3,407 words French translation here Beginning on September 11, 2012, US embassies and other facilities in the Muslim world have been targeted by angry mobs

Uric acid stones: These form in response to dehydration, a high protein diet, or in patients suffering from gout. A doctor may diagnose appendicitis quite easily if you have the typical symptoms. Its a difference gallstones kidney stones way to treat minor ailments, and may even prevent you from developing cancer. For hard-to-pass stones, you may mix 1 cup of lemon juice and 1 cup of extra virgin olive oil instead.

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CD158 (killer-cell immunoglobulin-like receptor, two domains) [HSA:3802 3803 3804 3805 57292 553128 3806 100132285 3808 3809 3810] [KO:K07981 K07982 ...

Understand and identify the ASHI standards that pertain to various KIR genotyping assays, and the quality control measures that must be incorporated into the test system.. ...

Toward demonstrating functional significance for the transmembrane and/or cytoplasmic portions of MICA, we generated a transfectant of Daudi expressing a truncated form of MICA in which the cysteine at position 331 was replaced with a stop codon (Daudi/Class I+/MICA/C331*). The level of cell surface staining of this transfectant with a MICA mAb was similar to that of wild-type MICA in Daudi/Class I+/MICA (Fig. 4, b and c). We tested the susceptibility of these transfectants to NK cell cytotoxicity (Fig. 4 d). A peripheral blood NK cell line was efficiently able to kill untransfected Daudi, which lacks endogenous expression of MHC class I protein, but was inhibited from killing Daudi-expressing MHC class I protein (Daudi/Class I+). In agreement with previous data (5), Daudi-expressing MHC class I protein and MICA was efficiently killed, demonstrating how activation via NKG2D recognition can overcome inhibitory signaling. However, Daudi transfectants expressing MHC class I protein and the ...

Cmon. I know that you havent a clue about medicine or how medical boards do things, but that premise is laughable. Everytime there is an incident, the state board evaluates all similar practices to make sure they are up to standards and cites those who do not. If assume that if a pain clinic used dirty needles and contaminated injectibles and killed patients with meningitis, youd want an investigation and the shutting down of all practices who failed to meet standards of care, yes? Happened in my state a few years back and it was the right thing to do--unless if you belong to the cult of abortion, I guess. As long as abortions are being performed, screw medical and ethical standards ...

TY - JOUR. T1 - Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood. AU - Della Chiesa, Mariella. AU - Falco, Michela. AU - Bertaina, Alice. AU - Muccio, Letizia. AU - Alicata, Claudia. AU - Frassoni, Francesco. AU - Locatelli, Franco. AU - Moretta, Lorenzo. AU - Moretta, Alessandro. PY - 2014/2/15. Y1 - 2014/2/15. N2 - NK cells are the first lymphoid population recovering after allogeneic hematopoietic stem cell transplantation and play a crucial role in early immunity after the graft. Recently, it has been shown that humanCMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical cord blood transplantation by accelerating the differentiation of mature NKG2A-killer Ig-like receptor (KIR)+ NK cells characterized by the expression of the NKG2C-activating receptor. In view of the hypothesis that NKG2C could be directly involved in NK cell ...

NK cells are granular lymphocytes which act as part of the innate immune system. Their activity is controlled through a balance of signals from inhibitory and activating receptors, with one important family of receptors being the killer-cell immunoglobulin-like receptors (KIR). The KIR comprise a highly polymorphic, multi-gene family of receptors whose identified ligands belong to the human leukocyte antigen (HLA) class I family of molecules. Phenotype expression of these important receptors is variable but the factors underlying this variability are not yet fully elucidated ...

The Allele Frequency Net Database (AFND) is a public database which contains frequency information of several immune genes such as Human Leukocyte Antigens (HLA), Killer-cell Immunoglobulin-like Receptors (KIR), Major histocompatibility complex class I chain-related (MIC) genes, and a number of cytokine gene polymorphisms. The Allele Frequency Net Database (AFND) provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available. We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data ...

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.: Members of the killer cell immunoglobulin-like receptor (KIR)

Comparison of mutant killer cell Ig-like receptor (KIR) 3DL1*015 substituted at natural positions of variation showed that tryptophan/leucine dimorphism at position 283 uniquely changes receptor conformation and can strongly influence binding of the A24nef tetramer. Dimorphic motifs at positions 2, 47, and 54 in D0 and 182 and 283 in D1+D2 distinguish the two 3DL1 lineages, typified by 3DL1*005 and 3DL1*015. The interlineage recombinant, KIR3DL1*001, combines D0 of 3DL1*005 with D1+D2 of 3DL1*015 and binds A24nef more strongly than either parent. In contrast, the reciprocal recombinant with D0 from 3DL1*015 and D1+D2 from 3DL1*005 cannot bind A24nef. Thus, D0 polymorphism directly affects the avidity of the KIR3DL1 ligand binding site. From these observations, multiple sequence alignment, and homology modeling, we constructed structural models for KIR3DL1 and its complex with A24nef. In these models, D0, D1, and D2 come together to form a binding surface for A24nef, which is contacted by all three Ig

The Notch signaling pathway plays a substantial role on human NK cell development, however the role of Notch on KIR upregulation and acquisition of effector function has not been explored. To evaluate how Notch influences terminal differentiation, cord blood derived NK cells or sorted KIR- peripheral blood NK cells were cultured with IL-15 for 7 days in the presence or absence of gamma-secretase inhibitor, known to inhibit Notch signaling. Inhibition of Notch signaling significantly decreased KIR expression. Conversely, co-culturing the same cells with OP9 cells bearing Notch ligands enhanced KIR expression. Overexpression of the active portion of Notch on cord blood derived NK cells after 28 days of culture resulted in a 2-fold increase in KIR expression indicating that Notch signaling plays a direct, cell intrinsic, role in KIR regulation. By knocking down delta-like 1 (DLL1) on NK cells and co-culturing them with OP9 cells expressing Notch ligands we show that DLL1 mediated cis-inhibition ...

Previous studies revealed that HCMV infection induces a persistent reconfiguration of the NK cell compartment characterized by the expansion of an NK cell subset expressing the activating NKG2C receptor. This finding has been demonstrated both in healthy individuals and in patients with different pathological conditions (10-16, 30, 31). Remarkably, in patients undergoing UCBT, HCMV infection/reactivation markedly influenced NK cell reconstitution, promoting the rapid appearance and expansion of NKG2C+KIR+NKG2A−Siglec-7− NK cells (17, 18). These studies suggested that the NKG2C activating receptor could play a crucial role in NK cell expansion and/or maturation driven by HCMV infection.. In the present study, we analyzed the maturation and function of NK cells developing in three patients transplanted with cord blood cells from donors carrying homozygous deletion of the NKG2C gene and undergoing HCMV infection. These cases offered a unique opportunity to analyze the features of NK cell ...

The HLA-C locus is distinct relative to the other classical HLA class I loci in that it has relatively limited polymorphism, lower expression on the cell surface, and more extensive ligand-receptor interactions with killer-cell immunoglobulin-like receptors. A single nucleotide polymorphism (SNP) 35 …

Christopher Johnson is the author of this article in the Journal of Visualized Experiments: qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes

When T cells, B cells, and natural killer (NK) cells of the immune system interact with target cells, signaling molecules are accumulated in the plasma membrane at structures known as the immunological synapse. Evidence is accumulating that proteins, as well as signals, are transferred between the interacting cells at such contacts. NK cells receive inhibitory signals from cells that express self major histocompatibility complex (MHC) molecules on their surface. Earlier evidence had shown that NK cells can actually acquire MHC class I proteins during interactions with target cells. Now Vanherberghen et al. show that the exchange goes both ways and that NK receptors are transferred to cells that express MHC class I ligands. The authors monitored transfer of biotinylated killer Ig-like receptor (KIR) KIR2DL1 by immunoblotting or green fluorescent protein-tagged receptor by fluorescence-activated cell sorting or laser-scanning confocal microscopy and observed transfer of KIRs. The NK cell receptor ...

Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:97081 IMAGE:7262296), complete cds ...

TY - JOUR. T1 - Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family. AU - Yawata, Makoto. AU - Yawata, Nobuyo. AU - Abi-Rached, Laurent. AU - Parham, Peter. PY - 2002. Y1 - 2002. N2 - The killer cell immunoglobulin-like receptors (KIR) form a family of highly homologous immune receptors that regulate the response of natural killer (NK) cells and some T cells. The genetics of the human KIR family is reviewed in this article. In human populations, diversity in KIR genotype arises from variations in gene content and allelic polymorphism. Comparisons of 81 human KIR sequences reveal past events of gene duplication and recombination, and indicate that individual KIR genes have diversified from the influence of natural selection. Comparison and compilation of population studies reveal extensive KIR genotype variability within human populations and among them. Genomic analysis shows the KIR genes to be close to each other and separated by homologous sequences that ...

TY - JOUR. T1 - Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population. AU - Wang, Hong Dan. AU - Zhu, Bo Feng. AU - Shen, Chun Mei. AU - Yuan, Guo Lian. AU - Yang, Guang. AU - Guo, Juan Ning. AU - Yan, Jiang Wei. AU - Qin, Hai Xia. AU - Guo, Jian Xin. AU - Zhang, Li Ping. AU - Jia, Xiao Qin. AU - Lucas, Rudolf. PY - 2012/3/1. Y1 - 2012/3/1. N2 - Abstract Human killer cell immunoglobulin-like receptors are expressed in natural killer cells and subsets of T lymphocytes. They regulate these cells upon interaction with human leukocyte antigen class I molecules and other ligands presented by target cells. KIR gene frequencies and haplotype distributions have been shown to differ significantly between populations from different geographical regions and ethnic origins, which relates to functional variations in the immune response. We have investigated KIR gene frequencies and genotype diversities of 15 KIR genes (KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5, ...

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis patients and 110 healthy controls using sequence-specific primer PCR analysis of genomic DNA.

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Looking for Killer Cell Inhibitory Receptor? Find out information about Killer Cell Inhibitory Receptor. Physiol a sensory nerve ending that changes specific stimuli into nerve impulses a sensory nerve structure that perceives and transforms stimuli from an... Explanation of Killer Cell Inhibitory Receptor

Killer immunoglobulin-like receptors (KIRs) are expressed on natural killer cells and some T-cell subsets and produce either activation or inhibitory signals upon binding with the appropriate human leucocyte antigen (HLA) ligand on target cells. Recent genetic association studies have implicated KIR

The question we are addressing is: how does the maternal immune system regulate placentation in humans? Our view of the fetal allograft is one of cooperation between mother and fetus. We focus on how the dominant population of uterine leukocytes, Natural Killer (NK) cells, that have receptors for HLA class I ligands on fetal trophoblast cells, regulate trophoblast function.. We work in close collaboration with Dr Francesco Colucci in the Department of Obstetrics and Gynaecology.. The main areas of current research are:. 1) Interactions between maternal Killer-cell Immunoglobulin-like Receptor (KIR) and fetal HLA-C molecules. Because both KIR and HLA-C genes are highly polymorphic, each pregnancy is likely to be different. Our genetic and functional studies in Europeans and Africans show certain KIR/HLA-C genetic combinations are associated with extremes of the normal birth weight distribution.. 2) Culture of human trophoblast cells. Studies on pregnancy disorders are limited because trophoblast ...

Natural Killer (NK) cell responses are shaped by the integration of signals transduced from multiple activating and inhibitory receptors at their surface. Biochemical and genetic approaches have identified most of the key proteins involved in signal integration but a major challenge remains in understanding how the spatial and temporal dynamics of their interactions lead to NK cells responding appropriately when encountering ligands on target cells. Well over a decade of research using fluorescence microscopy has revealed much about the architecture of the NK cell immune synapse - the structured interface between NK cells and target cells - and how it varies when inhibition or activation is the outcome of signal integration. However, key questions - such as the proximity of individual activating and inhibitory receptors - have remained unanswered because the resolution of optical microscopy has been insufficient, being limited by diffraction. Recent developments in fluorescence microscopy have broken

HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhibitory killer cell immunoglobulin-like receptor KIR3DL1 as the only significant modifier of B*57 protection. The association was replicated in an independent cohort and across multiple outcomes. The modifying effect of I47V was confined to B*57:01 and was not observed for the closely related B*57:03. Positions 2, 47, and 54 tracked one another nearly perfectly, and 2 KIR3DL1 allotypes differing only at these 3 positions showed significant differences in binding B*57:01 tetramers, whereas the protective allotype showed lower binding. Thus, variation in an immune NK cell receptor that binds B*57:01 modifies ...

HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhibitory killer cell immunoglobulin-like receptor KIR3DL1 as the only significant modifier of B*57 protection. The association was replicated in an independent cohort and across multiple outcomes. The modifying effect of I47V was confined to B*57:01 and was not observed for the closely related B*57:03. Positions 2, 47, and 54 tracked one another nearly perfectly, and 2 KIR3DL1 allotypes differing only at these 3 positions showed significant differences in binding B*57:01 tetramers, whereas the protective allotype showed lower binding. Thus, variation in an immune NK cell receptor that binds B*57:01 modifies ...

Natural killer (NK) cells play key roles in innate and adaptive immune responses against virus and tumor cells. Their function relies on the dynamic balance between activating and inhibiting signals through receptors that bind ligands expressed on target cells. The absence of inhibitory receptor engagement with their ligands and the presence of activating signals transmitted by activating receptors interacting with specific ligands, leads to NK cell activation (Lanier, 2005; Raulet et al., 2001). Thus, the balance of the ligands expressed for inhibitory and activating receptors determines whether NK cells will become activated to kill the target cells. This protocol allows to assign a precise ligand specificity to any given receptor on NK cells. Thus, if a tumor cell expresses the ligand, this protocol will allow to evaluate its interaction with the specific receptor. In particular, killer cell immunoglobulin (Ig)-like receptors (KIR) recognize their ligands (HLA class I molecules) through the direct

KIR2DS2 Full-Length MS Protein Standard (NP_036444), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine

Natural killer (NK) cells are lymphocytes of the innate immune system that fight infection by producing cytokines and killing infected cells. Their functional activity is regulated by the interaction between their surface killer cell immunoglobulin-like receptors (KIR) and Class I HLA alleles expressed on the target cell. NK cells will contain more than one type of KIR on their surface and these receptors can be either inhibitory or activating in nature.. There are 14 KIR genes and two pseudogenes located in the leukocyte receptor complex (LRC) on chromosome 19q13.4. Human NK cells express various combinations of these 16 KIR genes with two common haplotypes: Group A, which has more inhibitory receptors and Group B, which has more activating receptors.. ...

Natural killer cell An innate effecter cells of immune system limits viremia and tumor burden Natural killer cell, also called NK cell, is a cell with large particles in the cytoplasm. NK cell is developed from bone marrow lymphoid stem cells, and its differentiation and development depend on bone marrow or thymus microenvironment, mainly distributed in peripheral blood and spleen, and a small amount in lymph nodes and other tissues. It is named because of its non-specific cytotoxicity. Without the receptors of T cells and B cells, there will be no genetic recombination of the recipient. But it still has some special receptors called "Killer cell immunoglobulin-like receptors (KIR)". KIR are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of NK cell function. NK cell is accounted about 5~10% of all lymphocytes, but NK cell can eliminate many kinds of pathogens and many kinds of tumor cells. NK cell contact with

PE anti-human CD158d (KIR2DL4) Antibody - CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains.

The KIR (Killer cell immunoglobulin-like receptor) gene cluster is a region of approximately 150 kb within the Leukocyte Receptor Complex (LRC) on human chromosome 19q13.4 (CM000681.2: 50900001-58617616). The KIR family is highly divergent, with multiple haplotypes differing in gene content, and with individual genes exhibiting allelic variation. Only a few KIR genes are conserved between humans and chimpanzees, the closest living relatives to humans. The GRCh38 assembly includes 35 representations for the LRC-KIR region as alternate loci scaffolds in addition to the chromosomal sequence (ALT_REF_LOCI in LRC-KIR region). David Roe and colleagues (personal communication) recently sequenced a diverse panel of KIR haplotypes with the goal to report novel structures and to demonstrate the ability to fully characterize KIR haplotypes, even across long repetitive sequences in diploid individuals.The sequences for these 15 haplotypes are derived from 8 individuals (one is homozygous for the haplotype). ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

In this study, we report that CD4+ T cells in patients with ACS have undergone profound changes in gene expression and function. Most significantly, these CD4+ T cells have entered a program of successive de novo expression of genes encoded in the LRC on chromosome 19. The acquisition of KIR2DS2 and its signaling protein, DAP12, endowed CD4+ T cells with cytolytic capability. CD158j+DAP12+CD4+ T cells were exclusively found in patients with ACS, emphasizing an association between such specialized T cells and plaque instability. Preliminary data on T-cell lines established from tissue debris collected by distal embolization protection during angioplasty indicate that CD4+DAP12+ T cells accumulate in the unstable lesion (authors unpublished data, 2003). Triggering of CD158j bypassed the need for T-cell receptor signaling to initiate endothelial cell lysis. We propose that the aberrant expression of LRC-encoded genes on CD4+ T cells can break self-tolerance, a mechanism possibly contributing to ...

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Journal of Cell Science is pleased to be a part of the new and exciting Review Commons initiative, launched by EMBO and ASAPbio. Streamlining the publishing process, Review Commons enables high-quality peer review to take place before journal submission. Papers submitted to Review Commons will be assessed independently of any journal, focusing solely on the papers scientific rigor and merit.. ...

Mouse monoclonal KIR2DL1 + KIR2DL3 + KIR2DL4 + KIR2DS4 antibody [2H6] validated for WB, ELISA and tested in Human. Immunogen corresponding to recombinant full…

This graph shows the total number of publications written about Receptors, KIR3DL1 by people in this website by year, and whether Receptors, KIR3DL1 was a major or minor topic of these publications ...

Recombinant protein of human leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), transcript variant a, 20 ug available for purchase from OriGene - Your Gene Company.

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A Rubicon t rt nelmi foly irat honlapja. A tartalma szerint tudom nyos ismeretterjeszt foly irat magazinszer en n pszer s ti a t rt nelmet. Ahogy az iskol ban nem hallhatta...

A Rubicon t rt nelmi foly irat honlapja. A tartalma szerint tudom nyos ismeretterjeszt foly irat magazinszer en n pszer s ti a t rt nelmet. Ahogy az iskol ban nem hallhatta...

Killer cell immunoglobulin-like receptors (KIR) inhibit the cytotoxic activity of natural killer (NK) cells by recruitment of the tyrosine phosphatase SHP-1 to immunoreceptor tyrosine-based inhibition motif (ITIM) sequences in the KIR cytoplasmic tai

The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed. A systematic literature search was performed in electronic databases including Scopus and PubMed/MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk. Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc. The current meta-analysis

TY - JOUR. T1 - Killer immunoglobulin-like receptor and human leukocyte antigen-C genotypes in rheumatoid arthritis primary responders and non-responders to anti-TNF-α therapy. AU - McGeough, Cathy. AU - Berrar, Daniel. AU - Wright, Gary. AU - Mathews, Clare. AU - Gilmore, Paula. AU - Cunningham, Rodat T.. AU - Bjourson, AJ. PY - 2011. Y1 - 2011. U2 - 10.1007/s00296-011-1838-6. DO - 10.1007/s00296-011-1838-6. M3 - Article. VL - 32. SP - 1647. JO - Rheumatology International. JF - Rheumatology International. SN - 0172-8172. IS - 6. ER - ...

The KIR Typing Kit allows the detection of human killer cell immunoglobulin-like receptors (KIRs) on genomic DNA level or the analysis of KIR expression on mRNA level.1-5 The presence or absence of KIR genes is analyzed by PCR using carefully designed sequence-specific primers (SSPs), enabling the detection of all known 15 human KIR genes plus two pseudo genes. Allel coverage: IPD KIR Sequence database release 2.1, March 2009 (http://www.ebi.ac.uk/ipd/) Each well of the 96-well PCR plate contains a lyophilized enzyme mix, including Taq DNA Polymerase, as well as positive control primers. Resuspension Buffer is simply mixed with the template and dispensed into the wells of the PCR plate. PCR products are ready for immediate analysis by electrophoresis due to the integrated gel loading buffer. - Deutschland

Clone REA860 recognizes the human CD158i antigen, also known as KIR2DS4, a member of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and some T cells. CD158i (KIR2DS4) provides an activation signal for NK lytic activity upon interaction with its ligand, HLA-Cw4, in an antigen-independent manner. KIRs are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains. The receptor family can be subdivided functionally according to the length of their cytoplasmic tail in inhibitory and activating KIRs. Additional information: Clone REA860 displays negligible binding to Fc receptors. - Latvija

Methods Peripheral blood mononuclear cells (PBMCs) of 36 MMs and 28 HCs were analysed for the level of perforin, interferon-regulating transcription factor-1 (IRF-1), DAP10 and Src homology 2 domain-containing tyrosine phosphatase-1 by reverse transcriptase PCR, level of phosphorylated signal transducers and activators of transcription (pSTAT)-1, pSTAT-4, pSTAT-5 by western blot and interferon (IFN)-γ production by ELISA. The expression of activating NKG2D and inhibitory killer immunoglobulin-like receptors (KIR), CD158a and CD158b, on PBL, CD3−CD56+ natural killer (NK) cells and CD3+CD8+ cytotoxic T lymphocytes (CTLs), as well as the percentage of CD14+HLA-DR- cells in PBMC were estimated by flow cytometry. ...

Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J. 1999 Aug 02; 18(15):4250-60 ...

Dishub telah menganggarkan pembelian alat perlengkapan uji KIR sebesar Rp5,6 Milyar. Saat ini, untuk pengadaan alat tersebut masih pada tahap pelelangan

從中國人外周血單個核細胞胎盤組織和肝癌組織等樣品中克隆了包含完整hla - g1讀框的cdna與國外同行獲得的該基因及其蛋白質序列比較分析表明，該基因雖然有著細微的種族特異性，但高度保守並獲得了它的截斷型重組蛋白，根據蛋白一級結構和同源比較方法，模建了它及其與特異性受體kir2dl4形成復合體的空間結構模擬，預測了它們之間相互作用的特徵 ...

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