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Cardiovascular Psychiatry and Neurology is a peer-reviewed, Open Access journal that publishes original pre-clinical/basic and clinical research on biological mechanisms of and treatments for co-occurring cardiovascular disorders and disorders of the central nervous system, including alterations in behavior, emotion, and cognition.
The above described objects, features and advantages of the present invention will become more apparent from the description of the appended claims.. Fig. 1A is a view showing the appearance of a measuring device according to an embodiment of the present invention, and Fig. 1B is a side view showing the measuring device in Fig. 1A. Referring to Figures 1A and 1B, the measuring device 1 includes an external sub-device from the appearance. 2. The housing 10, the sensor 11, the electrodes 12-13, the display 15, the port 16, the power switch 17, and the endless belt 18 (not shown in Figure 1B). The housing 10 is disposed on the endless belt 18. The housing 10 has an inner side and an outer side. When the equivalent measuring device 1 is placed on a specific part of the subject 19 (for example, a limb such as a wrist or a lower leg) to measure a physiological signal, the measuring device can be attached to a specific part of the subject through the annulus 18, The inner side of the housing 10 is a ...
By Teresa Conrick A few months back, I wrote about a calcium-binding protein, S100B, as it had been implicated as a possible biomarker in Autism -- Autistic children had significantly higher serum S100B protein levels than healthy controls. From that...
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Although intuitively approach b might seem best (since it is based on actual data), in reality there is little to recommend this more complex approach over the other two, as it is often possible for experienced powermeter users to estimate their TSS just as, if not more, accurately without ever knowing their heart rate. Moreover, any error introduced into the calculation of CTL, etc., as a result of poorly estimating the true TSS for one or two missing workouts is likely to be minimal. On the other hand, if a large amount of data are missing (e.g., ,10% of all files for a particular block of time), then the output of the Performance Manager calculations during and following that period should interpreted with considerable caution. In turn, this emphasizes the importance of racing with a powermeter, since individuals often incorporate frequent racing into their training program when attempting to peak.. 3) Related to the above, the long time constant for CTL means that data must be collected for ...
I looked at the link in the Smarter Balanced Assessment publication. Ill call the top figure in your post Figure 1 and the bottom Figure 2. Figure 2 from page five of the publication is described as the old-fashioned assessment where B is the right answer. Figure one is the new deeper assessment where the right answer is A yes, B no, C yes, D no. Partial Credit for YNNN, YYNN, YYYN. It makes no sense to me because without a ruler one is clearly led to estimate that B might be 2/5. ...
Background and methods. In the letter the authors discuss the findings in Kellerman and co-workers paper: Early CSF and Serum S 100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachoid Haemorrhage published in this journal. Among the findings reported in this paper is that an initial S 100B value of more than 0.7 μg/l would strongly indicate a very poor prognosis. This finding is discussed.. Conclusion. That a use of S 100B as a prognostic tool for clinical decision making is very doubtful and should most probably be refrained from.. ...
Principal Investigator:TATSUNO Yoshitsugu, Project Period (FY):1995 - 1996, Research Category:Grant-in-Aid for Scientific Research (A), Section:試験, Research Field:Legal medicine
The main result of the present study is that a single measurement of the S100B serum concentration obtained within 12 to 24 hours after symptom onset can predict a malignant course of infarction in patients with proximal MCA occlusion with a high degree of diagnostic accuracy.. It is well known from previous studies that serum S100B values increase in ischemic stroke, reaching maximum levels 2 to 4 days after onset.12,13 Furthermore, infarct size was shown to be a major determinant of both the initial slope of the S100B kinetic and the absolute S100B peak value.14,15 Our findings fit well within this context (Figure 1). We found low S100B concentrations at hospital admission and 8 hours after symptom onset. Starting with the 12-hour S100B value, patients who later developed malignant infarction showed significantly higher S100B values compared with those with a nonmalignant course. This difference further increased within the following hours and was greatest for the 24-hour value (Figure 1), ...
All studies were under 200 patients in size and most were under 100 patients. The studies find sensitivities from 27% 95% and specificities from 70% to 97%. The reasons for this great variation in findings may in large part be due to the small sample sizes. The specificities seem to perform better than the sensitivities and thus the finding of a high S-100 may indicate that your patient is at high risk of long term disability. The cut-points for a significant S-100 level differ between studies also and are generally much higher when applied to patients after a severe head injury. Most studies agree that S-100 levels must be taken within 6 hours of head injury ...
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Abstract- Accurate calibrations of multi-hole Pitot tubes require thousands of measurements spanning ranges of the fluid s velocity, and the pitch and yaw...
There are no specific protocols for Recombinant human S100 alpha protein (ab68609). Please download our general protocols booklet
References for Abcams Recombinant Human S100 alpha 2 protein (ab104821). Please let us know if you have used this product in your publication
Our recent studies on rat pituitary tissue suggest that the annexin 1 (ANXA1)-dependent inhibitory actions of glucocorticoids on ACTH secretion are effected via a paracrine mechanism that involves protein kinase C (PKC)-dependent translocation of a serine-phosphorylated species of ANXA1 (Ser-P-ANXA1) to the plasma membrane of the nonsecretory folliculostellate cells. In the present study, we have used a human folliculostellate cell line (PDFS) to explore the signaling mechanisms that cause the translocation of Ser-P-ANXA1 to the membrane together with Western blot analysis and flow cytometry to detect the phosphorylated protein. Exposure of PDFS cells to dexamethasone caused time-dependent increases in the expression of ANXA1 mRNA and protein, which were first detected within 2 h of steroid contact. This genomic response was preceded by the appearance within 30 min of substantially increased amounts of Ser-P-ANXA1 and by translocation of the phosphorylated protein to the cell surface. The prompt
Background: Schizophrenia can be conceptualized as a form of dysconnectivity between brain regions. To investigate the neurobiological foundation of dysconnectivity, one approach is to analyze white matter structures, such as the pathology of fiber tracks. S100B is considered a marker protein for glial cells, in particular oligodendrocytes and astroglia, that passes the blood brain barrier and is detectable in peripheral blood. Earlier Studies have consistently reported increased S100B levels in schizophrenia. In this study, we aim to investigate associations between S100B and structural white matter abnormalities.Methods: We analyzed data of 17 unmedicated schizophrenic patients (first and recurrent episode) and 22 controls. We used voxel based morphometry (VBM) to detect group differences of white matter structures as obtained from T1-weighted MR-images and considered S100B serum levels as a regressor in an age-corrected interaction analysis. Results: S100B was increased in both patient subgroups.
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RNPS1 (uc002cpu.3) at chr16:2303100-2317858 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 1, mRNA. RNPS1 (uc010uwa.2) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpx.3) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpw.3) at chr16:2303100-2318413 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 2, mRNA. RNPS1 (uc002cpt.3) at chr16:2303100-2317604 - Homo sapiens RNA binding protein S1, serine-rich domain (RNPS1), transcript variant 1, mRNA. NRDE2 (uc010atp.1) at chr14:90744398-90778887 - Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA. NRDE2 (uc001xyj.2) at chr14:90744398-90798481 - Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA. NRDE2 (uc001xyi.2) at chr14:90744398-90798481 - ...
TY - JOUR. T1 - The pericentriolar lattice of PtK2 cells exhibits temperature and calcium-modulated behavior. AU - Baron, Andre T.. AU - Suman, Vera J.. AU - Nemeth, Edward. AU - Salisbury, Jeffrey L.. PY - 1994/11/1. Y1 - 1994/11/1. N2 - In this study, we demonstrate that manipulations of temperature and free calcium alter the morphology of the centrin-containing pericentriolar lattice of PtK2 cells. Immunofluorescence microscopy reveals that low-temperature incubation (4°C) causes anti-centrin-labeled pericentrosomal spots to coalesce in the peripheral cytoplasm, and fuses small spots into larger spots near the cell center. At electron microscopic resolution, well-formed pericentriolar satellites appear around the centrioles in response to incubation at 4°C. Elevated free calcium enhances these low-temperature-dependent effects. The data suggest that pericentrosomal spots correspond to one or more pericentriolar satellites, and that pericentriolar satellites and centrosomal matrix are ...
To evaluate the clinical usefulness of serum S100A12 and sRAGE, we studied these factors in patients with AOSD and compared them with those of HC. Moreover, we also studied these levels as a biomarker for checking disease activity. To the best of our knowledge, the present study is the first to show elevated S100A12 levels with low concentration of circulating sRAGE in patients with AOSD. Further, serum S100A12 correlated with several inflammatory markers and systemic score, and serum S100A12 was decreased when the disease activity resolved in the followup patients with AOSD.. The activities of S100A12 include chemotactic activity and activation of intracellular signaling cascades leading to cytokine production and induction of oxidative stress36. S100A12 is overexpressed in several inflammatory diseases, such as inflammatory bowel diseases, vasculitis, JIA, rheumatoid and psoriatic arthritis, and asthma8,9,17,18,19,29,37,38. Additionally, S100A12 distinguished systemic onset JIA from infections ...
Three enolase isozymes are known in mammals, each with a characteristic tissue distribution: alpha, beta, and gamma enolase. The ENO2 gene encodes enolase 2 (gamma, neuronal) and is expressed in mature neurons and cells of neuronal origin. It is also known as neural enolase, neuron-specific enolase (NSE), 2-phospho-D-glycerate hydrolyase, gamma-enolase, neuron-specific gamma enolase, and enolase 2. NSE exhibits neurotrophic and neuroprotective properties in central nervous system (CNS) neurons. The calcium-regulated binding of NSE to cultured neocortical neurons promotes cell survival. NSE was detected in small-cell carcinomas of neuroendocrine origin, and has been proposed as a marker for lung cancer patients.. ...
Three enolase isozymes are known in mammals, each with a characteristic tissue distribution: alpha, beta, and gamma enolase. The ENO2 gene encodes enolase 2 (gamma, neuronal) and is expressed in mature neurons and cells of neuronal origin. It is also known as neural enolase, neuron-specific enolase (NSE), 2-phospho-D-glycerate hydrolyase, gamma-enolase, neuron-specific gamma enolase, and enolase 2. NSE exhibits neurotrophic and neuroprotective properties in central nervous system (CNS) neurons. The calcium-regulated binding of NSE to cultured neocortical neurons promotes cell survival. NSE was detected in small-cell carcinomas of neuroendocrine origin, and has been proposed as a marker for lung cancer patients.. ...
Stage III melanoma includes cancers of any thickness with tumor spread to regional lymph nodes with the extent of tumor determining the best treatment.
Allow specimen to clot completely at room temperature. Separate serum from cells ASAP. Serum should be separated from cells immediately to avoid release of NSE from blood cells ...
Impairment of GABA release due to reduction of VGAT in μ3B−/−ΔNeo mice. (A and B) Measurement of glutamate (A) and GABA (B) release was performed as descr
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Lets look to the conditions of morally wrongful assistance first. Here, I must admit, Ive hit upon a snag. Although conditions (i) and (iii) seem relatively straightforward, condition (ii) seems less so. The problem has to do with the ambiguity of Tooleys original formulation of premise (7). Whereas I try to make it clear who is being referred to by introducing the characters A and B, Tooley does not and refers simply to "the person". Unfortunately, this makes it unclear whose interests are being referred to in condition (ii). Ive interpreted it above as referring As interests ( i.e. the interests of the assister) and I think this makes sense: it would seem imprudent (and likely a condition of wrongness) for A to assist another in undermining his interests. That said, it could be that Tooley is referring to Bs interests and drawing a distinction between objective and subject interests. In other words, the idea is that while B might subjectively think that a particular action (in this case ...
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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Immature. Read my post: BPMS Next Generation: IBPMS and you will understand. It is a market that from time to time a new Use Case shakes the market. This time it was Intelligent Business Operation (IBO). Software AG was one of the Vendors, which were moved from Gartner Magic Quadrant Leaders Square (BPMS Magic Quadrant) to the Visionary Square in the IBPMS Magic Quadrant. Software AG was not alone: only three Vendors appear in the Leaders Square of IBPMS. Previous Use Cases added and changed vendors position, were Case Management and Human Processes. ...
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Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal tumor-derived mammary epithelial cells has previously identified the S100A2 protein as potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however, has not been elucidated to date. Here, we report for the first time that during recovery from hydroxyurea treatment, the S100A2 protein translocated from the cytoplasm to the nucleus and co-localized with the tumor suppressor p53 in two different oral carcinoma cells (FADU and SCC-25). Co-immunoprecipitation experiments and electrophoretic mobility shift assay showed that the interaction between S100A2 and p53 is Ca(2+)-dependent. Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C ...
Standard surgical treatment for patients with stage III melanoma is removal of the primary cancer with up to 2-centimeter (over an inch) margins of the adjacent skin, depending on the thickness of the primary tumor, and removal of all of the regional lymph nodes. Outcomes of patients with stage III melanoma relate primarily to the…
It is important to understand if your Stage III melanoma has been completely removed with surgery (resected Stage III) or not (unresectable Stage III).
Donor Horse Serum (DHS) is derived from healthy, live animals greater than 12 months of age. The donor animals receive regular veterinary inspection and care, and are kept in carefully managed and strictly segregated herds. The donor animals are all gelded draft horses in order to limit lot-to-lot hormone level variations A variety of cell types can be successfully propagated in DHS. It is frequently used in combination with bovine sera or independently to supplement media for mammalian cell culture. DHS is often utilized in bovine virus research applications since it does not contain bovine antibodies. It is also used as a supplement in some bacteriological media. Donor Horse Serum, Heat Inactivated is treated by heat inactivation where serum is exposed to a temperature of 56 °C for 30 minutes under controlled conditions. Learn more.
Particularly interesting are explanations of the Better-Than-Average Effect that appeal to peoples idiosyncratic standards. What constitutes skillful driving? Person A might think that the best standard of driving skill is getting there quickly and assertively, while still being safe, while Person B might think skillful driving is more a matter of being calm, predictable, and within the law. Each person might then prefer the standard that best reflects their own manner of driving, and in that way justify viewing themselves as above average (e.g., Dunning et al. 1991; Chambers and Windschitl 2004).. In some cases, this seems likely to be just typical self-enhancement bias: Because you want to think well of yourself, in cases where the standards are ambiguous, you choose the standards that make you look good. Changing example, if you want to think of yourself as intelligent and youre good at math, you might choose to think of mathematical skill as central to intelligence, while if youre good at ...
Recombinant human S100B Calcium-Binding Protein, Western Blot Control protein - 230-00002-WBC. Liquid . Expression system is Escherichia coli (E.coli).
Richet je bil sin zdravnika in je prav tako šel študirati medicino na pariško univerzo, leta 1877 pa je tam diplomiral. Deset let pozneje je bil imenovan za profesorja fiziologije. Sprva je raziskoval različne stvari na področju fiziologije, kot npr. nevrokemijo, prebavo, termoregulacijo v homeotermnih živalih in dihanje. Leta 1898 je postal član Nacionalne akademije za medicino (fr. Académie Nationale de Médecine). Leta 1878 je Richet dobil idejo za izdelavo imunizacijskega seruma: če bi vbrizgal živali določeno snov (antigen), bi v njeni krvi nastala protitelesa. Slednja bi varovala pred patogenimi bakterijami ali bakterijskimi strupi. Serum s protitelesi bi tako lahko človeku podelil imunost proti določeni bolezni. Richet je tako hotel napraviti imuni serum za tuberkulozo, vendar se mu to ni posrečilo. Svoje delo je kljub temu nadaljebval in konec 19. stoletja ugotovil, da žival včasih pade v smrtni šok, če dobi še drugo dozo antigena. Ta poseben imunski odziv je Richet ...
|b||i|Background/Aims:|/i||/b| Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly d
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okay, Im not this pregnant, but somebody make me this cake, pleeeeaaase!). My beta level came in at 251. Now I will confess that I know nothing about beta levels or what they could imply, except that the higher the beta, the more "sure" the pregnancy is at this point. I tried to look up some information on it, but there seems to be a rather large range in numbers, so Im just happy that were pregnant, "very pregnant" to use the words of my clinic coordinator. I will have another test for beta levels on Thursday and Monday; we definitely want to see those numbers rising rapidly. Our first ultrasound will be Sept. 13 to confirm a heartbeat. Fortunately, I am not experiencing any symptoms yet, but it is rather early. I can however tell you that the moodiness of the progesterone will not lay off, even for a second. And my poor hubby gets the brunt of it all. Im so thankful for a passive and forgiving husband in this....even when I asked him to leave the hotel room because his mere presence was ...
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Rika Susanti. Blunt brain injury is the highest cause of death in crime. Many efforts to determining cause of death, besides autopsy, have been done. CKBB, NSE, and S100B levels is some of biomarkers that found in human getting blunt brain injury. Alternative of determining cause of death, besides autopsy, is focused to these biomarkers. Studys purpose is to analyze CKBB, NSE, and S100B levels in cerebrospinal fluid and serum to determining cause of death and time of death. Moreover, this study describes about histopathology description of brain tissue.. This is experimental study with post test only group design, comparing handling of death caused because of blunt brain injury to ketamine acute poisoning. Total of handling groups are 8. Each group has 6 mature Rattusnovergicus Sprague Dawley. CKBB, NSE, and S100B levels were examined by sandwich ELISA after 0 hour, 1 hour, 2 hours and 3 hours post mortem. This study examined histopathologyof brain tissue usingHematoxylin Eosin staining. It ...
Ipilimumab as adjuvant therapy significantly improves overall survival in patients with high risk stage III melanoma, according to the EORTC 18071 phase III trial results presented for the first time today at the ESMO 2016 Congress in Copenhagen.
Cytosolic levels of neuron-specific enolase in squamous cell carcinomas of the lung. - A Ruibal, M I Nuñez, J Rodríguez, L Jiménez, M C del Rio, J Zapatero
The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) exists as several dimeric isoenzymes (αα, αβ, αγ, ββ and γγ) composed of three distinct subunits α, β and γ. The γ-unit is found either in a homologous γγ- or in a heterologous α, γ-isoenzyme and is known as neuron-specific enolase (NSE). The monoclonal antibodies used in the CanAg NSE EIA bind to the γ-subunit of the enzyme and thereby detects both the γγ- and the αγ-forms (1, 2). The NSE levels are low in healthy subjects and subjects with benign diseases. Elevated levels are commonly found in patients with malignant tumours with neuroendocrine differentiation, especially small cell lung cancer (SCLC) (3) and neuroblastoma (4 ...
Most sepsis-associated deaths in US acute care hospitals are unlikely to be preventable through better hospital-based care, a new study suggests. The cohort study reviewed the medical records of 568 patients (50.9% men, mean age 70.5 years) who were admitted to 6 hospitals and died in the hospital or were discharged to hospice and not readmitted. Researchers found:
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