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Stimulation of the Ras pathway results in the activation of ERK and RSK, but the precise mechanisms involved in RSK activation and inactivation remain elusive. In this study, we characterized the ERK binding domain of RSK1 and found that a serine residue located near the docking site (position 749 in avian RSK1) was involved in the regulation of ERK1/2 binding (Fig. 1 to 3). We also found that Ser749 was efficiently phosphorylated by the RSK1 N-terminal kinase domain in vitro (Fig. 4) and that mutations in the RSK1 kinase domains disrupted ERK dissociation (Fig. 5). Analysis of different RSK isoforms revealed that RSK1 and RSK2 activation induced ERK1/2 release but that mitogen stimulation did not affect the interaction of ERK1/2 with RSK3 (Fig. 6). We also found that RSK3 remains activated longer than RSK1 and RSK2 (Fig. 7), indicating that ERK association promotes RSK activation or antagonizes RSK inactivation.. Our results indicate that the minimal region in RSK1 necessary for ERK1/2 docking ...
16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, RNA (5-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3), tRNA-Gln, tRNA-Met, tRNA-Gln, capreomycin IA, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 23S ribosomal RNA, 5S ribosomal RNA, ...
canSAR Cell Line Evidence of Q5SLP8 | rpsF | 30S ribosomal protein S6 - Also known as RS6_THET8, rpsF. Located on the outer edge of the platform on the body of the 30S subunit. Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S18. May make transient contacts with protein L2 of the 50S subunit during translation.
casSAR Dugability of A4FWE8 | rps10 | 30S ribosomal protein S10 - Also known as RS10_METM5, rps10. Involved in the binding of tRNA to the ribosomes. Part of the 30S ribosomal subunit.
casSAR Dugability of A6U858 | rpsJ | 30S ribosomal protein S10 - Also known as RS10_SINMW, rpsJ. Involved in the binding of tRNA to the ribosomes. Part of the 30S ribosomal subunit.
In LANCE Ultra kinase assays, the binding of a Eu-labeled anti-phosphosubstrate antibody to the phosphorylated ULight-labeled substrate brings donor and acceptor molecules into close proximity. After irradiation of the kinase reaction at 320 or 340 nm, the energy from the Eu donor is transferred to the ULight acceptor dye, which in turn generates light at 665 nm. The intensity of the light emission is proportional to the level of ULight-substrate phosphorylation.. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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Aret-Stav s.r.o. - in en rsk s t ,zemn protlaky,stavebn pr ce, i t n kanalizace,demont parovodu,plynovodu,d lkovodu,rozvod a jejich likvidace.
Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase. Serine/Threonine Kinases (STKs), 70 kDa ribosomal protein S6 kinase (p70S6K) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate ...
One of the Y-linked copies of the ribosomal protein S4 is expressed during spermatogenesis and germ cell development and the C-terminus of the protein has some degree of functional specialisation of this protein in spermatogenesis ...
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008 ...
cytosol, cytosolic small ribosomal subunit, extracellular exosome, extracellular matrix, focal adhesion, membrane, nucleoplasm, small ribosomal subunit, RNA binding, structural constituent of ribosome
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
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... , AS16 3832, Q2F981; LOC_Osm1g00310.1, Ribosomal protein small subunit 2.
... , AS16 3835, Q2F963; LOC_Osm1g00500.1, Ribosomal protein small subunit 1.
mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia. - María Dolores Pastor, Isaac García-Yébenes, Noelia Fradejas, José Manuel Pérez-Ortiz, Silvia Mora-Lee, Pedro Tranque, María Angeles Moro, Mario Pende, Soledad Calvo
modification of the common fold; contains extra alpha-beta unit after strand 2, the extra strand is inserted between strands 3 and 4 ...
90-kDa Ribosomal Protein S6 Kinases: A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Phosphorylation of the C terminus of c-Fos has been implicated in serum response element-mediated repression of c-fos transcription after its induction by serum growth factors. The growth-regulated enzymes responsible for this phosphorylation in early G1 phase of the cell cycle and the sites of phosphorylation have not been identified. We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. The major phosphopeptides derived from biosynthetically labeled c-Fos correspond to phosphopeptides generated after phosphorylation of c-Fos in vitro with both RSK and MAP kinase. The phosphorylation sites identified for RSK (Ser-362) and MAP kinase (Ser-374) are in the transrepression domain. Cooperative phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the ...
To measure 40S ribosome biogenesis, we analyzed either nascent ribosomal proteins or ribosomal RNA (rRNA) in the livers of IFN-α-treated mice that were fasted and then refed for 3 hours in the presence of 35S-methionine or inorganic phosphate-32 (32Pi). Staining of ribosomal proteins (Fig. 2C) or rRNA (Fig. 2D) from livers of fS6/CRE+ and fS6/CRE− mice showed no difference in their steady-state levels. In both fS6/CRE+ and fS6/CRE− mice, increased phosphorylation of S6 was detected, as measured by its decreased mobility in both dimensions of electrophoresis (insets, Fig. 2C) (16). However, no newly synthesized35S-labeled 40S ribosomal proteins (Fig. 2C) nor32P-labeled 18S rRNA (Fig. 2D) were detected in livers of fS6/CRE+ mice. In addition, an rRNA species of 34S accumulated in the livers of fS6/CRE+ mice, most likely representing the 34S precursor of 18S rRNA (17). There was no difference in the production of 60S proteins (Fig. 2C) or 28S rRNA (Fig. 2D) in livers of fS6/CRE+ or ...
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of ...
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of ...
Additional details of experimental procedures are included in Supplemental Methods.. Generation of mouse anti-phospho-SENP2-T368. A peptide corresponding to the aa sequence from 358 to 378 of mouse SENP2 (Biotin-NPEGQ-DRRTEDLFEFT*EDMEKEISNA) was synthesized (Peptibody Inc.) with an aminoterminus biotin label in both phosphorylated and unphosphorylated forms. A mouse anti-phospho-SENP2-T368 single-chain Fv (scFv) was generated against the phospho-peptide by phage display (22) with a naive human phage display library constructed from peripheral blood lymphocytes (23, 24).. Isolation of MECs. MECs were isolated according to our previous publication (1).. Cell culture and flow apparatus. HUVECs were obtained from collagenase-digested umbilical cord veins (25) and collected in M200 medium supplemented with LSGS (Cascade Biologic) and 5% fetal bovine serum (Hyclone). HUVECs were cultured on 0.2% gelatin-precoated dishes. Cells were used for experiments at passages 4 and 5. To expose the cells to flow ...
Ribosomal protein S6 kinase 1 (S6K1), a critical mediator of cell growth, is overexpressed in breast cancer and is associated with poor prognosis. S6K1 has two known isoforms, p85(S6K1) and p70(S6K1). p85(S6K1) is characterized by 23 additional amino acids in the N-terminus of p70(S6K1). This is tho …
Shop Probable 60S ribosomal protein ELISA Kit, Recombinant Protein and Probable 60S ribosomal protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Recombinant Ribosomal Protein S16 (RPS16) Protein (His tag). Species: Mouse (Murine). Source: Escherichia coli (E. coli). Order product ABIN3132967.
SWISS-MODEL Repository entry for A0A0K2I1G4 (A0A0K2I1G4_MYCBI), 30S ribosomal protein S4. Mycobacterium tuberculosis variant bovis BCG
SWISS-MODEL Repository entry for A1S240 (RS13_SHEAM), 30S ribosomal protein S13. Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
This model describes the bacterial and organellar branch of the ribosomal protein S7 family (includes prokaroytic S7 and eukaryotic S5). The eukaryotic and archaeal branch is described by model TIGR01028 ...
K02945 RP-S1; small subunit ribosomal protein S1 K02967 RP-S2; small subunit ribosomal protein S2 K02982 RP-S3; small subunit ribosomal protein S3 K02986 RP-S4; small subunit ribosomal protein S4 K02988 RP-S5; small subunit ribosomal protein S5 K02990 RP-S6; small subunit ribosomal protein S6 K02992 RP-S7; small subunit ribosomal protein S7 K02994 RP-S8; small subunit ribosomal protein S8 K02996 RP-S9; small subunit ribosomal protein S9 K02946 RP-S10; small subunit ribosomal protein S10 K02948 RP-S11; small subunit ribosomal protein S11 K02950 RP-S12; small subunit ribosomal protein S12 K02952 RP-S13; small subunit ribosomal protein S13 K02954 RP-S14; small subunit ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 K02956 RP-S15; small subunit ribosomal protein S15 K02959 RP-S16; small subunit ribosomal protein S16 K02961 RP-S17; small subunit ribosomal protein S17 K02963 RP-S18; small subunit ribosomal protein S18 K02965 RP-S19; small subunit ribosomal protein S19 K02968 ...
Clone REA420 recognizes the human 40S ribosomal protein S6 antigen phosphorylated at serine 240 (pS240). Ribosomal protein S6 is one of 33 proteins that comprise the 40 S ribosomal subunit and becomes phosphorylated at several serine residues upon mitogen stimulation. It plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Activation of the p90 ribosomal S6 kinases (RSKs) by serum, growth factors, tumor promoting phorbol esters, and oncogenic Ras is required for ribosomal protein S6 phosphorylation downstream of the Ras/ERK signaling cascade. The phosphorylation sites in ribosomal protein S6 have been mapped to five clustered serine residues - S235, S236, S240, S244, and S247 - which are located at the C terminus and are conserved from Drosophila to mammals. Additional information: Clone REA420 displays negligible binding to Fc receptors. - Österreich
Clone REA420 recognizes the human 40S ribosomal protein S6 antigen phosphorylated at serine 240 (pS240). Ribosomal protein S6 is one of 33 proteins that comprise the 40 S ribosomal subunit and becomes phosphorylated at several serine residues upon mitogen stimulation. It plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Activation of the p90 ribosomal S6 kinases (RSKs) by serum, growth factors, tumor promoting phorbol esters, and oncogenic Ras is required for ribosomal protein S6 phosphorylation downstream of the Ras/ERK signaling cascade. The phosphorylation sites in ribosomal protein S6 have been mapped to five clustered serine residues - S235, S236, S240, S244, and S247 - which are located at the C terminus and are conserved from Drosophila to mammals. Additional information: Clone REA420 displays negligible binding to Fc receptors. - USA
Ribosomal Protein S23 antibody LS-C268553 is an APC-conjugated rabbit polyclonal antibody to human Ribosomal Protein S23 (RPS23 ). Validated for ELISA and WB.
The SCOP classification for the Ribosomal protein S6 superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
The SCOP classification for the Ribosomal protein S20 superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
The SCOP classification for the Ribosomal protein S2 superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
RPS6 antibody for detecting human 40S ribosomal protein S6. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
We have been focused on the ribosome as one plausible vehicle for front-loading evolution. This hypothesis led us to successfully expect ribosomal proteins would carry out additional functions and that some portions of the ribosomal RNA might actually code for protein. So its time to dig a little deeper. I recently noted that the small…
Rabbit Polyclonal Anti-Ribosomal Protein S29 Antibody. Validated: WB, IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
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http://www.india-forums.com/tellybuzz/wassup/8079-sharmi-fails-in-the-pavitrata-test-in-ganga-kii-dheej.htm Sharmi fails the Pavitara Test in Ganga Ki Dheej... Tuesday, November 16, 2010 | 6:09:52 PM IST (+05:30 GMT) 29 Comments Tonights episode of Sahara Ones Ganga Kii dheej ... | Page: 2 | 1568176 | Ganga Kii Dheej Forum
K02945 RP-S1; small subunit ribosomal protein S1 K02967 RP-S2; small subunit ribosomal protein S2 K02982 RP-S3; small subunit ribosomal protein S3 K02986 RP-S4; small subunit ribosomal protein S4 K02988 RP-S5; small subunit ribosomal protein S5 K02990 RP-S6; small subunit ribosomal protein S6 K02992 RP-S7; small subunit ribosomal protein S7 K02994 RP-S8; small subunit ribosomal protein S8 K02996 RP-S9; small subunit ribosomal protein S9 K02946 RP-S10; small subunit ribosomal protein S10 K02948 RP-S11; small subunit ribosomal protein S11 K02950 RP-S12; small subunit ribosomal protein S12 K02952 RP-S13; small subunit ribosomal protein S13 K02954 RP-S14; small subunit ribosomal protein S14 K02956 RP-S15; small subunit ribosomal protein S15 K02959 RP-S16; small subunit ribosomal protein S16 K02961 RP-S17; small subunit ribosomal protein S17 K02963 RP-S18; small subunit ribosomal protein S18 K02965 RP-S19; small subunit ribosomal protein S19 K02968 RP-S20; small subunit ribosomal protein S20 K02970 ...