Title: Synthetic Peptides: The Future of Patient Management in Systemic Rheumatic Diseases?. VOLUME: 14 ISSUE: 26. Author(s):Kai Kessenbrock, Reinout Raijmakers, Marvin J. Fritzler and Michael Mahler. Affiliation:Dr. Fooke Laboratorien GmbH,Mainstr.85, 41469 Neuss, Germany.. Keywords:Peptide, autoantibody, SLE, dsDNA, Systemic rheumatic disease. Abstract: Since the first description of self-reactive antibodies in systemic autoimmune rheumatic diseases, many autoantigens have been identified as useful diagnostic biomarkers in clinical immunology. Among the autoantigens, double-stranded desoxoribonucleic acid (dsDNA), the Smith antigen (Sm), topoisomerase-I (topo-I), proliferating cell nuclear antigen (PCNA), and others were described as hallmark targets of systemic autoimmune diseases. The detection of the corresponding autoantibodies can be performed with a variety of immunoassays based on native antigens, recombinant proteins or synthetic peptides. As discussed in this review, synthetic ...
Most of the inflammatory rheumatic diseases are systemic conditions with clinical and pathological manifestations outside of the joints. Many of the extra-articular manifestations of inflammatory rheumatic disease respond to the same treatments that target the joint disease itself, but some require specialised interventions. Ocular involvement is a common manifestation of inflammatory rheumatic disease and ranges from chronic troublesome symptoms, such as dry eye complicating Sjögren syndrome, to organ- and sight-threatening vasculitis. Isolated ocular abnormality has been reported to account for up to 4% of referrals to rheumatology clinics.1 Diagnosing and characterising serious ocular abnormalities are complicated by the need for specialised equipment and training - notably slit lamp and retinal examination - to fully assess eye disease. Consequently, it is incumbent on physicians involved in the care of patients with rheumatic disease to be aware of the potential ocular complications of ...
1 Centers for Disease Control and Prevention. Immunocompromised Travelers - Chapter 8 - 2014 Yellow Book , Travelers Health , CDC. Centers for Disease Control and Prevention; 2014. 2 van Assen S, Agmon-Levin N, Elkayam O, Cervera R, Doran MF, Dougados M, et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011;70:414-22. 3 Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:e44-e100. 4 Papadopoulou D, Sipsas NV. Comparison of national clinical practice guidelines and recommendations on vaccination of adult patients with autoimmune rheumatic diseases. Rheumatol Int. 2014;34:151-63. 5 Goeb V, Ardizzone M, Arnaud L, Avouac J, Baillet A, Belot A, et al. Recommendations for using TNFalpha antagonists and French Clinical Practice Guidelines endorsed by the French National Authority for Health. Joint, ...
Arthritis, which literally means inflammation of a joint (where two or more bones meet), actually refers to more than 100 different diseases. Rheumatic diseases include any diseases that cause pain, stiffness, and swelling in joints or other supportive body structures, such as muscles, tendons, ligaments, and bones. In fact, the group of arthritis diseases falls under the category of rheumatic diseases.. Arthritis and other rheumatic diseases are often mistakenly associated with old age, because osteoarthritis (the most common form of arthritis) occurs more often among older persons. However, arthritis and other rheumatic diseases affect people of all ages. ...
Arthritis, which literally means inflammation of a joint (where two or more bones meet), actually refers to more than 100 different diseases. Rheumatic diseases include any diseases that cause pain, stiffness, and swelling in joints or other supportive body structures, such as muscles, tendons, ligaments, and bones. In fact, the group of arthritis diseases falls under the category of rheumatic diseases.. Arthritis and other rheumatic diseases are often mistakenly associated with old age, because osteoarthritis (the most common form of arthritis) occurs more often among older persons. However, arthritis and other rheumatic diseases affect people of all ages. ...
We thank Castañeda et al1 for their interest in our paper2 and are pleased to have the opportunity to respond to their comments in order to clarify what part of the management of comorbidities we believe to be within the remit of rheumatologists, that is, what is likely to be done by the rheumatologist and what rheumatologists are able to do in the daily practice.. The European League Against Rheumatism (EULAR) task force anticipated that the screening of a wide scope of comorbidities would make the final process too complex or too extensive to be implemented. The EULAR task force acknowledged that fibromyalgia impacts on the assessment of the disease activity and response to treatment of chronic inflammatory rheumatic diseases (CIRDs). American College of Rheumatology 1990 classification criteria for fibromyalgia3 and recent recommendations4 considered fibromyalgia as a diagnosis of exclusion that requires a specific visit in order to rule out other disorders that could be the cause of ...
Patients with by systemic rheumatic diseases (SRDs) are at significantly greater risk of cardiovascular (CV) risk factors, CV events, and mortality than the general population. Although CV involvement in such patients is highly heterogeneous and may affect various structures of the heart, it can now be diagnosed earlier and promptly treated.The examinations used include transthoracic or transesophageal echocardiography, magnetic resonance imaging (MRI), and computed tomography (CT) to investigate valve abnormalities, pericardial disease and ventricular wall motion defects. Coronary arteries can be investigated invasively using quantitative coronarography or intravascular ultrasound (IVUS) to assess coronary diameter, or non-invasively using transthoracic or transesophageal ultrasonography (US), MRI, positron emission tomography (PET) after endothelium-dependent vasodilatory provocation, or CT to assess coronary flow reserve. Finally, peripheral circulation can be measured invasively by means of the
Nat Clin Pract Rheumatol. 2008 Apr;4(4):184-91 Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease. Authors:
Technology Insight: hematopoietic stem cell (HSCs) transplantation for systemic rheumatic disease. Transplantation of HSCs for the treatment of autoimmune di...
This study deals with the important phenomenon of oxidative stress induced by the chronic inflammatory state in rheumatic patients of various categories and stages of disease. It investigates the local (knee joint) and systemic inflammatory response index and oxidative injury by measuring a major PGF2α metabolite, 15-keto-dihydro-PGF2α, and F2-isoprostane in the synovial fluid and blood, respectively. To our knowledge this study is the first to report a high concentration of 8-iso-PGF2α and moderately high levels of 15-keto-dihydro-PGF2α in various types of rheumatic patients in both synovial fluid and peripheral blood collected from the same patients. These results indicate that both non-enzymatic free radical and enzymatic cyclo-oxygenase catalysed oxidation of arachidonic acid occur in various types of rheumatic diseases, such as RA, OA, ReA, and PsA. In addition to the findings of this study, we have seen high levels of F2-isoprostanes and PGF2α metabolite in both synovial fluid and ...
Aim: The overall aim of this thesis with a salutogenic approach was to describe health promoting factors in people with chronic musculoskeletal pain and in people with rheumatic diseases, and to evaluate the effects of an intervention study with a self-care promoting PBL-program for people with rheumatic diseases having chronic musculoskeletal pain, sleep disturbances and/or fatigue.. Methods: This thesis is comprised of four samples: a randomly selected sample from a Swedish general population (study I) and three different samples containing people with rheumatic diseases registered at a hospital for rheumatic diseases in the southwest of Sweden (studies II, III and IV). Study I had a longitudinal cohort design with an eight-year follow-up in a general population. There were 1109 participants without chronic pain and 700 participants with chronic musculoskeletal pain. Study II had a longitudinal cohort design with participants with rheumatic diseases (n=185) 12 months after rehabilitation at a ...
Purpose: Gaining new knowledge in glucocorticoid research. The dissertation consists of two parts: 1. Clinical study on effects and side-effects of a low-dose / medium-dose therapy with methylprednisolone (MP) in patients with inflammatory rheumatic diseases. 2. Flowcytometric investigation of human PBMC in order to detect membrane-bound glucocorticoid-receptors (mGCR). Methods: 1. In a clinical study two groups of patients - 20 patients each - were compared. All patients had inflammatory rheumatic diseases and recieved MP-therapy for at least one year. The first group recieved a low-dose GC-therapy, the second group a medium-dose GC-therapy. 2. Human PBMC were examined. We used conventional and high-sensitive liposome staining technique for the detection of specific membrane-bound antigens. Results: 1. In most cases rather low dosages of MP were able to control the disease activitiy of inflammatory rheumatic diseaeses. However, we observed disease exacerbation in some cases. Most side-effects ...
Results. In patients with suspected systemic rheumatic diseases, 72% satisfied American College of Rheumatology classification criteria: 40 (36%) had rheumatoid arthritis (RA), 16 (15%) systemic lupus erythematosus, 8 (7%) scleroderma, 8 (7%) osteoarthritis, 4 (4%) fibromyalgia, 2 (2%) seronegative spondyloarthropathy, 1 Sjögrens syndrome, and 1 sarcoidosis. Compared to controls, RA patient sera were more likely to contain anti-CCP (55% vs 2%; p , 0.001) or RF IgM antibodies (57% vs 10%; p , 0.001); however, the difference was greater for anti-CCP. Anti-CCP positivity conferred higher disease activity scores (DAS28 5.6 vs 4.45; p = 0.021) while RF positivity did not (DAS28 5.36 vs 4.64; p = 0.15). Anticardiolipin antibodies (25% of rheumatic disease patients vs 10% of controls; p = 0.0022) and ANA (63% vs 21%; p , 0.0001) were more common in rheumatic disease patients. ...
Most rheumatological diagnoses are made through effective history taking and physical examination rather than investigation.Systemic symptoms, such as weight loss, anorexia, and fever, point to systemic diseases such as rheumatoid arthritis, other polyarthritides, systemic lupus erythematosus, polymyalgia, and vasculitides. Swelling of joints is a symptom commonly reported by patients with no objective evidence of this on examination. Inflammatory arthropathies should not be diagnosed unless the physician is able to identify objective swelling, if necessary by arranging a prompt review during an active episode. Diagnostic criteria for the systemic rheumatic diseases are useful in directing the history taking to verify a suspected diagnosis....
Patients across the spectrum of rheumatic diseases, not just those with rheumatoid arthritis, have a significantly increased prevalence of cardiovascular risk factors compared with the general population, the results of a Dutch study indicate.
Web-based rheumatic manifestations of systemic diseases tool for residents in rheumatology rotation and self-study for rheumatology health professionals.
The causes and mechanisms of late-onset neutropenia (LON) following rituximab treatment in patients with rheumatic diseases are not known. In this study, we aimed to investigate the role of established Fcγ receptor gene (FCGR) polymorphisms and B-cell-activating factor (BAFF) gene promoter polymorphisms for the development of LON and for the efficacy of rituximab in patients with rheumatic diseases. A single-center case-control retrospective study was nested in a cohort of 214 consecutive patients with rheumatic diseases treated with rituximab. Eleven patients presented with LON. Fifty non-LON control subjects were matched by diagnosis, age, sex, and treatments. Single-nucleotide polymorphisms of FCGR (FCGR2A 131H/R, FCGR2B 232I/T, FCGR3A 158V/F) and BAFF promoter polymorphism −871C/T were analyzed with polymerase chain reaction-based techniques, and serum immunoglobulin M (IgM) and BAFF levels were analyzed by enzyme-linked immunosorbent assay. Flare-free survival was related to LON occurrence and
The idea that rheumatic diseases might be triggered by infectious microorganisms first occurred to Dr. Conditions, , Metronidazole in combination with amoxicillin has also been utilized. Arthritis and Other Rheumatic Diseases. Franco when he was still. We are trying to improve the way search works. An unusual or allergic reaction to metronidazole, parabens, nitroimidazoles, or other medicines. For a Classification of Periodontal Diseases and. Franco and Antibiotic Treatment. Guidelines for selection of contraception in women with rheumatic diseases. ...
Purpose: Farming has been previously associated with the autoimmune rheumatic diseases (ARD), including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The exposure(s) underlying this association are not well-understood, and few studies have directly addressed the role of pesticides, including personal and residential insecticide use. Method: Using data from the Womens Health Initiative Observational Study (n=76,861, aged 50-79 years), we examined self-reported lifetime personal or commercial residential insecticide use and having lived or worked on a farm in relation to risk of incident ARD, confirmed by use of disease modifying anti-rheumatic drugs at year 3 of follow-up (n=213; 178 with RA only, 27 with SLE only, and 8 with both RA and SLE), and excluding unconfirmed cases. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by multivariate models adjusting for age and covariates, including race, region, education, occupation, history of smoking, asthma, ...
Background:Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population. Methods:A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence. Stakeholders completed three tasks to develop, individually rank, and reach consensus on research priorities: Task 1 - mapping challenges and services using visual timelines; Task 2 - identifying research topics; Task 3 - individually ranking research topics in priority order. Results of the ranking exercise were fed back to the group for comment. Results:The main themes emerging from Task 1 were the need for provision of information, multi-disciplinary care, and social and peer ...
INTRODUCTION: The introduction of biological disease-modifying antirheumatic drugs (bDMARDs) has improved the treatment of inflammatory rheumatic diseases dramatically. However, bDMARD treatment failure occurs in 30%-40% of patients due to lack of effect or adverse events, and the tools to predict treatment outcomes in individual patients are currently limited. The objective of the present study is to identify diagnostic, prognostic and predictive biomarkers, which can be used to (1) diagnose inflammatory rheumatic diseases early in the disease course with high sensitivity and specificity, (2) improve prognostication or (3) predict and monitor treatment effectiveness and tolerability for the individual patient ...
Any antigen that elicits a humoral immune response may give rise to circulating immune complexes if the antigen remains present in abundant quantities once antibody is generated. Immune complexes are efficiently cleared in most circumstances by the reticuloendothelial system and are rarely pathogenic. Their pathogenic potential is realized when circulating immune complexes are deposited in the subendothelium, where they set in motion the complement cascade and activate myelomonocytic cells. The propensity for immune complexes to deposit is a function of the relative amounts of antigen and antibody and of the intrinsic features of the complex (ie, composition, size, and solubility). The solubility of immune complexes is not a fixed property, because it is profoundly influenced by the relative concentrations of antigen and antibody, which generally change as an immune response evolves. For physicochemical reasons, soluble immune complexes formed at slight antigen excess are not effectively cleared ...
Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.Ann Rheum Dis. 2017 Jun;76(6):1150-1158. Avouac J, Konstantinova I, Guignabert C, Pezet S, Sadoine J, Guilbert T, Cauvet A, Tu L, Luccarini JM, Junien JL, Broqua P, Allanore Y. Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 ...
Treatment of inflammatory rheumatic conditions with glucocorticosteroids is a mainstay in therapy. In rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematodes and polymyalgia rheumatica glucocorticosteroids show a prompt effect in regards of musculoskeletal symptoms.. Ankylosing spondylitis (AS) is an inflammatory rheumatic disease mainly affecting the spine. However peripheral joints, entheses and the eyes can also be affected. The rheumatic symptoms of AS patients typically show good and quick response to treatment with nonsteroidal antirheumatic drugs (NSAIDs). In contrast to rheumatoid arthritis there is no proof that disease modifying antirheumatic drugs (DMARDs) work. Surprisingly there is the common opinion, mainly based on personal experiences, that glucocorticosteroids in spondylarthropathies do not work. However there are no reliable clinical studies answering this question. In the literature of the last 20 years there are only single reports about the treatment of ...
Detailed information on the most common types of arthritis and other rheumatic diseases, including ankylosing spondylitis, bursitis, carpal tunnel syndrome, fibromyalgia, gout, infectious arthritis, juvenile rheumatoid arthritis, lyme disease, low back pa
Detailed information on arthritis and other rheumatic diseases, including types, diagnosis, treatment, and living with the condition
TY - CHAP. T1 - Overview of rheumatology and rheumatic conditions. AU - Mikuls, Ted R.. AU - Thiele, Geoffrey M.. AU - Moore, Gerald F.. AU - Craig, Steven. AU - Cannella, Amy C.. AU - Bilek, Laura D.. PY - 2013/1/1. Y1 - 2013/1/1. N2 - RHEUMATOLOGY AND RHEUMATIC CONDITIONS - OVERVIEW Rheumatology is an internal medicine and pediatric subspecialty focused on the diagnosis and management of diseases affecting primarily the joints and surrounding soft tissues. Rheumatic conditions are composed of arthritis and its allied connective tissue diseases. The term arthritis is derived from the Greek arthro (meaning joint) and -itis (meaning inflam mation). There are currently more than 100 discrete forms of arthritis recognized, the most common being osteoarthritis (OA). Arthritis is often categorized by its distribution (monoarticular vs. polyarticular); its association with detectable autoantibody (seropositive vs. seronegative); or the degree of underlying inflammation involved (inflammatory vs. ...
Although different medical treatments have greatly improved the situation for patients with rheumatic diseases, much is still unknown regarding factors that predict a healthier outcome. The School of Health Sciences in Jönköping has, in collaboration with Spenshult Hospital for Rheumatic Diseases (the only one of its kind in Sweden), several projects that highlight the patients perspective of rheumatic diseases. "One important finding in ongoing studies is a healthier outcome in subjects who feel rested after sleep, but emotional support, sleep patterns, smoking and alcohol habits also appear to be important components. Knowledge of health factors associated to the development of a good health-related quality of life could be of use in clinical practice and public health work," says Professor Bengt Fridlund, School of Health Sciences ...
Recently the concerns about the Health-Related Quality of Life (HRQOL) have been increasing especially in chronic diseases. Rheumatic disease is a chronic disease, which can result in a functional disability and impaired HRQOL. Because of this chronic pain, patients with rheumatic disease have lower scores on HRQOL than general population. A several studies have indicated Ultracet as an add-on treatment to nonsteroidal antiinflammatory drugs(NSAIDs) for osteoarthritis(OA) pain, fibromyalgia pain and chronic low back pain significantly improved HRQOL, compared with placebo. We will use the KEQ-5D (a Korean version of the EQ-5D which is a health related quality of life questionnaire) to assess HRQOL. The KEQ-5D has been shown to be effectively sensitive in several rheumatic conditions. The study hypothesis is that the quality of life will be improved after Tramadol 37.5mg/Acetaminophen 325mg tablets administration in outpatients who need Tramadol 37.5mg/Acetaminophen 325mg tablets administration ...
This page contains articles and posts with the latest news on Arthritis, Osteoporosis & Rheumatic Conditions. It also provides links to sub-pages with in-depth information on Arthritis, Osteoporosis & Rheumatic Conditions, including What are these conditions and What causes them; symptoms & diagnosis; prevention; treatment; and caregiving for Arthritis, Osteoporosis & Rheumatic Conditions.
RhEumAtic Disease activitY - Collect quantitative disease activity measures on rheumatic disease patients. An iPad application intended for Rheumatology practices that collects patient reported outcome (PRO) and (optionally) clinician-derived data to collect, calculate, and sto
Yale Continuing Medical Education, Yale Rheumatology State of the Art Symposium: Pre-autoimmunity and the Prevention of Rheumatic Diseases, 4/23/2021 7:00:00 AM - 4/23/2021 5:00:00 PM, |p> Recent progress in our understanding of the development of autoimmunity suggests the opportunity of intervening in the prodromal phase of rheumatic diseases to prevent the future onset of clinically-apparent disease, such as arthritis or other disease manifestations. |/p>|p>This one-day international symposium will bring thought leaders together to review the conceptual basis and available clinical data for implementing preventive strategies in rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune and rheumatic conditions. Topics will include the definition of at-risk individuals, interventions under study, and prospects for new approaches in basic scientific and clinical investigation, and for the design of therapeutic clinical trials.|/p>
Note: to read the full text of the editorial summarized below, click here. And to read the research paper it introduces, "Experimental stress in inflammatory rheumatic diseases: A review of psychophysiological stress responses," click here ...
Somewhat contrary to most medical practices today, in particular with the slow economy and the new Healthcare Bill, Arthritis and Rheumatic Disease Specialties has continued to expand its facility in Aventura, FL.. The practice founded by Dr. Norman Gaylis over 23 years ago has achieved local, national, and international recognition for its excellence in diagnosing and treating patients with arthritis & rheumatic diseases. Some of the patients who come to the facility are looking for additional recommendations after seeing other physicians for their musculoskeletal problems and others are seeking a facility where they can receive treatment which is not available to them at their current physicians office.. The location behind the Aventura Hospital, 21097 NE 27th Court, Suite 200, has recently added an additional 2500 square feet to their existing space making the total space 9500 sq. ft. The facility is entirely dedicated to treating patients with arthritis and rheumatic disorders. Arthritis & ...
PURPOSE: Patients with rheumatic diseases have an increasing risk of opportunistic infections, particularly tuberculosis (TB). The aim of this study is to elucidate the diagnostic and treatment problems of pulmonary TB developing in patients with rheumatic diseases. METHODS: All patients with rheumatic diseases and concurrently newly active pulmonary TB, seen at Hanyang university hospital between January 2009 and December 2011, were selected as cases. For comparison purposes, patients without rheumatic diseases, who had newly diagnosed active pulmonary TB in respiratory clinic during the same 3-year study period, were also selected as control subjects. We performed a retrospective analysis of the medical record of 30 patients suffering from active pulmonary TB with rheumatic diseases and 193 without rheumatic diseases. RESULTS: Of 30 patients who enrolled as cases, patients with rheumatoid arthritis were 20 (66.7%). Asymptomatic patients were more frequent in rheumatic diseases than control ...
An international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of clinical and experimental rheumatology in the clinic and laboratory including pathology, pathophysiology of rheumatological diseases, pathology, pathophysiology of rheumatological diseases, investigation, treatment and management of rheumatological diseases, clinical trials and novel pharmacological approaches for the treatment of rheumatological disorders.
Livia Casciola-Rosen Ph.D. is a Professor of Medicine. After graduating from the University of Cape Town with a doctoral degree in medical biochemistry, she pursued postdoctoral training in Cell Biology at the Johns Hopkins University School of Medicine. She initially joined the faculty in the Department of Dermatology at Johns Hopkins, and subsequently became a faculty member in Rheumatology.Dr. Casciola-Rosens research has been focused on the shared mechanisms underlying the autoimmune rheumatic diseases, particularly myositis, Sjogrens syndrome, and scleroderma. Dr. Casciola-Rosen has collaborated closely with Dr. Rosen, using disease-specific autoantibodies as probes to define the events that initiate and drive the autoimmune response in the rheumatic diseases. Dr. Casciola-Rosen also runs the Bioassay Core within the rheumatic diseases research core center, which provides a variety of immune assays to investigators studying the mechanisms of the autoimmune rheumatic diseases.Dr. Casciola-Rosens
The objective of this study was to study the association of physical, verbal, and sexual abuse in patients with rheumatic disorders as compared with h
Read Rhuematic Rarities, An Issue of Rheumatic Disease Clinics, E-book by Jonathan Kay, MD with Rakuten Kobo. Guest edited by Jonathan Kay, this issue of Rheumatic Disease Clinics will cover the latest research and evidence surrou...
用 Kobo 閱讀 Jonathan Kay, MD 的 Rhuematic Rarities, An Issue of Rheumatic Disease Clinics, E-book。Guest edited by Jonathan Kay, this issue of Rheumatic Disease Clinics will cover the latest research and evidence surrou...
Find out which foods and supplements have been touted for treating rheumatic diseases — and which ones may be dangerous. Get answers at Everyday Health.
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Rheumatic Diseases Laminated Chart on NCBTMB Resource Center | This rheumatic disease chart shows the anatomy of this disease in colorful detail. Other…
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Objective: To investigate the rote of anti-nucleosome antibodies (AnuA) in systemic lupus erythematosus (SLE).. Methods: IgG anti-nucleosome antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in the sera of 233 SLE and 220 other rheumatic diseases′ patients as well as 31 health controls. The patients were also evaluated for clinical and biological parameters.. Results: (1) Out of 233 SLE patients, 144 (61.8%) were seropositive for AnuA, which was significantly higher than that of patients with other rheumatic diseases [2.7% (6/220), P < 0.001]; the sensitivities and specificities of AnuA in SLE were 61.8% and 97.6%, respectively. (2) The positive rated of AnuA in SLE lacking of anti-DNP, anti-cmDNA, anti-Sm and anti-dsDNA antibodies were 57.1%, 55.9%, 62.4% and 51.2%, respectively. (3) The frequency of the fever, skin rash, and arthralgia were significantly higher in 144 positive AnuA SLE than those in AnuA negative SLE (P < 0.05). The frequency of leukopenia, elevations of ...
Rheumatic diseases are more than just aches and pains. These diseases can affect most parts of your body including your organs and muscles, as well as your joints.
The authors discuss the importance of neurological complications of rheumatic disease, which differ from those of Sydenhams chorea: encephalitis; acute cerebral circulatory insufficiency of cardiovascular basis; thrombosis and cerebral haemorrhage; cerebral emboli; and vasculitis. The case of a 13 year old boy who presented with an acute cerebral episode during an active phase of rheumatic fever is described. The E.E.G. showed a right hemisphere disturbance with a slight involvement of the controlateral hemisphere. The cardiac evidence was indicative of a rheumatic carditis. The clinical progress and EEG were rapidly favourable. The possible pathogenetic hypotheses of this case are taken into consideration, and the authors suggest that one must suspect a rheumatic etiology when an acute cerebral syndrome is established in a child or a young adult with current or previous rheumatic fever.
The origin of the word rheumatic goes back to ancient Greece. In ancient Greece, people thought that bad fluid circulated the body and when such fluid accumulated in the hands or feet, it resulted in arthritis in which the joints swell and cause pain. Therefore, rheumatic originates from the Greek term, rheuma which means circulation of bad fluid. Other than rheumatoid arthritis, rheumatic diseases cover autoimmune diseases such as ankylosing spondylitis, inflammatory myositis, systemic sclerosis and systemic lupus erythematosus, and degenerative and metabolic diseases such as degenerative arthritis, gout and osteoporosis. Rheumatic diseases cause chronic pain and limit activity. Therefore, they cause pain in each individual patient as well as enormous economic and social loss for all of society. The Department of Rheumatology assists patients to quickly treat their illnesses and recover their function through precise diagnosis and treatment for various rheumatic diseases.. ...
3) OTHER CORONARY CONDITIONS: Aspirin can be used to treat patients who have had certain revascularization procedures such as angioplasty, and coronary bypass operations -- if they have a vascular condition for which aspirin is already indicated.. 4) RHEUMATOLOGIC DISEASES -- Aspirin is indicated for relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondylarthropathies, and arthritis and pleurisy associated with systemic lupus erythematosus.. Q. What does this mean for doctors and medical practice?. A. Doctors and health care professionals will be provided with full prescribing information about the use of aspirin in both men and women who have had a heart attack, stroke, certain other cardiovascular conditions and rheumatologic diseases. For stroke and cardiovascular conditions, lower doses are recommended than those previously prescribed by physicians in practice. Information on the use of aspirin for rheumatologic diseases has also been ...
3) OTHER CORONARY CONDITIONS: Aspirin can be used to treat patients who have had certain revascularization procedures such as angioplasty, and coronary bypass operations -- if they have a vascular condition for which aspirin is already indicated.. 4) RHEUMATOLOGIC DISEASES -- Aspirin is indicated for relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondylarthropathies, and arthritis and pleurisy associated with systemic lupus erythematosus.. Q. What does this mean for doctors and medical practice?. A. Doctors and health care professionals will be provided with full prescribing information about the use of aspirin in both men and women who have had a heart attack, stroke, certain other cardiovascular conditions and rheumatologic diseases. For stroke and cardiovascular conditions, lower doses are recommended than those previously prescribed by physicians in practice. Information on the use of aspirin for rheumatologic diseases has also been ...