Systemic sclerosis (SSc) is a chronic autoimmune disease that causes widespread microvascular damage and excessive deposition of collagen in the skin and internal organs. Limited cutaneous systemic sclerosis is primarily cutaneous, affecting the hands, arms, and face. Diffuse cutaneous systemic sclerosis (dcSSc) is a more serious manifestation of the disease and is often rapidly progressive, not only involving the skin, but also involving internal organs including kidney, heart, and lungs.. Subjects who have signed an Institutional Review Board/Independent Ethics Committee-approved informed consent form and met all of the inclusion/exclusion criteria will be enrolled. A total of 60 subjects will be randomized into 3 groups (1:1:1) to receive orally administered belumosudil 200 mg once daily (QD; n = 20 subjects), belumosudil 200 mg twice daily (BID; n = 20 subjects), or matched placebo (n = 20 subjects) for 28 weeks. The study will be double-blinded for the first 28 weeks followed by an ...

TY - JOUR. T1 - Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis. AU - Herrick, A L. AU - Lunt, M. AU - Whidby, N. AU - Ennis, H. AU - Silman, A. AU - McHugh, Neil J. AU - Denton, C P. PY - 2010. Y1 - 2010. N2 - Objective. Randomized clinical trials in early diffuse cutaneous systemic sclerosis (dcSSc) are challenging. We used an observational approach to estimate the relative effectiveness of different current treatment approaches, capturing entry and outcome data in a standardized way. Methods. Patients with dcSSc within 3 years of the onset of skin thickening were included. Standardized entry and followup data were collected in relation to the first disease-modifying treatment at baseline and 4-6 weeks, then 3, 6, 12, 18. 24, 30, and 36 months. The 5 different protocols were (1) intravenous cyclophosphamide followed by mycophenolate mofetil (MMF); (2) antithymocyte globulin followed by MMF; (3) MMF alone; (4) no disease-modifying treatment; (5) other ...

TY - JOUR. T1 - Imatinib mesylate (Gleevec™) in the treatment of diffuse cutaneous systemic sclerosis. T2 - results of a 24-month open label, extension phase, single-centre trial. AU - Gordon, J.. AU - Udeh, U.. AU - Doobay, K.. AU - Magro, C.. AU - Wildman, H.. AU - Davids, M.. AU - Mersten, J. N.. AU - Huang, W. T.. AU - Lyman, S.. AU - Crow, M. K.. AU - Spiera, R. F.. PY - 2014/11/1. Y1 - 2014/11/1. N2 - OBJECTIVES: We aimed to assess the long-term safety and tolerability of imatinib in diffuse cutaneous systemic sclerosis (dcSSc).METHODS: In this open-label, single-arm, extension-phase clinical trial, patients continued imatinib for 24 months following 12 months of initial treatment.RESULTS: Seventeen patients were enrolled. Forty of 92 adverse events (AE) and 0/6 serious (S) AEs were possibly related to medication. The MRSS decreased from a median of 21 to 16, (p=0.002).CONCLUSIONS: This study demonstrates long-term safety and tolerability of imatinib in a substantial proportion of ...

Objective. Randomized clinical trials in early diffuse cutaneous systemic sclerosis (dcSSc) are challenging. We used an observational approach to estimate the relative effectiveness of different current treatment approaches, capturing entry and outcome data in a standardized way.. Methods. Patients with dcSSc within 3 years of the onset of skin thickening were included. Standardized entry and followup data were collected in relation to the first disease-modifying treatment at baseline and 4-6 weeks, then 3, 6, 12, 18, 24, 30, and 36 months. The 5 different protocols were (1) intravenous cyclophosphamide followed by mycophenolate mofetil (MMF); (2) antithymocyte globulin followed by MMF; (3) MMF alone; (4) no disease-modifying treatment; (5) other immunosuppressant treatment. The primary outcome measure was the modified Rodnan skin score (mRSS). Inverse probability of treatment weights were used to allow for differing patient characteristics between groups.. Results. The study included 147 ...

Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: Application of a latent linear trajectory model. Alth...

A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Diffuse cutaneous systemic sclerosis

Chondrodermatitis nodularis chronica helicis is a rare non-neoplastic inflammatory and degenerative process of the external ear, characterized by necrobiotic changes in the dermis that extend down to the perichondrium. This condition has been occasionally reported in patients with limited cutaneous systemic sclerosis but not in those with concomitant primary biliary cirrhosis; this association is known as Reynolds syndrome. We report a 70-year-old woman diagnosed with primary biliary cirrhosis at age 47 and with limited cutaneous systemic sclerosis at age 54 who developed a painful ulcerated nodule on the helical rim of the left ear shortly after the last diagnosis. Read More ...

To study the safety and tolerability of a hyperimmune goat serum product (AIMSPRO) in the treatment of systemic sclerosis (SSc) through a period of 26 weeks of study participation. The secondary objective of the study is to assess the efficacy of AIMSPRO as a therapeutic agent for SSc using inter alia the SSc-HAQ questionnaire and the modified Rodnan skin score ...

Results Dermal and circulating ILC2s were significantly elevated in patients with SSc compared with controls. Dermal, but not circulating ILC2s were activated. Stratification of the SSc population in patients with limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) demonstrated increased levels of ILC2s in both subgroups with significantly higher frequencies in dcSSc compared with lcSSc. Moreover, dermal and circulating ILC2 counts correlated closely with the modified Rodnan skin score and with the presence of pulmonary fibrosis. ...

Results Dermal and circulating ILC2s were significantly elevated in patients with SSc compared with controls. Dermal, but not circulating ILC2s were activated. Stratification of the SSc population in patients with limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) demonstrated increased levels of ILC2s in both subgroups with significantly higher frequencies in dcSSc compared with lcSSc. Moreover, dermal and circulating ILC2 counts correlated closely with the modified Rodnan skin score and with the presence of pulmonary fibrosis. ...

In systemic sclerosis (SSc), autoantibodies provide the most accurate tool to predict the disease subset and pattern of organ involvement. Scleroderma autoantibodies target nucleic acids or DNA/RNA-binding proteins, thus SSc immune complexes (ICs) can embed nucleic acids. Our working hypothesis envisaged that ICs containing scleroderma-specific autoantibodies might elicit proinflammatory and profibrotic effects in skin fibroblasts. Fibroblasts were isolated from skin biopsies obtained from healthy subjects and patients with diffuse cutaneous SSc (dcSSc). ICs were purified by polyethylene-glycol precipitation from sera of SSc patients bearing different autoantibodies. ICs from patients with systemic lupus erythematosus (SLE) and primary anti-phospholipid syndrome (PAPS) and from normal healthy subjects (NHS) were used as controls. After incubation with ICs, fibroblasts were evaluated for ICAM-1 expression, interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, matrix metalloproteinase (MMP)

Ive been diagnosed with this recently, Im looking for anyone here in the BLF group with the same diagnosis, or any of the connective tissue disease subsets, or the lung disease subsets that all seem...

CREST Syndrome (Limited Scleroderma) Systemic scleroderma, or systemic sclerosis, is the term for the disease that is characterized by diffuse thickening of the

Peytrignet, Sébastien; Denton, Christopher P; Lunt, Mark; Hesselstrand, Roger; Mouthon, Luc; Silman, Alan; Pan, Xiaoyan; Brown, Edith; Czirják, László; Distler, Jörg H W; Distler, Oliver; Fligelstone, Kim; Gregory, William J; Ochiel, Rachel; Vonk, Madelon; Ancuta, Codrina; Ong, Voon H; Farge, Dominique; Hudson, Marie; Matucci-Cerinic, Marco; Balbir-Gurman, Alexandra; Midtvedt, Øyvind; Jordan, Alison C; Stevens, Wendy; Moinzadeh, Pia; Hall, Frances C; Agard, Christian; Anderson, Marina E; Diot, Elisabeth; Madhok, Rajan; et al (2018). Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. Rheumatology, 57(2):370-381.. Herrick, Ariane L; Pan, Xiaoyan; Peytrignet, Sébastien; Lunt, Mark; Hesselstrand, Roger; Mouthon, Luc; Silman, Alan; Brown, Edith; Czirják, László; Distler, Jörg H W; Distler, Oliver; Fligelstone, Kim; Gregory, William J; Ochiel, Rachel; Vonk, Madelon; Ancuţa, Codrina; Ong, Voon H; Farge, ...

Abstract #2884:A Phase 2 Study of Safety and Efficacy of Anabasum (JBT-101), a Cannabinoid Receptor Type 2 Agonist in Diffuse Cutaneous Systemic Sclerosis. About Anabasum Anabasum is a synthetic oral endocannabinoid-mimetic drug that preferentially binds to the CB2 receptor expressed on activated immune cells and fibroblasts. CB2 activation triggers endogenous pathways that resolve inflammation and halt fibrosis. Preclinical and human clinical studies have shown anabasum to have a favorable safety, tolerability and pharmacokinetic profile. It has also demonstrated promising potency in preclinical models of inflammation and fibrosis. Anabasum is designed to trigger the production of Specialized Pro-resolving Lipid Mediators that activate an endogenous cascade responsible for the resolution of inflammation and fibrosis, while reducing production of multiple inflammatory mediators. Anabasum also is designed to have a direct effect on fibroblasts to halt tissue scarring. In effect, anabasum is ...

You can find three classes of RNA polymerase enzyme (RNAPs I, II and III). elevated occurrence of renal participation (29.0%, cf. remainder, 11.3%; < 0.05; RR 2.6), with 40% of anti-RNAP I/II/III sufferers having renal disease. In the meantime, the current presence of anti-centromere antibodies (ACA) was connected with limited cutaneous SSc (lc-SSc) (100.0%; cf. […] ...

To the Editor:. We appreciate the experience that Wendling and colleagues have shared1. Relapsing polychondritis (RP) is a difficult condition to manage and its rarity limits our ability to study the disease and to optimize treatment strategies. Numerous reviews and case reports have cited varying success with a number of treatment strategies, but predicting which patients will respond to which treatment has been challenging. The heterogeneity of responses suggests that RP is composed of disease subsets that have distinctive pathophysiologies and natural histories. The same heterogeneity of response holds true for the use of tocilizumab (TCZ), as demonstrated by the therapeutic failure in Dr. Wendlings patient.. That patients experience highlights some important features of TCZ and RP. The normalization of the CRP suggests that interleukin 6 receptor (IL-6R) inhibition with TCZ was successful, but the persistence of symptoms raises the possibility that an alternative inflammatory pathway ...

Can you tell me whether having my hob ferret castrated will affect his working ability? No, in fact I, and many others, have experienced the exact opposite with castrated hobs. The male ferret is castrated when he is fully in season, normally around February or March. Technically, he is then no longer a hob, but a hobble. Using a hobble improves working ability, especially in the latter part of the season, as the animal s mind does not wander from its task as its body is not awash with hormones. Neutered ferrets don t flirt with each other, square up for a skirmish or try to mate with a jill when they should be bolting rabbits.However, my vet advises that, as a precaution, after the operation a hob should be kept away from any in-season jill for a month or so ...

Table 1: Improvement of Mouth Functional Disability in Systemic Sclerosis Patients over One Year in a Trial of Fat Transplantation versus Adipose-Derived Stromal Cells

Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...

Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...

Systemic sclerosis is also known as scleroderma, SSc, diffuse scleroderma, dSSc, limited scleroderma, lSSc, and CREST Syndrome. It can affect the skin, blood vessels, and internal organs.

Figure 3: Skin biopsy from the face showing dermal shrinkage.. Discussion. Progressive systemic sclerosis is an autoimmune disease of unknown etiology with an estimated annual incidence of 19 new cases per million adults per year.6 It is characterized by three major processes: disease specific autoantibodies, organ fibrosis, and small vessel vasculopathy. There is a female preponderance towards the 30-50 years age group.7 Patients can be classified into two principal subsets defined largely by the pattern of skin involvement, as well as clinical and laboratory manifestations. Diffuse cutaneous SSc is associated with progressive skin induration, starting in the fingers and ascending from the distal to proximal extremities, the face, and the trunk. These patients are at risk of early pulmonary fibrosis and acute renal involvement. Patients with limited cutaneous SSc (lcSSc) generally have long-standing Raynauds phenomenon before other manifestations of SSc appear. Skin involvement in lcSSc is ...

I thought it might be helpful to share with others how after I went gluten free 1 1/2 years ago, my stomach symptoms worsened. I felt full so quickly, would get painful attacks that would lead to vomiting, and I couldnt handle foods with much fat nor fibrous foods. 1 year ago I was diagnosed with gastroparesis. 10 months ago I was diagnosed with Hashimotos, as well as having a positive blood test for Limited Scleroderma. Over the last 10 months the scleroderma doctor has decided that I had a false positive for it. In talking with my new GI specialist, he told me that Hashimotos can cause gastroparesis. He also said that they are finding that celiac can affect the stomach. So in my case, the culprit to my gastroparesis could be either or both. I have a personal theory as well. I think I tested positive for scleroderma because I believe I was developing it. Ive read that untreated celiac can lead to scleroderma. I had most all of the symptoms for scleroderma except skin involvement. After ...

Results: A total of 576 patients were treated (288 in each group). Most (75.2%) of the patients were female, 51.9% had diffuse cutaneous SSc, and 48.4% were taking mycophenolate at baseline. Mean ± standard deviation age was 54.0 ± 12.2 years and 21.4% of patients were aged ≥65 years. Nintedanib had a consistent effect on reducing the rate of FVC decline across pre-specified subgroups defined by baseline characteristics (p>0.05 for all treatment-by-time-by-subgroup interactions). For example, the adjusted difference (95% confidence interval) between nintedanib and placebo in rate of decline in FVC was 34.6 (-9.3, 78.4) mL/year in female patients and 58.6 (-18.0, 135.1) mL/year in male patients (p=0.59). The corresponding age-related data were: 44.4 (1.4, 87.4) mL/year in patients aged < 65 years and 28.1 (-54.2, 110.4) in those aged ≥65 years (p=0.73). In patients with diffuse cutaneous SSc, the difference between nintedanib and placebo was 56.6 (3.2, 110.0) mL/year, compared with 25.3 ...

Background/Purpose: Macrophages are the primary inflammatory cell type present in the systemic sclerosis (SSc) skin. Circulating monocytes can give rise to profibrotic inflammatory cells such as alternatively activated macrophages in the fibrotic end-organ such as skin and lung. Despite their importance, there are no previous studies examining the clinical correlates of peripheral blood monocyte count in SSc. The primary objective of the present study was to examine the association of monocyte count with clinical variables and survival in the prospective Genetics Versus Environment In Scleroderma Outcome Study (GENISOS) cohort.. Methods: Monocyte count was prospectively obtained at enrollment in 429 patients. All patients had disease duration less than 5 years (from the first non-Raynauds phenomenon symptom) and fulfilled the 2013 ACR/EULAR criteria. Modified Rodnan Skin Score (mRSS) and forced vital capacity % predicted (FVC%) were also obtained prospectively. SSc related autoantibodies were ...

OBJECTIVE: To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3 enhancer complex regulatory region (IgH3EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS: A total of 116 patients with SSc were classified as diffuse (dSSc) or limited (lSSc), and as carriers of antitopoisomerase I (anti-Scl70) or anticentromere (ACA) antibodies. Allele and genotype frequencies were assessed in the population as a whole and in the two major subsets, dSSc and lSSc. The concentration of peripheral blood immunoglobulin levels was also determined and analysed according to the genotypes. RESULTS: The analysis of genotypes for the four alleles of the HS1,2A enhancer showed an increased frequency of allele *2 in the SSc cohort highly significant versus controls (57% vs. 40%, p,0.0001). Considering the autoantibody pattern, we found that the frequency of the 2/2 genotype was increased in ACA+ patients ...

Myelodysplastic syndrome (MDS) with deletion 5q (del(5q)) is a distinct clinical and pathological disease subset that is exquisitely sensitive to lenalidomide for the treatment of red blood cell transfusion-dependent anemia. Although lenalidomide has erythropoeitic promoting activity in MDS without del(5q) (non-del(5q) MDS), the frequency of response to treatment is lower and relates to biologically separate drug effects.

The ideal management of ankylosis spondylitis (AS) involves a combination of nonpharmacologic and pharmacologic treatment aiming to maximize health-related quality of life. The primary objective of this study was to demonstrate the benefits of an original multimodal exercise program combining Pilates, McKenzie and Heckscher techniques on pulmonary function in patients with AS, while secondary objectives were to demonstrate the benefits of the same program on function and disease activity. This is a randomized controlled study on ninety-six consecutive patients with AS (axial disease subset), assigned on a 1:1 rationale into two groups based on their participation in the Pilates, McKenzie and Heckscher (group I) or in the classical kinetic program (group II). The exercise program consisted of 50-min sessions performed 3 times a week for 48 weeks. Standard assessments were done at week 0 and 48 and included pain, modified Schober test (mST) and finger-floor distance (FFD), chest expansion (CE) and ...

Risk attitudes influence decisions made under uncertainty. This paper investigates the association of risk attitudes with the utilization of preventive and general healthcare services, work absence and resulting costs to explore their contribution to the heterogeneity in utilization. Data of 1823 individuals (56.5 ± 9.5 years), participating in the German KORA FF4 population-based cohort study (2013/2014) were analyzed. Individuals general and health risk attitude were measured as willingness to take risk (WTTR) on 11-point scales. Utilization of preventive and medical services and work absence was assessed and annual costs were calculated from a societal perspective. Generalized linear models with log-link function (logistic, negative-binomial and gamma regression) adjusted for age, sex, and height were used to analyze the association of WTTR with the utilizations and costs. Higher WTTR was significantly associated with lower healthcare utilization (physician visits, physical therapy, and medication

T helper 9 (Th9) cells and interleukin (IL)-9 are involved in the pathogenesis of several autoimmune diseases. The exact role of IL-9 and Th9 cells in patients with systemic sclerosis (SSc) have not yet been studied adequately. IL-9, IL-9R, transcription factor PU.1 (PU.1), IL-4, thymic stromal lymphopoietin (TSLP) and transforming growth factor (TGF)-β expression were assessed in skin and kidney biopsies of SSc patients and healthy controls (HC) by immunohistochemistry (IHC). The cellular source of IL-9 was also analysed by confocal microscopy analysis. Peripheral IL-9-producing cells were also studied by flow cytometry. The functional relevance of IL-9 increased expression in SSc was also investigated. Our results demonstrated a strong expression of IL-9, IL-9R, IL-4, TSLP and TGF-β in skin tissues of patients with both limited and diffuse SSc. IL-9 expression was observed mainly in the context of skin infiltrating mononuclear cells and keratinizing squamous epithelium. IL-9 over-expression ...

CONCLUSIONS: Nearly half of all MS patients were still employed after almost two decades of having MS. Lower age at onset, shorter disease duration, higher education, less fatigue and less disability were independently associated with current employment. These key clinical and demographic factors are important to understand the reasons to work ability in MS. The findings highlight the need for environmental adjustments at the workplace to accommodate individual s needs in order to improve working ability among MS patients. ...

The main mission of the industrial construction company ShchekinoAzot is to provide high working ability of workshops and facilities of the chemical industry. The staff is constantly running routine work, which is of big volume at pauseless working chemical production

Despite everything they do for us in a given day, it can be easy to overlook the bodys muscles. Unlike limbs or lungs that provide a very visible function, the muscles contribute to every single movement we make. Even the small ones … or ones that dont require moving at all, such as sitting or standing. In fact, we have more than 600 muscles in the body, all of which help contribute to gestures, breathing, blood flow, and more. Yet theyre still overlooked. With their incredible responsibilities, however, we need to ensure each muscle is up to top working abilities ...

Sure, there was the old sit and stay, all the usual training that dogs learn to be reasonable members of a household. But what I was learning from my dog, were the life lessons. The states of being. That dogs follow calm, assertive energy (thanks, Cesar) and how keenly theyre connected to whatever feelings their people are feeling. I drank in all the wisdom of dog behaviorists and trainers, like Patricia McConnell, Ian Dunbar, Dr. Sophia Yin, Victoria Stilwell and Cesar Millan. I plucked knowledge gems away from these doggie gurus and squirreled them away, like a hoarder surrounded by all her valuable treasures. I have a library of books about dogs - their behaviors, their communication, their working abilities, their roles in history, and their breed characteristics. I immersed myself completely in the world of dogs ...

Patient information for MEDIKINET XL 60 MG MODIFIED-RELEASE CAPSULES HARD Including dosage instructions and possible side effects.

The LSSC Program has 8 Approved Course Providers who offer stand-alone approved courses which fulfill various competency sets. Below is information on all of the Approved Courses and the Approved Course Providers. Prices for these courses can be found on the Approved Course Providers website. If you are interested in upcoming Approved Courses, please visit the Approved Course Catalog.. ...

Diagnosis and conservative treatment of neurodermatitis (costs for program #81273) ✔ University Hospital Düsseldorf ✔ Department of Dermatology ✔ BookingHealth.com

The answer to yesterdays mystery is … limited scleroderma (a.k.a. CREST syndrome)! Great job Priscilla, Kmu, American Girl Mommy, Erin, Rich S, guest, OB1, Phung, Shelly Langlois, mabel, vor120806, Kimberly Helton, CB, Kelly, ColorMaven, Jerry Skrocki, Amanda, Michelle, Tina M., Angelita, ER SEC, Mary, todd dombrowski, JP3, kim labounty, Dazed & Confused, JB, and PJ.. Ill give partial credit to those who named one component of CREST syndrome, Raynauds phenomenon: D2, Patti Ann, Carol, MG, Gracie287, GetAClue, Zach A., Tara Naz, Robert Jones, the other Naomi, Shannon Vincent, Martha, sallad, Michele Liguori, Veronica, Deborah Cote, JP, and GG.. CREST syndrome, or limited cutaneous systemic scleroderma, is an autoimmune disease that causes scarring of different tissues in the body, most notably the skin. The cause of the disease is unknown, but it is likely some combination of genetic factors and environmental triggers. First, inflammatory white blood cells infiltrate the skin and ...

This article is written to guide you on the ongoing Nigerian Army Recruitment. Do you want to apply for Nigerian Army DSSC/SSC Short Service Commission.. You need to understand that in the Nigerian Army, DSSC Stands for Direct Short Service Commission While SSC stands for Short Service Commission.. To apply successfully, you need to read the following information carefully. We promise to do our best in guiding you throughout the stages of the recruitment.. The Nigerian Army DSSC Recruitment is open to both civilians and serving military personnel. Only serving military personnel sponsored by any of the Services of the Nigerian Armed Forces to civil institutions shall be considered. Shortlist will be published on the portal. ...

BACKGROUND. Scleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease. METHODOLOGY/PRINCIPAL FINDINGS. We used immunohistochemical and mRNA in situ hybridization techniques to characterize this vasculopathy and showed with morphometry that scleroderma has true capillary rarefaction. We compared skin biopsies from 23 scleroderma patients and 24 normal controls and 7 scleroderma patients who had undergone high dose immunosuppressive therapy followed by autologous hematopoietic cell transplant. Along with the loss of capillaries there was a dramatic change in endothelial phenotype in the residual vessels. The molecules defining this phenotype are: vascular endothelial cadherin, a supposedly universal endothelial marker required for tube formation (lost in the scleroderma tissue), antiangiogenic interferon α (overexpressed in the scleroderma dermis) and ...

Authors: Ostojić, Predrag , Damjanov, Nemanja , Pavlov‐Dolijanovic, Slavica , Radunović, Goran Article Type: Research Article Abstract: Objective: To examine the difference in clinical signs of peripheral vasculopathy in patients (pts) with limited (lcSSc) and diffuse cutaneus systemic sclerosis (dcSSc). Patients and methods: Ninety one patients with systemic sclerosis (39 with lcSSc and 52 with dcSSc) have been assessed for the presence of clinical signs of vascular injury: Raynauds phenomenon, severity of capillary damage on capillaroscopy, presence or absence of finger‐tip ulcers or pitting scars, presence of telangiectasias and radiographic signs of finger‐tip osteolysis. Statistical significance of difference in clinical manifestations of peripheral vasculopathy in pts with lcSSc and dcSSc was assessed using the Mann-Whitney and X2 …‐test. Results: Duration of Raynauds phenomenon before manifestation of skin or internal organ damage, was significantly longer (z=−2.54, ...

See If You Qualify for a Local Scleroderma Research Study!. Owens, like many others, may not have been aware of the many ways systemic scleroderma can affect the bodys organs. With scleroderma affecting an estimated 300,000 Americans and African Americans being diagnosed more frequently and at an earlier age than other ethnic groups, its important to know the facts.. Myth: Scleroderma is a disease that only affects the skin.. Truth: Scleroderma is primarily characterized by thickening of the skin, but this chronic connective tissue disease can affect the blood vessels and internal organs in addition to the skin. Localized scleroderma affects certain parts of the body (usually the skin), but with systemic scleroderma the entire body can be affected - skin, kidneys, digestion, joint, teeth, lungs, heart and Raynauds Phenomenon.. Myth: Scleroderma is a genetic disease.. Truth: Scientists do not know what causes scleroderma, but researchers do not believe it is passed on through genes. According ...

A role for an autoimmune process has been proposed in the pathogenesis of PAH-SSc. Antifibrillarin antibodies (anti-U3-RNP) are frequently found in PAH-SSc patients (65), and the poorly characterized anti-endothelial cell antibodies (AECAs) correlate with digital infarcts (66). Antibodies to fibrin-bound tissue plasminogen activator in patients with limited cutaneous SSc (67) and in IPAH patients with HLA-DQ7 antigen (68) and antitopoisomerase II-α antibodies, particularly in association with HLA-B35 antigen (69), are found in PAH-SSc. Nicolls et al. (5) suggested that AECAs-which can activate ECs, induce the expression of adhesion molecules, and trigger apoptosis-play a role in PAH pathogenesis. In vitro experiments using autoantibodies from patients with connective tissue diseases (anti-U1-RNP and -dsDNA) can upregulate adhesion molecules (e.g., endothelial leukocyte adhesion molecule-1) and histocompatibility complex class II molecules on human PA ECs (70), suggesting that an inflammatory ...

As background to the report, he explained that PCI has been widely performed in patients with severe coronary disease (such as left main or triple vessel coronary artery disease) following the introduction of drug-eluting stents. However, long-term clinical outcomes of PCI relative to CABG in such patients have not yet been adequately evaluated. Although three-year results from the SYNTAX trial suggested that an excess risk of PCI relative to CABG for death, myocardial infarction or stroke was significant in the triple vessel disease subset, there were limitations in the apparent lack of statistical power to evaluate this composite endpoint.. The CREDO-Kyoto (Coronary REvascularization Demonstrating Outcome Study in Kyoto) PCI/CABG registry cohort-2 is a physician-initiated non-company sponsored 26-centre registry enrolling consecutive patients having a first coronary revascularisation between January 2005 and December 2007. The study population for the current analysis consisted of 2981 ...

Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder that results in skin fibrosis, autoantibody production and internal organ dysfunction. We previously identified four intrinsic subsets of SSc based upon skin gene expression that are found across organ systems. Gene expression regulators that underlie the SSc intrinsic subsets, or are associated with clinical covariates, have not been systematically characterized. Here we present a computational framework to calculate the activity scores of gene expression regulators and identify their associations with SSc clinical outcomes. We find regulator activity scores can reproduce the intrinsic molecular subsets with distinct sets of regulators identified for inflammatory, fibroproliferative and normal-like samples. Regulators most highly correlated with modified Rodnan skin score (MRSS) also varied by intrinsic subset. We identify a subgroup of fibroproliferative/inflammatory SSc patients with more severe pathophenotypes. We further ...

Loop recorder may detect cardiac conduction abnormalities in systemic sclerosis patients in European League Against Rheumatism (EULAR) 2016 Annual Congress | MIMS Malaysia

Michael J. Rathbone This two volume Second Edition of Modified-Release Drug Delivery Technology describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes.. Modified-Release Drug Delivery Technology provides insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value.. Modified-Release Drug Delivery Technology is available as a 2-volume set or each volume may be purchased individually.. Contents and information on Volume One ...

IJR Vol 9 No.2, July - December 2017;Correlation Between Serum Procollagen Type 1 N-Terminal Propeptide Level With Modified Rodnan Skin Score In Systemic Sclerosis Patients ...

Having a disease that nobody has heard of is a lonely business. When even the doctors cannot recognise it, or tell you what is going to happen, it is lonelier still. So Scleroderma Awareness Day was created to tell people, including the medical community, what it means to have this disabling disease. June 29 is a day to recognise the bravery of those who live with scleroderma, and to demand equal treatment and equal care for people with scleroderma across Europe.. In February 2010 the1ST SYSTEMIC SCLEROSIS WORLD CONGRESS was held in Florence, Italy, with participants from countries from all over the world. At the world congress it was agreed that June 29th would be celebrated all over the world. Scleroderma day grew from zero to world scleroderma day in 2 years, and is celebrated in countries in Europe, Australia, Canada, Brazil, India and many more countries.. ...

Thank you for visiting my personal fundraising page to support the Stepping Out to Cure Scleroderma event!. Donating through this site is simple, fast and totally secure. It is also the most efficient way to make a contribution to support me and help raise funds for scleroderma patients. To make a donation, click the Donate Now button that appears under my photo. Then, just follow the instructions.. If you would like to join me at the event, and walk and help raise funds, please click on Join My Team and follow the directions.. Please help today! I sincerely appreciate your support, and please share this with anyone who you think might want to help.. Help me bring more awareness to scleroderma so we can find a cure!. Thank you!. Love, Linda. Diagnosed with Systemic Scleroderma w/complications 2014. ...

A study found that nearly a quarter of systemic sclerosis patients with reduced gas exchange develop pulmonary hypertension within three years.

Scleroderma also known as systemic sclerosis, is a systemic autoimmune disease characterized by damage to endothelial and smooth muscle cells of the small arteries. Replacement with fibrous material results, and there is an influx of inflammatory cells. Primarily affects skin and joints but can affect the heart and lungs, and digestive tract. Some types of scleroderma are rapidly progressive and deadly. Scleroderma is often treated with immunosuppressive drugs, and there is no known cure. Some investigators are looking at using the regenerative properties of cell therapy to mitigate the impact of scleroderma. Research is ongoing to evaluate the effects of stem cells on auto-immune conditions. As recently stated in Best Practices & Research Clinical Rheumatology in a review of Scleroderma, Stem cell transplantation seems to be promising in restarting the immune system to diminish fibrosis and restore microvasculature. Read More…. ...

Adult,Aged,Atherosclerosis/blood/*complications/ultrasonography,Carotid Artery, Common/ultrasonography,Cholesterol/blood,Female,Humans,Male,Middle Aged,Patient Selection,Regression Analysis,Scleroderma, Systemic/blood/*complications/ultrasonography,Severity of Illness Index,Triglycerides/ ...

A study has found that people with diseases that cause changes in the hands and face, such as scleroderma, are more likely to avoid social situations.

In 1997 I was diagnosed with scleroderma and given a 15month prognosis. In 1998 I became a patient at the Scleroderma Unit. The cause and cure to both Scleroderma and Raynauds remain unknown. Please donate to help fund medical research where 100% of your donation will be used for research purposes only. The Royal Free Hospital has the largest centre specialising in scleroderma in the UK led by Professor Chris Denton. #SclerodermaFreeWorld #RaynaudsFreeWorld #Research. ...

In 1997 I was diagnosed with scleroderma and given a 15month prognosis. In 1998 I became a patient at the Scleroderma Unit. The cause and cure to both Scleroderma and Raynauds remain unknown. Please donate to help fund medical research where 100% of your donation will be used for research purposes only. The Royal Free Hospital has the largest centre specialising in scleroderma in the UK led by Professor Chris Denton. #SclerodermaFreeWorld #RaynaudsFreeWorld #Research. ...

Health - pups health is warranteed until they are 3 years of age. This is not a lifetime guarantee for 2 reasons. First, if there is a concern about the dogs health, it should have been checked prior to the dog reaching 3 years of age. The sooner an issue is discovered, the sooner it can begin being treated the longer the dog will enjoy a happy/healthy life. Second, I make breeding decisions based on the health of not just the parents, but their siblings, aunts, uncles, and any past offspring they have produced. The owners of the past who have health checks done on their dogs have helped shaped the decisions that were made to produce the pups of the present. It is my hope that all puppy buyers will do basic health testing on their dogs prior to 3 years of age so this information can be used to make breeding decisions for the future.. Working Ability - I make every effort to match each pup and the abilities it shows to the proper home. However, after the pup leaves my premises I have no control ...

Wayeh Kennels breeds standard-sized Alaskan Malamute puppies to be working housedogs: pet, show, and performance. At Wayeh we choose temperament, health, structure, working ability and then type - because a good Malamute must be a good dog first.

Wayeh Kennels breeds standard-sized Alaskan Malamute puppies to be working housedogs: pet, show, and performance. At Wayeh we choose temperament, health, structure, working ability and then type - because a good Malamute must be a good dog first.

Quality Puppy Is Not Expensive, It Is Simply Priceless!. Our foundation….. was started and maintained with the Old Italian Bloodlines. We are true Line Breeders. Our Pedigree is one of the Top Pedigrees available Worldwide. (Our pedigree boast many of the finest dogs in the world, in both Conformation and Working Ability.) This has given us the foundation to ensure the Sound Temperament of these Brilliant Working dogs. To consistently obtain these traits, it is imperative to know multiple generations intimately. Only through in depth knowledge and high standard in selection, is it possible to consistently produce Structure & Temperament. As a Cane Corso Breeder, our goal is to breed Cane Corso as close to the standard as possible. Correctly bred, these dogs should possess strong breed type, sound structure, and inherent desire & drive to please their master. Yet, gentle enough to be trusted, with Family & Children.. You will also find that we are a Head, Above The ...

Quality Puppy Is Not Expensive, It Is Simply Priceless!. Our foundation….. was started and maintained with the Old Italian Bloodlines. We are true Line Breeders. Our Pedigree is one of the Top Pedigrees available Worldwide. (Our pedigree boast many of the finest dogs in the world, in both Conformation and Working Ability.) This has given us the foundation to ensure the Sound Temperament of these Brilliant Working dogs. To consistently obtain these traits, it is imperative to know multiple generations intimately. Only through in depth knowledge and high standard in selection, is it possible to consistently produce Structure & Temperament. As a Cane Corso Breeder, our goal is to breed Cane Corso as close to the standard as possible. Correctly bred, these dogs should possess strong breed type, sound structure, and inherent desire & drive to please their master. Yet, gentle enough to be trusted, with Family & Children.. You will also find that we are a Head, Above The ...

Scleroderma means hard skin. It is a group of diseases that cause abnormal growth of connective tissue. Connective tissue is the material inside your body that gives your tissues their shape and helps keep them strong. In scleroderma, the tissue gets hard or thick. It can cause swelling or pain in your muscles and joints.. Symptoms of scleroderma include ...

Foreign Language Requirement. All AA degree seeking students must satisfy the foreign language requirement prior to graduation by:. Option 1) Completed and passed two years of one language in high school.. OR. Option 2) Complete and pass the second course of one foreign language sequence at the college level. OR Option 3) Take a CLEP exam and submit qualifying test scores. Any credit hours obtained at the college level may be included in the Program Electives component of the AA degree.. Civic Literacy Requirement. All first-time-in-college AA degree seeking students entering in 2018-19 and thereafter must demonstrate civic literacy through successfully passing POS 2041 or AMH 2020; scoring a 3 or higher on the AP Government & Politics test; scoring a 4 or higher on the AP U.S. History test; or scoring a 50 or higher on the CLEP American Government test.. LSSC Residency Requirement. Students must complete 25% of the AA degrees total credits (15 credit hours) at LSSC to qualify for ...

The symptoms of scleroderma (systemic sclerosis), including skin thickening, skin hardening, tight skin, itchy skin, fatigue, arthritis, and muscle pain.

Clinical updates on scleroderma and systemic sclerosis. Managing lung disease in scleroderma, autoantibody markers, scleroderma classification criteria, more.

Scleroderma is a long-lasting autoimmune disease that affects your skin, connective tissue, and internal organs. Learn more about the types, causes, risk factors, symptoms, diagnosis, treatment, and complications of scleroderma.

The diagnosis of the scleroderma syndrome is based on the finding of the clinical features of the illnesses. The diagnosis of localised types of scleroderma is based on the injuries.

What Is Scleroderma (Crest Disorder)? Scleroderma is an uncommon persistent autoimmune illness, the illness identified by the substitute of regular cells of

The Scleroderma Foundation is a qualified national nonprofit operating under 501(c)(3) status. The foundations federal tax identification number is 52-1375827. Our primary goal is to raise funds for our three-fold mission of support, education and research. The foundation has 20 active chapters and 160 support groups across the country.. ...

Hello all! Heres an informative article on Scleroderma which we came across while doing some research on the disorder. We found it informative and thought we should share it with you all. We will be; from time to time keep posting informative articles for your reading. This article has been extracted from https://www.hopkinsscleroderma.org/ on Scleroderma … Continue reading. ...

    Despite being diagnosed with Scleroderma, Karen Hamilton, RN, has remained an avid cyclist. Hamilton has riden thousands of miles across several continents to raise funds and awareness about Scleroderma. When Karen Hamilton, RN-C, CEN, CRRN, CFRN, MICN, NREMT-P, CCEMT-P, was diagnosed with Reynaud’s Disease in 1978, she didn’t think a lot about it. “At the time,

ecosanders: I already did on dis thread, u cn check ma posts, n besides its just d way some1 described above, u enter d center with frog jump wit ur load on ur head, den u check ur name wit d officials, u wil b search, den u cn go in2 ur lodge(dnt xpct of a comfortable place) u wil get ur chest number. D next day, is documentation 2 check fake credentials etc, dis may take two days or more, afta wic som ppl wil b drop, d next stage is medicals, urine, blood, sight, psychology test n physical examination(a lady checkd us last year, u hv 2 b stark Unclad) during d medicals more dan half of d candidates wil b drop, den u go for 3.5km race in 18mins, obstacles, written test and finaly u face d board ...

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hi lizbeth, welcome to the group. we actually are all kind of grouped together with different types of autoimmune diseases. I have 2 rhummies that say I have scleraderma and my internist say its lupus. I just let them fight about it. They pretty much treat them the same. Do you have it on your skin or your organs? I have a little bit on my skin nothing that noticable but my lungs are destroyed and my liver is started to show mild symptoms. Ive gone through all the test for a lung transplant but I have to be sicker before they will do it. Ive been on oxygen 24/7 for the past 6 years. I spent lots of time last year in hospital and nursing homes this year has been better except Im much more tired. Ive been running all over the state for the past 2 days to doctors and I have to go to bed. I just saw your post and wanted to let you know you are not alone. Oh also if you get a chance to look up choctaw indians and scleroderma together you might find some interesting info about how many of them ...

Definitions Of Scleroderma Disease Onset & Organ System Involvement Working Group. Goal: To develop guidelines to increase the comparability of observational studies and/or clinical trials in SSc with regard to: defining the time of onset of SSc recommending criteria for determining if an individual organ system is affected by SSc

Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading t

Learn more about Symptoms of Scleroderma at Coliseum Health System Main Page Risk Factors Symptoms Diagnosis ...

Sclerodermas main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body.. The localized type often affects only your skin. It does not harm major organs. It may get better or go away without help. But it can be severe in some people and can leave skin damage.. The systemic type affects your skin, tissues under it, blood vessels, and major organs. ...