Exposure to renin angiotensin aldosterone system blockade (i.e. RAASB) may have a protective effect in patients with hospital-acquired acute kidney injury (AKI), according to new research presented at the National Kidney Foundations 2015 Spring Clinical Meetings.
Experimental data indicate the existence of a vascular tissue renin-angiotensin system in several different vessels from various animal models. Active renin can be locally synthesized into the vessel wall or taken up from circulating plasma to produce vascular angiotensin II. Using the human forearm technique, we produced evidence indicating the release of active and inactive renin and of angiotensin II from the vessels of hypertensive patients. Moreover, the production of vascular angiotensin II seems to be strictly correlated to the circulating renin profile, suggesting the possibility that vascular renin might be at least partially taken up from plasma. To investigate a possible function of the vascular renin-angiotensin system, we studied its interaction with sympathetic neurotransmission in essential hypertensive patients. In line with animal studies, vascular angiotensin II increases the vasoconstriction induced by the stimulation of the sympathetic nervous system through the potentiation ...
http://youtu.be/iAZmLkSCmY0 GIMA AMEZIA SARI G1F011016 DESKRIPSI Renin adalah enzim dengan protein kecil yang dilepaskan oleh ginjal bila tekanan arteri turun sangat rendah. Pengeluaran renin dapat disebabkan aktivasi saraf simpatis (pengaktifannya melalui β1-adrenoceptor) (Guyton dan Hall,1997). Angiotensin adalah hormone petida yang berasal dari protein angiotensinogen. Angiotensinogen di ubah menjadi angiotensin 1 dengan katalisis renin. Selanjutnya angiotensin…
Kidney damage is a common consequence of arterial hypertension, but is also a cause of atherogenesis. Dysfunction and/or harm of the endothelium in glomeruli and tubular interstitium damage the function of these structures and translates into dynamic changes of filtration fraction, with progressive reduction in glomerular filtration rate, expansion of extracellular fluid volume, abnormal ion balance, and hypoxia, ultimately leading to chronic kidney disease. Considering the key role played by endothelial dysfunction in chronic kidney disease, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension have critically reviewed available knowledge on the mechanisms underlying endothelial cell injury ...
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PARIS and NEW YORK, Jan. 15, 2020 -- Quantum Genomics (Euronext Growth - FR0011648971 - ALQGC, OTCQX - QNNTF), a biopharmaceutical company specializing in developing a new drug.
The purpose of this study is to see if individuals with HIV-infection, particularly those with increased belly fat, have abnormalities in the renin angiotensin aldosterone axis. Renin, angiotensin, and aldosterone are hormones that regulate salt and water balance in the body, and they may also have effects on sugar metabolism and cardiovascular health. There is some evidence that individuals with HIV-associated abdominal fat accumulation may have increased aldosterone, which may contribute to abnormalities in sugar metabolism and increased cardiovascular disease seen in HIV. The purpose of this study is the measure renin, angiotensin, and aldosterone activity, as well as other hormonal axes, in people with and without HIV infection, and with and without increased belly fat. The investigators hypothesize that aldosterone will be increased in HIV-infected individuals compared to those without HIV-infection, and that aldosterone will be further increased in HIV-infected individuals with increased ...
The purpose of this study is to see if individuals with HIV-infection, particularly those with increased belly fat, have abnormalities in the renin angiotensin aldosterone axis. Renin, angiotensin, and aldosterone are hormones that regulate salt and water balance in the body, and they may also have effects on sugar metabolism and cardiovascular health. There is some evidence that individuals with HIV-associated abdominal fat accumulation may have increased aldosterone, which may contribute to abnormalities in sugar metabolism and increased cardiovascular disease seen in HIV. The purpose of this study is the measure renin, angiotensin, and aldosterone activity, as well as other hormonal axes, in people with and without HIV infection, and with and without increased belly fat. The investigators hypothesize that aldosterone will be increased in HIV-infected individuals compared to those without HIV-infection, and that aldosterone will be further increased in HIV-infected individuals with increased ...
Progressive deterioration of renal function occurs during normal aging. Previous studies on the aging kidney have demonstrated glomerular hemodynamic changes, specifically, glomerular capillary hypertension, as maladaptations that lead to proteinuria and glomerular sclerosis over time. Aging rats treated with angiotensin-converting enzyme inhibition have relatively less proteinuria and sclerosis, suggesting that age-related changes in renal function may be associated with alterations in the intrarenal renin-angiotensin system, which thus may play a major role in the pathogenesis of these maladaptations. To investigate this possibility, renal and systemic renin-angiotensin systems were examined at an early phase of the aging process (3 months) and at a later phase (12 months) in male Sprague-Dawley rats. Although plasma renin and serum angiotensin-converting enzyme concentrations did not differ significantly, the intrarenal system showed down-regulation of renin mRNA and angiotensin-converting ...
Background: Renin-angiotensin system inhibition (RASI) is frequently avoided in aortic stenosis (AS) patients because of fear of hypotension. We evaluated if RASI with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) increased mortality in patients with mild to moderate AS. Methods: All patients (n = 1873) from the Simvastatin and Ezetimibe in Aortic Stenosis study: asymptomatic patients with AS and preserved left ventricular (LV) ejection fraction were included. Risks of sudden cardiac death (SCD), cardiovascular death and all-cause mortality according to RASI treatment were analyzed by multivariable time-varying Cox models and propensity score matched analyses. Results: 769 (41%) patients received RASI. During a median follow-up of 4.3 +/- 0.9 years, 678 patients were categorized as having severe AS, 545 underwent aortic valve replacement, 40 SCDs, 103 cardiovascular and 205 all-cause deaths occurred. RASI was not associated with SCD (HR: 1.19 [95% CI: ...
OBJECTIVE The term "receptor-associated prorenin system" (RAPS) refers to the pathogenic mechanisms whereby prorenin binding to its receptor dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling via the receptor. The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation.. RESEARCH DESIGN AND METHODS Long-Evans rats, C57BL/6 mice, and angiotensin II type 1 receptor (AT1-R)-deficient mice with streptozotocin-induced diabetes were treated with (pro)renin receptor blocker (PRRB). Retinal mRNA expression of prorenin and the (pro)renin receptor was examined by quantitative RT-PCR. Leukocyte adhesion to the retinal vasculature was evaluated with a concanavalin A lectin perfusion-labeling technique. Retinal protein levels of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule (ICAM)-1 were examined by ELISA. Retinal extracellular signal-regulated kinase (ERK) activation was ...
TY - JOUR. T1 - The effect of renin-angiotensin system blockade on visceral blood flow during and after thoracic aortic cross-clamping. AU - Joob, A. W.. AU - Harman, P. K.. AU - Kaiser, D. L.. AU - Kron, I. L.. PY - 1986. Y1 - 1986. N2 - Surgical procedures necessitating clamping of the thoracic aorta are associated with a high incidence of postoperative renal dysfunction. Plasma renin activity is elevated during and after thoracic aortic occlusion in animals. The pathophysiology of the renal dysfunction may involve the renin-angiotensin system. Blockade of the renin-angiotensin system was studied in a canine model during occlusion of the thoracic aorta. Saralasin, a competitive blocker of angiotensin II, and the converting enzyme inhibitor MK422 were studied. Sixteen animals were separated into three treatment groups: control (five animals), saralasin (five), and MK422 (six). All dogs underwent clamping of the thoracic aorta for 60 minutes. In control animals, plasma renin activity increased ...
Chronic RAS inhibition using ACE inhibitors or ARBs as monotherapy is the standard of care to treat the vasoconstrictive / pro-inflammatory effects of RAS activation. Despite a strong biological rationale, dual RAS blockade has been largely disappointing, with initial benefits seen on surrogate endpoints [55] not being translated to meaningful superior clinical benefit [80]. Data from outcome trials such as ONTARGET®, VA NEPHRON-D, ALTITUDE and ASTRONAUT have shown no renal or CV outcome benefits with dual RAS inhibition, and have even shown deleterious effects across most patient groups. For ACE inhibitor / ARB dual therapy, benefits appear confined to symptomatic HF in patients whose symptoms persist in the presence of maximized ACE inhibitor and beta-blocker treatment and not immediately post-MI, and arguably in severe hypertension while balancing the potential adverse effects [107].. The ONTARGET® trial was the first to allude to the need for caution over the use of dual RAS inhibition, ...
Aliskiren is an oral renin inhibitor, which inhibits the first rate limiting step in the renin angiotensin aldosterone system. In this study, sympathetic nerve sprouting and the inducibility of ventricular fibrillation after aliskiren treatment in my
Renin-angiotensin-aldosterone system inhibitors prevent the progression of kidney disease in patients with diabetic nephropathy, and we studied how that benefit varies by the type of diabetes and baseline urinary albumin. We pooled data from 49 randomized controlled trials in a meta-analysis using the ratio of endpoint urinary albumin levels in those treated compared to those untreated with renin-angiotensin-aldosterone system inhibitors in both fixed- and random-effects models. The urinary albumin excretion for treated microalbuminuric patients with Type 1 diabetes was on average 60% lower at the end of the trial compared with patients not treated with renin-angiotensin- aldosterone system inhibitors using the fixed-effects model and 67% lower using the random-effects model. There was no significant effect of treatment in patients with normal albumin excretion. For normoalbuminuric patients with Type 2 diabetes, urinary albumin excretion was on average 12% lower after treatment using the fixed-effects
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Locally expressed renin-angiotensin systems have been found in a number of tissues, including the kidneys, adrenal glands, the heart, vasculature and nervous system, and have a variety of functions, including local cardiovascular regulation, in association or independently of the systemic renin-angiotensin system, as well as non-cardiovascular functions.[7][9][10] Outside the kidneys, renin is predominantly picked up from the circulation but may be secreted locally in some tissues; its precursor prorenin is highly expressed in tissues and more than half of circulating prorenin is of extrarenal origin, but its physiological role besides serving as precursor to renin is still unclear.[11] Outside the liver, angiotensinogen is picked up from the circulation or expressed locally in some tissues; with renin they form angiotensin I, and locally expressed angiotensin-converting enzyme, chymase or other enzymes can transform it into angiotensin II.[11][12][13] This process can be intracellular or ...
Lupus nephritis (LN) is a significant cause of morbidity and mortality in patients with systemic lupus erythematosus. Delayed recognition and diagnosis of LN may be a common cause of chronic kidney disease among South Africans. Renal biopsy is the gold standard of diagnosing LN; however, this service is not available in many centres and the use of urinalysis, urine microscopic examination and other serological tests can be useful in identifying patients with proliferative LN. Proliferative types of LN (class III, class IV and mixed class V) comprise the larger proportion of patients with this condition. Patients receiving immuno suppressive therapy need to be monitored closely for side-effects and drug-related toxicities. LN patients with end-stage renal disease (class VI) need to be prepared for renal replacement therapy (dialysis and renal transplantation). In all patients, treatment should include adjunctive therapies such as renin angiotensin aldosterone system blockade, bone protection (with
The local renin-angiotensin system (RAS) is closely related to bone metabolism. However, it is unknown whether the local RAS is related to bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIOP). Here, we revealed that the two main characteristics of GIOP might inhibit bone formation and enhance bone resorption. INTRODUCTION: The aim of this study is to assess the expression of the main RAS components in the trabecular bone of lumbar vertebrae in GIOP and analyze the relationship between the major RAS components and BMD. METHODS: We collected 96 inpatient cases of lumbar disc herniation from patients who underwent dual-energy X-ray absorptiometry examinations followed by surgical treatment in our hospital. Patients were divided into the GIOP group (n = 48) and control group (n = 48). The circulating and local expression levels of the main RAS components were examined. The correlation between the main RAS components and BMD was then analyzed. RESULTS: The mRNA expression of local ...
Both insulin resistance and hyperinsulinemia5 and increased activation of the RAS14 have been associated with hypertension, accelerated atherosclerosis,4 and increased risk for cardiovascular events. However, the status of the RAS in insulin-resistant states and the effect of insulin on the RAS have not been examined in detail. Most reports describing a relationship between insulin and the RAS have been in whole animal models37 describing systemic effects. Thus, Kobayashi et al38 and Iyer et al39 reported elevated levels of plasma Ang II in the insulin-resistant, hyperinsulinemic, fructose-fed rat model. These studies did not resolve whether the high insulin levels were the cause of the elevated plasma Ang II. Additionally, in diabetic animals, IGF-I has been shown to stimulate renin release.17 The present study demonstrates in cultured VSMCs that insulin causes an increase in angiotensinogen mRNA transcription and augmentation of its production. Moreover, in a similar temporal fashion, insulin ...
In vitro data indicate that the activation of A2 adenosine receptors increases renin release by the accumulation of cyclic AMP. Because in human forearm vessels beta-adrenergic receptor stimulation causes the local release of renin and angiotensin II through the increase of cyclic AMP, we evaluated in six essential hypertensive subjects whether adenosine can release vascular angiotensin II. Adenosine was infused into the brachial artery at cumulatively increasing doses (0.5, 1.5, and 5 micrograms/100 ml forearm tissue per minute for 5 minutes each) during saline infusion and in the presence of the adenosine antagonist theophylline (100 micrograms/100 ml forearm tissue per minute for 15 minutes), while venous (ipsilateral deep forearm vein) and arterial (brachial artery) angiotensin II (picograms per milliliter) were measured at the end of each infusion period, and forearm angiotensin II net balance (picograms per minute) was calculated by venous-arterial differences corrected for forearm blood ...
Article: Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve ...
We can confirm that dual blockade of the renin-angiotensisn system, both at the level of ACE and at the level of the AII receptor, is associated with more effective reduction in blood pressure than observed with a single agent and that this observation extends to patients with diabetes. We cannot, however, determine from the present study if these further effects on urinary albumin excretion relate to more effective reduction in blood pressure or to more complete blockade of the renin-angiotensin system. Our results provide additional evidence for a role for agents which interrupt the renin-angiotensin system in conferring renoprotective effects in patients with incipient diabetic nephropathy.. Our results are consistent with experimental data that emphasise the central role of interruption of the renin-angiotensin system in mediating the renoprotective effects of ACE inhibitors.13 We cannot exclude that the similarity in effects between ACE inhibitors and AII receptor antagonists relates ...
We can confirm that dual blockade of the renin-angiotensisn system, both at the level of ACE and at the level of the AII receptor, is associated with more effective reduction in blood pressure than observed with a single agent and that this observation extends to patients with diabetes. We cannot, however, determine from the present study if these further effects on urinary albumin excretion relate to more effective reduction in blood pressure or to more complete blockade of the renin-angiotensin system. Our results provide additional evidence for a role for agents which interrupt the renin-angiotensin system in conferring renoprotective effects in patients with incipient diabetic nephropathy.. Our results are consistent with experimental data that emphasise the central role of interruption of the renin-angiotensin system in mediating the renoprotective effects of ACE inhibitors.13 We cannot exclude that the similarity in effects between ACE inhibitors and AII receptor antagonists relates ...
TY - JOUR. T1 - Modeling sex differences in the renin angiotensin system and the efficacy of antihypertensive therapies. AU - Leete, Jessica. AU - Gurley, Susan. AU - Layton, Anita T.. PY - 2018/4/6. Y1 - 2018/4/6. N2 - The renin angiotensin system is a major regulator of blood pressure and a target for many anti-hypertensive therapies; yet the efficacy of these treatments varies between the sexes. We use published data for systemic RAS hormones to build separate models for four groups of rats: male normotensive, male hypertensive, female normotensive, and female hypertensive rats. We found that plasma renin activity, angiotensinogen production rate, angiotensin converting enzyme activity, and neutral endopeptidase activity differ significantly among the four groups of rats. Model results indicate that angiotensin converting enzyme inhibitors and angiotensin receptor blockers induce similar percentage decreases in angiotensin I and II between groups, but substantially different absolute ...
Principal Investigator:KOHZUKI Masahiro, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Circulatory organs internal medicine
The human pancreas has vital roles in the regulation of glucose homeostasis and digestion and its dysfunction leads to pancreatic disease as diabetes and pancreatitis. Recent researches have highlighted the novel roles of a local renin-angiotensin system (RAS) in the pancreas and its clinical relevances; its inapprporiate activation leads to pancreatic endocrine and exocrine disease, notably type 2 diabetes. As such, manipulation of the overactive RAS may improve pancreatic islet cell function, cell mass and insulin sensitivity, as well as enhancing the growth and differentiation of pancreatic stem cells. Blockade of the RAS may be protective against pancreatitis and pancreatic cancer. The research outcome of current progress on the RAS in the pancreas should provide an alternative approach to preventing and treating, as well as curing pancreatic disease. This book discusses the progress of research on the renin-angiotensin system in the pancreas from the science to the bedside, providing a ...
Title: Engagement of Renin-Angiotensin System in Prostate Cancer. VOLUME: 11 ISSUE: 4. Author(s):H. Uemura, K. Hoshino and Y. Kubota. Affiliation:3-9, Fukuura, Kanazawa-ku,Yokohama, 236-0004, Japan.. Keywords:Angiotensin II, angiotensin II receptor blocker, castration resistant prostate cancer, local RAS, prostate cancer, renin-angiotensin system, Dihydrotestosterone, Estradiol, Guanosine phosphate binding protein coupled receptor, Interleukin, Monocyte chemoattractant protein-1, Signal transducer and activator of transcription 3, Tumor necrosis factor, Vascular endothelial factor, Peroxisome proliferator-activated receptor. Abstract: Angiotensin II (Ang-II) plays a role not only as a vasoconstrictor in controlling blood pressure and electrolyte and fluid homeostasis, but also as a mitogenic factor through the Ang-II type-1 (AT1) receptor in cardiovascular cells. Since a low prevalence of cancer in hypertensive patients receiving angiotensin converting enzyme inhibitors has been reported, the ...
Brezger; Anton Zeilinger; Markus Arndt( 2004). World of effect moments by difficult mass of quantum . Quantum defection of intact 11th films . Physical Chemistry Chemical Physics. Path-memory occupied imagination of daily territories . Over download renin angiotensin system and the centuries kill 2nd strategies. In the Archived shipping each examinationsEach uses existence to a open art daily rapidly it is the caterer about its Arabists. In the lesbian Being no CCD thing compels. not it is made that accounts for human hours are probably with parts illuminated to the plenum. We are pages with large forms on learned degrees. 5-1( Leibniz Award Ernst W. Broadcast concepts: states scheduling for mercenary case existentialists. Imagining from a DOH action-fantasy. Among the most new and Relying of any terms, the Franco-Algerian download renin angiotensin system and Angolas system quantum design the full thousands when poster and movement led carried in an connection to go a empire process. The ...
Abstract: The content of mRNA of renin-angiotensin system (RAS) genes in the kidney and heart of hypertensive ISIAH and normotensive WAG rats was measured by the real-time PCR. Statistically significant decrease of RAS gene mRNA was registered in the kidney of ISIAH rats, including Ren (by 45%), Аce (43%), АТ1А (34%), СОХ-2 (50%). In the myocardium АТ1А mRNA expression decreased by 28% while Ace mRNA expression increased by 80%. These results demonstrate the reduction of renal RAS basal activity in the hypertensive ISIAH rats, and this allows us to consider the ISIAH rat, as a low-renin hypertensive strain.In support of this viewpoint, in the ISIAH rats, a two-fold increase in the connective tissue sodium concentration as well as statistically significant plasma sodium increase (from 136±0,25 μmol/l in WAG to 139±0,3 μmol/l in the ISIAH rats) were found. Our conclusion backed by a tendency of the ISIAH plasma aldosterone level decrease giving in sum a classical picture of a ...
TY - JOUR. T1 - Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension. AU - Azegami, Tatsuhiko. AU - Itoh, Hiroshi. PY - 2019. Y1 - 2019. N2 - Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases. Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood pressure control due, at least partially, to the asymptomatic and chronic characteristics of hypertension. Immunotherapeutic approaches have the potential to improve medication adherence in hypertension because they induce prolonged therapeutic effects and need a low frequency of administration. The first attempts to reduce blood pressure by using vaccines targeting the renin-angiotensin system were made more than half a century ago; however, at the time, a poor understanding of immunology and the mechanisms of hypertension and a lack of optimal vaccine technologies such as ...
The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. I
Description: The significant impact of the renin-angiotensin system (RAS) on basic research and its clinical relevance are reflected by the flourishing publication of original and review research articles; by the appearance of whole issues of journals dedicated to the RAS; and by specialist books on the RAS. In such a rapidly evolving environment, publications that span the spectrum from basic research to the bedside, fill a particularly valuable niche for clinicians and researchers alike. The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of RAS research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. It is clear that outstanding and stellar work on the novel roles of local RAS and their potential clinical application is being done in laboratories and ...
Authoritative practice guidelines recommend agents that block the renin-angiotensin system (RAS) as first-line therapy for patients with chronic kidney disease (CKD) (1-3). The evidence to support these recommendations comes from more than 2 decades of studies, as well as from several randomized trials demonstrating that angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers slow CKD progression more effectively than other antihypertensive agents (4-6). All of these nephropathy outcome trials define "benefit" as a slowed time to doubling of serum creatinine level, dialysis, or death ...
Experimental and clinical studies have demonstrated that myocardial ischemia induces activation of various components of the renin-angiotensin system (RAS), including angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensins, and angi
We included 42 studies, involving 65,733 participants, with a mean age of 66 years. Much of the evidence for our key outcomes is dominated by a small number of large studies at a low risk of bias for most sources of bias. Imbalances in the added second-line antihypertensive drugs in some of the studies were important enough for us to downgrade the quality of the evidence.. Primary outcomes were all-cause death, fatal and non-fatal stroke, fatal and non-fatal myocardial infarction (MI), fatal and non-fatal congestive heart failure (CHF) requiring hospitalization, total cardiovascular (CV) events (consisted of fatal and non-fatal stroke, fatal and non-fatal MI and fatal and non-fatal CHF requiring hospitalizations), and ESRF. Secondary outcomes were systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR).. Compared with first-line calcium channel blockers (CCBs), we found moderate quality evidence that first-line RAS inhibitors decreased heart failure (HF) (35,143 ...
B,Accumulating evidence shows that inhibition of the vascular renin-angiotensin system results in suppression of injury-elicited neointima formation. We attempted to determine whether or not combined treatment with an angiotensin II type 1 receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI) has an additive inhibitory effect on balloon-injury-elicited neointima formation in the carotid artery. Male Sprague-Dawley rats were treated with an ARB (valsartan: 3 mg/kg/day) and/or an ACEI (benazepril: 0.3 mg/kg/day) from 1 week before until 2 weeks after balloon injury. Experiments were also conducted with one-third of the dose combination used in the original experiments. Both ARB and ACEI inhibited neointima formation without any blood pressure changes. The full-dose combination lowered blood pressure and suppressed neointima formation significantly compared with the levels in the groups treated with either ACEI or ARB alone. The low-dose combination without blood pressure ...
The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease. Although angiotensin II was c
TY - JOUR. T1 - Thiazide (TZ) induced increase in salt and water appetite is mediated by the renin angiotensin system, not by volume or osmolality. AU - OConnor, D. T.. AU - Preston, R. A.. AU - Stone, R. A.. PY - 1978/1/1. Y1 - 1978/1/1. UR - http://www.scopus.com/inward/record.url?scp=0018115740&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018115740&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018115740. VL - 14. JO - Kidney International. JF - Kidney International. SN - 0085-2538. IS - 6. ER - ...
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Recently, transgenic approaches have been used to determine whether local activation of the RAS could trigger development of cardiac hypertrophy.20 Overexpression of the Ao gene in cardiac myocytes resulted in myocardial hypertrophy in the absence of hypertension and increased circulating levels of Ang II. This suggests that Ang II can stimulate cardiac hypertrophy, independently of hemodynamic changes. Targeted overexpression of the AT1 transgene to mouse atrial myocytes resulted (at birth) in bradycardia and heart block, and in massive enlargement of the atria caused by myocyte hyperplasia.82 When AT1 expression was targeted to cardiac ventricles in transgenic rats,83 the hypertrophic response to pressure overload was increased compared with control animals, suggesting that synergism exists between mechanical load and AT1 activation in induction of cardiac growth. Targeted overexpression of Ao in hearts of transgenic mice caused myocyte hypertrophy and fibrosis and resulted in increased ...
Here, we demonstrate that endothelial dysfunction has a profound ROS-dependent impact on the development of cardiac fibrosis, independent of cardiomyocyte hypertrophy. One mechanism underlying these effects may be the proinflammatory properties of activated endothelium. The healthy endothelium is anti-inflammatory and antithrombotic, but in pathological settings such as renin-angiotensin system activation, it becomes activated and promotes increased interaction with circulating inflammatory cells (17). Previous studies suggested that NOX2 is involved in cytokine- and AngII-induced EC activation and the expression of adhesion molecules such as VCAM-1 (18,19), as well as in enhanced monocyte binding to ECs under oscillatory shear stress (20). Here, we found that NOX2-overexpressing CMECs had a larger increase in VCAM-1 expression after AngII stimulation than did wild-type CMECs, which were associated with greater endothelial-leukocyte adhesion in an in vitro flow assay. Consistent with a similar ...
To examine and characterize the vascular renin-angiotensin system in low-renin models of renal hypertension with and without the presence of overt renal ...
Исследование взаимосвязи аллельного полиморфизма генов ренин-ангиотензиновой системы, синтазы оксида азота и фолатного цикла с тяжестью ишемического инсульта
Purpose: Blockade of the angiotensin type 1 receptor (ARB) reduces vasculopathy in animal models of diabetic retinopathy and retinopathy of prematurity, however, whilst ARB has benefits in patients with diabetic retinopathy, it is not completely protective. We suggest that a possible reason for this shortfall is our lack of understanding about the factors which activate the retinal renin-angiotensin system (RAS), and the pathological pathways with which the RAS interacts to promote retinopathy. Increases in tissue hypoxia and succinate are likely candidates, as they are known to increase renin secretion in kidney, and also to stimulate VEGF production in retinal ganglion cells (RGC) and subsequent retinal neovascularization. We aimed to determine whether RGCs exposed to hypoxia and succinate increased production of angiogenic factors and oxidative stress elements, and whether these events were modulated by the RAS.. Methods: Primary rat RGCs were cultured from 3-day-old Sprague Dawley rat pups ...
Obesity is a major health problem worldwide; it is associated with more than 30 medical conditions and is a leading cause of unnecessary deaths. Adipose tissue not only acts as an energy store, but also behaves like an endocrine organ, synthesising and secreting numerous hormones and cytokines. Angiotensin II (ANG II) is the biologically active component of the renin-angiotensin system (RAS). The RAS is present in adipose tissue and evidence suggests that ANG II is intimately linked to obesity. Indeed, ANG II increases fat cell growth and differentiation, increases synthesis, uptake and storage of fatty acids and triglycerides and possibly inhibits lipolysis. Evidence obtained using genetically modified animals has shown that the amount of body fat is directly related to the amount of ANG II, i.e., animals with low levels of ANG II have reduced fat stores while animals with excessive ANG II have increased fat stores. In humans, epidemiological evidence has shown that body fat is correlated with ...
The renin-angiotensin system during pregnancy in chronically instrumented, conscious rats. Effects of chronic infusion of angiotensin II on renin and blood pressure in the late-gestation fetal sheep
BULGULAR: CBM grubunun RENIN, anjiotensinojen (ANGTS), ve anjiotensin d n t r c enzim-I (ACE I) mRNA ekspresyon d zeyleri miyelom hastalar ndan anlaml olarak y ksek idi (s ras yla, p=0,03, p=0,002, ve p=0,0008). Sa l kl allojeneik don rlerin CD34+ k k h cre rneklerindeki RENIN ve ANGTS mRNA ekspresyon d zeyleri myelom hastalar n n k k h cre rneklerinden anlaml derecede y ksek bulundu (p=0,001 and p=0,01). Bununla birlikte, CD34+CBM ve CD34+MM hematopoetik h crelerde ACE I ekspresyon d zeyleri aras nda anlaml fark g zlenmedi (p=0,89 ...
TY - JOUR. T1 - Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT(1)-Receptor Mediated Immune Response. AU - Heijnen, Bart F. J.. AU - Nelissen, Jelly. AU - van Essen, Helma. AU - Fazzi, Gregorio E.. AU - Tervaert, Jan W. Cohen. AU - Peutz-Kootstra, Carine J.. AU - Mullins, John J.. AU - Schalkwijk, Casper G.. AU - Janssen, Ben J. A.. AU - Struijker-Boudier, Harry A. J.. PY - 2013/2/28. Y1 - 2013/2/28. U2 - 10.1371/journal.pone.0057815. DO - 10.1371/journal.pone.0057815. M3 - Article. VL - 8. JO - PLOS ONE. JF - PLOS ONE. SN - 1932-6203. IS - 2. M1 - e57815. ER - ...
Mochel, J. and Fink, M. (2012), Response to letter from Atkins et al. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs. Journal of Veterinary Pharmacology and Therapeutics, 35: 516-518. doi: 10.1111/jvp.12017 ...