Retinoid X Receptor alpha Antibody (1G1): H00006256-M17 by Novus Biologicals at Labscoop.com - Read reviews, citations, datasheets, protocols & more.
Retinoid X nuclear receptors (RXRs) are ligand-dependent transcriptional modulators that execute their biological action through the generation of functional heterodimers. Biochemical data indicate that, in the absence of ligand, RXR can exist as an inactive tetramer and that its dissociation, induced by ligand, is important for receptor activation. When RXRa is freed from the tetramer, it forms heterodimers with obligated partners such as RAR, which are protective in cancer. The RXR-tetramer interface is assembled from amino acids that are conserved across several closely related receptors. A single point mutation on RXRa, S427F, which is found in 5% of patients with bladder cancer, is located exactly at the tetramerization interface; however its mechanism of action is unknown. To understand the effect of S427F mutation on the stability of the RXRa tetramer, we performed MD simulations ...
Rabbit recombinant monoclonal Retinoid X Receptor alpha antibody [EPR7106] validated for WB, IP, ICC and tested in Human, Mouse and Rat. With 3 independent…
Theoretical study of molecular mechanism of binding TRAP220 coactivator to Retinoid X Receptor alpha, activated by 9-cis retinoic acidKurcinski, M. & Koliński, A.The Journal of Steroid Biochemistry and Molecular Biology 121, 124-9, 2010. ...
Cusabio offers RXRA related Antibodies, Proteins, cDNA and ELISA Kits. We also illustrate the related signaling pathways covering most research areas so that you can know the internal cellular communication. Some free antibody samples are given away in times.
In an analysis of the Breast International Group (BIG) 1-98 trial reported in the Journal of Clinical Oncology, Chirgwin et al found that poorer adherence to endocrine therapy was associated with poorer disease-free survival in postmenopausal women with hormone receptor-positive breast cancer receiving adjuvant tamoxifen, letrozole, or sequential letrozole/tamoxifen or tamoxifen/letrozole for 5 years.. Study Details. The study analyzed the effects of early cessation of treatment (, 36 months vs ≥ 36 months) and treatment compliance score , 90% on disease-free survival among 6,144 patients receiving at least one dose of study drug. Compliance was defined as taking at least 80% of pills in a drug pack with no breaks longer than 1 week.. Effects of Lower Adherence. On multivariate analysis, early cessation of letrozole (hazard ratio [HR] = 1.45, P = .01), tamoxifen/letrozole (HR = 1.56, 95% confidence interval [CI] = 1.21-2.01), and letrozole/tamoxifen (HR = 1.57, 95% CI = 1.21-2.03) were ...
p,Study on molecular mechanism of conformational reorientation of RXR-alpha ligand binding domain is presented. We employed CABS-a reduced model of protein dynamics to model folding pathways of binding 9-cis retinoic acid to apo-RXR molecule and TRAP220 peptide fragment to the holo form. Based on obtained results we also propose a sequential model of RXR activation by 9-cis retinoic acid and TRAP220 coactivator. Methodology presented here may be used for investigation of binding pathways of other NR/hormone/cofactor sets.,/p,. ...
Purpose: : In many retina neurodegenerative diseases, photoreceptors (PRs) progressively degenerate by apoptosis causing visual loss. We demonstrated that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes the survival of rat retina PRs during early development in vitro and upon oxidative stress by activating the ERK/MAP kinase signaling pathway. We have now investigated upstream this pathway, to establish whether DHA acts indirectly, modifying membrane properties to induce the activation of tyrosine kinase receptors (TRK) or directly, acting as a ligand for retinoid X receptors (RXR), as has been shown in the brain. We have also evaluated whether DHA has to be released from membrane phospholipids to exert its protective effect. Methods: : We prepared pure retinal neuronal cultures, supplemented or not with DHA, and incubated for 6 days or treated at day 3 with oxidants paraquat (PQ) or H2O2. To investigate activation of TRK and RXR, prior to DHA addition we ...
Mammalian cardiomyocytes undergo cell division only during embryonic development. This process can be disturbed by many gene mutations, resulting in myocardial hypoplasia Retinoic acid (RA), the biologically active derivative of vitamin A, is an important morphogen during development. Deficiency in vitamin A by dietary deprivation and mutation in Rxra, a nuclear receptor for retinoic acid, will lead to embryonic myocardial hypoplasia. It has been demonstrated that Rxra acts in the epicardium, a thin layer of cells enveloping the myocardium, to influence myocardium proliferation. Previous studies suggested that RXRA induces the secretion of mitogenic factors from the epicardium. In this study, we found that AGN193109, an RA antagonist, and retinoic acid have no effect on the production of mitogenic activity from a rat epicardial cell line, EMC, a mouse epicardial cell line, MEC1, or primary epicardial cells from chick embryos. Rxra knockdown via adenovirus-mediated RNAi does not reduce the ...
Methods The model of hypoxia/reoxygenation (H/R) injury was established through hypoxia for 6 h and reoxygenation for 4 h in cardiomyocytes of H9c2, We measured the survival rate by Typan blue exclusion, apoptosis rate of cardiomyocytes by FACS analysis, and mitochondrial membrane potential by JC-1 fluorescent probe. All measurement data were expressed as mean±SD of mean, and statistically analysed using one-way ANOVA analysis and Dunnett test. Differences were considered significant when P was,0.05.. ...
Rabbit polyclonal Retinoid X Receptor gamma antibody validated for WB, IHC, ICC/IF and tested in Human, Mouse and Rat. Referenced in 4 publications and 7…
C. N. Cavasotto, Liu, G., James, S. Y., Hobbs, P. D., Peterson, V. J., Bhattacharya, A. A., Kolluri, S., Zhang, X. -kun, Leid, M., Abagyan, R., Liddington, R. C., and Dawson, M. I., "Determinants of Retinoid X Receptor Transcriptional Antagonism", Journal of Medicinal Chemistry, vol. 47, no. 18, pp. 4360 - 4372, 2004. ...
C. N. Cavasotto, Liu, G., James, S. Y., Hobbs, P. D., Peterson, V. J., Bhattacharya, A. A., Kolluri, S., Zhang, X. -kun, Leid, M., Abagyan, R., Liddington, R. C., and Dawson, M. I., "Determinants of Retinoid X Receptor Transcriptional Antagonism", Journal of Medicinal Chemistry, vol. 47, no. 18, pp. 4360 - 4372, 2004. ...
This phase I study has defined a clinically active and tolerable dose of bexarotene for patients with non-M3 AML. Importantly, we identified no severe DLTs in this population. In addition, we identified laboratory and clinical evidence of differentiation of non-M3 myeloid leukemic cells in response to retinoid X receptor activation as well as evidence of clinical response in chemotherapy refractory non-M3 AML. The findings establish retinoid X receptor agonists as a novel class of therapeutic agents for the treatment of non-M3 AML.. This trial has identified 300 mg/m2 as the maximum patient tolerable dose for bexarotene in patients with AML. Our study was originally done in a phase I format to identify AML-specific side effects of bexarotene that might reduce the standard treatment dose. In previous phase I and II studies in patient with cutaneous T-cell lymphoma and solid tumors, bexarotene was tested up to 600 mg/m2 and found to be safe but difficult to tolerate (9, 15). In addition, in a ...
Receptors for retinoic acid act as ligand activated transcription factors. The three-dimensional structure of the retinoid X receptor (RXR) ligand binding domain has been determined, but little information is available concerning the properties of the protein in solution. Hydrogen/deuterium exchange followed by electrospray ionization mass spectrometry was used to probe the solution conformation of the recombinant human RXRalpha homodimer ligand binding domain in the presence and absence of 9-cis-retinoic acid (9-cis-RA). Within the experimental time domain (0.25-180 min), about 20 amide hydrogens showed decreased exchange rates in the presence of saturating concentrations of 9-cis-RA as compared to those found for the homodimer in the absence of ligand. Most of the amides were located in peptides derived from regions of the protein shown by the X-ray structure to interact with the bound ligand: the amino termini of helices 3 and 9, the two beta sheets, helix 8, the H8-H9 loop, and the carboxyl terminus
A. H. sampsonii: (a) habit; (b) sepal; (c) petal; (d) capsule. B. H. assamicum: (e) habit; (f) sepal; (g) petal; (h) capsule (a, e x 2/3; rest x 6). A. Fan 39, except (d) Faurie 175. B. Simon 180.. ...
Hypericum sampsonii is a PERENNIAL growing to 0.6 m (2ft). It is hardy to zone (UK) 9. It is in flower from Jul to August, and the seeds ripen from Aug to October. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.The plant is self-fertile. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils and prefers well-drained soil. Suitable pH: acid, neutral and basic (alkaline) soils. It can grow in semi-shade (light woodland) or no shade. It prefers moist soil.
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Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene. This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Retinoid X receptor Retinoid X receptor gamma has been shown to interact with ITGB3BP. GRCh38: Ensembl release 89: ENSG00000143171 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000015843 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". ...
Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). miRNA has-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA has-miR-613. The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with ...
DataMed is a prototype biomedical data search engine. Its goal is to discover data sets across data repositories or data aggregators. In the future it will allow searching outside these boundaries. DataMed supports the NIH-endorsed FAIR principles of Findability, Accessibility, Interoperability and Reusability of datasets with current functionality assisting in finding datasets and providing access information about them.
Wiki-Pi: a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.
Wiki-Pi: a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.
BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid × receptor a (RXRa) are involved in hepatocellular carcinogenesis ...
All-trans retinoic acid (ATRA) triggers a wide range of effects on vertebrate development by regulating cell proliferation, differentiation, and apoptosis. ATRA activates retinoic acid receptors (RARs) which heterodimerize with retinoid X receptors (RXRs). RAR/RXR heterodimers function as ATRA-dependent transcriptional regulators by binding to retinoic acid response elements (RAREs). To identify RAR/RXR heterodimer-binding sites in the human genome, we performed a modified yeast one-hybrid assays and identified 193 RAR/RXR heterodimer-binding fragments in the human genome. The putative target genes included genes involved in development process and cell differentiation. Gel mobility shift assays indicated that 160 putative RAREs could directly interact with the RAR/RXR heterodimer. Moreover, 19 functional regulatory single nucleotide polymorphisms (rSNPs) on the RAR/RXR-binding sequences were identified by analyzing the difference in the DNA-binding affinities. These results provide insights into the
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRα, RXRβ, RXRγ). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin D receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models ...
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to study the mechanism underlying nuclear receptor retinoid x receptor et (RXR-alpha)-mediated pathways on regulating S-adenosyl-L-methionine (SAMe) homeostasis. The main hypothesis is that RXR-alpha-mediated pathways either directly or indirectly control SAMe synthesis and alter the levels of glutathione and phosphatidylcholine in the liver, which consequently play a crucial role in the development of alcoholic liver disease (ALD). Most of the retinol and alcohol studies rely on either feeding animals with excess amount of retinoids or introducing animals with retinol deficient diet. Feeding animals with retinoids can be toxic. Retinol deficiency can also cause many unwanted effects. Knockout technology avoids these potential problems. Tissue specific knockout further allows studying the function of the gene in a cell type specific manner without affecting the gene function systemically. We have established an animal ...
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Surgery is the only potentially curative method for patients with gastric cancer. The ideal surgical resection not only achieves the curative intent but also decreases postoperative morbidity and mortality. The long-term prognosis and postoperative quality of life should both be of great concern [12, 16, 17]. Considering that distal subtotal gastrectomy is associated with a better quality of life and lower morbidity and mortality, many surgeons recommend distal subtotal gastrectomy as the optimal procedure for lower-third gastric cancer based on previous reports [18-20]. However, at the moment, there is no consensus regarding the best extent of gastrectomy for middle-third gastric cancer. The only prospective randomized trial, performed in Italy, compared surgical morbidity and long-term prognosis between distal subtotal gastrectomy and total gastrectomy for patients with gastric cancer. However, only approximately 20% of patients in that study had middle-third gastric cancer [10, 21]. The ...
Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as conditional heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. RAR and RXR ligands are known to play role in reprogramming several tumour cells, and thus the development of appropriate ligands with reduced teratogenic and other side effects are still highly required. In this study, we have investigated expression pattern of retinoid receptor subtypes (RARalpha, RARbeta, RARgamma) and retinoid X nuclear receptor subtypes (RXRalpha, RXRbeta, RXRgamma) in three different human organ malignancies, i) thyroid papillary carcinoma, ii) breast cancer, and iii) renal carcinoma.. ...
Looking for online definition of Retinoid X-receptor in the Medical Dictionary? Retinoid X-receptor explanation free. What is Retinoid X-receptor? Meaning of Retinoid X-receptor medical term. What does Retinoid X-receptor mean?
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described ...
Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008 Nov 15;181(10):7176-7185 ...
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Deregulated signal transduction is a major facet of cancer development and progression. Herein, we review the current paradigm for retinoic acid signaling, its role in ca..
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What does Medical & Science Rxr stand for? Hop on to get the meaning of Rxr. The Medical & Science Acronym /Abbreviation/Slang Rxr means Receptor X Receptor. by AcronymAndSlang.com
Define 13-cis-retinoic acid. 13-cis-retinoic acid synonyms, 13-cis-retinoic acid pronunciation, 13-cis-retinoic acid translation, English dictionary definition of 13-cis-retinoic acid. n. A synthetic isomer of retinoic acid that inhibits sebaceous gland secretion and is used in the treatment of severe nodular acne. It can cause birth...
OADs with significant Cardio-protective benefits, improving whole body insulin sensitivity with improvement in muscle endurance.. Connexios program comprises unique and selective rexinoid agonists with Pan-PPAR activation across multiple tissues with a clean demonstrated safety profile. The lead candidate has been shown to regulate multiple target genes through selected heterodimer partners, resulting in widespread physiological benefits. Retinoid X Receptor (RXR) functions as a heterodimeric partner to several other nuclear receptors and regulates intracellular receptor signaling pathways involved in, among others, glucose and lipid metabolism and therefore has potential to impact multiple risk factors associated with the metabolic syndrome. Selective activation of RXR heterodimers can address critical dysregulations that underlie cellular pathology in key tissues observed in T2DM and metabolic syndrome.. As a potent agonist of RXR isoforms α, β and γ, CNX-013-B2 transactivates the three ...
Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase response (APR). Retinoid X receptor α (RXRα), the most highly expressed RXR isoform in liver, plays a central role in regulating bile acid, cholesterol, fatty acid, steroid and xenobiotic metabolism and homeostasis. Many of the genes regulated by RXRα are repressed during the negative hepatic APR, although the underlying mechanism is not known. We hypothesized that inflammation-induced alteration of the subcellular location of RXRα was a common mechanism underlying the negative hepatic APR. Nuclear RXRα protein levels were significantly reduced (~50%) within 1-2 hours after low-dose LPS treatment and remained so for at least 16 hours. RXRα was never detected in cytosolic extracts from saline-treated mice, yet was rapidly and profoundly detectable in the cytosol from 1 hour, to at least 4 hours,
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