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Volume 21, Issue 1, pages 42-52, January 2014. Original Article. U. Mihm1,†, M.-W. Welker1,†, G. Teuber2, H. Wedemeyer3, T. Berg4, C. Sarrazin1, S. Böhm4, U. Alshuth5, E. Herrmann6, S. Zeuzem1,*. Article first published online: 21 JUN 2013. DOI: 10.1111/jvh.12124. © 2013 John Wiley & Sons Ltd. Abstract. Keywords: IL28B genotype; ribavirin monotherapy; ribavirin priming; viral kinetics. Summary. Ribavirin amplifies the interferon-alpha (IFN) signalling cascade. As ribavirin needs 4 weeks to reach steady state, ribavirin priming may optimize hepatic IFN sensitivity before starting a pegylated (PEG)-IFN/ribavirin combination therapy. This study investigated potential benefits of ribavirin priming prior to PEG-IFN2a/ribavirin combination therapy on viral kinetics, on-treatment and sustained virological response (SVR) in chronic hepatitis C virus (HCV) genotype 1 infection. Sixty-eight treatment naive patients were randomized 2:2:1 to ribavirin (ribavirin arm) or placebo (placebo arm) or ...
Aim: Elevation of alanine aminotransferase (ALT) levels during pegylated-interferon (peg-IFN) plus ribavirin therapy in patients with chronic hepatitis C [CHC] is a problem that cannot be disregarded. The aim of this study is to assess the frequency and to characterize clinical parameters of this phenomenon.. Methods: Two hundred and thirty-five (235) CHC patients with genotype 1b receiving peg-IFN α-2b plus ribavirin therapy were analyzed. Clinical parameters that may be associated with abnormal ALT values during treatment and therapy outcomes were evaluated statistically. One hundred and sixteen (116) patients treated with peg-IFN α-2a plus ribavirin were also included for partial analysis.. Results: Abnormal ALT values during treatment were observed in 23.0% of patients. It was observed in 14.5% of those with sustained virological response (SVR) and 17.8% of those with relapse, in whom viral clearance was observed during therapy. Multivariate logistic regression analysis revealed that ...
Objectives: 1. Primary objective: To Evaluate the rate of sustained virological response (SVR) of pegylated interferon alfa-2b (Peg-IFN) plus ribavirin (RBV) plus nitazoxanide (NTZ) in patients coinfected by HIV and HCV genotype 4 (HCV-4), never treated before (naïve) and with a treatment failure to a standard therapy with Peg-IFN plus RBV (experienced), and to compare it with the rate of SVR of these patients with Peg-IFN plus RBV is a historical cohort. 2. Secondary objectives: In naive, as well as in experienced patients: a) To evaluate the virological activity at weeks 4 and 12 after starting the combination of Peg-IFN plus RBV plus NTZ in HIV/HCV-4-coinfected patients. b) To analyze the safety of Peg-IFN plus RBV plus NTZ in HIV/HCV-4-coinfected patients.. Design: Pilot clinical trial without control to evaluate efficacy and safety (phase II).. Patients: Individuals with HIV infection and with confirmed chronic HCV infection.. Treatment: NTZ 500 mg every 12 hours during 4 weeks, followed ...
Objectives: 1. Primary objective: To Evaluate the rate of sustained virological response (SVR) of pegylated interferon alfa-2b (Peg-IFN) plus ribavirin (RBV) plus nitazoxanide (NTZ) in patients coinfected by HIV and HCV genotype 4 (HCV-4), never treated before (naïve) and with a treatment failure to a standard therapy with Peg-IFN plus RBV (experienced), and to compare it with the rate of SVR of these patients with Peg-IFN plus RBV is a historical cohort. 2. Secondary objectives: In naive, as well as in experienced patients: a) To evaluate the virological activity at weeks 4 and 12 after starting the combination of Peg-IFN plus RBV plus NTZ in HIV/HCV-4-coinfected patients. b) To analyze the safety of Peg-IFN plus RBV plus NTZ in HIV/HCV-4-coinfected patients.. Design: Pilot clinical trial without control to evaluate efficacy and safety (phase II).. Patients: Individuals with HIV infection and with confirmed chronic HCV infection.. Treatment: NTZ 500 mg every 12 hours during 4 weeks, followed ...
This study investigated the effect of pegylated interferon (alfa 2a and alfa 2b) plus ribavirin in chronic hepatitis C patients with mixed genotype 1 and 2.
Editorial note from Jules Levin: This study examines giving a reduced dose of PegIntron with a fixed dose of 800 mg of ribavirin to coinfected patients. Interferon and ribavirin may be difficult to tolerate and have toxicity for some HIV infected patients as studies in coinfected patients often have greater discontinuation rates. Therefore, this study is important in that it examines providing a reduced dose of peginterferon plus only 800 mg of ribavirin. The results are interesting and significant for real world clinic settings. The study results suggest you can start therapy with full dose of peginterferon and if after a few months the patient wants to discontinue therapy due to the side effects you can reduce the interferon and ribavirin doses and still see a reasonable viral response to therapy ...
BACKGROUND Data are limited on the efficacy and safety of pegylated interferon plus ribavirin for patients with hepatitis C virus genotype 1 (HCV-1) receiving hemodialysis. OBJECTIVE To compare the efficacy and safety of combination therapy with pegylated interferon plus low-dose ribavirin and pegylated interferon monotherapy for treatment-naive patients with HCV-1 receiving hemodialysis. DESIGN Open-label, randomized, controlled trial. (ClinicalTrials.gov: NCT00491244). SETTING 8 centers in Taiwan. PATIENTS 205 treatment-naive patients with HCV-1 receiving hemodialysis. INTERVENTION 48 weeks of pegylated interferon-α2a, 135 µg weekly, plus ribavirin, 200 mg daily (n = 103), or pegylated interferon-α2a, 135 µg weekly (n = 102). MEASUREMENTS Sustained virologic response rate and adverse event-related withdrawal rate. RESULTS Compared with monotherapy, combination therapy had a greater sustained virologic response rate (64% vs. 33%; relative risk, 1.92 [95% CI, 1.41 to 2.62]; P | 0.001).
Abnormal serum lipid profiles have been noted in patients with chronic hepatitis C virus (HCV) infection. Moreover, many reports suggest that serum lipoprot ...
Dear Editor: Recently, the standard of care (SoC) of chronic hepatitis C virus (HCV) infection has changed, and HCV treatment has entered a new era with the.. Modelling hepatitis C therapy-predicting effects of treatment. of Peg-IFN and ribavirin therapy for hepatitis C. a hepatitis C. Aug.Un nuevo medicamento para la hepatitis C mostró sus primeros resultados positivos en pacientes infectados tanto por esta enfermedad como por el. el ribavirin. El.17 Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in hepatitis C., 2012; 11 (1): 15-31 Study design Patients eligible for this phase 2 double-blind.INFORME ANUAL DE AUTOEVALUACION DEL DIRECTOR GENERAL 2011 6 Huerta Yépez S., Baay Guzman, Bebenek I. G., Hernández Pando R. Vega M, Chi L., Riedl.hepatitis virus B, C IFNa and ribavirin Orthomyxoviren influenza A, B Paramyxovirus. ribavirin Orthomyxoviren.. c) side effects and. et al. Efficacy and safety of aerosolized ribavirin in young. 91. Van Voris LP. Antivirals for the chemoprophylaxis ...
Standard treatment for chronic hepatitis C is with interferon (IFN)-α and ribavirin for 6-12 months. In dialysis patients only interferon therapy is currently used due to the lack of knowledge concerning ribavirin dosage and side-effects. The aim of this study was to investigate if ribavirin can be added to interferon when treating dialysis patients with hepatitis C.. Five patients on haemodialysis and one patient on peritoneal dialysis with chronic hepatitis C, five with genotype 1 and one with genotype 4, were given interferon-α2b 3 MU thrice weekly for 4 weeks, whereafter ribavirin 200-400 mg was added, for an intended total treatment period of 28 weeks. Ribavirin plasma concentrations were monitored, using HPLC.. Four patients completed the treatment. One patient suffered marked side-effects from interferon and therapy was terminated. One patient developed heart failure and died after 14 weeks of treatment but the death was not considered treatment related. Based on plasma concentrations, ...
In this study, we demonstrate that ribavirin inhibits the viral replication of SFTSV in Vero cells in a dose-dependent manner. The IC50 of ribavirin against SFTSV ranged from 3.69 to 8.72 μg/mL, which is similar to that for Andes virus (5 to 12.5 μg/mL) and Lassa virus (9 to 20 μg/mL), but substantially lower than that for Rift Valley fever virus (40 to 80 μg/mL) [5,6]. Our results suggest that ribavirin may be used as an antiviral agent for patients with SFTSV infection.. Our study clearly showed that treatment with ribavirin concentrations of ≥ 8 μg/mL significantly reduced viral RNA titers in vitro. A recent study by Shimojima at al. [10] also reported that SFTS viral production in Vero, Huh7, and U2OS cells was reduced by 99% at ribavirin concentrations of 64, 20, and 19 μg/mL, respectively. The actual concentrations of ribavirin showing antiviral effects in other cell lines might be lower than that of Vero cells, which are known to be more resistant to ribavirin [11].. The present ...
The recognition of early predictors of a lack of sustained response in HIV-infected patients receiving peg-IFN plus ribavirin may allow the earlier discontinuation of a medication that will not provide benefit while frequently being associated with side-effects, is expensive, reduces the patients quality of life, and as stated earlier, may be harmful because of interactions between ribavirin and HIV nucleoside analogues. No data are available so far on the best time for discontinuing therapy in HIV/HCV-co-infected patients receiving peg-IFN plus ribavirin. In our trial, we specifically examined whether the recognition of negative serum HCV-RNA levels at different timepoints could be used for early therapy-off decision-making. The time to the first negative serum HCV-RNA levels among subjects who later achieved sustained responses was one month in 72% of cases, and 3 months in 88%. However, three of the 27 subjects (11.1%) who finally reached sustained response cleared HCV-RNA after the third ...
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Under-enrolment of women to randomized clinical trials, including chronic hepatitis C, has long been recognized. The aim of this study was to identify factors predictive of sustained virological response (SVR) to PEG IFN/Ribavirin antiviral therapy in relation to gender and reproductive status of female patients involved. Seven hundred and forty-six treatment-naïve patients (431 men, 315 women) treated with Peg-IFNα-2a (180 μg/week) or Peg-IFNα-2b (1.5 μg/kg/week) plus ribavirin (800-1400 mg/day) for 24 or 48 weeks were studied between 2006 and 2010. Differences in SVR rate, overall and by gender were assessed after adjustment and propensity score matching. SVR was obtained in 44.2% of Peg-IFNα-2a-treated patients and in 51.2% of Peg-IFNα-2b-treated patients (intention-to-treat; P = 0.139). Age, fibrosis stage and genotype 2 and 3 were independently associated with SVR by multivariate analysis. Analysing by gender, the difference in SVR between PEG-IFNα types was not significant in men ...
TY - JOUR. T1 - Cytogenetic effects of ribavirin on mouse bone marrow. AU - Seetharama Rao, K. P.. AU - Abdul Rahiman, M.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The micronucleus test and mitotic chromosome analysis were used to study the in vivo mutagenic activity of ribavirin on bone marrow cells of Swiss albino mice. To determine the incidence of micronuclei, mice were injected i.p. twice, at an interval of 24 h, with the drug at doses of 20, 100 and 200 mg/kg. Animals were killed 6 h after the second dose and bone marrow was examined for the presence of micronuclei in developing erythrocytes. Ribavirin significantly (P , 0.05) induced micronuclei in polychromatic erythrocytes at all doses. A study was conducted to investigate the cytogenetic effect of the drug on mitotic chromosomes. Ribavirin at 200 mg/kg/day was administered to mice for 3 and 5 days. Repeated treatment with the high dose of ribavirin produced a highly significant (P , 0.02) increase in abnormal metaphase spreads. The results ...
Claimed and disclosed is a new use for a previously approved drug: erythropoietin. The present invention teaches using Erythropoetin to treat anemia caused by the combined treatment of Ribavirin and alpha-interferon. Erythropoetin has previously been approved for the treatment of anemia caused by cancer chemotherapy, renal failure and HIV. It has not been used for anemia caused by ribavirin. Ribavirin is part of a two-drug regimen now used to treat hepatitis C along with alpha interferon. The principal side effect of ribavirin is a hemolytic anemia. In the past, mangement of that anemia was done by dose reduction of the ribavirin, sometimes resulting in reversal of part of the anemia. It has become particularly important in light of new data, to maximize the dose of ribavirin given to persons undergoing treatment for hepatitis C to ensure a successful eradication of hepatitis C.
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This study suggests that the kinetics of proteome are significantly different in serum of patients according to treatment response. Serum protein profiling allows prediction of response to antiviral treatment in a significant proportion of patients.
Our data suggest that the efficacy of peginterferon and ribavirin therapy in Koreans is better in Koreans than in Caucasians for the treatment of CHC, corroborating previous studies that have shown the superior therapeutic efficacy of this regimen in Asians.
Background: The recommended treatment for patients infected with hepatitis C virus genotype 2 (HCV2) is pegylated interferon (peginterferon) and ribavirin for 24 weeks.. Aim: To assess whether a shorter 16-week treatment is as effective as a standard 24-week treatment.. Methods: Patients with HCV2 infection were randomised in a 1:2 ratio to either 16 weeks (n = 50) or 24 weeks (n = 100) of treatment with peginterferon α-2a (180 μg/week) and weight-based ribavirin 1000-1200 mg/day, with a 24-week follow-up period. A rapid virological response (RVR) was defined as seronegative for HCV RNA at 4 weeks of treatment, and the primary end point, sustained virological response (SVR), as seronegative for HCV RNA at the 24-week follow-up.. Results: The rate of RVR and SVR was 86% (43/50, 95% confidence interval (CI) 76% to 96%) and 94% (47/50, CI 87% to 100%), respectively, in the 16-week group, which was comparable to 87% (87/100, CI 80% to 94%) and 95% (95/100, CI 91% to 99%) in the 24-week group. ...
BACKGROUND: Efficacy, safety and pharmacokinetics of simeprevir (TMC435), a once-daily, noncovalent, oral hepatitis C virus (HCV) NS3/4A protease inhibitor, was evaluated in combination with peginterferon α-2a/ribavirin (PegIFNα-2a/RBV) for treatment-naïve, HCV genotype 1-infected patients in Japan. METHODS: In a multicenter, randomized clinical trial in Japan, ninety-two patients received either simeprevir (50 or 100 mg QD) for 12 or 24 weeks with PegIFNα-2a/RBV for 24 or 48 weeks (according to response-guided therapy [RGT] criteria), or PegIFNα-2a/RBV for 48 weeks (PR48 group). RESULTS: Compared with the PR48 group, plasma HCV RNA reductions in the simeprevir groups were rapid and more substantial (Week 4: -5.2, -5.2 and -2.9 log10IU/mL for simeprevir 50 mg combined, 100 mg combined, and PR48 groups, respectively). High rapid virologic response rates (83, 90, and 8 % for simeprevir 50 mg combined, 100 mg combined, and PR48 groups, respectively) led to high sustained virologic response ...
A study of patients with chronic hepatitis C and a history of hepatocellular carcinoma treated with pegylated interferon alpha-2b plus ribavirin showed a high risk of recurrence, according to data presented at IDWeek 2012.
ClinicalTrials.gov summary of Pioglitazone Before Peginterferon and Ribavirin for Hepatitis C Infection in HIV/HCV-Coinfected Patients With Insulin Resistance
Treatment of chronic hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin improves the rate of eradication of HCV, but only about 13-14% of non-responders (NR) with HCV of genotype 1b previously treated with IFN achieve a sustained virological response (SVR). To determine whether HCV quasispecies diversity correlates with the outcome of therapy with IFN and ribavirin, we studied 13 patients undergoing combination therapy with IFN-alpha2b and ribavirin after failure of IFN monotherapy. HCV quasispecies diversity was assessed by cloning and sequencing before and during combination therapy. During therapy, quasispecies diversity diminished in NR patients, both in the hypervariable region (HVR) 1 of the envelope 2 (E2) domain and in the interferon sensitivity-determining region (ISDR) in the NS5A. Pre-treatment nucleotide quasispecies diversity was lower in SVR and end-of-therapy viral response (ETR) patients than in NR patients. Resistance to ribavirin was associated with high pre
Lancet. 2001 Sep 22;358(9286):958-65. Clinical Trial; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S.
Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin, Academic Article ...
Background and Aims: Having a body mass index above or equal to 30 kg/m2 in conjunction with chronic hepatitis C virus infection is associated with non-responsiveness to treatment with interferon and ribavirin, but details regarding the mechanisms whereby obesity reduces the efficacy of therapy remain unclear.. Methods: This study evaluated impact of obesity on outcome as well as interferon and ribavirin concentrations following standard-of-care fixed dosing with peginterferon-α2a 180 µg once weekly and ribavirin 800 mg daily among 303 HCV genotype 2/3-infected patients enrolled in the per-protocol analysis of a recently completed phase III trial (NORDynamIC).. Results: Patients with BMI ≥30 kg/m2 showed poorer outcome following 24 weeks of therapy (SVR 62% vs. 89% for BMI ≥30 vs. ,30; P = 0.006) along with significantly higher steatosis grade (P = 0.002), HOMA-IR (P,0.0001), triglyceride levels (P = 0.0002), and baseline viral load (P = 0.028). Obesity was also significantly associated ...
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants. To explore lethal mutagenesis of hepatitis C virus (HCV), it is important to establish whether ribavirin, the purine nucleoside analogue used in anti-HCV therapy, acts as a mutagenic agent during virus replication in cell culture. Here we report the effect of ribavirin during serial passages of HCV in human hepatoma Huh-7.5 cells, regarding viral progeny production and complexity of mutant spectra. Ribavirin produced an increase of mutant spectrum complexity and of the transition types associated with ribavirin mutagenesis, resulting in HCV extinction. Ribavirin-mediated depletion of intracellular GTP was not the major contributory factor to mutagenesis since mycophenolic acid evoked a similar decrease in GTP without an increase in mutant spectrum ...
Background & Aims:. Sustained response to interferon treatment for chronic Hepatitis C is unsatisfactory, This study examined whether combining interferon alfa with ribavirin induces a better sustained efficacy than interferon alone in the treatment of chronic Hepatitis C.. Methods:. Sixty noncirrhotic patients with chronic Hepatitis C were randomly assigned to three groups, Group 1 received 1200 mg oral ribavirin daily plus 3 million units of recombinant interferon alfa 2a thrice weekly for 24 weeks, group 2 received the same dose of interferon alfa 2a alone for 24 weeks, and group 3 received no treatment, The patients were then followed up for an additional 96 weeks.. ...
Another open question is the optimal duration of peginterferon and ribavirin treatment once a complete virologic response has been induced. When negative HCV RNA levels are not reached before week 24, an extension of treatment to a total of 72 weeks is recommended. Whether successful silibinin rescue at an earlier stage of antiviral treatment (e.g. week 12) would obviate the need for this extended treatment cannot be deducted from our data. While a viral breakthrough was seen in only one patient during continued peginterferon and ribavirin treatments, the relapse rate after end of antiviral treatment was surprisingly high. In conclusion, the very short-term rescue approach with high-dose silibinin infusion has been shown to be effective in partial responder patients with persistent viral replication on peginterferon alpha plus ribavirin therapy. Further studies are needed to clarify whether longer courses of silibinin treatment can provide an advantage and whether silibinin rescue might be of ...
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Hepatology 1998 Aug;28(2):341-346. Sequential versus concomitant administration of ribavirin and interferon alfa-n3 in patients with chronic Hepatitis C not responding to interferon alone: results of a randomized, controlled trial.. Sostegni R, Ghisetti V, Pittaluga F, Marchiaro G, Rocca G, Borghesio E, Rizzetto M, Saracco G. Dipartimento di Gastroenterologia, Ospedale Molinette, Universita di Torino, Italy.. We conducted a three-arm, randomized trial in 96 patients with chronic Hepatitis C who did not respond to interferon alfa to compare treatments. Group 1 (33 patients) received ribavirin alone (1,000 mg/daily for 6 months) followed by interferon alfa n-3 alone (3 MU thrice weekly for 6 months); group 2 (33 patients) received ribavirin plus interferon alfa n-3 for 6 months at the above doses; and group 3 (30 patients) received interferon alfa n-3 alone (3 MU thrice weekly for 6 months). At the end of treatment, 3 patients (10%) in group 1, 13 (41%) in group 2, and 5 (17%) in group 3 had ...
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Anemia is a common adverse event when patients with chronic hepatitis C virus (HCV) receive peginterferon and ribavirin. A decline in the serum hemoglobin by 2 g or more occurs in approximately 75% of these patients and up to 20% have a decline in hemoglobin of more than 4 g.1 In large clinical trials the serum hemoglobin falls below 10 g/dL in approximately 20% of HCV patients during treatment; a decline in the hemoglobin to less than 8.5 g/dL occurs in about 5% of patients receiving peginterferon and ribavirin. Anemia significantly exacerbates the fatigue that many patients experience while ...
This months Journal of Hepatology investigates retreatment with pegylated interferon plus ribavirin of chronic hepatitis C non-responders to interferon plus ribavirin.. ...
BARCELONA, Spain, Apr 19, 2012 (BUSINESS WIRE) --Gilead Sciences, Inc. (Nasdaq:GILD) today announced interim data from a Phase 2 trial (ATOMIC) examining a 12-week course of treatment with the once-daily nucleotide GS-7977 plus pegylated interferon (Peg-IFN) and ribavirin (RBV) in treatment-naïve patients with genotype 1 chronic hepatitis C virus (HCV) infection. The study found that 90 percent of patients (n=47/52, missing data equals failure analysis) achieved a 12-week sustained virologic response (SVR12), defined as maintaining undetectable viral load (HCV RNA ,25 IU/mL) 12 weeks after the completion of therapy. These findings will be presented today during an oral session at the 47th Annual Meeting of the European Association for the Study of the Liver (International Liver Congress 2012) in Barcelona, Spain. "These data suggest that this GS-7977-based regimen could offer most patients with genotype 1 a simple, short, three-month course of treatment with very high cure rates," said Kris ...
Boceprevir inhibits the activity of the NS3/4A serine protease. This protease is essential for viral replication and may be partially responsible for the ability of the hepatitis C virus to evade clearance by the host immune system. The drug is administered orally. Clinical trials have demonstrated that treatment with boceprevir plus pegylated interferon and ribavirin produces higher sustained virological response rates (considered to be equivalent to a cure) than pegylated interferon and ribavirin combination therapy. The final draft guidance recommends boceprevir as an option for the treatment of people with genotype 1 chronic hepatitis C, in combination with peginterferon alfa and ribavirin, in adult patients with compensated liver disease who are previously untreated or in whom previous treatment has failed. ...
Ribavirin is an antiviral medication. Ribavirin must be used together with an interferon alfa product (such as Pegasys, PegIntron, Sylatron, or Intron A) to treat chronic hepatitis C. Ribavirin may also be used for purposes not listed in this medication guide.
Traditional therapies for Hepatitis C Virus (HCV) often yield unsatisfactory results. The reason for this may lie in the mechanism of drug resistance of the HCV virus. Despite doing a plain vanilla comparison between the treated and untreated groups, this paper takes a detour and investigates the drug resistance mechanism to interferon plus ribavirin combined therapy by comparing pretreatment sequence data between response and non-response patients in the NS5A region for genotype 1a HCV virus. We use Bayesian probabilistic models to detect single mutation or mutation combinations, and infer interaction structures between these mutations, to investigate the drug resistance combinations differences between those patients. We hope to decipher, at least partially, the reason behind the unsatisfactory results received from interferon plus ribavirin therapy. Author Summary: HCV treatment results have been historically suboptimal[1-3]. HCV drug resistance, which further hinders the treatment effects, is
Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C.: HCV RNA ISDR type is an important factor for predicti
This trial assessed the efficacy and safety of peginterferon alfa-2a (Pegasys) plus ribavirin (Copegus) in Iranian thalassemic patients with chronic hepatitis C
Patients receiving therapy for chronic hepatitis C virus (HCV) infection frequently experience cytopenias and weight loss. We retrospectively assessed the pharmacodynamic effects of pegylated interferon (PEG-IFN) alfa-2a and ribavirin by evaluating the relationship between changes in hematologic parameters, body weight, and virologic response. Patients with HCV genotypes 1, 4, 5, or 6 receiving 24 or 48 weeks of PEG-IFN alfa-2a and ribavirin therapy were pooled from four phase 3/4 trials. Maximum decreases in hemoglobin level, neutrophil count, platelet count, and weight during therapy were assessed according to virologic response category (sustained virologic response [SVR], relapse, breakthrough, and nonresponder) and race/ethnicity. Of 1,778 patients analyzed, more than half were male, non-Hispanic Caucasian, and infected with HCV genotype 1; had a baseline HCV RNA ,800,000; and had alanine aminotransferase levels ≤3 × the upper limit of normal. Virologic responders (SVR, relapse, and ...
Combination therapy. Technivie must be taken in combination with ribavirin, so all of the warnings that apply to ribavirin also apply to people considering Technivie. For more information on ribavirin, see the ribavirin factsheet.. Pregnancy Ribavirin can harm a fetus and the drugs in Technivie have not been tested in people who are pregnant, so these medications should not be taken by anyone who is pregnant. Talk to your doctor if you are pregnant or thinking about having a baby.. People on hepatitis C treatment who could get pregnant or who are sex partners with someone who could get pregnant should use two forms of reliable contraception.. Breastfeeding/nursing. People with infants who are taking Technivie should not breastfeed or nurse their children.. Hepatitis B The U.S. Food and Drug Administration (FDA) recommends that all people starting hepatitis C treatment with DAA medications be tested for hepatitis B before starting treatment.. This is because if someone has hepatitis C and ...
This study highlights the experiences of 21 HCV patients who completed treatment with PEG/RBV for hepatitis C in Taiwan. Participants reported being worried about beginning therapy; they thought it would be impossible to endure and were extremely afraid. However, adopting proactive strategies to confront the adverse effects of HCV therapy helped them endure the 24-48 weeks of treatment. Several approaches were utilized: restructuring of lifestyle, adopting a positive attitude, and seeking support. To our knowledge, this is the first time an application of these strategies has been described for HCV patients in an Eastern country.. The standard treatment strategy was based on the therapy of PEG/RBV for HCV patients, which was the only therapy available until 2011. The recent appearance of DAAs has changed HCV therapy. The new treatments offer all-oral regimens, short duration of therapy (from 6-12 weeks to 24-48 weeks), few side effects, and high cure rates (,90 %) [28]. However, use of these new ...
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Well-known statin could be recycled as HCV therapy supplement. New data presented today at the International Liver CongressTM confirm the antiviral activity of fluvastatin -- commonly used as a cholesterol-lowering treatment -- in patients with chronic hepatitis C (HCV).. Patients had improved early and sustained virological response (EVR and SVR) when treated with the current standard of care "" pegylated Interferon-alpha and ribavirin (PegIFNï ¡/RBV) "" and fluvastatin. The results show patients receiving fluvastatin and PegIFNï ¡/RBV achieve higher rates of EVR and SVR "" 75.96% and 63.46% "" to those receiving placebo and PegIFNï ¡/RBV "" 61.9% and 49.52% respectively.. EASLs Secretary General, Professor Heiner Wedemeyer, said: "We know that metabolic syndrome (MS), the main treatment indication for statins, is associated with severe fibrosis and lower treatment responses in chronic HCV patients. The confirmation that the combination of fluvastatin and PegIFNï ¡/RBV ...