TY - JOUR. T1 - Guideline recommendations for oral care after stroke: A systematic review protocol. AU - Gurgel-Juarez, Nalia Cecilia. AU - Perrier, Marie-France. AU - Hoffmann, Tammy. AU - Jolliffe, Laura. AU - Lannin, Natasha. AU - Lee, Rachel. AU - Brosseau, Lucie. AU - Flowers, Heather. PY - 2019/10. Y1 - 2019/10. N2 - Introduction: There have been recent advancements in the development of guidelines for rehabilitation after stroke. Nevertheless, recommendations for specific practice areas such as oral care often lack adequate information for clinical processes and actions to attain evidence-based care.Methods: We have developed a protocol to update a recent systematic review of clinical practice guidelines for stroke1 and to appraise existing recommendations for oral care provision. The search strategy includes a search of MEDLINE and EMBASE with MeSH and user-defined terms, 20 organizational and best-practice websites, and reference lists of accepted guidelines. Guideline appraisal will ...
TY - JOUR. T1 - The economic cost of robotic rehabilitation for adult stroke patients. T2 - A systematic review protocol. AU - Lo, Kenneth. AU - Stephenson, Matthew. AU - Lockwood, Craig. PY - 2018/8/1. Y1 - 2018/8/1. N2 - Review question/objective: The objective of this review is to identify the best available evidence on the economic cost of robotic rehabilitation for adult stroke patients to improve their motor movement abilities. More specifically, the objective is to identify the evidence on the economic cost of robotic training compared to conventional physiotherapy for adult stroke patients, from the perspective of hospitals.. AB - Review question/objective: The objective of this review is to identify the best available evidence on the economic cost of robotic rehabilitation for adult stroke patients to improve their motor movement abilities. More specifically, the objective is to identify the evidence on the economic cost of robotic training compared to conventional physiotherapy for ...
The current study used a convenience sample of 95 SRs included across seven overview topics to provide empirical evidence on issues surrounding quality assessments of SRs in overviews. This study found that AMSTAR assessments and inter-rater reliability were higher for Cochrane compared to non-Cochrane SRs; these results were consistent within each overview topic and for many of the individual questions of the AMSTAR tool. Minor challenges were encountered when assessing quality of SRs in the context of overviews, but decision rules were developed and recommendations for overview authors were provided. Results also suggested that inter-rater reliability of Cochrane and non-Cochrane SRs may be lower for SRs with moderate AMSTAR assessments and higher for SRs that were assessed as strong; inter-rater reliability may also be higher for non-Cochrane SRs assessed as weak. Consistent with a previous study [33], we found that the conclusions, but not the results, of Cochrane and non-Cochrane SRs ...
Introduction Dementia is the fastest growing major cause of disability globally and may have a profound impact on the health-related quality of life (HRQoL) of both the patient with dementia and those who care for them. This review aims to systematically identify and synthesise the measurements of HRQoL for people with, and their caregivers across the full spectrum of, dementia from its preceding stage of predementia to end of life.. Methods and analysis A systematic literature review was conducted in Medical Literature Analysis and Retrieval System Online , ExcerptaMedicadataBASE, Cochrane Database of Systematic Reviews , Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effect, National Health Service Economic Evaluation Database and PsycINFO between January 1990 and the end of April 2017. Two reviewers will independently assess each study for inclusion and disagreements will be resolved by a third reviewer. Data will be extracted using a predefined data ...
ORCID: 0000-0003-4326-2425 (2020) Current knowledge of the health and wellbeing harms experienced by victims of interpersonal violence: a scoping review protocol. In: Research at UCLan conference, 13 January 2020, University of Central Lancashire. ...
Therapeutic exercises play a crucial role in the management of burn injuries. The broad objective of this review is to systematically evaluate the effectiveness, safety and applicability to low-income countries of therapeutic exercises utilised by physiotherapists to improve function in patients with burns. Population = adults and children/adolescents with burns of any aspect of their bodies. Interventions = any aerobic and/or strength exercises delivered as part of a rehabilitation programme by anyone (e.g. physiotherapists, occupational therapists, nurses, doctors, community workers and patients themselves). Comparators = any comparator. Outcomes = any measure of outcome (e.g. quality of life, pain, muscle strength, range of movement, fear or quality of movement). Settings = any setting in any country. A systematic review will be conducted by two blinded independent reviewers who will search articles on PubMed, CiNAHL, Cochrane library, Medline, Pedro, OTseeker, EMBASE, PsychINFO and EBSCOhost using
OBJECTIVE: We examined how assessments of risk of bias of primary studies are carried out and incorporated into the statistical analysis and overall findings of a systematic review. DESIGN: A cross-sectional review. SAMPLE: We assessed 200 systematic reviews of randomised trials published between January and March 2012; Cochrane (n=100), non-Cochrane (Database of Reviews of Effects) (n=100). MAIN OUTCOMES: Our primary outcome was a descriptive analysis of how assessments of risk of bias are carried out, the methods used, and the extent to which such assessments were incorporated into the statistical analysis and overall review findings. RESULTS: While Cochrane reviews routinely reported the method of risk of bias assessment and presented their results either in text or table format, 20% of non-Cochrane reviews failed to report the method used and 39% did not present the assessment results. Where it was possible to evaluate the individual results of the risk of bias assessment (n=154), 75% (n=116/154) of
Interventions to improve adherence to lipid-lowering medication: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Interventions for treating fractures of the distal femur in adults: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Asthma is a highly prevalent condition that is the reason behind many morbidity and mortality cases in the world.1 2 Asthma management and control can be influenced, among other things, by the presence of other comorbid conditions.3-7 Our recently completed scoping review investigating the prevalence of comorbidities among patients with asthma identified a number of conditions including, but not limited to depression, anxiety, rhinitis, gastro-oesophageal reflux disease (GORD) and obesity, may occur more frequently in people with asthma than in those without, leading to potential additional difficulties in asthma management.8-10 It has been shown that health-related quality of life and daily-life functionality are diminished, and the use of healthcare services is increased with the presence of comorbid conditions.3 6 9-15 In addition, other studies showed that controlling these conditions at an early stage may improve asthma outcomes.6 12 14 15. These international studies focused on different ...
Review authors will work independently to assess risk of bias using criteria described in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2011) to assess trial quality. This set of criteria is based on evidence of associations between overestimate of effect and high risk of bias of the article such as sequence generation, allocation concealment, blinding, incomplete outcome data and selective reporting. If the raters disagreed, the final rating was made by consensus, with the involvement of another member of the review group. Where inadequate details of randomization and other characteristics of trials were provided, authors of the studies were contacted in order to obtain further information. Nonconcurrence in quality assessment was reported, but if disputes arose as to in which category a trial was to be allocated, again, resolution was made by discussion. The level of risk of bias was noted in both the text of the review and in the Summary of findings tables. ...
Design/methods A search of the literature will be conducted using relevant online databases. This will include all types of human studies that were published in English from the earliest record available to the first week of October 2013. One author will conduct the search and two independent authors will screen the titles and the abstracts identified by the search and critically appraise the selected papers. A third author will be available to resolve any disagreement. The findings will be reported according to Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. Critical appraisal as well as the level and the strength of evidence will follow the National Health and Medical Research Council (NHMRC) guidelines.. ...
The number of women who have had breast cancer is higher than ever before. These women may face many challenges when trying to assimilate back into life following their cancer diagnosis and treatment, and it is imperative to understand the long-term psychological consequences. This systematic review aims to provide a comprehensive overview of the associations between breast cancer history and mental health conditions.. Most reviews on the topic have been restricted to studying the prevalence of depression among cancer patients [15, 20]. We opted for considering a much broader list of mental disorders that have their onset during adulthood as outcomes, to give a more comprehensive picture of the spectrum of mental disorders that may affect breast cancer survivors. We also chose to include only studies in which a comparison group was available, so that the relative frequency or severity of these conditions compared to the general population could be studied.. We will include studies in which women ...
12-step Programs for Reducing Illicit Drug Use: Protocol for a Systematic Review Mette Deding, Madina Saidj, Lars Brännström, Margaretha Järvinen, Anne-Marie Klint Jørgensen & Maja Kärrman Fredriksson
This study supports the recommendations by Cochrane Collaboration to prioritize MEDLINE, EMBASE and CENTRAL as the basic databases for literature search to locate RCTs in the musculoskeletal area. Secondly, this study indicates that besides MEDLINE, EMBASE and CENTRAL a literature search to locate RCTs in the musculoskeletal area could also consider SCOPUS and CINAHL. Finally, this study indicates that even with the addition search of 10 other often used databases median recall is not improved noticeably.. Thirteen different databases were not enough to identify all relevant references. Searching MEDLINE, EMBASE and CENTRAL retrieved 88.9%, and searches in 10 additional databases increased the median recall by only 2 percentage point. Thus, results from this study could be interpreted, as an indication that searching databases is not sufficient to identify all relevant references and that other sources must be included in the literature search in order to achieve a larger recall. This study does ...
Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. ...
BACKGROUND: Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic
Accurate diagnosis, treatment and prevention of HIV and sexually transmitted infections (STIs) should be priorities for health systems around the world. Untreated or undertreated STIs can lead to infertility, cancer, chronic pelvic pain, and facilitate HIV transmission.1 New and existing treatments, tests and prevention strategies therefore need to be rigorously evaluated to assess their benefits and harms as this information is important for clinical decision-making and policy and guideline development. This editorial introduces the new Sexually Transmitted Infections Cochrane Review (STICR) group, which aims to support authors in summarising evidence about interventions and diagnostic tests used for genital tract infections.. The Cochrane Collaboration focuses on developing and maintaining systematic reviews of healthcare interventions to allow well-informed decisions about healthcare.2 A systematic review is an assessment and evaluation of all research studies that examine a particular ...
Systematic reviews can be used to inform decision making in many different disciplines, such as evidence-based healthcare and evidence-based policy and practice.[8] A systematic review can be designed to provide an exhaustive summary of current literature relevant to a research question. A systematic review uses a rigorous and transparent approach for research synthesis, with the aim of assessing and, where possible, minimizing bias in the findings. While many systematic reviews are based on an explicit quantitative meta-analysis of available data, there are also qualitative reviews and other types of mixed-methods reviews which adhere to standards for gathering, analyzing and reporting evidence.[9] Systematic reviews of quantitative data or mixed-method reviews sometimes use statistical techniques (meta-analysis) to combine results of eligible studies. Scoring levels are sometimes used to rate the quality of the evidence depending on the methodology used, although this is discouraged by the ...
TY - CONF. T1 - Operationalisation of realist synthesis as a PhD student; what works, for whom, and in what circumstances?. AU - Somervile, Susan. AU - Cooper, Christina. AU - Wilmot, Sarah. AU - Dalkin, Sonia. AU - Lhussier, Monique. PY - 2016/10/3. Y1 - 2016/10/3. N2 - Introduction: Operationalisation of realist methods can be challenging (Dalkin et al. 2015). Protocols and standards do exist in the literature to guide the process of realist informed research: Rycroft Malone et al (2012), Saul et al (2013), RAMESES (2013), Greenhalgh et al (2014) Blane et al (2015). However Realist methodologies are advocated for the exploration of complex interventions in a variety of subject areas and so are likely to require individually tailored approaches. This heterogeneity of process can affect the progress of novice realists, especially those who find themselves as doctoral students working more alone than is the norm in realist research. Objectives: This poster illustrates the approaches taken by ...
Clinical practice guidelines support optimal decision making in medical care. Guidelines should use the best available evidence.1 Systematic reviews use transparent criteria (such as Grading of Recommendations Assessment, Development and Evaluation (GRADE)) to evaluate the quality of evidence2 and so systematic reviews (where available) should be the primary source of evidence in guidelines. The Cochrane Collaboration produces systematic reviews (Cochrane Reviews) using a rigorous methodology. These are peer reviewed at the protocol and review stage, and are updated regularly.3 Previous work indicates that guidelines do not make full use of Cochrane Reviews.4 ,5 This represents research wastage, and may lead to suboptimal medical care.. Respiratory disease in children is common-20% of children visiting the emergency department, with a medical problem, will have a respiratory illness.6 However, the paediatric respiratory evidence base is limited. Nearly half of children with respiratory disease ...
Doan N, Ferro MA. Sleep duration and eating behaviours in youth: a scoping review protocol. BMJ Open, 2019, 9, e030457. PubMed. Ferro MA, Lipman EL, Van Lieshout RJ, Gorter JW, Shanahan L, Boyle M, Georgiades K, Timmons B. Multimorbidity in Children and Youth Across the Life-course (MY LIFE): protocol of a Canadian prospective study. BMJ Open, 2019, 9, e034544. Article. Kornelsen E, Buchan MC, Gonzalez A, Ferro MA. Hair cortisol concentration and mental disorder in children with chronic physical illness. Chronic Stress, 2019, 3, doi: 10.1177/2470547019875116.. Fayed N, Avery L, Davis AM, Streiner DL, Ferro M, Rosenbaum P, Cunningham C, Lach L, Boyle M, Glidden G, Ronen GM. Parent proxy discrepancy groups of quality of life in childhood epilepsy. Value in Health, 2019, 22(7), 822-828. PubMed. Petker TD, Halladay J, Vedelago L, Ferro MA, Tucker J, Goldman MS, Murphy JG, MacKillop J. Predictors of aging out of heavy episodic drinking in emerging adults: a systematic review protocol. Systematic ...
We identified 121 reports of network meta-analyses covering a wide range of medical areas. Key methodological components of the systematic review process were missing in most reports. The reporting did not differ by publication in a general or specialty journal or by public or private funding.. Several guidelines have been developed to assess the methodological quality and reporting of systematic reviews and meta-analyses,26 30 31 32 33 and according to all these guidelines, retrieving all relevant studies is crucial for the success of every systematic review. The literature search needs to be exhaustive and adequate to maximise the likelihood of capturing all relevant studies and minimise the effects of reporting biases that might influence the nature and direction of results.34 35 36 More than half of our network meta-analyses failed to report exhaustive searches; for those with adequate reporting, 11% searched only one electronic database (web table 6).. In addition, more than half of our ...
Cochrane database of systematic reviews (Online), COCHRANE DB SYST REV, Cohrane Database of Systematic Reviews, Medline Abbreviated Title: Cochrane Database Syst Rev, The Cochrane database of systematic reviews ...
How to develop a search strategy for a Cochrane Review A. GENERAL INFORMATION... 1 B. CHECKLIST FOR DEVELOPING A SEARCH STRATEGY... 2 C. DEVELOPING A SEARCH STRATEGY - A STEP BY STEP APPROACH... 3 D. EXAMPLES
It is well known that the Cochrane Database of Systematic Reviews is considered the gold standard for evidence-based medicine. Did you know Essential Evidence Plus from STAT!Ref includes the latest and most up-to-date summaries of systematic reviews from the Cochrane Library? Within EE+ you are able to access 5,800+ abstracts of Cochrane Systematic Reviews with…
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Many themes that Lorraine discussed were echoed in an excellent workshop in the Consumer Stream of the scientific program called, Stakeholder/consumer engagement in systematic reviews. Facilitators Dwayne Van Eerd and Emma Irvin of The Institute for Work and Health (IWH) presented a stakeholder engagement model and led a small but experienced group of consumers in an engaging discussion comparing the roles of Cochrane consumers and IWH stakeholders (a term preferred by IWH to consumer) in the systematic review process.. As many of us know, the main difference is that although some Cochrane Collaboration review groups use their consumers in a variety of roles including writing/editing plain language summaries and contributing to writing teams, the primary role of most of us is to provide comments for protocols and reviews in the draft stage. The IWH, on the other hand, utilizes its stakeholders throughout the entire review process including topic selection, research question refinement and ...
All countries face significant challenges from complex manifestations of malnutrition, which affects one in three people globally. Systematic reviews provide ready-to-use syntheses of quality-appraised evidence to inform decision-making for actions. To enhance the utility and quality of future Cochrane nutrition evidence, we described the scope and quality of all nutrition systematic reviews in the Cochrane Database of Systematic Reviews (CDSR). We screened all active CDSR records (31 July 2015) to identify reviews and protocols using pre-specified eligibility criteria and definitions. Duplicate, independent data extraction included criteria for inclusion of studies in completed reviews (PICOS). We assessed methodological quality (AMSTAR), use of GRADE, mapped reviews against 2013 Global Burden of Disease data, and categorised the paradigm (medical, lifestyle and socio-ecological) of the review question. We analysed our results using descriptive statistics. We screened 8484 records, and included 470 (8%
Systematic reviews (SRs) can help decision makers interpret the deluge of published biomedical literature. However, a SR may be of limited use if the methods used to conduct the SR are flawed, and reporting of the SR is incomplete. To our knowledge, since 2004 there has been no cross-sectional study of the prevalence, focus, and completeness of reporting of SRs across different specialties. Therefore, the aim of our study was to investigate the epidemiological and reporting characteristics of a more recent cross-section of SRs.We searched MEDLINE to identify potentially eligible SRs indexed during the month of February 2014. Citations were screened using prespecified eligibility criteria. Epidemiological and reporting characteristics of a random sample of 300 SRs were extracted by one reviewer, with a 10% sample extracted in duplicate. We compared characteristics of Cochrane versus non-Cochrane reviews, and the 2014 sample of SRs versus a 2004 sample of SRs. We identified 682 SRs, suggesting that more
The Cochrane review shows that rapid antigen tests are better at correctly identifying cases of COVID-19 in people with symptoms than in people without symptoms.
Browse by Topic lists topics, selected by the Cochrane Editorial Unit, which best reflects the content of an individual review, within a specialist interest. Reviews can appear in multiple topics, to cover the full interest of the review. This will assist users with locating a specific field of interest within a topic heading. Alternatively browse by Cochrane Review Group will display all the reviews published by that review group. Users will be able to locate a specific field of interest within a Cochrane Review Group heading. A full list of reviews is returned, with a highlighted review being the most significant review published at this time. The user can select by topic within the listing for more appropriate reviews for their needs, with the ability to look at reviews published within 3 months, up to 2 years, or all the reviews within the field of interest.
Browse by Topic lists topics, selected by the Cochrane Editorial Unit, which best reflects the content of an individual review, within a specialist interest. Reviews can appear in multiple topics, to cover the full interest of the review. This will assist users with locating a specific field of interest within a topic heading. Alternatively browse by Cochrane Review Group will display all the reviews published by that review group. Users will be able to locate a specific field of interest within a Cochrane Review Group heading. A full list of reviews is returned, with a highlighted review being the most significant review published at this time. The user can select by topic within the listing for more appropriate reviews for their needs, with the ability to look at reviews published within 3 months, up to 2 years, or all the reviews within the field of interest.
This project used multiple sources to draw together evidence and expertise in meta-narrative reviews. For each item we have included an explanation for why it is important and guidance on how it might be reported. Meta-narrative review is a relatively new method for evidence synthesis and as experie …
This paper provides a concise review of the efficacy, effectiveness and affordability of healthcare interventions to promote and assist tobacco cessation, in order to inform national guideline development and assist countries in planning their provision of tobacco cessation support.. To read the full abstract, and for information on how to access the full text, go to: http://dx.doi.org/10.1111/add.12998 or contact your DHB library, or organisational or local library for assistance.. West, R., et al. (2015). Healthcare interventions to promote and assist tobacco cessation: a review of efficacy, effectiveness and affordability for use in national guideline development. Addiction, 29 May [Epub before print].. ...
Network meta-analyses are increasingly used to determine the best available healthcare interventions among all existing treatments for one specific disease. We showed that the conduct, reporting and interpretation of network meta-analyses was questionable. Particularly, the search strategy, assessment of risk of bias and publication bias were inappropriate in most publications. Furthermore, we showed that treatment rankings usually reported with no credibility interval have a substantial degree of imprecision, with a 50% or greater probability that the best-ranked treatment was actually not the best in 28% of networks. We also investigated whether conventional meta-analyses meet clinicians and patients needs. Our results revealed a substantial waste of research, with more than 40% of treatments, treatment comparisons, and trials not covered by existing systematic reviews. We developed a new paradigm, the live cumulative network meta-analysis, a single network meta-analysis covering all ...
Updated: Jan 7 2020 Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: an overview of Cochrane Reviews PMID 29084357 https://doi.org/10.1002/14651858.CD012509.pub2 Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews PMID 26461263 https://doi.org/10.1002/14651858.CD011407.pub2 Antidepressants for neuropathic pain PMID 17943857 https://doi.org/10.1002/14651858.CD005454.pub2 Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults PMID 23797674 https://doi.org/10.1002/14651858.CD010608 Antipsychotics for acute and chronic pain in adults PMID 23990266 https://doi.org/10.1002/14651858.CD004844.pub3 As required versus fixed schedule analgesic administration for postoperative pain in children PMID 25719451 https://doi.org/10.1002/14651858.CD011404.pub2 Bisphosphonates for the relief of pain secondary to bone ...
Here we summarise our thinking behind the items in AMSTAR 2, which are numbered as in the instrument (see supplementary figure). Supplementary appendix 1 provides a more complete users guide.. 1. Did the research questions and inclusion criteria for the review include the components of PICO?. It is common practice to use the PICO description (population, intervention, control group, and outcome) as a convenient and easily memorised framework for a study question. Sometimes a timeframe should be added if this is critical in determining the likelihood of a study capturing relevant clinical outcomes (eg, an effect of the intervention is only expected after several years).. 2. Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significantdeviations from the protocol?. Systematic reviews are a form of observational research, and the methods for the review should be agreed on before the ...
This webinar is the fifth in a series that Cochrane Learning Live is running in partnership with GESI: the Global Evidence Synthesis Initiative.. Rapid reviews are a type of knowledge synthesis for which the steps of a systematic review are streamlined or accelerated to produce evidence in a shortened timeframe. In this webinar, Dr Andrea C. Tricco and Dr Etienne V. Langlois will outline the usefulness of rapid reviews for providing actionable and relevant evidence to make informed decisions, describe how to engage knowledge users (e.g. patients, healthcare providers, policy-makers) in the conduct of rapid reviews, and discuss different rapid review methods that can be used in various contexts. Prof John Lavis will describe similarities and differences across a range of EVIPNet-affiliated rapid evidence services and provide examples of how theyve evolved over time in response to their experiences working with health-system policymakers and stakeholders.. This webinar is for anyone interested in ...
Just off the press: Cochrane Collaboration Review of the use of therapeutic hypothermia after cardiopulmonary resuscitation. Evidence of moderate quality suggests that conventional cooling methods provided to induce mild therapeutic hypothermia improve neurological outcome after cardiac arrest, specifically with better outcomes than occur with no temperature management The updated Cochrane review goes a long way…
Background Primary study selection between systematic reviews is inconsistent, and reviews on the same topic may reach different conclusions. Our main objective was to compare systematic reviews on...
The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committees 11 prioritized health endpoints- therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances ...
This systematic review shows that despite several limitations, there is epidemiologic evidence to support an association between NAFLD or NASH and an increased risk of HCC; risk seems to be limited to individuals with cirrhosis.
Background: Frequently, interventions for a given health problem have never been compared in head-to-head randomized controlled trials. In this context, adjusted indirect comparisons based on network meta-analyses (NMAs) could answer the question posed by most healthcare professionals: what is the best intervention among the existing interventions for a specific condition? Objectives: To evaluate the trend in NMAs publication topic in medical electronic databases and in the top five impact factor journals in the Medicine, General and Internal category. Methods: A search strategy was performed in Medline (PubMed), EMBASE, and CENTRAL, since inception (Figure 1). We analysed the general yearly trend all together and separately by database and by journal. Results: During the analysed period, the reporting of studies mentioning NMA has increased since the beginning of the XXI century and markedly since 2009. EMBASE was the database with the highest cumulative number of references bout NMA and the ...
Our work involves preparing, maintaining and promoting systematic reviews on:. · the diagnosis and treatment of adults with malignant haematological disorders. · the treatment and management of people with acquired haematological disorders · blood and stem cell donation. · use of stem cell therapies and haematopoietic growth factors. · blood transfusion and its alternatives. We are one of the 53 Cochrane Review Groups (https://www.cochrane.org/about-us/our-global-community) which are part of Cochrane, an international not-for-profit and independent organisation, dedicated to making up-to-date, accurate information about the effects of healthcare readily available worldwide. Cochrane produces and disseminates systematic reviews of healthcare interventions, and promotes the search for evidence in the form of clinical trials and other studies of interventions. The Cochrane Haematology editorial base is located at the University Hospital of Cologne, Department of Internal Medicine (Haematology ...
Aims To give an updated perspective of interventions from additional data collected since our first review, conducted in 2008. Background This updated Cochrane Review incorporates new information from recent randomized controlled trials on culturally appropriate diabetes health education interventions. Methods An electronic literature search of six databases was repeated, with databases of ongoing trials checked and three journals hand-searched. Meta-analysis was carried out for sufficiently homogeneous outcomes, and common themes among trials were highlighted. Results A total of 22 new trials were added to the original 11. Meta-analysis of 28 trials containing suitable data showed significant improvements in glycaemic control (HbA1c) and diabetes knowledge over a period of 24 months, after the delivery of culturally appropriate education to participants, compared with those receiving conventional care. There were no consistent benefits over the control group in other selected outcome ...
Medical day hospitals provide multidisciplinary health services to older people in one location. In this Cochrane review, the authors investigated their effectiveness in preventing death, disability, institutionalisation and improving subjective health status.. Sixteen randomised and quasi-randomised trials ... compared day hospitals with comprehensive care (five trials), domiciliary care (seven trials) or no comprehensive care (four trials). The authors conclude from their analysis that there is low quality evidence that medical day hospitals appear effective compared to no comprehensive care for the combined outcome of death or poor outcome, and for deterioration in [activities of daily living ]. There is no clear evidence for other outcomes, or an advantage over other medical care provision.. This article can be read in free full text at: http://dx.doi.org/10.1002/14651858.CD001730.pub3. Brown L, Forster A, Young J, Crocker T, Benham A, Langhorne P, Day Hospital Group. (2015). Medical ...
Antibiotic treatments are indispensable for human and animal health. However, the heavy usage of antibiotics has led to the emergence of resistance. Antibiotic residues, antibiotic-resistant bacteria and genes are introduced into the terrestrial and aquatic environments via application of human and animal wastes. The emergence and the spread of antibiotic resistance in environmental reservoirs (i.e., soil, water, wildlife) threatens the efficacy of all antibiotics. Therefore, there is an urgent need to determine what effective solutions exist to minimize the dissemination of antibiotic resistance in the environment. The aim of this article is to describe the protocol of a systematic review of the literature considering these solutions. The primary questions addressed by the systematic review protocol are: how antibiotic resistance in the environment is impacted by changes in practice concerning (i) the use of antibiotics, (ii) the management of wastes or (iii) the management of the natural compartment.
Strontium and magnesium doped lanthanum gallate La0.85Sr0.15Ga0.85Mg0.15O3-delta (LSGM) oxygen ionic conducting ceramics were prepared by a steric entrapment synthesis (SES) method, which is a polymeric precursor synthesis method by using polyvinyl alcohol in aqueous solution. The perovskite LSGM phase formed essentially at a calcination temperature of 900 degrees C. Pure and single perovskite LSGM phase with high relative density of 97.1% was obtained after sintering at 1450 degrees C, while the relative density of the LSGM sample sintered at the same temperature by solid state reaction (SSR) method was 80.6% in present experiment. Comparing with SSR synthesis method, the sintering temperature by SES can be reduced at least 100 degrees C. Impedance spectra revealed that the grain-boundary resistivity of LSGM synthesized by SES was smaller than that by SSR method. and the conductivities of the samples by SES were higher than those by SSR method at all measuring temperatures.. ...
The Cecil G. Sheps Center for Health Services Research seeks to improve the health of individuals, families, and populations by understanding the problems, issues and alternatives in the design and delivery of health care services.. ...
BACKGROUND: Although many machine learning algorithms have been developed to detect anterior cruciate ligament (ACL) injury based on magnetic resonance imaging (MRI), the performance of different algorithms required further investigation. The objectives of this current systematic review are to evaluate the diagnostic accuracy of machine-learning-assisted detection for ACL injury based on MRI and find the current best algorithm. METHOD: We will conduct a comprehensive database search for clinical diagnostic tests in PubMed, EMBASE, Cochrane Library, and Web of science without restrictions on publication status and language. The reference lists of the included articles will also be checked to identify additional studies for potential inclusion. Two reviewers will independently review all literature for inclusion and assess their methodological quality using Quality Assessment of Diagnostic Accuracy Studies version 2. Clinical diagnostic tests exploring the efficacy of machine-learning-assisted ...
Whether overweight or obese end stage renal disease (ESRD) patients are suitable for renal transplantation (RT) is often debated. The objective of this review and meta-analysis was to systematically investigate the outcome of low versus high BMI recipients after RT. Comprehensive searches were conducted in MEDLINE OvidSP, Web of Science, Google Scholar, Embase, and CENTRAL (the Cochrane Library 2014, issue 8). We reviewed four major guidelines that are available regarding (potential) RT recipients. The methodology was in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and written based on the PRISMA statement. The quality assessment of studies was performed by using the GRADE tool. A meta-analysis was performed using Review Manager 5.3. Random-effects models were used. After identifying 5,526 studies addressing this topic, 56 studies were included. We extracted data for 37 outcome measures (including data of more than 209,000 RT recipients), of which 26 could be meta
Whether overweight or obese end stage renal disease (ESRD) patients are suitable for renal transplantation (RT) is often debated. The objective of this review and meta-analysis was to systematically investigate the outcome of low versus high BMI recipients after RT. Comprehensive searches were conducted in MEDLINE OvidSP, Web of Science, Google Scholar, Embase, and CENTRAL (the Cochrane Library 2014, issue 8). We reviewed four major guidelines that are available regarding (potential) RT recipients. The methodology was in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and written based on the PRISMA statement. The quality assessment of studies was performed by using the GRADE tool. A meta-analysis was performed using Review Manager 5.3. Random-effects models were used. After identifying 5,526 studies addressing this topic, 56 studies were included. We extracted data for 37 outcome measures (including data of more than 209,000 RT recipients), of which 26 could be meta
Since 1994, the CIDG has been preparing systematic reviews on the benefits and harms of healthcare interventions for infectious diseases, particularly malaria, tuberculosis, diarrhoea, and tropical diseases. As of 2015, we now also manage the HIV/AIDS portfolio of reviews.. Over the years the Groups name has changed to reflect the expansion of its scope: Parasitic Diseases Group (1994 to 1995); Tropical Diseases Group (1996 to 1997); and Infectious Diseases Group (1997 to present). The CIDG, which is supported by the UK Foreign, Commonwealth and Development Office (FCDO) through the Research, Evidence and Development Initiative (READ-It) programme aims to ensure that healthcare diseases and healthcare delivery related to low- and middle-income countries are included in the brief of Cochrane, and that people from these countries are involved in preparing Cochrane Reviews.. The CIDGs main areas of work are on determination of the effects of interventions on the prevention or treatment infectious ...
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How safe is it for anyone else? The second hit on Google scholar addresses that. Its a review paper which is good because systematic reviews are at the top of the hierarchy of evidence. I keep telling you that you shouldnt trust just one source of evidence, even a well-conducted scientific study. A systematic review gathers together all the scientific studies on a particular topic, weights them according to how well-conducted and therefore reliable they are, and weighs up the balance of evidence from all the available research. So a good, recent systematic review is about as dependable evidence as you can ask for. This review is called Aspartame: review of safety and again all you can see is the abstract unless you pay for the full paper. It was published in 2002 which isnt bang up to date but its not really old either. It was published in Regulatory Toxicology and Pharmacology which Wikipedia tells me is a peer reviewed journal with an impact factor of 2.132 which isnt terriible for a ...
How safe is it for anyone else? The second hit on Google scholar addresses that. Its a review paper which is good because systematic reviews are at the top of the hierarchy of evidence. I keep telling you that you shouldnt trust just one source of evidence, even a well-conducted scientific study. A systematic review gathers together all the scientific studies on a particular topic, weights them according to how well-conducted and therefore reliable they are, and weighs up the balance of evidence from all the available research. So a good, recent systematic review is about as dependable evidence as you can ask for. This review is called Aspartame: review of safety and again all you can see is the abstract unless you pay for the full paper. It was published in 2002 which isnt bang up to date but its not really old either. It was published in Regulatory Toxicology and Pharmacology which Wikipedia tells me is a peer reviewed journal with an impact factor of 2.132 which isnt terriible for a ...