AIMS: (1) To assess a range of intravenous immunoglobulin products for atypical classical antineutrophil cytoplasmic antibody (C-ANCA) staining and to determine if this is present in patients treated with high dose intravenous immunoglobulin (2 g/kg/month) and replacement doses (200 mg/kg fortnightly); (2) using the United Kingdom national external quality assessment scheme (NEQAS), to determine if laboratories could differentiate this pattern from classical ANCA. METHODS: ANCA testing was performed on 30 batches of intravenous immunoglobulin from several manufacturers. Six patients treated with high dose intravenous immunoglobulin and 11 receiving replacement doses of immunoglobulin for hypogammaglobulinaemia were tested for ANCA by indirect immunofluorescence on cytospin preparations of ethanol fixed neutrophils and by enzyme linked immunosorbent assay (ELISA). One of the positive immunoglobulin batches was tested blindly by 125 laboratories involved in NEQAS by indirect immunofluorescence and ...
Helpful, trusted answers from doctors: Dr. Parola on low serum globulin levels: Must get on a higher dose of synthroid (thyroxine). This can be life threatening, get treated asap, ! other thyroid tests need to be done to know what needs to be done, and to come to a diagnosis.
TY - JOUR. T1 - Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection. AU - Ogawa, Eiichi. AU - Otaguro, Shigeru. AU - Murata, Masayuki. AU - Kainuma, Mosaburo. AU - Sawayama, Yasunori. AU - Furusyo, Norihiro. AU - Hayashi, Jun. PY - 2008/10. Y1 - 2008/10. N2 - Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. A 39-year-old Japanese woman complained of sudden, severe arthralgia with edematous limbs coincident with an outbreak of HPV-B19 infection at the elementary school attended by her daughter. A diagnosis of acute HPV-B19 infection was made by the detection of serum antibody to HPV-B19 IgM and HPV-B19 DNA. Magnetic resonance imaging revealed bilateral synovitis of the cubital joints. The patient was immunocompetent and suffered from severe arthralgia associated with persistent HPV-B19 viremia for more than 4 months after the diagnosis of acute HPV-B19 infection. ...
RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis.Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis. ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - Pipeline Review, H2 2016, provides an overview of the Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) pipeline landscape. The report provides comprehensive information on the therapeutics under development for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.. Browse more detail information about Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) at: http://www.absolutereports.com/chronic-inflammatory-demyelinating-polyneuropathy-cidp-pipeline-review-h2-2016-10315974. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved ...
Looking for online definition of albumin-globulin (A/G) ratio in the Medical Dictionary? albumin-globulin (A/G) ratio explanation free. What is albumin-globulin (A/G) ratio? Meaning of albumin-globulin (A/G) ratio medical term. What does albumin-globulin (A/G) ratio mean?
Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome. We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks. Unusual neurological presentations in previously fit patients are an appropriate indication for
Autoimmune autonomic ganglionopathy (AAG) is a rare disease that results in severe dysautonomia (disorder of autonomic nervous system function). Many patients are unable to carry out activities of daily living due to autonomic symptoms that do not respond well to therapy (such as drops in blood pressure while standing). The recent discovery of antibodies that cause AAG has stimulated interest in immunomodulatory therapy (therapies that modify the functioning of the immune system). Studies in which a positive clinical response to these therapies have been reported in patients with AAG using immunomodulatory therapy as a treatment.. The investigators plan to carry out a blinded, randomized trial using IVIG. There have been no reported randomized clinical trials with any immunosuppressive agent in AAG. The proposed studies, if successful, will provide the first reliable clinical evidence, that therapy with IVIG is an effective treatment of AAG.. Treatment for the symptoms of autonomic failure is ...
passive vaccination News: Latest and Breaking News on passive vaccination. Explore passive vaccination profile at Times of India for photos, videos and latest news of passive vaccination. Also find news, photos and videos on passive vaccination
The clinical effectiveness and relative ease of administering intravenous immunoglobulin (IVIG) make it the preferred treatment option for several immune mediated conditions including chronic inflammatory demyelinating polyneuropathy (CIDP). Timing and dosage of IVIG vary considerably in CIDP between patients. The cost implications for establishing sensitive and reliable biomarkers, which accurately predict IVIG dosing regimens and avoid overtreatment are therefore considerable and warrant investigation. In this issue, Kuitwaard and colleagues examine the variability of serum IgG levels in patients receiving IVIG for treatment of CIDP.1 They demonstrate … ...
There is uncertainty about the best treatments for two important diseases causing peripheral neuropathy: chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). Consequently, there is a wide treatment variation in practice. Under the leadership of Richard Hughes (London), Eduardo Nobile-Orazio (Milan), and Ivo van Schaik (Amsterdam), 12 experts from 6 European countries assembled at Schiphol Airport, Amsterdam on October 27th to decide on the design of trials to demonstrate the efficacy of drugs in suppressing the immune response and treating these diseases. The group considered all the candidate drugs and chose two for further consideration. Negotiations with pharmaceutical companies will now take place before making the final choice.. The essential elements of the protocols for two randomised trials were debated and agreed upon. The trials will use change in disability as their primary outcome measures. The scales to be used will include a simple ...
Patient information for D-GAM HUMAN ANTI-D IMMUNOGLOBULIN 250 IU SOLUTION FOR INJECTION Including dosage instructions and possible side effects.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a progressive disease leading to paralysis. CIDP is an immune-mediated disorder resulting from a synergistic interaction of T cell-mediated and B cell-mediated immune responses directed against peripheral nerve antigens. These immune mediated responses in turn increase the production of reactive oxygen intermediate and cause oxidative damage of the peripheral nerve system. Although corticosteroids, plasma exchange, and intravenous immunoglobulin (IVIg) reduce impairment caused by CIDP at least temporarily and can be used as a first-line treatments, they are not ideal for long-term treatment because of serious side effects and cost. Alpha lipoic acid (LA) is an antioxidant that also possesses anti-immune activity. It is effective in treating diabetic neuropathy. It is also promising in treating patients with multiple sclerosis ...
Looking for Thyroxine-binding globulin? Find out information about Thyroxine-binding globulin. any of a large family of proteins protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant... Explanation of Thyroxine-binding globulin
TY - JOUR. T1 - Measurement of serum immunoglobulin concentration in killer whales and sea otters by radial immunodiffusion. AU - Taylor, Bernadette C.. AU - Brotheridge, Rory M.. AU - Jessup, David A.. AU - Stott, Jeffrey L. PY - 2002/10/28. Y1 - 2002/10/28. N2 - Killer whales and sea otters maintained in captivity are the subjects of routine health monitoring programs, and interest in immunologic studies in sea otters has been rising recently in response to potential impacts from infectious disease and environmental pollution on the threatened southern sea otter population. Development of species-specific reagents for immunologic studies in these two marine mammals is currently in its infancy. In this study, killer whale and sea otter immunoglobulin-specific polyclonal antibodies were generated, and used to develop tests for serum Ig concentration in the killer whale (Orcinus orca) and the southern (Enhydra lutris nereis) and northern sea otter (Enhydra lutris lutris). Killer whale serum IgG ...
Looking for online definition of fetomaternal hemorrhage in the Medical Dictionary? fetomaternal hemorrhage explanation free. What is fetomaternal hemorrhage? Meaning of fetomaternal hemorrhage medical term. What does fetomaternal hemorrhage mean?
G.K. Sachdev, H.R. Dalton, P. Hoang, B. Crotty, D.P. Jewell; Human Colonic Intra-Epithelial Lymphocytes Suppress in vitro Immunoglobulin Synthesis by Autologous Peripheral Blood Lymphocytes. Clin Sci (Lond) 1 October 1991; 81 (s25): 26P-27P. doi: https://doi.org/10.1042/cs081026Pc. Download citation file:. ...
Objective: To determine the response to IV anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi. Methods: A total of 23 patients with chronic ITP were treated with either anti-D or splenectomy as second line treatment. The patients were assessed for time to achieve a response to second line treatment, duration ofresponse and adverse events. Results: There were 12 patients in the anti-D group and 11 in the splenectomy group. The mean platelet count at presentation was 9,000/cumm. The mean age was 8.9 years and 13.0 years and the male to female ratio was 1:1 and 1:1.2 in anti-D and splenectomy group respectively. 54.5% of the patient in the anti-D group responded compared to 81.8% in the splenectomy group. Median time to achieve a response was 7 days in the anti-D group and 1 day in the splenectomy group. Mean time to relapse was 87.8 days in the anti-D group and 55.4 days in the splenectomy
Junctional adhesion molecule-C (JAM-C) is an adhesion molecule involved in transendothelial migration of leukocytes. In this study, we examined JAM-C expression in the synovium and investigated the role of this molecule in two experimental mouse models of arthritis. JAM-C expression was investigated by reverse transcriptase-polymerase chain reaction and immunohistochemistry. The effects of a monoclonal anti-JAM-C antibody were assessed in antigen-induced arthritis (AIA) and K/BxN serum transfer-induced arthritis. JAM-C was expressed by synovial fibroblasts in the lining layer and associated with vessels in the sublining layer in human and mouse arthritic synovial tissue. In human tissue, JAM-C expression was increased in rheumatoid arthritis (RA) as compared to osteoarthritis synovial samples (12.7 ± 1.3 arbitrary units in RA versus 3.3 ± 1.1 in OA; p | 0.05). Treatment of mice with a monoclonal anti-JAM-C antibody decreased the severity of AIA. Neutrophil infiltration into inflamed joints was
Looking for hepatitis B immune globulin? Find out information about hepatitis B immune globulin. any of a large family of proteins protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant... Explanation of hepatitis B immune globulin
The B-chain of the acidic subunit of crotoxin proved refractory to Edman degradation. When subjected to sequence analysis using tandem mass spectrometry, pyroglutamate was found at the amino-terminal end, even though earlier attempts to de-block with pyroglutamate aminopeptidase were unsuccessful. The B-chain contained 35 amino acids and showed 91% amino acid identity with the corresponding segment from Mojave toxin, a homologous neurotoxin from Crotalus scutulatus scutulatus. The sequence of the last 24 residues of the B-chain is consistent with that previously published (Aird, S.D., Kaiser, I.I., Lewis, R.V. and Kruggel, W.G. (1985) Biochemistry 24, 7054-7058), except at position 20, where Edman degradation gave glycine and mass spectrometry gave glutamic acid ...
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Events following which immunoglobulin (Ig) G anti-D should be given to all RhD negative women with no anti-D alloantibodies: First trimester indications (IgG anti-D sufficient dose of 50 μg*) - termination of pregnancy, spontaneous abortion followed by instrumentation, ectopic pregnancy, chorionic villus sampling, partial molar pregnancy; Second and third trimester indications (IgG anti-D sufficient dose of 100 μg*) - amniocentesis, cordocentesis, other invasive prenatal diagnostic or therapeutic procedures, spontaneous or induced abortion, intrauterine fetal death, attempt at external cephalic version of a breech presentation, abdominal trauma, obstetric hemorrhage; Antenatal prophylaxis at 28th weeks of gestation (IgG anti-D sufficient dose of 250 μg*); Delivery of an RhD positive infant** (IgG anti-D sufficient dose of 100 μg*); Minimal dose*: before 20 weeks gestation - 50 μg (250 IU), after 20 weeks gestation*** - 100 μg (500 IU); Timing: as soon as possible, but no later than 72 ...
The discovery at the end of the 1960s that the Australia antigen (now called hepatitis B surface antigen [HBsAg]) is a component of hepatitis B virus (HBV) opened the door to preparation of hepatitis B immune globulin (HBIG) having titers of specific antibody (anti-HBs) many hundredfold times higher than those in standard immune serum globulin (ISG). As rapidly as anti-HBs-rich units of plasma could be identified and batches of HBIG prepared, studies of prophylaxis of type B hepatitis were carried out (1-6). Unfortunately, these investigations did not provide an easily interpretable answer to relative usefulness of HBIG and ISG. Hence, ...
TY - JOUR. T1 - HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya. AU - Odhiambo, Eliud O.. AU - Datta, Dibyadyuti. AU - Guyah, Bernard. AU - Ayodo, George. AU - Ondigo, Bartholomew N.. AU - Abong'O, Benard O.. AU - John, Chandy. AU - Frosch, Anne E.P.. PY - 2019/8/30. Y1 - 2019/8/30. N2 - Background: HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses. Methods: HIV infected and uninfected adults were recruited from Bondo subcounty hospital in Western Kenya at the time of HIV testing (antiretroviral and co-trimoxazole prophylaxis naïve). Total and Plasmodium falciparum apical membrane antigen-1 (AMA1) and glutamate rich protein-R0 (GLURP-R0) specific IgM, IgG and IgG subclass ...
Shop Vicilin-like seed storage protein ELISA Kit, Recombinant Protein and Vicilin-like seed storage protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
MalaCards based summary : Stevens-Johnson Syndrome/toxic Epidermal Necrolysis, also known as stevens-johnson syndrome toxic epidermal necrolysis spectrum, is related to systemic lupus erythematosus and hypersensitivity syndrome, carbamazepine-induced. An important gene associated with Stevens-Johnson Syndrome/toxic Epidermal Necrolysis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Etanercept and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system ...
Define respiratory syncytial virus immune globulin intravenous. respiratory syncytial virus immune globulin intravenous synonyms, respiratory syncytial virus immune globulin intravenous pronunciation, respiratory syncytial virus immune globulin intravenous translation, English dictionary definition of respiratory syncytial virus immune globulin intravenous. n. 1. Any of a class of proteins that are widespread in blood plasma, milk, muscle, and plant seeds and that are insoluble in pure water but soluble in...
The glycinin A1bB2 homohexamer was isolated and purified from a mutant soybean cultivar containing glycinin composed of only A1bB2 and A5A4B3. The protein in 10 g defatted seed powder was extracted with 120 ml buffer A [30 mM Tris-HCl pH 8.0, 10 mM β--mercaptoethanol (βME), 1 mM EDTA, 0.1 mM p-amidinophenylmethanesulfonyl fluoride hydrochloride (p-APMSF), 0.02%(w/v) NaN3, 0.2 mM pepstatin A, 0.5 µg ml−1 leupeptin] by stirring for 2 h at room temperature. The soluble and insoluble materials were separated by centrifugation at 24 000g for 30 min at 277 K. 0.98 g l−1 NaHSO3 was added to the supernatant and the pH of the extract was adjusted to pH 6.4 with HCl at 277 K. After centrifugation at 24 000g for 30 min at 277 K, the precipitate was dissolved in 60 ml buffer B [0.2 M HEPES pH 7.0, 0.4 M NaCl, 10 mM βME, 1 mM EDTA, 0.1 mM p-APMSF, 0.02%(w/v) NaN3]. Ammonium sulfate was added to the aliquot to 50% saturation and stirred for 15 min at room temperature before centrifugation at 24 000g ...
TY - JOUR. T1 - Lung surfactant protein D (SP-D) response and regulation during acute and chronic lung injury. AU - Gaunsbaek, Maria Quisgaard. AU - Rasmussen, Karina Juhl. AU - Beers, Michael F.. AU - Atochina-Vasserman, Elena N.. AU - Hansen, Soren. PY - 2013/6. Y1 - 2013/6. N2 - Background: Surfactant protein D (SP-D) is a collection that plays important roles in modulating host defense functions and maintaining phospholipid homeostasis in the lung. The aim of current study was to characterize comparatively the SP-D response in bronchoalveolar lavage (BAL) and serum in three murine models of lung injury, using a validated ELISA technology for estimation of SP-D levels. Methods: Mice were exposed to lipopolysaccharide, bleomycin, or Pneumocystis carinii (Pc) and sacrificed at different time points. Results: In lipopolysaccharide-challenged mice, the level of SP-D in BAL increased within 6 h, peaked at 51 h (4,518 ng/ml), and returned to base level at 99 h (612 ng/ml). Serum levels of SP-D ...
A previously healthy 3 year old boy presented in a paediatric clinic with regional lymphadenitis of the submandibular and suboccipital glands. He was afebrile and did not have any other symptoms. There was no hepatosplenomegaly. No neurological signs were present on physical examination. As the boy might have been scratched by one of his pet cats, in accordance with a small cut on his scalp, CSD was suspected. It was serologically confirmed (enzyme linked immunosorbent assay (ELISA) B henselae IgG, 850 U/l; IgM, 250U/l) and he was treated with clarithromycin.. Six weeks after the onset of CSD, he showed difficulty in walking, inability to run or climb stairs, and frequent falls. Slowly progressive pain and a gait disorder were noted over a course of a further 8 weeks. On admission to our department there were no general signs and only a small submandibular lymph node remained. Mental state and cranial nerve examination were normal. He showed a symmetric distal muscle weakness in all limbs. A ...
AbstractSeed storage protein profiles were studied to evaluate the genetic diversity of a germplasm collection of the Caulorrhizae section of genus Arachis. Total seed storage protein of 28 accessions of Arachis pintoi and one of A. repens, collected in the Paranã, São Francisco and Jequitinhonha ri
TY - JOUR. T1 - Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways. AU - Orlandella, Francesca Maria. AU - Mariniello, Raffaela Mariarosaria. AU - Iervolino, Paola Lucia Chiara. AU - Auletta, Luigi. AU - De Stefano, Anna Elisa. AU - Ugolini, Clara. AU - Greco, Adelaide. AU - Mirabelli, Peppino. AU - Pane, Katia. AU - Franzese, Monica. AU - Denaro, Maria. AU - Basolo, Fulvio. AU - Salvatore, Giuliana. PY - 2019/7. Y1 - 2019/7. N2 - Junctional adhesion molecule A (JAM-A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM-A as one of the genes mostly deregulated. The quantitative real-time polymerase chain reaction and immunohistochemistry analyses showed that downregulation ...
Introduction. Helicobacter pylori, a gram-negative microorganism first isolated by Warren & Marshall in 1984, colonizes the human stomach and may cause type B gastritis and peptic ulcers. Colonization of the stomach by H. pylori is associated with increased risk of gastric cancer,1 and a number of other non-gut-related disorders, such as coronary disease2 and autoimmune diseases including autoimmune thyroiditis3 and chronic idiopathic thrombocytopenic purpura (cITP).4. cITP is a poorly understood acquired hemorrhagic disease which involves the destruction of platelets in the reticuloendothelial system induced by anti-platelet antibodies.5 To date an effective and safe treatment for cITP has not been established. cITP treatment has been restricted to therapies with the potential of causing significant toxicity and risks including immunosuppressive agents, such as corticosteroids, intravenous immunoglobulin therapy (IVIg), anti-D immunoglobulin (anti-D), rituximab and salvage splenectomy. ...
TY - JOUR. T1 - The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection. T2 - Results from a Korean nationwide, multicenter study. AU - Chang, Hyun Ha. AU - Lee, Won Kee. AU - Moon, Chisook. AU - Choi, Wonseok. AU - Yoon, Hee Jung. AU - Kim, Jieun. AU - Ryu, Seong Yeol. AU - Kim, Hyun Ah. AU - Jo, Yu Mi. AU - Kwon, Ki Tae. AU - Kim, Hye In. AU - Sohn, Jang Wook. AU - Yoon, Young Kyung. AU - Jung, Sook In. AU - Park, Kyung Hwa. AU - Kwon, Hyun Hee. AU - Lee, Mi Suk. AU - Kim, Young Keun. AU - Kim, Yeon Sook. AU - Hur, Jian. AU - Kim, Shin Woo. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. ...
Symptoms of Selective IgA Deficiency including 12 medical symptoms and signs of Selective IgA Deficiency, alternative diagnoses, misdiagnosis, and correct diagnosis for Selective IgA Deficiency signs or Selective IgA Deficiency symptoms.
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1. A radial immunodiffusion technique was used to determine the concentrations of five rat serum proteins, slow α1- and α2-globulin, transferrin, albumin and γ2-globulin before and after the induction of immune complex nephritis.. 2. Four weeks after immunization with renal tubular antigen significant increases in transferrin, slow α2-globulin and γ2-globulin concentrations were observed but albumin showed a significant fall and slow α1-globulin did not change.. 3. After the development of proteinuria 7 weeks after immunization significant falls in the concentrations of albumin transferrin and γ2-globulin were noted along with significant increases in the macroglobulins, slow α1- and α2-globulin, the changes being similar to those seen in the nephrotic syndrome in man.. 4. At the end of the experiment the typical ultrastructural features of immune complex nephritis were observed. ...
We designed a study for evaluate the efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenic purpura (ITP) patients with moderate thrombocytopenia.. If this eradication treatment is revealed effective on ITP patients with more than 30X109/L of platelet, it would be valuable treatment especially for young ITP patients with mild to moderate thrombocytopenia. ...
Abstract. Treatment options for patients with chronic refractory immune thrombocytopenic purpura (ITP) are limited. Because combination immunosuppressant thera
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Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions (1). Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. The collectins play an important role in innate immunity by binding to specific carbohydrate structures found on the surfaces of pathogenic microorganisms, including bacteria, viruses, yeasts, and parasitic protozoa. The binding promotes effector mechanisms such as aggregation, hindrance of infection, activation of phagocytes, and initiation of phagocytosis. After binding to microbial surfaces, MBL activates the complement system through a complement activation pathway, the MBL pathway, by using two recently identified serine proteases, MASP-1 and MASP-2, to activate C4 and C2 (2).. SP-D is mainly produced by alveolar type II cells but is also present in sweat, salivary, tear, and mammary glands ...
Coconut milk (CM) containing coconut oil extracted from the endosperm (meat) of coconut fruit is not stable and undergoes a rapid separation into a creaming layer at the top and a serum phase at the bottom. In this study, coconut milk was separated into coconut cream (CC) and coconut skim milk (CSM). The ability of proteins in CM, CC and CSM to form and stabilise oil-in-water (O/W) emulsions containing coconut oil was investigated. The unstable nature of coconut oil droplets in CM was found to be due to types of proteins adsorbed on the surface of oil droplets, which were predominantly 11S globulins, known to be hydrophobic and salt soluble proteins. The oil droplets stabilised by 11S globulins in CM and CC were larger in size and highly flocculated, probably due to hydrophobic interaction, thus resulting in rapid creaming and phase separation, compared to those stabilised by proteins (e.g. water-soluble albumins) in CSM. Smaller droplet size with less droplet flocculation and slower phase ...
The novel genetic material in the new canola lines was inserted into the canola variety, Westar, using Agrobacterium tumefaciens-mediated transformation with the disarmed Ti-plasmid pMOG625. The T-DNA contained both phytase and nptII genes. The phytase gene is under the control of the cruciferin A seed storage protein transcript promoter which includes a cruciferin signal peptide sequence. Its terminator is also from the cruciferin A seed storage protein transcript. Both controlling sequences were obtained from Brassica napus. The nptII gene is under the control of the NOS promoter and terminator with an Agrobacterium tumefaciens-derived open reading frame inserted between the gene and its terminator. The open reading frame consists of coding for 50 amino acids from the Agrobacterium ornithine-cyclo-deaminase ...
Looking for online definition of Bence-Jones proteinuria in the Medical Dictionary? Bence-Jones proteinuria explanation free. What is Bence-Jones proteinuria? Meaning of Bence-Jones proteinuria medical term. What does Bence-Jones proteinuria mean?
RPB039Hu01, Recombinant Surfactant Associated Protein D (SPD), 表面活性物质关联蛋白D(SPD)重组蛋白, SFTPD; COLEC7; PSP-D; SFTP4; SP-D; Pulmonary Surfactant Protein D; Collectin-7; Lung surfactant protein D | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Newborn Calf CR colostrum replacer for calves from Agrilabs provides essential globulin proteins, lipids and carbohydrates to give newborn calves a healthy start. Contains...
Acute haemolysis associated with clinical episodes of high-level Plasmodium falciparum parasitaemia was studied in 20 children from an holoendemic area (coastal Tanzania). The change in blood haemoglobin (Hb) concentration ranged from -46 to +5 g/L during the 72-h observation period and was linearly related to maximum parasitaemia. Balance studies between loss of blood Hb, increase in plasma Hb and appearance of Hb in the urine indicated that extravascular clearance of red cells was the predominant mode of erythrocyte clearance. Most subjects, however, showed minor signs of intravascular haemolysis. The plasma Hb was ≪1% of blood Hb and haemoglobinuria was detected in 14/20 children but the excretion of Hb in urine was |0.5% of total Hb loss. Haemoglobinuria was, however, a marker of severe haemolysis, since the maximum blood Hb loss in children without haemoglobinuria was 10 g/L. Erythrocyte-bound opsonins known to induce erythrophagocytosis, i.e., complement C3c fragments and autologous IgG, were
New DNA Sequences ======================= AF200324 AF200324 579bp DNA PLN 03-FEB-2000 Saccharomyces cerevisiae Tim18p (TIM18) gene, complete cds; nuclear gene for mitochondrial product. TIM18; Tim18p. =========== Updated Sequence Features/Annotations ============= D37948 D37948 1777bp DNA PLN 01-FEB-2000 Saccharomyces cerevisiae DNA for F1F0-ATPase alpha subunit precursor, complete cds. ATP1; F1F0-ATPase alpha subunit precursor; F1F0-ATPase alpha subunit. D37949 D37949 1778bp DNA PLN 01-FEB-2000 Saccharomyces cerevisiae DNA for defective F1F0-ATPase alpha subunit precursor, complete cds. F1F0-ATPase alphadefective F1F0-ATPase alpha subunit precursor; defective F1F0-ATPase alpha subunit. YSC9SF D00347 870bp DNA PLN 01-FEB-2000 Saccharomyces cerevisiae 9kDa stabilizing factor. ATP synthase; ATP synthase inhibitor protein; mitochondria; 9kDa stabilizing factor mature protein. YSCCOF D13230 2005bp DNA PLN 01-FEB-2000 Saccharomyces cerevisiae COF1 gene for cofilin, complete cds. cofilin; COF1. ...
United States Patent US. Cl. 260-112 B 5 Claims ABSTRACT OF THE DISCLOSURE This disclosure is concerned with the isolation and recovery of immunoglobulins A and M along with gamma globulin from a fraction obtained during the isolation of albumin and gamma globulin from venous plasma, said immunoglobulins being useful for the prophylaxis and treatment of bacterial and viral infections and as replacement therapy in immune deficiency syndromes. BACKGROUND OF THE INVENTION This invention relates to a method of isolating and recovering an immunoglobulin A encirched fraction and an immunoglobulin M enriched fraction, both fractions consisting essentially of gamma globulin and the respective immunoglobulin, from a byproduct fraction obtained from a process of isolating alubumin and gamma globulin from venous plasma, utilizing polyethylene glycol to isolate both the immunoglobulin A and immunoglobulin M fractions. Immunoglobulin A was first isolated from human serum by J. F. Heremans [Clin. Chim. Acta ...