Caruso, Denise A, Orme, Lisa M, Neale, Alana M, Radcliff, Fiona J, Amor, Gerlinda M, Maixner, Wirginia, Downie, Peter, Hassall, Timothy E, Tang, Mimi LK and Ashley, David M 2004, Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer, Neuro-oncology, vol. 6, no. 3, pp. 236-246, doi: 10.1215/S1152851703000668. ...
0110] The following references, to the extent that they provide exemplary procedural or other details supplementary to those set forth herein, are specifically incorporated herein by reference. [0111] U.S. Pat. No. 5,922,591 [0112] U.S. Pat. No. 5,921,396 [0113] U.S. Pat. No. 5,726,012 [0114] U.S. Pat. No. 5,090,420 [0115] Allewell, N. M., Sama, A., "The effect of ammonium sulfate on the activity of ribonuclease A." Biochemica et Biophysica Acta 341:484-488 (1974). [0116] Auffray, C., Rougeon, F., "Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA." Eur. J. Biochemistry June;107(2)303-314 (1980). [0117] Boom, W. R., Adriaanse, H., Kievits, T., Lens, P. F., U. S. Pat. No. 5,234,809 entitled: Process for Isolating Nucleic Acid. [0118] Bugos R. C., Chiang, V. L., Zhang, X. H., Campbell, E. R., Podila G. K., Campbell W. H., "RNA isolation from plant tissues recalcitrant to extraction by guanidine." Biotechniques November;19(5)734-7 (1995). [0119] Cairns, M. ...
In another study titled "See the Change," researchers at the Genomic Research Institute have been working on a method called "liquid biopsy" through which better diagnosis and monitoring of the DIPG tumor can be made possible. It can also help track DIPG in real time and measure the impact of treatment on the tumor much before MRI scans can.. A research, supported by Michigan Medicines Pediatric Brain Tumor Research Initiative found that a gene mutation known as PTEN plays an important role in DIPGs course in the brain stem. Targetting PTEN may be the path to finding a cure.. Scientists at the Feinberg School of Medicine of Northwestern University have found a molecule that could stop the development of DIPG. "BET bromodomain inhibitor," the molecule used in this study, was effective in stopping the growth of the tumor. More trials are yet to be done to prove its efficacy.. The "BRAVO trial" where the clinical effects of a personalized dendritic cell vaccine made from the persons tumor RNA ...
Thus far Ive discussed various methods we use to diagnose dogs with osteosarcoma and the staging tests for canine osteosarcoma. In the following two articles I will describe palliative and definitive treatment options for this disease, and their respective prognoses. To review, osteosarcoma is an aggressive form of bone cancer in dogs. Most tumors arise…