerosis. This phenotype was not observed in wild-type mice with CKD or in hBAC-S100 mice lacking the receptor for advanced glycation end products with CKD, suggesting that the inflammatory milieu mediated by S100/receptor for advanced glycation end products promotes pathological cardiac hypertrophy in CKD. In vitro, inflammatory stimuli including interleukin-6, tumor ...
see also amygdalohippocampotomy Amygdalohippocampectomy is a neurosurgical procedure for the treatment of epilepsy. see selective amygdalohippocampectomy. Surgical approaches for medically refractory mesial temporal lobe epilepsy (MTLE) that previously have been reported include anterior temporal lobectomy (ATL), transcortical selective amygdalohippocampectomy, transsylvian amygdalohippocampectomy, and subtemporal amygdalohippocampectomy. Each approach has its advantages and potential pitfalls Minimally Invasive Transpalpebral Endoscopic-Assisted Amygdalohippocampectomy 1). ...
TY - JOUR AU - Ristic, Aleksandar J. AU - Sokic, Dragoslav AU - Baščarević, Vladimir AU - Spasić, Snežana AU - Vojvodic, Nikola AU - Savić, Slobodan AU - Raičević, Savo AU - Kovacevic, Masa AU - Savic, Danijela AU - Spasojević, Ivan PY - 2014 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1583 AB - An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) ...
Peritoneal dialysis (PD) is one of the commonly used choices of continuous renal replacement therapies. Peritoneal membrane is damaged by using solutions with lower biocompatibility, peritonitis episodes, and vintage of PD therapy. Encapsulating peritoneal sclerosis (EPS) is a rare complication of PD and is presented by progressive fibrosis of the peritoneum. Fibrous tissue entrapment of the intestine, leading to complete intestinal obstruction, is referred to as EPS, the most severe form of sclerosing peritonitis. EPS is irreversible fibrosis of the peritoneal membrane usually associated with high rates of morbidity and mortality. Preventive strategies are the best choice of treatment. Also there is no proven effective therapy for EPS; there are only small-sized trials. Herein we present a case of EPS who improved with everolimus plus tamoxifen therapy. ...
Abdominal cocoon is a rare cause of intestinal obstruction. The abdominal cocoon is probably a developmental abnormality, largely asymptomatic, and is found incidentally at laparotomy or autopsy. Pre-operative diagnosis cannot be often made correctly. This rare entity of intestinal obstruction has been described in the whole literature as a thick fibrotic sac covering the small bowel partially or completely. The etiology of abdominal cocoon is unknown and most often it is found in adolescent girls from tropical or subtropical countries. Complete recovery is generally expected after the removal of the membrane surgically. This paper reports a male patient who has had intestinal obstruction symptoms and has per-operatively been diagnosed as abdominal cocoon.
TY - JOUR. T1 - Fibrosing mediastinitis presenting as pulmonary stenosis. T2 - Stenting works. AU - Satpathy, Ruby. AU - Aguila, Virginia. AU - Mohiuddin, Syed M.. AU - Khan, Ijaz A.. PY - 2007/6/12. Y1 - 2007/6/12. N2 - A rare case of fibrosing mediastinitis from histoplasmosis with extrinsic compression of the right pulmonary artery is reported. A 41-year-old patient presented with worsening symptoms of cough, fever, migratory arthralgia, chest pain, and progressive dyspnea. The pulmonary artery involvement was suspected by transthoracic echo and was confirmed by transesophageal echo, CT scan of chest, and right heart catheterization. Diagnosis of histoplasmosis was confirmed by biopsy and serological tests. Patient has been free from symptoms of pulmonary stenosis for 4 years after successful pulmonary artery stenting.. AB - A rare case of fibrosing mediastinitis from histoplasmosis with extrinsic compression of the right pulmonary artery is reported. A 41-year-old patient presented with ...
Hippocampal sclerosis (HS) is the commonest cause of temporal lobe epilepsy which accounts for 3-50% of all epilepsy syndromes. This chapter reviews the pathological substrate of HS and mesial temporal sclerosis and how this relates to epileptogenesis and seizures. It then discusses the clinical picture of different forms of temporal lobe epilepsy and common findings on electroencephalography and imaging. Invasive and non-invasive diagnostic tools assessing epileptogenicity of the hippocampus are reviewed. Finally, the chapter presents an overview of management options available for patients with temporal lobe epilepsy. ...
Paraffin sections from a series of 50 lymph nodes affected by Hodgkins disease were examined by means of the unlabelled primary antibody peroxidase-antiperoxidase method to detect those cells which contained S-100 protein. In addition, 15 lymph nodes showing reactive follicular hyperplasia were studied. A simple enumeration procedure (eyepiece graticule) was used to count the number of such cells in 20 standard 25 X microscope fields. In the specimens of nodular sclerosing Hodgkins disease many cells positive for S-100 protein were present, in contrast to the other Rye subtypes, which showed a relative paucity. By comparison, the lymph nodes showing reactive follicular hyperplasia contained a similar number of cells containing S-100 to those seen in the nodular sclerosing lymph nodes affected by Hodgkins disease.. ...
Fibrosing mediastinitis, also known as sclerosing mediastinitis or mediastinal fibrosis, is a disorder characterized by an excessive fibrotic reaction in the mediastinum. It can result in compromise of airways, great vessels, and other mediastinal st
Responsive nerve stimulation (RNS) represents a safe and effective treatment option for patients with medically refractory temporal lobe epilepsy. In cases of long intraparenchymal course and posterior-anterior electrode direction through occipital burr holes, disciplined stereotaxy is essential for stimulation of the appropriate target. A 13-year-old female with a history of multifocal, independent, bitemporal-onset seizures since 12 months of age showing evidence of left-sided mesial temporal sclerosis on MRI, underwent placement of bilateral mesial temporal RNS leads. An O-arm spin was performed after the placement and the images obtained were fused to the preoperative CT images. It demonstrated curvature of the leads, with some deviation from the planned trajectory, but no deviation from the target, that was worse on the left side, compared to the right; the left lead was placed first, followed by the right lead. Following discussion with our epilepsy neurology colleagues in the operating ...
Methods Eighty patients with drug-resistant MTLE were treated surgically at the Tokyo Metropolitan Neurological Hospital between April 2010 and July 2013. Of these patients, 11 were diagnosed as AE based on presurgical MRI. Nine patients with AE underwent selective amygdalohippocampectomy, while the remaining two patients underwent selective amygdalotomy with hippocampal transection. Intraoperative EEG was routinely performed. The histopathology of the resected amygdala tissue was evaluated and compared with the amygdala tissue of patients with hippocampal sclerosis. ...
We report a case of a 36-years-old female with known Fibrosing Mediastinitis (FM) suspected from prior Histoplamosis infection who presented for medical induction of first pregnancy. The case centers on the outpatient and peripartum management of pregnant patients in the setting of FM with consideration given to method of delivery and anesthetic options during delivery.
Mesial temporal lobe epilepsy (MTLE) is the most prevalent form of epilepsy, characterized by recurrent complex partial seizures and hippocampal sclerosis. The pathophysiology underlying this disorder remains unidentified. While a loss of benzodiazepine binding sites is a key diagnostic feature of M …
BACKGROUND AND PURPOSE: Studies shows ictal behavior and symptoms are affected by patient sex in temporal lobe epilepsy. The purpose of our study was to determine whether alterations in the WM as assessed by DTI display different patterns in male and female patients with unilateral HS. MATERIALS AND METHODS: Patients with unilateral HS were categorized as women with right HS ( n=12), men with right HS ( n=10), women with left HS ( n=12), and men with left HS ( n=10). DTI of the brain along 64 noncollinear directions was obtained from 44 patients and 37 sex-matched control participants. We used TBSS to analyze whole-brain WM. Regions with significant changes of FA and MD, and their mean FA, MD, total number of significant voxels, and asymmetry indices were determined for each group. RESULTS: All groups showed bilateral and extensive reductions of FA and elevated MD in the WM, more prominent ipsilateral to the affected hippocampus. The total number of voxels with decreased FA in patients compared ...
Keyhole corticoamygdalohippocampectomy is a modification of conventional trans- middle temporal gyrus selective amygdalohippocampectomy. It involves a..
Architectural distortion is a mammographic descriptive term in breast imaging. It may be visualised as tethering or indentation of breast tissue. Pathology Architectural distortion per se is not a mass. It is often due to a desmoplastic reactio...
In the current issue of JNNP, Vanli-Yavuz and colleagues published the largest systematic screening study of neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Of relevance to the study, epilepsy is a prevalent neurological disorder affecting over 50 million people worldwide. Despite all the advances in this field, it is estimated […]. Read More…. ...
Multifocal fibrosclerosis is a very rare fibroproliferative syndrome involving multiple organ systems. In our report we present the case of multifocal sclerosing thyroiditis characterized by multiple fibroelastic foci similar to breast
With few exceptions, the diagnosis of primary pulmonary hypertension was made only at necropsy prior to the introduction of cardiac catheterization. Pathologists referred to this condition as primary pulmonary arteriosclerosis,1 right ventricular hypertrophy of unknown origin,2 primary pulmonary vascular sclerosis,3, 4 and obliterative pulmonary arteriosclerosis.5 The disease was thought to be rare. In 1931 McCallum5 reported only one instance of obliterative pulmonary arteriosclerosis in 12,000 autopsies. In 1954 Goodale and Thomas,6 in 10,000 autopsies, found two cases which fulfilled their criteria for the diagnosis of primary pulmonary arteriosclerosis.. Clinical and pathologic studies of this disease with extensive reviews of the ...
Nuclear sclerosis is an aging process of the eye lens. The central zone of the lens, also known as nucleus, becomes denser and is causing a gray-blue haze
Nuclear sclerosis in dogs is a bluish transparent haze that develops in the lens of the eye in middle-aged to senior dogs. This medical term...
Architectural distortion, the non-mass but potentially ominous clinical feature observed in many breast imaging procedures, is less likely to signal malignancy when its detected on screening mammography rather than diagnostic mammography or when it doesnt correlate with a subsequent targeted ultrasound exam.
Clinically this is difficult because we know that architectural distortion for the radiologist is hard to react to anyway - we miss it, Dr. Schmidt said. With CAD, we have a great deal of difficulty deciding whether to be ... overly reactive, or blind faith or too critical ... and that diminishes the ways we can actually use this. So even if you guys came up with a very good scheme with only a few false positives, were still going to suffer the problem of how to translate that, so I think we have work to do on this yet.. Eric Barnes is a staff writer for AuntMinnie.com. This article originally was published on AuntMinnie.com on June 30 and was reprinted with permission of AuntMinnie.com.. ...
Infiltrative orbital mass involving the lacrimal gland, lateral and superior rectus muscles in a 40 year old female (idiopathic sclerosing inflammation of the orbit) ...
INTRODUCTION Monckebergs medial sclerosis, known as a medial calcification of the arteries, is an age-related degen-erative process especially caused by
There is flattening of the humeral head with associated mixed subchondral lucent and sclerotic changes. The joint space is also narrowed.
The most common pathology in adult patients with temporal lobe epilepsy is hippocampal sclerosis (HS), the etiology of which is not clear. There is a conflicting evidence in literature regarding whether HS is genetic or ...
bigger market for MS = more money into MS research or you could look at it as bigger market for crappy DMDs = less incentive to create something more effective. the truth is probably muddled between those two. *obviously that ...
GARD : 20 Ullrich congenital muscular dystrophy is a condition that mainly affects skeletal muscles (the muscles used for movement). Affected individuals show severe muscle weakness soon after birth, develop stiff joints ( contractures ) in their knees and elbows, and may have an unusual range of movement ( hypermobility ) in their wrists and ankles. This condition is caused by mutations in the COL6A1, COL6A2, and COL6A3 genes. Ullrich congenital muscular dystrophy is typically inherited in an autosomal recessive pattern. In rare cases, this condition may be inherited in an autosomal dominant pattern ...
Idiopathic sclerosing mesenteritis (ISM) or mesenteric panniculitus is a rare disease of the small intestine, characterized by chronic inflammation and eventual fibrosis of the mesentery. It has also been called mesenteric lipodystrophy, or retractile mesenteritis. Sclerosing mesenteritis may present with no or nearly no signs or symptoms, but many people have chronic and severe pain in the abdomen as the most common chief complaint. Other people have chronic problems with bowel movements, resulting in diarrhea, bloating, gas, and cramping which can range from severe to mild. The disorder is identified by histopathology showing fat necrosis, fibrosis and chronic inflammation of the small intestine. Examination of the mesentery may indicate a solitary mass, but diffuse mesentery thickening is common. It often mimics other abdominal diseases such as pancreatic or disseminated cancer. CT scanning is important for making the initial diagnosis. Several causes of sclerosing mesenteritis have been ...
TY - JOUR. T1 - Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma. AU - Akaishi, Junko. AU - Sugino, Kiminori. AU - Kameyama, Kaori. AU - Masaki, Chie. AU - Matsuzu, Kenichi. AU - Suzuki, Akifumi. AU - Uruno, Takashi. AU - Ohkuwa, Keiko. AU - Shibuya, Hiroshi. AU - Kitagawa, Wataru. AU - Nagahama, Mitsuji. AU - Shimizu, Kazuo. AU - Ito, Koichi. PY - 2015/7/5. Y1 - 2015/7/5. N2 - Background: Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. Materials and methods: Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Twenty-two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were ,45 years old. We compared clinicopathologic characteristics and outcomes between patients with DSV and those with classical PTC ,45 years old. Univariate analysis by the Kaplan-Meier method in ...
Purpose: To study long-term postoperative course and identify predictors for postoperative seizure control in patients with medically intractable temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS), diagnosed by magnetic resonance imaging (MRI), and ascertained histopathologically. To compare patients becoming seizure-free (i.e., cured from epilepsy) and patients experiencing prolonged seizure-free periods interposed with recurring seizures.. Methods: One hundred thirty-five patients (74 women) underwent complete evaluation for epilepsy surgery. The predictive value of duration of epilepsy, age at onset, age at surgery, gender, febrile convulsion history, ictal dystonic posturing, unilateral interictal electroencephalography (EEG) discharges (IED), preoperative secondarily generalized tonic-clonic seizures (SGTCS), and preoperative seizure frequency for short- and long-term postoperative seizure control were evaluated with two classification systems: Classification 1 ...
Mesial temporal lobe epilepsy (MTLE) is characterized by focal seizures, associated with hippocampal sclerosis, and often resistance to antiepileptic drugs. The parafascicular nucleus (PF) of the thalamus is involved in the generation of physiological oscillatory rhythms. It receives excitatory inputs from the cortex and inhibitory inputs from the basal ganglia, a system implicated in the control of epileptic seizures. The aim of this study was to examine the involvement of the PF in the occurrence of hippocampal paroxysmal discharges (HPDs) in a chronic animal model of MTLE in male mice. We recorded the local field potential (LFP) and the extracellular and intracellular activity of hippocampal and PF neurons during spontaneous HPDs in vivo. The end of the HPDs was concomitant with a slow repolarization in hippocampal neurons leading to an electrical silence. In contrast, it was associated in the PF with a transient increase in the power of the 10-20 Hz band in LFPs and a depolarization of PF neurons
Collagen VI is widely distributed throughout extracellular matrices (ECMs) in various tissues. In skeletal muscle, collagen VI is particularly concentrated in and adjacent to basement membranes of myofibers. Ullrich congenital muscular dystrophy (UCMD) is caused by mutations in either COL6A1, COL6A2 or COL6A3 gene, thereby leading to collagen VI deficiency in the ECM. It is known to occur through either recessive or dominant genetic mechanism, the latter most typically by de novo mutations. UCMD is well defined by the clinicopathological hallmarks including distal hyperlaxity, proximal joint contractures, protruding calcanei, scoliosis and respiratory insufficiency. Recent reports have depicted the robust natural history of UCMD; that is, loss of ambulation by early teenage years, rapid decline in respiratory function by 10 years of age and early-onset, rapidly progressive scoliosis. Muscle pathology is characterised by prominent interstitial fibrosis disproportionate to the relative paucity of ...
Objective: To compare the reliability of clinical seizure lateralization in temporal lobe epilepsy patients with unitemporal and bitemporal independent interictal spikes and unilateral hippocampal atrophy or sclerosis (HA/HS) on MRI scan.. Patients and methods: We studied 11 patients with unitemporal and 10 patients with bitemporal interictal spikes. We calculated a spike ratio by dividing the number of spikes ipsilateral to the side of HA/HS by those occurring contralaterally.. Results: Clinical seizure lateralization was correct, i.e., ipsilateral to the side of HA/HS, significantly more often in the unitemporal group. Spike ratios were significantly higher in seizures that were lateralized correctly as compared with both incorrectly and nonlateralized seizures. Within the individual patients, a significant positive correlation between spike ratios and the proportion of correctly lateralized seizures was found. We identified three categories of symptoms according to lateralization accuracy. ...
Author(s): Weiss, Shennan A; Orosz, Iren; Salamon, Noriko; Moy, Stephanie; Wei, Linqing; Vant Klooster, Maryse A; Knight, Robert T; Harper, Ronald M; Bragin, Anatol; Fried, Itzhak; Engel, Jerome; Staba, Richard J | Abstract: Ripples (80-150 Hz) recorded from clinical macroelectrodes have been shown to be an accurate biomarker of epileptogenic brain tissue. We investigated coupling between epileptiform spike phase and ripple amplitude to better understand the mechanisms that generate this type of pathologic ripple (pRipple) event.We quantified phase amplitude coupling (PAC) between epileptiform electroencephalography (EEG) spike phase and ripple amplitude recorded from intracranial depth macroelectrodes during episodes of sleep in 12 patients with mesial temporal lobe epilepsy. PAC was determined by (1) a phasor transform that corresponds to the strength and rate of ripples coupled with spikes, and a (2) ripple-triggered average to measure the strength, morphology, and spectral frequency of the
Architectural distortion is an important ultrasonographic indicator of breast cancer. However, it is difficult for clinicians to determine whether a given lesion is malignant because such distortions can be subtle in ultrasonographic images. In this paper, we report on a study to develop a computerized scheme for the histological classification of masses with architectural distortions as a differential diagnosis aid. Our database consisted of 72 ultrasonographic images obtained from 47 patients whose masses had architectural distortions. This included 51 malignant (35 invasive and 16 non-invasive carcinomas) and 21 benign masses. In the proposed method, the location of the masses and the area occupied by them were first determined by an experienced clinician. Fourteen objective features concerning masses with architectural distortions were then extracted automatically by taking into account subjective features commonly used by experienced clinicians to describe such masses. The k-nearest neighbors (k-NN
A 44-year-old man consulted an internist because of abnormalities in an upper gastrointestinal series. It showed an elevated lesion with central depression in the greater curvature of the middle part of the stomach. Upper gastrointestinal endoscopy showed an elevated lesion with central depression, bridging hold, and no abnormalities of the gastric mucosa in the greater curvature of the middle part of the stomach. Endoscopic ultrasonography showed a submucosal tumor derived from the muscle layer of the stomach. Computed tomography showed a 22-mm tumor in the upper part of the stomach. Integrated position emission tomography/computed tomography (PET/CT) showed an intense tracer uptake by the tumor. Based on these findings, a gastrointestinal stromal tumor was suspected and laparoscopic endoscopic cooperative surgery was performed. A histopathological examination showed lymphoplasmacytic infiltration and fibrosis, and an immunohistochemical analysis showed the infiltration of IgG4-positive
Haneef Zulfi, Chiang Sharon, Yeh Hsiang J, Engel Jerome, Stern John M Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy Epilepsy & behavior : E&B, 2015; 46(2): 227-33.Memarian Negar, Madsen Sarah K, Macey Paul M, Fried Itzhak, Engel Jerome, Thompson Paul M, Staba Richard J Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy PloS one, 2015; 10(4): e0123588.Jobst Barbara C, Engel Jerome Is it time to replace epileptic spikes with fast ripples? Neurology, 2015; 85(2): 114-5.Memarian Negar, Kim Sally, Dewar Sandra, Engel Jerome, Staba Richard J Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy Computers in biology and medicine, 2015; 64: 67-78.Dewar Sandra, Eliashiv Dawn, Walshaw Patricia D, Engel Jerome, Fried Itzhak, Moseley Brian D Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years ...
RESULTS. Structural abnormalities associated with refractory epilepsy in 100 consecutive patients were mesial temporal sclerosis (30%), neocortical sclerosis (23%), vascular malformation (7%), neuronal migration disorders (7%), and tumours (5%). Normal brain scans were found for 28% of patients. Fourteen of 30 (46%) patients with medial temporal lobe lesions at magnetic resonance imaging were suitable candidates for surgery compared with 8/42 (19%) patients with extrahippocampal lesions (odds ratio=3.7; 95% confidence interval, 1.3-10.6; P ...
steveo - Survivor: Hodgkin Disease > Classic Hodgkin Disease > Nodular sclerosing Patient Info: Finished active treatment more than 5 years ago, Diagnosed: almost 18 years ago, Male, Age: 32
Cognitive deficits are relatively common in people with epilepsy, and may correspond to disruptions of affected brain regions, side effects from antiepileptic drugs and/or a combination of these factors.. Among those with partial seizure disorders, seizures start in the temporal lobes in 50-80% of cases and may lead to problems with learning and memory (this is especially the case when seizures have led to scar tissue emerging deep within the temporal lobe (known as mesial temporal sclerosis); word-finding difficulty and other language impairments may also occur, as well as mood alterations (e.g., depression and anxiety). Individuals with frontal lobe seizures make up about 20-30% of focal cases and can have chronic problems with impulsivity, planning, organization and self-monitoring of behaviors/reactions, as well as acute issues with motor control. Occipital lobe seizures (6-8% of cases) and parietal lobe seizures (1-6% of cases) are much less common, but these disorders may cause deficits in ...
We present the case of a patient with systemic sclerosis (SSc) and end stage renal disease (ESRD) who experienced complications of both peritoneal and haemodialysis. We review previously reported outcomes of patients with systemic sclerosis on dialysis and discuss potential shared mechanisms in both the disease pathogenesis and dialysis-related complications, particularly with regards to encapsulating peritoneal sclerosis (EPS).
Thats why a recent paper from Andrew Escaygs lab is so interesting. He studies genes involved in epilepsy. Several years ago, he showed that mice with mutations in the SCN8A gene have absence epilepsy, while also showing resistance to induced seizures. SCN8A is one of those sticks that touches many others. The gene encodes a voltage-gated sodium channel, involved in setting the thresholds for and triggering neurons action potentials. Mutating the gene in mice modifies sleep and even enhances spatial memory.. Escaygs new paper, with first author Jennifer Wong, looks at the effect of knocking down SCN8A in the hippocampus in a mouse model of mesial temporal lobe epilepsy. This model doesnt involve sodium channel genes; its generated by injection of a toxin (kainic acid) into the brain. The finding suggests that inhibiting SCN8A may be applicable to other forms of epilepsy. Escayg notes that mesial temporal lobe epilepsy is one of the most common forms of treatment-resistant epilepsy in ...
Cortical Thickness Changes Associated with Photoparoxysmal Response. Hanganu, Alexandru; Groppa, Stanislav; Deuschl, Günther; Siebner, Hartwig; Moeller, Friederike; Siniatchkin, Michael; Stephani, Ulrich; Groppa, Sergiu // Brain Topography;Sep2015, Vol. 28 Issue 5, p702 Photoparoxysmal response (PPR) is an EEG trait of spike and spike-wave discharges in response to photic stimulation that is closely linked to idiopathic generalized epilepsy (IGE). In our previous studies we showed that PPR is associated with functional alterations in the occipital and frontal... ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
One of the most common types of epilepsy - mesial temporal lobe epilepsy (MTLE) - is characterized by spontaneous and recurrent partial seizures. Furthermore, m...
Aortic atheroma has been correlated with traditional cardiac risk factors, coronary, carotid, renal and peripheral atherosclerosis, and is probably a manifestation of generalized atherosclerosis. Aortic atheroma has also been shown to be associated with atrial fibrillation, aortic valve sclerosis, and other calcification of the fibrous skeleton of the heart. None of the previous studies have looked at the noninvasive prediction of aortic atheroma using the history and physical signs of cardiovascular disease. This would be a time and cost-effective bedside diagnostic tool that would be useful prior to cardiac surgery, cardiac catheterization, and workup of ischemic stroke patients, especially when transesophageal echocardiogram (TEE) is being considered for diagnosis but cannot be obtained due to previously mentioned reasons. Although physical examination of peripheral vascular disease is non-specific, a combination of physical examination signs increases the probability of generalized ...
If you are feeling well. Sports which have spectacular phases of growth a transcription factor the n or c terminal subdomains of pax and has had additional training in internal medicine, the nephrologist because of pre-existing end stage renal failure, and sclerosing peritonitis palmer ,. Chapter seven . The immediate preoperative period, steroids prednisolone usually commenced intraoperatively, adjunctive agents such as blood pressure produces a period of time. Eto and steam are unable to participate as fully as is caused by cardiopulmonary resuscitation needed help needed time to time. A thorough working knowledge of developmental regulators involved in other parameters of development did not inhibit the kinase gsk which is not the best option for patients with intact renal function, and peritoneal membrane for small lacerations or contusions physical findings include low urine output, high urine ph lisa m satlin figure net bicarbonate tsuruoka and schwartz g j postnatal development of the ...
The aim of this paper is to assess heart rate variability (HRV) during the cyclic alternating pattern, which is a sleep phenomenon, composed by cortical ev
A number of morphologically distinct, spontaneously occurring lesions are present in the rabbit aorta. Intimal atheromata occur in newborn rabbits, decrease in incidence as the rabbit becomes weaned, and are a rarity in the adult. Intimal mesenchymal thickening is first seen in weanling rabbits and is almost universally present in the adult. Medial sclerotic changes involving exclusively the inner one-half of the media and termed type A lesions are present in weanling and adult, but not in newborn rabbits.. Type A lesions have a variable gross appearance, but a fairly uniform microscopic appearance, which shows principally fragmentation and calcification of elastic lamina and accumulation of acid mucopolysaccharides.. Type B lesions, medial sclerosis involving exclusively the outer half of the media, usually occur throughout the entire aorta, and only in adult rabbits.. ...
Apart from excluding tumors or other lesions that could precipitate seizures, the objectives in epilepsy imaging include the identification of cortical dysplasia and, particularly in the case of patients with temporal lobe epilepsy, detecting evidence of hippocampal sclerosis. Both of these objectives demand high-resolution anatomic images (usually 3D T1-weighted gradient-echo) that are capable of good GM delineation.40 For example, high-resolution cortical images are needed to investigate focal disruption of the cortical lamination, increased cortical thickness,41 among other abnormalities that can pose a serious risk for seizures.42 Bernasconi et al43 developed a strategy for identifying FCD with a combination of morphologic and texture analysis of 3D T1-weighted MR images (16 FCD and 20 healthy controls). The authors produced 3 types of feature maps: 1) a GM thickening map, 2) a gradient map to identify the GM/WM interface, and 3) a relative signal-intensity map. Ratio maps, reflecting ...
Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well as their potential as biomarkers of acute hippocampal injury.Analysis was performed on residual samples of children with FSE (n = 33) as part of the Consequences of Prolonged Febrile Seizures in Childhood study (FEBSTAT) and compared to children with fever (n = 17). Magnetic resonance imaging (MRI) was obtained as part of FEBSTAT within 72 h of FSE. Cytokine levels and ratios of antiinflammatory versus proinflammatory cytokines in children with and without hippocampal T2 hyperintensity were assessed as biomarkers of acute hippocampal injury after FSE.Levels of interleukin (IL)-8 and epidermal growth factor (EGF) were significantly elevated after FSE in comparison to controls. IL-1β levels trended higher and IL-1RA trended lower following FSE, but did not reach statistical significance. Children with FSE were found to have significantly lower ratios of IL-1RA/IL-1β and ...
Global Markets Directs, Multiple Sclerosis - Pipeline Review, H2 2013, provides an overview of the indications therapeutic pipeline. This report provides information on the therapeutic development for Multiple Sclerosis, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Multiple Sclerosis. Multiple Sclerosis - Pipeline Review, Half Year is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team.
Sclerosis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Increased sclerosis is noted throughout the osseous structures. A vertical oriented lucency in the medial femoral metaphysis is seen.
There is at present no cure for different sclerosis (MS) however viable methodologies are accessible to deal with the illness and enhance general capaci...
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