Conclusions: This novel LHCGR mutation leads to complete inactivation of the LHCGR receptor due to trafficking and signalling abnormalities, which improves our understanding of the impact of the affected structural domain on receptor trafficking and function. ...

Gonadotropic hormones are required for the induction and maintenance of tumors arising in ovaries that have been transplanted to the spleens of gonadectomized mice. The characteristics of gonadotropin receptors for human chorionic gonadotropin (HCG)-luteinizing hormone on cells from these tumors of varying size, age, and morphology have been determined. The specific binding of 125I-labeled HCG to cells obtained by collagenase digestion, 15 to 65 weeks postimplantation from granulosa cell or luteinized cell, or mixed granulosa-luteal tumors was analyzed by Scatchard plot. Neither the size, weight, duration of implantation, nor histological morphology affected the receptorbinding affinity [equilibrium dissociation constant (Kd), 6 × 10-10 m], and, presumably, the receptor is qualitatively similar. In contrast, the number of HCG receptors per cell increased 17-fold and was related to the degree of morphological luteinization of the tumor. HCG-sensitive adenyl cyclase was also demonstrated and ...

par Yves Combarnous Directeur de Recherche émérite CNRS Physiologie de la Reproduction & des Comportements (UMR INRA - CNRS 7237)Cette lecture publique est organisée dans le cadre de la conférence ICGRIII - International Conference on Gonadotropins & Receptors

H. Krishnamurthy obtained his PhD from the Manipal University (formerly known as Manipal Academy of Higher Education), Manipal, India (1997) in Radiation Biology. From 1997 to 2001, he underwent postdoctoral training at the Institute for Reproductive Medicine, Muenster, Germany: Institute for Clinical Research, Montreal, Canada and University of Iowa, Iowa, USA. Later, he moved to Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA as Associate Research Scientist and Managing Director of the flow cytometry facility. At present, he is working as Scientific Officer E and in charge of Flow Cytometry and Confocal Microscopy Facilities at the National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India. His research interest is hormonal regulation of spermatogenesis and trafficking and signaling of gonadotropin receptors. He has served The Cytometry Society, India as general secretary (research) and education committee of the ...

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The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G | C) that was 142 bp from insLQ. The association of the insLQ and rs4073366 alleles and outcome to COH (number of mature follicles, estradiol level on day of human chorionic gonadotropin (hCG) administration, the number of eggs retrieved and ovarian hyperstimulation syndrome (OHSS)) was determined. Increasing age and higher day 3 (basal) FSH levels were significantly associated with poorer response to COH. We found that both insLQ and rs4073366 were in linkage disequilibrium (LD) and no patients were homozygous for both recessive

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www.MOLUNA.de Structure and Function of the Gonadotropins [4203542] - In September of 1977 scientists from many countries met at the Asticou Inn in Maine to present and discuss papers written especially for this monograph. The presentations were informal and directed to the special interests of the audience in order to generate discussions. The authors, many of whom are pioneers

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Aatsinki JT, Pietila EM, Lakkakorpi JT and Rajaniemi HJ (1992). Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. Mol. Cell Endocrinol. 84: 127-135. http://dx.doi.org/10.1016/0303-7207(92)90079-L Apaja PM, Tuusa JT, Pietila EM, Rajaniemi HJ, et al. (2006). Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum. Mol. Biol. Cell 17: 2243- 2255. http://dx.doi.org/10.1091/mbc.E05-09-0875 PMid:16495341 PMCid:1446094 Ascoli M, Fanelli F and Segaloff DL (2002). The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr. Rev. 23: 141-174. http://dx.doi.org/10.1210/er.23.2.141 PMid:11943741 Bacich DJ, Rohan RM, Norman RJ and Rodgers RJ (1994). Characterization and relative abundance of alternatively spliced luteinizing hormone receptor messenger ribonucleic acid in the ovine ovary. Endocrinology 135: 735-744. ...

TY - JOUR. T1 - A role for neurotransmitters in early follicular development. T2 - Induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. AU - Mayerhofer, Artur. AU - Dissen, Gregory A.. AU - Costa, Maria E.. AU - Ojeda, Sergio R.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - The initiation of follicular growth in the mammalian ovary is a gonadotropin-independent phenomenon. Although some of the intraovarian signaling molecules that control the later phases of this process have been recently identified, the factors involved in the acquisition of gonadotropin receptors by early growing follicles have not been fully defined. In the rat, development of the ovarian innervation precedes the onset of folliculogenesis and occurs before follicles acquire responsiveness to gonadotropins. Because vasoactive intestinal polypeptide (VIP) and norepinephrine (NE), two of the neurotransmitters contained in ovarian nerves, are present in the ovary before the gland ...

The present study was designed to characterize the regulation of the type II corticosteroid receptor (GR) mRNA in two tissues involved in the control of the hypothalamic-pituitary-adrenal axis. We have used a solution hybridization/S1 nuclease protection assay to quantitate GR mRNA levels in the rat …

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Human Chorionic Gonadotropin is also called Human Gonadotropin. Its a glycoprotein hormone produced during pregnancy, and also made by the embryo just after conception and then by the trophoblast.

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Pregnant mare serum gonadotropin (PMSG) dan human chorionic gonadotropin (hCG) merupakan hormon yang biasa digunakan untuk program stimulasi. Hormon ini dapat digunakan untuk menstimulasi perkembangan folikel ovarium ...

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Thehistory of the gonadotropins covers an amazingly short period of time considering the important role they play in basic physiology throughout the vertebrate animal kingdom. It is in fact confined...

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Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

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The choriogonadotropin beta-subunit radioimminoassay has been used extensively to measure human choriogonadotropin in the sera of pregnant women and individuals with trophoblastic and nontrophoblastic tumors. Unmodified, this method cannot be used to measure choriogonadotropin in urine because of interfering substances. We circumvented the non-parallelism between the standards and serial dilutions of urine containing choriogonadotropin by adding pooled urine from men to the standard tubes and limiting the volume of urine to 100 microliter. This modified assay has a sensitivity of 3 int. units/liter of urine and is specific for choriogonadotropin concentrations of 40 int. units/liter of urine. Analytical recovery of choriogonadotropin added to urine ranged from 96 to 105%. The within-assay CV was 7.6%; the between-assay CV was 11.8%. Concentrations of choriogonadotropin in concurrently collected serum and urine samples from pregnant women correlated well. The test can be performed within 24 h by ...

Human Chorionic Gonadotropin Definition Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone, which similar in structure to luteinizing hormone tha

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Human chorionic gonadotropin is a normally happening hormone that is found in pregnant ladies. It is regularly used to recognize pregnancy. HUCOG 10000 I.U

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Humani horionski gonadotropin interaguje sa LHCG receptorom i promoviše corpus luteum održavanje tokom početka trudnoće. hCG izaziva sekreciju hormona progesterona iz njega. Progesteron obogaćuje matericu sa debelim oblogom krvnih sudova i kapilara, tako da ona može da održava rastući fetus. Usled njegovog visoko negativnog naelektrisanja, hCG može da odbije imunske ćelije majke, čime štiti fetus tokom prvog tromesečja. Takođe se pretpostavlja da hCG može da bude materična veza za razvoj lokalne maternje imunotolerancije. Na primer, endometrialne ćelije tretirane hCG-om uzrokuju povišenje T ćelijske apoptoze. Ti rezultati sugerišu da hCG može da bude veza u razvoju peritrofoblastne imunske tolerancije, i da on može da olakša invaziju trofoblasta, za šta je poznato da ubrzava fetalni razvoj u endometrijumu.[3] Predloženo je da su hCG nivoi povezani sa ozbiljnošću jutarnje mučnine kod trudnih žena.[4] ...

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TY - JOUR. T1 - Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. AU - Aleppo, Grazia. AU - Moskal, Stanley F.. AU - De Grandis, Paula A.. AU - Kineman, Rhonda D.. AU - Frohman, Lawrence A.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1997. Y1 - 1997. N2 - Repeated stimulation of pituitary cell cultures with GH-releasing hormone (GHRH) results in diminished responsiveness, a phenomenon referred to as homologous desensitization. One component of GHRH-induced desensitization is a reduction in GHRH-binding sites, which is reflected by the decreased ability of GHRH to stimulate a rise in intracellular cAMP. In the present study, we sought to determine if homologous down-regulation of GHRH receptor number is due to a decrease in GHRH receptor synthesis. To this end, we developed and validated a quantitative RT-PCR assay system that was capable of assessing differences in GHRH-R messenger RNA (mRNA) levels in total ...

TY - JOUR. T1 - Comparative study of the steroidogenic effects of human chorionic gonadotropin and thieno[2,3-d]pyrimidine-based allosteric agonist of luteinizing hormone receptor in young adult, aging and diabetic male rats. AU - Bakhtyukov, Andrey A.. AU - Derkach, Kira V.. AU - Gureev, Maxim A.. AU - Darin, Dmitry V.. AU - Sorokoumov, Viktor N.. AU - Romanova, Irina V.. AU - Morina, Irina Yu. AU - Stepochkina, Anna M.. AU - Shpakov, Alexander O.. N1 - Bakhtyukov, A.A.; Derkach, K.V.; Gureev, M.A.; Darin, D.V.; Sorokoumov, V.N.; Romanova, I.V.; Morina, I.Y.; Stepochkina, A.M.; Shpakov, A.O. Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. Int. J. Mol. Sci. 2020, 21, 7493.. PY - 2020/10/2. Y1 - 2020/10/2. N2 - Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact ...

Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies ...

TY - JOUR. T1 - Follicle-stimulating hormone receptor DNA sequencing. T2 - Investigation into possible glycoprotein receptor mutation in Van Wyk-Grumbach syndrome. AU - Sanjeevaiah, Aravind Raj. AU - Vassart, Gilbert. AU - Costagliola, Sabine. AU - Srikanta, Sri S.. PY - 2008/1/1. Y1 - 2008/1/1. UR - http://www.scopus.com/inward/record.url?scp=58149463971&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=58149463971&partnerID=8YFLogxK. U2 - 10.4158/EP.14.5.648. DO - 10.4158/EP.14.5.648. M3 - Letter. C2 - 18753112. AN - SCOPUS:58149463971. VL - 14. JO - Endocrine Practice. JF - Endocrine Practice. SN - 1530-891X. IS - 5. ER - ...

Human chorionic gonadotropin (medically abbreviated to hCG) is a hormone that is produced by the placenta during pregnancy. It helps to keep the pregnancy going and also has an effect on the development of the baby.

The hCG hormone better known as Human Chorionic Gonadotropin is produced at the time of pregnancy. It is constructed by those cells which form the placenta, nourishes the fertilized egg and then attaches to the uterine wall.

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