Define identity element. identity element synonyms, identity element pronunciation, identity element translation, English dictionary definition of identity element. n. The element of a set of numbers that when combined with another number in a particular operation leaves that number unchanged. For example, 0 is the...
The JSU web identity standards include required and recommended components. These standards apply to all sites revamped or created as part of the JSU website redesign and development in 2012, and to all sites created thereafter. For sites outside the scope of the project, we strongly encourage JSU to incorporate the standards as soon as possible.. ...
富永真琴「温度感受性TRP チャネルの生理機能と創薬標的としての意義」,第38 回生体膜と薬物の相互作用 シンポジウム,名古屋,2016 年11 月. ...
The Joomla! logo consists of the logotype and the mark. The mark represents what Joomla is about...a community coming together as one. The mark is made up of four "Js" rotated and linked together that represent the community coming together as one. The images combining the logo and the Joomla! name have been developed to promote high visibility of the mark balanced with clear legibility of the name. When used as part of the signature, the colours of the brandmark should never be altered in any way. Joomla! has two different brandmarks, the flat version (official) and 3D version (optional). We ask that you avoid using both of the brandmark styles in a given project. Instead, we recommend choosing one of the two brandmarks for each specific design project in order to give a consistent and coherent representation of our brand. The relationship (size, positioning, colours, etc.) of the brand identity elements should never be altered in any way. ...
The purpose of this study was to develop a tumor-targeted therapeutic to antagonize aberrantly expressed microRNAs in lymphoma. MicroRNA dysfunction has been linked to the onset cancer. For example, in lymphoma miR-155 can affect carcinogenesis by acting as a hyperexpressed microRNA oncogene, or oncomiR. As ubiquitous regulators of gene expression, microRNAs are promising therapeutic targets. As such, numerous recent preclinical and clinical studies have utilized therapeutic oligonucleotides, known as antimiRs, to bind to and inhibit disease-associated microRNAs. However, the efficacy of systemically administered antimiRs is hindered by non-specific tissue targeting, which typically results in substantial liver uptake.. We have developed an antimiR-peptide conjugate which preferentially targets the acidic tumor microenvironment. Intravital imaging and confocal tissue analysis show that this conjugate accumulates in tumors, while avoiding the liver, and has no observable systemic or cellular ...
Enterovirus 71 (EV-A71) receptors that have been identified to date cannot fully explain the pathogenesis of EV-A71, which is an important global cause of hand-foot-and-mouth disease and life-threatening encephalitis. We identified an interferon-gamma (IFNγ)-inducible EV-A71 cellular entry factor, human tryptophanyl-tRNA synthetase (hWARS), using genome-wide RNAi library screening. The importance of hWARS in mediating virus entry and infectivity was confirmed by virus attachment, in vitro pull-down, antibody/antigen blocking, and CRISPR/Cas9. Upon IFNγ treatment, induced hyperexpression and plasma membrane translocation of hWARS were observed, which sensitized semi-permissive (human neuronal NT2)/non-permissive (mouse fibroblast L929) cells to EV-A71 infection. Our hWARS-transduced mouse infection model showed pathological changes similar to patients with severe EV-A71 infection. The expression of hWARS is also required for productive infection by other human enteroviruses, including the ...
1MB2: Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
1M83: Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
Starting with a single-cell RNA-seq dataset consisting of 259 mouse embryonic cells derived from zygote to blastocyst stages, we reconstructed the temporal and spatial gene expression pattern during PD. The dynamics of gene expression can be partially explained by the enrichment of transposable elements in gene promoters and the similarity of expression profiles with those of corresponding transposons. Long Terminal Repeats (LTRs) are associated with transient, strong induction of many nearby genes at the 2-4 cell stages, probably by providing binding sites for Obox and other homeobox factors. B1 and B2 SINEs (Short Interspersed Nuclear Elements) are correlated with the upregulation of thousands of nearby genes during zygotic genome activation. Such enhancer-like effects are also found for human Alu and bovine tRNA SINEs. SINEs also seem to be predictive of gene expression in embryonic stem cells (ESCs), raising the possibility that they may also be involved in regulating pluripotency. We also ...
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Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection / Y H Ahn; S Park; J J Choi; B K Park; K H Rhee; E Kang; S Ahn; Chul Ho Lee; J S Lee; K S Inn; M L Cho; S H Park; K Park; H J Park; J H Lee; J W Park; N H Kwon; H Shim; B W Han; P Kim; J Y Lee; Y Jeon; J W Huh; M Jin; S Kim , 2016 ...
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I would think that the only way around parity obstruction would have to begin by permitting the identity elements, 0,1, to be considered "conditionally prime" within the trivial range ,4, thereby generalizing the binary G conjecture to a full set Z. From there, considering that the identity elements are also perfect squares, the binary G could be restated as, Every perfect square is the sum of a semiprime and another perfect square, thus fully relating the additive and multiplicative universes, and which would make for an easier conjecture to address. These tough NT problems are really only related to the fact that axiomatic systems in general, are simply constructive edifices honoring a much deeper bilateral symmetry condition that is a pre-conditional for all arithmetic axioms, terms and relations. The only way you will find easy proofs for these problems is to generalize them over the entire Z. Unfortunately, the symmetric beauty of the primes is spoiled by the conventionalities ...
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Thanks for the comment Yasin, youve hit a very good point square on the head.. Youre completely right that peoples awareness of the need for distinctiveness is a separate thing from the need we measured. Our measure of the strength of the distinctiveness motive is more implicit than simply getting people to tell us how distinctive they want to be; we compute the within-person correlation between how distinctive they rate each identity element, and how important that element is to who they are. Those with a stronger need for distinctiveness show more positive within-person correlations; they rate their more distinctive identity elements as more important to their sense of self. Weve actually found that this measure gives rather different results from measures asking explicitly about how distinctive people want to be (such as SANU, Lynn & Harris, 1997). What we think is going on - and this is really interesting - is that the explicit measures actually tap into social and cultural norms. So, ...
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P60TRP improves cognitive functions in mice. Results obtained from twoday RAWM testing in p60TRP transgenic mice as described in supplemental Materials and methods. Data were collected from three-months-old p60TRP transgenic mice and wild-type littermates. Each block consists of four trials. Average error committed by p60TRP transgenic mice for each trial block. The data shown were obtained from female p60TRP transgenic mouse line-1 (S1 38) (diamond, n 8) and wild-type littermates (squares, n 8) (A). Average error of male mice for each trial block. The data shown were obtained from p60TRP transgenic mouse line-1 (S1) (diamond, n 10) and wildtype littermates (squares, n 10) (B). Average error of male and female mice for each trial block. The data shown were obtained from p60TRP transgenic mouse line-1 (S1) (diamond, n 12) and wildtype littermates (squares, n 12) (C). Average error of male and female mice for each trial block. The data shown were obtained from the p60TRP transgenic ...
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