The Expression of Vasoactive Intestinal Peptide Receptor 1 Is Negatively Modulated by MicroRNA 525-5p. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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Parasite growth inside the erythrocyte causes dramatic alterations of host cell which similarly facilitates nutritional vitamins acquisition from extracellular environment and in other hand plays a part in the symptoms of serious malaria. for the bloodstream food and injects the sporozoites in to the dermis. Sporozoites after that migrate towards the liver organ infect hepatocytes and stay in a medically silent stage. Between 5 to 16 times later with regards to the types sporozoite undergoes an activity of asexual replication launching a large number of merozoites per contaminated hepatocytes in to the bloodstream. Some sporozoites are predestined to build up into non-dividing hepatocytic forms (hypnozoites) that may stay latent in the liver organ for a few months to years until they activate and trigger relapse attacks. Once in the blood stream each merozoite after that invades an erythrocyte and resides within a self-created membrane-bound vacuole and goes through recurring rounds of ...
The aim of this study was to construct a plasmid expressing glycoprotein IIb-IIIa (GPIIb/IIIa) and D-dimer single-chain bispecific antibody for the targeted therapy of thrombosis. of drug with high avidity […]. ...
VIPR1 - VIPR1 (untagged)-Human vasoactive intestinal peptide receptor 1 (VIPR1) available for purchase from OriGene - Your Gene Company.
Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene. VIPR2 is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus. VIPR2 is also expressed in the cerebellum. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP (VIRP 1 and 2) and PACAP (ADCYAP1R1) share homology, they differ in their substrate specificities and expression patterns. VIPR2 transduction results in upregulation of adenylate cyclase activity. Furthermore, VIPR2 mediates the anti-inflammatory effects of VIP. Research using VPAC2 knockout mice implicate it in the function of the circadian clock, growth, basal energy expenditure and male reproduction. VIPR2 and/or PAC1 receptor activation is involved in cutaneous ...
Schizophrenia patients often show irregularities in sleep and circadian rhythms and deficits in recognition memory. Similar phenotypes are seen in schizophrenia-relevant genetic mouse models, such as synaptosomal associated protein of 25 kDa (Snap-25) point mutant mice, vasoactive intestinal peptide receptor 2 (Vipr2) knockout mice, and neuregulin 1 (Nrg1)-deficient mice. Sleep and circadian abnormalities and impaired recognition memory may be causally related in both schizophrenia patients and schizophrenia-relevant mouse models, since sleep deprivation, abnormal photic input, and the manipulation of core clock genes (cryptochrome 1/2) can all disrupt object recognition memory in rodent models. The recognition deficits observed in patients and mouse models (both schizophrenia-related and -unrelated) are discussed here in terms of the dual-process theory of recognition, which postulates that there are two recognition mechanisms-recollection versus familiarity-that can be selectively impaired by brain
Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large (,500-kilobase) CNVs at several loci, including microdeletions at 1q21.1 (ref. 2), 3q29 (ref. 3), 15q13.3 (ref. 2) and 22q11.2 (ref. 4) and microduplication at 16p11.2 (ref. 5). However, these CNVs collectively account for a small fraction (2-4%) of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 (0.35%) patients versus 2 of 7,431 (0.03%) controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. ...
Interval of hypoxic air flow (for hypoxia groups) is indicated by dashed line, time of drug inhalation (t = min) by arrow. Lines connecting individual facts
Breast cancer vasoactive intestinal peptide (VIP) receptors were characterized. Using in vitro autoradiographic techniques, 125I-labeled VIP bound with high affinity to breast biopsy sections. 125I-labeled VIP bound specifically to five breast cancer cell lines examined using receptor-binding techniques. Specific 125I-labeled VIP binding to MDA-MB-231 cells was inhibited with high affinity by VIP and pituitary adenylate cyclase-activating polypeptide (ICb50 = 2 nm) and with moderate affinity by the VIP hybrid (IC50 = 0.5 µm) VIP elevated the cAMP in a dose-dependent manner, and VIP hybrid (10 µm) inhibited the increase in cAMP caused by VIP. Using Northern blot analysis, VIP (10 nm) stimulated c-fos and c-myc mRNA, and the increase caused by VIP was reversed by the VIP hybrid. The VIP hybrid inhibited breast cancer growth in vitro and in vivo using nude mice bearing breast cancer xenografts. These data suggest that the VIP hybrid is a breast cancer VIP receptor antagonist.. ...
To identify the molecular components of the vasoactive intestinal peptide (VIP) binding sites in the liver, 125I-labelled VIP was covalently linked to liver membranes by using the cleavable cross-linker dithiobis(succinimidylpropionate). Purified rat liver plasma membranes were incubated with 125I-VIP, washed and treated with 1 mM-cross-linker. Polyacrylamide-gel electrophoresis of membrane proteins followed by autoradiography revealed a major 125I-VIP-protein complex of Mr 51 000. A minor Mr 89 000 complex was also observed. An identical pattern of protein labelling was obtained using crude membranes from rat liver. Labelling of the Mr 51 000 and 89 000 species was specific in that it could be abolished by native VIP, but was unaffected by 1 microM-glucagon and cholecystokinin octapeptide. Densitometric scanning of autoradiographs indicated that the labelling of the two species was abolished by similar low VIP concentrations (0.1-100 nM). It was also reduced by two VIP agonists, peptide ...
Purpose: : Studies from our laboratory have demonstrated that vasoactive intestinal peptide (VIP) directly converts the normally susceptible C57/BL/6 (B6) mouse to resistant after P. aeruginosa induced keratitis. Previously we have shown that VIP regulates cytokine/chemokine production, host inflammatory cell function and extracellular matrix and adhesion molecules expression. This study tested the hypothesis that VIP also regulates Toll-like receptors (TLRs) and TLR-related molecules, modulating the inflammatory response and promoting corneal healing and resistance. Methods: : B6 mice were injected i.p. with recombinant (r) VIP daily from -1 through 7 days p.i. Control mice were similarly injected with PBS. In vitro stimulation assays also were performed using A6(1) cells to test the effects of VIP on corneal epithelial cells specifically. Real-time RT-PCR was used to assess rVIP treatment in the regulation of TLR and TLR-related molecule expression both in vivo and in vitro. Results: : ...
Signaling pathways that activate CREB may inhibit the potency of T cell responses following stimulation. One of the major mechanisms by which this occurs is the sequestration of CBP, which is also an NF-κB binding partner. One of the major molecules that signals through this pathway is vasoactive intestinal peptide (VIP). VIP is a 28 amino acid peptide that is secreted throughout the body by a variety of cell types including immune cells. VIP has shown to be a potent anti-inflammatory molecule with pleiotropic effects on T cells including cell cycle arrest and inhibition of cytokine secretion. The VIP signaling pathway represents a therapeutic target in disease settings in which a more robust T cell response would be beneficial. Acute myeloid leukemia (AML) is a hematological malignancy that has been explored as a candidate for a variety of T cell-based immunotherapies due to weak CD8 responses to AML blasts. We demonstrate here that administration of a hybrid peptide antagonist that blocks VIP ...
TARGETED FUSION PROTEINS FOR CANCER THERAPY - The invention relates to fusion proteins useful as therapeutics against cancer. The fusion protein comprises of cell-targeting moiety and apoptosis-inducing moiety. Cell-targeting moiety and apoptosis-inducing moiety are linked by a flexible linker, which are specifically recognized by cancer specific protease and cleaved in situ to release the apoptotic domain. In particular, the invention is illustrated by a recombinant fusion protein between human Vasoactive Intestinal Peptide (VIP) and BH3 domain of Bcl2 family protein, linked by a linker that has site for cancer specific proteases. The fusion protein specifically targets VIP receptor over-expressing cancer cells and induces cell-specific apoptosis after cleavage at the linker site by cancer specific proteases. Such fusion proteins are useful for the delivery of therapeutic/apoptotic moiety (peptides) to specific cells with perturbed expression of, but not limited to neuropeptide receptors ...
Published in: Annals of the New York Academy of Sciences, vol. 527, num. Vasoactive Intestinal Peptide and Related Peptides, p. 110-129 ...
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vasoactive intestinal peptide (Science: gastroenterology, protein) peptide of 28 amino acids, originally isolated from porcine intestine, but later found in the central nervous system where it acts as a neuropeptide and is released by specific interneurons. May also affect behaviour of cells of the immune system. ...
Vasoactive intestinal peptide (VIP) is a neuroendocrine peptide that has been implicated in a myriad of functions. VIP promotes neuronal survival during development and apoptotic challenges. Further, VIP has been shown to regulate hormonal release, circadian rhythms, vasodilation, and T cell proliferation in central and peripheral tissues. VIP binds with equally high affinity to VPAC1 and VPAC2 receptors, members of the Class B family of G protein-coupled receptors (GPCRs) that also include the PAC1, glucagon (GCGR), and CRH receptors. VIP binding has previously been shown to increase downstream MAPK signaling cascades, especially MEK/ERK. Given the structural similarities and functional overlap between VPAC1 and VPAC2 receptors, we sought to investigate whether there are small molecule modulators that can probe and identify the functional distinctions between the two receptor subtypes. For these studies, we used HEK-293 cells stably expressing the VPAC1-EGFP or the VPAC2-EGFP receptor. The cultures
VIP - VIP (untagged)-Human vasoactive intestinal peptide (VIP), transcript variant 1 available for purchase from OriGene - Your Gene Company.
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FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011 ...
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Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions ...
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The thinking of the older toddler is definitely more advanced than that of the infant or adolescent toddler, who views the set as a series of objects. Such interactions can reflect the adeptness of a toxicant to aid a metabolic pathway that is involved in the bioacti- vation of the co-administered toxicant, thereby resulting in greater cubicle mistreatment before the toxic metabolite. Am Rev Respir Orcus 1987;135:86974 van de Garde EM, Hak E, Souverein PC, et al viagra 75mg free shipping impotence etymology. In vivo punch of chronic management of vasoactive intestinal peptide on gut-associated lymphoid tissues in rats. In the future, to perceive deleterious effects on gamete forming, test chemicals are repeatedly administered to mans and female animals with a view between 2 and 6 weeks in duration last to mating. alone the reference outgo of medically treating low is galactic discount penegra 100 mg visa androgen hormone 3 ep. They may occurrence more infections during the premier 1 to 2 years ...
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1969年8月9日出生,安徽省怀宁县人。肿瘤学博士,主任医师,博士生导师,中山大学肿瘤防治中心综合科科室副主任。主要从事肿瘤综合治疗;肠癌、肺癌、乳腺癌等常见肿瘤的内科治疗(尤其是靶向治疗);VIP病人保健和管理。至今发表科研论文105篇,其中第一作者/通讯作者54篇(包括14篇SCI论文),主持12项科研基金,包括3项国家自然科学基金。 另外,承担...
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Yassar Mugerwa is a Ugandan professional footballer, who plays as a Midfielder for Orlando Pirates in the Premier Soccer League. In January 2014, coach Milutin Sedrojevic, invited him to be a part of the Uganda national football team squad for the 2014 African Nations Championship. The team placed third in the group stage of the competition after beating Burkina Faso, drawing with Zimbabwe and losing to Morocco. "Micho Names Uganda Final Team For CHAN 2014". kawowo.com. Retrieved 11 February 2014. "Uganda Cranes Regroup For CHAN 2014 Preparations". kawowo.com. Retrieved 11 February 2014. "Uganda makes changes in squad for 2014 Africa Nations Championship". xinhuanet.com. Retrieved 11 February 2014. "Ugandas impressive CHAN start". espnfc.com. Retrieved 11 February 2014. "Zimbabwe vs Uganda Preview". goal.com/. Retrieved 11 February 2014 ...
Looking for online definition of Vasoactive intestinal peptide in the Medical Dictionary? Vasoactive intestinal peptide explanation free. What is Vasoactive intestinal peptide? Meaning of Vasoactive intestinal peptide medical term. What does Vasoactive intestinal peptide mean?
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life, difficult clinical management and high costs to the health care system. To date there is no proven pathomechanism to satisfactorily explain this disorder. Studies have identified abnormalities in immune function but these data are inconsistent. We investigated the profile of markers of immune function (including novel markers) in CFS/ME patients. We included 95 CFS/ME patients and 50 healthy controls. All participants were assessed on natural killer (NK) and CD8+T cell cytotoxic activities, Th1 and Th2 cytokine profile of CD4+T cells, expression of vasoactive intestinal peptide receptor 2 (VPACR2), levels of NK phenotypes (CD56bright and CD56dim) and regulatory T cells expressing FoxP3 transcription factor. Compared to healthy individuals, CFS/ME patients displayed significant increases in IL
Purpose : Numerous studies have demonstrated the essential roles of the peripheral nervous system as the neuroendocrine system, mediating the secretion of neuropeptides and/or neurotransmitters to suppress the excessive inflammatory reactions in autoimmune diseases, such as inflammatory bowel disease. We recently reported that loss of corneal nerve leads to corneal inflammation and the loss of neurogenic immune privilege. The purpose of this study was to evaluate the effect of vasoactive intestinal peptide (VIP) on innate immunity in denervated cornea. Methods : Trigeminal axotomy (TA) or sham procedure were performed in 6-8 week-old male BALB/c mice. Corneal opacity grading, immunohistochemistry (IHC) and corneal cytokine levels were determined 24 hours after 20μg of LPS instillation onto the cornea with or without TA and topical VIP treatment (more than N=3). Corneal opacity grading was as follows; grade 0: clear, grade 1: mild opacity, grade 2: moderate opacity, grade 3: severely dense ...
VIP and PACAP are potent immunosuppressive agents that affect both innate and adaptive immunity (14, 15, 16). Until now, the mechanisms described for their immunosuppressive activity included macrophage/dendritic cell/microglia deactivation, and support for Th2 effector differentiation and survival. In this study, we report on the induction of Treg through the VIP/PACAP generation of tolerogenic DCs.. We reported previously that VIP/PACAP have different effects on immature and LPS-matured DCs (17). The VIP/PACAP treatment of immature DCs led to the up-regulation of CD86, and increased capacity to stimulate CD4 T cells and promote Th2-type responses. In contrast, the VIP/PACAP treatment of LPS-matured DCs prevented the expression of CD80 and CD86, reduced the stimulatory activity for CD4 T cell proliferation and cytokine production, and differentially affecting Th1- and Th-2 chemoattractants (23, 24). These results support the previously reported effect of VIP/PACAP on the immune response, i.e., ...
VPAC1 is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.[1] VIP acts in an autocrine fashion via VPAC11 to inhibit megakaryocyte proliferation and induce proplatelet formation.[5][6] ...
Scientists are eyeing a rare genetic glitch for clues to improved treatments for some people with schizophrenia - even though they found the mutation in only one third of 1 percent of patients.. In the study, funded in part by the National Institutes of Health, schizophrenia patients were 14 times more likely than controls to harbor multiple copies of a gene on Chromosome 7. The mutations were in the gene for VIPR2, the receptor for vasoactive intestinal peptide (VIP) - a chemical messenger known to play a role in brain development. An examination of patients blood confirmed that they had overactive VIP activity.. Discovery of the same genetic abnormality in even a small group of patients buoys hopes for progress in a field humbled by daunting complexity in recent years. The researchers previous studies had suggested that the brain disorder that affects about 1 percent of adults might, in many cases, be rooted in different genetic causes in each affected individual, complicating prospects for ...
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008] ...
Dufès C, Gaillard F, Uchegbu IF, Schätzlein AG, Olivier J-C, Muller J-M. 2004. Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain.. Int J Pharm. 285(1-2):77-85. ...
what is the Full Form of VIPR, V.I.P.R. full form. Definition, long form , meaning and full name of VIPR. Find all acronyms and expansion of these 4 letters.
Poznata su dva receptora za vazoaktivni intestinalni peptid (VIP): VPAC1 i VPAC2.[1][2] Za ove receptore se vezuje VIP i u izvesnoj meri hipofizni adenilat ciklazno aktivirajući peptid (PACAP). Oba receptora su članovi 7 transmembranske familije G protein spregnutih receptora.. VPAC1 je široko zastupljen u centralnom nervnom sistemu, jetri, plućima, crevima i T-limfocitima.. VPAC2 je prisutan u centralnom nervnom sistemu, pankreasu, skeletalnim mišićima, srcu, bubrezima, masnom tkivu, testisima, i želucu.. ...
The localization of the messenger RNA (mRNA) encoding vasocative intestinal peptide/peptide histidine isoleucine (VIP/PHI) in the rat eye was studied by in situ hybridization histochemistry using a...
The SCN coordinates daily timekeeping in the body and VIP plays a key role in communication between individual brain cells within this region. At a cellular level, the SCN expresses different electrical activity in circadian time. Higher activity is observed during the day, while during night there is lower activity. This rhythm is thought to be important feature of SCN to synchronize with each other and control rhythmicity in other regions.[18]. VIP acts as a major synchronizing agent among SCN neurons and plays a role in synchronizing the SCN with light cues. The high concentration of VIP and VIP receptor containing neurons are primarily found in the ventrolateral aspect of the SCN, which is also located above the optic chiasm. The neurons in this area receive retinal information from the retinohypothalamic tract and then relay the environmental information to the SCN.[11] Further, VIP is also involved in synchronizing the timing of SCN function with the environmental light-dark cycle. ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Sigma-Aldrich offers abstracts and full-text articles by [T W Moody, F Zia, M Draoui, D E Brenneman, M Fridkin, A Davidson, I Gozes].
The views presented here are those of the author and are not to be construed as official or reflecting the views of the Uniformed Services University of the Health Sciences, the Department of Defense or the U.S. Government ...
Supplementary Materialsjcm-09-01035-s001. The very best positioned genes within cluster 4, which demonstrated the most severe prognosis, acted Quizartinib manufacturer as paraneoplastic genes mainly, as the genes within cluster 6 acted as anti-tumor Rabbit polyclonal to ABCC10 genes mainly. A big change was found about the suggest age in the various clusters. No significant relationship was found between your tumor staging and the various clusters. To conclude, our result supplied a proof-of-principle for the lifetime of phenotypic variety among the epigenetic clusters of OSCC and confirmed the electricity of the utilization epigenetics modifications in devolving brand-new prognostic and therapeutics equipment for OSCC sufferers. = 159). With regards to epigenetic alterations analysis, we classified the samples into consensus clusters, to determine differentially expressed marker genes for each subtype, this way we were able to define the patients into several subgroups, based on genes ...