This is a specific mechanism. the Endocytosis is stimulated by binding of specific molecules to their specific membrane receptors. A pocket is formed, then pinced off, bilayer fuses, then incoming molecule is taken into the cell. ATP is used ...
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The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.. ...
Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking me
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Though zebrafish do not have placental arterioles and mice do not have a structural equivalent to the PAV, our developmental studies indicate that netrin signaling has evolved to ensure the formation of specific subsets of vessels. Thus, in contrast to VEGF signaling, which has profound effects on virtually all endothelial cells and vascular beds during developmental angiogenesis (Ferrara et al., 2003), guidance cues in general and UNC5B specifically, may provide an additional level of regulation to coordinate the spatial and temporal organization of tissue-specific vascular beds during embryogenesis. Because the first vital requirement for UNC5B is during mid-gestation, the reagents used in this study were unable to ascertain a function in later stages of development or within the adult. Such an assessment requires the use of alternative mutagenesis schemes, which we are vigorously pursuing.. A role for UNC5B in embryonic angiogenesis was originally postulated because of its vascular-specific ...
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Interpretive Summary: The acquisition of nutrients and the avoidance of toxicants by plants is an important problem in agricultural production and human health. The bioavailability of nutrients and toxicants is determined by plant characteristics and by the environment. For example, copper, both a nutrient and a toxicant, and lead, a toxicant, are accumulated in some plants more than in others, and in hard waters (high concentration of calcium and magnesium) these metals are much less available (and less intoxicating) than in soft waters. Toxicologists have adopted the Biotic Ligand Model (BLM) to interpret and predict toxicant bioavailability. The model states that ameliorative ions (e.g., Ca and Mg) alleviate toxicity by competing with toxicants (e.g., Cu and Pb) for cell-surface binding site. The BLM is only a partial explanation and it ignores the great importance of cell electrical phenomena. The contribution of the present study is the extension of our understanding of plant and ...
Eezi-Awn K9 Roof Rack to suit Suzuki Jimny, 1.2m long, Track mount.. Dolium practically pioneered flat-deck roof racks in Australia, and now theyve made a good thing even better with the introduction of the next generation in flat-decks - the K9 Rack.. A true expedition-strength roof rack, the K9 Rack employs a fully-welded Aluminium deck with cross-braced longitudinal slats for greater support and carrying capacity.. Built around aero-section Aluminium extrusions, and with built-in harmonic damping thanks to the cross-bracing, the longitudinal front-to-back slat arrangement significantly reduces noise and drag.. Each slat incorporates twin slots which accept movable bolts giving the K9 Rack far greater mounting versatility than other flat-deck racks - itll even accept most other brands accessories.. The K9 Rack isnt just stronger and quieter than other flat-deck racks - its also lower. With low-profile aero section extrusions and a close-fitting mounting system, K9 Rack gives you more ...
Endoglin is a coreceptor for transforming growth factor-β (TGF-β) that acts as a suppressor of malignancy during mouse skin… Expand ...
TY - JOUR. T1 - Urokinase-type plasminogen activator receptor is involved in mediating the apoptotic effect of cleaved high molecular weight kininogen in human endothelial cells. AU - Cao, Dian J.. AU - Guo, Yan Lin. AU - Colman, Robert W.. PY - 2004/5/14. Y1 - 2004/5/14. N2 - Cleaved high molecular weight kininogen (HKa) has been shown to inhibit in vivo neovascularization and induce apoptosis of endothelial cells. We have shown that HKa-induced apoptosis correlated with its antiadhesive effect and was regulated by extracellular matrix (ECM) proteins. In this study, we identified the urokinase-type plasminogen activator receptor (uPAR) as a target of HKa activity at the endothelial cell surface. Anti-uPAR antibodies blocked the apoptotic effect of HKa. Further studies revealed that uPAR formed a signaling complex containing integrin αvβ3 or α5β1, caveolin, and Src kinase Yes in endothelial cells. HKa physically disrupted the formation of this complex in a manner that paralleled its ...
A circulating biomarker of early pregnancy outcome independent of ultrasonography and gestational age is a coveted goal. This study evaluated soluble urokinase plasminogen activator receptor (suPAR), a well-described marker of inflammation and immunological activation, for this purpose, and compared it with established early pregnancy biomarkers of the luteoplacental phase: progesterone, estradiol and hCG. We merged data from two prospective first trimester cohorts to conduct a case-control study comparing these analytes in women who had either a live birth, a miscarriage or an ectopic pregnancy. The ability to predict pregnancy location and viability was assessed by areas under the receiver operating characteristic curves (AUC). Comparing women irrespective of gestational age with a live birth, miscarriage or ectopic pregnancy showed significantly lower suPAR values in the latter group (2.4 vs. 2.4 vs. 2.0 μg/L, p = 0.032, respectively), as were all other analytes. Before 6 weeks gestation, ...
Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis.
Dive into the research topics of Soluble urokinase-type plasminogen activator receptor, changes of 24-hour blood pressure, and progression of chronic kidney disease. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Expression of a folate binding protein in L1210 cells grown in low folate medium. AU - Jansen, G. AU - Kathmann, I. AU - Rademaker, B C. AU - Braakhuis, B J. AU - Westerhof, G R. AU - Rijksen, G. AU - Schornagel, J H. PY - 1989/4/15. Y1 - 1989/4/15. N2 - We have isolated variants of L1210 cells (L1210B) expressing, in addition to the classical high affinity/low capacity system for reduced folate uptake, high levels of a membrane-associated folate binding protein. This folate binding protein was expressed in L1210 cells grown at low physiological folate levels (less than 0.5 nM), but down-regulated after transfer in standard high folate (2 microM) medium. The binding capacity of L1210B cells for [3H]folic acid and [3H]-methotrexate was identical (5-11 pmol/10(6) cells) but affinities were different. The affinities relative to folic acid were 0.5 for 5-methyltetrahydrofolate, 0.25 for 5-formyltetrahydrofolate, 0.08 for 10-ethyl-10-deazaaminopterin, and 0.05 for methotrexate, ...
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (pressure H and Con1) are infectious for the human hepatoma cell traces Huh-7 and PLC/PR5. Infectivity will depend on coexpression of each E1 and E2 glycoproteins, is pH-dependent, and could be neutralized by mAbs mapping to amino acids 412-447 inside E2. Cell-surface expression of 1 or all the candidate receptor molecules (CD81, low-density lipoprotein receptor, scavenger receptor class B sort 1, and dendritic cell-specific intercellular adhesion molecule three grabbing nonintegrin) didnt confer permissivity to HIV-HCV pseudotype an infection. Nonetheless, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble type of CD81 and a mAb particular for CD81, suggesting that CD81 could…. ...
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (pressure H and Con1) are infectious for the human hepatoma cell traces Huh-7 and PLC/PR5. Infectivity will depend on coexpression of each E1 and E2 glycoproteins, is pH-dependent, and could be neutralized by mAbs mapping to amino acids 412-447 inside E2. Cell-surface expression of 1 or all the candidate receptor molecules (CD81, low-density lipoprotein receptor, scavenger receptor class B sort 1, and dendritic cell-specific intercellular adhesion molecule three grabbing nonintegrin) didnt confer permissivity to HIV-HCV pseudotype an infection. Nonetheless, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble type of CD81 and a mAb particular for CD81, suggesting that CD81 could…. ...
The Eagle Biosciences Soluble Leptin Receptor (sLEP-R) ELISA Assay Kit is for measurement of soluble human leptin receptor (sLEP-R) in human serum or plasma
Signaling lymphocytic activation molecule (SLAM)-linked protein (SAP) plays an essential role in the immune Ezatiostat system mediating the function of several members of the SLAM family (SLAMF) of receptors whose expression is essential for T NK and B-cell Rabbit Polyclonal to GABRD. responses. in mouse. However it is definitely less obvious whether other users of this family may also participate in the development of these innate T cells. Here we display that and strain suggesting that Slamf5 may function as a negative regulator of innate CD8+ T cell development. Accordingly B6 mice showed an exclusive growth of innate CD8+ T cells but not NKT cells. Interestingly the SAP-independent strain showed an growth of both splenic innate CD8+ T cells and thymic NKT cells. On the other hand and similar to what was recently demonstrated in BALB/c mice the proportions of thymic promyelocytic leukemia zinc finger (PLZFhi) NKT cells and innate CD8+ T cells significantly improved in the SAP-independent ...
suPAR is a novel biomarker of inflammation, and it has been shown that suPAR is expressed in carotid plaque.10 In this study, we showed that elevated levels of suPAR were significantly associated with an increased risk of both CAD and ischemic stroke. Plasma levels of suPAR were increased in subjects with carotid plaque, and presence of both carotid plaque and elevated suPAR levels substantially increased risk of ischemic stroke and CAD.. Previous studies have shown that elevated levels of suPAR are related to increased risk of CVD.8,9 Our results are in accordance with a previous study that showed that suPAR in plasma was associated with carotid plaque and that subjects with elevated levels of suPAR had an increased risk of CVD.21 In a prospective study of 2315 healthy individuals, elevated suPAR, in combination with elevated hsCRP, improved the risk prediction beyond the Framingham risk score.22 To our knowledge, there are no studies that have explored the relationship with ischemic ...
Results Full-length uPAR expression was significantly downregulated in SSc dermis, especially in fibroblasts and endothelial cells. Dermal thickness, collagen content and myofibroblast counts were significantly greater in uPAR−/− than in uPAR+/+ mice. In uPAR−/− mice, dermal fibrosis was paralleled by endothelial cell apoptosis and severe loss of microvessels. Lungs from uPAR−/− mice displayed non-specific interstitial pneumonia-like pathological features, both with inflammation and collagen deposition. Pulmonary pathology worsened significantly from 12 to 24 weeks, as shown by a significant increase in alveolar septal width and collagen content.. ...
Previous experiments indicated that secreted (s) and membrane (m) forms of folate binding protein (FBP) are present in the intrauterine environment of the pig. Our previous studies indicated that the two forms were produced sequentially; the secreted form was present in the intrauterine glands until Day 20 of gestation, whereas binding analysis indicated that folate binding increased dramatically in placental membranes until Day 50 of gestation. However, the cell types expressing mFBP have not been investigated. In this experiment, uterine wall sections from Day 20, 35, 50, 70, 90, and 105 of gestation were collected at slaughter and fixed, and subjected to in situ hybridization analysis for mFBP expression. The mFBP mRNAwas expressed by both columnar and cuboidal epithelia of the placental folds and expression appeared to be similar throughout gestation. Therefore, the placenta expressed mFBP from Day 35 of gestation onward, consistent with the concept that sFBP and mFBP occur sequentially during
article{25b1f445-f908-4d68-b75c-46e879dc6bc1, abstract = {volved in tumor growth and metastasis. We assayed the components of the uPA system in homogenates of 64 primary epithelial ovarian tumors and 5 metastases and evaluated the association of these parameters to prognosis in the 51 malignant cases. The levels of uPA, PAI-2 and the uPA: PAI-I complex increased with progressive loss of histological differentiation (P-trend <0.001, <0.05 and <0.001). The level of PAI-I was higher in poorly than in well/moderately differentiated tumors (p = 0.03). The content of uPAR was lower in benign tumors as compared to borderline malignancies (p = 0.002), invasive primary tumors (p < 0.001), and metastases (p = 0.002). Surprisingly, the level of uPAR was lower in poorly differentiated as compared to both borderline (p = 0.01) and well differentiated malignant tumors (p = 0.005). Also, the level of uPAR was lower in advanced as compared to early stages of the disease (P-trend = 0.002). The median ...
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013 ...
Folate Binding Protein小鼠单克隆抗体[LK26](ab3361)可与人样本反应并经WB, IP, IHC, Flow Cyt, ICC/IF实验严格验证,被9篇文献引用并得到1个独立的用户反馈。
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity ...
Unequivocal identification of stem cells requires their separation and purification, usually based on a combination of specific cell-surface markers. These isolated stem cells [e.g., hematopoietic stem (HS) cells] can be studied in detail and used in clinical applications, such as bone marrow transplantation (Chap. 66). However, the lack of specific cell-surface markers for other types of stem cells has made it difficult to isolate them in large quantities. This challenge has been partially addressed in animal models by genetically marking different cell types with green-fluorescence protein driven by cell-specific promoters. Alternatively, putative stem cells have been isolated from a variety of tissues as side population (SP) cells using fluorescence-activated cell sorting after staining with Hoechst 33342 dye. ...
Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system. We reviewed the usefulness of systemic levels of s
Mouse uPA Receptor/U-PAR ELISA Kit is a sensitive (| 5 pg/ml) immunoassay suitable for the quantification of uPA Receptor/U-PAR in Cell culture supernatant, Serum, Cell Lysate, Hep Plasma, EDTA…
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers
Buy our Human DC-SIGN peptide. Ab6092 is a blocking peptide for ab5716 and has been validated in BL. Abcam provides free protocols, tips and expert support for…
Solid phase sandwich ELISA for the determination of soluble (Pro)renin receptor in human serum, EDTA-plasma, and urine. This kit can also be used for the determination of soluble (Pro)renin receptor in mouse and rat serum, EDTA-plasma, and cell culture.
The fundamental principles of signalling can be illustrated by a simple example in the yeast S. cerevisiae (Figure 1). In order to sexually reproduce, a yeast cell needs to be able to make physical contact with another yeast cell. First, it has to call to yeast cells of the opposite mating type. It does this by secreting a mating factor peptide, an extracellular signal, which can also be called an intercellular signal. Yeast mating factor binds to specific cell surface receptors on cells of the opposite mating type, and the signal is relayed into the target cell via a chain of interacting intracellular signalling molecules, which switch from an inactive (Figure 2a) to an active state (Figure 2b). Signalling molecules are said to be upstream or downstream of other components of the pathway (this terminology should not be confused with that used to describe the structure of genes in relation to transcription). Ultimately, signalling molecules activate target effector proteins (an effector in ...
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Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is composed of two distinct genes, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28. IL-27 is expressed by antigen presenting cells and interacts with a specific cell-surface receptor complex known as IL-27 receptor (IL-27R). This receptor consists of two proteins, IL-27ɑ and gp130. IL-27 induces differentiation of the diverse populations of T cells in the immune system and also upregulates IL-10. When IL-27 binds to the IL-27 receptor, signaling pathways including JAK-STAT and p38 MAPK pathways are turned on. There are two types of responses, pro-inflammatory and anti-inflammatory, which involve different types of cells, such as macrophages, dendritic cells, T cells, and B cells. The response that is activated is very much dependent on the external surrounding of IL-27. There are many different subsets of T cells, such as Th1, Th2, Th17, Tr1, and Treg cells; IL-27 is greatly involved in ...
BioAssay record AID 146424 submitted by ChEMBL: The receptor binding activity was evaluated as the displacement of specifically bound [3H]-NPY from male Sprague-Dawley rat brain membrane homogenates.
Our research focuses on the chemical synthesis and the biological. investigation of signaling molecules for cells. We are developing. and improving syntheses for three classes of biomolecules:. oligosaccharides, peptides and glycoproteins. Oligosaccharides. are playing a major role in cell-surface binding events, protein. stability and immunology and can be considered an emerging field. in bioscience. Oligosaccharides have potential as diagnostic markers. and vaccines and can be synthesized by chemical and enzymatic. methods. Proteins and glycoproteins are of high interest for biotechnology. since their recombinant production provides many pharmaceutical. products such as cellular growth factors or monoclonal antibodies.. ...
A few years ago, an original concept of cell biology was proposed: whereas the classic dogma postulates that transmembrane receptors are inactive unless bound by their specific ligand, it was suggested that some receptors may be active not only in the presence of their ligand, but also in their absence. In this latter case, the signaling downstream of these unbound receptors leads to apoptosis. These receptors were consequently named
Compare SLAM family member 7 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor...
Эндосиалин (CD248), называемый также TEM1 (от англ. tumor endothelial marker 1), экспрессирован на стромальных клетках растущих тканей на эмбриональной стадии. Во взрослом организме отсутствует, но может быть экспрессирован на опухолевых клетках и при воспалении. Играет роль в росте опухоли и воспалении, но механизм его влияния неизвестен.[1][2]. Экспрессирован на сосудистых эндотелиальных клетках злокачественных опухолей, но не на клетках нормальных сосудов.[3] ...
Leptin Receptor鸡多克隆抗体(ab92615)可与大鼠样本反应并经IHC, ICC/IF实验严格验证。中国75%以上现货,所有产品提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
I Slam (Ya Muslimeen) by Husam Aldiery Lyrics: I slam in slams to slam stereotypical labels out of your mind And Ill slam six hundred and sixty six thousand times for you to enter mine Ill grab your finger and let it grace that button to re-wind Rewind your mind back to the ages of…
Subcellular Localization: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity ...
Receptors are proteins, usually cell surface receptors, which bind to ligands and cause responses in the immune system, including cytokine receptors, growth factor receptors and Fc receptors.
Nokia Slam. Sharing made easy. - Nokia Slam makes it easier than ever to share content such as photos, videos and contacts. Theres no tricky set-up or pairing needed - just select SLAM, connect with another device and thats it. Your content is shared.
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The Exigo Olympic Rack Accessories have been designed specifically for use with the Exigo Olympic Elite racks and double racks.FeaturesSuitable f...
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I dont believe Ive ever seen a dunk rejected in quite this fashion. The old and embittered out there may be reminded of George Tenets slam dunk.
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