Type 2 Fibroblast Growth Factor Receptor: A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME.

The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions. We have used Cre-mediated excision to generate mice lacking the IIIb form of fibroblast growth factor receptor 2 whilst retaining expression of the IIIc form. Fibroblast growth factor receptor 2(IIIb) null mice are viable until birth, but have severe defects of the limbs, lung and anterior pituitary gland. The development of these structures appears to initiate, but then fails with the tissues undergoing extensive apoptosis. There are also developmental abnormalities of the salivary glands, inner ear, teeth and skin, as well as minor defects in skull formation. Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis.. ...

Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 has complete details about market of Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 industry, Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 analysis and current trends.

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017 ...

TY - JOUR. T1 - Coexpression of truncated human cytomegalovirus gh with the ul115 gene product or the truncated human fibroblast growth factor receptor results in transport of gh to the cell surface. AU - Spaete, Richard R.. AU - Perot, Karen. AU - Scott, Patricia I.. AU - Nelson, Jay A.. AU - Stinski, Mark F.. AU - Pachl, Carol. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1993/4. Y1 - 1993/4. N2 - The gH glycoprotein of herpesviruses is located on the cell surface in viral-infected cells but is retained in the endoplasmic reticulum (ER) when expressed separately from a recombinant expression vector. These observations suggested the requirement for either a viral function or a viral-induced cellular function which facilitates surface expression of gH, gL fulfills this role in the herpes simplex virus (HSV)-infected cell (J. Virol. 66, 2240-2250, 1992). We have identified the gene product of the UL115 open reading frame (ORF) as the functional homologue of HSV gL in ...

Fibroblast growth factor receptor (FGFR) is a receptor-type protein tyrosine kinase. Currently known FGFR mainly includes 4 types, namely FGFR1, FGFR2, FGFR3 and FGFR4. It has been clinically found that FGFR overexpression and activation of tumor tissues in a variety of cancers can promote tumor angiogenesis and tumor cell division and proliferation. Therefore, fibroblast growth factor receptors are widely regarded as an important class of anti-tumor drug targets, and have attracted widespread attention from pharmacists in various countries. In previous research, a binding gap in the ATP-binding domain of the FGFR1 protein was discovered, and a novel FGFR1 inhibitor design idea was proposed for the spatial structure of the gap.. Structure Fibroblast growth factor receptors consist of extracellular ligand domains that bind to fibroblast growth factor, which is the largest member of the growth factor ligand family, including 22 members. The extracellular ligand domain consists of three ...

definition of FGFR1K, what does FGFR1K mean?, meaning of FGFR1K, Fibroblast Growth Factor Receptor 1 Kinase, FGFR1K stands for Fibroblast Growth Factor Receptor 1 Kinase

This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013 ...

Shop Fibroblast growth factor receptor ELISA Kit, Recombinant Protein and Fibroblast growth factor receptor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.

Although drugable fibroblast growth factor receptor (FGFR) alterations in squamous cell carcinomas (SCC) of various entities are well known, little is known about FGFR modifications in squamous differentiated bladder cancer. Therefore, our study evaluated FGFR1-3 alterations as a putative therapeutic target in this subgroup. We analyzed 73 squamous differentiated bladder cancers (n = 10 pT2, n = 55 pT3, n = 8 pT4) for FGFR1-3 protein expression, FGFR1-3 copy number variations, FGFR3 chromosomal rearrangements (fluorescence in situ hybridization (FISH)) and FGFR3 mutations (SNapShot analysis). Only single cases displayed enhanced protein expression, most frequently FGFR3 overexpression (9.4% (6/64)). FISH showed no amplifications of FGFR1, 2 or 3. Break apart events were only slightly above the cut off in 12.1% (8/66) of cases and no FGFR3-TACC3 rearrangements could be proven by qPCR. FGFR3 mutations (p.S249C) were found in 8.5% (6/71) of tumors and were significantly associated with FGFR3 ...

TY - JOUR. T1 - Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. AU - Lee, Ting Wei. AU - Lee, Ting I.. AU - Lin, Yung Kuo. AU - Kao, Yu Hsun. AU - Chen, Yi Jen. PY - 2018/5/18. Y1 - 2018/5/18. N2 - Background: Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Multiple laboratory findings indicate that calcitriol may be a potential treatment for CVDs. In this study, we attempted to investigate whether calcitriol regulates FGFR1 expression to modulate the effects of FGF-2 signaling in cardiac myocytes and explored the potential regulatory mechanism. Methods: Western blot, polymerase chain reaction, small interfering RNA, fluorometric activity assay, and chromatin immunoprecipitation (ChIP) analyses were used to evaluate FGFR1, FGFR2, FGFR3, FGFR4, phosphorylated ...

cansSAR 3D Structure of 6C1C | FGFR1 KINASE COMPLEX WITH INHIBITOR SN37116 | 6C1C_A | Fibroblast growth factor receptor 1 - Also known as FGFR1_HUMAN, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling

Progression of prostate cancer from an androgen sensitive to androgen insensitive tumor has previously been shown to be accompanied by a change in alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in a rat model of prostate cancer. This change results in loss of the FGF-R2(IIIb) i …

Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.. ...

Alternative initiations of translation of the human fibroblast growth factor 2 (FGF-2) mRNA, at three CUG start codons and one AUG start codon, result in the synthesis of four isoforms of FGF-2. This process has important consequences on the fate of FGF-2: the CUG-initiated products are nuclear and their constitutive expression is able to induce cell immortalization, whereas the AUG-initiated product, mostly cytoplasmic, can generate cell transformation. Thus, the different isoforms probably have distinct targets in the cell. We show here that translation initiation of the FGF-2 mRNA breaks the rule of the cap-dependent ribosome scanning mechanism. First, translation of the FGF-2 mRNA was shown to be cap independent in vitro. This cap-independent translation required a sequence located between nucleotides (nt) 192 and 256 from the 5 end of the 318-nt-long 5 untranslated region. Second, expression of bicistronic vectors in COS-7 cells indicated that the FGF-2 mRNA is translated through a ...

Recombinant Human Fibroblast growth factor 23 Protein. Synthesized in e. coli. Protein Tag: Untagged. Purity: Greater than 95% as determined by SDS-PAGE and HPLC. From $98

TY - JOUR. T1 - Expression pattern of fibroblast growth factor receptor 1 gene during chickeye development. AU - Ohuchi, H.. PY - 1993/1/1. Y1 - 1993/1/1. KW - FGF receptor. KW - chick embryo. KW - development. KW - eye. KW - in situ hybridization. UR - http://www.scopus.com/inward/record.url?scp=0027158708&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027158708&partnerID=8YFLogxK. M3 - Article. C2 - 8391203. AN - SCOPUS:0027158708. VL - 97. SP - 304. EP - 309. JO - Journal of Japanese Ophthalmological Society. JF - Journal of Japanese Ophthalmological Society. SN - 0029-0203. IS - 3. ER - ...

Purchase Recombinant Mouse Fibroblast growth factor receptor 2(Fgfr2). It is produced in in vitro E.coli expression system. High purity. Good price.

FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two distinct but emerging hot topics in FGF biology: its role in stromal cross-talk during cancer progression and the potential roles of FGFR signalling in the nucleus. These neglected areas are proving to be of great interest clinically and are intimately linked, at least in pancreatic cancer. The importance of the stroma in cancer is well accepted, both as a conduit/barrier for treatment and as a target in its own right. Nuclear receptors are less acknowledged as targets, largely due to ...

Protein target information for Chain A, Fibroblast growth factor receptor 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

House, Stacey; Weinheimer, Carla; Kovac, Attila; Ornitz, David, Endothelial-specific fibroblast growth factor receptor 1 and 2 deletion impairs vascular remodeling and recovery in an in vivo, closed-chest model of cardiac ischemia-reperfusion injury (2012). Conference Abstracts and Posters. Paper 17. http://digitalcommons.wustl.edu/em_conf/17. ...

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the CNS, stimulates proliferation of stem cells during prenatal and postnatal neurogenesis and participates in regulating cell-type ratios in many developing regions of the brain. Anomalies in FGFR1 signaling have been implicated in certain neuropsychiatric disorders. Fgfr1 expression has been shown, via in situ hybridization, to vary spatially and temporally throughout embryonic and postnatal development of the brain. However, in situ hybridization lacks sufficient resolution to identify which cell-types directly participate in FGF signaling. Furthermore, because antibodies raised against FGFR1 commonly cross-react with other members of the FGFR family, immunocytochemistry is not alone sufficient to accurately document Fgfr1 expression. Here, we

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the CNS, stimulates proliferation of stem cells during prenatal and postnatal neurogenesis and participates in regulating cell-type ratios in many developing regions of the brain. Anomalies in FGFR1 signaling have been implicated in certain neuropsychiatric disorders. Fgfr1 expression has been shown, via in situ hybridization, to vary spatially and temporally throughout embryonic and postnatal development of the brain. However, in situ hybridization lacks sufficient resolution to identify which cell-types directly participate in FGF signaling. Furthermore, because antibodies raised against FGFR1 commonly cross-react with other members of the FGFR family, immunocytochemistry is not alone sufficient to accurately document Fgfr1 expression. Here, we

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth ...

Fibroblast growth factors (FGFs) can influence the growth and differentiation of cultured cells derived from neuroectoderm, ectoderm or mesenchyme. The FGFs interact with a family of at least four closely related receptor tyrosine kinases that are products of individual genes. To investigate the role of FGFs in the growth and differentiation of embryonic tissues and to determine whether the individual FGF receptor genes might have specific functions, we compared the localization of mRNA for two FGF receptor genes, FGFR1 (the flg gene product) and FGFR2 (the bek gene product), during limb formation and organogenesis in mouse embryos (E9.5-E16.5). Although the two genes were coexpressed in some tissues, the differential expression of FGFR1 and FGFR2 in most embryonic tissues was striking. FGFR1 was expressed diffusely in mesenchyme of limb buds, somites and organ rudiments. In contrast, FGFR2 was expressed predominantly in the epithelial cells of embryonic skin and of developing organs. The ...

Recombinant protein of human fibroblast growth factor receptor 4 (FGFR4), transcript variant 2, 20 ug available for purchase from OriGene - Your Gene Company.

A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy. Unlike other tyrosine kinase receptors activated by N-terminal truncation in tumors, this receptor, FGFR2-ROS, contains an altered C terminus generated from chromosomal rearrangement with a novel gene, designated FGFR activating gene 1 (FRAG1). While the removal of the C terminus slightly activates FGFR2, the presence of the FRAG1 sequence drastically stimulates the transforming activity and autophosphorylation of the receptor. FGFR2-ROS is expressed as a unusually large protein and is highly phosphorylated in NIH 3T3 transfectants. FRAG1 is ubiquitously expressed and encodes a predicted protein of 28 kDa lacking significant structural similarity to known proteins. Epitope-tagged FRAG1 protein showed a perinuclear localization by immunofluorescence staining. The highly activated state of FGFR2-ROS appears to be attributed to constitutive dimer ...

AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.

Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development. To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach. First, we generated …

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4. Protein Tyrosine Kinase (PTK) family; Fibroblast Growth Factor Receptor 4 (FGFR4); catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FGFR4 is part of the FGFR subfamily, which are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of ...

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2. Protein Tyrosine Kinase (PTK) family; Fibroblast Growth Factor Receptor 2 (FGFR2); catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FGFR2 is part of the FGFR subfamily, which are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of ...

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As a promising target, FGFR4 is attracting intensive pharmaceutical and academic attention for developing novel target therapy against cancers driven by FGFR4

The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...

Das Netzwerk Genomische Medizin (NGM) Lungenkrebs wurde im März 2010 von der Kölner Lungenkrebsgruppe (Lung Cancer Group Cologne) gegründet, um zunächst in Nordrhein-Westfalen eine umfassende und qualitativ hochwertige molekulare Diagnostik für alle Patienten mit Lungenkrebs anzubieten und so die Implementierung personalisierter Therapie in der klinischen Routineversorgung zu fördern. Mittlerweile agiert das NGM bundesweit und strebt eine Flächendeckung in Deutschland an.. ...

Supplementary MaterialsSupplementary information. molecular identification capacity for aptamers as well as the superiority of Exos as organic vehicles, Apt-Exos can deliver molecular medications/fluorophores to focus on cancer tumor cells effectively, providing a appealing delivery system for cancers theranostics. Graphical Abstract Despite many developments in artificial delivery vehicles, their changeover from bench to bedside was hindered by low specificity still, high biotoxicity, and high immunogenicity.1 occurring vehicles Naturally, for example, exosomes (Exos), are anticipated to provide appealing alternatives for effective delivery of therapeutics/diagnostics.2 Exos are nanoscale membrane-enclosed vesicles (30C100 nm) secreted by various eukaryotic GDC0853 cells (e.g., spithelial cells and myeloid cells).3 They play critical assignments in cellCcell conversation through product packaging and transporting particular bioactive substances.4 In the modern times, pioneered with the Hardwood ...

Rep. 7, 46149; doi: 10.1038/srep46149 (2017). Publishers take note: Springer Character remains neutral in regards to to jurisdictional statements in published maps and institutional affiliations. Supplementary Material Supplementary Numbers:Just click here to see.(4.1M, pdf) Acknowledgments This research was backed from the Ministry of Science and Technology from the Republic Glycitein of China (give no. SKOV3 xenograft model without significant bodyweight loss. Collectively, our findings claim that MT-6 can be a powerful anticancer agent with tumor-suppressive activity and that may be further looked into for ovarian tumor therapy in the foreseeable future. Among malignant gynecological tumors, individuals with ovarian tumor have a higher mortality rate due to past due stage analysis1. Furthermore to debulking medical procedures, the typical treatment for ovarian tumor can be platinum-based chemotherapy in conjunction with taxane cytotoxic medicines, but most these patients relapse within 2 ...

For 21 of the 25 sequences, more information was obtainable and revealed that these were extracted from EBOV which were extensively passaged in cell lifestyle (= 19) or guinea pigs (= 1) or which were successively passaged in cell lifestyle, monkeys, and again cell lifestyle (= 1). and everything bat-derived cell lines examined was comparable. Furthermore, EBOV2014 replication in NHP however, not individual cells was reduced in accordance with EBOV1976, recommending that decreased cell admittance translated into decreased viral spread. Mutagenic evaluation of EBOV1976-GP and EBOV2014-GP uncovered an amino acidity polymorphism in the receptor-binding area, A82V, modulated admittance efficiency within a cell line-independent way and didnt take into account the decreased EBOV2014-GP-driven admittance into NHP cells. On the other hand, polymorphism T544I, situated in the inner fusion loop in the GP2 subunit, was discovered to lead to the admittance phenotype. These outcomes suggest that placement ...

Supplementary MaterialsSupporting Details. be used to create 3D tissue, which pays to for areas of tissues regeneration for medication advancement and regenerative medication. strong course=kwd-title Subject conditions: Assay systems, Regenerative medication, Tissue engineering Launch Organ features are preserved by vascular systems. For instance, the liver organ receives bloodstream from two huge vessels, the hepatic artery and website vein. Blood in… More →. ...

Product Name: Mouse mAb anti- human Fibroblast Growth Factor-basic (bFGF), Clone F-74Collection: AntibodySub Category: Monoclonal AntibodyImmunogen: Purified

CD334 / FGFR4 (fibroblast growth factor receptor 4), a transmembrane tyrosine kinase, which is expressed in many tissues, such as in lung, kidney, muscle, heart, pancreas, intestine and other, acts as a receptor for several fibroblast growth factors, namely FGF1, FGF2, FGF6, FGF8, and FGF19. Interaction with these growth factors initiates in cell the signaling cascades leading to the mitogenesis and cell differentiation. Presence of CD334 Gly338Arg allele correlates with prognostic parameters in various cancer studies. CD334 plays multiple roles in the organism, including those of muscle regeneration, cholesterol-to-bile acid metabolism, or glucose homeostasis ...

J:87411 Burns RC, Fairbanks TJ, Sala F, De Langhe S, Mailleux A, Thiery JP, Dickson C, Itoh N, Warburton D, Anderson KD, Bellusci S, Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev Biol. 2004 Jan 1;265(1):61-74 ...

The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression. Mol Cancer Res; 8(11); 1439-52. ©2010 AACR. ...

FGF8 - FGF8 (untagged)-Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant B available for purchase from OriGene - Your Gene Company.

Recombinant human FGFR4 (460-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. FGFR4 is a member of the fibroblast growth factor receptor family, which play a role in mitogenesis and differentiation.

J:1618 Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P, Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development. 1991 Dec;113(4):1419-34 ...

FRS3 (Fibroblast Growth Factor Receptor Substrate 3, FGFR Substrate 3, FGFR-signaling Adaptor SNT2 Suc1-associated Neurotrophic Factor Target 2, SNT-2, SNT2 ...

FGFR2 antibody (fibroblast growth factor receptor 2) for ICC/IF, IHC-P, WB. Anti-FGFR2 pAb (GTX55622) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.

FGFR2 antibody (fibroblast growth factor receptor 2) for FACS, ICC/IF, IHC-P, WB. Anti-FGFR2 pAb (GTX25476) is tested in Human, Mouse samples. 100% Ab-Assurance.

Looking for online definition of fibroblast growth factor receptor gene in the Medical Dictionary? fibroblast growth factor receptor gene explanation free. What is fibroblast growth factor receptor gene? Meaning of fibroblast growth factor receptor gene medical term. What does fibroblast growth factor receptor gene mean?

TY - JOUR. T1 - Fibroblast Growth Factor Receptor-3 Is Expressed in Undifferentiated Intestinal Epithelial Cells during Murine Crypt Morphogenesis. AU - Vidrich, Alda. AU - Buzan, Jenny M.. AU - Ilo, Chibuzo. AU - Bradley, Leigh. AU - Skaar, Kirstin. AU - Cohn, Steven. PY - 2004/5/1. Y1 - 2004/5/1. N2 - Prior studies have demonstrated that fibroblast growth factor receptor-3 (FGFR-3) regulates proliferation of undifferentiated intestinal epithelial cells in vitro. However, the function(s) of FGFR-3-mediated signaling during intestinal development and epithelial differentiation in vivo remain unknown. The goal of this study was to define the temporal, regional, and cell-specific patterns of FGFR-3 expression and its ligands during normal intestinal ontogeny and epithelial regeneration. Both the IIIb and IIIc isoforms of FGFR-3 mRNA, which result from differential splicing of the FGFR-3 primary transcript, were detected in mouse small intestine as early as embryonic day 16. FGFR-3 levels peaked in ...

TY - JOUR. T1 - Evaluation of the tumorigenic and angiogenic potential of human fibroblast growth factor FGF3 in nude mice. AU - Li, J. J.. AU - Friedman-Kien, A. E.. AU - Cockerell, C.. AU - Nicolaides, A.. AU - Liang, S. L.. AU - Huang, Y. Q.. PY - 1998/6/13. Y1 - 1998/6/13. N2 - Recently, the expression of fibroblast growth factor 3 (FGF3) was found in 55% of human Kaposis sarcoma (KS) tumor tissues examined, while almost no expression of FGF3 was found in normal skin. To further these studies, human FGF3 cDNA were constructed by the overlap-extension method. The proteins translated from two FGF3 cDNA, which differ only in the sequences preceding the AUG presumed to be the initiation codon, were shown to have the same molecular mass. This result suggests that translation of human FGF3, which is different from mouse FGF3, begins only at the AUG site. The human FGF cDNA was transfected into NIH3T3 cells. The NIH 3T3 cells transformed by FGF3 were then injected subcutaneously into athymic nude ...

TY - JOUR. T1 - Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. AU - Oltean, Sebastian. AU - Sorg, Brian. AU - Albrecht, Todd. AU - Bonano, Vivian. AU - Brazas, Rob. AU - Dewhirst, Mark. AU - Garcia-Blanco, Mariano. PY - 2006. Y1 - 2006. M3 - Article (Academic Journal). JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424. ER - ...

Search and download thousands of Swedish university dissertations (essays). Full text. Free. Dissertation: Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea.

negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway - Ontology Report - Rat Genome Database

TY - THES. T1 - Fibroblast growth factor receptor 1 signaling in the early development of the midbrain-hindbrain and pharyngeal region. AU - Trokovic, Ras. PY - 2005. Y1 - 2005. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. M3 - Doctoral Thesis. SN - 952-10-2296-5. T3 - Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki. PB - University of Helsinki. CY - Helsinki. ER - ...

Antibodies for proteins involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development pathways, according to their Panther/Gene Ontology Classification

Growth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair. © 2006 Elsevier B.V. All rights reserved ...

Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes. Biological effects mediated by FGF-2 include inhibition of proteoglycan production, up-regulation of matrix metalloproteinase-13 (MMP-13), and stimulation of other catabolic factors. In this study, we identified the specific receptor responsible for the catabolic functions of FGF-2, and established a pathophysiological connection between the FGF-2 receptor and OA. Primary human articular chondrocytes were cultured in monolayer (24 hours) or alginate beads (21 days), and stimulated with FGF-2 or FGF18, in the presence or absence of FGFR1 (FGF receptor 1) inhibitor. Proteoglycan accumulation and chondrocyte proliferation were assessed by dimethylmethylene blue (DMMB) assay and DNA assay, respectively. Expression of FGFRs (FGFR1 to FGFR4) was assessed by flow cytometry,

Clone REA1243 recognizes the human CD334 (FGFR4) antigen, known as Fibroblast growth factor receptor 4, which is a member of the fibroblast growth factor receptor family. This cell surface tyrosine kinase is a high affinity receptor for both acidic and basic fibroblast growth factor. The binding of CD334 with the acidic fibroblast growth factors FGF2, FGF6, and FGF8, FGF19 and GFG1 induces mitogenesis and differentiation. CD334 is expressed in adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues of human fetuses. A soluble-form splice variant of FGFR 4 was identified in human gastrointestinal epithelial cells and cancer cells.Additional information: Clone REA1243 displays negligible binding to Fc receptors. - Ireland

ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice variant affects the function of ADAM15. Here, we show that ADAM15B has enhanced catalytic activity in cell-based assays compared with ADAM15A, which lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an assay for catalytic activity. Moreover, the enhanced activity of ADAM15B compared with ADAM15A depends on Src because it is abolished by Src-kinase inhibitors and in Src(-/-) cells, but not in Src(-/-) cells rescued with Src. These findings provide insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B, and suggest that inhibitors of the ADAM15 protease activity or of the

Rapid appearance of resistance to fibroblast growth factor receptor (FGFR) inhibitors hampers targeted regimens in bladder cancer. In the present study, we evaluated whether SIP-SII, a sulphated derivative of the polysaccharide in Sepiella maindroni (spineless cuttlefish) ink used in traditional Chinese medicine, could attenuate resistance to FGFR inhibition in bladder cancer cells. In vitro assays indicated that SIP-SII reduced cell viability and migration, restricted cell cycle progression, and increased apoptosis in parallel with decreased AKT phosphorylation and downregulation of CDK4, MMP2, and Bcl-2 in RT112 and JMSU1 cells. Synergistic effects on cell viability were observed when SIP-SII was combined with the small-molecule FGFR inhibitor AZD4547. Specific Akt targeting by SIP-SII was suggested by the fact that neither Akt knockdown nor the selective PI3K inhibitor BKM120 enhanced the inhibitory effects of SIP-II, while expression of a constitutively active Akt mutant rescued SIP-SII

Recombinant Fibroblast Growth Factor 13 (FGF13) Protein. Species: Human. Source: Escherichia coli (E. coli). Order product ABIN6304346.

Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics. Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21. A single injection of R1MAb into obese diabetic mice induced acute and sustained amelioration of hyperglycemia, along with marked improvement in hyperinsulinemia, hyperlipidemia, and hepatosteatosis. R1MAb activated the mitogen-activated protein kinase pathway in adipose tissues, but not in liver, and neither FGF21 nor R1MAb improved glucose clearance in lipoatrophic mice, which suggests that adipose tissues played a central role in the observed metabolic effects. In brown adipose tissues, both FGF21 and R1MAb induced phosphorylation of CREB (cyclic adenosine 5′-monophosphate response ...

The FGFR3 receptor tyrosine kinase represents an attractive target for therapy due to its role in several human disorders, including skeletal dysplasias, multiple myeloma, and cervical and bladder carcinomas. By using molecular library screening, we identified a compound named NF449 with inhibitory activity toward FGFR3 signaling. In cultured chondrocytes and murine limb organ culture, NF449 rescued FGFR3-mediated extracellular matrix loss and growth inhibition, which represent two major cellular phenotypes of aberrant FGFR3 signaling in cartilage. Similarly, NF449 antagonized FGFR3 action in the multiple myeloma cell lines OPM2 and KMS11. In cell-free kinase assays, NF449 inhibited the kinase activity of both wild type and a disease-associated FGFR3 mutant (K650E) in a fashion that appeared non-competitive with ATP ...

Lab Rotation Projects Areas of interest; Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, (produced by osteoblasts, osteoclasts and stromal cells) regulate bone development, remodeling and disorders of bone. Project 1- Fgf2 knockout and Fgf2 transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone including osteoporosis. Project 2- Examination of the effects of cytokines and hormones including interleukin-1 (IL-1), parathyroid hormone (PTH), insulin-like growth factor-I (IGF-I), transforming growth factor beta (TGF?), prostaglandins (PGs) and glucocorticoids on FGF2 and FGFR signaling, gene transcription, mRNA stability and the activity of transfected Fgf2 promoter-luciferase reporter gene constructs.. ...

We sought to describe corneal epithelial changes after using epidermal (EGFR) or fibroblast growth factor receptor (FGFR) inhibitors as chemotherapy and to clarify incidence and prognosis. Retrospective chart review. Among 6871 patients and 17 EGFR or FGFR inhibitors, 1161 patients (16.9%) referred for ophthalmologic examination. In total, 1145 patients had disease-related or unrelated ocular complications. Among 16 patients with treatment-related ocular complications, three patients had treatment-related radiation retinopathy and one patient showed treatment-related corneal ulcer. Finally the authors identified that, in 12 patients, three EGFR inhibitors and two FGFR inhibitors caused corneal epithelial lesions. Vandetanib, Osimertinib, and ABT-414 caused vortex keratopathy in nine patients, while ASP-5878 and FPA-144 caused epithelial changes resembling corneal dysmaturation in three patients. The mean interval until symptoms appeared was 246 days with vandetanib, 196 days with osimertinib, 30 days

The mouse thymic primordium is formed around E10.5 as an epithelial bud from the third pharyngeal pouch and mesenchyme that differentiates from neural crest cells (1, 2, 3). At about E11.5, the epithelial primordium is first colonized by T cell progenitors that migrate in from blood vessels in the surrounding mesenchyme. At E12, the mesenchyme surrounds, but has not penetrated, the epithelium. Removal of the mesenchyme at this critical phase prevented the development of the epithelium in vitro (36). Subsequently, Shinohara and Honjo showed that the mesenchyme of the early E12 thymus influences MHC class II expression in the epithelium, but they did not study the effects on lymphopoiesis (37, 38). At E12, thymic explants show a limited lymphoid developmental capacity, which can be enhanced by addition of fibroblasts (39, 40).. In a recent study, E12 thymic lobes with intact mesenchyme were shown to generate all T cell populations in vitro, but lobes from which mesenchyme has been removed show ...

Soluble FGFR-1a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric.

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We examined the localization of basic fibroblast growth factor (bFGF) in the developing embryonic and newborn rat nervous system using 2 anti-bFGF antibodies. Embryonic (E13, E14, E15, E16, E17, and E18) and newborn tissues were examined. Between E16 and E17 strong bFGF immunoreactivity (IR) was det...

Aberrant signaling through Fibroblast Growth Factor Receptors (FGFR) has been reported in multiple types of human cancers. FGFR4 signaling contributes to the development and progression of subsets of cancer: in approximately 10 percent of hepatocellular carcinoma (HCC), genetic amplification of FGF19, encoding an endocrine FGF ligand that activates FGFR4-KLB receptors, has been reported. In models with this alteration, FGF19-FGFR4 signaling is oncogenic and antagonism of the FGF19-FGFR4 axis has been shown to be efficacious suggesting that selective targeting of FGFR4 may be an effective strategy for malignancies with FGFR4 activation.. We describe the preclinical characterization of INCB062079 a potent and selective inhibitor of the FGFR4 kinase. In biochemical assays INCB062079 inhibited FGFR4 with low nM potency and exhibited at least 250-fold selectivity against other FGFR kinases and greater than 800-fold selectivity against a large kinase panel. This selectivity derives from the ability of ...

Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder- stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed. ...

PD 161570 | FGFR inhibitor | PD161570 | CAS [192705-80-9] | Axon 2098 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research

Deregulated FGFR expression plays an important role in driving many cancers. In this report, Zhang and colleagues identify FGFR1 gene amplification in a cohort of Chinese squamous cell carcinoma, in which effective treatment therapies are desperately needed. Utility for the novel and selective FGFR inhibitor, AZD4547, was shown through in vitro tumor cell proliferation studies, and importantly, translational significance was established by the observation of tumor stasis or regression effects in a panel of FGFR1-amplified squamous lung patient-derived tumor xenograft models, but not in nonamplified models. These data thus provide a strong rationale for the investigation of AZD4547 as a novel therapeutic option for NSCLC patients with tumors harboring FGFR1 amplification.. ...

Our present data indicate that (a) FGF-induced Erk1/2 activation is required for Ets activation, (b) subsequent Ets binding to the FOX:ETS motif in the first intron enhancer of the Vegfr2 gene plays an important role in VEGFR2 expression, and (c) this FGF regulation of VEGFR2 expression plays a critical role in adult neovascularization and vascular integrity (Figure 6E). Early observation pointed to critical interplay and synergism of FGF and VEGF systems in angiogenic assays, with a combination of VEGF and FGF2 inducing a far stronger in vitro angiogenic response than either growth factor by itself (21). This was thought to be due to an induction of VEGFR2 expression by FGF2 while VEGF induction of FGFR expression was not seen (22). This has been attributed to the involvement of Erk and PKC signaling, but not yet been demonstrated (23). Our data demonstrate, for the first time to our knowledge, that Erk1/2 activation is critical for FGF-dependent regulation of VEGFR2 expression. Moreover, our ...

fibroblast growth factor receptor-4 FGFR4 contains rs351855 which is likely to cause a hard to treat version of breast cancer. ...

fibroblast growth factor receptor-4 FGFR4 contains rs351855 which is likely to cause a hard to treat version of breast cancer. ...

Complete information for FGFR3P4 gene (Pseudogene), Fibroblast Growth Factor Receptor 3 Pseudogene 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in a broad range of cancers and occur in ~20% of ICCs. As seen with other targeted therapies, however, acquired resistance has limited the efficacy of selective FGFR kinase inhibitors such as BGJ398. In a phase II trial of patients with advanced refractory cholangiocarcinoma harboring an FGFR gene alteration, BGJ398 displayed an overall response rate of 22%, but the durability of response was short in some patients. We report the molecular basis of acquired resistance in 4 patients with advanced FGFR2-fusion positive ICC via integrative genomic characterization of cell-free circulating tumor DNA (cfDNA), the primary tumor, and metastases. Each patient enjoyed an initial response, but all subsequently progressed within 10 months. Serial analysis of cfDNA revealed multiple point mutations in the FGFR2 kinase domain at progression (Table 1). The gatekeeper mutation, p. V564F, sterically ...

Cellular signaling via EGFR is initiated by ligand-stimulated autophosphorylation of key tyrosine residues of EGFR that have been shown to recruit a host of downstream signaling proteins leading to activation of various cellular pathways responsible for controlling growth and survival (28). Our previous study with FGFR1 (fibroblast growth factor receptor 1) have shown that the order of autophosphorylation is important in providing both temporal and spatial resolutions to receptor signaling and this order is perturbed in an oncogenic form of FGFR1 (29, 30). Therefore, the pattern and timing of phosphorylation events on EGFR may be important for proper orchestration of downstream partner recruitment and activation of relevant pathways in a defined manner for appropriate regulation of cell growth. Identifying specific phosphosignatures of global EGFR signaling may offer insights that may be useful for predicting patient response to EGFR-targeted therapy as well as combination treatments. Our ...

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In this study, we report that high FGFR1 protein expression is a prognostic biomarker in HPV-negative HNSCC. Furthermore, the frequent overexpression of FGFR1 in HNSCC provides a rationale to test FGFR inhibitors in clinical trials. Here, we demonstrated that combined EGFR/FGFR inhibitor treatment can be used to treat FGFR inhibitor-resistant HNSCC.. Our finding that 82% of HPV-positive and 75% of HPV-negative HNSCC overexpress FGFR1 is in concordance with previous reports, but it differs from a study by Freier and colleagues, which reported high FGFR1 expression in only 12% of OSCC (5, 17, 31, 32). In addition, we observed prognostic value for FGFR1 protein expression in HPV-negative HNSCC, which has not been reported by previous studies, although Hase and colleagues reported prognostic value for FGFR1 expression in oral cancer-associated fibroblast (32, 33). These contradictions might be explained by differences in anti-FGFR1 antibodies to determine protein expression or study populations. ...

Verzeichniss bekannter Schmettlinge, 1816-[1826] Verz. bek. Schmett. (1): [1-3], 4-16 (1816), (2): 17-32 (1819), (3): 33-48 (1819), (4): 49-64 (1819), (5): 65-80 (1819), (6): 81-96 (1819), (7): 97-112 (1819), (8): 113-128 (1819), (9): 129-144 (1819), (10): 145-160 (1819), (11): 161-176 (1819), (12): 177-192 (1820), (13): 193-208 (1820), (14): 209-224 (1821), (15): 225-240 (1821), (16): 241-256 (1821), (17): 257-272 (1823), (18): 273-288 (1823), (19): 289-304 (1823), (20): 305-320 (1825), (21): 321-336 (1825), (22): 337-352 (1825), (23-27): 353-431 ([1825 ...