Domain Eukarya Kingdom Plantae Division Magnoliophyta Class Magnoliopsida Order Rosales Family Rosaceae Subfamily Maloideae Genus Malus Red, yellow, gre...

The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact with c-KIT and suppress c-KIT-dependent pathways. Here, we analyzed the molecular mechanisms that determine SOCS6 substrate recognition. Our results show that the SH2 domain of SOCS6 is essential for its interaction with c-KIT pY568. The 1.45-Å crystal structure of SOCS6 SH2 domain bound to the c-KIT substrate peptide (c-KIT residues 564-574) revealed a highly complementary and specific interface giving rise to a high affinity interaction (K(d) = 0.3 μm). Interestingly, the SH2 binding pocket extends to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that

c-キット阻害剤（経路に合図することの標的を妨げる）がいろいろな分析のために使われて、いくつかは臨床試験に入りました。そして、それは新しいガン療法です。

Rabbit polyclonal c-Kit (phospho Y823) antibody validated for WB and tested in Human. Immunogen corresponding to synthetic peptide

387558135 - EP 1127577 A3 2002-11-27 - Ligand for the c-kit receptor and methods of use thereof - [origin: US6159461A] Compositions comprising c-kit ligand, TNF- alpha , and a hematopoietic factor are useful to promote the expansion of peripheral blood cells or the expansion and differentiation of hematopoietic progenitor cells.[origin: US6159461A] Compositions comprising c-kit ligand, TNF- alpha , and a hematopoietic factor are useful to promote the expansion of peripheral blood cells or the expansion and differentiation of hematopoietic progenitor cells.

c-Kit immuno EM pictures showing c-Kit+ ICC in wild-type proximal colon and c-Kit- FL-ICC in Ws/Ws mid colon. (a) A c-Kit+ ICC-AP (ICC, dark stained with DAB)

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c-Kit (phospho Tyr721) antibody (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) for WB. Anti-c-Kit (phospho Tyr721) pAb (GTX79105) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.

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Previous immunohistochemical studies targeting the receptor tyrosine kinase (c-Kit) have demonstrated an apparent reduction in the number of gastrointestinal pacemaker cells--the interstitial cells of Cajal (ICC)--in horses with intestinal motility disorders. This study compared the level of transcription of the c-kit gene encoding this receptor in horses with and without such motility disorders. Transcription levels of this gene were also compared to the density of ICC immunohistochemically positive for the c-Kit antigen. Intestinal samples were collected from 18 horses with intestinal disease and from 15 control animals. Following gene extraction and identification, real-time quantitative analysis of c-kit and a control gene, ACTB (β-actin), was carried out on all samples and the density of the c-Kit-positive ICC compared. There was a significant reduction in c-Kit immunoreactivity in the ICC of horses with large intestinal obstructive disorders relative to controls but no significant ...

Alternative Name. KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; PBT; C-Kit;. ...

TY - JOUR. T1 - Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. AU - Hisakawa, Hiroaki. AU - Sugiyama, Daisuke. AU - Nishijima, Ichiko. AU - Xu, Ming Jiang. AU - Wu, Hong. AU - Nakao, Kazuki. AU - Watanabe, Sumiko. AU - Katsuki, Motoya. AU - Asano, Shigetaka. AU - Aral, Ken Ichi. AU - Nakahata, Tatsutoshi. AU - Tsuji, Kohichiro. PY - 2001/12/15. Y1 - 2001/12/15. N2 - Although erythropoietin (EPO) and its receptor (EPOR) are crucial for the proliferation, survival, and terminal differentiation of erythroid progenitors, it remains to be elucidated whether EPOR-unique signaling is required for erythropoiesis. To address this issue, human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor (hGMR)-transgenic mice and heterozygous EPOR mutant mice were crossed by in vitro fertilization. In methylcellulose clonal culture of fetal liver (FL) ...

Hardware RAID delivers added speed and stability. The specially-designed solution runs the operating system from an SSD drive of its own, which frees the HDD array for user data. Hardware RAID enables the WSH5610DN to deliver outstanding performance unaffected by heavy load operations, even during RAID rebuilding.. The WSH5610DNS2 is installed with Windows Storage Server 2012 R2 Standard Edition. It seamlessly integrates with Windows computers and servers on existing networks and facilitates quick, straightforward deployment with massive storage capacity available in an instant.. ...