Psoriasin (S100A7), a member of the S100 family of calcium-binding proteins, is highly expressed in high-grade ductal carcinoma in situ (DCIS) and in the benign hyper-proliferative skin disorder psoriasis. Both breast cancer and psoriasis are diseases which are characterized by hyperproliferation and a disturbed differentiation of the epithelial cells as well as a pronounced angiogenesis. The potential role of psoriasin in angiogenesis and the epithelial differentiation remain unclear.. The aim of this thesis was to investigate the cellular effects of psoriasin in angiogenesis and the differentiation processes, with special emphasis on breast cancer and psoriasis.. We found that psoriasin expression was induced in mammary epithelial cells and keratinocytes by oxidative stress. Psoriasin expression was shown to induce vascular endothelial growth factor (VEGF) expression and several other pro-angiogenic factors in epithelial cells. Upon down-regulation of psoriasin, H2O2-induced expression of VEGF ...
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal tumor-derived mammary epithelial cells has previously identified the S100A2 protein as potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however, has not been elucidated to date. Here, we report for the first time that during recovery from hydroxyurea treatment, the S100A2 protein translocated from the cytoplasm to the nucleus and co-localized with the tumor suppressor p53 in two different oral carcinoma cells (FADU and SCC-25). Co-immunoprecipitation experiments and electrophoretic mobility shift assay showed that the interaction between S100A2 and p53 is Ca(2+)-dependent. Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C ...
RNPS1 (uc002cpu.3) at chr16:2303100-2317858 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 1, mRNA. RNPS1 (uc010uwa.2) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpx.3) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpw.3) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpt.3) at chr16:2303100-2317604 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 1, mRNA. NRDE2 (uc010atp.1) at chr14:90744398-90778887 - Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA. NRDE2 (uc001xyj.2) at chr14:90744398-90798481 - Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA. NRDE2 (uc001xyi.2) at chr14:90744398-90798481 - ...
Psoriasin, a member of the S100 multigenic family, which is aberrantly expressed in a variety of human tumors, is considered as an attractive molecular target for cancer treatment. The present study aimed to characterize the role of psoriasin in gastric cancer (GC), the associated pathways through which it contributes to cancer development and progression, and the effect of psoriasin on cellular response to pre-operative chemotherapy in patients with GC. Expression of psoriasin mRNA and protein were analyzed using quantitative polymerase chain reaction and immunohistochemistry of gastric cancer cohorts, respectively. Gastric cancer cell models with differential expression of psoriasin were generated using stable cell lines that overexpressed psoriasin. The in vitro biological functions of the cells in response to psoriasin overexpression and to chemotherapeutic agents were assessed using various cell-based assays. Psoriasin was overexpressed in patients with advanced GC, and high psoriasin ...
Nuclear localization of the metastasis-associated protein S100A4 has been shown to correlate with advanced disease stage in primary colorectal carcinomas (CRC), but nuclear function and its relevance...
The Arabidopsis ABI1 locus is essential for a wide spectrum of abscisic acid (ABA) responses throughout plant development. Here, ABI1 was shown to regulate stomatal aperture in leaves and mitotic activity in root meristems. The ABI1 gene was cloned and predicted to encode a signaling protein. Although its carboxyl-terminal domain is related to serine-threonine phosphatase 2C, the ABI1 protein has a unique amino-terminal extension containing an EF hand calcium-binding site. These results suggest that the ABI1 protein is a Ca(2+)-modulated phosphatase and functions to integrate ABA and Ca2+ signals with phosphorylation-dependent response pathways. ...
Dr Torkel Klingberg and colleague Fiona McNab identified irrelevance filter in the brain that weeds out unnecessary information.
The first whole-brain map of electrical connectivity in the brain has been constructed by a research team at the University of Pennsylvania.
Recombinant human S100B Calcium-Binding Protein, Western Blot Control protein - 230-00002-WBC. Liquid . Expression system is Escherichia coli (E.coli).
References for Abcams Recombinant Human Psoriasin protein (ab125655). Please let us know if you have used this product in your publication
References for Abcams Recombinant Human S100A4 protein (ab85489). Please let us know if you have used this product in your publication
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A novel protein target of mouse calcyclin (S100A6) was detected by a gel overlay method with 125I-labelled calcyclin. Interaction of calcyclin with its 30 kDa target protein (p30) present in Ehrlich ascites tumour (EAT) cells depended on the presence of Ca2+ ions. The binding of p30, evidenced by the reaction with 125I-labelled calcyclin, was found to be of higher affinity than the binding between mouse calcyclin and annexin II or glyceraldehyde-3-phosphate dehydrogenase. Examination of tissue extracts by the gel overlay method has shown that p30 is present not only in the EAT cells but also in mouse brain and spleen. This novel target protein of mouse calcyclin was purified to homogeneity from EAT cells by means of Phenyl-Sepharose chromatography, affinity chromatography and CM-cellulose chromatography. Purified p30 was digested with α-chymotrypsin and a partial amino acid sequence of one of the resulting peptides was established. A database search analysis revealed that the sequence is ...
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We performed subtractive and differential hybridization for transcript comparison between murine fibroblasts and isogenic epithelium, and observed only a few novel intracellular genes which were relatively specific for fibroblasts. One such gene encodes a filament-associated, calcium-binding protein, fibroblast-specific protein 1 (FSP1). The promoter/enhancer region driving this gene is active in fibroblasts but not in epithelium, mesangial cells or embryonic endoderm. During development, FSP1 is first detected by in situ hybridization after day 8.5 as a postgastrulation event, and is associated with cells of mesenchymal origin or of fibroblastic phenotype. Polyclonal antiserum raised to recombinant FSP1 protein stained the cytoplasm of fibroblasts, but not epithelium. Only occasional cells stain with specific anti-FSP1 antibodies in normal parenchymal tissue. However, in kidneys fibrosing from persistent inflammation, many fibroblasts could be identified in interstitial sites of collagen ...
Various structures in the brain contain many important clues to the brain?s development and function. Among these, the microscopic organization of neural tissue is of particular interest since such organization has direct potential to affect the formation of local synaptic connectivity between axons and dendrites, serving as an important factor affecting the brain?s development. While the organization of the brain at large and intermediate scales had been well studied, the organization of neural tissue at micrometer scales remains largely unknown. In particular, at present it is not known what specific structures exist in neuropil at micrometer scales, what effect such structures have on formation of synaptic connectivity, and what processes shape the micrometer-scale organization of neuropil. In this work, we present an analysis of recent electron microscopy reconstructions of blocks of neuropil tissue from rat s. radiatum of hippocampal CA1 to provide insights into these questions. We propose ...
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Allow specimen to clot completely at room temperature. Separate serum from cells ASAP. Serum should be separated from cells immediately to avoid release of NSE from blood cells ...
In human melanoma cell lines, the calcium binding protein S100A2 augments the antiproliferative activity of interferon-alpha (IFN) by an unknown mechanism. I show by microarray profiling that recombinant over-expression of S100A2 upregulates the expression of a subset of IFNα response genes beyond the maximal cytokine inducible level including IFITM3, a gene with documented antiproliferative activity. I have chosen IFITM3 as chromosomal IFN response reporter gene in a model system consisting of two human melanoma cell lines ME15 and D10 described previously (Brem, Oraszlan-Szovik et al. 2003). In ME15 cells IFITM3 expression is strictly IFN dependent whilst it is constitutively expressed in the IFN resistant D10 cells. It was shown that S100A2 is sufficient to restore IFN sensitivity in D10 (Foser, Redwanz et al. 2006) and I show by indirect immunofluorescence cytoplasmic localization of S100A2, which eliminates a direct function as a transcriptional enhancer of IFITM3 expression ...
By Teresa Conrick A few months back, I wrote about a calcium-binding protein, S100B, as it had been implicated as a possible biomarker in Autism -- Autistic children had significantly higher serum S100B protein levels than healthy controls. From that...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Mouse anti Human S100 Protein antibody, clone 8B10 recognizes S100 protein derived from human brain tissue. It is a 21kDa acidic calcium-b
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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S100兔多克隆抗体(ab34686)可与小鼠, 大鼠, 牛, 人样本反应并经WB, ELISA, IHC实验严格验证,被5篇文献引用并得到1个独立的用户反馈。所有产品提供质保服务,中国75%以上现货。
S100兔多克隆抗体(ab76729)可与小鼠, 大鼠, 牛, 人, 猴样本反应并经IHC, ICC实验严格验证,被2篇文献引用并得到2个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
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TY - JOUR. T1 - Novel interaction of the dopamine D2 receptor and the Ca 2+ binding protein S100B. T2 - Role in D2 receptor function. AU - Liu, Yong. AU - Buck, David C.. AU - Neve, Kim A.. PY - 2008/8/1. Y1 - 2008/8/1. N2 - S100B is a calcium-binding protein with both extracellular and intracellular regulatory activities in the mammalian brain. We have identified a novel interaction between S100B and the dopamine D2 receptor. Our results also suggest that the binding of S100B to the dopamine D2 receptor enhances receptor signaling. This conclusion is based on the following observations: 1) S100B and the third cytoplasmic loop of the dopamine D 2 receptor interact in a bacterial two-hybrid system and in a poly-histidine pull-down assay; 2) immunoprecipitation of the D2 receptor also precipitates FLAG-S100B from human embryonic kidney 293 cell homogenates and endogenous S100B from rat neostriatal homogenates; 3) S100B immuno-reactivity was detected in cultured neostriatal neurons expressing the ...
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Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is unknown. We characterized the functional consequences of MTA1 overexpression in cancer cells with an emphasis on its potential role as a deacetylator of hypoxia-inducible factor-1α (HIF-1α). MTA1 increased the expression of HIF-1α protein, but did not increase the expression of its mRNA. Glutathione S-transferase pull-down and coimmunoprecipitation assays demonstrated direct interaction of MTA1 with HIF-1α both in vitro and in vivo. Immunoprecipitation and acetylation assays also showed that MTA1 has deacetylation activity on HIF-1α in vivo. Moreover, MTA1 increased the transcriptional activity of HIF-1α and enhanced the expression of vascular endothelial growth factor, a target molecule of HIF-1α. Conditioned medium collected from MTA1 transfectants also increased angiogenesis in vitro ...
Calmodulin (CaM) (an abbreviation for CALcium MODULated proteIN) is a calcium-binding protein expressed in all eukaryotic cells. It can bind to and regulate a number of different protein targets, thereby affecting many different cellular functions. Calmodulin 1 is one of nearly twenty human calmodulins.Calmodulinis the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.
Protein interactions animation. Clip 10 of 10. Final clip in an animation sequence showing protein interactions within a dividing cell. This clip, which includes labels, shows an actin-myosin bundle (right) forming part of the contractile ring at the periphery of the cell. Proteins (left) are in the surrounding cytoplasm, including those that activate the contractile ring. This contraction (a form of cytokinesis) is initiated by a wave of calcium ions (see K003/3843). Here, the heads of the myosin filaments (dark) are wrapped around the actin filaments (light) and pulling them. The full sequence of ten clips shows the interaction between the protein calmodulin (CaM, calcium-modulated protein), calcium ions, the MLCK (myosin light-chain kinase) protein, and the actin-myosin bundles of the cells cytoskeleton, resulting in contraction of the membrane and cell division. For the entire sequence, see clips K003/3847 to K003/3838. For the same sequence as an anaglyph 3D animation, see clips K003/4492 to K003
Background and methods. In the letter the authors discuss the findings in Kellerman and co-workers paper: Early CSF and Serum S 100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachoid Haemorrhage published in this journal. Among the findings reported in this paper is that an initial S 100B value of more than 0.7 μg/l would strongly indicate a very poor prognosis. This finding is discussed.. Conclusion. That a use of S 100B as a prognostic tool for clinical decision making is very doubtful and should most probably be refrained from.. ...
New Haven, Conn. The helpless behavior that is commonly linked to depression and post-traumatic stress disorder (PTSD) is preceded by stress-related losses of synapses microscopic connections betwee...
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The term S-100 protein is used to describe a family of low-molecular-weight proteins, found in vertebrates, that are 100% soluble in ammonium sulfate at neutral pH. Over 20 types of S-100 proteins are known at present. S-100 proteins all have calcium-binding sites and a helix-loop-helix (HLH) domain. They are usually found in Schwann cells, melanocytes, and glial cells. S-100 proteins are involved in a wide range of functions, from regulation of calcium homeostasis to the inflammatory response. Some S-100 proteins are markers for certain types of cancer, as well as inflammatory diseases.. ...
The term S-100 protein is used to describe a family of low-molecular-weight proteins, found in vertebrates, that are 100% soluble in ammonium sulfate at neutral pH. Over 20 types of S-100 proteins are known at present. S-100 proteins all have calcium-binding sites and a helix-loop-helix (HLH) domain. They are usually found in Schwann cells, melanocytes, and glial cells. S-100 proteins are involved in a wide range of functions, from regulation of calcium homeostasis to the inflammatory response. Some S-100 proteins are markers for certain types of cancer, as well as inflammatory diseases.. ...
This is the authors final draft of the version published as FEBS Letters, 2008, 582, (2008), pp.1651-1656. The online version can also be accessed via http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-4SBHBHT-C&_user=123215&_coverDate=05%2F28%2F2008&_rdoc=4&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234938%232008%23994179987%23690098%23FLA%23display%23Volume)&_cdi=4938&_sort=d&_docanchor=&_ct=26&_acct=C000010181&_version=1&_urlVersion=0&_userid=123215&md5= ...
In addition to finding most of the known EJC factors splicing containing variable 5 exon (v5 meoitic and mitotic paragene T codon B cell) and correlates scaffold hnRPN-I/U, with SRM160 is the more important component of the complex; it has multiple R, S, and P residues. The acinus L, S, and S-prime cDNAs contain open reading frames (ORF) read anticlockwse-L, and clockwise-R to an abundance of unspecific YWHAG from HPRD-[§§], overexpressed amino acid residues near the exon-exon junctions of mRNAs. While a stable association of development and differentiation and ACN1 condensation such as polymerase eta ribonucleoprotein U scaffold attachment after irradiation with UVC light but another protein inhibitor is replication-independent damage accumulation of residues is not necessary for UV-induced polymerase eta focus formation. Where as RNA binding protein S1, intronless [wild type] versions of SRm160 is normally also dependent on U1-2 (igG) certain non-T/non-B-ALL, cells. Small nuclear RNPs an ...
Fimbrins are EF-hand calcium-binding proteins that actively participate in binding to and bundling of actin. In actin filaments, one molecule of fimbrin might
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Question posted in: psoriasin, psoriasis, pharmacy, stelara - Additional details: ... first shot I was almost completely clear of all psoriasis and ...
Introduction: S100A1 is a member of the S100 family of calcium-binding proteins. S100A1 controls Ca2+ dynamics in cardiomyocytes and plays an important role in heart failure. S100A1 is also strongly expressed in mouse platelets, but its role in platelet biology has not been investigated.. Goal: To determine the role of S100A1 in platelet activation and thrombosis.. Methods and Results: Platelet activation in response to threshold levels of convulxin, a specific agonist for the collagen receptor GPVI, showed significantly increased activation of αIIbβ3 integrin and α-granule release in S100A1-deficient (SKO) platelets compared with wild-type (WT) platelets. Consistently, SKO platelets also showed a more robust aggregation response to convulxin and collagen. In contrast, SKO platelets responded normally to stimulation with PAR4 receptor-activating peptide or ADP. Adhesion of SKO platelets to collagen under flow conditions was not significantly different to that of WT platelets. However, we ...
We have recently shown that the co-expression and interaction of the receptor for advanced glycation end products (RAGE) and its ligand S100B post myocardial infarction play a role in myocyte apoptosis. In other cell types, the S100B/RAGE interaction triggers signaling pathways including NF-kB activation and translocation, MAP kinases, and p53. To determine the signaling pathways modulated by the S100B/RAGE interaction contributing to myocyte apoptosis, rat neonatal cardiac myocyte cultures transfected with a full-length cDNA of the RAGE gene, a dominant-negative cytoplasmic deletion mutant of RAGE, or vector control were treated with nanomolar (1-1000) concentrations of recombinant bovine brain S100B for 48 hrs. 1 μM S100B induced vector alone-transfected myocyte apoptosis, as evidenced by increased terminal deoxynucleotidyltransferase-mediated UTP end labeling (TUNEL) [12.4±0.7% vs. 5.6±0.3% (untreated) of total cells p,0.05], DNA fragmentation, cytochrome C release from the mytochondria to ...
TY - JOUR. T1 - The pericentriolar lattice of PtK2 cells exhibits temperature and calcium-modulated behavior. AU - Baron, Andre T.. AU - Suman, Vera J.. AU - Nemeth, Edward. AU - Salisbury, Jeffrey L.. PY - 1994/11/1. Y1 - 1994/11/1. N2 - In this study, we demonstrate that manipulations of temperature and free calcium alter the morphology of the centrin-containing pericentriolar lattice of PtK2 cells. Immunofluorescence microscopy reveals that low-temperature incubation (4°C) causes anti-centrin-labeled pericentrosomal spots to coalesce in the peripheral cytoplasm, and fuses small spots into larger spots near the cell center. At electron microscopic resolution, well-formed pericentriolar satellites appear around the centrioles in response to incubation at 4°C. Elevated free calcium enhances these low-temperature-dependent effects. The data suggest that pericentrosomal spots correspond to one or more pericentriolar satellites, and that pericentriolar satellites and centrosomal matrix are ...
Why is there a warning about this product containing chemicals known to the State of California to cause cancer? This warning refers to coal tar, the active ingredient in PSORIASIN Ointment, and is a requirement of the State of California; however an expert advisory panel of the US FDA has recognized the active ingredient in PSORIASIN Ointment to be safe and effective when used as directed. The FDA does not share the opinion of the State of California that this warning should be present ...
All studies were under 200 patients in size and most were under 100 patients. The studies find sensitivities from 27% 95% and specificities from 70% to 97%. The reasons for this great variation in findings may in large part be due to the small sample sizes. The specificities seem to perform better than the sensitivities and thus the finding of a high S-100 may indicate that your patient is at high risk of long term disability. The cut-points for a significant S-100 level differ between studies also and are generally much higher when applied to patients after a severe head injury. Most studies agree that S-100 levels must be taken within 6 hours of head injury ...