In a series of previous studies, it was shown that immunologic inhibition of tumor growth (immunosurveillance) could be undermined in several different tumor models by tumor-induced secretion of TGF-β1 and the inhibitory effect of this cytokine on tumor antigen-specific cytolytic T cells ( 2, 10- 13). Furthermore, it was shown that such counter-immunosurveillance was initiated by NKT cells that secrete IL-13 and thereby induce Gr-1 cells to produce TGF-β1 ( 1- 3, 13). These studies led to attempts to treat tumors by disarming counter-immunosurveillance. Although these included the use of antagonists that block the activity of either of the above cytokines, they did not include approaches that address key signaling mechanisms involved such as those mediating IL-13 induction of TGF-β1 because the latter were as yet poorly understood.. With regard to this latter point, previous studies showing that IL-13 signals via the type II IL-4R, a heterodimer of the IL-4Rα and IL-13Rα1 that responds to ...
Hepatitis C virus (HCV) causes hepatitis, liver cirrhosis and hepatocellular carcinoma, and may also induce type II mixed cryoglobulinemia syndrome (MC), a disease characterized by clonal B-cell lymphoproliferations that can evolve into non-Hodgkins lymphoma (NHL). Interleukin-1 (IL-1) is a cytokine that plays an important role in initiating the cascade of events of immunoinflammatory responses through costimulation of T lymphocytes, B-cell proliferation, induction of adhesion molecules and stimulation of the production of other inflammatory cytokines. The role of IL-1 in immunoinflammatory responses is highlighted by the presence of endogenous regulators (IL-1 receptor antagonist, soluble receptors type 1 and II, human IL-1 accessory protein) that, when secreted into the blood stream may serve as endogenous regulators of IL-1 action. The aim of this study was to evaluate whether abnormalities in the blood levels of IL-1β IL-1 receptor antagonist, soluble IL-1 receptor type II and human IL-1 ...
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. ...
TY - JOUR. T1 - Interleukin-1β, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. AU - Cannon, Joseph Gerard. AU - Angel, Jonathan B.. AU - Abad, Leslie W.. AU - Vannier, Edouard. AU - Mileno, Maria D.. AU - Fagioli, Laura. AU - Wolff, Sheldon M.. AU - Komaroff, Anthony L.. PY - 1997/7/3. Y1 - 1997/7/3. N2 - Chronic fatigue syndrome is a condition that affects women in disproportionate numbers, and that is often exacerbated in the premenstrual period and following physical exertion. The signs and symptoms which include fatigue, myalgia, and low-grade fever, are similar to those experienced by patients infused with cytokines such as interleukin-I. The present study was carried out to test the hypotheses that (1) cellular secretion of interleukin-1β (IL-1β), interleukin-1 receptor antagonist (IL-1Ra), and soluble interleukin-1 receptor type II (IL-1sRII) is abnormal in female CFS patients compared to age- and activity-matched ...
Interleukin-2 is a remarkable activator of lymphocytes with anti-neoplastic properties such as T-cells or natural killer cells, but tumor regression only rarely occurs in interleukin-2-treated cancer patients. In this review, we focus on interactions between monocytes/macrophages and T-cells/natural killer-cells, and in particular the role of such interactions for the outcome of cancer immunotherapy with interleukin-2. We propose that interleukin-2 therapy should be supplemented with compounds that alleviate toxicity inflicted by monocyte/macrophage-derived reactive oxygen metabolites within and around tumors. The hypothesis is founded on data demonstrating that (i) functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen metabolites, generated by neighboring monocytes/macrophages, (ii) interleukin-2 only weakly activates T-cells or natural killer cells in an environment of oxidative stress, and (iii) inhibitors of the formation of reactive oxygen ...
Background and purpose: The inflammatory cytokine interleukin-1 (IL-1) has profound actions in the brain causing neuronal cell death and exacerbating mind damage. barrier model was generated by co-culture of porcine mind microvascular endothelial cells with astrocytes. The mechanisms of transcellular transport of IL-1β and IL-1 receptor antagonist were characterized with this model using endocytosis inhibitors and IL-1 receptor-blocking antibodies. Important results: Transcellular IL-1β and IL-1 receptor DMH-1 antagonist transport was temperature-dependent and IL-1β was transferred with higher affinity than IL-1 receptor antagonist. IL-1β inhibited IL-1 receptor antagonist transport more potently than IL-1 receptor antagonist inhibited IL-1β transport. Transport of IL-1β and IL-1 receptor antagonist was not via adsorptive-mediated endocytosis although inhibition of microtubule assembly significantly attenuated transport of both cytokines. An antibody directed DMH-1 to the type II IL-1 ...
CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiti
Complete information for IL1RAPL1 gene (Protein Coding), Interleukin 1 Receptor Accessory Protein Like 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
LG Decoy vs Motorola Renegade V950. Compare the specs and features of the LG Decoy and Motorola Renegade V950 to see which is better.
In the United States, the term pen usually describes outdoor small enclosures for holding animals. These may be for encasing livestock or pets that cannot be kept indoors. Pens may be named by their purpose, such as a holding pen, used for short-term confinement. A pen for cattle may also be called a corral, a term borrowed from the Spanish language. Groups of pens that are part of a larger complex may be called a stockyard, where a series of pens holds a large number of animals, or a feedlot, which is type of stockyard used to confine animals that are being fattened. A large pen for horses is called a paddock (Eastern USA) or a corral (Western USA). In some places an exhibition arena may be called a show pen. A small pen for horses (no more than 15-20 feet on any side) is only known as a pen if it lacks any roof or shelter, otherwise it is called a stall and is part of a stable. A large fenced grazing area of many acres is called a pasture, or, in some cases, rangeland.[citation needed] ...
Complete information for MRAP gene (Protein Coding), Melanocortin 2 Receptor Accessory Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Platelet-activating factor acetylhydrolase precursor (EC 3.1.1.47) (PAF acetylhydrolase) (PAF 2-acylhydrolase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (2-acetyl-1-alkylglycerophosphocholine esterase) (1-alkyl-2-acetylglycerophosphocholine esterase) [Source:Uniprot/SWISSPROT;Acc:Q90678 ...
Rabbit anti Human interleukin-1R accessory protein antibody recognizes IL-IL-1RAcP (IL-1 receptor accessory protein), an essential protein
A decoy receptor is a receptor that is able to recognize and bind specific growth factors or cytokines efficiently, but is not structurally able to signal or activate the intended receptor complex. It acts as an inhibitor, binding a ligand and keeping it from binding to its regular receptor. Decoy receptors participate in a common methods of signal inhibition and are also abundant in malignant tissues, making up a significant topic in cancer research. IL1R2 was one of the first identified decoy receptors. It binds IL1A and IL1B and inhibits their binding to IL1R1, deterring the inflammatory response which is generally promoted by the binding of type 1 interleukins to interleukin receptor 1 type I. Also known as TNFRSF6, the DcR3 receptor is found primarily in human malignant tissues. It acts as a decoy receptor for TNF cytokine members: FasL, LIGHT, and TL1A, inhibiting the ability of the cytokines to signal for cell death or apoptosis. VEGFR-1 is a kinase-defective receptor tyrosine kinase that ...
Tcl1兔多克隆抗体(ab32813)可与人样本反应并经WB实验严格验证,被1篇文献引用。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Summary of CACNA1F (AIED, Cav1.4, CORDX3, CSNB2, CSNB2A, CSNBX2, JM8, JMC8, OA2) expression in human tissue. Expression in photoreceptors in retina.