Characterization of the innate immune response to chronic aspiration in a novel rodent model.s profile, publications, research topics, and co-authors
Whether the conical cuff shape of the tracheal tube is efficient in reducing microaspiration of contaminated oropharyngeal and gastric secretions is unknown. Previous clinical studies reported conflicting results [24, 25] and had several limitations, precluding any definite conclusion. Our study is sufficiently powered to detect a significant difference in microaspiration of gastric contents between patients intubated with conical-cuffed tracheal tube and those intubated with standard-cuffed tracheal tubes. One of the strengths of this study is the use of quantitative measurement of pepsin as a marker of microaspiration. Pepsin is probably the most accurate, currently available, marker for microaspiration [9]. Whereas technetium-99 is the gold standard for the diagnosis of microaspiration of gastric contents [35], its use is not allowed outside the Radiology Department. The transport of critically ill patients outside the ICU has a considerable potential for misadventure and could be a ...
Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF.. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in patients with IPF.. Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and inflammation are markers of microaspiration in IPF.. Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary function.. Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e. unscheduled clinic visit, emergency room visit, or hospitalization). ...
James L. Coyle will present on the penetration-aspiration (PA) scale at ASHAs Health Care Connect, to be held July 7-9 in New Orleans.. A new feature of the conference is combination lecture-lab sessions. In his combined session, "Using the Penetration-Aspiration Scale," Coyle will introduce the scale and provide examples of scoring decision-making.. He will then lead a hands-on learning lab in which participants review examples of different PA scores and practice using the scale to assess videofluoroscopic data.. Coyle will also present "Screening, Assessment and Management of Oral Colonization in the ICU," which explores clinical decision-making and oral health in intensive care units.. Health Care Connect, co-located with Schools Connect and Private Practice Connect, is designed specifically for clinicians in health care settings. Attendees may attend sessions at any of the three conferences.. ...
Penetration-aspiration scale (PAS) and swallowing performance score (SPS) determined via MBS. Twenty-four (42%) patients had a PAS score over 6, implying aspira
The human small intestine plays a central role in the processes of digestion and nutrient absorption. However, characterizations of the human gut microbiome have largely relied on stool samples, and the associated methodologies are ill-suited for the viscosity and low microbial biomass of small intestine samples. As part of the REIMAGINE study to examine the specific roles of the small bowel microbiome in human health and disease, this study aimed to develop and validate methodologies to optimize microbial analysis of the small intestine. Subjects undergoing esophagogastroduodenoscopy without colon preparation for standard of care were prospectively recruited, and ~ 2 ml samples of luminal fluid were obtained from the duodenum using a custom sterile aspiration catheter. Samples of duodenal aspirates were either untreated (DA-U, N = 127) or pretreated with dithiothreitol (DA-DTT, N = 101), then cultured on MacConkey agar for quantitation of aerobic gram-negative bacteria, typically from the class
Objective: To explore the effect of minimally invasive hematoma aspiration (MIHA) on the c-Jun NH2-terminal kinase (JNK) signal transduction pathway after intracerebral hemorrhage (ICH). Methods: In this experiment, 300 adult male Wistar rats were randomly and averagely divided into sham-operated group, ICH group and MIHA group. In each group, 60 rats were used in the detection of indexes in this experiment, while the other 40 rats were used to replace rats which reached the exclusion criteria (accidental death or operation failure). In ICH group and MIHA group, ICH was induced by injection of 70 µL of autologous arterial blood into rat brain, while only the rats in MIHA group were treated by MIHA 6 h after ICH. Rats in sham-operated group were injected nothing into brains, and they were not treated either, like rats in ICH group. In each group, six rats were randomly selected to observe their Bedersons scales persistently (6, 24, 48, 72, 96, 120 h after ICH). According to the time they were
Patients with a ST-elevation Myocardial Infarction documented in an ambulance or in a Cathlab with ≥2 mm ST segment elevation in at least two contiguous leads, presenting in the Cathlab ,12 hours after the onset of symptoms lasting ≥20 min and having an angiographical visible stenosis (,30%) or TIMI≤ II in de-novo, native, previously unstented vessel ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Aspiration Control Systems Market report provides a basic overview of the industry including definitions, classifications, Aspiration Control Systems market by applications and industry chain structure. The report on Aspiration Control Systems market analysis is provided for the international Aspiration Control Systems industry including development history, competitive landscape analysis & Key players in all major regions with development status of this industry.. For More Information Browse the Aspiration Control Systems Market report with TOC, Table & figures @ https://www.360marketupdates.com/10435387. Aspiration Control Systems Market report focuses on in depth analysis of the current status of Aspiration Control Systems industry. The study of Aspiration Control Systems industry is very significant to improve business productivity and for the study of market forecast. The Aspiration Control Systems ...
It was clear that the percentage of plants growth was too low in AlDwahriya village compared to Fida village; As a result of this, we decided to study the issue. Samples had been taken from the two villages by taking samples from water protocol (water used in crops irrigation). Other samples had been taken from soil protocol (soil used in agriculture). Water protocol and soil protocol were applied in school laboratory to measure the properties of salinity, conductivity and acidity. They applied them to the soil and water samples in two different areas ...
My Johnnie aspirates all the time. Thankfully he has only had full blown Pneumonia 4 times and not for months now! Knock on wood! He to had the swallow study and it only showed a slight delay in swallow but no aspiration on swallow. We still have not been able to get in to see the pulmo either. He did need some heavy antibiotics for the full on pneumonia, so if they arent giving him the antibiotics you will want to call them. He is on Pulmicort twice daily as a preventive and then albuterol nebulizer treatments as needed. If its really bad we sometimes have to do back to back treatments of albuterol. The one thing that keeps it at bay is movement. As soon as he stops moving around, (naps, bedtime, sitting in car seat) his lungs fill up with fluid and he has to move around and cough to clear his lungs. We were on a long road trip yesterday, 17 hours in the car seat, and even though he is upright, he still had a horrible time clearing his lungs. He has not had an episode where he just stopped ...
This trial is investigating the efficacy and tolerability of olmesartan medoxomil in hypertensive outpatients that are in a post-stroke state. The primary
The replaceable cassette is integrally formed with a small primary container for fast response time when aspirating, and an integrally formed, larger secondary container into which the contents of the primary container are periodically flushed. During aspiration, the secondary container is sealed from the primary container and, therefore, has no adverse effect on aspiration response time. The primary container is located above the secondary container and the two containers are connected by a standpipe through which substances are flushed by the force of gravity in emptying the contents of the primary container into the secondary container. Although the cassette will operate with microsurgical consoles having two separate vacuum sources, only one vacuum source is required.
Moms of kids with swallowing dysfunction - Group for moms of children having swallowing dysfunctions, such as aspiration, laryngeal penetration,...
Unique coherent compendium of the theoretical underpinnings of thin film dynamics, in particular their instabilities Presents a large range of
Breathing-Swallowing Discoordination and Inefficiency of an Airway Protective Mechanism Puts Patients at Risk of COPD Exacerbation
Anyway I was recently admitted to the KKH. It was a controlled admission, or rather voluntary on mum and dads part. The reason was that we have been advised by the feeding therapist to get a nasal feeding tube put into me. I was kind of struggling through oral feeding of liquid, plus there is the danger of silent aspiration as a VFSS had shown previously. So the nasal feeding tube would bypass the throat and down into the stomach. This is to help me receive my adequate amount of milk or water each day, and reduce the chances of liquid going into my lungs ...
Chronic aspiration pneumonia is a form of aspiration pneumonia according time of onset. This can include changes caused by microaspiration or macroaspiration of oro-gastric content through time. Pathology This results from repeated passage of f...
TY - JOUR. T1 - Predictors of radiolucent foreign body aspiration. AU - Mortellaro, Vincent E.. AU - Iqbal, Corey. AU - Fu, Roxanna. AU - Curtis, Heather. AU - Fike, Frankie B.. AU - St. Peter, Shawn D.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Background Children frequently present for suspected foreign body aspiration, many have mild symptoms and/or negative radiographs raising the question of a radiolucent foreign body aspiration. Method Retrospective review of patients having bronchoscopy for suspected radiolucent foreign body aspiration from 2000 to 2010 collecting demographics, history, hospital presentation, radiographic, and operative details. Pearsons correlation was used between event history, presentation, radiographic details and bronchoscopically identified foreign body with P value , 0.01. Results 138 patients, mean age 2.6 years, mean weight 15.6 kg, 68% male. Event symptoms: 81% witnessed events, 64% wheezing, 43% coughing, 39% choking, 6% stridor, and 0.7% lethargy. Hospital ...
Laryngotracheal separation is a surgery performed to treat patients with chronic aspiration. In chronic aspiration food or saliva contents go between the vocal folds into the trachea or windpipe, leading to multiple lung infections or pneumonias.In a laryngotracheal separation the trachea is divided into two portions. The superior, or upper portion nearest the vocal folds is surgically closed off. The inferior, or bottom portion of the trachea closest to the lungs is attached to the skin
TY - JOUR. T1 - Laryngeal adductor reflex and pharyngeal squeeze as predictors of laryngeal penetration and aspiration. AU - Aviv, Jonathan E.. AU - Spitzer, Jaclyn. AU - Cohen, Manderly. AU - Ma, Guoguang. AU - Belafsky, Peter. AU - Belafsky, Peter C. PY - 2002. Y1 - 2002. N2 - Objectives: The contribution of laryngopharyngeal (LP) sensory deficits to the outcome of swallowing and the relationship between sensory and motor deficits in the laryngopharynx is unclear. The study purpose is to determine if patients with LP sensory and motor deficits are at increased risk for laryngeal penetration and aspiration during swallowing, and to determine the relationship between pharyngeal motor weakness and LP sensory deficits. Materials and Methods: Endoscopic evaluation of swallowing with sensory testing was performed on 122 dysphagic patients who were prospectively divided into two groups. The control group was 76 patients with normal sensitivity, determined by an intact laryngeal adductor reflex (LAR) ...
Effect of Removal of Follicles through Repeated Transvaginal Follicle Aspiration on Subsequent Follicular Populations in Murrah Buffalo (Bubalus bubalis - Buffalo;Follicles;Ovum Pick-up;TVOR;
Foreign body aspiration - a foreign body aspirated into the bronchial airways can result in signs and symptoms that can mimic asthma. Try algorithm.
CPT® 92616 in section: Flexible fiberoptic endoscopic evaluation of swallowing and laryngeal sensory testing by cine or video recording
TY - JOUR. T1 - Assessment of the prevalence of microaspiration by gastric pepsin in the airway of ventilated children.. AU - Gopalareddy, Vani. AU - He, Zhaoping. AU - Soundar, Sam. AU - Bolling, Laura. AU - Shah, Mansi. AU - Penfil, Scott. AU - McCloskey, John. AU - Mehta, Devendra I.. PY - 2008/1. Y1 - 2008/1. N2 - AIM: Mechanically ventilated patients are at risk for aspiration of gastric contents. The aim of this observational study was to determine the prevalence of micro-aspiration in children with cuffed and uncuffed endotracheal (ET) tubes and with tracheostomies and to assess the effect of feeding status on aspiration. Micro-aspiration was determined by measuring gastric pepsin in tracheal aspirates. METHODS: We studied 27 children on ventilators in paediatric intensive care unit (PICU) and 10 children undergoing elective surgeries for various indications. Tracheal aspirates were collected from children on ventilatory support in the intensive care unit during medically indicated ...
Kikuchi-Fujimoto disease on aspiration cytology: diagnostic dilemma and clinicopathologial correlation - A retrospective study in a tertiary care hospital-ACHR-Print ISSN No:-2581-5725 Online ISSN No:-2456-9267Article DOI No:-10.18231/j.achr.2019.044,IP Archives of Cytology and Histopathology Research-IP Innovative P
This study by Vallés and colleagues is one of the few randomized controlled trials suggesting the effectiveness of a preventive measure for ventilator-associated pneumonia, and the second trial dealing with subglottic secretions drainage (1, 2). This trial shows that continuous aspiration may reduce the incidence of ventilator-associated pneumonia by almost half or delay its onset. Although investigators were not blinded to treatment allocation and an intention-to-treat analysis was not done, one strength of this study is that the diagnosis of pneumonia was ascertained using specific sampling techniques. Similar to the results of many studies of "selective digestive tract decontamination," however, none of the major outcome measures of prophylaxis was affected by the maneuver. These results contradict those from epidemiologic studies that showed increased mortality or length of stay in patients with nosocomial pneumonia. This lack of effect of continuous aspiration on outcome may be related to ...
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Results 1553 patients between the ages of 17 and 93 years (median age 55 years) had 18FDG PET CT performed during this period. Increased focal FDG uptake in the colon was detected in 179 of 1553 patients studied (11.5%). Endoscopic evaluation was performed in 71 (39.7%) of these patients, flexible sigmoidoscopy in 25 (35.2%) and colonoscopy in 46 (64.8%). Non-malignant pathology was found in 45 of 179 patients (25.1%); 17 (9.5%) were tubulovillous adenomas; 6 (3.4%) had villous adenomas; 9 (5.0%) were tubular adenomas; 4 (2.2%) hyperplastic polyps; 11 (6.1%) were normal colonic tissue and 1 (0.6%) was active inflammatory bowel disease. From the patients with increased 18FDG uptake in the colon, 19 (10.6%) were subsequently found to have adenocarcinoma on histology. This represents 26.8% of the 71 patients who received endoscopic evaluation. ...
Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating anatomical risk structures related to the development of radiation-induced dysphagia, as well as methodological aspects in the evaluation of swallowing. Another objective was to translate and validate the quality of care instrument Swallowing Quality of Care questionnaire (SWAL-CARE) in a mixed Swedish dysphagia population. Methods: The studies were conducted at the Sahlgenska University Hospital and included patients from the otorhinolaryngology clinic. In study I-III, patients who had received curative (chemo)RT for HNC underwent a videofluoroscopic examination of swallowing function (VFS) 6-36 months post-RT. Dysphagia severity was measured according to the Penetration-Aspiration Scale (PAS). All patients answered questions regarding difficulties when drinking, eating, ...
Aspiration or ingestion of foreign objects including instruments, materials or even tooth is a relatively uncommon risk during dental procedures [14]. Yet, it is reported to be the second most common reason for foreign body aspiration in the lung [13]. Actually, the accidents could happen during various dental procedures due to some factors and associated with certain incidence, suggesting the importance of patients safety and instituting precautions and countermeasures at all times.. However, most literature only reported one or several cases with limited information on the description of the accidents. There were hardly any review on making comprehensive record and discussion of accidental cases.. Therefore, thorough documentation of the accident is stressed in this study so as to arouse the dental personnels attention, and further to facilitate analysis of the literature, and summarize the prevention and treatment measures on accidental aspiration and ingestion.. In this article, a total of ...
INGESTION: Do not ingest. Ingestion of small quantities is usually nonfatal unless aspiration occurs. Aspiration may lead to chemical pneumonitis which is characterized by pulmonary edema and hemorrhage and may be fatal. Signs of lung involvement include increased respiratory rate, increased heart rate, and a bluish discoloration of the skin. Coughing, choking, and gagging are often noted at the time of aspiration. Gastrointestinal discomfort may develop, followed by vomiting with a further risk of aspiration. Ingestion may cause gastrointestinal distress. Severe oral intoxication will lead to intense burning of the throat and may result in drowsiness, dullness, numbness, and headache followed by dizziness, weakness, and nausea. Loss of consciousness ...
We discuss the manufacture and use of a prism pair to measure the refractive index of thin liquid films with a spectrometer. The method requires only a drop of liquid and is accurate to ∼2 × 10-4.. © 2001 Optical Society of America. Full Article , PDF Article ...
This article investigates the evaporation, profile, and position of a thin liquid film and meniscus formed in microscale spaces with periodic nanorelief on the ...
PATH sought ideas from experts, innovators, and technology developers worldwide, crowdsourcing solutions with great promise to accelerate progress toward reaching the 2030 health targets.. People in nearly 50 countries nominated more than 500 innovations for consideration. Dozens of independent health experts then assessed and ranked them, selecting the 30 innovations featured in the report.. "Innovation is the essential ingredient in empowering communities with solutions they can use to transform their own health," said Steve Davis, PATH President and CEO. "To achieve the 2030 health targets, we must focus our brightest minds, collective resources, and shared aspirations on accelerating innovations with the most potential for impact.". "World leaders are coming together in 2015 around new global goals that can ensure good health and equal opportunity for all. By prioritizing and coordinating investments in innovations that can deliver the greatest health value for money, we can create ...
The mass on his tail was classic signs to a tick bite, and we had just pulled ticks off him from a walk in the woods--so I thought we just missed one. Vet agreed thats what it looked like to her, too. Antibiotics didnt work, and thats when we decided to take the mass off just to be sure. When all was said and done the entire procedure, antibiotics, etc was about $300. That includes the steroid injections, biopsy, fine needle aspiration on the tick bite, surgery, anesthetic, etc. It also includes his staples as he had stitches but with it being in such a bad spot he accidentally busted the stitches out, and needed another round of antibiotics , staples, and pain meds ...
In our interview earlier this year with Mark Allen PhD, Director of Marketing and Genomics for Trans Ova (Read more - Fast Track Genetics: More Results in Less Time), a company that has performed ovum pickup aspirations on 8,668 in the first 8 months of this year alone, we asked Mark if these changes were good or bad for the industry. The following was his response:. "It is human nature, when presented with the latest greatest technology to look for the downside. You ask yourself, "What is the worst case scenario?" Some breeders may be concerned that the market is being flooded, leaving no room for the middle market cattle. To that comment, Dr. Allan gives this well-considered response, "Many technology improvements have led to dramatic increases in genetic improvement. One of the early changes that led to a giant leap in genetic gain was implementation of artificial insemination (AI) in the dairy industry. This technology is widely accepted today and used by producers large and small. ...
This trial will evaluate the efficacy and tolerability of infliximab in patients with moderate-to-severe ulcerative colitis. The primary endpoints are clinical
A balloon occlusion device for aspirating embolic material from a blood vessel, such as from the aorta during cardiac surgery. The device includes an arterial cannula having a proximal end adapted to receive blood from a bypass-oxygenator machine, a distal end adapted to enter an artery, and a blood flow lumen extending between the proximal end and an outlet on the distal end. The cannula has an aspiration port proximate to the outlet, which communicates with an aspiration lumen. The cannula also includes an inflatable balloon attached to the cannula between the outlet and the aspiration port and capable of assuming an inflated condition for occluding a blood vessel. To use the device, the distal end of the cannula is introduced into a blood vessel, such as the aorta, the outlet is oriented downstream for delivering blood, and the balloon is inflated to occlude the vessel. Fluid may then be flushed into and aspirated out through the aspiration port as desired to remove loose embolic material from the
Baseline characteristics were similar between the trophic-feeding (n = 508) and full-feeding (n = 492) groups. The full-feeding group received more enteral calories for the first 6 days, about 1300 kcal/d compared with 400 kcal/d (P , .001). Initial trophic feeding did not increase the number of ventilator-free days (14.9 [95% CI, 13.9 to 15.8] vs 15.0 [95% CI, 14.1 to 15.9]; difference, -0.1 [95% CI, -1.4 to 1.2]; P = .89) or reduce 60-day mortality (23.2% [95% CI, 19.6% to 26.9%] vs 22.2% [95% CI, 18.5% to 25.8%]; difference, 1.0% [95% CI, -4.1% to 6.3%]; P = .77) compared with full feeding. There were no differences in infectious complications between the groups. Despite receiving more prokinetic agents, the full-feeding group experienced more vomiting (2.2% vs 1.7% of patient feeding days; P = .05), elevated gastric residual volumes (4.9% vs 2.2% of feeding days; P , .001), and constipation (3.1% vs 2.1% of feeding days; P = .003). Mean plasma glucose values and average hourly insulin ...
Khatony, A. and Abdi, A. and Karimi, B. and Aghaei, A. and Brojeni, H. S. (2019) The effects of position on gastric residual volume of premature infants in NICU. Italian Journal of Pediatrics, 45 (1). ...
The incidence of pulmonary aspiration is low in children undergoing elective surgery, even when allowed free clear fluids until called to the operating suite.
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In a retrospective review of 155 children with tracheobronchial foreign body aspiration (FBA), there were ten patients who had pneumomediastinum (PM) on an initial chest radiograph. Nine of ten...
Laryngectomy is a surgery in which the larynx or voice box is removed. A laryngecotmy is performed most often for laryngeal cancer, but may be performed for individuals who suffer from chronic aspiration. A cut is made on the skin and larynx is removed, the throat is opened and recreated, and the trachea is attached to the skin to create a permanent stoma.
The examination was carried out with an Olympus ENF-P4 laryngoscope attached to a camera and a color monitor. All examinations were videotaped. A neurologist experienced in using FEES and a speech-language pathologist (S.O.) jointly completed all FEES procedure. The standard FEES protocol was followed [23, 24] with slight modifications as was described previously [25]. In brief, patients were evaluated at bedside on the local stroke unit in an upright position. The laryngoscope was passed through the most patent naris without administration of a topical anesthetic or vasoconstrictor to the nasal mucosa. The base of the tongue, pharynx and larynx were viewed. Before the presentation of any bolus, the patients secretion level was noted and classified as "no pooling of secretions", "pooling without penetration/aspiration" and "pooling with penetration/aspiration". For evaluation of swallowing, the endoscope was placed in the high position above the epiglottis before and during the swallow to ...
Background Foreign body aspiration can result in a spectrum of presentations, from minimal symptoms, often unobserved, to respiratory compromise, failure, and even death. This article is not intended to distinguish in detail acute airway obstruction from foreign body aspiration; for these patients, emergency life-saving interventions are nee...
The Journal of Thoracic Disease (JTD, pISSN: 2072-1439; eISSN: 2077-6624) publishes manuscripts that describe new findings in the field provide current, practical information on the diagnosis and treatment of conditions related to thoracic disease (lung disease, cardiology and esophagus disease).
Aspiration is a common finding in the postesophagectomy barium swallow that often necessitates premature termination of the study prior to complete evaluation of the gastric conduit. More importantly, aspiration may play a significant role in the high incidence of postoperative pulmonary complications in this population. The chin tuck maneuver is a postural technique that reduces and often eliminates aspiration in swallowing-impaired patients. To evaluate the ability of the chin tuck maneuver to prevent aspiration during radiographic examination of the gastric conduit, the technique was used in 21 esophagectomy patients who aspirated during a swallowing evaluation combining the barium swallow and videofluoroscopy. Aspiration was eliminated in 81% of aspirators using the chin tuck maneuver. The results of this study demonstrate that the chin tuck maneuver is a simple technique that should be attempted in patients who aspirate postesophagectomy during radiographic imaging studies that require multiple