3NGH: In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1.
Recent studies revealed that scavenger receptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis. However, the mechanisms underlying this protection remain largely unknown. In this study, using Scarb1I179N mice, a mouse model specifically deficient in hepatic SR-BI, we report that hepatic SR-BI protects against cecal ligation and puncture (CLP)-induced sepsis as shown by 75% fatality in Scarb1I179N mice, but only 21% fatality in C57BL/6J control mice. The increase in fatality in Scarb1I179N mice was associated with an exacerbated inflammatory cytokine production. Further study demonstrated that hepatic SR-BI exerts its protection against sepsis through its role in promoting LPS clearance without affecting the inflammatory response in macrophages, the glucocorticoid production in adrenal glands, the leukocyte recruitment to peritoneum or the bacterial clearance in liver. Our findings reveal hepatic SR-BI as a critical protective factor in sepsis and point out that promoting hepatic ...
Sigma-Aldrich offers abstracts and full-text articles by [Christiane Danilo, Jorge L Gutierrez-Pajares, Maria Antonietta Mainieri, Isabelle Mercier, Michael P Lisanti, Philippe G Frank].
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
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Reverse cholesterol transport (RCT), the transfer of cholesterol from peripheral tissues, including the subendothelial space of the arterial wall, to the liver for disposal, is a current model of HDL atheroprotection. The final RCT step, selective hepatic HDL-cholesteryl ester (CE) uptake, is mediated by scavenger receptor class B type I (SR-BI). The net receptor reaction of SR-BI vs. HDL is distinct from that of LDL vs. the LDL receptor. LDL holo particle uptake is succeeded by steps that breakdown apo B-100 and hydrolyze and recycle the CE. In contrast, HDL-CE uptake is selective, occurring without a concomitant net uptake of the major HDL protein, apo A-I and even though apo E and apo A-I bind equally well to SR-BI, apoA-I-containing particles mediate 2-fold more selective CE uptake. The reaction of HDL with SR-BI is similar to the activity of a streptococcal serum opacity factor (SOF) against HDL_both reactions selectively remove CE from HDL leaving remnants. In addition, SOF catalyzes the ...
Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein-cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of insulins effect on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C. This was associated with decreased expression of HDL-C clearance factors, scavenger receptor class B type I (SR-BI) and hepatic lipase, and defective selective uptake of HDL-cholesteryl ester by the liver. The phenotype could be rescued by re-expression of SR-BI. These findings demonstrate that hepatic FoxOs are required for cholesterol homeostasis and HDL-mediated reverse cholesterol transport to the liver. ...
Over the past few years, growing evidences revealed that clearance of apoptotic cells by phagocytosis can result in powerful anti-inflammatory and immunosuppressive effects. In vivo, apoptotic cells are cleared rapidly by neighboring cells, macrophages and related scavengers. Defective clearance of apoptotic cells has been linked closely to autoimmunity and persistent inflammatory disease. Several phagocytic receptors, bridging molecules produced by phagocytes and eat-me signals on apoptotic cells are coordinately involved in mediating clearance of apoptotic cells. Complement receptors (CR3, CR4), collection, CD14, CD36 (Class B scavenger receptor), class A scavenger receptor, asialoprotein receptor, Mer receptor kinase were reported to recognize apoptotic cells. The best characterized system for clearance of apoptotic cells is the recognition of phosphatidylserine (PS) on apoptotic cells by phosphatidylserine receptor (PSR). Milk fat globule- epidermal growth factor 8 (MFG-E8) is an opsonin ...
Title:CD36 as a Therapeutic Target for Endothelial Dysfunction in Stroke. VOLUME: 18 ISSUE: 25. Author(s):Sunghee Cho. Affiliation:Department of Neurology/ Neuroscience, Weill Cornell Medical College at Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, New York 10605.. Keywords:CD36, stroke, angiogenesis, inflammation, endothelial dysfunction, pro-death responses, oxidative stress, vascular dysfunction, cerebrovascular diseases, scavenger receptor.. Abstract:Stroke pathology involves multifactorial pro-death responses, including inflammation, oxidative stress, vascular dysfunction, and activation of necrotic and apoptotic pathways. The interruption of a single specific pathway in defined stroke model systems has not been sufficient to address the multifactorial nature of stroke-induced injuries in the human population. CD36 is a class B scavenger receptor that functions in regulating normal physiological and pathological functions. CD36 pathways are activated by several ...
Much evidence has pointed toward a potential contribution of adipose in mediating HDL lipidation. Adipose tissue is the major store for cholesterol within the body, and therefore represents a large pool of substrate to support HDL biogenesis. Adipose tissue expresses high levels of key cholesterol transporters ABCA1 and scavenger receptor class B type I (SR-BI; but not ABCG1),14 providing a gateway for cholesterol to efflux onto HDL. Expression of both ABCA1 and SR-BI increases during adipogenesis and adipocytes support HDL lipidation in vitro.14 Furthermore, adipocytes promote HDL lipidation in vivo, and the absence of either adipocyte ABCA1 or SR-BI impairs this process.14 ABCA1−/− adipocytes exhibited impaired efflux to apoA-I in vitro, but unaltered efflux to HDL, whereas SR-BI−/− adipocytes effluxed normally to apoA-I but failed to efflux to HDL. ABCG1−/− adipocytes exhibited normal efflux to both HDL and apo-A1, and protein levels were negligible in wild-type adipocytes.14 ...
Der Scavenger Receptor BI (SR-BI) vermittelt den selective lipid transfer von Cholesterol und Vitamin E aus HDL in die Leber. Die zelluläre Aufnahme verschiedener Lipide aus HDL über den selben Mechanismus, vermittelt durch den selben Rezeptor wirft die Frage auf, ob diese Aufnahmeprozesse einander beeinflussen. Aktuelle Forschungsergebnisse zeigen, daß die Aufnahme von neutralen Lipiden (Cholesterolester, Triacylglycerol) aus HDL in die Zelle von der Lipidzusammensetzung der Donorpartikel abhängen könnte. Wir untersuchten, ob der Vitamin-E-Gehalt von HDL die Aufnahme und den Efflux von Cholesterol in und aus HepG2-Zellen beeinflußt. Die Inkubation von HepG2-Zellen mit [3H]Cholesterol-markiertem HDL mit ansteigendem Vitamin-E-Gehalt ergab eine steigende Aufnahme von Vitamin E, während sich die Cholesterolaufnahme nicht veränderte. Der erhöhte zelluläre Gehalt an Vitamin E bewirkte eine Reduktion der PKC-Alpha- und SR-BI-Expression in Verbindung mit einem erniedrigten Cholesterolefflux ...
The overall goal of this research was to determine the effectiveness of reconstituted high-density lipoprotein (rHDL) nanoparticles as a drug delivery system against metastatic triple negative breast cancer (TNBC). TNBC patients have a less favorable prognosis than those with hormone positive breast cancers. TNBC does not respond to current endocrine treatment. Consequently, the five- year survival rate for patients with metastatic TNBC is | 30%. The studies performed here were intended to fill a void in the treatment of metastatic TNBC with the use of targeted reconstituted high-density lipoprotein (rHDL) nanoparticles, an innovative approach. The rHDL nanoparticles are small, biocompatible, non-immunogenic complexes, targeted to the high-density lipoprotein receptor (scavenger receptor class B type 1 [SR-B1]). While most malignant cells and tumors overexpress the SR-B1 receptor, its expression levels are nearly undetectable in most normal tissues. These findings present the opportunity to exploit a
Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T., Leece, L., Clayton, Z., Yuen, S., Robertson, S., Lam, M., Celermajer, D., Ng, M., Bursill, C. (2016). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes, 65(10), 3091-3103. [More Information] ...
Our laboratory focusses on understanding how enveloped viruses attach to and enter cells to initiate viral replication and immunological responses that prevent infection with a vision to develop the worlds first preventative HCV vaccine for HCV elimination. Hepatitis C Virus contains two envelope glycoproteins, E1 and E2, that function as a heterodimer to mediate attachment and virus-cell membrane fusion. The viral glycoprotein E2 is primarily responsible for receptor binding to scavenger receptor class B type 1 (SRB1) and CD81. Antibodies directed towards regions of E2 that interfere with SRB1 or CD81 binding, block virus entry and are neutralizing antibodies. Therefore, understanding the structure of E2, how it interacts with both cellular receptors and how antibodies prevent these interactions are pivotal for vaccine development. Through our studies, we have identified a leading HCV vaccine candidate (HepSeeVaxDelta3) that we are currently assessing in preclinical studies as a recombinant ...
OBJECTIVE-Scavenger receptor class B type I (SR-BI) is a cell-surface HDL receptor that is implicated in reverse cholesterol transport and protection against ...
In general, transendothelial transport of proteins occurs by paracellular and transcellular pathways. We have previously demonstrated that aortic ECs bind, internalize, and resecrete apoA-I in a competed and temperature-dependent manner.9,10 Furthermore, we demonstrated that ABCA1 but not SR-BI modulates this process.9 In the present study, we extend these findings by showing that ECs also bind, internalize, and transport mature HDL, however, by characteristics that are distinct from those of transendothelial apoA-I transport. Most importantly, SR-BI and ABCG1 but not ABCA1 are rate-limiting for HDL transport.. The presence of different pathways for the transendothelial transport of apoA-I and HDL parallels the need of at least 2 distinct molecules interacting with cells of the arterial wall and other extravascular compartments. Lipid-free apoA-I dissociates from mature HDL as a result of HDL remodeling by lipid transfer proteins and lipases.12-14 Lipid-free apoA-I is important to mediate lipid ...
CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer ce
Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes. CD36 also influences various diseases, including angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia and obesity. Genetic deficiency of this protein results in significant changes in fatty acid and oxidized lipid uptake. Comparative CD36 amino acid sequences and structures and CD36 gene locations were examined using data from several vertebrate genome projects. Vertebrate CD36 sequences shared 53-100% identity as compared with 29-32% sequence identities with other CD36-like superfamily members, SCARB1 and SCARB2. At least eight vertebrate CD36 N-glycosylation sites were conserved
Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes. CD36 also influences various diseases, including angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia and obesity. Genetic deficiency of this protein results in significant changes in fatty acid and oxidized lipid uptake. Comparative CD36 amino acid sequences and structures and CD36 gene locations were examined using data from several vertebrate genome projects. Vertebrate CD36 sequences shared 53-100% identity as compared with 29-32% sequence identities with other CD36-like superfamily members, SCARB1 and SCARB2. At least eight vertebrate CD36 N-glycosylation sites were conserved
Rabbit polyclonal Scavenger Receptor BI + BII antibody validated for WB, IP, BL, ICC/IF and tested in Human and Mouse. Referenced in 3 publications. Immunogen…
PDZK3兔多克隆抗体(ab96526)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
PDZK1兔多克隆抗体(ab64856)可与人样本反应并经WB, IHC, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). In rodents, hepatic basolateral SR-BI is important in controlling plasma lipoprotein levels and cholesterol (CH) homeostasis, with major roles in reverse CH transport (RCT) and biliary excretion. The hepatic ABCG5/G8 heterodimer is a membrane transporter present on the apical surfaces of hepatocytes, and also plays a key role in biliary CH ...
recpmid,pmid=14709891,ti=Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: mechanisms and consequences ,au=Nakanishi Y; Shiratsuchi A,so=Biol Pharm Bull 2004; 27 (1): 13-6,ab=More than half of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa during mammalian spermatogenesis. These cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells, a testicular somatic cell type possessing phagocytic activity. We have investigated the mechanism by which Sertoli cells specifically recognize and phagocytose apoptotic spermatogenic cells and the consequences of phagocytosis. We showed by in vitro as well as in vivo analyses that Sertoli cells recognize apoptotic spermatogenic cells through the binding of their surface receptor, class B scavenger receptor type I, to phosphatidylserine that is expressed on the surface of spermatogenic cells during apoptosis. The inhibition of phagocytosis in live animals resulted in a decrease ...
Biobool provide the Human Scavenger receptor cysteine-rich domain-containing protein SCART1 ELISA Kit in Competitive price and high quanlity.
Proatherogenic hyperlipidemic states not only increase the risk of cardiovascular disease in the chronic kidney disease (CKD) population but also increase the risk of worsening renal function.1,2 Given the implications that accelerating both cardiovascular disease and renal dysfunction have on morbidity and mortality in this population, investigating the mechanisms of renal glomerular and tubulointerstitial injury observed in this setting is a topic of great interest.. Recently, the apolipoprotein E (apoE) null mouse has been used as a model of hyperlipidemic renal injury and offers a valuable tool to study such mechanisms.3 On this genetic background, we and others have demonstrated that the class B scavenger receptor CD36 is a key molecule in mediating the inflammation, insulin resistance, and atherogenesis involved in proatherogenic hyperlipidemic states.4-7 CD36 is expressed on a variety of cell types including monocytes and macrophages8 and proximal tubular cells (PTCs)9 and recognizes ...
Kawecki C., et al. Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex. Cellular and Molecular Life Sciences. 1-17. 29/11/2018.. In addition to its critical role in lysosomes for catabolism of sialoglycoconjugates, NEU1 is expressed at the plasma membrane and regulates a myriad of receptors by desialylation, playing a key role in many pathophysiological processes. Here, we developed a proteomic approach dedicated to the purification and identification by LC-MS/MS of plasma membrane NEU1 interaction partners in human macrophages. Already known interaction partners were identified as well as several new candidates such as the class B scavenger receptor CD36. Interaction between NEU1 and CD36 was confirmed by complementary approaches. We showed that elastin-derived peptides (EDP) desialylate CD36 and that this effect was blocked by the V14 peptide, which blocks the interaction between bioactive ...
Shop Soluble scavenger receptor cysteine-rich domain-containing protein ELISA Kit, Recombinant Protein and Soluble scavenger receptor cysteine-rich domain-containing protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011 ...
International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).
Gene Information The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM Apr 2004]. ...
The hallmark of the human atherosclerotic plaque is the presence of lipid-laden macrophages, or foam cells. However, many macrophage subsets are found within atherosclerotic lesions and it is not well understood how monocytes differentiate into these subsets. We focused on characterizing macrophages derived in vitro from human peripheral blood monocytes treated with IL-15, IL-4 or IL-10. We show these macrophages to have differing phenotypes: CD209+CD64+, CD209+CD23+, or CD209+CD163+ for macrophages derived from IL-15, IL-4, or IL-10 respectively. To characterize the macrophage subsets ability to become foam cells we measured their uptake of fluorescently-labeled oxidized LDL (oxLDL). IL-10 derived macrophages had the greatest amount of oxLDL uptake. We then investigated the mechanism of uptake and found that fucoidan, a class-A scavenger receptor competitor, significantly inhibited uptake of oxLDL in IL-10 cells. On the other hand a blocking antibody against the class B scavenger receptor, ...
Abstract: : Purpose: To determine whether human RPE cells in culture express the following reverse cholesterol transport proteins: scavenger receptor BI (SR-BI), scavenger receptor BII (SR-BII), and ATP-binding cassette protein A1 (ABCA1); to confirm this expression in fixed human tissue sections. Methods: Primary cultures of human RPE cells were grown for at least one week at confluence prior to RNA isolation or immunofluorescent staining. RNA expression was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) of total cellular RNA using primer sets specific to human SR-BI, SR-BII or ABCA1. Immunofluorescent staining was performed using a biotinylated secondary antibody and fluoresceinated avidin. Either affinity- purified antibodies specific to SR-BI and SR-BII peptides, or commercially available antiserum to ABCA1 were used as primary antibodies, with the appropriate controls. SR-BI, SR-BII and ABCA1 proteins were visualized in RPE cells by standard and confocal ...
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008 ...
The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeding the formation of senile plaques contributes to synaptic and memory deficits in Alzheimers disease. Our previous studies have indentified scavenger receptor A (SR-A), especially SR-A type I (SR-AI), as prominent scavenger receptors on mediating oAβ clearance by microglia while glycan moiety and scavenger receptor cysteine-rich (SRCR) domain may play the critical role. Macrophage receptor with collagenous structure (MARCO), another member of class A superfamily with a highly conserved SRCR domain, may also play the similar role on oAβ internalization. However, the role of N-glycosylation and SRCR domain of SR-AI and MARCO on oAβ internalization remains unclear. We found that oAβ internalization was diminished in the cells expressing SR-AI harboring mutations of dual N-glycosylation sites (i.e. N120Q-N143Q and N143Q-N184Q) while they were normally surface targeted. Normal oAβ internalization was observed in 10 SR-AI-SRCR and
Background: Obesity is associated with an adverse cardiovascular outcome. While high-density lipoprotein cholesterol (HDL-C) is often decreased in the setting of obesity, little is known regarding the potential impact of HDL functionality. The current study investigated the impact of obesity on scavenger receptor B1 (SR-B1) mediated serum cholesterol efflux.. Methods: 55 apparently healthy obese subjects (BMI,=30kg/m2) and 17 normal weight subjects underwent physical examination and fasting blood draw. The subject with history of diabetes and cardiovascular disease, and on the treatment of dyslipidemia was excluded. Serum lipid profile and capacities of serum to promote cholesterol efflux with SR-BI expressing Fu5AH hepatoma cells were examined.. Results: The characteristics of the entire cohort was, age 48.1±11.1 years, BMI 34.1±9.0, waist circumference 100.3±16.7cm, LDL-C 120.4±24.5mg/dL, HDL-C 50.1±12.3mg/dL and triglycerides 116±58.9mg/dL. While increased SR-B1 mediated cholesterol ...
Recognition by scavenger receptor cysteine-rich domains on membrane proteins regulates innate and adaptive immune responses. Two receptors expressed primarily on T cells, CD5 and CD6, are linked genetically and are structurally similar, both containing three scavenger receptor cysteine-rich domains in their extracellular regions. A specific cell surface interaction for CD5 has been difficult to define at the molecular level because of the susceptibility of CD5 protein to denaturation. By using soluble CD5 purified at neutral pH to preserve biological activity, we show that CD5 mediates species-specific homophilic interactions. CD5 domain 1 only is involved in the interaction. CD5 mAbs that have functional effects in humans, rats, and mice block homophilic binding. Ag-specific responses by mouse T cells in vitro were increased when engagement of human CD5 domain 1 was inhibited by mutation or by IgG or Fab fragment from a CD5 mAb. This showed that homophilic binding results in productive ...
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One-fifth of the pupils in class B and seven-eighth of those in class A were girls. After George reshuffled an equal number of pupils between the two classes, the number of boys in each class became the same as the number of girls. A total of 24 pupils were affected. How many pupils were there in both classes at first ...
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Enterovirus 71 (EV-A71) is now the most common neurotropic enterovirus. It causes Hand, Foot, and Mouth Disease (HFMD) and occasional outbreaks of severe neurological deficits in infected children. Current animal infection models using NHPs and rodents recapitulate some features of the wide clinical spectrum of illnesses induced by EV-A71 infection in humans. However, none of these recapitulates the key clinical and pathological features of EV-A71-induced neurogenic pulmonary edema (NPE) observed in majority of fatal human cases. We developed an infection model by inoculating one-week-old BALB/c mice with novel viral strains that productively infect rodent and primate cell lines. These mouse-cell-adapted (MCA-EV-A71) strains were generated by serial passage of a brainstem clinical isolate (EV71:BS) in a murine embryonic fibroblast (NIH/3T3) cell line. These strains infected rodent cell lines using the physiologically expressed EV-A71 receptor, SCARB2 (Scavenger Receptor Class B, Member-2). In ...
article{a4a89a77-6245-40ad-adfc-12ba8e92c5b8, abstract = {OBJECTIVE: Atherosclerosis is an inflammatory disease. Several chemokines are important for monocyte/macrophage and T-cell recruitment to the lesion. CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR-PSOX, which mediates uptake of oxidized low-density lipoprotein. We investigated whether CXCL16 expression is controlled by interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions. METHODS AND RESULTS: CXCL16 and CXCR6 expression was identified by polymerase chain reaction and histochemistry in atherosclerotic lesions from humans and apolipoprotein-E-deficient mice. In vitro IFN-gamma induced CXCL16 in human monocytic THP-1 cells and primary human monocytes, which led to increased uptake of oxidized low-density lipoprotein in THP-1 cells, which could be ...
Abcam provides specific protocols for Anti-Macrophage Scavenger Receptor I antibody (ab123946) : Immunohistochemistry protocols, Immunocytochemistry &…
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Discussion. The results suggest that the largest community of scavengers is present during the first 11 days of access, when the carcasses contain the most meat. The longer the amount of time that has passed, the less meat is available to the scavengers. By Day 12, when bones were visible on the carcasses, the three most common scavengers dropped in number significantly (p = 0.0003). Hooded vultures remained at a relatively constant average across the days, suggesting they do not have a preference for which part of the carcass they consume.. The largest of the avian scavengers, the marabou stork, was the most common scavenger for the majority of the time at the carcasses. Given that it has the greatest body mass, of 9 kilograms, the marabou stork most likely had dominance over the scavenger guild and therefore remained at the carcasses for the longest amount of time (Wallace, 1987). The smallest avian scavenger, the sacred ibis (1.35 kilograms), would therefore have the least amount of dominance ...