It is difficult to distinguish between restrictive cardiomyopathy and constrictive pericarditis on the basis of clinical findings and simple investigation. Cardiac catheterisation has been the reference standard for diagnosis but even this does not always permit an accurate distinction. A Summagraphics digitiser and Prime 750 computer system were used to digitise the echocardiograms of 15 patients with restrictive cardiomyopathy, 10 with constrictive pericarditis and a group of 20 age and sex matched normal subjects of similar age and sex distribution. Compared with controls, patients with restrictive cardiomyopathy showed a significant reduction in the following variables (a) decreased fractional shortening, (b) decreased peak left ventricular filling and emptying rates, (c) decreased percentage posterior wall thickening, and (d) decreased peak left ventricular posterior wall thickening and thinning rates. Whereas patients with constrictive pericarditis only had significantly reduced peak left ...

A 16 year old male underwent evaluation for heart transplantation because of progressive dyspnoea, dizziness, and palpitations caused by restrictive cardiomyopathy of unknown aetiology which was unresponsive to conventional medical treatment. Idiopathic restrictive cardiomyopathy had been diagnosed at the age of less than 1 year and was associated with growth retardation, but no other overt congenital defects. During childhood and early adolescence the boy remained limited in his physical performance compared to his schoolmates. Since the autumn of 1997 progressive deterioration with dyspnoea and symptomatic arrhythmia such as atrial re-entry tachycardia or atrial flutter occurred and made further attendance of school almost impossible. Medical treatment was ineffective and, after clinical reassessment, the patient was put on the waiting list for heart transplantation in early 1998.. Echocardiographic examination at this time revealed the presence of biventricular diverticula located beneath the ...

The angiographic features of the left ventricle were examined in patients with idiopathic hypertrophic subaortic stenosis who had clinical and hemodynamic evidence of obstruction. Of 36 combined hemodynamic and angiographic studies considered to be technically satisfactory, 33 showed a characteristic combination of abnormalities. In the frontal projection in systole, a linear radiolucent area extended across the left ventricular outflow tract 2 to 2.5 cm below the aortic annulus, at a level corresponding to the site of intraventricular pressure change. In the left oblique and lateral projections, the mitral leaflets did not swing posteriorly in a normal fashion, but projected into the outflow tract during mid and late systole. The radiolucent line, seen in the frontal views, was considered to represent contact of the leading edge of the leaflet with the hypertrophied muscular interventricular septum. The jet of mitral regurgitation, when present, was seen immediately below the anterior mitral ...

Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Diabetic Eye Disease Devices Market Research Report covers the present scenario and the growth prospects of the Diabetic Eye Disease Devices Industry for 2016-2020. Diabetic Eye Disease Devices Market, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years and discussion of the key vendors effective in this market. To calculate the market size, the report considers the revenue generated from the sales of Diabetic Eye Disease Devices globally.. For further information on this report, please visit- http://www.marketreportsworld.com/10278652. The Diabetic Eye Disease Devices Market report contains a comprehensive market and vendor landscape in addition to a SWOT analysis of the key vendors. The study was conducted using an objective combination of primary and secondary information including inputs ...

Takotsubo cardiomyopathy is a type of non-ischemic cardiomyopathy where there is unexpected temporary still left ventricular dysfunction. Apical ballooning symptoms, MCF2 Complete heart stop, Short lived pacemaker implantation, Long lasting pacemaker implantation 1.?Launch Takotsubo cardiomyopathy (TC), referred to as apical ballooning symptoms also, stress-induced cardiomyopathy and broken center symptoms is a kind of non-ischemic cardiomyopathy where there is certainly sudden temporary still left ventricular (LV) dysfunction following acute emotional tension or acute medical disease. You can find six reported situations of atrioventricular stop reported along with tension cardiomyopathy which one case was noted to have slim QRS get away, three cases got wide QRS get away rhythm and for just two sufferers the nature get away rhythm isn't clear. The precise association between AV TC and block isn't clear. We present a complete case of takotsubo cardiomyopathy with complete center stop presented ...

Comment from Dr. Jennifer Johnson (Pittsburgh, PA), Section Editor of Pediatric Cardiology Journal Watch: This is a single center retrospective chart review of all pediatric hypertrophic cardiomyopathy patients who underwent exercise stress echocardiography to determine if exercise stress echocardiography can be useful in risk stratifying hypertrophic cardiomyopathy subgroups and if LVOT obstruction occurs in the patients with nonobstructive hypertrophic cardiomyopathy.. Methods: Data was collected on all pediatric hypertrophic cardiomyopathy patient who underwent exercise stress echocardiography from 2007-2018 at Boston Children's Hospital. Subjects were assigned to one of three categories based on left ventricular outflow tract gradients: group 1: ,30 mm Hg at rest and exercise; group 2: ,30 mm Hg at rest and ≥30 mm Hg with exercise; and group 3: ≥ 30 mm Hg at rest and exercise. The composite adverse endpoints on follow-up included heart transplant, aborted cardiac arrest, and sudden ...

Figure 3. Delayed contrast enhancement short axis.. Conclusion: The CMR findings confirm, on one hand, the clinical suspicion of apical hypertrophic cardiomyopathy, by showing asymmetrically increased myocardial wall thickness of the apical region, with evidence of intramyocardial fibrosis of the hypertrophied segment. On the other hand, the study also shows the coexistence of a second pattern of DCE, characteristic, in this case, of endomyocardial fibrosis, involving both, the right and left ventricular apical regions.. Perspective: Idiopathic hypereosinophilic syndrome (HES) is rare and frequently involves the heart with development of endomyocardial fibrosis, a characteristic restrictive cardiomyopathy with uni- or biventricular endocardial fibrous tissue proliferation, preferably in the apical region and inflow tract, which leads to diastolic dysfunction and, not infrequently, to embolic phenomena arising from an overlying intracavitary thrombus.(1) Although the diagnosis was initially ...

Increased production of free radicals and depletion of antioxidants are commonly observed in diabetic patients. Based on animal studies, increased production of free radicals tends to persist even after blood glucose is tightly controlled. The rationale of using a potent antioxidant is based on the observation that increased oxidative stress associated with hyperglycemia can contribute to cellular injury leading to apoptosis; consequently, leading to diabetic retinopathy. Evidence from animal model showed that alpha lipoic acid (a potent antioxidant) was effective for decreasing the progression of diabetic retinopathy and in reducing free radicals.. Therefore, we hypothesize that therapy that can exert a powerful antioxidant activity can provide a therapeutic modality needed to target the pathogenesis of diabetic retinopathy.. This study will be a 12-month pilot study demonstrating the role of alpha lipoic acid in patients who have moderate non-proliferative diabetic retinopathy.. Eligible ...

A 17-year-old, 1-kg, colony-housed, male squirrel monkey (Saimiri sciureus) developed clinical signs of congestive heart failure. The monkey presented with lethargy, increased heart and respiratory rates, and mild abdominal distention. The clinical history, laboratory analysis, and radiographic findings were consistent with heart failure due to dilative cardiomyopathy. Gross and microscopic examination of the heart confirmed a dilative cardiomyopathy. This is the first report describing congestive heart failure caused by dilative cardiomyopathy in a squirrel monkey. Spontaneous dilative cardiomyopathy may be infrequently observed in the squirrel monkeys because they are not routinely housed in the research environment during their advancing years ...

Speckle tracking echocardiography (STE) has gained importance in the evaluation of adult inherited cardiomyopathies, but its utility in children is not well characterized. We conducted a systematic review to evaluate the role of STE in pediatric inherited cardiomyopathies. PubMed, EMBASE, Web of Science, Scopus, CENTRAL and CINAHL databases were searched up to May 2020, for terms related to inherited cardiomyopathies and STE. Included were dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), left ventricular non-compaction (LVNC) and arrhythmogenic cardiomyopathy (ACM). A total of 14 cohorts were identified, of which six were in DCM, four in HCM, three in LVNC and one in ACM. The most commonly reported STE measurements were left ventricular longitudinal strain (Sl), circumferential strain (Sc), radial strain (Sr) and rotation/torsion/twist. Sl, Sc and were abnormal in all DCM and LVNC cohorts, but not in all HCM. Apical rotation and twist/torsion were increased in HCM, and decreased ...

We acknowledge and thank Dr Fukamachi and colleagues for their comments regarding our report describing the immediate effects of partial left ventriculectomy (PLV) on cardiac performance in a group of 8 patients with severe heart failure.R1 This study used pressure-area relations by echocardiographic automated border detection as a surrogate for pressure-volume relations to assess ventricular function in a predominately load-independent manner. Estimates of end-systolic elastance (Ees) and preload recruitable stroke work demonstrated variable immediate results of PLV. Changes in Ees and preload recruitable stroke work were inversely correlated with semiquantitative histological measures of myocardial fibrosis and directly related to degrees of hypertrophy.. Although Fukamachi et al raise some interesting points regarding the analysis of Ees from our data, they did not account for the fact that we used cross-sectional area as a surrogate for ventricular volume to estimate ventricular performance. ...

Purpose: : To determine the effect of panretinal photocoagulation (PRP) on the pulsatile ocular blood flow (POBF) and the pulse amplitude (PA) in patients with proliferative diabetic retinopathy (PDR). Methods: : Twelve eyes of 12 patients with PDR who had undergone PRP were included. The POBF and the PA were measured with Langham OBF computerized tonometry system before, 1 month and 6 month after the last photocoagulation. Results: : The mean POBF and PA significantly (p,0.05) decreased 1 month (589.8 +/- 74.1 microlit/min and 1.26 +/- 0.23 mmHg) and 6 months (563.39 +/- 51.7 microlit/min and 1.08 +/- 0.10 mmHg) after PRP compared with those (770.2 +/- 90.2 microlit /min and 1.61 +/- 0.24 mmHg) before PRP. Conclusions: : This is the first study to examine the effect of PRP on pulsatile ocular blood flow using the Langham tonometer in patients with PDR. The present results that the mean PA and POBF decrease after PRP indicate that total choroidal blood flow may decrease in response to PRP. ...

TY - JOUR. T1 - Histopathological correlation of ablation lesions guided by noncontact mapping in a patient with peripartum cardiomyopathy and ventricular tachycardia. AU - Palma, Eugen C.. AU - Saxenberg, Victoria. AU - Vijayaraman, Pugazhendhi. AU - Ferrick, Kevin J.. AU - Gross, Jay N.. AU - Kim, Soo G.. AU - Fisher, John D.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - A patient with peripartum cardiomyopathy developed a nearly incessant nonsustained VT. Guided by a noncontact mapping system, the tachycardia was mapped to the mid-septum of the right ventricle and ablated. Despite transient success, the tachycardia recurred and the patient subsequently died of multiorgan failure. Histopathological correlation of the ablation site revealed a nontransmural lesion that may have contributed to the failure of the ablation.. AB - A patient with peripartum cardiomyopathy developed a nearly incessant nonsustained VT. Guided by a noncontact mapping system, the tachycardia was mapped to the mid-septum of the ...

Diabetic cardiomyopathy is a disorder of the heart muscle in people with diabetes. It can lead to inability of the heart to circulate blood through the body effectively, a state known as heart failure, with accumulation of fluid in the lungs (pulmonary edema) or legs (peripheral edema). Most heart failure in people with diabetes results from coronary artery disease, and diabetic cardiomyopathy is only said to exist if there is no coronary artery disease to explain the heart muscle disorder. One particularity of diabetic cardiomyopathy is the long latent phase, during which the disease progresses but is completely asymptomatic. In most cases, diabetic cardiomyopathy is detected with concomitant hypertension or coronary artery disease. One of the earliest signs is mild left ventricular diastolic dysfunction with little effect on ventricular filling. Also, the diabetic patient may show subtle signs of diabetic cardiomyopathy related to decreased left ventricular compliance or left ventricular ...

TY - JOUR. T1 - Cardiac sarcoidosis masquerading as right ventricular dysplasia. AU - Ott, Peter -. AU - Marcus, Frank I.. AU - Sobonya, Richard E. AU - Morady, Fred. AU - Knight, Bradley P.. AU - Fuenzalida, Charles E.. PY - 2003/7/1. Y1 - 2003/7/1. N2 - Patients with cardiac sarcoidosis may present with clinical and morphological features similar to arrhythmogenic right ventricular dysplasia (ARVD) or cardiomyopathy (ARVC). Three cases of cardiac sarcoidosis are presented that clinically mimicked ARVD or ARVC until a pathology diagnosis of sarcoidosis was made at biopsy or autopsy. A diagnostic distinction, while often difficult to make, is important since treatment with corticosteroids may benefit those with sarcoidosis but is not expected to be useful in cases with ARVD or ARVC.. AB - Patients with cardiac sarcoidosis may present with clinical and morphological features similar to arrhythmogenic right ventricular dysplasia (ARVD) or cardiomyopathy (ARVC). Three cases of cardiac sarcoidosis ...

TY - JOUR. T1 - Familial Amyloid Cardiomyopathy Due to TTR Mutations. T2 - An underground Cause of Restrictive Cardiomyopathy. AU - Ruberg, Frederick L.. AU - Judge, Daniel P.. AU - Maurer, Matthew S.. PY - 2009/6. Y1 - 2009/6. UR - http://www.scopus.com/inward/record.url?scp=65649085215&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=65649085215&partnerID=8YFLogxK. U2 - 10.1016/j.cardfail.2009.04.003. DO - 10.1016/j.cardfail.2009.04.003. M3 - Article. C2 - 19477408. AN - SCOPUS:65649085215. VL - 15. SP - 464. JO - Journal of Cardiac Failure. JF - Journal of Cardiac Failure. SN - 1071-9164. IS - 5. ER - ...

Background. Selected patients with cardiac sarcoidosis undergo heart transplantation, but outcomes may be adversely affected by recurrent cardiac sarcoidosis or progressive extra-cardiac sarcoidosis. Objectives. We present our single-center experience of patients with cardiac sarcoidosis who underwent heart transplantation.. Methods. Consecutive patients that underwent heart transplantation between 1990 and 2012 were assessed. Cardiac sarcoidosis was defined by the presence of multiple non-caseating epithelioid cell granulomata in the explanted heart. Baseline characteristics and clinical outcomes were compared with a control group without cardiac sarcoidosis that underwent heart transplantation during this period.. Results. 901 patients underwent heart transplantation during the study period, of whom 4 patients had a pre-transplant diagnosis of cardiac sarcoidosis and 8 patients had sarcoidosis identified in the explanted heart. Patients with cardiac sarcoidosis had excellent post-transplant ...

TY - JOUR. T1 - Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis. AU - Marsh,Katherine M.. AU - Ferng,Alice S.. AU - Pilikian,Tia. AU - Desai,Ankit A.. AU - Avery,Ryan. AU - Friedman,Mark. AU - Oliva,Isabel. AU - Jokerst,Clint. AU - Schipper,David. AU - Khalpey,Zain. PY - 2017/1/26. Y1 - 2017/1/26. N2 - Background: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis. Case presentation: A patient with a history of multiple cardiac surgeries presented with marked fatigue, ...

Purpose : To observe features in optical coherence tomography angiography (OCTA) in mexican patients with diabetic macular edema who were treated with anti-VEGF (bevacizumab) intravitreal injections and investigate the role OCTA in future therapies of patients with diabetic macular edema Methods : Retrospectve case series showing primary outcomes of 14 mexican patients (24 eyes) with diabetic macular edema. Patients were injected with intravitreal bevacizumab (1,25 mg/0,05 ml). OCTA (Triton, Topcon) was performed in all patients after finishing anti-VEGF therapy. The obtained scans were analyzed using AngioAnalytics software Results : A total of 14 mexican patients, 9 females (64.2 %) and 5 males (35.7%) were included. A mean FAZ in superficial capillary plexus was 0.486 mm2 ± 0.209 mm2. Mean FAZ deep capillary plexus was 0.745 mm2 ± 0.228 mm2 Conclusions : OCTA demonstrated a bigger FAZ in the deep capillary plexus compared to the superficial capillary plexus. These results are similar to ...

Kussmaul sign is a paradoxical rise in jugular venous pressure (JVP) on inspiration, or a failure in the appropriate fall of the JVP with inspiration. It can be seen in some forms of heart disease and is usually indicative of limited right ventricular filling due to right heart dysfunction. Ordinarily the JVP falls with inspiration due to reduced pressure in the expanding thoracic cavity and the increased volume afforded to right ventricular expansion during diastole. Kussmaul sign suggests impaired filling of the right ventricle due to a poorly compliant myocardium or pericardium. This impaired filling causes the increased blood flow to back up into the venous system, causing the jugular vein distension (JVD) and is seen clinically in the internal jugular veins becoming more readily visible. The differential diagnosis generally associated with Kussmaul sign is constrictive pericarditis, as well as with restrictive cardiomyopathy. With cardiac tamponade, jugular veins are distended and typically ...

Background: Diabetic cardiomyopathy is a distinct cardiac pathology and the underlying mechanisms are unknown. Elevated glycogen content has been observed in the diabetic human myocardium, first recorded 80 years ago, suggesting that despite impaired glucose uptake cardiomyocytes accumulate glycogen. Anecdotal evidence of glycogen accumulation in the diabetic myocardium has since been recorded in the literature but a systematic investigation of this paradoxical phenomenon has not been conducted. Glycogen storage diseases demonstrate that increased cardiac glycogen is associated with severe functional deficits, and therefore the observed glycogen 'excess' in diabetic hearts may be an important and novel agent of pathology in diabetic cardiomyopathy. Aim: This body of work aimed to systematically investigate the role myocardial glycogen accumulation in diabetic cardiomyopathy, with a focus on glycophagy, a glycogen-specific autophagy process. Key metabolic signaling pathways (insulin, AMPK, ...

To the Editor,. We read with great interest the article by Ismail et al1 looking at the role of late gadolinium enhancement cardiac magnetic resonance (CMR) in the risk stratification of patients with hypertrophic cardiomyopathy (HCM). We would like to congratulate the authors for delineating the interesting findings that the amount of myocardial fibrosis was a strong univariable predictor of sudden cardiac death … ...

OBJECTIVE--To compare the incidence and prognosis of subaortic stenosis associated with a ventricular septal defect and to define the morphological basis of subaortic stenosis. DESIGN--Presentation and follow up data on 202 patients with subaortic stenosis seen at the Royal Liverpool Children's Hospital between 1 January 1960 and 31 December 1991 were reviewed. Survivors were traced to assess their current clinical state. Necropsy specimens of 291 patients with lesions associated with subaortic stenosis were also examined. RESULTS--In the clinical study; 65 (32.1%) of the 202 patients with subaortic stenosis had a ventricular septal defect (excluding an atrioventricular septal defect). 32 of these patients had a short segment (fibromuscular) subaortic stenosis. 33 had subaortic stenosis produced by deviation of muscular components of the outflow tracts. In 17 patients (51.5%) this was caused by posterior deviation or extension of structures into the left ventricular outflow tract, resulting in ...

TY - JOUR. T1 - Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase. AU - Octavia, Yanti. AU - Kararigas, Georgios. AU - de Boer, Martine. AU - Chrifi, Ihsan. AU - Kietadisorn, Rinrada. AU - Swinnen, Melissa. AU - Duimel, Hans. AU - Verheyen, Fons K.. AU - Brandt, Maarten M.. AU - Fliegner, Daniela. AU - Cheng, Caroline. AU - Janssens, Stefan. AU - Duncker, Dirk J.. AU - Moens, An L.. PY - 2017/12. Y1 - 2017/12. KW - anthracycline. KW - antioxidant enzyme. KW - cardiotoxicity. KW - free radical. KW - nitric oxide. KW - LEFT-VENTRICULAR DYSFUNCTION. KW - CARDIAC DYSFUNCTION. KW - CARDIOVASCULAR-DISEASE. KW - INDUCED CARDIOTOXICITY. KW - MITOCHONDRIAL-FUNCTION. KW - PRESSURE-OVERLOAD. KW - HEART-FAILURE. KW - MORTALITY. KW - PROTECTS. KW - INJURY. U2 - 10.1111/jcmm.13231. DO - 10.1111/jcmm.13231. M3 - Article. VL - 21. SP - 3277. EP - 3287. JO - Journal of Cellular and Molecular Medicine. JF - Journal of Cellular and Molecular Medicine. SN - ...

Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease) - Pipeline Review, H1 2014. Summary. Global Markets Direct s, 'Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease) - Pipeline Review, H1 2014', provides an overview of the indication s therapeutic pipeline. This report provides information on the therapeutic development for Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease). Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease) - Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct s proprietary databases, Company/University websites, SEC filings, investor ...

The practical and free booklet covers diagnosis and care, looking after yourself, coping emotionally, involving family members and partners, carrying on with life and getting support from others.. Issues looked at include coping with tiredness and the side effects of drugs, sleeping, exercise, handling your feelings, living with a device, sex, pregnancy, working, driving and finances.. Contributors to the new guide include Cardiomyopathy UK's cardiomyopathy support nurses, and inherited heart disease nurse specialists and clinical psychologists from University College London Hospitals NHS Foundation Trust.. Thanks also goes to our supporters who donated towards the cost of publication.. The new booklet is designed to complement our booklets on the different types of cardiomyopathy (hypertrophic cardiomyopathy, dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy) which we produce with the British Heart Foundation. These look at the diseases, management of them and ...

Fourteen patients underwent right heart catheterization 5 to 86 months after pericardiectomy for constrictive pericarditis. Twelve had preoperative catheterizations, all with findings typical of constrictive pericarditis.. All patients showed marked hemodynamic and symptomatic improvement after operation. Three patients had persistent mild elevation of right heart and pulmonary artery pressures; one of these had a low cardiac output. Two other patients developed pulmonary hypertension with exercise, and one man showed an inadequate increase in cardiac output with exercise. Twelve patients were asymptomatic postoperatively and two had exertional dyspnea.. Patients with incomplete pericardiectomy over the ventricles had abnormal hemodynamic results, while decortication of the atria and venae cavae made no difference in the postoperative findings. A left anterolateral thoracotomy incision provided adequate exposure for pericardiectomy, and continues to be the incision of choice at this hospital. ...

Article, see p 1772. Early randomized clinical trials of primary prevention implantable cardioverter defibrillators (ICDs) in patients with nonischemic cardiomyopathy failed to establish survival benefit from this therapy; however, those trials were too small to provide definitive results.1,2 When the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) was published in 2005, it was practice changing. SCD-HeFT showed that primary prevention ICDs significantly improve the survival of patients with a left ventricular ejection fraction ≤35% attributable to ischemic or nonischemic cardiomyopathy and New York Heart Association class II or III heart failure symptoms despite optimal medical therapy.3 Patients with nonischemic cardiomyopathy constituted about half of the 2521 total enrolled patients in SCD-HeFT.3 The results of SCD-HeFT formed the basis of a class I guideline recommendation for primary prevention ICDs in patients with New York Heart Association class II or III heart failure symptoms ...

PMID: Curr Pharm Des. 2019 Jul 8. Epub 2019 Jul 8. PMID: 31298148 Abstract Title: Can Wogonin be Used in Controlling Diabetic Cardiomyopathy? Abstract: Diabetes Mellitus (DM) is now a well-known factor which initiates many metabolic derangements in various tissues and organs including liver, muscle, pancreas, adipose tissue, cardiovascular and nervous system. Cardiovascular complications are most important, and they are so intensively affected that their derangement leads to cardiac failure even in the absence of ischemic heart diseases. This entity of cardiac pathology in DM is often regarded as diabetic cardiomyopathy (DCM). Recently many plant derived drugs have been tested to control and alleviate DCM. Wogonin is one of the drugs whose characteristics has intensely been studied. Wogonin is a flavonoid which means they have yellow color pigment in their leaves and is obtained from the roots of plant Scutellaria Baicalensis Georgi. Wogonin has long been used as an active anti-cancer drug in ...

Kandula et al. Cardiovasc Diabetol (2016) 15:-DOI 10.1186/s12933-016-0361-1. Cardiovascular Diabetology. REVIEW Open Access. CrossMark. Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Vidya Kandula1, Ramoji Kosuru1, Haobo Li1, Dan Yan1, Qiqi Zhu1,2, Qingquan Lian2, Ren-shan Ge2, Zhengyuan Xia1,2* and Michael G. Irwin1. Abstract. Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understood. Some transcription factors have been suggested to regulate the gene program intricate in the pathogenesis of diabetes prompted cardiac injury. Forkhead box transcription factor 1 is a pleiotropic transcription factor that plays a pivotal role in a variety of physiological processes. Altered FOXO1 expression and function have been associated with cardiovascular diseases, and the important role of FOXO1 in DCM has begun to ...

TY - JOUR. T1 - Noonan syndrome. T2 - Structural abnormalities of the mitral valve causing subaortic obstruction. AU - Marino, B.. AU - Gagliardi, M. G.. AU - Digilio, M. C.. AU - Polletta, B.. AU - Grazioli, S.. AU - Agostino, D.. AU - Giannotti, A.. AU - Dallapiccola, B.. PY - 1995/12. Y1 - 1995/12. N2 - Conclusion: In children with Noonan syndrome and left ventricular hypertrophy a careful echocardiographic assessment of the mitral valve should reveal those in whom the left ventricular outflow tract obstruction is anatomical in nature. Among 41 consecutive children with classic Noonan syndrome, 27 patients (66%) presented cardiac anomalies. Eight patients (19.5%) had a congenital anomaly of the mitral valve consisting of 5 with partial atrioventricular canal defect and 3 with anomalous insertion of the mitral valve on the ventricular septum. Five patients (12%) presented with a significant left ventricular outflow tract obstruction caused by the anterior leaflet of the mitral valve: two cases ...

TY - JOUR. T1 - Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome). AU - McBride, Kim L.. AU - Zender, Gloria A.. AU - Fitzgerald-Butt, Sara M.. AU - Koehler, Daniel. AU - Menesses-Diaz, Andres. AU - Fernbach, Susan. AU - Lee, Kwanghyuk. AU - Towbin, Jeffrey A.. AU - Leal, Suzanne. AU - Belmont, John W.. PY - 2009/1/15. Y1 - 2009/1/15. N2 - The left ventricular outflow tract (LVOT) malformations aortic valve stenosis (AVS), coarctation of the aorta (CoA), and hypoplastic left heart syndrome (HLHS) are significant causes of infant mortality. These three malformations are thought to share developmental pathogenetic mechanisms. A strong genetic component has been demonstrated earlier, but the underlying genetic etiologies are unknown. Our objective was to identify genetic susceptibility loci for the broad phenotype of LVOT malformations. We genotyped 411 microsatellites spaced at an average of 10 cM ...

Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.

̣̣̣̺ Arrhythmogenic right ventricular dysplasia (ARVD), also called arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is an inherited heart disease.Wikipedia ARVD is caused by genetic defects of the parts of heart muscle (also called myocardium or cardiac muscle) known as desmosomes, areas on the surface of heart muscle cells which link the cells together. The desmosomes are composed of several proteins, and many of those proteins can have harmful mutations. The disease is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle. ARVD can be found in association with diffuse palmoplantar keratoderma, and woolly hair, in a autosomal recessive condition called Naxos disease, ...

The medical records of 118 patients (86 male, 32 female, age 10-50 (mean 27) years) who underwent pericardiectomy for constrictive pericarditis at the Christian Medical College Hospital, Vellore, from 1954 to 1985 were reviewed. All had appreciable pericardial constriction. Preoperatively 97 of the 118 were in class III or IV of the New York Heart Association classification and 100 had peripheral oedema or ascites. Tuberculosis was proved as the cause in 72 patients. Pericardiectomy was accomplished through a standard anterolateral thoracotomy (107 cases), median sternotomy (3 cases), or bilateral thoracotomy (8 cases). Postoperatively an apparent low cardiac output state was seen in 34 patients, 12 of whom died. Hospital mortality in the last 12 years was 11%. Mortality was higher in NYHA class III and IV patients. The improved surgical results recently may be related to increased use of inotropic support and prolonged ventilation. At follow up there were 72 patients in whom functional capacity ...

Familial Amyloid Polyneuropathy Therapeutics Market , 2021 Share, Growth, Trends, Demand, Key Players Analysis Report is latest report on Global Familial Amyloid Polyneuropathy Therapeutics Market Industry Published by Fortune Business Insights. Report covers key business segments and wide scope geographies to get deep dive analyzed industry data.. The company profiles of top Market players will provide financial analysis listing the company revenue, and market share. The past and present revenue of top players will offer forecast revenue estimates and growth rates. Familial Amyloid Polyneuropathy Therapeutics Market Industry Research Report provide the details about Industry Overview and analysis about Manufacturing Cost Structure, Revenue, Gross Margin, Consumption Value and Sale Price, Major Manufacturers, Distributors with Development Trends and Forecast 2026.. Browse More Information on This ...

Assess the prevalence of congenital heart disease (CHD) in a large population of mixed-breed dogs and cats.76,301 mixed-breed dogs and 57,025 mixed-breed cats.Retrospective review of records and examinations based on specified diagnostic criteria.Among mixed-breed dogs, the prevalence of CHD was 0.13% (51.4% female) and of innocent murmurs was 0.10% (53.0% male). Pulmonic stenosis was the most common defect followed by patent ductus arteriosus, aortic stenosis, and ventricular septal defect. Among mixed-breed cats, prevalence of CHD was 0.14% (55.2% male) and of innocent murmurs was 0.16% (54.4% male). When the 25 cats with dynamic left or right ventricular outflow obstruction were counted with cases of innocent murmurs, the overall prevalence was 0.2%. Ventricular septal defects were the most common feline CHD followed closely by aortic stenosis and hypertrophic obstructive cardiomyopathy. There was no overall sex predilection for CHD in mixed-breed cats or dogs, and no significant difference ...

Beth has been diagnosed with (PPCM) Peripartum Cardiomyopathy, also (POTS) Postural Orthostatic Tachycardia Syndrome, and (MCTD) Mixed Connective Tissue Disorder. For today we will focus on PPCM.. Due to the fact that only 1 in 3-5000 women will develop PPCM you are probably not familiar with the condition. That being said I have done a little research and I will pass on the basic details of PPCM. According to Johns Hopkins, "Peripartum cardiomyopathy is a weakness of the heart muscle that by definion begins sometime during the final month of pregnancy through about five months after delivery, without any other known cause. Most commonly, it occurs right after delivery. It is a rare condition that can carry mild or severe symptoms.". Symptoms of the condition include:. • Fatigue • Feeling of heart racing or skipping beats (palpitations). • Increased nighttime urination (nocturia) • Shortness of breath with activity and when lying flat. • Swelling of the ankles • Swollen neck veins. ...

Chest Pain Worse when Lying Down & Chronic Constrictive Pericarditis & Electrocardiogram Change Symptom Checker: Possible causes include Pericarditis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

Previous studies have shown that myocardial ischemia results in changes in the pattern of flow through the mitral valve (1-6). These changes in transmitral flow velocity pattern are most likely determined by disease-induced changes in the underlying diastolic properties of the heart (3,6-8). Knowing which diastolic properties determine the transmitral flow velocity pattern and how interactions between diastolic properties modify the overall transmitral flow velocity pattern would be helpful in understanding the hemodynamics of patients with myocardial ischemia.. Several transmitral flow velocity patterns have been reported during myocardial ischemia (5,6,8-10). In one pattern, early flow velocity is decreased, deceleration time is increased, and late flow velocity is increased (5,6,8). The diastolic determinant changed in this pattern is left ventricular relaxation, which is slowed. Slowed left ventricular relaxation is observed in some patients with dilated cardiomyopathy (11,12)and coronary ...

In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic:

Right ventricular dysplasia is characterized by an abnormality in the development of part of the right ventricular musculature. Patients with right ventricular dysplasia may present with ventricular tachycardia, supraventricular arrhythmias, right-heart failure or asymptomatic cardiomegaly. Twenty-two adult patients with right ventricular dysplasia who had recurrent ventricular tachycardia were seen during a 7-year period. The male/female ratio was 2.7:1. The mean age at the time of hospitalization was 39 years. All but one of the patients had ventricular tachycardia of a left bundle branch block configuration. With few exceptions, the T waves were inverted over the right precordial leads. The heart was usually enlarged and the pulmonary vasculature was usually normal. In six patients who had two-dimensional echocardiograms, all showed increased right ventricular diastolic dimensions. All patients had right ventricular angiography; the diagnosis of right ventricular dysplasia was substantiated ...

Boxer cardiomyopathy (also known as "Boxer arrhythmogenic right ventricular cardiomyopathy") is a disease of the myocardium primarily affecting Boxer dogs. It is characterized by the development of ventricular tachyarrhythmias, resulting in syncope and sudden cardiac death. Myocardial failure and congestive heart failure are uncommon manifestations of the disease. Boxer cardiomyopathy shares striking similarities to a human myocardial disease called arrhythmogenic right ventricular cardiomyopathy (ARVC). On histopathology, the disease is characterized by the progressive replacement of ventricular myocardium (primarily right ventricular myocardium) with fatty or fibro-fatty tissue. Clinically, the disease is characterized by the development of ventricular tachyarrhythmias, including ventricular tachycardia and ventricular fibrillation. Affected dogs are at risk of syncope and sudden cardiac death. Boxer cardiomyopathy is a genetic disease inherited in an autosomal dominant pattern. The ...

The literature on right ventricular systolic dysfunction (RVSD) in peripartum cardiomyopathy (PPCM) patients is scanty, and it appears that RV reverse remodelling in PPCM has not been previously described. This study thus aimed to assess RVSD and remodelling in a cohort of PPCM patients in Kano, Nigeria. A longitudinal study carried out in 3 referral hospitals in Kano, Nigeria. Consecutive PPCM patients who had satisfied the inclusion criteria were recruited and followed up for 12 months. RVSD was defined as the presence of either tricuspid annular plane systolic excursion (TAPSE) |16 mm or peak systolic wave (S') tissue Doppler velocity of RV free wall |10 cm/s. For the purpose of this study, recovery of RV systolic function was defined as an improvement of reduced TAPSE to ≥16 mm or S' to ≥10 cm/s, without falling to reduced levels again, during follow-up. A total of 45 patients were recruited over 6 months with a mean age of 26.6 ± 7.0 years. RV systolic function recovery occurred in a total of

Prognosis: "Most patients with acute pericarditis (generally those with presumed viral or idiopathic pericarditis) have a good long-term prognosis.Cardiac tamponade rarely occurs in patients with acute idiopathic pericarditis, and is more common in patients with a specific underlying aetiology such as malignancy, TB or purulent pericarditis. Constrictive pericarditis may occur in ,1% of patients with acute idiopathic pericarditis, and is also more common in patients with a specific aetiology. The risk of developing constriction can be classified as low (,1%) for idiopathic and presumed viral pericarditis; intermediate (2-5%) for autoimmune, immune-mediated and neoplastic aetiologies; and high (20-30%) for bacterial aetiologies, especially with TB and purulent pericarditis.36 Approximately 15-30% of patients with idiopathic acute pericarditis who are not treated with colchicine will develop either recurrent or incessant disease, while colchicine may halve the recurrence rate.". Notes:. ...

BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.

Our study is the first to document that HDAC inhibition preserves cardiac performance and suppresses cardiac remodeling in diabetic cardiomyopathy. Specifically, (1) Serial echocardiographic evaluation indicates that HDAC inhibition resulted in the preservation of ventricular function in STZ-induced diabetic heart; (2) HDAC inhibition plays a profound effect in suppressing interstitial fibrosis and attenuating myocyte hypertrophy in the diabetic myocardium; (3) HDAC inhibition mitigated the frequencies of apoptosis in the diabetic myocardium by decreasing active caspase 3 and TUNEL positive signals; (4) HDAC inhibition resulted in the increase of SOD1, GLUT1, and GLUT4 protein levels in diabetic hearts, and acetylation of GLUT1 was elevated following HDAC inhibition; (5) Diabetic hearts exhibited significant decreases in CD31 and α-SMA positive microvessels, which was prevented following HDAC inhibition.. Recent evidence has indicated a genetic association between diabetes and HDACs. HDAC ...

TY - JOUR. T1 - The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. AU - Liu, Bing. AU - Salgado, Oscar C.. AU - Singh, Sangya. AU - Hippen, Keli L.. AU - Maynard, Jason C.. AU - Burlingame, Alma L.. AU - Ball, Lauren E.. AU - Blazar, Bruce R.. AU - Farrar, Michael A.. AU - Hogquist, Kristin A.. AU - Ruan, Hai Bin. PY - 2019/12/1. Y1 - 2019/12/1. N2 - Regulatory T (Treg) cells control self-tolerance, inflammatory responses and tissue homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage identity, while T cell receptor (TCR) signaling and interleukin-2 (IL-2)/STAT5 activation support the suppressive effector function of Treg cells, but how these regulators synergize to control Treg cell homeostasis and function remains unclear. Here we show that TCR-activated posttranslational modification by O-linked N-Acetylglucosamine (O-GlcNAc) stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways. ...

Conclusion: Our findings indicate that myocardial damage in patients with diabetes affects diastolic function before systolic function.Even young patients with diabetics with normal systolic ventricular function have diastolic dysfunction, which serves as a marker of a diabetic cardiomyopathy. Diastolic impairment seems not to correlate with disease duration. HbA1c% can be a very good indicator of long term prognosis. Strong correlation exist between diastolic dysfunction and HbA1c%.. ...

This unit will enhance students' understanding of cardiovascular risk, and the cardiovascular complications that may occur in metabolic disease. It will facilitate increased confidence in the assessment, prevention and practical medical management of cardiovascular disease in its broadest sense. Epidemiology and pathophysiology of atherogenesis and cardiovascular disease, will be addressed followed by an intensive focus on characterisation and patient-centred management of common modifiable cardiovascular risk factors including hypertension, lipoprotein disorders, diabetes and liftestyle factors pertinent to cardiovascular health. Evidence based screening and diagnostic methods, lifestyle interventions, pharmacotherapy and non-invasive monitoring will be covered. This will be followed by a detailed exploration of large and small vessel disease and implications of metabolic disease for brain, kidney and heart function (including ischaemic cardiomyopathy, diabetic cardiomyopathy and hypertensive ...