Abstract Introduction: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. Case Report: A 16-year-old male presented with recurrent painless swelling in the right preauricular region and with a history of surgical intervention at the same site in the past. His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a superficial parotidectomy was performed. The detailed histopathological examination was suggestive of Polymorphous low grade adenocarcinoma. In view of close margins, the patient was given adjuvant radiotherapy. Thirty-three months post-surgery, he is alive and disease-free. We describe a rare case of PLGA of the parotid gland in a teenager with its clinical characteristics, histopathological
Learn about salivary gland cancer treatment advances. New radiation therapy technology has resulted in improved treatment of salivary gland cancer.
Treatments for salivary gland cancer include surgery and radiation. Learn about treatment plans and options for salivary gland cancer.
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Adenoid Cystic Carcinoma, Minor Salivary Gland Cancer is back/Recurred Oh No Gabbymom04 - WhatNext.com - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
TY - JOUR. T1 - Long-term outcomes of surgery followed by radiation therapy for minor salivary gland carcinomas. AU - Zeidan, Youssef H.. AU - Shultz, David B.. AU - Murphy, James D.. AU - An, Yi. AU - Chan, Cato. AU - Kaplan, Michael J.. AU - Colevas, A. Dimitrios. AU - Kong, Christina. AU - Chang, Daniel T.. AU - Le, Quynh Thu. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Objectives/Hypothesis Postoperative radiation therapy is often used in patients with high-risk salivary gland carcinomas. In this study we evaluated the outcomes and prognostic factors in patients with minor salivary gland cancers treated with adjuvant radiation therapy. Study Design Retrospective cohort study. Methods We performed a retrospective analysis of 90 patients treated with curative intent. Median follow-up was 71 months. Fifty-eight patients (64%) had adenoid cystic carcinomas, 22 (24%) had adenocarcinomas, and 10 (11%) had mucoepidermoid cancers. Primary disease site included 39 (43%) sinonasal, 35 (39%) oral cavity, 10 ...
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Most people with salivary gland cancer will have radiation therapy, alone or with other treatments. Learn about radiation therapy for salivary tumours.
ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Nets Guide to Salivary Gland Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.About the salivary glandsThe salivary glands contain tissues that produce saliva. Saliva is important to the
Layne Compston wasnt born yet when his mother was diagnosed with throat cancer as a teenager. But hes learned a lot from hearing about that experience and watching her deal with salivary gland cancer more recently.
Surgical treatment of salivary gland cancer with surgical resection (costs for program #138151) ✔ University Hospital Münster ✔ Department of Otolaryngology ✔ BookingHealth.com
Surgical treatment of salivary gland cancer with surgical resection (costs for program #121533) ✔ Merian Iselin Clinic ✔ Department of Otolaryngology ✔ BookingHealth.com
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Information on salivary gland cancer, including how it is diagnosed, treatments you might have, possible side effects and how to get further support.
Immunostaining for p63, p504S and the androgen receptor status are important markers for carcinomas of the prostate. The purpose of this study was to investigate the staining characteristics of these markers for malignancies of salivary gland origin. Wax blocks of 32 malignant salivary gland neoplasms were retrieved, sections prepared and stained by the H&E method and immunoperoxidase techniques for the demonstration of p63 (Dako N1604), p504S (Dako N1609) and androgen receptors (Dako M3562). The sections were viewed by light microscopy and positivity scored with the aid of a grading scale. Androgen receptor- and p504S positivity were infrequently observed in the study samples, except for salivary duct carcinoma and mucoepidermoid carcinoma where most of the cases stained positive for p504S. The staining pattern of adenoid cystic carcinomas for p63 correlated with the microscopic subtype. The basal- and intermediate cells of mucoepidermoid carcinomas stained positive- and the mucus- and epidermoid
We hypothesized that lymph node involvement in minor salivary gland cancers is associated with clinical and pathological factors commonly available to the clinician after a typical initial workup. Our aim was to identify these factors using a dataset that allowed us to compile the largest series of minor salivary gland cancers in the published literature. Using this dataset we also aimed to characterize the distribution of histological types by primary site, identify the predictors of the use of external beam radiation therapy and neck dissection, and examine the effect of lymph node involvement on survival. Using the SEER database, we identified 2667 minor salivary gland cancers with known lymph node status from 1988 to 2004. Univariate and multivariate analyses were conducted to identify factors associated with the use of neck dissection, the use of external beam radiation therapy, and the presence of cervical lymph node metastases. Kaplan Meier survival curves were constructed to examine the effect
ENGLISH SUMMARY : Background: Success rates in the treatment of salivary gland malignancies are associated with completeness of surgical resection with or without postoperative radiotherapy. For patients with unresectable tumours, radiotherapy is an option to attempt to gain local control and improve survival. Different modalities of radiotherapy are available and fast neutrons represent a form of radiotherapy effective in controlling locally advanced salivary gland malignancies. We report on 22 patients treated for locally advanced parotid gland malignancies at iThemba Laboratory for Accelerator Based Sciences via a tertiary institution in Cape Town, South Africa. Methods: Records of patients with unresectable parotid gland malignancies treated with neutron radiotherapy at a tertiary institution between January 1991 and December 2012 were reviewed retrospectively. Twenty-two patients were eligible for statistical analysis. Results: Complete, partial and no response rates were 64%, 14% and 22%, ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support. ...
Salivary gland tumors are more likely to be cancerous in children when compared to adults. About half of the salivary gland tumors are cancerous in children. Most of the tumors occur in a salivary gland called parotid gland (located at the angle of the jaw below the ear lobes on both sides). The types of cancerous salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma and adenocarcinoma NOS.. ...
Find the best parathyroid gland cancer doctors in Bangalore. Get guidance from medical experts to select parathyroid gland cancer specialist in Bangalore from trusted hospitals - credihealth.com
MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug ...
Lymphomas and benign lymphoepithelial lesion. Lymphomas of the major salivary glands are characteristically of the non-Hodgkin type. In an AFIP review of case files, non-Hodgkin lymphoma accounted for 16.3% of all malignant tumors that occurred in the major salivary glands; disease in the parotid gland accounted for about 80% of all cases. [3]. Patients with benign lymphoepithelial lesion (e.g., Mikulicz disease), which is a manifestation of the autoimmune disease, Sj gren syndrome, are at an increased risk for development of non-Hodgkin lymphoma. [80] [81] [82] [83] [84] Benign lymphoepithelial lesion is clinically characterized by diffuse and bilateral enlargement of the salivary and lacrimal glands. [23] Morphologically, a salivary gland lesion is composed of prominent myoepithelial islands surrounded by a lymphocytic infiltrate. Germinal centers are often present in the lymphocytic infiltrate. [23] Immunophenotypically and genotypically, the lymphocytic infiltrate is composed of ...
The TNM classification for cancer of the major salivary glands (parotid, submandibular, and sublingual) is provided below, along with anatomic staging. Table.
This is a single agent, prospective, open-label, monocenter, phase II trial of sorafenib in patients with recurrent and/or metastatic salivary gland carcinoma. This trial will be conducted with the primary aim to determine the response rate (CR+PR) according to the RECIST criteria. Response rate according to CHOI criteria, correlation between CHOI criteria and outcome, disease Control Rate (DCR) and acute toxicity will be evaluated as secondary objectives ...
Carcinoma of the minor salivary gland (MSG) prognosis is associated with histologic subtype, tumor subsite, age at the time of diagnosis.
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Nicholas Kalavrezos is a head and neck reconstructive surgeon and the lead clinician in the Head and Neck Centre at UCLH with a background in oral and maxillo-facial surgery. Mr Kalavrezos is also the lead head and neck sarcoma surgeon for the London Sarcoma Service. His clinical practice includes ablative and reconstructive surgery for the head and neck with a special interest in bone sarcomas and functional outcomes following reconstructive surgery. His clinical practice also includes surgical treatment of salivary gland tumours as well as thyroid surgery.. Mr Kalavrezos research interests include applications of tissue engineering in head and neck reconstruction. He is a founding member of the Centre for Reconstructive Surgery at University College London (UCL) where he also holds a senior lecturer post. He is also a member of the Face Transplant Group based at the Royal Free Hospital aiming to perform the first face transplant in the UK. He has joint research projects in the ...
Learn about this rare form of cancer affecting the salivary glands and salivary gland treatments such as surgery and radiation therapy.
Carbon monoxide and nitric oxide are two of the most important vasoprotective mediators. Their downregulation observed during vascular dysfunction, which is associated with cancer progression, leads to uncontrolled platelet activation. Therefore, the aim of our studies was to improve vasoprotection and to decrease platelet activation during progression of mouse mammary gland cancer by concurrent use of CO and NO donors (CORM-A1 and DETA/NO, respectively).. Methods: Mice injected intravenously with 4T1-luc2-tdTomato or orthotopically with 4T1 mouse mammary gland cancer cells were treated with CORM-A1 and DETA/NO. Ex vivo aggregation and activation of platelets were assessed in the blood of healthy donors and breast cancer patients. Moreover, we analyzed the compounds direct effect on 4T1 mouse and MDA-MB-231 human breast cancer cells proliferation, adhesion and migration in vitro.. Results: We have observed antimetastatic effect of combination therapy, which was only transient in orthotopic ...
View details of top pituitary gland cancer hospitals in Navi Mumbai. Get guidance from medical experts to select best pituitary gland cancer hospital in Navi Mumbai
If youre just joining us, here are the Spark Notes:. In September, Carolyn had surgery to remove what we thought was an enlarged lymph node in her jaw that had become painful. We discovered that it was actually a rare, destructive salivary gland cancer. With that news, doctors order a PET scan to determine abnormal activity. In addition to the area of that one salivary gland, the back of her tongue/tonsils and several lymph nodes in her abdomen/groin area showed up as active.. We had known something was up in her abdomen/groin area because for a couple of months prior, shed been experiencing pain and soreness. Doctors had attributed that to enlarged lymph nodes due to sarcoidosis.. After consultation with doctors here in Blacksburg and at Wake Forest Baptist, Carolyn had a second surgery to make sure all the initial salivary gland cancer was removed. At that time they also took tissue from her tongue/tonsils area to study.. That was last Tuesday. On Thursday, she went in to her local ENT here ...
You will need regular checkups of your face, mouth, throat and neck after treatment for salivary gland cancer. This will include a physical exam. Some patients may also need imaging of their mouth using CT, MRI and PET scans, however, most patients with salivary gland cancer wont need this. It is important to see your cancer care team for regular follow-up visits to make sure that if the cancer comes back it is caught early and can be treated. If you have any concerns between appointments you should contact your doctor. Ask your doctor whether this is needed for you.. Mental health for people with cancer Sometimes this is referred to as psychosocial aspects or survivorship ...
TY - JOUR. T1 - Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation. AU - Varsegi, Mary F.. AU - Ravis, Scott M.. AU - Hattab, Eyas M.. AU - Henley, John D.. AU - Billings, Steven D.. PY - 2008/6. Y1 - 2008/6. N2 - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease. To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.. AB - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a ...
To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference ( ...
1. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 4th ed. Lyon, France: IARC Press. 2017 (WHO Classification of Tumors; vol. 9) 2. Jayaprakash V, Merzianu M, Warren GW. et al. Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database. Head Neck. 2014;36:694-701 3. Boon E, Boxtel W van, Buter J. et al. Androgen deprivation therapy for androgen receptor-positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands. Head & Neck. 2018;40:605-13 4. Limaye SA, Posner MR, Krane JF. et al. Trastuzumab for the treatment of salivary duct carcinoma. Oncologist. 2013;18:294-300 5. Dalin MG, Desrichard A, Katabi N. et al. Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer. Clin Cancer Res. 2016;22:4623-33 6. Luk PP, Weston ...
Aims: To assess lymphatic vascular density (LVD) and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in the different carcinogenesis phases and tumour progression.. Methods: In 8 cases of early CXPA (intracapsular and minimally invasive tumours), 8 of advanced CXPA (widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively.. Results: Comparing early tumours with advanced ones, LVD was not significantly different at the tumour margin. In contrast, regarding intratumoural lymphatics, PA without malignant transformation and early CXPA contained rare, if any, lymph vessels, whereas in widely invasive carcinomas they were more numerous. However, neither intratumoural nor peritumoural LVD were increased in comparison to adjacent normal salivary gland tissue. In no case did dual ...
Salivary adenoid cystic carcinoma (SACC) is one of the most frequent carcinomas derived from the salivary gland. Growing evidence implied the involvement of microRNAs (miRNAs) in SACC progression and metastasis. This study aimed to determine the regulatory role of miR-140-5p in SACC progression and metastasis and to explore the underlying mechanisms. MiR-140-5p and survivin mRNA expression levels were determined by quantitative real-time PCR; protein levels were evaluated by western blot assay; cell proliferation, growth, invasion, apoptosis and caspase-3 activity were evaluated by respective in vitro functional assays; xenograft nude mice model was used to assess the in vivo tumor growth; a luciferase reporter assay determined the interaction between miR-140-5p and survivin. MiR-140-5p overexpression suppressed SACC cell proliferation and invasion, induced cell apoptosis and inhibited in vivo tumor growth of SACC cells. The loss-of-function studies showed that miR-140-5p knockdown enhanced SACC cell
Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC). This study aims to decipher the prognostic and mechanistic role of PIM1 in progression of SACC cells and tumor tissues. A SACC cell line (ACC-M) was transfected with shRNA plasmids targeting the PIM1 gene. The expression levels of PIM1, RUNX3 and p21 were measured by quantitative real-time PCR and western blot. Subcellular translocalization of RUNX3 and p21 proteins was assessed using immunofluorescence, and cell cycle phase was quantified using flow cytometry. A total of 97 SACC patients were retrospectively analyzed by clinicopathologic characteristics and survival outcomes. After down-regulation of PIM1 in ACC-M cells, RUNX3 and p21 proteins were translocated from cytoplasm to nucleus, with a decrease of p21 expression and increase of G0/G1 phase cells. PIM1 and RUNX3 levels show a distinct
Acinic cell carcinoma (ACC) is a low-grade salivary gland malignancy characterized by serous acinar differentiation. Most ACCs arise in the parotid gland, but ACCs have been reported to originate in nonparotid salivary glands where serous acini are less abundant. Given the recent discovery of mammary analog secretory carcinoma (MASC)-a salivary malignancy that histologically mimics ACC-a retrospective reevaluation of nonparotid ACCs is warranted. The surgical pathology archives of The Johns Hopkins Hospital were searched for all ACCs arising outside of the parotid gland. For each case, the histologic slides were reviewed; immunohistochemical analysis (mammaglobin, S100 protein) was performed; and confirmatory ETV6 breakapart fluorescence in situ hybridization assay was completed. Demographic and clinical data were obtained from the medical records. Fourteen extraparotid tumors diagnosed as ACC were identified. Eleven of 14 (79%) tumors harbored the ETV6 translocation (oral cavity=9 of 11; ...
TY - JOUR. T1 - Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. AU - Roden, Anja C.. AU - García, Joaquín J.. AU - Wehrs, Rebecca N.. AU - Colby, Thomas V.. AU - Khoor, Andras. AU - Leslie, Kevin O.. AU - Chen, Longwen. N1 - Publisher Copyright: © 2014 USCAP, Inc. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. t(11;19)(q21;p13) is considered disease-defining for mucoepidermoid carcinoma; its significance in pulmonary mucoepidermoid carcinoma warrants further study. Forty three pulmonary mucoepidermoid carcinomas were ...
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic ...
TY - JOUR. T1 - Epithelial-myoepithelial carcinoma of the nasal cavity. AU - Lee, H. M.. AU - Kim, A. R.. AU - Lee, S. H.. PY - 2000. Y1 - 2000. N2 - A 22-year-old male presented with a 1-year history of nasal obstruction due to a polypoid mass in the right nasal cavity. Histopathologic examination revealed the tumor to consist of a mixture of a trabecular structure with a double-layered arrangement of inner dark cells and outer clear cells. Immunohistochemical examination showed the clear cells to be positive for α-smooth muscle actin and S-100 protein. Ultrastructural examination confirmed the myoepithelial cell origin. The tumor was excised and no recurrence or metastasis was found 40 months after surgery. We describe here a rare case of epithelial-myoepithelial carcinoma arising from the nasal cavity, one of the most unusual locations.. AB - A 22-year-old male presented with a 1-year history of nasal obstruction due to a polypoid mass in the right nasal cavity. Histopathologic examination ...
Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major salivary gland origin were examined for the presence of hyaline cells (plasmacytoid cells). Hyaline cells were found in 38 percent of the minor salivary gland cases and 21 perc …
TY - JOUR. T1 - Cystic major salivary gland lesions. T2 - Utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis. AU - Allison, Derek B.. AU - McCuiston, Austin M.. AU - Kawamoto, Satomi. AU - Eisele, David W. AU - Bishop, Justin A.. AU - Maleki, Zahra. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Introduction: The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularity and an incredibly broad differential diagnosis. The purpose of this study was to investigate the diagnostic utility of preoperative FNA cytology for cystic major salivary gland lesions. Methods and Materials: The electronic pathology archives of The Johns Hopkins Hospital were searched to identify FNA specimens of cystic major salivary ...
TY - JOUR. T1 - Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. AU - Schoenfeld, Jonathan D.. AU - Sher, David J.. AU - Norris, Charles M.. AU - Haddad, Robert I.. AU - Posner, Marshall R.. AU - Balboni, Tracy A.. AU - Tishler, Roy B.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Purpose: To analyze the recent single-institution experience of patients with salivary gland tumors who had undergone adjuvant intensity-modulated radiotherapy (IMRT), with or without concurrent chemotherapy. Patients and Methods: We performed a retrospective analysis of 35 salivary gland carcinoma patients treated primarily at the Dana-Farber Cancer Institute between 2005 and 2010 with surgery and adjuvant IMRT. The primary endpoints were local control, progression-free survival, and overall survival. The secondary endpoints were acute and chronic toxicity. The median follow-up was 2.3 years (interquartile range, 1.2-2.8) among the surviving patients. Results: ...
Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac and thyroid. Mucicarmine staining is one stain used by pathologist for detection. Occurs in adults, with peak incidence from 20-40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research. Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors. This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells. Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749. A possible ...
TY - JOUR. T1 - Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines. AU - Sato, Daisuke. AU - Kurihara, Yuji. AU - Kondo, Seiji. AU - Shirota, Tatsuo. AU - Urata, Yasuo. AU - Fujiwara, Toshiyoshi. AU - Shintani, Satoru. PY - 2013/12. Y1 - 2013/12. N2 - We evaluated the antitumor effect of a telomerase-specific replication-selective adenovirus (Telomelysin, OBP-301) for adenoid cystic carcinoma (ACC) in vitro and in vivo. Adenovirus E1 gene expression was controlled by human telomerase reverse transcription (hTERT). Infection of ACC cells by OBP-301 induced high E1A mRNA expression and subsequent oncolytic cell death in a dose-dependent manner. Using OBP-401 (TelomeScan), a genetically engineered adenovirus that carries the GFP gene under the control of the cytomegalovirus (CMV) promoter at the deleted E3 region of OBP-301, ACC cells expressed bright GFP fluorescence as early as 12 h after OBP-401 infection. The fluorescence ...
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TY - JOUR. T1 - Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. AU - Yamamoto, Yuzo. AU - Virmani, Arvind K.. AU - Wistuba, Ignacio I.. AU - McIntire, Donald. AU - Vuitch, Frank. AU - Albores-Saavedra, Jorge. AU - Gazdar, Adi F.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the p53 and RB genes and low or absent K-ras mutations and LOH at chromosomal loci 3p, 5q, 8p, and 9p. From 21 tumors, the authors carefully microdissected and analyzed 36 subtype foci. Three interrelated pieces of evidence indicate that the relatively poor ...
TY - JOUR. T1 - Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. AU - Weinreb, Ilan. AU - Piscuoglio, Salvatore. AU - Martelotto, Luciano G.. AU - Waggott, Daryl. AU - Ng, Charlotte K Y. AU - Perez-Ordonez, Bayardo. AU - Harding, Nicholas J.. AU - Alfaro, Javier. AU - Chu, Kenneth C.. AU - Viale, Agnes. AU - Fusco, Nicola. AU - Da Cruz Paula, Arnaud. AU - Marchio, Caterina. AU - Sakr, Rita A.. AU - Lim, Raymond. AU - Thompson, Lester D R. AU - Chiosea, Simion I.. AU - Seethala, Raja R.. AU - Skalova, Alena. AU - Stelow, Edward B.. AU - Fonseca, Isabel. AU - Assaad, Adel. AU - How, Christine. AU - Wang, Jianxin. AU - De Borja, Richard. AU - Chan-Seng-Yue, Michelle. AU - Howlett, Christopher J.. AU - Nichols, Anthony C.. AU - Wen, Y. Hannah. AU - Katabi, Nora. AU - Buchner, Nicholas. AU - Mullen, Laura. AU - Kislinger, Thomas. AU - Wouters, Bradly G.. AU - Liu, Fei Fei. AU - Norton, Larry. AU - Mcpherson, John Douglas. AU - Rubin, Brian ...
TY - JOUR. T1 - AKT3 drives adenoid cystic carcinoma development in salivary glands. AU - Zboray, Katalin. AU - Mohrherr, Julian. AU - Stiedl, Patricia. AU - Pranz, Klemens. AU - Wandruszka, Laura. AU - Grabner, Beatrice. AU - Eferl, Robert. AU - Moriggl, Richard. AU - Stoiber, Dagmar. AU - Sakamoto, Kazuhito. AU - Wagner, Kay Uwe. AU - Popper, Helmut. AU - Casanova, Emilio. AU - Moll, Herwig P.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of hybrid carcinomas that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related genes plus introns from 14 or 28 genes frequently rearranged for cancer and evaluated for all classes of GAs. Results: 590 GAs were found in 157 unique genes (mean 3.9/tumor). GAs in the PI3K/AKT/mTOR pathway were more common in SDC (53.6%) than other histologies (p=0.019) Cyclin dependent kinase GAs varied amongst all histotypes: adenocarcinoma, NOS (34.6%); SDC (12.2%); ca ex PA (16.7%); carcinoma, NOS (31.2%) (p=0.043). RAS GAs were observed: adenocarcinoma, NOS (17.3%); SDC (26.8%); ca ex PA (4.2%); and carcinoma, NOS (9.4%) (p=0.054). ERBB2 GAs, including amplifications and ...
Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been reported in Brazilian populations. Aim: To report clinical and pathologic data from 173 head and neck MEC treated in the Treatment and Research Center at Hospital do Câncer A. C. Camargo in São Paulo. Study design: Clinical randomized. Material and Method: From 1953 to 1997, 173 cases of MEC were found in the medical files of the center. Data were obtained from the patients records and histological review of all cases. Results: The mean age of the patients was 44 years and 93 (53.8%) were men; parotid glands were affected in 61 cases (35.2%) and intraoral minor salivary glands in 75 (43.4%). TNM revealed 50.3% of the cases in stages I and II, and histological grading revealed 45.2%, 18.5% and 36.3% low-grade, intermediate-grade and high-grade tumors, respectively. Surgical treatment was employed in 80.3% of the cases, with neck dissection in 52 cases (30.1%), and ...
Introduction Minor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study...
This most common malignant salivary gland tumour involves minor glands, and accounts for 9.5-23% of all minor gland tumours {669,704,2711}. About half of the cases arise in the palate and other common sites include the buccal mucosa, lips, floor of oral cavity and retromolar pad. They appear to be much more frequent in the lower lip than the upper lip {1871}. The tumour is often asymptomatic and detected during a routine dental examination.Many appear as bluish, domed swellings that resemble mucoceles or haemangiomas. Less commonly, the surface appears granular or papillary. Tumours of the base of tongue or oropharynx may cause dysphagia and sublingual tumours can lead to ankyloglossia and dysphonia. High-grade tumours are uncommon but can result in ulceration, loosening of teeth, paraesthesia or anaesthesia. Mucoepidermoid carcinoma is the most common salivary gland tumour to develop in a central location within the bone of the mandible or, less frequently, the maxilla {280}. The microscopical ...
NOTE: Phase II is complete. Phase II: 1. Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors; 2. Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin. Phase III: 1. Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone. Phase II/III Secondary Objectives: 1. Compare the acute toxicities of these 2 adjuvant treatments; 2. Compare late treatment-related adverse events in patients receiving postoperativeradiation to those receiving concurrent chemoradiation; 3. Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), and the patient cohort ...
Salivary gland tumors most commonly occur in the parotid gland, accounting nearly 85% of all salivary gland tumors. But, 25% of parotid tumors are malignant (cancerous).. Pleomorphic adenoma is the most common type of benign salivary gland tumor. It is typically a slow growing tumor and occur most often in the parotid gland. It is also known as mixed tumor which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements.. The tumor is usually solitary and presents as a slow growing, painless and firm singular nodal mass. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland.. ...
Free Online Library: Ceruminous gland adenoid cystic carcinoma with contralateral metastasis to the brain. by Archives of Pathology & Laboratory Medicine; Health, general Cancer metastasis Diagnosis Head and neck cancer Metastasis
Expertise, Disease and Conditions: Aerodigestive Disorders, Benign Thyroid Disorders, Benign Tumors of the Head and Neck, Carcinoma of the Tongue, Clinical Trials, Head and Neck Cancers, Head and Neck Conditions, Head and Neck Surgery, Head and Neck Tumors, Laryngeal Cancer, Melanoma, Minor Salivary Gland Cancers, Oral Cancers, Oral Cavity Cancers, Otolaryngology (ENT), Parathyroid Diseases, Parathyroid Surgery, Parotid Cancer, Parotid Gland Tumors, Robotic Surgery, Salivary Gland Tumors, Sentinel Lymph Node Biopsy, Sleep Apnea, Sleep Apnea Surgery, Thyroid Cancer, Thyroid Diseases, Thyroid Disorders, Thyroid Masses, Thyroid Surgery, Thyroid Tumors, Tongue Cancer, Tonsil ...
NOTOC__ {{Acinic cell carcinoma}} {{CMG}}; {{AE}} {{RG}} == Overview == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. == Primary Prevention == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. ==References== {{Reflist,2}} {{WH}} {{WS ...
Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term clinical outcomes and no targeted therapies are available. The majority of MEC tumors contain a t(11;19) chromosomal translocation that fuses two genes, CRTC1 and MAML2, to generate the chimeric protein CRTC1-MAML2. CRTC1-MAML2 displays transforming activity in vitro and is required for human MEC cell growth and survival, partially due to its ability to constitutively activate CREB-mediated transcription. Consequently, CRTC1-MAML2 is implicated as a major etiologic molecular event and a therapeutic target for MEC. However, the molecular mechanisms underlying CRTC1-MAML2 oncogenic action in MEC have not yet been systematically analyzed. Elucidation of the CRTC1-MAML2-regulated transcriptional program and its underlying mechanisms will provide important insights into MEC pathogenesis that are essential
Question - Swelling of submandibular salivary glands. Feel bumps on gland. Reason for swelling?. Ask a Doctor about diagnosis, treatment and medication for Salivary gland cancer, Ask an ENT Specialist
Salivary Gland Tumor Removal clinics in Romania at the best price. Find doctors, specialized in Ear, Nose and Throat (ENT) and compare prices, costs and reviews.
Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous glandular cells along with myoepithelial components, having a malignant potentiality. It is the most common type of salivary gland tumor and the most common tumor of the parotid gland. It derives its name from the architectural Pleomorphism (variable appearance) seen by light microscopy. It is also known as Mixed tumor, salivary gland type, which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements. The tumor is usually solitary and presents as a slow growing, painless, firm single nodular mass. Isolated nodules are generally outgrowths of the main nodule rather than a multinodular presentation. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland. When found in the parotid tail, it may present as an eversion of the ear lobe. Though it is ...
Background:. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrated that Pim-1 phosphorylates RUNX3 and alters its subcellular localization. As a highly malignant tumor, salivary adenoid cystic carcinoma (ACC) accounts for approximately 10% of all epithelial salivary tumors and the 5-year survival rate of patients with highly metastatic ACC is less than 20%. However, few studies have concerned the implications of Pim-1 in the salivary ACC.. Aim:. In this study, we aimed to clarify the function of Pim-1 in ACC cell lines in vitro. Meanwhile, we measure the levels of Pim-1 and RUNX3 in the ACC tissues. The correlations between Pim-1/RUNX3 levels and clinical parameters were also analyzed. Methods:. SACC-83 and SACC-LM cells were transfected with the Pim-1 siRNA. Pim-1 mRNA and protein expression were measured using real-time PCR and immnuoblot, ...
In a single-center phase II study reported in the Journal of Clinical Oncology, Tchekmedyian et al found that the multitargeted tyrosine kinase inhibitor lenvatinib was active in progressive recurrent or metastatic adenoid cystic carcinoma.. Study Details. In the study, 32 evaluable patients at Memorial Sloan Kettering Cancer Center with recurrent or metastatic adenoid cystic carcinoma of any primary site and radiographic or symptomatic progression were treated with lenvatinib 24 mg orally per day. Any prior therapy except lenvatinib was allowed.. The primary endpoint was overall response rate. The study was to be considered positive if 4 or more responses occurred among a total of 32 patients. Overall, 78% of patients had adenoid cystic carcinoma of either the major or minor salivary glands, and 96.9% had distant metastases.. Responses. Five patients (15.6%) had confirmed objective response (all partial responses) and an additional 24 patients (75.0%) had stable disease. Median progression-free ...
Background: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG). Methods: Cases including 66 PA (35 FNA, 31 resections), 12 BCA (5 FNA, 7 resections), 42 ACC (11 FNA, 31 resections), 1 BCAC FNA, and 10 NNSG (5 FNA, 5 resections) were obtained and stained for LEF-1. Results: On cell block (CB), 51% of PA and 60% of BCA were LEF-1 positive while 91% of ACC were LEF-1 negative. Among resections, there was a higher percentage of LEF-1 positive PA (84%) and BCA (86%), and a higher percentage of LEF-1 negative ACC (97%). LEF-1 ...
Parotid gland Adenocarcinoma is a rare cancer, meaning it is not as well known as other forms of cancer. Without a Ribbon is an Australian organisation that provides support for individuals who suffer from rare cancers. So, we provide a designated platform for Warriors to obtain information specific to their Rare Cancer. We also provide annual opportunities for our Warriors to meet and learn from each other. If you suffer from rare cancer such as Parotid gland Adenocarcinoma we can help and support you through your journey thanks to the generous donations we receive. Click the link below to sign up and become a Warrior today ...
TY - JOUR. T1 - Immunolocalization of Epstein-Barr virus-related antigens in a case of sweat gland adenocarcinoma. T2 - Correspondence. AU - Tanese, K.. AU - Ishiko, A.. AU - Hayase, K.. AU - Yoshida, Tadashi. AU - Kishi, Kazuo. AU - Yamada, T.. PY - 2009/9. Y1 - 2009/9. KW - EBER. KW - EBNA-2. KW - Epstein-Barr virus. KW - LMP-1. KW - Sweat gland adenocarcinoma. UR - http://www.scopus.com/inward/record.url?scp=69149108539&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=69149108539&partnerID=8YFLogxK. U2 - 10.1111/j.1365-2133.2009.09319.x. DO - 10.1111/j.1365-2133.2009.09319.x. M3 - Article. C2 - 19558594. AN - SCOPUS:69149108539. VL - 161. SP - 694. EP - 697. JO - British Journal of Dermatology. JF - British Journal of Dermatology. SN - 0007-0963. IS - 3. ER - ...
Adenoid cystic carcinoma is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In a brief report published on 17 June 2013 in theJournal of Clinical Investigation, researchers led by Andrew Futreal of the Cancer Genome Project, Wellcome Trust Sanger Institute in Cambridge, United Kingdom, reported on a whole exome sequencing performed in 24 adenoid cystic carcinoma cases.. They uncovered the involvement of multiple cancer genes that are likely to be contributing to tumour development in the context of MYB activation. The data point to disruption of chromatin regulation as a major factor in adenoid cystic carcinoma development. Furthermore, the data implicate NOTCH signalling deregulation in a proportion of cases. Finally, the analysis has identified activating mutations of the receptor tyrosine kinase FGFR2 in ...
TY - JOUR. T1 - Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. AU - Carretta, Angelo. AU - Libretti, Lidia. AU - Taccagni, Gianluca. AU - Zannini, Piero. PY - 2004/12. Y1 - 2004/12. N2 - Primary pleomorphic adenomas of the respiratory tract are rare tumors. They usually originate from the bronchial glands, but may also be unrelated to the bronchial tract and be localized in the pulmonary parenchyma. These salivary-gland type neoplasms have peculiar histological and clinical features: they usually behave as low-grade malignant neoplasms, but may also have more aggressive features. The diagnostic and therapeutic approach in a patient with a pulmonary pleomorphic adenoma is described.. AB - Primary pleomorphic adenomas of the respiratory tract are rare tumors. They usually originate from the bronchial glands, but may also be unrelated to the bronchial tract and be localized in the pulmonary parenchyma. These salivary-gland type neoplasms have peculiar histological and clinical ...
Rare type of cancer Adenoid cystic carcinoma symptoms causes and treatment एक रिपोर्ट के मुताबिक, हर साल कैंसर के पांच लाख मामलों में करीब 1200 मामले अडेनाइड सिस्टिक कार्सिनोमा के होते हैं। Read latest hindi news (ताजा हिन्दी समाचार) on rare type of cancer, adenoid cystic carcinoma, adenoid cystic carcinoma symptoms - #1 हिन्दी न्यूज़ website.
Dr. Scott Laurie received his MD from the University of Ottawa in 1994, and is certified in Internal Medicine and Medical Oncology. He completed a fellowship in Thoracic Oncology at the Memorial Sloan-Kettering Cancer Center in New York in 2000, and subsequently joined on staff at the Ottawa Hospital Cancer Centre. He is an Associate Professor at the University of Ottawa. His research interests are thoracic malignancies, salivary gland malignancies, and investigational new drugs. He has been the principal investigator of several multicenter phase II and III clinical trials. He is the current disease site chair of the Investigational New Drug committee of the NCIC Clinical Trials Group and sites on the Lung Disease site executive.. ...
Primary Sjögrens syndrome (pSS) is an autoimmune disorder mainly characterized by exocrine gland injury. Costimulatory molecules play an important role in immune-regulatory networks. Although B7 family costimulatory molecules were previously discovered in human salivary gland epithelial (HSGE) cells in pSS, the effects of the B7 family member B7-H3 (CD276) have not been well elucidated. Thus, this study aimed to investigate the role and mechanism of B7-H3 in HSGE cells in pSS. The expression of B7-H3, B7-H1, PD-1 in serum, saliva and salivary gland were examined by immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA). Immunofluorescence was used to test the expression and distribution of B7-H3, AQP5 and CK-8 in salivary gland tissues. Flow cytometry, Cell Counting Kit 8 (CCK-8) and western blot (WB) were performed to research the apoptotic, proliferative and inflammatory effects of B7-H3 in primary HSGE cells and HSGE cell lines. Our results showed that the expression of PD-1, B7