Bismuth subsalicylate, sold under the brand name Pepto-Bismol, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea. It is also commonly known as pink bismuth. Bismuth subsalicylate has the empirical chemical formula of C7H5BiO4, and it is a colloidal substance obtained by hydrolysis of bismuth salicylate (Bi(C6H4(OH)CO2)3). The actual structure[clarification needed] is unknown and the formulation is only approximate. As a derivative of salicylic acid, bismuth subsalicylate displays anti-inflammatory and bactericidal action. It also acts as an antacid. There are some adverse effects. It can cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in saliva and the colon to form bismuth sulfide. Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless. Long-term use (greater than 6 weeks) may lead ...
2-Trifluoromethylbenzoic acid, 3,5-difluorophenyl ester | C14H7F5O2 | CID 530822 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
An original, highly sensitive and specific high performance liquid chromatographic method has been developed for the measurement of aspirin and salicylate in plasma. Minimum concentrations of 10 xg/L (aspirin) and 0.5 mg/L (salicylate) can be measured using 1 ml of plasma. After collection, plasma is first treated with physostigmine sulfate to inhibit enzymatic hydrolysis of aspirin to salicylate. Maximal recovery is achieved using an acid extraction into anhydrous diethyl ether with a subsequent drying-down step in an iced water bath. Aspirin and salicylate are separated by elution with a mixture of methanol, 1-butanol, orthophosphoric acid, and water on a reversed-phase octadecyl silane column at 47°C and detected at 234 nm by ultraviolet absorption. Quantitation is achieved using the peak height ratio of aspirin and salicylate to internal standard (m-anisic acid). The assay has been used for the study of simultaneous aspirin and salicylate pharmacokinetics after a single oral dose of 100 mg ...
Anyone can be, or become, sensitive to anything, including salicylates. It happens when people or over exposed or continually exposed; however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. It also tends to affect older adults or people who have worsening asthma problems, and, yet, the worsening asthma problems may be related to continual exposure to salicylates. So, its a vicious cycle as your health continues to deteriorate, and you experience more and more health problems.. If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. For more information on salicylates in food or how to conduct a test see the How Do I Get More Information?section at the bottom of this article. If you have salicylate problems and remove them from your life, your ...
Use only if your formulation does NOT contain salicylates. Pepto-Bismol® should not be used in cats since it contains salicylates, the active ingredient in aspirin. Cats are very sensitive to aspirin so it should be avoided. WARNING - PLEASE NOTE THAT THE NEW FORMULATIONS OF KAOPECTATE MAY ALSO HAVE SALICYLATES. Do not use if your formulations lists salicylates as an active ingredient. Any vomiting or diarrhea that persists for more than 24 hours needs your veterinarian's attention. ...
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Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM). Salsalate treatment increased oxygen consumption, lowered fasting glucose, improved glucose tolerance and led to an ∼55% reduction in liver lipid content; effects observed in both WT and AMPK β1KO mice. To explain these AMPK-independent effects, it was found that salicylate increases oligomycin-insensitive respiration (state 4o) and directly increases mitochondrial proton conductance at clinical concentrations. This ...
It is important to note that cats are more sensitive to toxicity with salicylates and should never be given this medication.. Signs and symptoms of toxicity: vomiting, diarrhea, melena (dark, tarry stool), abdominal pain, pale gums, altered mental status, difficulty breathing, and dehydration. While some signs may appear within several hours of ingestion, it may take several days for other signs to appear.. Toxic consumption: Do not exceed dosing recommendations from your veterinarian. Report all incidents of accidental ingestion immediately.. References ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The salicylate assay aids in the diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to insure appropriate therapy. Salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic acid (aspirin) is the most commonly used salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. For this reason, salicylates are often seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Prompt recognition and management are necessary to avoid serious consequences. ...
Bismuth by Jamp Pharma: Bismuth subsalicylate belongs to a class of medications called antacids and adsorbents. It is used to help relieve heartburn, indigestion, upset stomach, nausea, and diarrhea. How bismuth subsalicylate works is not completely understood, but it is thought to work by coating the stomach and intestines (protecting them from stomach acid), by reducing inflammation in the stomach, and by killing certain bacteria.
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Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. Early on these may be subtle while larger doses may result in fever. Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. Excess doses can be either on purpose or accidental. Small amounts of oil of wintergreen can be toxic. Diagnosis is generally based on repeated blood tests measuring aspirin levels and blood gases. While a type of graph has been created to try to assist with diagnosis, its general use is not recommended. In overdose maximum blood levels may not occur for more than 12 hours. Efforts to prevent poisoning include child-resistant packaging and a lower number of pills per package. Treatment may include ...
OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation end products (AGEs) that have been implicated in diabetic vascular complications. RESEARCH DESIGN AND METHODS Participants were from the Targeting Inflammation Using Salsalate for Type 2 Diabetes (TINSAL-T2D) study, which examined the impact of salsalate treatment on hemoglobin A1c (HbA1c) and a wide variety of other parameters. One hundred eighteen participants received salsalate, 3.5 g/day for 48 weeks, and 109 received placebo. Early glycation product levels (HbA1c and fructoselysine [measured as furosine]) and AGE levels (glyoxal and methylglyoxal hydroimidazolones [G-(1)H, MG-(1)H], carboxymethyllysine [CML], carboxyethyllysine [CEL], pentosidine) were measured in patient serum samples. RESULTS Forty-eight weeks of salsalate treatment lowered levels of HbA1c and serum furosine (P
TY - JOUR. T1 - Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. AU - Li, Geming. AU - Sha, Su Hua. AU - Zotova, Elena. AU - Arezzo, Joseph. AU - Van De Water, Thomas R.. AU - Schacht, Jochen. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Salicylate has recently been demonstrated to protect against the auditory and vestibular side effects of aminoglycoside antibiotics. Similarities in the toxic mechanisms suggest salicylate as a treatment strategy to prevent the ototoxic side effects of cisplatin (CDDP). We first tested protection of the inner ear in Wistar rats receiving a single infusion of 16 mg CDDP/kg body weight with or without treatment with 100 mg/kg salicylate (bid) for 5 days beginning one day before the CDDP infusion. Cisplatin induced a threshold shift of more than 30 dB (at 14 kHz; measured by auditory evoked brain stem response) that was significantly reduced by salicylate. We then examined the protective potential of ...
Salicylates are a group of drugs, including aspirin, that are used to relieve pain and inflammation and to reduce fever. Salicylate testing may be used to detect a high level of salicylate in the blood and help diagnose an overdose (salicylate poisoning).
... (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Methyl salicylate topical may also be used for purposes not listed in this medication guide.
Methyl Salicylate containing medications, Methyl Salicylate indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from Drugs-about.com
The interference of analgesics with ACTs (Coartem, Corsucam…) has barely been studied in clinical trials.. Aspirin (acetylsalicylic acid) is sold over the counter in Africa and appears to be the first line treatment when children or adults have fever. Chronic salicylate poisoning by overdosis is common. Many children brought to a hospital in Africa have a high load of salicylic acid in their blood. Paracetamol is also of common use.. In all children admitted to Kilifi District Hospital between July and September, 1994, who had a positive blood film for Plasmodium falciparum, and one or more of coma, prostration, or respiratory distress salicylate concentrations were measured. (English M1, et al., Lancet. 1996 347(9017):1736-7). Data were available for 143 children with initial primary diagnoses of severe malaria. 129 had detectable (,l mg/dL) salicylate. Six of these had salicylate concentrations of 20 mg/dL or higher. All six had neurological impairment and metabolic acidosis and four were, ...
To address toxicological endpoints as part of the REACH registration of Benzyl Salicylate (Target Substance) it is proposed to read-across to Cyclohexyl Salicylate, Ethylhexyl salicylate and Methyl salicylate (Source Substances). The use of read-across works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. The Target Substance and Source Substances have been characterised using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling, it can be seen that the substances share structural similarities and also mechanistic action similarities which are both general and endpoint specific. For classification and labelling purposes this indicates that the structural analogues are relatively harmless and would not be classified in accordance with Regulation (EC) No 1272/2008 (CLP). The registration substance is considered to have similar properties and is therefore not classified in accordance with CLP. ...
SALICYLIC ACID 477 Methyl Salicylate. This is also known as artificial oil of wintergreen, and is obtained by the interaction of methyl alcohol and salicylic acid. It is a colourless liquid, having a characteristic, aromatic odour and a sweetish, warm, aromatic taste. It is slightly soluble in water, and freely soluble in alcohol, ether, chloroform, glacial acetic acid or carbon bisulphide. Methyl salicylate is taken accidentally, suicidally or to procure abortion, and causes symptoms of acute gastro-intestinal irritation resembling those of poisoning by salicylic acid, followed occasionally by death. About an ounce of methyl salicylate proved fatal to an adult woman in 15 hours42 and a dose of 50 ml. of methyl salicylate caused the death of a middle aged woman hi about 11 hours.43 Doses of 10 cc. to 12 cc. of methyl salicylate have killed children.44 On the other hand, a child, aged 2 years, recovered after swallowing an ounce.45 The treatment consists in the washing out of the stomach and ...
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Definition of salicylate in the Definitions.net dictionary. Meaning of salicylate. What does salicylate mean? Information and translations of salicylate in the most comprehensive dictionary definitions resource on the web.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.. Check the label of all over-the-counter (OTC), nonprescription, and prescription medicines you now take. If any of them contain acetaminophen, aspirin, other salicylates such as bismuth subsalicylate (e.g., Pepto Bismol) or magnesium salicylate (e.g., Nuprin Backache Caplets), or salicylic acid (present in some shampoos and skin products), check with your health care professional. Using any of them together with this medicine may cause an overdose.. Do not drink alcoholic beverages while taking this medicine. Stomach problems may be more likely to occur if you drink alcoholic beverages while you are taking aspirin or ibuprofen. Also, liver damage may be more likely to occur if you drink large amounts of alcoholic beverages while you are taking acetaminophen.. If you think that you or anyone else may have taken an overdose of this ...
Summary of evidence. Traveler setting: Prevention of TD is challenging because of the ubiquitous exposures to individuals through contaminated food, water, and generally unhygienic conditions among much of the developing world. Travelers are frequently counseled on preventive risk behaviors, but despite a travelers best attention to such recommendations, evidence is lacking that such precautions have any protective effect (188). Although vaccines for many of the agents commonly associated with TD are under development, these are considered a long-term solution and might likely suffer from the lack of utilization as has been seen with most travel-associated vaccines (202, 203, 204,205, 206). Alternative primary prevention strategies such as BSS, probiotics, and antibiotics have been evaluated and are considered here.. Bismuth subsalicylate. BSS has been shown in several studies to reduce the frequency of TD when used during period of risk for 3 weeks (207, 208, 209). While the salicylate portion ...
At first glance, bismuth doesnt seem to be particularly extraordinary. Element number 83 is probably most likely encountered in the compound bismuth subsalicylate (C7H5BiO4), used in gastro-intestinal remedies such as Pepto Bismol. The pure metal is also gaining popularity as a more environmentally friendly (and much more expensive) alternative to lead in hunting ammunition. In…
Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. Hemodialysis. For chronic salicylate toxicity,
Salsalate is insoluble in acid gastric fluids (,0.1 mg/ml at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body: its half-life is about one hour. About 13% is excreted through the kidneys as a glucuronide conjugate of the parent compound, the remainder as salicylic acid and its metabolites. Thus, the amount of salicylic acid available from salsalate is about 15% less than from aspirin, when the two drugs are administered on a salicylic acid molar equivalent basis (3.6 g salsalate/5 g aspirin ...
Continuous decline in cognitive performance accompanies the natural aging process in humans, and multiple studies in both humans and animal models have indicated that this decrease in cognitive function is associated with an age-related increase in oxidative stress. Treating aging mammals with exogenous free radical scavengers has generally been shown to attenuate age-related cognitive decline and oxidative stress. I assessed the effectiveness of the superoxide dismutase/catalase mimetics EUK-189 and EUK-207 on age-related decline in cognitive function and increase in oxidative stress. C57/BL6 mice received continuous treatment via osmotic minipumps with either EUK-189 or EUK-207 for 6 months starting at 17 months of age. At the end of treatment, markers for oxidative stress were evaluated by analyzing levels of free radicals, lipid peroxidation and oxidized nucleic acids in brain tissue. In addition, cognitive performance was assessed after 3 and 6 months of treatment with fear conditioning. ...
These results indicate that pretreatment of rats with the synthetic catalytic scavenger of ROS, EUK-134, prevents oxidative stress and produces a significant degree of protection against the pathological manifestations of KA-induced seizure activity in hippocampus and piriform cortex. Although numerous studies have suggested that ROS are critically involved in excitotoxicity (see refs. 5, 30, and 31 for reviews), very few studies have demonstrated convincingly, in an in vivo excitotoxic model, a causal relationship between increased production of ROS and neuronal damage (7, 32). A clear demonstration of the crucial role of ROS in excitotoxicity should include: (i) evidence for increased production of ROS specifically in neuronal populations at risk with excitotoxicity before overt signs of neuronal damage and (ii) evidence that manipulations aimed at preventing ROS accumulation reduce neuronal damage without interfering with excitatory amino acid receptor functions. The former has been difficult ...
Buy High Purity Methyl Salicylate | Medical Grade For Sale Online In USA | Oil of Wintergreen | For Topical Pain Relief Ointments | 100ml $16.00 | Methyl Ester Of Salicylic Acid | Formula C8H8O3 | Synthetic Form | CAS 119-36-8 | Weight 152.15 | Bulk Supplier & Distributor
... Systematic (IUPAC) name 2-acetyloxy-4-(trifluoromethyl)benzoic acid Identifiers CAS number  ? ATC code B01AC18 PubChem 9458 Chemical
After an excitotoxic lesion in the postnatal cortex, glial NF-κB is consistently activated at 10 hours after injury, showing its peak at day 1.4 Therefore, when triflusal is orally administered 8 hours after the NMDA injection, it preferentially targets NF-κB induced in glial cells, as the inducible neuronal NF-κB is starting to decrease when triflusal reaches the brain. Glial NF-κB is probably induced by injury-related signals that occur in the degenerating area. They may include reactive oxygen species, produced in excitotoxically damaged cells,44 and the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α, which are expressed by neurons and glial cells in this excitotoxic lesion model, showing a peak of expression at 10 hours after injury.45 On activation, NF-κB translocates to the cell nucleus and modulates the expression of several genes implicated in the development of the glial and inflammatory responses. Target genes containing a NF-κB-binding site include the ...
Temporarily relieves minor aches and pains. IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains,...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
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Salicylates: The salts, esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
The clinical manifestations and management of all salicylate intoxications are similar. An overview of salicylate intoxication in children and adolescents will be presented here. General issues relating to the clinical management of drug intoxication
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According to the results of toxicokinetic assessment, the inhalation route is not considered further as exposure scenarios for test article do not indicate inhalative exposure to be the likely route of exposure to workers in production. However, an inhalative DNEL was derived based on the NOAEC (700 mg/m³), derived from a subacute read-across study on methyl salicylate, in which no toxic signs and no macroscopic or microscopic effects were seen following exposure to a saturated atmosphere within 28 days (7 hours exposure on 5 days/week). This NOAEC was adjusted to 1207 mg/m³taking into account molecular weight differences from ethyl salicylate to homosalate. The absorption rate from dermal route is assumed to be less than 10% and the absorption rate of oral route is considered to be 100%. Therefore, the oral NOAEL of 50 mg/kg bw/d for general toxicity of methyl salicylate derived in a 2-year carcinogenicity study is converted to an equimolar value of 86 mg/kg bw/d of homosalate and route to ...
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A Moderate Drug Interaction exists between Cardene SR and magnesium salicylate. View detailed information regarding this drug interaction.