The transcription factor DRTF1/E2F is implicated in the control of cellular proliferation due to its interaction with key regulators of cell cycle progression, such as the retinoblastoma tumour suppressor gene product and related pocket proteins, cyclins and cyclin-dependent kinases. DRTF1/E2F DNA binding activity arises when a member of two distinct ... read more families of proteins, DP and E2F, interact as DP/E2F heterodimers. Here, we report the isolation and characterisation of a new member of the E2F family of proteins, called E2F-5. E2F-5 was isolated through a yeast two hybrid assay in which a 14.5 d.p.c. mouse embryo library was screened for molecules capable of binding to murine DP-1, but also interacts with all known members of the DP family of proteins. E2F-5 exists as a physiological heterodimer with DP-1 in the generic DRTF1/E2F DNA binding activity present in mammalian cell extracts, an interaction which results in co-operative DNA binding activity and transcriptional activation ...
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... , Authors: Roderick AF MacLeod, Stefan Nagel. Published in: Atlas Genet Cytogenet Oncol Haematol.
Plasmid pGL3-Control-E2F-3UTR-WT from Dr. Joshua Mendells lab contains the insert E2F transcription factor 1 and is published in Nature. 2005 Jun 9. 435(7043):839-43. This plasmid is available through Addgene.
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Chao, P-Z., Hsieh, M-S., Cheng, C-W., Hsu, T. J., Lin, Y. T., Lai, C. H., Liao, C. C., Chen, W-Y., Leung, T-K., Lee, F-P., Lin, Y-F. & Chen, C-H., 2015, 於 : Oncotarget. 6, 1, p. 159-170 12 p.. 研究成果: 雜誌貢獻 › 文章 ...
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p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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Complete information for E2F5 gene (Protein Coding), E2F Transcription Factor 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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