On Thu, 11 Mar 2004 13:16:15 -0500 XIAO LIU ,xiaoliu at jhmi.edu, wrote: , Dear R-helpers: , , I want to calculate area under a Receiver Operator Characteristic curve. , Where can I find related functions? , , Thank you in advance , , Xiao , install.packages(Hmisc) library(Hmisc) w ,- somers2(predicted probability, 0/1 diagnosis) Convert Somers Dxy rank correlation to ROC area (C) using Dxy=2*(C-.5). To get standard error of Dxy (and hence C) type ?rcorr.cens (another Hmisc function). This is the nonparametric Wilcoxon-Mann-Whitney approach. --- Frank E Harrell Jr Professor and Chair School of Medicine Department of Biostatistics Vanderbilt University ...
Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often reached through inconsistent use or insufficient statistical analysis. To support researchers in their ROC curves analysis we developed pROC, a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface. With data previously imported into the R or S+ environment, the pROC package builds ROC curves and includes functions for computing confidence intervals, statistical tests for comparing total or partial area under the curve or the operating points of different classifiers, and methods for smoothing ROC curves. Intermediary and final results are visualised in user-friendly interfaces. A case study based on published clinical and biomarker data shows how to perform a typical ROC analysis with pROC. pROC is a package for R and S+
ROC curve is used to evaluate classification models. Learn threshold tuning, ROC curve in Machine Learning,area under roc curve , and ROC curve analysis in Python.
TY - JOUR. T1 - Mutual information as a performance measure for binary predictors characterized by both roc curve and proc curve analysis. AU - Hughes, Gareth. AU - Kopetzky, Jennifer. AU - McRoberts, Neil. PY - 2020/9. Y1 - 2020/9. N2 - The predictive receiver operating characteristic (PROC) curve differs from the more well-known receiver operating characteristic (ROC) curve in that it provides a basis for the evaluation of binary diagnostic tests using metrics defined conditionally on the outcome of the test rather than metrics defined conditionally on the actual disease status. Application of PROC curve analysis may be hindered by the complex graphical patterns that are sometimes generated. Here we present an information theoretic analysis that allows concurrent evaluation of PROC curves and ROC curves together in a simple graphical format. The analysis is based on the observation that mutual information may be viewed both as a function of ROC curve summary statistics (sensitivity and ...
How is the cutoff point actually determined? This can be based on a pure mathematical analysis to either minimize the mathematical distance between the receiver operator characteristic curve and the ideal point (sensitivity = specificity = 1) or to maximize the difference (Youden index) between the receiver operator characteristic curve and the diagonal or chance line (sensitivity + specificity − 1). Whereas the first approach minimizes misclassification, the second one maximizes appropriate classification.4 An alternative approach will also take into account the cost-benefit ratio of the consequence of having either false-positive or false-negative results. One can easily appreciate that in certain pathologic conditions, treatment of a patient with a false-positive result may be worse than missing a false-negative result or conversely that not treating a patient with a false-negative result may be worse than treating one with a false-positive result. In the case of PPV assessment, a low ...
Clinical practice commonly demands yes or no decisions; and for this reason a clinician frequently needs to convert a continuous diagnostic test into a dichotomous test. Receiver operating characteristic (ROC) curve analysis is an important test for assessing the diagnostic accuracy (or discrimina …
Decided to start githib with ROC curve plotting example. There is not a one ROC curve but several - according to the number of comparisons (classifications), also legend with maximal and minimal ROC AUC are added to the plot. ROC curves and ROC AU...
In receiver operating characteristic ROC curve analysis, the optimal cutoff value for a diagnostic test can be found on the ROC curve where the slope of the curve is equal to C/B x 1-pD/pD, where pD is the disease prevalence and C/B is the ratio of net costs of treating nondiseased individuals to net benefits of treating diseased individuals....
from sklearn.metrics import roc_curve, auc ### Fit a sklearn classifier on train dataset and output probabilities pred_val = svc.predict_proba(self.X_test)[:,1] ### Compute ROC curve and ROC area for predictions on validation set fpr, tpr, _ = roc_curve(self.y_test, pred_val) roc_auc = auc(fpr, tpr) ### Plot plt.figure() lw = 2 plt.plot(fpr, tpr, color=darkorange, lw=lw, label=ROC curve (area = %0.2f) % roc_auc) plt.plot([0, 1], [0, 1], color=navy, lw=lw, linestyle=--) plt.xlim([0.0, 1.0]) plt.ylim([0.0, 1.05]) plt.xlabel(False Positive Rate) plt.ylabel(True Positive Rate) plt.title(Receiver operating characteristic example) plt.legend(loc=lower right) plt.show ...
A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the rating method, or by mathematical predictions based on patient characteristics, is presented. It is shown that in such a setting the area represents the probability that a randomly …
Read The meaning and use of the area under a receiver operating characteristic (ROC) curve., Radiology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Receiver operating characteristic (ROC) curve is an effective and widely used method for evaluating the discriminating power of a diagnostic test or statistical model. As a useful statistical method, a wealth of literature about its theories and computation methods has been established. The research on ROC curves, however, has focused mainly on cross-sectional design. Very little research on estimating ROC curves and their summary statistics, especially significance testing, has been conducted for repeated measures design. Due to the complexity of estimating the standard error of a ROC curve, there is no currently established statistical method for testing the significance of ROC curves under a repeated measures design. In this paper, we estimate the area of a ROC curve under a repeated measures design through generalized linear mixed model (GLMM) using the predicted probability of a disease or positivity of a condition and propose a bootstrap method to estimate the standard error of the area ...
OBJECTIVE:To assess the relationships between fluid and imaging biomarkers of tau pathology and compare their diagnostic utility in a clinically heterogeneous sample. METHODS:Fifty-three patients (28 with clinical Alzheimer disease [AD] and 25 with non-AD clinical neurodegenerative diagnoses) underwent β-amyloid (Aβ) and tau ([18F]AV1451) PET and lumbar puncture. CSF biomarkers (Aβ42, total tau [t-tau], and phosphorylated tau [p-tau]) were measured by multianalyte immunoassay (AlzBio3). Receiver operator characteristic analyses were performed to compare discrimination of Aβ-positive AD from non-AD conditions across biomarkers. Correlations between CSF biomarkers and PET standardized uptake value ratios (SUVR) were assessed using skipped Pearson correlation coefficients. Voxelwise analyses were run to assess regional CSF-PET associations. RESULTS:[18F]AV1451-PET cortical SUVR and p-tau showed excellent discrimination between Aβ-positive AD and non-AD conditions (area under the curve ...
Most microarray experiments are carried out with the purpose of identifying genes whose expression varies in relation with specific conditions or in response to environmental stimuli. In such studies, genes showing similar mean expression values between two or more groups are considered as not differentially expressed, even if hidden subclasses with different expression values may exist. In this paper we propose a new method for identifying differentially expressed genes, based on the area between the ROC curve and the rising diagonal (ABCR). ABCR represents a more general approach than the standard area under the ROC curve (AUC), because it can identify both proper (i.e., concave) and not proper ROC curves (NPRC). In particular, NPRC may correspond to those genes that tend to escape standard selection methods. We assessed the performance of our method using data from a publicly available database of 4026 genes, including 14 normal B cell samples (NBC) and 20 heterogeneous lymphomas (namely: 9
Compared to those with bacterial or mixed infection (n = 9), patients with 2009 H1N1 infection (n = 16) were significantly more likely to have bilateral chest X-ray infiltrates, lower APACHE scores, more prolonged lengths of stay in ICU and lower white cell count, procalcitonin and CRP levels. Using a cutoff of ,0.8 ng/ml, the sensitivity and specificity of procalcitonin for detection of patients with bacterial/mixed infection were 100 and 62%, respectively. A CRP cutoff of ,200 mg/l best identified patients with bacterial/mixed infection (sensitivity 100%, specificity 87.5%). In combination, procalcitonin levels ,0.8 ng/ml and CRP ,200 mg/l had optimal sensitivity (100%), specificity (94%), negative predictive value (100%) and positive predictive value (90%). Receiver-operating characteristic curve analysis suggested the diagnostic accuracy of procalcitonin may be inferior to CRP in this setting.. ...
On Jun 26, 2017, at 11:40 AM, Brian Smith ,bsmith030465 at gmail.com, wrote: , , Hi, , , I was trying to draw some ROC curves (prediction of case/control status), , but seem to be getting a somewhat jagged plot. Can I do something that , would smooth it somewhat? Most roc curves seem to have many incremental , changes (in x and y directions), but my plot only has 4 or 5 steps even , though there are 22 data points. Should I be doing something differently? , , How can I provide a URL/attachment for my plot? Not sure if I can provide , reproducible code, but here is some pseudocode, let me know if youd like , more details: , , ##### , ## generate roc and auc values , ##### , library(pROC) , library(AUCRF) , , getROC ,- function(d1train,d1test){ , my_model ,- AUCRF(formula= status ~ ., data=d1train, , ranking=MDA,ntree=1000,pdel=0.05) , my_opt_model ,- my_model$RFopt , , my_probs ,- predict(my_opt_model, d1test, type = prob) , my_roc ,- roc(d1test[,resp_col] ~ my_probs[,2]) , aucval ,- ...
The introduction of digital CXR with automated computer-aided interpretation, has given impetus to the role of CXR in TB screening, particularly in low resource, high-burden settings. The aim of this study was to evaluate the diagnostic accuracy of CAD4TB as a screening tool, implemented in the private sector in Karachi, Pakistan. This study analyzed retrospective data from CAD4TB and Xpert MTB/RIF testing carried out at two private TB treatment and diagnostic centers in Karachi. Sensitivity, specificity, potential Xperts saved, were computed and the receiver operator characteristic curves were constructed for four different models of CAD4TB. A total of 6,845 individuals with presumptive TB were enrolled in the study, 15.2% of which had MTB + ve result on Xpert. A high sensitivity (range 65.8-97.3%) and NPV (range 93.1-98.4%) were recorded for CAD4TB. The Area under the ROC curve (AUC) for CAD4TB was 0.79. CAD4TB with patient demographics (age and gender) gave an AUC of 0.83. CAD4TB offered high ...
Life is full of surprises. When I was looking at whether the software package R could compute and analyze Receiver Operating Characteristic (ROC) curves, I found out that there is an application of ROC curves for microarray data. Apparently, the positive false discovery rate can be conceived of in a diagnostic testing format as relating to the positive predictive value. I have not had time to read all the details, but there is a nice paper on this at. ...
To determine if the manufacturers cutoff criteria were optimal, ROC curves were generated. The ViraBlot assay produced an ROC curve with an area under the curve (AUC) of 0.988 (P , 0.0001). The optimal cutoff criterion for maximum sensitivity and specificity matched the manufacturers protocol. For the Virotech assay, an ROC curve with an AUC of 0.987 (P , 0.0001) was produced. This ROC curve indicated that by reducing the cutoff criterion by one band, the sensitivity could be increased from 90.0% to 98.4% (95% CI, 93.6 to 99.7%) without significantly decreasing the specificity. This would reduce the number of false-negative results. The Marblot assay produced an ROC curve with an AUC of 0.988 (P , 0.0001). The ROC curve indicated that by reducing the cutoff criterion by one, the number of equivocal results would decrease from 25 to 14 without significantly decreasing sensitivity or specificity. However, this is still an unacceptably high number of equivocal samples.. Although FTA-ABS testing ...
Paul R. Yarnold Optimal Data Analysis, LLC Receiver operator characteristic (ROC) analysis is sometimes used to assess the classification accuracy achieved using an ordered attribute to discriminate a dichotomous class variable, and in this context to identify an
TY - GEN. T1 - Optimizing sensitivity-resolution trade-off using generalized detection/discrimination task and three-class ROC analysis. AU - Volokh, Lana. AU - He, Xin. AU - Frey, Eric C.. AU - Tsui, B. M.W.. PY - 2006/1/1. Y1 - 2006/1/1. N2 - The goal of this work is to address the problem of quantifying sensitivity/resolution trade-off in emission imaging system optimization. We propose a task and a figure of merit (FOM) based on 3-class ROC analysis. The task combines detection of a lesion on a variable background with discrimination of a lesion from an adjacent structure, modeled by Rayleigh task. Recently developed practical framework for conducting 3-class ROC analysis is utilized to evaluate the performance of channelized hotelling observer. A primitive imaging system model is used to investigate effects of resolution, sensitivity and imaging time. Volume under ROC surface (VUS) is used as the primary FOM in assessment of the task performance. The FOM is optimal according to several ...
After 2.4 ± 2.1 years, there were 11 cardiac deaths (event rate 7.6%/year). The causes of death were worsening congestive heart failure and arrhythmia. Fatal or nonfatal myocardial infarctions were not observed. Twelve patients died of noncardiac causes (8 due to infections) and were censored at the time of death. The overall survival rate at the end of the study period was 62%. Receiver-operating characteristic curve analysis demonstrated a significant association between ΔWMSI and cardiac death. A cut point value for ΔWMSI of 0.38 predicted cardiac death with a specificity of 88% and a sensitivity of 73% (area under the curve = 0.75, 95% CI: 0.54 to 0.97; p = 0.01). Using this cut point value of ΔWMSI, we stratified the study group into patients with ICR and patients without ICR. There were no significant differences between the groups in the presence of cardiovascular risk factors or the use of antiremodeling medications. The group without ICR was more frequently taking diuretics (75% vs. ...
The majority of patients develop resistance against suppression of HER2-signaling mediated by trastuzumab in HER2 positive breast cancer (BC). HER2 overexpression activates multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade. MAPK phosphatases (MKPs) are essential regulators of MAPKs and participate in many facets of cellular regulation, including proliferation and apoptosis. We aimed to identify whether differential MKPs are associated with resistance to targeted therapy in patients previously treated with trastuzumab. Using gene chip data of 88 HER2-positive, trastuzumab treated BC patients, candidate MKPs were identified by Receiver Operator Characteristics analysis performed in R. Genes were ranked using their achieved area under the curve (AUC) values and were further restricted to markers significantly associated with worse survival. Functional significance of the two strongest predictive markers was evaluated in vitro by gene silencing in HER2 ...
We performed the iterative outlier method on 373 cognitively unimpaired (CU) subjects and calculated the optimal cutoff value for Aβ positivity. The validation was performed using the independent dataset, comprising 83 subjects (27 CU, 27 amnestic mild cognitive impairment, and 29 Alzheimers dementia). We evaluated the validity of the Aβ cutoff value by calculating its concordance rate with the visual assessment and between two different Aβ tracers performed in the same subject ...
Ch17-18 (ROC Curve: receiver operating characteristics, curving up and to…: Ch17-18 (ROC Curve: receiver operating characteristics, curving up and to the left is better unless its a corner (target leakage) , Still minimal understanding of models beyond introductory info, CH18: comparing model pairs, AOC= area under curve, good= low FPR and high TPR)
Receiver Operating Characteristic (ROC) curves are frequently used in biomedical informatics research to evaluate classification and prediction models to support decision, diagnosis, and prognosis. ROC analysis investigates the accuracy of models and ability to separate positive from negative cases. It is especially useful in evaluating predictive models and in comparing ...
TY - GEN. T1 - Rate-oriented point-wise confidence bounds for ROC curves. AU - Millard, Louise A C. AU - Kull, Meelis. AU - Flach, Peter A.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Common approaches to generating confidence bounds around ROC curves have several shortcomings. We resolve these weaknesses with a new rate-oriented approach. We generate confidence bounds composed of a series of confidence intervals for a consensus curve, each at a particular predicted positive rate (PPR), with the aim that each confidence interval contains new samples of this consensus curve with probability 95%. We propose two approaches; a parametric and a bootstrapping approach, which we base on a derivation from first principles. Our method is particularly appropriate with models used for a common type of task that we call rate-constrained, where a certain proportion of examples needs to be classified as positive by the model, such that the operating point will be set at a particular PPR value. © 2014 ...
Someone asked me about how to use an ROC curve if you have more than two categories. Apparently the gold standard that the researchers were using was known to be imperfect, so they wanted an intermediate category (possible disease).. There s a lot of literature about less than perfect gold standards, and you should familiarize yourself with that first. Creating an intermediate category is not the best way to handle an imperfect gold standard. Often the best approach when there is an imperfect gold standard is to apply a second or third different (but still imperfect, of course) gold standard.. As far as I know, there is no way to adapt the ROC curve to more than two groups. You can, however, use a different model, such as ordinal logistic regression to see how well your diagnostic test predicts in the three categories.. If all of this seems too complicated, consider dropping the middle group or combining it with one of the other two groups. You already know that it is less than ideal, but it may ...
ROC curves of the SPAN, TSQ and IES-R for 6 month PTSD.Note: ROC curves represent original sensitivity and specificity values using linear interpolation between
Hi guys! I am trying to determine the best cut off value for a single diagnostic test by performing the ROC curve analysis. The diagnostic test has AUC of...
Use ROC curves to assess classification models. Walk through several examples that illustrate what ROC curves are and why youd use them.
The predictive accuracy of a survival model can be summarized using extensions of the proportion of variation explained by the model, or R2, commonly used for continuous response models, or using extensions of sensitivity and specificity, which are commonly used for binary response models. In this article we propose new time-dependent accuracy summaries based on time-specific versions of sensitivity and specificity calculated over risk sets. We connect the accuracy summaries to a previously proposed global concordance measure, which is a variant of Kendalls tau. In addition, we show how standard Cox regression output can be used to obtain estimates of time-dependent sensitivity and specificity, and time-dependent receiver operating characteristic (ROC) curves. Semiparametric estimation methods appropriate for both proportional and nonproportional hazards data are introduced, evaluated in simulations, and illustrated using two familiar survival data sets.. ...
ROC curve and false discovery rates (FDR) for phenotypic similarities between diseases provided by PhenUMA and PhenomeNET. A: ROC curves for phenotypic similari
The area under the receiver operating characteristic (ROC) curve, referred to as the AUC, is an appropriate measure for describing the overall accuracy of a diagnostic test or a biomarker in early phase trials without having to choose a threshold. There are many approaches for estimating the confidence interval for the AUC. However, all are relatively complicated to implement. Furthermore, many approaches perform poorly for large AUC values or small sample sizes. The AUC is actually a probability. So we propose a modified Wald interval for a single proportion, which can be calculated on a pocket calculator. We performed a simulation study to compare this modified Wald interval (without and with continuity correction) with other intervals regarding coverage probability and statistical power. The main result is that the proposed modified Wald intervals maintain and exploit the type I error much better than the intervals of Agresti-Coull, Wilson, and Clopper-Pearson. The interval suggested by Bamber, the
Function to estimate the ROC Curve of a continuous-scaled diagnostic test with the help of a second imperfect diagnostic test with binary responses.
Excel tool for Analysis of single ROC curve (receiver operating characteristics): Graph, calculation of AUC incl. confidence intervals
ROC/AUC methods. fast.auc calculates the AUC using a sort operation, instead of summing over pairwise differences in R. computeRoc computes an ROC curve. plotRoc plots an ROC curve. addRoc adds an ROC curve to a plot. classification.error computes classification error
A ROC curve is a graph that plots true positive rates against false positive rates for a series of cutoff values, or in other words, graphically displays the trade-off between sensitivity and specificity for each cutoff value. An ideal cutoff might give the test the highest possible sensitivity with the lowest possible false positive rate (i.e., highest specificity). This is the point lying geometrically closest to the top-left corner of the graph (where the ideal cutoff value with 100% sensitivity and specificity would be plotted). Picking the ideal cutoff score is, to some extent, dependent on the clinical context, that is the purpose for which the tool will be used. The area under an ROC curve can be used as an overall estimate of its discriminating ability and sometimes is expressed as accuracy. The area under the ROC curve is equal to the probability that a test correctly classifies patients as true positives or true negatives. Greater areas under the curve indicate higher accuracy. To ...
To identify putative blood-based MS biomarkers, we comprehensively interrogated the metabolite profiles in 12 non-Hispanic white, non-smoking, male MS cases who were drug naïve for 3 months prior to biospecimen collection and 13 non-Hispanic white, non-smoking male controls who were frequency matched to cases by age and body mass index. We performed untargeted two-dimensional gas chromatography and time-of-flight mass spectrometry (GCxGC-TOFMS) and targeted lipidomic and amino acid analysis on serum. 325 metabolites met quality control and supervised machine learning was used to identify metabolites most informative for MS status. The discrimination potential of these select metabolites were assessed using receiver operator characteristic curves based on logistic models; top candidate metabolites were defined as having area under the curves (AUC) ,80%. The associations between whole-genome expression data and the top candidate metabolites were examined, followed by pathway enrichment analyses. ...
Studies evaluating a new diagnostic imaging test may select control subjects without disease who are similar to case subjects with disease in regard to factors potentially related to the imaging result. Selecting one or more controls that are matched to each case on factors such as age, comorbidities, or study site improves study validity by eliminating potential biases due to differential characteristics of readings for cases versus controls. However, it is not widely appreciated that valid analysis requires that the receiver operating characteristic (ROC) curve be adjusted for covariates. We propose a new computationally simple method for estimating the covariate-adjusted ROC curve that is appropriate in matched case-control studies.. We provide theoretical arguments for the validity of the estimator and demonstrate its application to data. We compare the statistical properties of the estimator with those of a previously proposed estimator of the covariate-adjusted ROC curve. We demonstrate an ...
Figure 3: Receiver operator characteristic curve (ROC) assessing the validity of the anti-MCV test in diagnosing RA. The area under the curve was 0.893 at the 95% CI. The sensitivity of each test is plotted against one minus specificity for varying cutoffs (values lower than the cutoff were considered negative, and other values were considered positive) (n= 40 ...
In my ROC curve analysis output, on the table «Coordinates of the curve» there is a footnote saying « All the other cutoff values are the averages of two consecutive ordered observed test values». How can I know the Sensitivity and Specificity for each OBSERVED VALUE (not for means of observed values ...
This example shows how you can assess the performance of both coherent and noncoherent systems using receiver operating characteristic (ROC) curves.
This example shows how you can assess the performance of both coherent and noncoherent systems using receiver operating characteristic (ROC) curves.
This example shows how you can assess the performance of both coherent and noncoherent systems using receiver operating characteristic (ROC) curves.
BACKGROUND Fatal cases of COVID-19 are increasing globally. We retrospectively investigated the potential of immunologic parameters as early predictors of COVID-19.METHODS A total of 1018 patients with confirmed COVID-19 were enrolled in our 2-center retrospective study. Clinical feature, laboratory test, immunological test, radiological findings, and outcomes data were collected. Univariate and multivariable logistic regression analyses were performed to evaluate factors associated with in-hospital mortality. Receiver operator characteristic (ROC) curves and survival curves were plotted to evaluate their clinical utility.RESULTS The counts of all T lymphocyte subsets were markedly lower in nonsurvivors than in survivors, especially CD8+ T cells. Among all tested cytokines, IL-6 was elevated most significantly, with an upward trend of more than 10-fold. Using multivariate logistic regression analysis, IL-6 levels of more than 20 pg/mL and CD8+ T cell counts of less than 165 cells/μL were found ...
Dirk Tasche of Deutsche Bundesbank. November 2002. Abstract: Assessing the discriminative power of rating systems is an important question to banks and to regulators. In this article we analyze the Cumulative Accuracy Profile (CAP) and the Receiver Operating Characteristic (ROC) which are both commonly used in practice. We give a test-theoretic interpretation for the concavity of the CAP and the ROC curve and demonstrate how this observation can be used for more efficiently exploiting the informational contents of accounting ratios. Furthermore, we show that two popular summary statistics of these concepts, namely the Accuracy Ratio and the area under the ROC curve, contain the same information and we analyse the statistical properties of these measures. We show in detail how to identify accounting ratios with high discriminative power, how to calculate confidence intervals for the area below the ROC curve, and how to test if two rating models validated on the same data set are different. All ...
Background: Due to the faltering sensitivity and/or specificity, urine-based assays currently have a limited role in the management of patients with bladder cancer (BCa). The aim of this study was to externally validate our previously reported protein biomarker panel from multiple sites in the US and Europe. Methods: This multicenter external validation study included a total of 320 subjects (BCa = 183). The 10 biomarkers (IL8, MMP9, MMP10, SERPINA1, VEGFA, ANG, CA9, APOE, SDC1 and SERPINE1) were measured using commercial ELISA assays in an external laboratory. The diagnostic performance of the biomarker panel was assessed using receiver operator curves (ROC) and descriptive statistical values. Results: Utilizing the combination of all 10 biomarkers, the AUROC for the diagnostic panel was noted to be 0.847 [95% CI: 0.796 - 0.899], outperforming any single biomarker. The multiplex assay at optimal cutoff value achieved an overall sensitivity of 0.79, specificity of 0.79, PPV of 0.73 and NPV of ...