A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. Subsequently, amine levels recovered slowly, but remained depressed 6 months after reserpine injection. Following reserpine treatment, glyoxylic acid-induced fluorescence or neutral red staining closely mirrored the HPLC-determined time course of amine depletion and recovery. Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. The threshold concentration of reserpine necessary to produce amine depletion was approximately 1 microM. We found that reserpine treatment eliminated biting behavior within 4 d following injection. Biting behavior ...

The treatment of hypertension with reserpine is described. When used alone it produced adequatefalls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its parasympathetic side effects. The combination of reserpine and pentapyrrolidinium is regarded as the best therapeutic regime for severe hypertension. Some mild cases of hypertension may be managed with reserpine alone.. ...

Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocker reserpine was previously shown to increase enkephalin levels several-fold. To explore the biochemical mechanism of this effect, we examined the effect of reserpine treatment on the activities of three different peptide precursor processing enzymes: carboxypeptidase E (CPE) and the prohormone convertases (PCs) PC1/3 and PC2. Reserpine treatment increased both CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered for any enzyme. Further analysis showed that the increase in CPE activity was due to an elevated Vmax, with no change in the Km for substrate hydrolysis or the levels of CPE mRNA. Reserpine activation of endogenous processing enzymes was also observed in extracts prepared from PC12 cells stably expressing PC1/3 or PC2. In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3 and PC2, with dopamine quinone the most ...

Serotonin is known as one of the most important neurotransmitters. This amine structured neurotransmitter Ievel is influenced in migraine. Plasma serotonin Ievel is essentially decreased during migraine atacks. It is known that reserpine has an amine-releasing effect. In this study, migraine-Iike episodes were constituted in thirty-three guinea pigs by intraperitoneal reserpine administration. Then the auditory brainstem evoked potentials were recorded. All absolute and interpeak lalency values were initially increased at the second hour of reserpine administration and reached to the maximum values at third hour, and then gradually decreased up to twelfth hour. This result mainly reflects the brainstem involvement in migraine-Iike attack induced by reserpine administration. Subsequent Iatency parameters which are close to baseline values may be attributed to the fact that these changes are temporary and follow the variations in the serotonin Ievels. . ...

It has been suggested that reserpine blocks expression of delayed hypersensitivity (DH) by depleting tissue mast cells of serotonin (5-HT), thereby preventing a T cell-dependent release of mast cell 5-HT necessary to localize and to amplify the DH response. However, reserpine blocks expression of DH in mast cell-deficient mice. We therefore decided to reevaluate the mechanism by which reserpine abrogates expression of cellular immunity, and investigated whether the drug might interfere with T cell activity in vitro or in vivo. At concentrations as low as 4 microM, reserpine profoundly suppressed baseline or antigen-augmented levels of [3H]thymidine incorporation by immune lymph node cells obtained from mice sensitized to the contactant oxazolone [I-LNC(Ox)]. This effect was observed both with I-LNC derived from normal mice and with I-LNC derived from congenitally mast cell-deficient W/Wv mice, cell preparations that lacked detectable mast cells, histamine, and 5-HT. Furthermore, treatment of ...

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1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm2, mean ± SEM). Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5-15 mg/kg) did not influence these effects of reserpine, but vagotomy protected the rats against them. The α-adrenoceptor-blocking drugs phenoxybenzamine and phentolamine at 5 mg/kg were protective against injury. However, a 10 mg/kg dose of either blocker was more effective (2.2 ± 0.5 mm2 and 3 ± 0.8 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM, P ,0.01) and a dose of 15 mg/kg afforded complete protection.. 2. Methysergide, a 5-hydroxytryptamine receptor antagonist, produced a dose-dependent increase in the reserpine-induced injury; a significant (P ,0.05) increase was noted with 15 and 20 mg/kg (47.5 ± 2.9 mm2 and 49.4 ± 2.2 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM).. 3. The results suggest that, in the rat, reserpine causes vagal ...

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance. Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered ...

The first demonstration of an animal model for PD was reported by Carlsson in the 1950s using rabbits treated with reserpine. Reserpine is a catecholamine-depleting agent that blocks vesicular storage of monoamines. The akinetic state, resulting from reserpine-induced dopamine depletion in the caudate nucleus and putamen, led Carlsson to speculate that PD was due to loss of dopamine neurotransmission. This speculation was supported by the discovery of reduced striatal dopamine in postmortem brain tissue of PD patients and led to the subsequent use of levodopa (in conjunction with a peripheral dopa-decarboxylase inhibitor) for symptomatic treatment of PD (2,3). Thus, the initial observations derived from an animal model led to an important clinical therapy that still remains the gold standard.. Was this article helpful?. ...

Reserpine lowers blood pressure by slowing down your nervous system. This allows your blood vessels to relax and dilate (widen), which helps your heart beat more slowly and improves blood flow. Reserpine is used to treat hypertension (high blood pressure). Reserpine is also used to treat agitated psychotic conditions...

18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of 18F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced 18F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. After

Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...

Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...

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This study describes the effects of brain-stem cholinergic laterodorsal tegmental (LDT) stimulation on the synaptic responsiveness of anterior thalamic (AT) neurons. A sample of AT cells, physiologically identified by their short-latency (less than 6.5 msec) response to mammillary body (MB) stimulation, was recorded in unanesthetized, chronically implanted cats and in urethane-anesthetized cats. In chronic experiments, LDT stimulation evoked a short-latency (10-20 msec) excitation in most AT cells. Moreover, brief LDT trains (3 shocks at 300 Hz, every 3 sec) enhanced the responsiveness of AT cells to both MB (orthodromic) and cortical (ortho- and antidromic) stimuli. This effect did not vary as a function of the interval between LDT conditioning and MB or cortical testing shocks, but as a function of the number of trials. The effects of LDT stimuli resisted reserpine treatment (0.75 mg/kg), suggesting that they were not dependent on the coactivation of monoaminergic fibers. Finally, LDT trains ...

A series of phenolic hydroxy-2-aminotetralins with either a primary or a tertiary (N,N-di-n-propylated) amino group was investigated on electrically evoked acetylcholine release from striatal slices of reserpinized rats, a dopamine (DA) D2 receptor model. 7-Hydroxy-2-aminotetralin (7-OH-AT) was found to be the most active inhibitor among the primary amines, whereas 5-hydroxy-2-(N,N-dipropylamino)tetralin (5-OH-DPAT) was the most potent compound among the tertiary amines; in the 7-OH series, the activity resided in the (2R)-enantiomers, in contrast to the 5-OH series, where the (2S)-enantiomers represented the effective form. A similar structure-activity pattern was earlier found for the same series of DA agonists at the striatal DA D1 receptor. Differences between the effects of the compounds at the two DA receptor subtypes concerned the N,N-dipropyl substitution which influenced the D2 activity much more pronouncedly, and an added 6-OH group (i.e., a catechol function), which seemed to be of ...

Atıf İçin Kopyala Işbil B., Güleç G. , Ozlük K. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.17, ss.1-6, 2006 (SCI Expanded İndekslerine Giren Dergi) ...

TY - JOUR. T1 - Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats. AU - Manara, L.. AU - Garattini, S.. PY - 1967/11. Y1 - 1967/11. N2 - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. AB - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. KW - Tritium ...

The adrenal glands increase and the thymus and secondary reproductive organs decrease in weight when mice are placed in groups. These changes in weight are related to the size of the population or group and presumably are a reaction to sociopsychological pressures. If such a presumption is correct, reserpine should diminish the differences in the organ weights of grouped and of isolated mice. Grouped and isolated male mice were given 40-50 µg of reserpine (Serpasil, Ciba) per day in their drinking water and the results compared with those from similar numbers of grouped and isolated mice without reserpine. The average number of fights per 10-minute interval per day was 51.4% less in the treated than in the untreated mice for the first 3 days after grouping. Grouped mice, treated and untreated, had heavier adrenals and lighter thymus glands and secondary reproductive organs than their isolated controls. Treatment of grouped mice with reserpine was accompanied by a 5% lower adrenal weight, 28% ...

TY - JOUR. T1 - Reserpine and breast cancer. T2 - A longitudinal study of over 2000 hypertensive women. AU - Labarthe, D. R.. AU - OFallon, W. M.. PY - 1977/1/1. Y1 - 1977/1/1. UR - http://www.scopus.com/inward/record.url?scp=0017672195&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017672195&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017672195. VL - 106. JO - American Journal of Epidemiology. JF - American Journal of Epidemiology. SN - 0002-9262. IS - 3. ER - ...

50-55-5|Reserpine|Sigma Aldrich|unipres|methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-dia...

C02AA02 - Reserpine. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs classified in groups at five different levels.

Rabbits made tolerant to narcotic and lethal doses of l-norepinephrine (3.2 mg/kg intravenous) were infused with dl-norepinephrine-H3 at a rate of 50 µc/kg min-1 for 20 minutes. Concentrations of norepinephrine-H3 in plasma obtained during infusion and for 40 minutes thereafter were similar for the tolerant group, controls and a group treated 24 hours earlier with reserpine (1 mg/kg). Except for reduced concentrations in the heart, uptake of norepinephrine-H3 in organs of tolerant animals was found similar to the controls. In the groups treated with reserpine, norepinephrine-H3 binding was less in all organs but the kidney.. Only about half the normal catechol concentrations were found in hearts of tolerant animals, yet both spleen and kidney were found to contain several times the control amount. Although reserpine markedly diminished the catechol content of the heart, no significant decrease occurred in spleen or kidney.. Mean concentrations of unchanged norepinephrine-H3 in the urines of ...

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...

This MassBank Record with Accession PB005762 contains the MS2 mass spectrum of Reserpine with the InChIKey QEVHRUUCFGRFIF-MDEJGZGSSA-N.

Wodibo - Bilateral color changes in the hands after cold exposure or emotional stimuli in patients with underlying connective positive results to intra-arterial reserpine.

ELOFF, I and ESTERHUYSEN, W. Reserpine for the treatment of refractory mania. S. Afr. j. psyc. [online]. 2014, vol.20, n.1, pp.31-32. ISSN 2078-6786.. ...

As this eMedTV page explains, your healthcare provider needs to be aware of all your other medications before you start Allegra-D. This page gives an explanation of why this is the case and explains what can happen when Allegra-D is taken with reserpine.

Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...

TY - JOUR. T1 - Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia. AU - Palfai, Tibor. AU - Walsh, Thomas J.. AU - Albala, Bruce J.. AU - Brown, Oliver M.. PY - 1977/1. Y1 - 1977/1. N2 - In a series of experiments the effects of reserpine, l-Dopa, and d,l,5-hydroxytryptophan (d,l,5-HTP) on retention of a passive avoidance training in mice were investigated. Reserpine (2.5 mg/kg) produced amnesia when given at 120 min before but not at 30 min before or at 0, 10, 30, or 90 min following training. This time-dependent reserpine effect did not appear to be due to either an alteration in footshock sensitivity during training or to the drug producing state-dependent learning. The amnesic effect of reserpine could be blocked when both l-Dopa and d,l,5-HTP were also administered up to 10 min but not at 30 or 90 min following training. The drugs, l-Dopa or d,l,5-HTP, given alone or in higher doses, could not at any time counteract the ...

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Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary somatosensory cortex following sciatic nerve section. Article date: 1991/1/1 PubMed ID: 1808975 Journal name: Somatosensory & motor research (ISSN: 0899-0220)

hypertension and sexual function in men and outlines a management strategy for clinicians that attempts. drugs such as guanethidine and reserpine.16 Due to.. Coronary Artery Disease and ED Epidemiological studies show that nearly 75% of men with coronary artery disease also have ED.Vascular and cavernosal smooth muscle dysfunction appear to share the same risk factors, and ED may be an early signal of impending cardiovascular problems. (Heart 2003;89 251-3 J Urol 2003; 170S46-50). The risk factors for coronary heart disease and ED are.. Superdrug is expanding its erectile dysfunction portfolio after demand for services increased by 13% between May and June, it has announced.. 12 medications found for severe psychosis Sorted by User Reviews Drug Name Indication Type User Reviews reserpine 0.25 mg tablet On Label RX 6 reviews serpasil tablet On Label RX 1 Reviews.. Reserpine (Serpasil) Spironolactone (aldactone) triamterene (maxzide) Verapamil (Calan) Thiazides are the most common cause of ...

Amphetamine released 3-H-norepinephrine from rat cerebral cortex tissue which had previously accumulated the 3-H-amine. Destruction of noradrenergic nerve endings by pretreatment of the rats with 6-hydroxydopamine inhibited the accumulation of 3-H-norepinephrine by the tissue and reduced the proportion of the 3-H-amine which was released by amphetamine. Inhibition of storage of 3-H-norepinephrine within nerve endings by pretreatment of the animals with reserpine also reduced accumulation of 3-H-norepinephrine but did not reduce the proportion of the accumulated 3-H-amine which was released by amphetamine. The addition of desipramine (an inhibitor of neuronal uptake) further reduced the accumulation of 3-H-norepinephrine in animals pretreated with reserpine but had no further effect in animals pretreated with 6-hydroxydopamine. A greater proportion of the 3-H-norepinephrine was converted to 3-H-deaminated metabolites in tissues of reserpine-treated animals than in the tissues of control or ...

Orally administered reserpine is readily absorbed from the GI tract. During this process at least a portion of the drug is metabolized by the intestinal mucosa and then presumably is acted upon by serum esterases. Methylreserpate and trimethoxybenzoic acid are the primary metabolites which result from the hydrolytic cleavage of reserpine. Since most of the blood leaving the GI tract passes through the liver via the portal vein, hepatic metabolism would also be expected to reduce reserpine levels in the blood. The relative contributions of serum esterases versus hepatic metabolism in the biotransformation of reserpine in vivo are not known. However, very little unmetabolized reserpine is eventually eliminated in the urine. In the liver, it is quite likely that both microsomal oxidative and hydrolytic enzymes contribute to the metabolism of reserpine. It seems that microsomal oxidation (such as the demethylation of the 4-methoxy group on the TMBA moiety) must precede hydrolysis since inhibition of ...

Description of the drug chlorothiazide and reserpine. - patient information, description, dosage and directions. What is chlorothiazide and reserpine!

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The effects of length of caging and reserpine administration on the in vivo recording of uptake and retention of idoine-131 by the thyroid glands of House Sparrows (Passer domesticus) were investigated. The uptake of iodine-131 was lower in birds caged for shorter periods (2 and 10 days) as compared to those caged for longer periods (90 and 100 days) prior to testing. The release of radioiodine from the thyroid area as measured by logarithmically plotted release slopes seems depressed in birds held only 2 days prior to testing. Release in birds held for 10 days did not differ appreciably from that in birds held 90 days prior to testing. Uptake and retention of iodine-131 did not differ significantly between birds given reserpine and those given a placebo, either in a group of birds tested 2 days or one tested 90 days after capture ...

TY - JOUR. T1 - Brain Biogenic Amine Depletion and Mood. AU - Mendels, Joseph. AU - Frazer, Alan. PY - 1974/4. Y1 - 1974/4. N2 - To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. The behavioral changes associated with reserpine administration were interpreted as being primarily a psychomotor retardation-sedation syndrome, due perhaps to a dopamine deficiency, and would not be an adequate model for clinical depression. In susceptible persons, particularly those with a prior history of depression, this psychomotor retardation-sedation might be sufficient to trigger a depression-like episode. More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that ...

The present study aims to evaluate the antidepressant efficacy of curcumin nanoparticles on rat model of depression induced by reserpine. Rats were divided into control, the rat model of depression induced by daily i.p. injection of reserpine (0.2 mg/kg for 21 days), and the rat model of depression treated daily with the formulated CNPs (20 mg/kg for 7 and 15 days). The behavioral evaluation was a ...

When investigating potential drug-drug interactions in vitro or in vivo, selective inhibitors are needed that will affect the system investigated without unwanted effects on other components involved in the disposition of the drug. Many P450 inhibitors show substrate dependent effects and IC50 values should be interpreted with caution (Stresser et al., 2000). Quinidine and ketoconazole IC50 values listed in Table 2 are similar to data reported in the literature (Khojasteh et al., 2011). However, absolute P450 IC50 values could vary depending on the substrates and experimental systems used.. Most of the tested P-gp inhibitors showed potent or moderate CYP3A4 as well as moderate CYP2C19 inhibition. However, for three compounds (elacridar, reserpine, and verapamil) the inhibition of P-gp was much more potent than the CYP3A4 inhibition. These should be possible to use experimentally for efficient P-gp inhibition without affecting CYP3A4 at concentrations in the low μM range. Reserpine is a potent ...

Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Then Amitriptyline (5, 10, 20 mg/kg, i.p.) was administered to separate groups of male Wistar rats. All treatments were carried out two hours after colitis induction and continued daily for four days. Dexamethasone (1 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. At day five, animals were euthanized and colonic tissue injuries were assessed macroscopically and pathologically. Myeloperoxidase activity as a marker of neutrophil infiltration was also measured in colonic tissues. Results showed that reserpine (6 mg/kg, i.p.) intensified colitic condition. Compared to control

Physician reviewed hydralazine/hydrochlorothiazide/reserpine patient information - includes hydralazine/hydrochlorothiazide/reserpine description, dosage and directions.

Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.

Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733)

Several efflux proteins are well described in gram-positive bacteria, including Bmr in Bacillus subtilis (1) and NorA in Staphylococcus aureus (15). These can mediate low-level resistance to hydrophilic fluoroquinolones and a variety of unrelated compounds; both are inhibited by reserpine (14, 15). More recently, reserpine was shown to inhibit the level of accumulation of ethidium bromide in an ethidium bromide-selected mutant of S. pneumoniae which showed cross-resistance to fluoroquinolones (5). For this reason we used reserpine to detect mutants resistant to fluoroquinolones by an efflux mechanism.. We showed that reserpine significantly increased the activity of norfloxacin against several norfloxacin-selected mutants. These presumptive efflux mutants also showed increased levels of resistance to ethidium bromide and acriflavine, which agrees with the description by Zeller et al. (20) of the presence of an efflux pump in pneumococci. Ethidium bromide accumulation in strain 1N27, a ...

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Comprehensive alcohol & food interactions for hydralazine / hydrochlorothiazide / reserpine. Includes High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

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Concluding comments.We validated a new method for assessing the reserpine-mediated effect on fluoroquinolone efflux that is not dependent upon fluorescence. Such a simplified assay for estimating NorA-type efflux is needed because this resistance mechanism is becoming increasingly important, and an agar screening test may not be reliable since reserpine is poorly soluble and present in agar as a suspension, not a solution.. We found the degree of growth inhibition mediated by reserpine was lessened in the new bulkier and/or more hydrophobic agents moxifloxacin (solubility, 2.4 g/100 ml), sparfloxacin (solubility, 0.11 g/100 ml), and trovafloxacin (solubility, 0.002 g/100 ml). However, the growth of organisms in the smaller, more hydrophilic drugs ciprofloxacin (solubility, 3.5 g/100 ml) and levofloxacin (solubility, 2.5 g/100 ml) was strongly inhibited by the presence of reserpine. Of the fluoroquinolones tested, ciprofloxacin has the least bulky C-7 substituent, a piperasine moiety, with ...

Hao is still a relatively common tree in the remnant dry forests of Hawaii making us believe the trees were even more common in ancient times. So, why then are there so few records of the Hawaiians using this tree - surely it was good for something? Hao wood has been found in heiau suggesting it had some unknown religious purpose. But, other than this, reports about its use for construction and firewood are few and conflicting. Unfortunately, we cant go back in time to find the truth but there is one clue as to why Hawaiians may have shunned this native plant. Hao, like its relatives, contains an alkaloid called reserpine, used in other parts of the world to treat high blood pressure and some mental diseases (Degener & Degener 1957). Maybe, the first Hawaiians to use hao (remember, hao is endemic to Hawaii) used it for a very common need, firewood. As the wood burned, the smoke containing the reserpine was likely inhaled by the nearby Hawaiians. This uncontrolled dose of reserpine might have ...

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...

it means the extract reduced excitability and locomotor as well as exploratory behaviour. The extract thus has a strong sedative property. This is consistent with the fact that one of the main alkaloids found in the plant extract, reserpine, has been found to have some depressive effects on the nervous system. Reserpine causes depletion of the peripheral stores of catecholamines, which accounts for much of the beneficial antihypertensive effect employed over the years 14 . However, depletion of central stores of neurotransmitter amines is responsible for the antipsychotic effects and consequently its adverse side effects such as sedation, depression inability to perform complex tasks and Pseudo-Parkinsonism 15,16 .. The number of faecal boli was also significantly decreased in the test groups when compared to control. This however may not be very informative as there is still some controversy over whether the number of faecal boli and number of urine puddles can be used to accurately assess the ...

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Rausedyl-An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals.

48.. Gillespie JS, Mackenna BR: The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catecholamines and by DOPA. J Physiol 156:17, 1961. ...

Serpina should be taken inside after meal. The specific dose and duration of treatment are determined individually. In the early stages of hypertension you should be prescribed 0.05-0.1 mg 2-3 times a day. Further, if necessary (but subject to good tolerability), the dose is gradually increased. Maximum daily dose is 1 mg. If within 10-14 days, the hypotensive effect is not achieved, the medication should be overturned. After reaching the effect, the daily dose should be gradually reduced: first, up to 0.5 mg, then up to 0.2 mg and then to 0.1 mg. You should be prescribed the minimum effective dose for maintenance therapy. Treatment is held in courses of 2-3 month up to 4 times a year. In case of neuroses Reserpine is taken in a dose of from 0.25 mg 2-3 times a day to 0.5 mg 3-4 times a day. In case of mental illness on the first day you should be prescribed 0,25-2 mg, then, depending on the clinical situation, the daily dose may be increased to 10-15 mg. the maximum dose for adults: single - 2 ...

Paget and McNab were still disqualified from the 2013 Burghley and Pagets win was not reinstated because both horses had reserpine in their systems, but neither will be subjected to additional fines or suspensions.. On a New Zealand news site, Paget said:. I feel as though I had my career stripped from me and now someone has said hang on, you can have it back. It is complete relief, he said.. I didnt know if I would be cleared, despite knowing I had done nothing wrong. I knew it wouldnt be as easy as turning around and saying I didnt do it. I was fortunate that we were able to find the source of the contamination, trace it and prove it, and - most importantly - that I wasnt responsible nor could have known.. Click on the image below to watch the video interview.. ...

Lehnert, S, Toxicity to tumor cells of combined treatments with diethylamino- reserpine and radiation. Abstr. (1982). Subject Strain Bibliography 1982. 3894 ...

Is - Of the physiologic effects of the drug, the threshold to electroshock is lowered by reserpine but meprobamate has a blocking action on electroshock.

The Imodium complete caplets extra mechanical tensile strength fruit brand of loperamide should be taken with food treat or within 1 hour nap after his eating a meal. I die do nt think the vismodegib is increasing quite as made good as loperamide but it is sovereign not bad seamanship and supposedly safer. Loperamide will also potentiate reserpine in fact I once go

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