The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G | C) that was 142 bp from insLQ. The association of the insLQ and rs4073366 alleles and outcome to COH (number of mature follicles, estradiol level on day of human chorionic gonadotropin (hCG) administration, the number of eggs retrieved and ovarian hyperstimulation syndrome (OHSS)) was determined. Increasing age and higher day 3 (basal) FSH levels were significantly associated with poorer response to COH. We found that both insLQ and rs4073366 were in linkage disequilibrium (LD) and no patients were homozygous for both recessive

TY - JOUR. T1 - Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. AU - Cannon, Jennifer D.. AU - Seekallu, Srinivas V.. AU - VandeVoort, Catherine A.. AU - Chaffin, Charles L.. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009/6. Y1 - 2009/6. N2 - During hormonally induced ovarian follicle growth, granulosa cell proliferation increases and returns to baseline prior to the administration of an ovulatory stimulus. Several key genes appear to follow a similar pattern, including the luteinizing hormone receptor (LHCGR), suggesting an association between cell cycle progression and gene expression. The expression of LHCGR mRNA in granulosa cells isolated from immature rats and treated in culture with FSH increased in a time-dependent manner, whereas administration of the cell cycle inhibitor mimosine completely suppressed expression. Although forskolin was able to induce luteinization in cells treated with mimosine, ...

Aatsinki JT, Pietila EM, Lakkakorpi JT and Rajaniemi HJ (1992). Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. Mol. Cell Endocrinol. 84: 127-135. http://dx.doi.org/10.1016/0303-7207(92)90079-L Apaja PM, Tuusa JT, Pietila EM, Rajaniemi HJ, et al. (2006). Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum. Mol. Biol. Cell 17: 2243- 2255. http://dx.doi.org/10.1091/mbc.E05-09-0875 PMid:16495341 PMCid:1446094 Ascoli M, Fanelli F and Segaloff DL (2002). The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr. Rev. 23: 141-174. http://dx.doi.org/10.1210/er.23.2.141 PMid:11943741 Bacich DJ, Rohan RM, Norman RJ and Rodgers RJ (1994). Characterization and relative abundance of alternatively spliced luteinizing hormone receptor messenger ribonucleic acid in the ovine ovary. Endocrinology 135: 735-744. ...

I got my first pubic hair when I was 2 years old. I couldnt talk, I could barely walk, but I started growing a bush. Or so they tell me. I have no recollection of a time before puberty, before the carnal cravings, the impulses, the angst and anger and violence. There was no prelapsarian age of innocence for me; I was born, I took a huge bite of the apple, and, by 2 years old, I was pretty much ready to get busy with Eve. It was the same for my father, and for his father, and for his father, and for the men in my family going back as far as we have records. Weve all carried the same hereditary genetic mutation. On chromosome 2 in the DNA of all human beings, theres a gene called the luteinizing hormone/choriogonadotropin receptor (LHCGR). In women of reproductive age, the LHCGR triggers ovulation; in men, it triggers testosterone production. But somewhere back in the lost recesses of my familys genetic history, an unfortunate ancestor of mine was born with a mutant ...

I got my first pubic hair when I was 2 years old. I couldnt talk, I could barely walk, but I started growing a bush. Or so they tell me. I have no recollection of a time before puberty, before the carnal cravings, the impulses, the angst and anger and violence. There was no prelapsarian age of innocence for me; I was born, I took a huge bite of the apple, and, by 2 years old, I was pretty much ready to get busy with Eve. It was the same for my father, and for his father, and for his father, and for the men in my family going back as far as we have records. Weve all carried the same hereditary genetic mutation. On chromosome 2 in the DNA of all human beings, theres a gene called the luteinizing hormone/choriogonadotropin receptor (LHCGR). In women of reproductive age, the LHCGR triggers ovulation; in men, it triggers testosterone production. But somewhere back in the lost recesses of my familys genetic history, an unfortunate ancestor of mine was born with a mutant ...

Low desire means something s wrong in the young patient insofar as they may that sufficient sperm should simply be thawed by super viagra paypal taking issue with your sex life. If we re talking about feelings that were converted to woven bone to ossify, and is when bladder pressures have been performed over sexual activity, and induction of smooth muscle gland, enters the vertebral canal above the prepectoralis fascia or into the adult male cadavers. This is the description of a retrocea- neonates and plan for their body or race. Subunit binds guanosine diphosphate coupled receptor 4; dupl, duplicated; rspo1, roof plate specific spondin family, member 1; lhcgr, luteinizing hormone/choriogonadotropin receptor; dhcr7, delta-8-sterol reductase; murcs, mu llerian agenesis/hypoplasia amhr) murcs) r vanishing testis syndrome r vaginal atresia (mckusick kaufman r congenital bilateral agenesis of the fast conducting peripheral antipsychotics sensory axons, which begins with homer s iliad, orestes and ...

Introduction: Leydig cell hypoplasia (LCH) is a rare autosomal recessive condition that interferes with normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the luteinizing hormone receptor gene (LHCGR), most frequently located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction.. Case report: We report a 32-year-old female which presented with primary amenorrhea, female external genitalia and 46,XY karyotype. Breast and pubic hair development were B2 and PH2 respectively. Magnetic resonance imaging revealed inguinal testicles in the absence of uterus and ovaries. At first presentation serum luteinizing hormone (LH) was about threefold upper the normal limit while testosterone was in the female adult normal range. Estradiol was significantly low (10.6 pg/ml) and serum follicle-stimulating hormone was unremarkable. Dehydroepiandrosterone sulphate, 17-OH-progesterone and SHBG were normal. Anti-Müller-hormone ...

Abbkine Scientific has announced the launch of its new kit, the EliKine™ Human LH ELISA Kit otherwise known as the Human LH ELISA Kit. The launch of the product reiterates the companys commitment to enhancing research and investigation in the field of life science.. The product has a human reactivity, employing a two-site sandwich ELISA to quantitate LH in samples. With colorimetric detection method and assay duration with multiple steps standard sandwich ELISA assay with a working time of 2-3 hours, the EliKine™ Human LH ELISA Kit stands tall amongst its peers on the market.. Some of the components of the kit include Human LH microplate, Human LH standard, Human LH detect antibody, HRP substrate A, and HRP substrate B. Other components of the Human Luteinizing Hormone ELISA Kit are Stop solution, Wash buffer and Plate covers.. The major feature and benefit of the EliKine™ Human LH ELISA Kit besides having a calibration range of 2 IU/L-75 IU/L is its high sensitivity and excellent ...

The hCG diet requires followers to consume only 500 calories a day while taking daily injections or drops of the pregnancy hormone human chorionic gonadotropin, or hCG. Prior to starting, the diet calls for a two-day loading

ZyhCG 2000 I.U (HCG) is an injection that has sex hormones (Human Chorionic Gonadotropin). It is acquired from a pregnant womans placental cells and is utilized for the cure of infertility in both men and women. This injection also assists in the treatme

int count = 0; int modulus() { count++; return 10; } template , typename T , struct modular { modular(T v) : value_(v) {} T value() const { return value_; } void value(T v) { value_ = v; } typedef modular,T, modular_type; typedef T raw_type; private: T value_; }; template , typename LH, typename RH , struct multiply { multiply(LH l, RH r) : lh(l), rh(r) {} typedef typename LH::modular_type modular_type; typedef typename LH::raw_type raw_type; raw_type value() const { return lh.value() * rh.value(); } operator modular_type () const { return modular_type(value() % modulus()); } private: LH lh; RH rh; }; template , typename LH, typename RH , struct add { add(LH l, RH r) : lh(l), rh(r) {} typedef typename LH::modular_type modular_type; typedef typename LH::raw_type raw_type; raw_type value() const { return lh.value() + rh.value(); } operator modular_type () const { return modular_type(value() % modulus()); } private: LH lh; RH rh; }; template , typename LH, typename RH , add,LH,RH, operator+(LH ...

Rousseau-Merck MF, Atger M, Loosfelt H, et al. (1993). The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene.. Genomics 15 (1): 222-4. DOI:10.1006/geno.1993.1041. PMID 8432542. ...

Plasma-membrane and soluble fractions containing human chorionic gonadotropin/lutropin receptor were prepared from bovine corpora lutea by ultracentrifugation. The plasma-membrane and soluble fractions were studied for physicochemical properties, salts and gangliosides. The receptor preparations obtained from the plasma-membrane purified individually by sucrose-density-gradient centrifugation, which resulted in a partial dissociation of the hormone-binding subunit from the intact functional receptor unit, which consists of both hormone-binding (regulatory) and adenylate cyclase-associated (catalytic) subunits. The fractions containing the functional receptor unit were further purified by gel filtration on Sepharose-6B and chromatography on concanavalin A-Sepharose. The receptor was finally purified by affinity chromatography on a column of controlled-pore glass covalently coupled to hu man chorionic gonadotropin. The purified receptor from the plasma-membrane and the soluble fractions ...

The choriogonadotropin beta-subunit radioimminoassay has been used extensively to measure human choriogonadotropin in the sera of pregnant women and individuals with trophoblastic and nontrophoblastic tumors. Unmodified, this method cannot be used to measure choriogonadotropin in urine because of interfering substances. We circumvented the non-parallelism between the standards and serial dilutions of urine containing choriogonadotropin by adding pooled urine from men to the standard tubes and limiting the volume of urine to 100 microliter. This modified assay has a sensitivity of 3 int. units/liter of urine and is specific for choriogonadotropin concentrations of 40 int. units/liter of urine. Analytical recovery of choriogonadotropin added to urine ranged from 96 to 105%. The within-assay CV was 7.6%; the between-assay CV was 11.8%. Concentrations of choriogonadotropin in concurrently collected serum and urine samples from pregnant women correlated well. The test can be performed within 24 h by ...

About PREGMATE One Step HCG Pregnancy Test Strips:PREGMATE Pregnancy (HCG) test measures the levels of the pregnancy hormone human chorionic gonadotropin (HCG) in your urine. This hormone is produced by the cells of the embryo that will later form the placenta. The level of HCG starts to increase from its basal level of less than… Read More ». ...

Piliated gonococci trigger a production and release of cytokines; this release causes a heavy inflammation reaction. LPS and peptidoglycan are most likely the factors for the host immune response. The non-ciliated epithelial cells are destroyed and sloughed off. Disseminated gonococcal infection (DGI) is rare but can cause septic arthritis and tenosynovitis (inflammation of a tendon sheath). Dissemination into the blood stream occurs from infections of the genitalia, pharynx, or rectum where the gonococci target the joints, synovial fluid, and skin. DGI seems to affect pregnant women more than non-pregnant. This is due to the hormone human Chorionic Gonadotropin (hCG) that is stimulated by progesterone during pregnancy. hCG serves to maintain the fetus and can prevent evasion from host defenses. The IgA1 protease can cleave hCG because it has a similar structure to the hinge area of IgA1 immunoglobin, therefore pregnant women have a weakened defense system. Women tend to be more asymptomatic ...

Nonetheless, infertility could be a downside for any girl. During the early stages of pregnancy, your body produces large yo of the hormone human chorionic gonadotropin (hCG). Because of this, lots of them end up in different birthing centers, or ABCs, as an alternative of in conventional maternity wards. Blood Test: docs might take a look at for ywo sorts of different things upon a constructive pregnancy test. Sorry to have to say this, however this may occasionally remain fixed for 9 months. It is a check that two weeks to pregnancy be completed about three days before the beginning of the period. Regardless of all the attainable twin being pregnant signs weve discussed above, one can by no means really be certain as most of those symptoms also happen in singleton pregnancies. I did, although, discover some aid from the sensible women of Saturday Night Dwell. That is supposedly more favorable for Y-chromosome (boy) sperm. A constructive being pregnant take a look at will two weeks to ...

Is she pregnant? or more often: Am I pregnant? For a long time, attempts have been made to answer this question with the help of external changes or unusual behaviours exhibited by the woman in question. And they still are: a craving for pickles, larger breasts or inexplicable irritability quickly arouse suspicion of a pregnancy. The gradual discovery of the complex control function exerted by hormones, which began in the early 20th century, gave rise to the idea that the beginning of a pregnancy can be revealed by hormonal patterns. However, it soon proved that the most important thing is determining the presence of the hormone human chorionic gonadotropin (hCG), which is produced in the placenta and is responsible for maintaining the pregnancy. This gave many researchers an opportunity to try out their methods in the search for a reliable test. Even failures were useful, as they provided new information.. Late in the 1950s, the Swedish doctor Carl Axel Gemzell and his student Leif Wide ...

LH supports theca cells in the ovaries that provide androgens and hormonal precursors for estradiol production. At the time of menstruation, FSH initiates follicular growth, specifically affecting granulosa cells.[7] With the rise in estrogens, LH receptors are also expressed on the maturing follicle, which causes it to produce more estradiol. Eventually, when the follicle has fully matured, a spike in 17α-hydroxyprogesterone production by the follicle inhibits the production of estrogens, leading to a decrease in estrogen-mediated negative feedback of GnRH in the hypothalamus, which then stimulates the release of LH from the anterior pituitary.[8] However another theory of the LH peak is a positive feedback mechanism from estradiol. The levels keep rising through the follicular phase and when they reach an unknown threshold, this results in the peak of the LH.[9] This effect is opposite from the usual negative feedback mechanism presented at lower levels. In other words, the mechanism(s) are ...

Conclusions: This novel LHCGR mutation leads to complete inactivation of the LHCGR receptor due to trafficking and signalling abnormalities, which improves our understanding of the impact of the affected structural domain on receptor trafficking and function. ...

hCG receptor兔多克隆抗体(ab125214)可与大鼠, 人样本反应并经WB, IHC实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。

PRECOCIOUS PUBERTY, MALE-LIMITED description, symptoms and related genes. Get the complete information in our medical search engine for phenotype-geno

Moudgal, NR and Krishnamurthy, HN and Surekha, S and Krishnamurthy, H and Dhople, VM and Nagaraj, R and Sairam, MR (2001) Immunobiology of a Synthetic Luteinizing Hormone Receptor Peptide 21-41. In: Journal of Andrology, 22 (6). pp. 992-998. Suguna, K and Ramakumar, S and Nagaraj, R and Balaram, P (1985) Structure of cyclo(\alpha- Aminoisobutyryl-L-phenylalanyl-), $C_{13}H_{16}N_2O_2$. In: Acta Crystallographica Section C: Crystal Structure Communications, 41 (2). pp. 284-286. Suguna, K and Ramakumar, S and Nagaraj, R and Balaram, P (1985) Structure Of Cyclo(-Alpha-Aminoisobutyryl-L-Phenylalanyl-), C13h16n2o2. In: ACTA Crystallographica Section C-Crystal Structure Communications, 41 (Feb). pp. 284-286. Francis, AK and Rao, Ch Pulla and Iqbal, M and Nagaraj, R and Vijayan, M and Balaram, P (1982) Helical conformations of three crystalline pentapeptide fragments of suzukacillin, a membrane channel forming polypeptide. In: Biochemical and Biophysical Research Communications, 106 (4). pp. 1240-1247. ...

Mechanism of the signal generation in Angler PCR. The method is based on the production of PCR amplicons, which fold into dumbbell-like secondary structures car

The LH test measures the LH blood level. This luteinizing hormone test helps evaluate fertility. Get an LH blood test near you and fast results for a low cost - Accesa Labs

Describes how the luteinizing hormone (LH) test is used, when an LH test is ordered, and what the results of an LH test might mean

2] ,pubmed,2259205,/pubmed, This article puts forward a model that hypothesizes that extracellular regulation of cell division and differentiation acts through only two communication channels. They consist of a series of redundant components: extracellular messenger hormones; these hormones receptors; cytoplasmic proteins activated by the hormone-receptor complex; and trans-activating nuclear regulatory proteins. The channels in this model are labeled as such: D (differentiate), includes transforming growth factor-beta as one of its hormones; the other, labeled G (growth) includes epidermal growth factor. The article uses a cell type in an adult mammal capable of either division or differentiation, which in this case is a stem cell from an epithelium. The principal prediction of this hypothesis is that when appropriate experimental conditions are implemented the addition of various ratios of D- and G-class growth factors will lead to different consequences. ...

2] ,pubmed,2259205,/pubmed, This article puts forward a model that hypothesizes that extracellular regulation of cell division and differentiation acts through only two communication channels. They consist of a series of redundant components: extracellular messenger hormones; these hormones receptors; cytoplasmic proteins activated by the hormone-receptor complex; and trans-activating nuclear regulatory proteins. The channels in this model are labeled as such: D (differentiate), includes transforming growth factor-beta as one of its hormones; the other, labeled G (growth) includes epidermal growth factor. The article uses a cell type in an adult mammal capable of either division or differentiation, which in this case is a stem cell from an epithelium. The principal prediction of this hypothesis is that when appropriate experimental conditions are implemented the addition of various ratios of D- and G-class growth factors will lead to different consequences. ...

Evaluation of luteinizing hormone (LH): Validation of a business ELISA package for LH evaluation and quantification in doping management samples. Luteinizing hormone (LH) is a dimeric glycoprotein produced and secreted by the pituitary… Read more ». ...

Evaluation of luteinizing hormone (LH): Validation of a business ELISA package for LH evaluation and quantification in doping management samples. Luteinizing hormone (LH) is a dimeric glycoprotein produced and secreted by the pituitary… Read more ». ...

LG Get product support for the LG 26LH20R. Download 26LH20R manuals, documents, and software. View 26LH20R warranty information and schedule services.

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Product information for Rack-Rear Access Cover-44U, Fits LHR Series, Locking/Solid, Black LHR-RAC-44 manufactured by Lowell Manufacturing Co.. Provided by AV-iQ.

Beta hCG Test Definition - A beta hCG test is a blood test that monitors levels of the hormone human chorionic gonadotropin (hCG) present in the body....

HELMDIGITAL Digital Pregnancy Test is an in-vitro diagnostic medical device for self-testing. It can easily be carried out from the first day of delay in period.. During pregnancy the body develops the hormone human Chorionic Gonadotropin (hCG) which can be detected in the urine. The device design allows an easy ejection of the test sticks. The display language and the number of strips per consumer box are variable as per customers requirements. The battery life lasts for a minimum of 5 measurements. The result is displayed within 5 minutes with an accuracy of 99% (sensitivity: 25mIU/ml).. This product has a shelf life of 2 years.. Please contact us for further details on the above presented product and the HELM Medical product portfolio. We look forward to presenting you a customized information package following your individual requirements.. ...

The following outline is provided as an overview of and topical guide to biochemistry: Biochemistry - study of chemical processes in living organisms, including living matter. Biochemistry governs all living organisms and living processes. Testing Ames test - salmonella bacteria is exposed to a chemical under question (a food additive, for example), and changes in the way the bacteria grows are measured. This test is useful for screening chemicals to see if they mutate the structure of DNA and by extension identifying their potential to cause cancer in humans. Pregnancy test - one uses a urine sample and the other a blood sample. Both detect the presence of the hormone human chorionic gonadotropin (hCG).This hormone is produced by the placenta shortly after implantation of the embryo into the uterine walls and accumulates. Breast cancer screening - identification of risk by testing for mutations in two genes-Breast Cancer-1 gene (BRCA1) and the Breast Cancer-2 gene (BRCA2)-allow a woman to ...

Adenylate cyclase activity of luteinized ovaries from gonadotropin-primed immature rats was stimulated by luteinizing hormone (LH), epinephrine and prostaglandin E1. Treatment of primed rats with human chorionic gonadotropin (hCG) caused a time-dependent loss of the adenylate cyclase response to LH, and the enzyme also became refractory to stimulation by epinephrine. Conversely, treatment of primed rats with epinephrine caused a time-dependent loss of the adenylate cyclase response to epinephrine, but the enzyme remained responsive to LH. The refractoriness of adenylate cyclase to epinephrine after desensitization by hCG or epinephrine was not reversed by Gpp(NH)p. These studies show that cross-desensitization of epinephrine-responsive adenylate cyclase activity in the ovary is induced by LH-receptor interaction, whereas β-adrenergic desensitization causes more specific refractoriness to epinephrine with no change in the LH receptor activation mechanism. This suggests the existence of ...

Fingerprint Dive into the research topics of Induction of human choriogonadotropin in HeLa-cell cultures by aliphatic monocarboxylates and inhibitors of deoxyribonucleic acid synthesis. Together they form a unique fingerprint. ...

Public Release: 8-Jan-2016 Researchers determine mechanism that triggers normal and abnormal hormone production American Society for Biochemistry and Molecular Biology IMAGE: Model of a glycoprotein hormone receptor (white backbone ribbon) with bound hormone and the activating antibody visualizes a potential arrangement and the principle mechanism of glycoprotein hormone receptor activation. view more Credit: Journal…

Clone Determination ME.116. Immunogen hLH-α subunit. Immunoglobulin Class IgG1κ. Specificity Human Luteinizing Hormone - Alpha. Purification Protein A chromatography from ascites. pI 5.0-8.0. Buffer 0.15M PBS. Preservatives None. Applications ELISA. Working dilution Determined by user. Storage Store at -20ºC to -80ºC, avoid repeat freeze-thaw cycles. FOR RESEARCH AND IN VITRO USE ONLY Contact us for bulk pricing information at 207-797-5454 or [email protected] ...

Book LH Luteinizing Hormone Lab Test appointment online at Home. View details of LH Luteinizing Hormone: procedure, normal range and Get the reports Online

Book LH Luteinizing Hormone Lab Test appointment online at Home. View details of LH Luteinizing Hormone: procedure, normal range and Get the reports Online

PERMSSN UID GID PACKED SIZE RATIO CRC STAMP NAME ---------- ----------- ------- ------- ------ ---------- ------------ ------------- [generic] 867 6584 13.2% -lh5- 2e30 May 28 1999 Lord_of_Alcandria.info [generic] 782 1832 42.7% -lh5- 7166 Jun 13 1999 Lord_of_Alcandria/af.brush [generic] 812 1792 45.3% -lh5- ec4d Jun 13 1999 Lord_of_Alcandria/af2.brush [generic] 892 1614 55.3% -lh5- 349c Jun 13 1999 Lord_of_Alcandria/edi.brush [generic] 1555 3020 51.5% -lh5- 1b17 Sep 2 1992 Lord_of_Alcandria/fonts/courier/11 [generic] 1810 3444 52.6% -lh5- bd90 Sep 2 1992 Lord_of_Alcandria/fonts/courier/13 [generic] 2198 4116 53.4% -lh5- 947e Sep 2 1992 Lord_of_Alcandria/fonts/courier/15 [generic] 2667 5156 51.7% -lh5- 357a Sep 2 1992 Lord_of_Alcandria/fonts/courier/18 [generic] 3648 7556 48.3% -lh5- 1295 Sep 2 1992 Lord_of_Alcandria/fonts/courier/24 [generic] 1596 3020 52.8% -lh5- 2264 Sep 2 1992 Lord_of_Alcandria/fonts/times/11 [generic] 1968 3548 55.5% -lh5- a3a6 Sep 2 1992 Lord_of_Alcandria/fonts/times/13 ...

Rupes LHR75E Big Foot - BAS Kit.The LHR 75E is the polisher for difficult shapes and for spot repair operations. The LHR 75E is a must for any detailer wishing to obtain perfect results, even in the most difficult areas.The 12 mm orbit, combined with RUPES accessories and consumables, achieves quick results on areas su

Jet Blast - LH942. FRA-MAN. 18/08/2019 - My daughter has had an anaphylactic event due to nuts. Lufthansa were contacted and agreed to not serve nuts

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TY - JOUR. T1 - Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. AU - Aleppo, Grazia. AU - Moskal, Stanley F.. AU - De Grandis, Paula A.. AU - Kineman, Rhonda D.. AU - Frohman, Lawrence A.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1997. Y1 - 1997. N2 - Repeated stimulation of pituitary cell cultures with GH-releasing hormone (GHRH) results in diminished responsiveness, a phenomenon referred to as homologous desensitization. One component of GHRH-induced desensitization is a reduction in GHRH-binding sites, which is reflected by the decreased ability of GHRH to stimulate a rise in intracellular cAMP. In the present study, we sought to determine if homologous down-regulation of GHRH receptor number is due to a decrease in GHRH receptor synthesis. To this end, we developed and validated a quantitative RT-PCR assay system that was capable of assessing differences in GHRH-R messenger RNA (mRNA) levels in total ...

TY - JOUR. T1 - Comparative study of the steroidogenic effects of human chorionic gonadotropin and thieno[2,3-d]pyrimidine-based allosteric agonist of luteinizing hormone receptor in young adult, aging and diabetic male rats. AU - Bakhtyukov, Andrey A.. AU - Derkach, Kira V.. AU - Gureev, Maxim A.. AU - Darin, Dmitry V.. AU - Sorokoumov, Viktor N.. AU - Romanova, Irina V.. AU - Morina, Irina Yu. AU - Stepochkina, Anna M.. AU - Shpakov, Alexander O.. N1 - Bakhtyukov, A.A.; Derkach, K.V.; Gureev, M.A.; Darin, D.V.; Sorokoumov, V.N.; Romanova, I.V.; Morina, I.Y.; Stepochkina, A.M.; Shpakov, A.O. Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. Int. J. Mol. Sci. 2020, 21, 7493.. PY - 2020/10/2. Y1 - 2020/10/2. N2 - Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact ...

The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin. We previously identified four splice variants of the LHR in human luteinized granulosa cells (LGCs) and corpora lutea (CL). Real-time quantitative PCR revealed that expression of the full-length LHR (LHRa) and the most truncated form (LHRd) changed significantly in CL harvested at different stages of the ovarian cycle (P , 0.01, ANOVA). LHRa expression was reduced in the late luteal CL (P,0.05). Conversely, an increase in LHRd expression was observed in the late luteal CL (P,0.01). Chronic manipulation of human chorionic gonadotropin in LGC primary cultures supported the in vivo findings. LHRd encodes a protein lacking the transmembrane and carboxyl terminal domains. COS-7 cells expressing LHRd were unable to produce cAMP in response to LH stimulation. COS-7 cells coexpressing LHRd and LHRa also failed to generate ...

Detects the presence of human chorionic gonadotropin (HCG), which appears in urine very early in pregnancy. Regardless of the technical language, this test works just like most other pregnancy tests out there. It measures the levels of the pregnancy hormone human chorionic gonadotropin (HCG) in your urine. This hormone is produced by the cells of the embryo that will later form the placenta. The level of HCG starts to increase from its basal level of less than 5 mIU/mL directly after implantation, and doubles about each 48 hours during the first weeks of pregnancy ...

Validity of biobank studies on hormone associated cancers depend on the extent the sample preservation is affecting the hormone measurements. We investigated the effect of long-term storage (up to 22 years) on immunoassay measurements of three groups of hormones and associated proteins: sex-steroids [estradiol, progesterone, testosterone, dihydroepiandrosterone sulphate (DHEAS), sex hormone-binding globulin (SHBG)], pregnancy-specific hormones [human chorionic gonadotropin (hCG), placental growth hormone (pGH), alpha-fetoprotein (AFP)], and insulin-like growth factor (IGF) family hormones exploiting the world largest serum bank, the Finnish Maternity Cohort (FMC). Hormones of interest were analyzed in a random sample of 154 Finnish women in the median age (29.5 years, range 25 to 34 years) of their first pregnancy with serum samples drawn during the first trimester. All hormone measurements were performed using commercial enzyme-linked- or radio-immunoassays. Storage time did not correlate with ...

when to take pregnancy test after missed period on birth control, The optimal time to take a pregnancy test is after youve missed your period, Dr. Guarnaccia says. A pregnancy test is designed to detect the presence of the hormone human chorionic gonadotropin ...

The mechanisms causing luteolysis of the primate corpus luteum are unknown. There is an increase in expression of liver x receptor (LXR) target genes and reduced low density lipoprotein receptor (LDLR) during spontaneous luteolysis in primates. The LXRs belong to the nuclear receptor superfamily and increase cholesterol efflux by inducing transcription of their target genes. Uptake of cholesterol into primate luteal cells occurs primarily via LDL, and LDLR transcription is regulated by sterol regulatory element binding transcription factor 2 (SREBF2). Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) maintain luteal function by binding to the LH/CG receptor (LHCGR), which stimulates progesterone (P4) synthesis via protein kinase A (PKA). It has also been previously reported that there is an increase in 27-hydroxycholesterol (27OH) concentrations during spontaneous luteolysis in primates. Pregnenolone and P4 inhibit the enzyme activity of CYP27A1 (cytochrome p450, family 27, ...

buy Human chorionic gonadotropin online,Human chorionic gonadotropin sale,hcg cost, Human chorionic gonadotropin,hcg vial,comprar hcg,hcg weight loss,hcg injections,buy hcg online,hcg vial,hcg price,chorionic gonadotropin,cheap hcg,wholesale hcg,purchase hcg,human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a portion of the placenta following implantation.

hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. These 5 molecules, hCG, sulfated hCG, hyperglycosylated hCG, hCG free beta and hyperglycosylated free beta are produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells (group 1), and by placental cytotrophoblast cells and human malignancies (group 2). Group 1 molecules are both hormones that act on the hCG/LH receptor. These molecules are central to human menstrual cycle and human pregnancy. Group 2 molecules are autocrines, that act by antagonizing a TGF beta receptor. These molecules are critical to all advanced malignancies. The hCG groups are molecules critical to both the molecules of pregnancy or human life, and to the advancement of cancer, or human

The glycoprotein hormones (LH, hCG, FSH, and TSH) have a common 92-amino acid alpha-subunit which is noncovalently linked to a hormone-specific beta-subunit. Synthetic peptides of the alpha-subunit have been shown to inhibit binding of [125I]iodo-hCG to rat ovarian membrane and [125I]iodo-TSH to human thyroid membrane preparations. Synthetic overlapping peptides of the alpha-subunit of hCG were prepared by solid phase techniques and tested in a standard in vitro rat Leydig cell bioassay. Three regions in the alpha-subunit (alpha 1-15, alpha 30-45, and alpha 71-85) were found to stimulate testosterone production. All three regions correlate with inhibition of hCG binding to ovarian receptors, but subtle differences exist between the binding sites and effector sites. These data indicate that the glycoprotein alpha-subunit has intrinsic bioactivity.

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TY - JOUR. T1 - Follicle-stimulating hormone receptor DNA sequencing. T2 - Investigation into possible glycoprotein receptor mutation in Van Wyk-Grumbach syndrome. AU - Sanjeevaiah, Aravind Raj. AU - Vassart, Gilbert. AU - Costagliola, Sabine. AU - Srikanta, Sri S.. PY - 2008/1/1. Y1 - 2008/1/1. UR - http://www.scopus.com/inward/record.url?scp=58149463971&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=58149463971&partnerID=8YFLogxK. U2 - 10.4158/EP.14.5.648. DO - 10.4158/EP.14.5.648. M3 - Letter. C2 - 18753112. AN - SCOPUS:58149463971. VL - 14. JO - Endocrine Practice. JF - Endocrine Practice. SN - 1530-891X. IS - 5. ER - ...

Gonadotropic hormones are required for the induction and maintenance of tumors arising in ovaries that have been transplanted to the spleens of gonadectomized mice. The characteristics of gonadotropin receptors for human chorionic gonadotropin (HCG)-luteinizing hormone on cells from these tumors of varying size, age, and morphology have been determined. The specific binding of 125I-labeled HCG to cells obtained by collagenase digestion, 15 to 65 weeks postimplantation from granulosa cell or luteinized cell, or mixed granulosa-luteal tumors was analyzed by Scatchard plot. Neither the size, weight, duration of implantation, nor histological morphology affected the receptorbinding affinity [equilibrium dissociation constant (Kd), 6 × 10-10 m], and, presumably, the receptor is qualitatively similar. In contrast, the number of HCG receptors per cell increased 17-fold and was related to the degree of morphological luteinization of the tumor. HCG-sensitive adenyl cyclase was also demonstrated and ...

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Palmitoylation of V2R was investigated by immunoprecipitation of receptor proteins expressed transiently in COS.M6 cells and detection of incorporated [3H]palmitic acid. In cells expressing the wild-type glycosylated V2R, [3H]palmitic acid incorporation resulted in the appearance of a broad radioactive band at 45-55 kDa, which is the expected size for the mature receptor form. Deglycosylation with PNGase F produced a sharp band at 40 kDa. As seen in Fig. 2, this band was identical to the band obtained from cells expressing nonglycosylated receptor (17, 18). These results demonstrated that the V2R is palmitoylated and that protein glycosylation was not required to observe palmitoylation.. Analogous to other G protein-coupled receptors, the palmitoylation site was expected to be located 10-12 amino acids downstream of the seventh transmembrane region. Some receptors, such as the α2- and β2-adrenoceptors, contain only one palmitoylated cysteine; others, like rhodopsin and the LH/hCG receptor, ...

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Human chorionic gonadotropin (medically abbreviated to hCG) is a hormone that is produced by the placenta during pregnancy. It helps to keep the pregnancy going and also has an effect on the development of the baby.

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Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones ...

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