Mosquitoes are able to adapt to feed on blood by the salivary glands which created a protein that works against the haemostasis process. This study aims to investigate the salivary glands proteins expression of 50 adult female An. dirus A mosquitoes, a main vector of malaria in Thailand, each group with an age of 5 days which were artificial membrane fed on sugar, normal blood, blood infected with P. vivax, and blood infected with P. falciparum. Then mosquito salivary gland proteins were analyzed by SDS-PAGE on days 0, 1, 2, 3, and 4 after feeding. The findings revealed that the major salivary glands proteins had molecular weights of 62, 58, 43, 36, 33, 30, and 18 kDa. One protein band of approximately 13 kDa was found in normal blood and blood infected with P. vivax fed on day 0. A stronger protein band, 65 kDa, was expressed from the salivary glands of mosquitoes fed with P. vivax- or P. falciparum-infected blood on only day 0, but none on days 1 to 4. The study shows that salivary glands proteins
Analyses of T cell receptors (TCR) on T cells infiltrating labial salivary glands of patients with Sjögrens syndrome (SS) indicate that the cells expand by antigen stimulation in context of major histocompatibility complex (MHC). To elucidate the autoantigens recognized by T cells infiltrating in labial salivary glands from patients with SS, proteins derived from human salivary gland cDNA libraries were screened by West-Western method using TCR-CDR3 probe, which is antigen recognition region of TCR on T cells. 13 cDNA clones were detected as proteins binding to TCR-CDR3 region. One was a human alpha-amylase salivary precursor (AA54-407), suggesting that alpha-amylase might be a salivary gland-specific autoantigen. To examine whether alpha-amylase acts as an antigen in labial salivary glands, PBL from 11 patients with SS were incubated with 9 different synthetic amino acids of alpha-amylase or salivary alpha-amylase. SSCP analysis on TCR clearly showed that alpha-amylase reactive T cells were ...
Fingerprint Dive into the research topics of Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. Together they form a unique fingerprint. ...
1. Hall JE. Secretory functions of the alimentary tract. In Hall JE, ed. Guyton & Hall Textbook of Medical Physiology, 12th ed. Philadelphia: Saunders Elsevier. 2011:773-776 2. Hector MP, Linden RWA. Reflexes of salivary secretion. In: (ed.) Garrett JR, Ekstrom J, Anderson LC. Neural Mechanisms of Salivary Gland Secretion. Basel: Karger. 1999:196-217 3. Melvin JE, Yule D, Shuttleworth T, Begenisich T. Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Ann Rev Physiol. 2005;67:445-469 4. Smith PM. Mechanisms of salivary secretion. Edgar M, Dawes C, OMullane D, eds. Saliva and Oral Health, 4th ed. London: Stephen Hancocks Ltd. 2012:17-36 5. Wong DT. In: Wong DT, ed. Salivary Diagnostics. Iowa: Wiley-Blackwell. 2008:14-37 6. Baum BJ, Wellner RB. Receptors in salivary glands. In: (ed.) Garrett JR, Ekstrom J, Anderson LC. Neural mechanisms of salivary gland secretion. Basel: Karger. 1999:44-58 7. Catalán MA, Nakamoto T, Melvin JE. The salivary gland fluid secretion ...
Salivary gland infections occur as painful swellings of any of the salivary glands. The parotid glands are located under the skin in front of the ear overlying the jaw bone, and the submandibular glands are located underneath the jaw. All of these glands produce saliva which is useful for chewing, swallowing, and maintenance of proper oral health.. Salivary gland infections occur when bacteria infect the normal salivary gland anatomy. When this occurs in the parotid gland it may cause painful fullness or swelling in front of the ear. When this occurs in a submandibular gland, painful tenderness may be felt below the jaw or in the neck. Infections are more likely to occur during times of dehydration when less saliva is made. Infections may be limited in nature, lasting only a period of days, or chronic, lasting for weeks.. Salivary gland infections are commonly treated with increasing water intake and massage. Increasing the saliva production by sucking on lemon wedges or hard candy may help as ...
Radiotherapy of malignancies in the head and neck often involves the major and minor salivary glands in the radiation field. Adverse effects, such as dry mouth symptoms, are common after such therapy. The aim of this thesis was to study longitudinal effects of fractionated irradiation to the head and neck on salivary gland function in man and in the rat and to test radioprotection from antioxidant vitamins (retinol, a-tocopherol and ^-carotene).. A sharp decrease in parotid saliva flow rate was seen after one week of irradiation in cancer patients, but in some patients recovery was seen two months after completed treatment. Loss and recovery of salivary gland function were dependent on the total dose given. Irradiation with doses of ,65 Gy to the parotid glands led to permanent loss of function in the majority of parotid glands, while recovery could be seen after irradiation with doses of ,52 Gy. Concentrations of some proteins and electrolytes in saliva were increased during irradiation but no ...
Here we show that a gain-of-function screen looking for factors affecting a process of epithelial morphogenesis, that is, the formation of the salivary glands in the Drosophila embryos, was efficient in identifying a range of known and new players. The screen was designed to identify genes that are endogenously expressed in the glands and where overexpression or antisense expression by an EP element interfered with endogenous function. The screen could also identify genes not endogenously expressed in the glands but with an apparent overexpression phenotype that uncovered a potential function for this gene in cell shape or cytoskeletal regulation elsewhere. Genes falling into all of these classes have been identified in the screen. We show that factors with a variety of proposed functions can affect salivary gland invagination-from cytoskeletal components via signaling factors (some of which impinge on the cytoskeleton themselves) to microRNAs and novel uncharacterized proteins. Most of the ...
The basement membrane separates the epithelium from the surrounding mesenchyme and plays an essential role in the development of various epithelial-mesenchymal organs. Among these, the submandibular salivary gland (SMG) has been chosen to review the expression patterns and roles of the epithelial...
The generation and maintenance of correct lumen size and shape is essential for the function of tubular organs. Now, Monn Monn Myat and co-workers report that p21-activated kinase (Pak1) plays a novel role during lumen formation in Drosophila embryonic salivary glands (see p. 4177). The researchers show that Pak1 regulates the size and elongation of the apical domain of individual epithelial cells in the developing gland by decreasing and increasing E-cadherin levels at adherens junctions and basolateral membranes, respectively. Pak1 mediates these effects, they report, through Rab5- and Dynamin-dependent endocytosis of E-cadherin. Moreover, constitutively active Pak1 induces the formation of multiple intercellular lumens in the gland, an effect that is dependent on Rab5 and Dynamin, and on the Pak1 substrate Merlin. Together, these results identify a crucial role for Pak1 and E-cadherin endocytosis in lumen size and shape determination in fly salivary glands, and highlight a mechanism for ...
Purpose: To examine effects and mechanisms of transient activation of Hedgehog pathway on rescuing radiotherapy-induced hyposalivation in head and neck cancer survivors. Experimental Design: Mouse salivary glands and cultured human salivary epithelial cells were irradiated by single 15Gy dose. Hedgehog pathway was transiently activated in mouse salivary glands by shortly over-expressing Sonic hedgehog (Shh) transgene or administrating Smoothened Agonist and in human salivary epithelial cells by infecting with adenovirus encoding Gli1. Activity of Hedgehog signaling was examined by expression of Ptch1-lacZ reporter and endogenous Hedgehog target genes. Salivary flow rate was measured following pilocarpine stimulation. Salivary stem/progenitor cells (SSPCs), parasympathetic innervation and expression of related genes were examined by flow cytometry, salisphere assay, IHC, quantitative RT-PCR, Western blot and ELISA. Results: Irradiation does not activate Hedgehog signaling in mouse salivary ...
In recent years, an increase in the number of CT and MRI scans has been recorded for first-line diagnosis in patients with tumor-like lesions of the salivary glands at the outpatient care of an ENT-department (university hospital). 30.7% of the patients with tumor-like lesions in salivary glands underwent an imaging procedure - MRI or CT - prior to US and in about 11.0% of the patients CT scans lack standards like intravenous contrast or a slice thickness of 5 mm or less. Besides data presentation, the present study has been performed to highlight several issues explaining this phenomenon. Especially, one issue addresses the key question, whether MRI, CT and US devices of the newer generation were more valid to deduct the correct diagnosis with special focus on the nature of the tumor lesion (benign/malignant).. According to our study population, the percentage of CT and MRI scans with standard quality for first-line diagnosis in patients with tumor-like lesions of the salivary glands ranged ...
Salivary gland diagnostics. Salivary gland X-ray (sialography) of a human head, showing the submandibular gland. This is a paired salivary gland found below the lower jaw bone (mandible). Here, a contrast medium has been injected to show the salivary ducts which secrete saliva. This can be done to diagnose certain disorders. - Stock Image C010/5967
As a hematophagous parasite, anticoagulants are crucial for L. salmonis. In hematophagous animals specific anticoagulants are produced by salivary gland in order to keep the blood liquid and to allow the parasite to process it properly. Such proteins are unknown in L. salmonis as well as its site of expression. At the same time the function of the salivary gland as production of anticoagulant factors has not been confirmed in L. salmonis. Genes with Kunitz domain are typically proteinase inhibitors and some are involved in anticoagulation. They are present in L. salmonis but with unknown function and site of expression. This studied demonstrated the presence of two salivary gland specific genes belonging to the Kunitz family and other highly expressed in the intestine. The silencing of these genes did not give any distinct phenotypes in adults or larvae stages. The present study could not conclude if the three investigated genes are involved in anticoagulation in the salmon louse. However, the ...
fc33f3: (Left) Salivary gland, (SEM). From Nagato, T. (Right) Salivary gland, fluorescence micrograph. From Emerman, J. and W. Vogl. By permission of Don Fawcett. ...
MCMV has broad tissue tropism, and can infect the hosts epithelial cells such as salivary gland tissue, as well as macrophages and lymphoid cells. In natural infections, no clinical symptoms may be detected. The submandibular salivary gland is the primary site of lesions; other salivary glands are rarely involved. A substantial percentage of infected mice may eventually develop latent infections, and the virus may be transmitted to other mice through biting ...
salivary glands (săl´əvâr´ē), in humans, three pairs of glands that secrete the alkaline digestive fluid, saliva, into the mouth. Most animals have salivary glands that resemble those in humans; however, in some animals these glands perform other functions.
Salivary gland: Salivary gland, any of the organs that secrete saliva, a substance that moistens and softens food, into the oral cavity of vertebrates. Salivary glands may be predominantly serous, mucous, or mixed in secretion. Mucus is a thick, clear, and somewhat slimy substance. Serous secretion is a more
Salivary gland stones are deposits of carbon, calcium phosphate, and other minerals that can build up in the salivary glands and...
Abstract. The oral cavity is a moist environment, a film of fluid called saliva constantly coats its inner surfaces and occupies the space between the lining oral mucosa and the teeth. Saliva is a complex fluid, pro-duced by the salivary glands, whose important role is maintaining the wellbeing of the mouth. Patients with a deficiency of salivary secretion experience difficulty eating, speaking, swallowing as well as become prone to mucosal infections and rampant caries. In human there are three pairs of major encap-sulated salivary glands - (parotid, submandibular, and sublingual). Located outside the oral cavity, with extended duct systems to discharge their secretion. There are also a multitude of smaller minor unen-capsulated salivary glands. (labial, lingual, palatal, buccal, glossopalatine and retromolar). Located just below and within the mucous membranes, characterized by short duct systems. Secretion of each major salivary gland is not the same, the parotid glands secrete a rich amylase ...
The introduction of aggressive multi-modality treatments have helped cancer survivors live longer than before. Many cancer treatments have deleterious side-effe...
Salivary glands are located in the jaws of the lower part of the head, and are at the edges of the head (Brain) CT scans simulated in this study. Extension of the scan range inferiorly includes more or even the entire glands into the head scans. The dose to the glands can be 7.5 times of the default dose after an inferior extension of 3 cm for new-born (0-year-old) patients. For older patients, a 3-cm extension can still increase the dose to the glands by more than 2 times. With a 1-cm inferior extension or a 1-cm superior retraction, the dose to the glands can be doubled or halved, indicating the salivary gland dose is very sensitive to the location of the inferior edge of the head scan. Comparing the doses with 3cm superior retraction and the doses with 3cm inferior extension of the inferior range, the changes in salivary gland dose can be 27 times for newborn patients and 13 times for adults. The inferior extension of head scan range increases the salivary dose, and the extension is up to 8cm ...
Physiological saline was injected into the efferent duct of the parotid salivary gland of cats under a pressure of 30, 70, and 120 cm water. It was shown by the use of transmission electron...
The saliva is a mixture of secretions of the salivary gland and gingival fluid exudates. It is slightly alkaline and consists of water and 0.58% solids. Saliva has many functions. It serves as protection for it is a lubricant. Its glycoprotein content ...
Question - History of salivary gland removal. Have sore tongue, pus discharge from surgery site, painful. What could this be?. Ask a Doctor about Oral hygiene, Ask a Dentist
Acute inflammation of the salivary glands is usually of viral or bacterial origin. Of the viral illnesses, mumps is the most common. This (...)
List of 357 causes for Face blueness and Salivary gland symptoms, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Over the past 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes the most diagnostic challenges and problems fo
Learn more about Salivary Gland Surgery at Reston Hospital Center DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
Study Salivary Glands flashcards from Faith Villaceran's University of the East class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
It all starts with a mosquito bite. When a hungry mosquito pierces someones skin to gorge herself, she also pumps in her saliva to stop the blood from clotting. Far too often, microscopic stowaways hiding in the insects salivary glands also make the trip, crossing over into the victims bloodstream to look for a new…
Supplementary MaterialsSupplementary Information srep38717-s1. involved with modulating Th2 cytokines and changing autoantibody information while changing plasma cell and germinal middle B cell populations in feminine and man SjSs mice. The scholarly research demonstrates a pivotal function of IL-17 and Th17 cells in the pathogenesis of SjS, and more that IL-17 displays a sex difference in the condition procedure importantly. Outcomes IL-17 is involved with salivary gland function of man and feminine B6 directly.NOD-mice IL-17 levels are highly raised in the salivary Troglitazone glands of individual with SjS and pet style of SjS8. The upregulation of IL-17 provides been proven to correlate with the severe nature from the disease15, while short-term blockage of IL-17 in the glands using gene therapy provides improved a number of the scientific signals in spontaneous SjSs-B6.NOD-mice13. Latest data possess indicated that Th17 cells are vital in the introduction of SjS within an immunized SjS ...
The start of digestion commences with digestive enzymes secreted by salivary gland cells into our mouths. Cells lining the gastrointestinal tract also contribute enzymes including pepsin while in the abdomen. Moreover, digestive enzymes are developed in the pancreas and therefore are emptied into the more info upper Portion of the modest intestine. These enzymes assist to interrupt apart proteins, starch, lactose and fats, enabling the human body to optimise its hard work to digest foodstuff ...
The start of digestion commences with digestive enzymes secreted by salivary gland cells into our mouths. Cells lining the gastrointestinal tract also add enzymes which include pepsin during the belly. Furthermore, digestive enzymes are manufactured while in the pancreas and are emptied into your higher part of the smaller intestine. These enzymes aid to break aside proteins, starch, lactose and fats, allowing the human body to optimise its effort and hard work to digest food ...
Identification of Candidate Sialome Components Expressed In Ixodid Tick Salivary Glands Using Secretion Signal Complementation In Mammalian ...
Immunohistochemistry: STK39 Antibody [NBP2-49347] - Staining of human salivary gland shows strong cytoplasmic and nuclear positivity in glandular cells ...
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Stem cells are the cells that are responsible for the maintenance of tissues and organs by replacing functional cells with a limited life-span or that are damaged beyond repair.
News Analysis The Rising Research Profile of 23andMe An exploration of the genetics of earlobe attachment is just the latest collaborative research project to come out of the personal genetic testing company.. ...
The Department of Energy requested that scientists reword grant proposals to be more in line with the White Houses agenda on climate research.. 0 Comments. ...
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Gland Surgery publishes articles in the field of translational research in gland surgery, provides current and practical information on diagnosis, prevention and clinical investigations of gland surgery.
We read with great interest the article by Lin et al that provided the clue for a pathogenic role of T helper (h) 17 cells in the development of experimental Sjögrens syndrome (SS).1 In particular, interleukin (IL)-17 knockout C57BL/6 mouse immunised with salivary glands (SGs) proteins does not display clinical, histological and serological features of SS as the wild type counterpart.1 Previous studies reported that the infusion of adenovirus vectors expressing IL-17 into SGs, via retrograde cannulation, was able to induce clinical, serological and histological features of SS in non-susceptible mice, thereby suggesting a pathogenic role of this cytokine in the induction of glandular damage in SS.2 To date, it is still a matter of … ...
2017: INRA young researcher grant, Cholinergic signaling pathways in the salivary gland of Ixodes ricinus, 10,000 euros, PI -Ladislav Simo ...
sterile, easy-to-use, non-invasive swabs that works for you and your donor. Our sterile swabs come in many different shapes and sizes. Weve outlined three of the most widely-used types in the field today. One of swab is flocked swab, it has been adopted into the field of genetics due to the superior nature of their nylon flocked Providing a unique alternative to the cotton or foam, these flocked fibers are able to collect, retain, and elute the sample, even when cell counts are limited.. We have found that flocked swabs are gentle enough to use on newborns who may or may not have developed salivary glands yet. The nylon flocked will gently attract the buccal and/or saliva cells within the mouth.. ...
ICD-9 code 521.34 for Erosion, localized is a medical classification as listed by WHO under the range - DISEASES OF ORAL CAVITY, SALIVARY GLANDS, AND
Thanks to intravital microscopy, an optical imaging technique, Weigert and colleagues were able to determine for the first time how exocytosis actually occurs in the salivary glands of a living mouse.
View list of generic and brand names of drugs used for treatment of Swollen Glands. You can find more information including dosage, side effects of the Swollen Glands medicine.
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Salivary gland impairment after radioiodine therapy (RIT) is a well-known iatrogenic artifact that includes recurrent episodes of sialadenitis, hyposalivation, dysgeusia, and dysphagia. Several therapy modalities have been suggested over the years to decrease these effects on the salivary glands. However, in cases where the salivary gland system is impaired prior to RIT, preserving its function becomes more challenging. We present three patients who underwent RIT with pre-existing insult to the salivary glands and discuss the treatment modality employed. A protocol for treating patients with pre-existing salivary gland impairment prior to RIT is proposed. The dental professional personnel should be aware of RIT insult to the salivary glands in order to preserve more maliciously the oral health in these patients. Management of impaired salivary glands subjected to additional RIT is mandatory to reduce further damage to the glands function primarily by combining interventional sialoendoscopy for ...
Looking for online definition of salivary glands in the Medical Dictionary? salivary glands explanation free. What is salivary glands? Meaning of salivary glands medical term. What does salivary glands mean?