TY - JOUR. T1 - American Registry of Pathology Expert Opinions. T2 - Immunohistochemical evaluation of classic Hodgkin lymphoma. AU - OMalley, Dennis P.. AU - Dogan, Ahmet. AU - Fedoriw, Yuri. AU - Medeiros, L. Jeffrey. AU - Ok, Chi Young. AU - Salama, Mohamed. PY - 2019/4/1. Y1 - 2019/4/1. N2 - The diagnosis of classic Hodgkin lymphoma requires immunohistochemical confirmation in most cases and one can argue for these studies as standard-of-care in the diagnostic workup. The authors propose a panel of studies for primary identification of CHL to include: CD3, CD20, CD15, CD30 and PAX5. When pattern discordances are identified, additional assessment is recommended. In the case of overexpression of B lineage markers by Hodgkin/Reed-Sternberg cells, or a differential diagnosis that includes large B-cell lymphoma or variants, additional markers recommended are: CD45, OCT2, BOB1, CD79a and MUM1/IRF4. If primary mediastinal large B cell lymphoma is considered in the differential diagnosis, suggested ...

Derivation of H/RS cells from mature B cells was previously demonstrated in 18 out of 18 informative unselected cases of cHD analyzed in Cologne and Frankfurt (3)(4)(5)(17)(18)(19). In addition, recent results obtained by others indicate B cell derivation of H/RS cells in 24 out of 25 cases of cHD (20). On the other hand, in a nonselected collection of 13 cases of primary cHD, Daus and colleagues did not detect clonal TCR-γ gene rearrangements in micromanipulated H/RS cells from any of these cases (21). Therefore, these data collectively indicate that cHD represents a homogenous entity as a B cell lymphoma.. However, there are some observations raising the possibility that-in a subset of cHD-the tumor cells might stem from T lymphocytes. Some putative H/RS cell lines, for example, are derived from T cells (2). For these cell lines, proof of derivation from H/RS cells in the patients is missing. Furthermore, a TCR-α gene rearrangement was amplified from whole tissue DNA of lymphomatoid ...

Leukemia & Lymphoma (Contd.) Disease Cause/Risk Factors Symptoms Buzzwords Other Cervical, Supraclavicular or mediastinal nodes Lacunar Reed Sternberg Cells Hodgkins Disease Most common type; affects adolescent or young adult women EBV Variable cell composition & necrosis Collagen Bands (Nodular Sclerosis) Staging (usually I or II) determines treatment; Good prognosis CD15 & CD30 Women Variable cell composition & focal necrosis Hodgkins Disease Disordered fibrosis 2ndEBV Classic Reed Sternberg Cells most common type; men more common (Mixed Cellularity) Eosinophils, Plasma & T Cells Staging determines treatment; Guarded prognosis CD15 & CD30 1) Diffuse Fibrosis - RS Cells embedded in Fairly common - usually in older patients Poor Prognosis Hodgkins Disease fibrous stroma Often Bone Marrow Involvement (Stage III or IV) EBV Many Reed Sternberg Cells (Lymphocyte Depletion) 2) Reticular - RS Cells in sheets Poor prognosis Bone Marrow ? #s of Reed Sternberg Cells Usually not a true Hodgkins ...

CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody, Mouse Monoclonal Antibody [Clone SPM121 ] validated in IHC, IF, FC (AH12690-7), Abgent

CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone Ki-1/779 ] validated in IHC, IF, FC (AH12693-100), Abgent

Nodular sclerosis (or NSHL) is a form of Hodgkins lymphoma that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands. ...

CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. The presence of these cells is diagnostic of Hodgkins lymphoma. Reed-Sternberg cells display a characteristic pattern of CD15 positivity, with membranous staining combined with staining of the Golgi apparatus. Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells. CD15 is also present in about 50% of adenocarcinoma cells and can be used to distinguish such conditions from mesothelioma, which is typically negative.[4]. ...

Purpose: There is evidence that Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) could display some molecular and morphologic markers of cellular senescence (CS). We hypothesized that CS mechanisms may have potential prognostic relevance in cHL and investigated whether the expression of the well-established CS biomarkers p21CIP1/WAF1 and p16INK4a by HRS cells might be predictive of the probability of event-free survival (EFS).. Experimental Design: The study analyzed a retrospective cohort of 147 patients and the results were validated on a cohort of 91 patients independently diagnosed and treated in a different institution. p16INK4a and p21CIP1/WAF1 were categorized as dichotomous variables (, or ≥ 30% of HRS cells at diagnosis) and evaluated in univariate and multivariate analysis.. Results: Both molecules were independent prognostic factors. A positive staining of one of the two molecules in more than 30% HRS cells predicted a better EFS (P , 0.01). ...

摘要The malignant Hodgkin/Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) are believed to derive from germinal center (GC) B cells, but lack expression of a functional B cell receptor. As apoptosis is the normal fate of B-cell receptor negative GC B cells, mechanisms that abrogate apoptosis are thus critical in HL development, such as epigenetic disruption of certain pro-apoptotic cancer genes including tumor suppressor genes. Identifying methylated genes elucidates oncogenic mechanisms and provides valuable biomarkers; therefore, we performed a chemical epigenetic screening for methylated genes in HI. through pharmacological demethylation and expression profiling. IGST4/CADM1/TSLC1, a pro-apoptotic cell adhesion molecule of the immunoglobulin superfamily, was identified together with other methylated targets. In contrast to its expression in normal GC B cells, IGSF4 was down-regulated and methylated in cell lines, most primary HL, and microdissected HRS cells of 3/5 cases, but not in ...

AFM13 is a RECRUIT-TandAb (CD30xCD16A) for treating Hodgkin Lymphoma by recruiting NK-cells and macrophages to the specific CD30 surface antigen on Reed-Sternberg cells. This redirected immune response leads to potent tumor cell killing. RECRUIT TandAbs are tetravalent and bispecific, and address key deficiencies of monoclonal antibodies such as (i) differential binding to V/F allotypes of CD16A receptor and (ii) non-selective binding to activating CD16A and non-signalling CD16B receptors. Furthermore, RECRUIT-TandAbs have significant advantages over other antibody fragment technologies such as (i) bivalent binding to the targets and, (ii) longer half-life.. AFM13 binds with high affinity to both CD30 and CD16A and is able to rapidly induce lysis of CD30+ cells at picomolar concentrations in the presence of PBMCs. Intensive in vitro characterization demonstrated that AFM13 is specific for the CD16A receptor, which becomes activated only in the presence of tumor cells: there is no systemic ...

The malignant Hodgkin/Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) are believed to derive from germinal center (GC) B cells, but lack expression of a functional B cell receptor. As apoptosis is the normal fate of B-cell receptor negative GC B cells, mechanisms that abrogate apoptosis are thus critical in HL development, such as epigenetic disruption of certain pro-apoptotic cancer genes including tumor suppressor genes. Identifying methylated genes elucidates oncogenic mechanisms and provides valuable biomarkers; therefore, we performed a chemical epigenetic screening for methylated genes in HI. through pharmacological demethylation and expression profiling. IGST4/CADM1/TSLC1, a pro-apoptotic cell adhesion molecule of the immunoglobulin superfamily, was identified together with other methylated targets. In contrast to its expression in normal GC B cells, IGSF4 was down-regulated and methylated in cell lines, most primary HL, and microdissected HRS cells of 3/5 cases, but not in normal ...

Lymphoma refers to a family of cancers of the lymphatic system, which includes the parts of the immune system responsible for fighting disease and infection. Lymphomas are divided into two categories, Hodgkins and non-Hodgkins.. Hodgkins lymphoma, also known as HL, is a cancer that begins in lymphocytes, the white blood cells responsible for immune system responses. HL begins when a lymphocyte (usually a B cell) becomes abnormal, with the presence of a particular abnormal cell called a Reed-Sternberg cell. (See photo below.). The Reed-Sternberg cell divides to make copies of itself. The new cells divide again and again, making more and more abnormal cells. The abnormal cells dont die when they should, and they dont protect the body from infections or other diseases. Instead, the buildup of extra cells often forms a mass of tissue called a growth or tumor.. HL can start almost anywhere in the body because of the extensive reach of the lymphatic system. Usually, HL is first found in a lymph ...

Clone REA1085 recognizes the human CD30 antigen, a cell membrane protein, which is a member of the tumor necrosis factor receptor (TNFR) superfamily, and also known as Ki-1. CD30 is used as a tumor marker and is found on Hodgkin/Reed-Sternberg (H/RS) cells, embryonal carcinoma cells, and on activated T and B lymphocytes. It functions as a receptor for TNFSF8/CD30L and is involved in the regulation of cellular growth and transformation of activated lymphoblasts and regulates signal transduction by activation of NF-κB. Additional information: Clone REA1085 displays negligible binding to Fc receptors. - USA

CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkins disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkins and Reed-Sternberg cells, CD30 is also found in some non-Hodgkins lymphomas (including Burkitts lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 ...

The metabolic properties of lymphomas derived from germinal center (GC) B cells have important implications for therapeutic strategies. In this study, we have compared metabolic features of Hodgkin-Reed-Sternberg (HRS) cells, the tumor cells of classical Hodgkins lymphoma (cHL), one of the most frequent (post-)GC-derived B-cell lymphomas, with their normal GC B cell counterparts. We found that the ratio of oxidative to nonoxidative energy conversion was clearly shifted toward oxidative phosphorylation (OXPHOS)-linked ATP synthesis in HRS cells as compared to GC B cells. Mitochondrial mass, the expression of numerous key proteins of oxidative metabolism and markers of mitochondrial biogenesis were markedly upregulated in cHL cell lines and in primary cHL cases. NFkappaB promoted this shift to OXPHOS. Functional analysis indicated that both cell growth and viability of HRS cells depended on OXPHOS. The high rates of OXPHOS correlated with an almost complete lack of lactate production in HRS cells ...

The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13134-9 ...

A 25-year-old male with an existing diagnosis activated his CancerCARE benefit. The patient reported a diagnosis of a rare, high-risk subtype of Hodgkins disease. The patient was receiving treatment for this initial diagnosis. Upon activating his CancerCARE® benefit, the patients samples were sent to a Center of Excellence for diagnosis confirmation. The second opinion determined that the patient had classical Hodgkins disease, not the high-risk diagnosis he originally received. With CancerCAREs help, the patients treatment was adjusted and his overall outcome was improved.. ...

The epidemiology of Hodgkins disease suggests that it is a heterogeneous condition comprising more than one disease entity. The Epstein-Barr virus (EBV) is present in the Reed-Sternberg cells of a proportion of cases and is likely to play a role in the pathogenesis of these cases. In this study we …

Definition: Acral myxoinflammatory fibroblastic sarcoma is a rare tumor of the distal extremities. It is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed-Sternberg-like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood ...

Etiology, pathophysiology and prognostic factors of Hodgkins Lymphoma (HD) Slightly more common in males than females (peaks around 15-30 & | 65) Risk factors are largely unknown but HIV, EBV, chromosomal abnormalities & familial history may all lay a factor Reed-Sternberg cells (multi-nucleated giant cell--malignant B cells) express CD30 & CD15 Prognostic factors: Serum albumin…

Clinical Definition Hodgkin disease, or Hodgkin s disease, is a malignant neoplasm of lymphoid cells and is one type of lymphoma. It differs from other lymphomas in that it produces abnormal Reed-Sternberg cells. It is characterized by enlargement of the lymph nodes, spleen and possibly liver. Hodgkin disease is divided into two main subtypes based on…. ...

A 49-year-old man presented with a 2-year history of an enlarging ulcerated plaque over the right forearm with an associated history of pruritus. Skin biopsy demonstrated an infiltrate of lymphocytes in the dermis and subcutis, together with atypical cells with large nuclei and prominent nucleoli resembling Reed-Sternberg cells.

DIAGNOSING LYMPHOMA AND THE GMCHMDS. INTRODUCTION TOTHE NATURE AND MANAGEMENT OF LYMPHOMA. Dr Andrew J Norton. Thomas Hodgkin 1798-1866. Case 4: Thomas Westcott. Samuel Wilks 1824-1911. Carl von Sternberg 1872-1935. Reed-Sternberg cell or Sternberg-Reed cell. Slideshow 257486 by conroy

CD30 is a member of the tumor necrosis factor (TNF) receptor family, originally described as a marker for Hodgkin and Reed-Sternberg cells in Hodgkins disease, which has been found to be preferentially expressed by T cells producing Th2-type cytokines. The presence of CD30 expression was assessed by both immunohistochemistry and reverse transcriptase-polymerase chain reaction in the target organs (if patients with Th1- or Th2-dominated disorders. CD30 expression was found in neither the gut of patients with Crohns disease nor in the gastric antrum of Helicobacter pylori-infected patients, where there was high interferon-gamma (IFN-gamma) expression. In contrast, high CD30 expression in the apparent absence of IFN-gamma expression was observed in the skin of patients with systemic sclerosis or chronic graft versus host disease (GVHD), which can be considered Th2dominated disorders. Moreover, high levels of soluble CD30 were found in the serum of both systemic sclerosis and GVHD patients but not ...

Antigen Background The CD74 molecule has several isoforms (33, 35 and 41 kD) and is the invariant chain of HLA-DR. The protein is reported to be expressed in B cell lymphomas, leukemias, Reed Sternberg cells and Hodgkins mononuclear cells. The expression of CD74 protein occurs before the pre-B cell stage and is lost before the plasma cell stage. Product Specific Information NCL ...

In this issue of Blood, Fhu et al report that Reed-Sternberg cell-derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (cHL), a process that is...

Human KLHDC3 partial ORF ( NP_476502, 1 a.a. - 102 a.a.) recombinant protein with GST-tag at N-terminal. (H00116138-Q01) - Products - Abnova

Complete information for KLHDC8A gene (Protein Coding), Kelch Domain Containing 8A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Identification of a small HRS population in a clinical sample: malignant HRS cells shown in red have increased forward scatter area (FSC-A) and height (FSC-H)

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Preclinical studies suggest that HRS cells evade immune detection by exploiting the pathways associated with immune checkpoint, Programmed Death-1 (PD-1) and its ligands PD-L. Classical Hodgkin Lymphoma is an excellent example of how the tumor microenvironment influences cancer cells to proliferate and survive. The most common genetic abnormality in Nodular sclerosis subtype of Hodgkin lymphoma is the selective amplification of genes on the short arm of chromosome 9 (9p24.1) which includes JAK-2, with resulting increased expression of PD-1 ligands such as PDL1 and PDL2 on HRS cells, as well as increased JAK-STAT activity, essential for the proliferation and survival of Hodgkin Reed-Sternberg (HRS) cells. Infection with Epstein-Barr virus (EBV) similarly can increase the expression of PDL1 and PDL2 in EBV-positive Hodgkin lymphomas. It would therefore seem logical to block or inhibit immune check point PD-1 rather than both its ligands, PDL1 and PDL2.. Immune checkpoints are cell surface ...

PURPOSE: Classic Hodgkin lymphoma is highly curable with contemporary therapy. Although the limited role of surveillance imaging to detect early relapse for patients in complete remission at the end of therapy is well established, there is a paucity of data regarding role of laboratory testing in this setting.. METHODS: Patients with newly diagnosed classic Hodgkin lymphoma uniformly treated with the Stanford V regimen from 1998-2014 and in complete remission for at least 3 months were identified in a single-center institutional database. Laboratory tests categorized by Common Terminology Criteria for Adverse Events v4.03 as grade 2 or higher were considered abnormal. Primary analysis included sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of surveillance laboratory tests for predicting relapse in the first 3 years after end of treatment.. RESULTS: Among 235 eligible patients, 24 (10.2%) patients ultimately relapsed. In the first 3 years after end ...

Hodgkin lymphoma is cancer that begins in the lymph system in white blood cells called lymphocytes. When these cells become abnormal, they grow without control and may form lumps of tissue called tumors.. The most common type of Hodgkin lymphoma is called classical Hodgkin lymphoma. The cancerous tumors (lymphomas) in classical Hodgkin lymphoma contain Reed-Sternberg cells. Non-Hodgkin lymphomas dont have these cells.. Symptoms of Hodgkin lymphoma include enlargement of the lymph nodes, fever, appetite loss, weight loss, and night sweats.. Hodgkin lymphoma affects men more often than women. The cause of Hodgkin lymphoma is not known.. Treatment for Hodgkin lymphoma depends on the stage of the lymphoma and may include radiation or chemotherapy.. ...

The ICD-10 Code C81.73 is the code used for Oth classical Hodgkin lymphoma, intra-abdominal lymph nodes .An alternative description for this code is Other classical Hodgkin lymphoma, intra-abdominal ...

Tryptase is the most abundant protease in human mast cells, and is often used as a marker for the enumeration of mast cells in tissue. Here we report that tumour cells from Hodgkin lymphoma, the so called Hodgkin and Reed-Sternberg cells, can express tryptase. Hodgkin lymphoma cell lines expressed mRNA for both alpha- and beta-tryptase and also produced the protein, although at much lower concentrations than mast cells. However, the frequency of tryptase positive HRS-cells in situ was very low. This report demonstrates that tumour cells of lymphoid origin can express tryptase in vitro and in situ.. ...

Nodular lymphocyte predominant Hodgkins lymphoma (NLPHL) is an indolent CD20(+) form of lymphoma. Some people no longer classified it as a form of classic Hodgkins lymphoma (HL). This is because the Reed-Sternberg cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkins lymphoma with encouraging results. BCL6 gene rearrangements have ...

Researchers have sequenced the genomes of 10 patients with classical Hodgkin lymphoma (cHL), cataloging the mutations in the Reed-Sternberg (RS) cells that characterize cHL.

steveo - Survivor: Hodgkin Disease > Classic Hodgkin Disease > Nodular sclerosing Patient Info: Finished active treatment more than 5 years ago, Diagnosed: almost 18 years ago, Male, Age: 32

TY - JOUR. T1 - Nivolumab for the treatment of classical Hodgkin lymphoma after failure of autologous stem cell transplant and brentuximab. AU - Villasboas Bisneto, Jose (J.C.). AU - Ansell, Stephen Maxted. PY - 2016/1/2. Y1 - 2016/1/2. N2 - Cancer cells are able to escape surveillance from the immune system by co-opting physiologic mechanisms such as the programmed cell death-1 (PD-1) receptor pathway. Agents able to block the interaction between the PD-1 receptor and its ligands have the potential to release T cells from tumor-induced suppression and eradicate malignant cells. Nivolumab-a PD-1 inhibitor-is approved for the treatment of patients with metastatic melanoma and lung cancer. This agent has been tested in patients with advanced Hodgkin lymphoma (HL) and showed impressive results in a phase I trial. Here we review the profile of Nivolumab including its pharmacological properties, clinical efficacy and safety in patients with advanced classical HL.. AB - Cancer cells are able to escape ...

cHL: Evaluation of 1,450 patients - Higher Absolute Monocyte Count (AMC) is poor predictor of 5-year PFS and 5-year OS in patients with Nodular Sclerosis (NS) classical Hodgkin Lymphoma

TY - JOUR. T1 - Pembrolizumab monotherapy in patients with primary refractory classical hodgkin lymphoma who relapsed after salvage autologous stem cell transplantation and/or brentuximab vedotin therapy. T2 - KEYNOTE-087 subgroup analysis. AU - Zinzani, Pier Luigi. AU - Chen, Robert. AU - Armand, Philippe. AU - Johnson, Nathalie A.. AU - Brice, Pauline. AU - Radford, John. AU - Ribrag, Vincent. AU - Molin, Daniel. AU - Vassilakopoulos, Theodoros P.. AU - Tomita, Akihiro. AU - von Tresckow, Bastian. AU - Shipp, Margaret A.. AU - Lin, Jianxin. AU - Nahar, Akash. AU - Balakumaran, Arun. AU - Moskowitz, Craig H.. PY - 2020/3/20. Y1 - 2020/3/20. UR - http://www.scopus.com/inward/record.url?scp=85078638645&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85078638645&partnerID=8YFLogxK. U2 - 10.1080/10428194.2019.1702178. DO - 10.1080/10428194.2019.1702178. M3 - Letter. C2 - 31905294. AN - SCOPUS:85078638645. VL - 61. SP - 950. EP - 954. JO - Leukemia and Lymphoma. JF - Leukemia ...

Evidence-based recommendations on pembrolizumab (Keytruda) for treating relapsed or refractory classical Hodgkin lymphoma (cHL) in adults

MSD’s anti-PD-1 therapy Keytruda has taken a giant leap towards being approved in Europe for the treatment of classical Hodgkin Lymphoma (cHL). - News - PharmaTimes

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

TJMayer - Patient: Hodgkin Disease > Nodular lymphocyte predominant Hodgkin disease Patient Info: Living with cancer as a chronic illness (undergoing adjuvant therapy), Diagnosed: almost 11 years ago, Male, Age: 61, Stage III

54 NCCN Guidelines for Patients ® Hodgkin Lymphoma, Version 1.2015 4 Treatment guide: Classical Hodgkin lymphoma Review Review • First-time treatment for classic Hodgkin lymphoma almost always consists of chemotherapy and radiation therapy. Sometimes, chemotherapy alone is given if it works really well. More chemotherapy is given to cancers that are larger or more widespread. • Refractory cancer is cancer that isnt cured during first-time treatment. Chemotherapy is often first used for treatment. If the cancer responds well, you may have a stem cell transplant with or without radiation therapy. If the cancer responds less well, you may receive other drug treatments with or without radiation therapy. Radiation therapy alone is also an option to treat refractory disease following chemotherapy. • A relapse is cancer that re-appears on tests after a cancer-free period. Treatment options for stage IA or IIA depend on whether you had radiation therapy before. If not, chemotherapy with or ...

Definition Hodgkin lymphoma Hodgkin lymphoma is a cancer of a sub-type of white blood cells called Lymphocytes. Hodgkin lymphoma starts in abnormal B cells called Hodgkin and Reed-Sternberg cells. These... ...

Hodgkin lymphoma is a rare cancer known in the past as Hodgkins Disease that accounts for less than 1% of all cancer cases in the United States. Hodgkin lymphoma develops from B lymphocytes, a type of white blood cell that normally produces proteins called antibodies that fight infection. Lymphocytes can be found in lymphoid tissue, which can be found throughout the body, in the lymph nodes, bone marrow, spleen, thymus, and digestive tract. Hodgkin lymphoma usually first starts in lymph nodes in the chest, neck, or underarms. However, Hodgkin lymphoma can also develop in other lymph nodes or lymphoid tissue in other parts of the body. It can also spread through the lymph system or bloodstream to other organs and parts of the body. The cancerous lymphocytes of Hodgkin lymphoma are called Reed-Sternberg cells, which look and behave differently than do normal lymphocytes and non-Hodgkin lymphoma cells. There are two primary categories of Hodgkin lymphoma: classical and ...

Researchers from the Dana-Farber Cancer Center have confirmed prior studies that indicate chemotherapy alone is safe and effective for the treatment of early-stage Hodgkins Lymphoma in appropriate patients. The details of this study were published in a recent issue of the Journal of Clinical Oncology.[1]. Hodgkins lymphoma is a cancer of the lymph system and is diagnosed by the identification of a characteristic cell under the microscope (the Reed-Sternberg cell). Hodgkins lymphoma typically begins in the lymph nodes in one region of the body and then spreads through the lymph system in a predictable manner. It may spread outside the lymph system to other organs such as the lungs, liver, bone, and bone marrow.. Localized Hodgkins lymphoma can be treated with chemotherapy, radiation therapy, or the combination of these approaches. These treatments cure many patients, but the long-term side effects of treatment are an ongoing focus of research. The optimal therapy that cures the most patients ...

Nodular sclerosis. This form is most common in young adults and sometimes occurs in adolescents and even children. It is characterized by two pathologic findings: 1) the presence of a particular type of Reed-Sternberg cell variant, the lacunar cell (Fig. 23-1A), and 2) the presence of large bands of collagen that are deposited by reactive fibroblasts. The reactive background consists of a variable mixture of lymphocytes (mainly T cells), granulocytes (particularly eosinophils), macrophages, and plasma cells. The nodular sclerosis subtype is only rarely associated with Epstein-Barr virus (EBV). ...

Hodgkins lymphoma, also known as Hodgkin lymphoma and previously known as Hodgkins disease, is a type of lymphoma, which is a cancer originating from white blood cells called lymphocytes.. It was named after Thomas Hodgkin, who first described abnormalities in the lymph system in 1832.[1][2]. Hodgkins lymphoma is characterized by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. When Hodgkins cells are examined microscopically, multinucleated Reed-Sternberg cells (RS cells) are the characteristic histopathologic finding.. Hodgkins lymphoma may be treated with radiation therapy, chemotherapy, or hematopoietic stem cell transplantation, with the choice of treatment depending on the age and sex of the patient and the stage, bulk, and histological subtype of the disease. The disease occurrence shows two peaks: the first in young adulthood (age 15-35) and the second in those over 55 years old.[3]. The overall ...

The bispecific monoclonal antibody (Bi-MAb) HRS-3/AP-1 was developed by somatic hybridization of the 2 mouse hybridoma cell lines HRS-3 and AP-1, which produce monoclonal antibodies with reactivity against the Hodgkins- and Reed-Sternberg cell-associated CD30 antigen and alkaline phosphatase, respectively. After an active incubation with alkaline phosphatase, purified whole immunoglobulin molecules and F(ab′)2 fragments of the Bi-MAb were equally effective in converting a relatively noncytotoxic prodrug, mitomycin phosphate (MOP), into mitomycin alcohol, which was 100 times more toxic to the Hodgkins- and Reed-Sternberg cell line L540 (CD30+) than MOP. The cytotoxic activity of MOP was unaffected when the cells were pretreated with either the Bi-MAb or the enzyme alone. The Bi-MAb HRS-3/AP-1 did not bind to HPB-ALL cells (CD30-) and was not able to activate MOP on these cells. In cocultivation experiments with HPB-ALL and L540 cells, the activation of MOP by the Bi-MAb HRS-3/AP-1 and ...

article{f1d460a6-1694-4cd3-a657-b01df9443c91, abstract = {,p,Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent CD20,sup,+,/sup, lymphoma. Its scarcity has made clinical trials difficult and there is no consensus on first-line treatment. We conducted a population-based study of all patients diagnosed with NLPHL in Sweden between 2000 and 2014 (N = 158; 41 women and 117 men), focusing on clinical features, therapy and overall survival. The median female and male age was 59 and 44 years, respectively (P = 0·002). In early-stage disease, there was little mortality and no survival differences between therapies. In patients with advanced-stage disease, mortality was relatively high in patients who did not receive first-line rituximab but absent in those who did (10-year survival, 55% vs. 100%; P = 0·033); there were no imbalances of prognostic factors between those two groups. In advanced stages, first-line rituximab use increased markedly between 2000-2004 and 2005-2014 (7% vs. ...

Answer: There were several updates of both company-sponsored (e.g. the AETHERA trial) and investigator developed prospective clinical trials that further indicate the efficacy and safety of the use of brentuximab vedotin in patients with relapsed / refractory (r/r) Hodgkin lymphoma. The results of these studies will further improve the outcome of r/r Hodgkin lymphoma patients.. Question: What are the benefits of these engineered and complex novel drugs in the treatment of Hodgkin lymphoma and other cancers?. Answer: They represent a completely different way to treat patients with Hodgkin lymphoma (and other types of hematological malignancies that express the CD30 antigen in the cell surface). It represents a very intelligent way to deliver high doses of a very potent cytotoxic agent without giving the patient significant toxicity.. CD30 is a cell surface antigen expressed on malignant HL Reed-Sternberg cells and targeted by brentuximab vedotin, which comprises a CD30-targeted monoclonal ...

Nodular Lymphocyte-Predominant Hodgkin Lymphoma. Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) accounts for about 5% of cases. The cancer cells in NLPHL are large cells called popcorn cells (because they look like popcorn), which are variants of Reed-Sternberg cells. You may also hear these cells called lymphocytic and histiocytic (L&H) cells. NLPHL usually starts in lymph nodes in the neck and under the arm. It can occur in people of any agge, and is more common in men than women. This type of Hodgkin lymphoma tends to grow more slowly and is treated differently from the classic types.. ...

formerly called |b>non-Hodgkins lymphoma|/b>. A cancer of the|i> |/i>lymphatic system (a network of thin vessels and nodes throughout the body that serves as part of the immune system). The difference between non-Hodgkin lymphoma and Hodgkin disease is the Reed-Sternberg cell|i>,|/i> which is absent in non-Hodgkin lymphoma cells. See also |b>Hodgkin disease|/b>, |b>immune system|/b>, |b>lymphatic system|/b>.

Background. Reports dealing with clinical outcomes of classical Hodgkins lymphoma in low- to middle-income countries are scarce and response to therapy is poorly documented. This report describes the characteristics and clinical outcomes of patients with classical Hodgkins lymphoma from a single institution in Latin America.. Method. A retrospective study was conducted over ten years of patients with classical Hodgkins lymphoma treated at a referral center. Progression-free and overall survival rates were estimated by Kaplan-Meier analysis. The univariate Cox regression model was used to estimate associations between important variables and clinical outcomes.. Main results. One hundred and twenty-eight patients were analyzed. The mean age was 28.5 years. The five-year progression-free and overall survival were 37.3% and 78.9%, respectively. Of the whole group, 55 (43%) were primary refractory cases. Only 39/83 (47%) patients with advanced disease vs. 34/45 (75.6%) in early stages ...

Increased synthesis of IgG in vitro has been demonstrated in spleens from patients with Hodgkins disease, either with or without invasion of the organ by tumor (1). Interest in this laboratory has centered recently on cytochemical localization of immunoglobulins by means of an immunoglobulin-peroxidase bridge procedure (2) and a satisfactory method has been developed for selectively visualizing immunocytes with this technique. As a means of assessing the basis for increased IgG biosynthesis in spleens of Hodgkin patients, this immunostaining procedure has been applied to localization of IgG-producing cells in specimens with Hodgkins disease ...

Kandukuri Mahesh Kumar1, V. Indira2, Sudhir Kumar Vujhini3 1Assistant Professor, 2Prof & HOD, 3Associate Professor, Department of Pathology, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad.. Abstract Of all the pediatric malignancies, lymphomas account for about 10-15% of the cases with half of them diagnosed as Hodgkins lymphoma. Remarkably, this malignancy has a high cure rate with a 5-year survival rate approaching 95%. Hodgkins lymphoma has an overall incidence rate of 14 per 100,000 less than 15 years of age. It has a typical bimodal distribution with respect to age. In developed countries, the peak incidence is seen in young adults and the elderly. While, in developing countries the incidence is higher among children and young adults with a male preponderance. Histologically, mixed cellularity subtype of classical Hodgkins lymphoma occurs commonly in the children and in developing countries. We report three typical cases of classical Hodgkins lymphoma, mixed cellularity ...

Leo Gordon, MD:We have a 52-year-old woman, a longtime smoker, who presented with abdominal pain. Evaluation on physical exam revealed right cervical adenopathy, and a CT [computed tomography] scan, which was done to evaluate the abdominal pain, revealed mediastinal adenopathy and abdominal adenopathy. A PET [positron emission tomography] scan confirmed those findings. She was found, therefore, to have clinical stage IIIa disease. A biopsy of the right cervical node revealed nodular sclerosis, Hodgkin lymphoma, which is classical Hodgkin lymphoma. At the end of staging, she had stage IIIa disease. She had no b symptoms: no weight loss, no fever, and no night sweats. She had a long history of smoking but no significant cardiac disease and no significant pulmonary disease.. She was treated with combination of Adriamycin [doxorubicin], brentuximab vedotin, Velban [vinblastine], and DTIC [dacarbazine], or the ABVVD chemotherapy regimen, as outlined in the recently published ECHELON trial comparing ...

Looking for non-Hodgkin's lymphoma? Find out information about non-Hodgkin's lymphoma. any cancer of the lymphoid tissue in which the Reed-Sternberg cells characteristic of Hodgkins disease Hodgkins disease, a type of cancer of the lymphatic... Explanation of non-Hodgkin's lymphoma

Hodgkin Lymphoma, also known as Hodgkin’s Disease, is tumor in the lymph glands or tissues and organs with lymphatic tissue, for instance the spleen. The presence of the Reed-Sternberg cell signifies that the immune system is compromised already with cancer. This disease affects two waves of people, one wave is composed of ages 15 to 35 years old and recently a second wave for those over 55 years old.. The symptoms of Hodgkins Lymphoma are as follows, swelling in the neck, usually on one side. This is because of the nodes on the neck and shoulders are often affected. Another is the glands in the armpits and groin are swollen. Constant fever, night sweats, and excessive tiredness. Further more, the symptoms also include loss of appetite, stomach pain, anemia and weight loss. People with this illness may survive without treatment for years however undergoing treatment will help cure the disease.. The causes of Hodgkins Lymphoma remain mysterious; however, researchers formed a list of risk ...

Although 1964 heralded the discovery of the Epstein-Barr virus (EBV) in the biopsies of patients with Burkitt lymphoma (BL), it was some 21 years later before the virus would be identified in the...

Tumors of the hematopoietic and lymphoid tissues or haematopoietic and lymphoid malignancies are tumors that affect the blood, bone marrow, lymph, and lymphatic system. As those elements are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. ...

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Hodgkin lymphoma is a cancer of the lymph system and is diagnosed by the identification of a characteristic cell under the microscope (the Reed- Sternberg cell). Hodgkins lymphoma typically begins in the lymph nodes in one region of the body and then spreads through the lymph system in a predictable manner. It may spread outside the lymph system to other organs such as the lungs, liver, bone and bone marrow.. In order to understand the best treatment options available for Hodgkins lymphoma, it is important to first determine where the cancer has spread in the body. All new treatment information is categorized and discussed by the stage, or extent, of the disease. Determining the extent of the spread or the stage of the cancer requires a number of procedures including CT scans, PET scans and blood tests. The goal of staging Hodgkin lymphoma is to determine which patients have early and which have advanced stage cancer. Historically, many patients required surgical staging and removal of the ...

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On October 14, 2020, the Food and Drug Administration extended the approval of pembrolizumab (KEYTRUDA®, Merck Sharp & Dohme Corp.) for the following

Hodgkins lymphoma, also known as Hodgkins disease, is a cancer of lymph tissue found in the lymph nodes, spleen, liver, bone marrow, and other sites. Hodgkins Lymphoma is characterized by the presence of a special type of lymphatic cell called a Reed-Sternberg (RS) cell. These cells are giant lymphocytes derived from B-cells. Because they are…

Clinical study. We conducted a phase I study (NCT01316146) designed to assess the feasibility and safety of infusing escalating doses of autologous, polyclonally activated, peripheral blood T cells that were genetically modified to express a CD30-specific CAR (CD30.CAR) (31) encoding the CD28 endodomain in patients with relapsed/refractory CD30+ lymphoproliferative disorders (HL and non-Hodgkin lymphoma). All patients with a diagnosis of HL had CD30 positivity determined by a pathologist according to her/his institutional hematopathology standard measured against positive and negative controls. In all those cases, the Reed-Sternberg cells were deemed CD30+ and CD15+ (in a membrane/Golgi pattern, when described). Patient 2 (ALK- ALCL) had malignant cells that were also reported by a pathologist to be positive for CD30, CD4, and epithelial membrane antigen (EMA). Patient 9 (ALK+ ALCL), who had the best response, had malignant cells that were described as having strong membranous and cytoplasmic ...

This randomized phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma.

BACKGROUND: The survival of patients with Hodgkin disease (HD) varies markedly across Europe and generally is shorter than the survival of patients in the U.S. To investigate these differences, the authors compared population-based HD survival in relation to morphologic type among populations in Europe and the U.S. METHODS: The authors analyzed 6726 patients from 37 cancer registries that participated in EUROCARE-3 and 3442 patients from 9 U.S. Surveillance, Epidemiology, and End Results (SEER) registries. Patients were diagnosed during 1990 to 1994 and were followed for at least 5 years. The European registries were grouped into EUROCARE West, EUROCARE UK, and EUROCARE East. Morphologic groups were nodular sclerosis, mixed cellularity, lymphocyte depletion, lymphocyte predominance, and not otherwise specified (NOS). The influence of morphology on geographic differences in 5-year relative survival was explored by using multiple regression analysis. RESULTS: In the model that was adjusted by age, ...

Bridgewood CD, Stacey M, Alase A, Lagos D, Graham A, Wittmann M.(2016) IL-36 has pro-inflammatory effects on human endothelial cells. Experimental Dermatology Sep 27. doi: 10.1111/exd.13228. [Epub ahead of print. Sultan S, Liu W, Peng YH, Roberts W, Whitelaw D, Graham AM (2015) The role of maternal gestational diabetes in inducing fetal endothelial dysfunction Journal of Cellular Physiology 230, 2695-2705. Fhu CW, Graham AM, Yap CT, Al-Salam S, Castella A, Chong SM, Lim YC (2014) Reed Sternberg cell-derived lymphotoxin-α activates endothelial cells to enhance T cell recruitment in classical Hodgkin lymphoma. Blood. 2014 Aug 19. pii: blood-2014-05-576140. Banga NR, Prasad KR, Homer-Vanniasinkam S, Graham A (2012) An in vitro model of warm hypoxia-repoxygenation injury in human liver endothelial cells J Surg Res Epub PMID: 22472696. Alkhoury K, Homer Vanniasinkam S, Parkin SM, Graham AM (2011) Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates ...

Hodgkins disease. Light micrograph of a section through a lymph node affected by lymphocyte-predominant pattern Hodgkins disease. Hodgkins disease, or Hodgkins lymphoma, is a malignant (cancerous) tumour (neoplasm) that develops in the lymphoreticular system. There are four histological forms of the disease each with a different prognosis and level of aggression. In this form lymphocytes make up the bulk of tissue in affected nodes and relatively few Reed-Sternberg (popcorn) cells are present. It is associated with the best prognosis if diagnosed at an early stage. - Stock Image C003/6191

Hodgkin lymphoma is a rare cancer arising from white blood cells. People infected with HIV or Epstein-Barr virus, which causes mononucleosis, have a higher risk of developing Hodgkin lymphoma. Most Hodgkin patients can be cured by treatment with radiation, chemotherapy, or both. Wikipedia SNPs implicated in susceptibility to Hodgkin lymphoma: ...

TY - JOUR. T1 - Hodgkins disease in children. Pathologic study of 87 cases. AU - Carbone, A.. PY - 1979. Y1 - 1979. N2 - From 1963 to 1977 at the Instituto Nazionale Tumori at Milan, 112 patients below the age of 16 years with Hodgkins disease (HD) were observed, representing 13.2% of all the cases of this disease seen during this period. 87 of these cases are the subject of the present study. 59 patients were males and 28 females (2.1:1 ratio). The age range varied from 2 years 10 months to 15 years 10 months (median 10 years). 43 (49.4%) children, of whom 35 were males and 8 females, were below the age of 10 years at the onset of their disease. The clinical staging resulted in 34 patients as stage I, 33 as stage II, 13 as stage III and 7 as stage IV. The histologic type was nodular sclerosis (NS) in 49 cases (56.3%), lymphocytic predominance (LP) in 15 cases (17.2%), mixed cellularity (MC) type in 9 cases (10.3%) and lymphocytic depletion (LD) in 8 cases (9.2%). In the remaining 6 cases the ...

Chemotherapy in Hodgkin lymphoma (Hodgkin disease) (costs for program #234101) ✔ University Hospital Ulm ✔ Department of Hematology, Oncology, Rheumatology ✔ BookingHealth.com