Title: Synthetic Peptides: The Future of Patient Management in Systemic Rheumatic Diseases?. VOLUME: 14 ISSUE: 26. Author(s):Kai Kessenbrock, Reinout Raijmakers, Marvin J. Fritzler and Michael Mahler. Affiliation:Dr. Fooke Laboratorien GmbH,Mainstr.85, 41469 Neuss, Germany.. Keywords:Peptide, autoantibody, SLE, dsDNA, Systemic rheumatic disease. Abstract: Since the first description of self-reactive antibodies in systemic autoimmune rheumatic diseases, many autoantigens have been identified as useful diagnostic biomarkers in clinical immunology. Among the autoantigens, double-stranded desoxoribonucleic acid (dsDNA), the Smith antigen (Sm), topoisomerase-I (topo-I), proliferating cell nuclear antigen (PCNA), and others were described as hallmark targets of systemic autoimmune diseases. The detection of the corresponding autoantibodies can be performed with a variety of immunoassays based on native antigens, recombinant proteins or synthetic peptides. As discussed in this review, synthetic ...
The transcapillary escape rate of albumin was measured in 27 consecutive patients with inflammatory rheumatic diseases before and after 1 and 7 days of prednisone treatment in doses of 45 mg/day. The transcapillary escape rate decreased from 7.33%/h (range 5.11-9.55) before prednisone treatment to 3.11%/h (0.04-6.18) (p less than 0.05) after 1 day of treatment and 5.80%/h (4.36-7.24) after 7 days of treatment. It is concluded that prednisone inhibits vascular permeability in patients with inflammatory rheumatic diseases. ...
Most of the inflammatory rheumatic diseases are systemic conditions with clinical and pathological manifestations outside of the joints. Many of the extra-articular manifestations of inflammatory rheumatic disease respond to the same treatments that target the joint disease itself, but some require specialised interventions. Ocular involvement is a common manifestation of inflammatory rheumatic disease and ranges from chronic troublesome symptoms, such as dry eye complicating Sjögren syndrome, to organ- and sight-threatening vasculitis. Isolated ocular abnormality has been reported to account for up to 4% of referrals to rheumatology clinics.1 Diagnosing and characterising serious ocular abnormalities are complicated by the need for specialised equipment and training - notably slit lamp and retinal examination - to fully assess eye disease. Consequently, it is incumbent on physicians involved in the care of patients with rheumatic disease to be aware of the potential ocular complications of ...
1 Centers for Disease Control and Prevention. Immunocompromised Travelers - Chapter 8 - 2014 Yellow Book , Travelers Health , CDC. Centers for Disease Control and Prevention; 2014. 2 van Assen S, Agmon-Levin N, Elkayam O, Cervera R, Doran MF, Dougados M, et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011;70:414-22. 3 Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:e44-e100. 4 Papadopoulou D, Sipsas NV. Comparison of national clinical practice guidelines and recommendations on vaccination of adult patients with autoimmune rheumatic diseases. Rheumatol Int. 2014;34:151-63. 5 Goeb V, Ardizzone M, Arnaud L, Avouac J, Baillet A, Belot A, et al. Recommendations for using TNFalpha antagonists and French Clinical Practice Guidelines endorsed by the French National Authority for Health. Joint, ...
Arthritis, which literally means inflammation of a joint (where two or more bones meet), actually refers to more than 100 different diseases. Rheumatic diseases include any diseases that cause pain, stiffness, and swelling in joints or other supportive body structures, such as muscles, tendons, ligaments, and bones. In fact, the group of arthritis diseases falls under the category of rheumatic diseases.. Arthritis and other rheumatic diseases are often mistakenly associated with old age, because osteoarthritis (the most common form of arthritis) occurs more often among older persons. However, arthritis and other rheumatic diseases affect people of all ages. ...
Arthritis, which literally means inflammation of a joint (where two or more bones meet), actually refers to more than 100 different diseases. Rheumatic diseases include any diseases that cause pain, stiffness, and swelling in joints or other supportive body structures, such as muscles, tendons, ligaments, and bones. In fact, the group of arthritis diseases falls under the category of rheumatic diseases.. Arthritis and other rheumatic diseases are often mistakenly associated with old age, because osteoarthritis (the most common form of arthritis) occurs more often among older persons. However, arthritis and other rheumatic diseases affect people of all ages. ...
We thank Castañeda et al1 for their interest in our paper2 and are pleased to have the opportunity to respond to their comments in order to clarify what part of the management of comorbidities we believe to be within the remit of rheumatologists, that is, what is likely to be done by the rheumatologist and what rheumatologists are able to do in the daily practice.. The European League Against Rheumatism (EULAR) task force anticipated that the screening of a wide scope of comorbidities would make the final process too complex or too extensive to be implemented. The EULAR task force acknowledged that fibromyalgia impacts on the assessment of the disease activity and response to treatment of chronic inflammatory rheumatic diseases (CIRDs). American College of Rheumatology 1990 classification criteria for fibromyalgia3 and recent recommendations4 considered fibromyalgia as a diagnosis of exclusion that requires a specific visit in order to rule out other disorders that could be the cause of ...
Patients with by systemic rheumatic diseases (SRDs) are at significantly greater risk of cardiovascular (CV) risk factors, CV events, and mortality than the general population. Although CV involvement in such patients is highly heterogeneous and may affect various structures of the heart, it can now be diagnosed earlier and promptly treated.The examinations used include transthoracic or transesophageal echocardiography, magnetic resonance imaging (MRI), and computed tomography (CT) to investigate valve abnormalities, pericardial disease and ventricular wall motion defects. Coronary arteries can be investigated invasively using quantitative coronarography or intravascular ultrasound (IVUS) to assess coronary diameter, or non-invasively using transthoracic or transesophageal ultrasonography (US), MRI, positron emission tomography (PET) after endothelium-dependent vasodilatory provocation, or CT to assess coronary flow reserve. Finally, peripheral circulation can be measured invasively by means of the
Nat Clin Pract Rheumatol. 2008 Apr;4(4):184-91 Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease. Authors:
Technology Insight: hematopoietic stem cell (HSCs) transplantation for systemic rheumatic disease. Transplantation of HSCs for the treatment of autoimmune di...
It is recommended to evaluate the presence of latent tuberculosis infection (LTBI) before initiating antitumor necrosis factor alpha (anti-TNF) therapy for rheumatologic diseases. We aimed to present the follow-up results of 192 patients with rheumatologic diseases before anti-TNF therapy for LTBI. We enrolled 192 patients who were given anti-TNF therapy for their rheumatologic diseases between April 2005 and January 2008. The demographic characteristics of the patients were recorded. Chest X-ray was obtained and tuberculin skin test (TST) was performed in all patients before anti-TNF therapy. LTBI was assessed by detailed history of close contact with infectious cases within the last year, abnormal chest radiography, and positive TST (>= 5 mm) before initiating anti-TNF therapy. Patients with anti-TNF therapy were followed with 2-month intervals for active tuberculosis by pulmonary and extrapulmonary symptoms, physical examination, and chest X-ray. Of 192 patients, 104 (54.2%) patients were ...
This study deals with the important phenomenon of oxidative stress induced by the chronic inflammatory state in rheumatic patients of various categories and stages of disease. It investigates the local (knee joint) and systemic inflammatory response index and oxidative injury by measuring a major PGF2α metabolite, 15-keto-dihydro-PGF2α, and F2-isoprostane in the synovial fluid and blood, respectively. To our knowledge this study is the first to report a high concentration of 8-iso-PGF2α and moderately high levels of 15-keto-dihydro-PGF2α in various types of rheumatic patients in both synovial fluid and peripheral blood collected from the same patients. These results indicate that both non-enzymatic free radical and enzymatic cyclo-oxygenase catalysed oxidation of arachidonic acid occur in various types of rheumatic diseases, such as RA, OA, ReA, and PsA. In addition to the findings of this study, we have seen high levels of F2-isoprostanes and PGF2α metabolite in both synovial fluid and ...
Aim: The overall aim of this thesis with a salutogenic approach was to describe health promoting factors in people with chronic musculoskeletal pain and in people with rheumatic diseases, and to evaluate the effects of an intervention study with a self-care promoting PBL-program for people with rheumatic diseases having chronic musculoskeletal pain, sleep disturbances and/or fatigue.. Methods: This thesis is comprised of four samples: a randomly selected sample from a Swedish general population (study I) and three different samples containing people with rheumatic diseases registered at a hospital for rheumatic diseases in the southwest of Sweden (studies II, III and IV). Study I had a longitudinal cohort design with an eight-year follow-up in a general population. There were 1109 participants without chronic pain and 700 participants with chronic musculoskeletal pain. Study II had a longitudinal cohort design with participants with rheumatic diseases (n=185) 12 months after rehabilitation at a ...
The main study published on this topic is based on the database of the Global Rheumatology Alliance (GRA) including 3000 patients with AIIRD.11 This study analysed the risk factors for hospitalisations among AIIRD patients with COVID-19. It reported an increased risk for hospitalisation (46%) and death (9%) among patients with SLE and vasculitis. For the whole population of patients with AIIRD, the main risk factors for hospitalisation were similar to those known in the general population, such as age and cardiovascular diseases.11 Patients of Afro-American, Latin and Asian origins were at increased risk for hospitalisation.12 In the subsequent analysis by the GRA group, factors associated with COVID-19-related death among 3729 patients with rheumatic diseases were reported.13 In addition to the known general factors (older age, male sex and specific comorbidities), disease-specific factors, including high disease activity at COVID-19 diagnosis and treatment with glucocorticoids (≥10 mg/day ...
Specialists from different medical specialties need to gain familiarity with reproductive health issues in women with chronic rheumatic diseases of childbearing age. Health care providers must have easy access to summary recommendations for management of pregnancy, antenatal care, and care in the postpartum period. This book is intended as a quick-access guide of the most up-to-date understanding of the interplay between pregnancy and rheumatic diseases and principles of management before, during, and after pregnancy assisting in decision-making regarding treatment of women with autoimmune diseases. The book intends to provide concise, clinically relevant topics and cases with management recommendations for all providers who may encounter women of child-bearing age including rheumatologists, gynaecologists, paediatricians, primary care providers, nurses, midwives, and other health professionals dealing with pre-conceptional and pregnant women with rheumatic diseases. Aided by the discussion of 70
Purpose: Gaining new knowledge in glucocorticoid research. The dissertation consists of two parts: 1. Clinical study on effects and side-effects of a low-dose / medium-dose therapy with methylprednisolone (MP) in patients with inflammatory rheumatic diseases. 2. Flowcytometric investigation of human PBMC in order to detect membrane-bound glucocorticoid-receptors (mGCR). Methods: 1. In a clinical study two groups of patients - 20 patients each - were compared. All patients had inflammatory rheumatic diseases and recieved MP-therapy for at least one year. The first group recieved a low-dose GC-therapy, the second group a medium-dose GC-therapy. 2. Human PBMC were examined. We used conventional and high-sensitive liposome staining technique for the detection of specific membrane-bound antigens. Results: 1. In most cases rather low dosages of MP were able to control the disease activitiy of inflammatory rheumatic diseaeses. However, we observed disease exacerbation in some cases. Most side-effects ...
BACKGROUND: The recent outbreak of COVID-19 has raised concerns in the rheumatology community about the management of immunosuppressed patients diagnosed with inflammatory rheumatic diseases. It is not clear whether the use of biological agents may suppose a risk or protection against SARS-CoV-2 infection; however, it has been suggested that severe respiratory forms of COVID-19 occur as a result of exacerbated inflammation status and cytokine production. This prompted the use of interleukin 6 (IL-6) (tocilizumab and sarilumab) and IL-1 inhibitors (anakinra) in severe COVID-19 disease and more recently JAK1/2 inhibitor (baricitinib). Therefore, patients with rheumatic diseases provide a great opportunity to learn about the use of biological agents as protective drugs against SARS-CoV-2. OBJECTIVES: To estimate COVID-19 infection rate in patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) for inflammatory rheumatic diseases (RMD), determine the influence of biological ...
Results. In patients with suspected systemic rheumatic diseases, 72% satisfied American College of Rheumatology classification criteria: 40 (36%) had rheumatoid arthritis (RA), 16 (15%) systemic lupus erythematosus, 8 (7%) scleroderma, 8 (7%) osteoarthritis, 4 (4%) fibromyalgia, 2 (2%) seronegative spondyloarthropathy, 1 Sjögrens syndrome, and 1 sarcoidosis. Compared to controls, RA patient sera were more likely to contain anti-CCP (55% vs 2%; p , 0.001) or RF IgM antibodies (57% vs 10%; p , 0.001); however, the difference was greater for anti-CCP. Anti-CCP positivity conferred higher disease activity scores (DAS28 5.6 vs 4.45; p = 0.021) while RF positivity did not (DAS28 5.36 vs 4.64; p = 0.15). Anticardiolipin antibodies (25% of rheumatic disease patients vs 10% of controls; p = 0.0022) and ANA (63% vs 21%; p , 0.0001) were more common in rheumatic disease patients. ...
Most rheumatological diagnoses are made through effective history taking and physical examination rather than investigation.Systemic symptoms, such as weight loss, anorexia, and fever, point to systemic diseases such as rheumatoid arthritis, other polyarthritides, systemic lupus erythematosus, polymyalgia, and vasculitides. Swelling of joints is a symptom commonly reported by patients with no objective evidence of this on examination. Inflammatory arthropathies should not be diagnosed unless the physician is able to identify objective swelling, if necessary by arranging a prompt review during an active episode. Diagnostic criteria for the systemic rheumatic diseases are useful in directing the history taking to verify a suspected diagnosis....
Patients across the spectrum of rheumatic diseases, not just those with rheumatoid arthritis, have a significantly increased prevalence of cardiovascular risk factors compared with the general population, the results of a Dutch study indicate.
Low-dose aspirin may be considered for the primary prevention of cardiovascular disease (CVD) in patients with autoimmune systemic rheumatic diseases who are at particularly high risk because of their individual cardiovascular risk profile, according to authors of a new review article in the journal Rheumatology who acknowledge the controversial nature of the issue, because while significant cardiovascular benefit from aspirin for secondary prevention is well established, it has not been for primary prevention.. Secondary prevention with daily, low-dose aspirin is part of aggressive, comprehensive risk modification in patients who have experienced an MI or stroke or are considered at high risk for CVD. But when it comes to primary prevention of the onset of disease, the authors, led by Serena Fasano, MD, PhD, of the rheumatology unit at the University of Campania, Naples, Italy, acknowledged the contradictory positions of international guidelines and uncertainty over balancing benefit versus ...
Web-based rheumatic manifestations of systemic diseases tool for residents in rheumatology rotation and self-study for rheumatology health professionals.
The causes and mechanisms of late-onset neutropenia (LON) following rituximab treatment in patients with rheumatic diseases are not known. In this study, we aimed to investigate the role of established Fcγ receptor gene (FCGR) polymorphisms and B-cell-activating factor (BAFF) gene promoter polymorphisms for the development of LON and for the efficacy of rituximab in patients with rheumatic diseases. A single-center case-control retrospective study was nested in a cohort of 214 consecutive patients with rheumatic diseases treated with rituximab. Eleven patients presented with LON. Fifty non-LON control subjects were matched by diagnosis, age, sex, and treatments. Single-nucleotide polymorphisms of FCGR (FCGR2A 131H/R, FCGR2B 232I/T, FCGR3A 158V/F) and BAFF promoter polymorphism −871C/T were analyzed with polymerase chain reaction-based techniques, and serum immunoglobulin M (IgM) and BAFF levels were analyzed by enzyme-linked immunosorbent assay. Flare-free survival was related to LON occurrence and
The idea that rheumatic diseases might be triggered by infectious microorganisms first occurred to Dr. Conditions, , Metronidazole in combination with amoxicillin has also been utilized. Arthritis and Other Rheumatic Diseases. Franco when he was still. We are trying to improve the way search works. An unusual or allergic reaction to metronidazole, parabens, nitroimidazoles, or other medicines. For a Classification of Periodontal Diseases and. Franco and Antibiotic Treatment. Guidelines for selection of contraception in women with rheumatic diseases. ...
Purpose: Farming has been previously associated with the autoimmune rheumatic diseases (ARD), including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The exposure(s) underlying this association are not well-understood, and few studies have directly addressed the role of pesticides, including personal and residential insecticide use. Method: Using data from the Womens Health Initiative Observational Study (n=76,861, aged 50-79 years), we examined self-reported lifetime personal or commercial residential insecticide use and having lived or worked on a farm in relation to risk of incident ARD, confirmed by use of disease modifying anti-rheumatic drugs at year 3 of follow-up (n=213; 178 with RA only, 27 with SLE only, and 8 with both RA and SLE), and excluding unconfirmed cases. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by multivariate models adjusting for age and covariates, including race, region, education, occupation, history of smoking, asthma, ...
Background:Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population. Methods:A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence. Stakeholders completed three tasks to develop, individually rank, and reach consensus on research priorities: Task 1 - mapping challenges and services using visual timelines; Task 2 - identifying research topics; Task 3 - individually ranking research topics in priority order. Results of the ranking exercise were fed back to the group for comment. Results:The main themes emerging from Task 1 were the need for provision of information, multi-disciplinary care, and social and peer ...
Background/Aims: The high incidence of cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs) is the main driver towards increased mortality in this patient group. Cardiovascular magnetic resonance (CMR) can non-invasively and robustly detect CVD in ARD patients at an early stage of development. The review summarises the diagnostic information provided by CMR in ARD patients. Summary : CMR uses a strong magnetic field combined with radio-frequency pulses (pulse sequences) to generate images. Firstly, balanced steady-state free precession(bSSFP) can be used for evaluating cardiac anatomy, mass, wall motion, atrial/ventricular function. Secondly, T2-weighted imaging (T2-W) can be used for oedema detection, which appears as a high signal intensity area on STIR (short tau inversion recovery) images. T2 mapping is a newer T2-W technique that can provide more optimal identification of myocardial oedema. Lastly, late gadolinium enhanced (LGE) T1-W images, taken 15 min. after
Being able to use ultrasound in rheumatology at the point of care is currently revolutionising the management of patients suffering from inflammatory rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and other peripheral spondyloarthropathies. This means that an early diagnosis can be established (at the point of care), and subsequent treatment can be initiated which has an evidence base for improving disease outcomes, in these largely chronic and debilitating diseases.. Inflammatory rheumatic diseases present with either synovitis/synovial hypertrophy, synovial effusions, tenosynovitis or erosive disease or commonly a combination of all these findings. Ultrasound has shown its usefulness and value in early inflammatory arthritis by being able to accurately detect these changes with either superior or equivalent accuracy compared to other imaging modalities such as x ray and MRI. The obvious advantages of ultrasound are that it is performed in real time and is well ...
INTRODUCTION: The introduction of biological disease-modifying antirheumatic drugs (bDMARDs) has improved the treatment of inflammatory rheumatic diseases dramatically. However, bDMARD treatment failure occurs in 30%-40% of patients due to lack of effect or adverse events, and the tools to predict treatment outcomes in individual patients are currently limited. The objective of the present study is to identify diagnostic, prognostic and predictive biomarkers, which can be used to (1) diagnose inflammatory rheumatic diseases early in the disease course with high sensitivity and specificity, (2) improve prognostication or (3) predict and monitor treatment effectiveness and tolerability for the individual patient ...
Any antigen that elicits a humoral immune response may give rise to circulating immune complexes if the antigen remains present in abundant quantities once antibody is generated. Immune complexes are efficiently cleared in most circumstances by the reticuloendothelial system and are rarely pathogenic. Their pathogenic potential is realized when circulating immune complexes are deposited in the subendothelium, where they set in motion the complement cascade and activate myelomonocytic cells. The propensity for immune complexes to deposit is a function of the relative amounts of antigen and antibody and of the intrinsic features of the complex (ie, composition, size, and solubility). The solubility of immune complexes is not a fixed property, because it is profoundly influenced by the relative concentrations of antigen and antibody, which generally change as an immune response evolves. For physicochemical reasons, soluble immune complexes formed at slight antigen excess are not effectively cleared ...
Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.Ann Rheum Dis. 2017 Jun;76(6):1150-1158. Avouac J, Konstantinova I, Guignabert C, Pezet S, Sadoine J, Guilbert T, Cauvet A, Tu L, Luccarini JM, Junien JL, Broqua P, Allanore Y. Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 ...
Treatment of inflammatory rheumatic conditions with glucocorticosteroids is a mainstay in therapy. In rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematodes and polymyalgia rheumatica glucocorticosteroids show a prompt effect in regards of musculoskeletal symptoms.. Ankylosing spondylitis (AS) is an inflammatory rheumatic disease mainly affecting the spine. However peripheral joints, entheses and the eyes can also be affected. The rheumatic symptoms of AS patients typically show good and quick response to treatment with nonsteroidal antirheumatic drugs (NSAIDs). In contrast to rheumatoid arthritis there is no proof that disease modifying antirheumatic drugs (DMARDs) work. Surprisingly there is the common opinion, mainly based on personal experiences, that glucocorticosteroids in spondylarthropathies do not work. However there are no reliable clinical studies answering this question. In the literature of the last 20 years there are only single reports about the treatment of ...
Detailed information on the most common types of arthritis and other rheumatic diseases, including ankylosing spondylitis, bursitis, carpal tunnel syndrome, fibromyalgia, gout, infectious arthritis, juvenile rheumatoid arthritis, lyme disease, low back pa
Detailed information on arthritis and other rheumatic diseases, including types, diagnosis, treatment, and living with the condition
Detailed information on arthritis and other rheumatic diseases, including types, diagnosis, treatment, and living with the condition
TY - CHAP. T1 - Overview of rheumatology and rheumatic conditions. AU - Mikuls, Ted R.. AU - Thiele, Geoffrey M.. AU - Moore, Gerald F.. AU - Craig, Steven. AU - Cannella, Amy C.. AU - Bilek, Laura D.. PY - 2013/1/1. Y1 - 2013/1/1. N2 - RHEUMATOLOGY AND RHEUMATIC CONDITIONS - OVERVIEW Rheumatology is an internal medicine and pediatric subspecialty focused on the diagnosis and management of diseases affecting primarily the joints and surrounding soft tissues. Rheumatic conditions are composed of arthritis and its allied connective tissue diseases. The term arthritis is derived from the Greek arthro (meaning joint) and -itis (meaning inflam mation). There are currently more than 100 discrete forms of arthritis recognized, the most common being osteoarthritis (OA). Arthritis is often categorized by its distribution (monoarticular vs. polyarticular); its association with detectable autoantibody (seropositive vs. seronegative); or the degree of underlying inflammation involved (inflammatory vs. ...
BACKGROUND: As yet, whole-body cryotherapy is especially used for the therapy of chronic inflammatory arthritis. An analgetic effect has been described in several studies. However, only few data exist concerning the long-term effects of this therapy.. PATIENTS AND METHODS: A total of 60 patients with rheumatoid arthritis (n • 48), and ankylosing spondylitis (n • 12) was analyzed. Patients underwent treatment with whole-body cryotherapy twice a day. The average age was 55.7 +1- 10.33. The study group consisted of 48 female and twelve male patients. The average number of therapeutic treatments with cryotherapy was 15.8 +1- 8.37, the average follow-up 63.4 +1- 63.48 days.. RESULTS: 13 patients (21.7%) discontinued treatment because of adverse effects. For patients with rheumatoid arthritis, DAS28 (Disease Activity Score) and VAS (visual analog scale) were determined. A significant reduction of both parameters was found (DAS 3.9 +1- 1.22 vs. 3.4 +1- 1.08: p , 0.01: VAS 51.4 +1- 16.62 vs. 37.9 ...
The influence of the presence of an inflammatory rheumatic disease and its treatment on the severity of and immune response to (viral) infections is not clear. The emergence and pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) provides the opportunity to assess these influences on COVID-19 incidence, its clinical severity, and the antibody response, compared to a control population. The primary objective will be to compare the disease severity of COVID-19 between patients with a systemic autoimmune disease and a control group. Disease severity is defined as the (unplanned) hospital admission rate of participants that are both IgM- or IgG-SARS-CoV-2 antibody positive and symptomatic. Symptomatic is defined as symptoms or signs of nasopharyngitis, cough, dyspnea, fever, or any other symptom or sign that may be associated with a viral infection, as assessed by the patient. Unplanned refers to the fact that elective hospital admissions (e.g., for planned surgery) are ...
TY - JOUR. T1 - Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others. AU - Puig, Lluís. PY - 2017/1/1. Y1 - 2017/1/1. N2 - © 2018 S. Karger AG, Basel. Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease. Paradoxical reactions have subsequently been reported with other biological drugs or classes (e.g., tocilizumab), even though in some cases insufficient efficacy or phenotype switch may be difficult to differentiate ...
Kaltsonoudis et al.9 conducted a prospective study in 77 patients with inflammatory rheumatic disease (36 patients with rheumatoid arthritis, 24 patients with psoriatic arthritis and 17 patients with ankylosing spondylitis) who began with anti-TNFα (infliximab, adalimumab, etanercept). All underwent a complete neurological examination, nuclear magnetic resonance of the brain and the entire spine, and a neurophysiology study before and more than 18 months after starting the biological therapy. In the initial scrutiny, they detected lesions compatible with demyelinating disease in magnetic resonance in 2 patients and, thus, decided against the biological treatment. At the end of the study, 4% of the patients (3/75) showed evidence of neurological involvement: peripheral demyelinating neuropathy (2 patients) and optic neuritis. In each case, the biological therapy was interrupted and the neurological disease was treated. The neurological symptoms remitted in all the patients.9 The authors stress ...
Positive phase 3 results for certolizumab pegol in axial spondyloarthritis , a broad family of inflammatory rheumatic diseases which includes ankylosing spondyl
An increased risk of cardiovascular disease is well established in inflammatory rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis [3], over and above the risk explained by conventional cardiovascular risk factors. This increase appears to be related to chronic inflammation, with elevated levels of C-reactive protein associated with increased risk of cardiovascular disease, including PAD [4]. Atherosclerosis itself can be explained as an inflammatory process, with proinflammatory cytokines key in the development of endothelial dysfunction and the progression of atheromatous lesions.. Homocysteine has been implicated in the development of atherosclerotic disease in the general population, and in patients with systemic lupus erythematosus and rheumatoid arthritis. Levels of homocysteine have also been found to be elevated in PMR [5].. Although Warrington and colleagues found no correlation between PAD and PMR-related disease characteristics or the erythrocyte ...
Medical definition of rheumatic disease: any of several diseases (as rheumatic fever or fibrositis) characterized by inflammation and pain in muscles or joints : rheumatism.
Biologic therapies (eg, monoclonal antibodies) targeting inflammation have changed the prognosis of inflammatory rheumatic diseases such as rheumatoid arthritis. However, this improvement in care has come with important costs, leading to our health systems having difficulties to cope with. Biosimilars are biologic therapies presenting high similarities to the originator biologic with only subtle structural differences (eg, glycosylation). They usually come with a 20% lower price than the originator biologic. To be marketed, a biosimilar must provide scientific evidence that its structure and pharmacokinetics are highly similar to the originator (pharmacological equivalence) as well as a similar clinical efficacy (clinical equivalence). Our study concludes that even if initially well accepted, the switch to a biosimilar can induce a nocebo effect that physicians should be aware of. Further research is needed to better understand patient acceptance and to better address the switch to a ...
Bio-Rad Helix EIA ANA Screen Bulk Kit,The ANA and ENA assays can be used to screen out patients negative for antinuclear antibodies, which are associated with various systemic rheumatic diseases such as Systemic lupus erythematosus (Lupus), Sjgrens syndrome, mixed connective tissue disease, progressive systemic sclerosis, scleroderma,,medicine,medical supply,medical supplies,medical product
Sting Nettle is a flower plant in the genus Urtica, belonging tothe family Urticaceae, native to Europe, Africa, Asia, and North America.The herb has been used in traditional medicine as diuretic and laxative agent and to treat diarrhea and urinary disorders, to relieve pain, treat arthritis, asthma, bronchitis, sinusitis, etc. The potent herbal medicine may be used for relive pain, especially in inflammatory rheumatic disease(207). According to the University of California, extract of Urtica dioica (the stinging nettle) prepared using accelerated solvent extraction (ASE) involving water may be used for treatment of diseases associated to inflammatory disorders as the portion displayed significant anti-inflammatory activity through inhibited the pro inflammatory pathways(208 ...
Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease that mainly affects patients above the age of 50 years and occurs twice as often in women than in men. Patients typically pre...
Bio-Rad Helix EIA ENA Screen Bulk Kit,The ANA and ENA assays can be used to screen out patients negative for antinuclear antibodies, which are associated with various systemic rheumatic diseases such as Systemic lupus erythematosus (Lupus), Sjgrens syndrome, mixed connective tissue disease, progressive systemic sclerosis, scleroderma,,medicine,medical supply,medical supplies,medical product
The antinuclear antibody (ANA) test is widely used as a serological marker of autoimmune disease. Antinuclear antibodies are immunoglobulins or antibodies that bind to one or more antigens expressed within the nucleus of human cells. Used selectively, the ANA test can be a useful laboratory tool to help confirm or exclude the diagnosis of systemic rheumatic disease. However, the relatively high prevalence of ANAs in other inflammatory conditions, as well as healthy individuals, can make a positive result difficult to interpret.
TY - JOUR. T1 - Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region. AU - Lee, Kyung Jong. AU - Dong, Xingwen. AU - Wang, Jingsong. AU - Takeda, Yoshihiko. AU - Dynan, William S.. PY - 2002/9/15. Y1 - 2002/9/15. N2 - The nonhomologous end-joining pathway is the principal mechanism for repair of ionizing radiation-induced, double-strand breaks in mammalian cells. Three polypeptides in this pathway, including the two subunits of Ku protein and the catalytic subunit of the DNA-dependent protein kinase, are known targets of autoantibodies in systemic rheumatic diseases. Here we show that two additional polypeptides in the pathway, DNA ligase IV and XRCC4, are also targets of autoantibodies. These Abs were present in 20% of patients with systemic lupus erythematosus and overlap syndrome. Previous work has shown that XRCC4 is subject to radiation-induced post-translational modification, including ...
Difference between rosacea and lupus rash - I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. Im on plaquenil. Why are all my other antibodies neg for lupus? Maybe SLE maybe not. Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis.
Health Survey Reports 2017. This week data from representative surveys on health behaviours have been made available by the the Department of Health (ROI) and the Department of Health (NI). Northern Ireland. First results from Health Survey Northern Ireland 2016/17 are now available. This annual survey collects information on the health behaviours of the population in Northern Ireland age 16 and older. Prevalence of smoking has fallen to 20%, with 62% of smokers reporting that they wanted to quit and 75% reporting that they had tried to stop smoking. The proportion of the population eating 5 or more portions of fruit or vegetables in a day rose from 37% to 43% over the last two survey years. 36% of the adult population are overweight, and 27% are obese, with no increase on last year but a general upward trend in obesity over the decade.. Republic of Ireland. The publication of the Northern Ireland data coincides with the publication of data from the Healthy Ireland Survey 2017 in the Republic of ...
Experiments have been described in which we attempted to reproduce in animals the lesions characteristic of rheumatic fever in the human. A large number of animals representing 7 species was employed. Among other materials, streptococci isolated in pure culture from the blood of rheumatic patients (proved to be so by biopsy or by autopsy) as well as whole blood, plasma, serum, pericardial, pleural and hydrocele fluid, filtrates from tonsils, subcutaneous nodules, lymph nodes, and nasopharyngeal washings obtained from such patients were used in a variety of combinations and with a number of procedures calculated to predispose the animal to the disease.. A discussion is given of the criteria whose fulfillment is essential for the establishment of the experimental production of rheumatic disease in animals.. Judged by these criteria, we have failed to reproduce the disease. This conclusion, we believe, holds true for all the work thus far reported in the literature.. ...
We are glad to announce that the Saudi Society of Rheumatology (SSR) will be registering all its members - including fellows - for the EULAR 2020 E-Congress that will be held virtually during June 3-6, 2020. This step came after touching the high interest of our community of attending virtual activities during the current situation of COVID-19 pandemic, as well as to get the recent international scientific updates and guidelines in Rheumatological diseases management. We urge all colleagues to register through the below link by May 15th in order to consolidate the participants list and communicate it to the EULAR secretariat. Finally, we would like to thank Pfizer Saudi Arabia for their support to partner in this valuable program to better raise the capabilities and knowledge of Saudi Rheumatology community.. ...
Pulmonary hypertension can occur by itself or may be related to different rheumatologic conditions, most importantly scleroderma, lupus, and mixed connective tissue disease (MCTD). Our rheumatologists routinely partner with the team of physicians and allied health professionals of the Pulmonary Hypertension Program, including cardiologists and pulmonologists, to help detect rheumatologic disorders in patients presenting with PAH, and to help treat and monitor patients who have PAH related to a rheumatologic disorder. Clinical Services ...
From the University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network; Division of Rheumatology, Department of Medicine, and Department of Immunology, University of Toronto; Arthritis Centre of Excellence, Division of Health Care and Outcomes Research, Toronto Western Hospital Research Institute, University Health Network; Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. A.J. Steiman, MD, MSc, FRCP, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, and Division of Rheumatology, Department of Medicine, University of Toronto; D.D. Gladman, MD, FRCP, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, and Division ...
Philip Hench made important advances in the understanding and hormonal treatment of arthritis and other rheumatic diseases. For his accomplishments, he received part of the 1950 Nobel prize for physiology or medicine, which he shared with his co-worker Edward Kendall and Tadeus Reichstein, who had isolatedcortisone in 1936.. Hench was born in Pittsburgh, Pennsylvania, where his father was a teacher. He graduated from Lafayette College in 1912 and received his medical degree in1920 from the University of Pittsburgh Medical School. He was affiliated with the Mayo Clinic in Rochester, Minnesota in 1921, specializing in such rheumatic diseases as rheumatoid arthritis, which is characterized by swelling of the joints.. In the 1930s, Henchs Mayo Clinic colleague Edward Kendall was studying the pituitary gland hormone ACTH (adrenocorticotropic hormone) and the adrenal gland hormones scortisol and cortisone. ACTH signals the adrenal gland to produce cortisol, and both cortisone and cortisol block the ...
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Events - ACR/ARHP Scientific Meeting 2015 - American College of Rheumatology/Association of Rheumatology Health Professionals - Moscone Center - San Francisco - California - United States - United States - Event Overview:\r\nSave the date for the 2015 ACR/ARHP Annual Meeting in San Francisco, CA on November 6 - 11. You wont want to miss rheumatologys premier scientific meeting for anyone involved in research or delivery of rheumatologic care or services.Each year, this event features the latest innovations, science, business and clinical best practices. Get first-hand access to the latest discoveries and research transforming rheumatic disease care. Or, focus on clinical applications that will improve health for your patients today. Take time to join your colleagues to focus on the prevention, diagnosis and treatment of rheumatic disease. Experience personalized learning that allows you to expand your knowledge to new areas of interest and focus on your specialty.\r\nExhibitor Information:\r\nThe 2015
Arthritis Research & Therapy is an international, peer-reviewed online journal, publishing original research, reviews, commentaries and reports. The major focus of the journal is on cellular and molecular mechanisms of arthritis, musculoskeletal conditions and systemic autoimmune rheumatic diseases and translation of this knowledge into advances in clinical care. Original basic, translational laboratory and clinical research is considered for publication along with results of therapeutic trials.. All articles are available online, and in addition the website offers many other services: ...
Systemic sclerosis (SSc; scleroderma) and systemic lupus erythematosus (SLE;lupus) are autoimmune rheumatic diseases. While the etiologies of SSc and SLE are unknown, both genetic and environmental factors are thought to be important. Cytotoxic T lymphocyte antigen-4 (CTLA-4; CDI52), a negative co-stimulatory molecule on activated T cells, plays a pivotal role in immune homeostasis. The cytokine interleukin10 (IL-IO) has diverse immune modulating activities, such as promoting B cell survival and class switching and inhibiting fibroblast proliferation. Particular genetic variants of CTLA-4 and IL-I 0 are associated with levels of these proteins and susceptibility to autoimmune diseases. Environmental exposure to the organic sol vent trichloroethylene (TCE) is a risk factor for SSc and SLE. Infection with the Epstein-Barr virus (EBV) is also implicated in SLE etiology. Activation of microchimeric (allogeneic) cells is postulated to play a role in the etiology of SLE and SSc, in part because they ...
Welcome to Team Jaffari. Please walk with on October 5th or if you cannot walk with us, please consider donating to our cause. We walk for those suffering from this debilitating disease.. Donating through this website is simple, fast and totally secure. It is also the most efficient way to support my fundraising efforts. All contributions are for the Scleroderma Foundation to use to help find a cure for those whose lives have been affected by scleroderma.. Scleroderma - misunderstood, misdiagnosed, underfunded - is a chronic connective tissue disease, classified as one of the autoimmune rheumatic diseases.The disease affects 300,000 people, 80% of which are women. The disease is complex and painful, and it has the potential to affect every organ in a persons body. The disease can be localized or systemic. If it is localized it affects mainly the skin by hardening the skin. If it is systemic it can affect organs by hardening the organs. The cause is unknown, and there is no cure. The SFDV ...
Please help by joining my team on behalf of this important cause! If you dont think you are able to participate but would still like to support the organization and my efforts, please click on the Donate Now.. Donating through this website is simple, fast and totally secure. It is also the most efficient way to support my fundraising efforts. All contributions are for the Scleroderma Foundation to use to help find a cure for those whose lives have been affected by scleroderma. Scleroderma - misunderstood, misdiagnosed, underfunded - is a chronic connective tissue disease, classified as one of the autoimmune rheumatic diseases. The disease affects 300,000 people, 80% of which are women. The disease is complex and painful, and it has the potential to affect every organ in a persons body. The disease can be localized or systemic. If it is localized it affects mainly the skin by hardening the skin. If it is systemic it can affect organs by hardening the organs. The cause is unknown, and there is ...
This course is an overview and has drawn from several sources. As a result there may some repletion or duplication of information. Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word
We present the case of a 48-year-old premenopausal woman with right lumbosciatalgia secondary to osteoporosic vertebral collapses. Two of her three offsprings, a 31-year-old man and a 16-year-old woman, had chronic dorsolumbalgia, the study of which suggested the diagnosis of minor beta-thalassemia. As opposed to thalassemic osteoarthropathy, frequently observed in the forms of major and minor beta-thalassemia, rheumatic manifestations have almost never been described in the minor forms. We highlight the possibility of symptomatic osteoporosis as the first manifestation and we review the locomotive disorders associated to this hemoglobinopathy ...
OBJECTIVE: This study aimed to characterise rheumatic manifestations and autoantibodies in 432 patients diagnosed with infective endocarditis (IE) in Shanghai. DESIGN, SETTING AND PARTICIPANTS: A retrospective study was conducted in Ruijin Hospital from 1997 to 2017. The clinical and laboratory characteristics of a total of 432 patients were analysed. In addition, the differences between patients with positive and negative antineutrophil cytoplasmic antibodies (ANCA) and antiphospholipid (aPL) antibodies as well as the survival rates of these patients were compared. RESULTS: A total of 432 patients, including 278 male patients and 154 female patients, were included. The mean age of the patients was 46±16 years. A total of 346 patients (80%) had cardiac surgery, and 55 patients (13%) died in the hospital. Among the IE patients, 104 were tested for either ANCA or aPL and were analysed in different groups. Twenty-one (24%) positive ANCA patients were proteinase 3-ANCA positive. Compared with the ...
How can one get online advice for homeopathy treatment? No, many conventional medicines attempt to suppress symptoms without allowing the body to heal itself, sometimes resulting in harmful side effects. Also, since homeopathic medicines have no side effects, this reduces the percentage of iatrogenic (doctor-induced) diseases. The treatment of autoimmune rheumatic diseases has gradually improved over the last half century, which has been expanded with the contribution of biological therapies or immunobiopharmaceuticals. Its called Solasodine rhamnosyl glycosides (BEC), which is a fancy name for extracts from plants of the Solanaceae family, such as eggplant, tomato, potato, Bell peppers, and tobacco. The results upon treatment with a cream formulation of BEC (eggplant extract) twice a day are astounding:. Whats even better than an inexpensive, safe, and natural cure for skin cancer is, of course, preventing it in the first place. Unlike tanning beds, home UVB devices are designed solely for ...