GELABERT-GONZALEZ, M. et al. Scedosporium apiospermum brain abscess: Report of one case with literature review. Neurocirugía [online]. 2010, vol.21, n.2, pp.125-131. ISSN 1130-1473.. Scedosporium apiospermum is a fungus found in the soil and in contaminated water and commonly cause cutaneous infections and is a rare cause of central nervous system infection. Invasive infection is usually associated with immunosuppresion. The authors present a 73-year-old woman with chronic renal disease who presented with headache for 2 weeks. Computerized tomography scans revealed a ring-enhancing lesion in left temporal lobe. An urgent craniotomy was performed and the lesion was totally removed. The patient died 5 days later. Scedosporium apiospermum was isolated in the culture of the extirpated lesion. The authors review the previously reported cases of brain abscess for Scedosporium apiospermum.. Palabras clave : Brain abscess; Pseudallescheria boydii; Scedosporium apiospermum; Voriconazole. ...

Scedosporium apiospermum and S. prolificans are fungi of increasing clinical importance, particularly in persons with underlying diseases. We reviewed the records of 59 patients in Australia from whom Scedosporium spp. were isolated from June 30, 1997, through December 31, 2003. S. apiospermum was isolated predominantly from the respiratory tracts of 28 of 31 patients with underlying lung diseases and resulted in 2 infections and 1 death. The annual number of S. apiospermum isolates remained constant. S. prolificans was isolated from 28 patients only after November 1999. Eight patients with acute myeloid leukemia or hematopoietic stem cell transplants had invasive infection; 4 had fungemia and 6 died from infection. S. prolificans caused locally invasive infection in 2 immunocompetent patients and was found in the respiratory tract of 18 patients with underlying respiratory disease but did not cause fungemia or deaths in these patients. Scedosporium spp. showed distinct clinical and epidemiologic

As for Scedosporium prolificans, all combinations were indifferent but synergy was detected for 15 to 25% of isolates for some combinations. The most active combination was ravuconazole plus caspofungin, which was synergistic against 41.7% of S. prolificans isolates when MEC values were used as endpoints.. Notably, antagonism was absent for all antifungal combinations against both Scedosporium spp.. The combined activity of antifungal agents against Scedosporium has rarely been evaluated previously. A report on the combined effect in vitro of amphotericin B and azole agents (miconazole, itraconazole, and fluconazole) against S. apiospermum was published in 1995 (26). Authors used the checkerboard technique and described an average indifferent effect, but synergy was found for some isolates, particularly for the amphotericin B and miconazole combination. Antagonism was not reported.. Meletiadis et al. reported that the combination of terbinafine with miconazole, voriconazole, or itraconazole ...

Introducción. En los últimos años se observa un aumento de la prevalencia de colonización e infección por Scedosporium spp. en pacientes con fibrosis quística (FQ). En el presente estudio se registra la frecuencia de aislamiento de Scedosporium spp. en una Unidad de FQ de adultos, analizándose las características de los pacientes y los factores predisponentes.. Métodos. Se realizó un estudio observacional retrospectivo en 87 pacientes adultos con FQ en los que se valoró la presencia de cultivo positivo para Scedosporium spp. durante 5 años (enero de 2012-julio de 2017). Se recogieron las siguientes variables clínicas: edad, sexo, índice de masa corporal, genotipo, presencia de insuficiencia pancreática, colonizaciones bacterianas, función pulmonar, complicaciones, exacerbaciones y tratamiento, así como puntuación Bhalla modificada de la última tomografía computarizada axial de alta resolución. Los resultados se analizaron con el paquete estadístico IBM SPSS Statistics ...

We describe an 8-year-old girl who sustained multiple compound fractures in an accident involving agricultural equipment. She developed Scedosporium prolificans osteomyelitis of the pelvis, septic arthritis of the hip, and myositis of adjacent muscles. The infection progressed, despite extensive surgical debridement and joint washouts with 0.2% polyhexamethylene biguanide; antifungal therapy with caspofungin, terbinafine, and voriconazole; and adjunctive therapy with interferon-α. Gradual resolution was achieved after the addition of a novel agent, hexadecylphospocholine (miltefosine), and the continuation of terbinafine and voriconazole. This is the first report of the use of miltefosine as an antifungal agent in the management of severe infection with S. prolificans.. ...

S. apiospermum endophthalmitis presents with an aggressive clinical course, oftentimes requiring enucleation. Treatment is particularly challenging due to resistance to many antifungal agents. Here, we report a case of endogenous S. apiospermum endopthalmitis in a diabetic patient that responded favorably to voriconazole with full restoration of visual acuity. To our knowledge, this is the third reported case of successful treatment outcome for endogenous endophthalmitis due to this fungal species [5, 11]. Our case is unique in that voriconazole combined with early surgical intervention led to a favorable outcome.. Two cases of successful treatment outcomes for S. apiospermum endopthalmitis have previously been described. In 2007, Shankar et al. reported a case a case of endogenous endophthalmitis from an unknown source in a 61-year-old man with diabetes mellitus (DM). Anterior chamber biopsy was positive for S. apiospermum and the patient was treated with intravitreal amphotericin B and ...

Scedosporium aurantiacum ATCC ® 28206™ Designation: VH/6199/74 Application: Biomedical Research and Development Material

A 59-year-old man with a 1-month history of headache underwent consultation in an otolaryngological clinic of a general hospital. He was diagnosed with nasal septal abscess and was treated with incisional drainage and 1 month of an antibiotic drip; however, his symptoms persisted. The patient later complained of diplopia due to bilateral abducens nerve palsy, and was then referred to the department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital. The septal lesion was biopsied under general anesthesia, and S. apiospermum was detected using polymerase chain reaction. The patient was treated with an antifungal drug and surgical resection of the lesion was performed. Although the patient survived, he lost his eyesight.. CONCLUSIONS ...

Corroborating the light microscopy, SEM images showed germinated and non-germinated conidia (with a predominance of the latter morphotype) adhered to A549 (Fig. 3A-E), MRC-5 (Fig. 4A-G) and RAW (Fig. 5A, B, F) cells, after 4 h of interaction. Despite the predominance of non-germinated conidia, we opted to highlight in our SEM images the germinated conidia and hyphae due to the further consequences of these morphotypes to the host cells. Although the pattern of conidia attachment was random, it was possible to observe several nests of germinated conidia over the A549 (Fig. 3B, D) and MRC5 (Fig. 4B) cells. No fungal nest was observed in RAW macrophages. The formation of nests or clusters was also demonstrated in A. fumigatus conidia over the surface of A549 cells.(20) We hypothesised that the formation of fungal nests is one of the initial steps for building a complex and robust biofilm structure, which is preceded by the adhesion to a substrate and the germination of the conidia into hyphae.(2) ...

Results There were 4 children (all girls), median age 15 years (range 10-16), with a median FEV1% predicted of 70.5% (range 55-88%). 2 children chronically isolated L.prolificans, 2 isolated S.apiospermum. 3 also had CF related diabetes and chronic Pseudomonas aeruginosa infection. 1 child received treatment for 6 weeks. 3 children are taking long- term treatment (median 50 weeks; range 35-59). 2 children improved FEV1% predicted with treatment by 14% and 15%; one was stable. Importantly the trend graphs for lung function in these 3 children appear to stabilise post initiation of treatment. One child did not improve her lung function but also had recurrent MRSA infections and significant nutritional complications. No adverse effects from the combination were reported. Posaconazole levels were therapeutic (,1 mg/l) in all children (range 1.22-3.85 mg/l). Terbinafine levels were not measured. ...

Erstellt am18. Mai 2020 Dear valued colleagues, A new video is now available on our YouTube Channel Infectious Diseases in Motion. Our research physician Jannik Stemler presents prognostic factors and treatment strategies of invasive infections with Scedosporium spp. and Lomentospora prolificans, emerging pathogens associated with high mortality rates. Video: https://www.youtube.com/watch?v=PAe9_CKtLxQ Publication: https://bit.ly/2zxywgM We hope you enjoy watching! With best […]. Weiterlesen ...

3 Indications Requested in the NDA Treatment of invasive aspergillosis Empiric antifungal therapy of febrile neutropenic patients Treatment of: -candida esophagitis -serious candida infections -serious fungal infections due to Fusarium and Scedosporium spp. -serious fungal infections in patients refractory or intolerant to other therapy

Ventricular tachycardia can be caused by different structural abnormalities of the heart tissue, frequently related to fibrotic scars from ischemic and nonischemic origin. Cardiac tumors, particularly in pediatric patients, are also associated with clinically significant arrhythmias.1 In adults, non-Hodgkin lymphoma has been reported as a cause for ventricular arrhythmias. In this report, we describe a tumorlike cardiac fungal mycetoma caused by S apiospermum presenting as ventricular tachycardia associated with hemodynamic instability. Mycetoma is primarily a granulomatous disease of the skin and subcutaneous tissue, caused by fungi (eumycetoma) or aerobic bacteria (actinomycetoma) that occasionally involve other tissues, particularly in immunocompromised patients.2 S apiospermum endocarditis has been previously described in a patient after cardiac surgery.3 Floating atrial mycetomas caused by S apiospermum infection have been recently reported in a patient with cystic fibrosis who underwent ...

FIG. 5. One of the 2,496 most-parsimonious trees obtained from heuristic searches based on analysis produced from the combined data set. Bootstrap support values of 100% are indicated at the nodes. Type strains are indicated with boldface type. P. africana and S. prolificans were used as outgroups. Pb, P. boydii; Pe, P. ellipsoidea; Pf, P. fusoidea; Pa, P. angusta; Pm, P. minutispora; Sa, S. aurantiacum; Paf, P. africana; Sp, S. prolificans; S, source; T, teleomorph; G, Graphium anamorph; CI, consistency index; RI, retention index; HI, homoplasy index; c, clinical; e, environmental; +, presence; −, absence. ...

Leccinum aurantiacum, is a species of fungus in the genus Leccinum. It is found in forests of Europe, North America and Asia and has a large, characteristically red-capped fruiting body. In North America, it is sometimes referred to by the common name red-capped scaber stalk. There are some uncertainties regarding the taxonomic classification of this species in Europe as well as in North America. It is considered edible. The cap is orange-red and measures up to 8 in (20 cm) across. Its flesh is white, bruising at first burgundy, then grayish or purple-black. The underside of the cap has very small whitish pores that bruise olive-brown. The stem measures 4-7 in (10-18 cm) tall and to a ¾-1¼ in (2-3 cm) thick and can bruise blue-green. It is whitish, with short, rigid projections or scabers that turn to brown to black with age. Leccinum aurantiacum can be found fruiting during summer and autumn in forests throughout Europe and North America. The association between fungus and host tree is ...

uuid: ceff9c05-10d8-46b1-b214-8fa826a21f2f, type: records, etag: bfcdac2c0388d6df951ea476500b9fa81b8bc367, data: { dwc:startDayOfYear: 196, dwc:specificEpithet: aurantiacum, dwc:kingdom: Fungi, dwc:recordedBy: Smith, A. H.; Dick, E. A., dwc:order: Boletales, dcterms:references: http://mycoportal.org/portal/collections/individual/index.php?occid=1741207, dwc:scientificNameAuthorship: (Bull.) Gray, dwc:occurrenceID: 1741207, dwc:stateProvince: Michigan, dwc:eventDate: 1967-07-15, dwc:country: USA, idigbio:recordId: urn:uuid:8509c1b3-2a3d-4021-9159-e557993d873a, dwc:basisOfRecord: PreservedSpecimen, dwc:genus: Leccinum, dwc:family: Boletaceae, dwc:identifiedBy: Smith, A. H., symbiota:verbatimScientificName: Leccinum aurantiacum, dwc:rights: http://creativecommons.org/licenses/by-nc-sa/3.0/, dwc:phylum: Basidiomycota, dwc:locality: Pellston near, dwc:institutionCode: BPI, dwc:class: Agaricomycetes, ...

We report a case of lung infection by Pseudallescheria boydii, which appeared during therapeutic aplasia in a patient with acute leukaemia. The association of sudden chest pain and fever with negative blood cultures and haemoptysic expectoration first suggested a diagnosis of pulmonary aspergillosis …

Although dermatophytes occasionally infect superficial portions of the mucous membrane and skin of the eyelids, primary and secondary mycotic infections of the

1. Pistia stratiotes Linnaeus, Sp. Pl. 2: 963. 1753. 大漂 da piao Apiospermum obcordatum Klotzsch, nom. illeg. superfl.; Pistia obcordata Schleiden, nom. illeg. superfl.. Morphological characters are the same as those of the genus. Plants aquatic, floating. Roots many, pendulous in water, feathery. Leaves in rosettes, 1.3-10 × 1.5-6 cm. Spathe white, 5-12 mm. Fl. May-Nov.. Water fields, lakes, ponds. Fujian, Guangdong, Guangxi, Taiwan, Yunnan; cultivated in Anhui, Hubei, Hunan, Jiangsu, Jiangxi, Shandong, Sichuan [tropical and subtropical regions worldwide].. The plants are cultivated for animal feed and are used to treat swelling and urinary tract infections.. ...

Everything is edible once. Dont know who said that. Even those in the aurantiacum group can make some people ill (as noted already), and the fungus doesnt have to be from N America or Europe. Costa Rica for example.. In all molecular phylogenies that I have seen, yellow pored Leccinums are not true Leccinums in the sense of scabrum and aurantiacum.. Shroomydan has a couple of nice images here and he didnt cut off the stipe base this time. Good on ya!. As I have told Ian from NSW, please cut the fungus lengthwise (after taking the pics) and watch how the flesh changes. OR, post a pic of the reaction once cut. That will help.. If you want a key to genera of Boletes go here: http://www.nybg.org/bsci/res/hall boletes/. Look at the menu in the upper right. Thanks! ...

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Olorofim is currently an investigational compound under clinical development. It belongs to the orotomides, a new class of antifungal antibiotics with a new mechanism of action targeting DHODH, an enzyme essential in the pathway of de novo pyrimidine biosynthesis (18). This is a novel target, and the compound has shown potent in vitro and in vivo activity against several medically important molds, including several Aspergillus spp. (19-21, 23), the Scedosporium/Pseudallescheria species complex and Lomentospora spp. (24, 25), certain species of Fusarium, Penicillium spp., and Talaromyces marneffei (18), as well as the dimorphic human pathogens Coccidioides spp. (26).. We showed that olorofim controls the growth of seven Aspergillus spp. that have been documented from CGD patients with cases of IA, in contrast to several other commonly used antifungals. More importantly, olorofim therapy was effective in reducing mortality, pathology, GM levels, and fungal DNA loads in two different murine models ...

Psorospermun aurantiacum and Hypericum lanceolatum are plants locally used in Cameroon and other parts of Africa for the treatment of gastrointestinal and urinary tract infections, skin infections, venereal diseases, gastrointestinal disorder, infertility, epilepsy as well as microbial infections. The present study was designed in order to investigate the in vitro antimicrobial and radical scavenging activities of the extracts and isolated compounds from the leaves of these plants. The plant extract was prepared by maceration in ethyl acetate and methanol and fractionated by column chromatography. The structures of isolated compounds were elucidated by spectroscopic analyses in conjunction with literature data. The broth microdilution method was used to evaluate the in vitro antimicrobial activity against bacteria, yeasts and dermatophytes. The antioxidant potentials of the extracts and their isolated compounds were evaluated using the DPPH radical scavenging method. Five known compounds: physcion (1),

A strain of Exiguobacterium aurantiacum ATCC49676 was found to be of great potential to produce lactic acid (LA). In order to screen the metabolites that might regulate or affect the acid yield, a relative higher LA production condition was defined through full factorial experiment design. Fresh cultures harvested from the basic and the higher LA production conditions were subjected to metabolic fingerprint analysis by gas chromatography-mass spectrometry. Significance analysis indicated a distinct change of an intercellular metabolite-L-glutamic acid (Glu). When ATCC49676 was treated by Glu, LA yield declined with the increasing added Glu concentrations. Relative enzyme quantification confirmed that Glu decreased the intracellular lactate dehydrogenase content. This study proved the merit of metabolic fingerprint analysis in exploring the phenotype specific intracellular metabolite and its potential roles in improving industrial fermentation efficiencies ...

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Hépatance - Jade recherche - 120 gélules, Hepatance est composé de desmodium aescendens ( 5 pour 1 ) fortement concentré ( en deça, il na pas suffisamment deffet ), de chardon marie dosé à 80 % de sylimarine, de lécithine riche en choline...