We11,12 and others13-15 have shown that βAR stimulation in cardiac myocytes results in apoptosis that is mediated by ROS-dependent activation of JNK and the mitochondrial death pathway.16 This study demonstrates that βAR-stimulated JNK activation and apoptosis in ARVMs require Rac1. We further show for the first time that statins inhibit βAR-stimulated JNK activation and apoptosis and that these effects are due to inhibition of βAR-stimulated Rac1 activation.. A new finding of this study is that βAR stimulation causes Rac1 activation. Furthermore, adenoviral overexpression of the N17Rac1 dominant-negative mutant inhibited βAR-stimulated apoptosis and 3 known steps in the signaling pathway leading to βAR-stimulated apoptosis: JNK activation, cytochrome C release, and caspase-3 activation. Thus, in cardiac myocytes, βAR stimulation couples to Rac1 activation, which is upstream of JNK in the mitochondrial death pathway and necessary for βAR-stimulated apoptosis.. Little is known about the ...
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Genomics has significantly improved our understanding of chronic obstructive pulmonary disease (COPD) over the past decade. Genome-wide association studies have identified a number of genetic variants associated with lung function and susceptibility to COPD,1 2 and have helped explain why only some smokers develop COPD and why never-smokers can also be affected by the disease. Once COPD is diagnosed, reducing the burden of respiratory exacerbations is a clinical priority because these events are associated with accelerated lung function decline3 and increased mortality.4 However, not all patients with COPD experience exacerbations.5 6 Therefore, identifying individuals at increased risk of exacerbations may help target management and improve outcomes. Beyond the susceptibility to COPD, genomics may also help inform the morbidity of COPD. A previously reported twin study suggests that more than 60% of the risk of severe COPD exacerbations can be attributed to genetic factors.7 Among those, ...
... are cell‐surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, including cardiovascular and pulmonary functions
alpha 2a Adrenergic Receptor兔多克隆抗体(ab92650)可与小鼠, 大鼠, 人样本反应并经IHC实验严格验证。所有产品均提供质保服务,中国75%以上现货。
Heart failure remains one of the most highly prevalent and costly syndromes that leads to morbidity and mortality in the United States and increasingly around t...
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alpha 2C Adrenergic Receptor兔多克隆抗体(ab123368)可与人样本反应并经WB实验严格验证。所有产品均提供质保服务,中国75%以上现货。
Goat polyclonal beta 1 Adrenergic Receptor antibody validated for WB, IHC and tested in Human and Rat. Referenced in 4 publications and 2 independent reviews…
Can you pick the Adrenergic Receptor Blockers Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by poorvichhabra
Some biologically plausible mechanisms may explain the p53-AAbs possibly immediate or oblique protecting partMCE Chemical SB-220453 in ovarian most cancers.
Gene-based approach:Empirical P-value = 0.003(EAAO versus HC); Empirical P-value = 0.81(LAAO versus HC); ADRB2 (beta-2adrenoreceptor) gene region that is specifically associated with the early onset form of BD ...
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Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the EPCR gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models.Results: The current meta-analysis suggested that there was a significant association between EPCR gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21-1.66, P=1.30×10-5), recessive (OR: 2.02, 95% CI: 1.44-2.85, P=5.35×10-5), homozygous (OR: 2.24, 95% CI: 1.59-3.16, P=3.66×10-6), and additive genetic models (OR: 1.63, 95% CI: 1.30-2.04, P=2.24×10-5). Conclusions: EPCR gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly
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TY - JOUR. T1 - b1-Adrenoceptors compensate for b3-adrenoceptors in ileum from b3-adrenoceptor knock-out mice. AU - Hutchinson, Dana Sabine. AU - Evans, Bronwyn A. AU - Summers, Roger J. PY - 2001. Y1 - 2001. M3 - Article. VL - 132. SP - 433. EP - 442. JO - British Journal of Pharmacology. JF - British Journal of Pharmacology. SN - 1476-5381. IS - 2. ER - ...
The Paper, Which Describes Pharmacogenetic Enhancement of Effectiveness for Prevention of Atrial Flutter, Was Also Published in the Journal of Cardiac Failure. Westminster, CO, September 9, 2015 - ARCA biopharma, Inc. (Nasdaq: ABIO), a biopharmaceutical company developing genetically-targeted therapies for cardiovascular diseases, today announced that the paper "Bucindolol Prevents Atrial Flutter via the Beta-1 389 Arg/Gly Adrenergic Receptor Polymorphism" will be presented at the 19th annual Scientific Meeting of the Heart Failure Society of America (HFSA) to be held in Washington, D.C. September 26-29, 2015. The paper was recently published in the Journal of Cardiac Failure http://www.onlinejcf.com/article/S1071-9164(15)00366-8/fulltext, the official journal of the Heart Failure Society of America and the Japanese Heart Failure Society. The lead author on the paper is cardiologist-electrophysiologist Ryan G. Aleong of the University of Colorado, Anschutz Medical Campus, and a co-author on the ...
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Data from the Clinical Study BEST Indicate That in the Study Norepinephrine Lowering and Clinical Therapeutic Responses to Bucindolol Were Strongly Influenced b
BioAssay record AID 288801 submitted by ChEMBL: Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cells.
This study assessed the role of adrenergic receptors on the regulation of the uptake of L-dopa and the production of dopamine by… Expand ...
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Looking for online definition of Alpha adrenergic receptor in the Medical Dictionary? Alpha adrenergic receptor explanation free. What is Alpha adrenergic receptor? Meaning of Alpha adrenergic receptor medical term. What does Alpha adrenergic receptor mean?
The aim of the present study was to evaluate the efficacy and β2-adrenoceptor (AR) selectivity of KUR-1246, a new uterine relaxant. Inhibition of spontaneous or drug-induced uterine contractions by KUR-1246 was evaluated in pregnant rats and rabbits by an organ bath method or by a balloon method. The selectivity of KUR-1246 was assessed simultaneously in organs isolated from late-pregnant rats. The affinity of KUR-1246 for human β1-, β2-, and β3-ARs was determined using two radioligands. KUR-1246 suppressed both spontaneous and drug-induced contractions in isolated uteri, the rank order of potency being isoproterenol , KUR-1246 , terbutaline , ritodrine. ICI-118551 (selective β2-AR antagonist) competitively antagonized the KUR-1246-induced inhibition of spontaneous uterine contractions, but CGP-20712A (selective β1-AR antagonist) and SR-58894A (selective β3-AR antagonist) did not. All β-AR agonists tested produced significant inhibition of spontaneous uterine contractions in vivo: ED30 ...
The ß-adrenergic receptors are linked to G proteins. The ß-receptor has three known subtypes. Beta-1 receptors primarily regulate myocardial tissue and affect the rate of contraction via impulse conduction. Beta-2 receptors regulate smooth muscle tone and influence vascular and bronchiolar rela...
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites ...
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites ...
Synonyms for ADRB2 in Free Thesaurus. Antonyms for ADRB2. 175 synonyms for bar: public house, pub, counter, inn, local, lounge, saloon, tavern, canteen, watering hole, boozer, roadhouse, hostelry, alehouse, taproom.... What are synonyms for ADRB2?
Lack of Association of the Trp64Arg Polymorphism of β_3-Adrenergic Receptor Gene with Energy Expenditure in Response to Caffeine Among Young Healthy Women (2008 ...
The β2-AR is a major lipolytic receptor in human fat cells. With the notion that the β2-AR polymorphisms might play a role in obesity, Large et al. (1997)genotyped 140 women with a large variation in body fat mass. The Glu27 homozygotes had an average fat mass excess of 20 kg (Large et al., 1997, Table 1). Neither allele at the Arg16Gly polymorphism was linked to obesity. An investigation of obese men did not give a similar result (Hellstrom et al., 1999). These findings in women will probably stimulate further work and may be applied to the known interethnic variability in obesity.. The codon 164 threonine/isoleucine polymorphism of β2-AR has not received much attention in humans because of the comparative rarity of the less frequent (isoleucine) allele. To investigate the functional significance of this polymorphism in the myocardium, Turki et al. (1996) prepared transgenic mice expressing 45 times the normal endogenous β2-AR. Mice with the mutant 164 Ile and mice with the wild-type ...
Dr. Lee E. Limbird Limbirds research evaluates the structure and function of alpha2-adrenergic receptors and the mechanisms by which they influence multiple physiological functions. Alpha2-adrenergic receptors are molecules on the cell surface that bind the hormones epinephrine or norepinephrine and evoke such physiological functions as the regulation of hormone and neurotransmitter release, platelet aggregation and secretion, vascular contractility, and smooth muscle tone. Limbird and her colleagues are also examining the mechanisms by which alpha2-adrenergic receptors achieve their delivery to specialized domains on the surface of target cells. Limbird earned an undergraduate degree in chemistry from the College of Wooster in Wooster, Ohio, in 1970. She received a Ph.D. in biochemistry from the University of North Carolina, Chapel Hill, in 1973. Before moving to Vanderbilt, Limbird was a member of the departments of medicine and biochemistry at Duke University. From 1979 to 1985 she rose ...
Concentration of β-adrenergic receptor from small antral (SA), preovulatory (PO) and cystic follicular wall. The β-receptor concentration is expressed as fmol
What is ADRA2A? ADRA2A, located on chromosome 10, encodes the α-2A adrenergic receptor, a norepinephrine receptor that is the primary site of action for α-2A agonists. The α-2A adrenergic receptor…. ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
The present study was carried out to determine, first, the cardiac beta -adrenergic receptor characteristics of normal chickens and chickens with heart failure and, second, the characteristics of myocardial beta -adrenergic receptors in non-hypertrophied hearts in broilers exposed to two different altitude and temperature programmes. The density of beta -adrenergic receptors was significantly lower in myocardial cells in right ventricular failure birds compared with healthy birds. The binding capacity of beta -adrenergic receptors was reduced in the non-hypertrophied ventricles after exposure to high altitude in the younger but not in older chickens. At both altitudes, beta -adrenergic receptor binding capacity was not significantly different in low temperature compared with normal temperature birds. These data support the hypothesis of beta -adrenergic receptor downregulation as one of the mechanisms of cardiac cell adaptation to hypertrophy or hypoxia. Second, the acclimatization to high ...
In this paper, we have used the β-adrenoceptor agonist isoproterenol for all the in vivo and in vitro studies. We have extensively shown (Chernogubova et al., 2004, 2005; Hutchinson and Bengtsson, 2006; Dallner et al., 2006) that the β3-adrenoceptor is the only β-adrenoceptor subtype that increases glucose uptake via increased de novo synthesis of GLUT1 in brown adipocytes from wild-type mice in vitro through the use of specific agonists and antagonists (Chernogubova et al., 2004, 2005; Dallner et al., 2006). The exception occurs in β3-adrenoceptor knockout mice, where there is compensation by both the α1- and β1-adrenoceptors that is not evident in cultures derived from wild-type mice (Chernogubova et al., 2005). Hence we strongly believe that the effects of isoproterenol in vitro are due solely to activation of β3-adrenoceptors. With respect to glucose uptake in vivo, isoproterenol is still effective in promoting glucose uptake into BAT in β1β2-adrenoceptor knockout mice (Fig. 4 A), ...
Adverse drug reactions associated with the use of beta blockers include: nausea, diarrhea, bronchospasm, dyspnea, cold extremities, exacerbation of Raynauds syndrome, bradycardia, hypotension, heart failure, heart block, fatigue, dizziness, alopecia (hair loss), abnormal vision, hallucinations, insomnia, nightmares, sexual dysfunction, erectile dysfunction and/or alteration of glucose and lipid metabolism. Mixed α1/β-antagonist therapy is also commonly associated with orthostatic hypotension. Carvedilol therapy is commonly associated with edema.[44] Due to the high penetration across the blood-brain barrier, lipophilic beta blockers, such as propranolol and metoprolol, are more likely than other less lipophilic beta blockers to cause sleep disturbances, such as insomnia, vivid dreams and nightmares.[45] Adverse effects associated with β2-adrenergic receptor antagonist activity (bronchospasm, peripheral vasoconstriction, alteration of glucose and lipid metabolism) are less common with ...
beta-1 Adrenergic Receptors: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
TY - JOUR. T1 - β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling. AU - Teoh, Jian Peng. AU - Bayoumi, Ahmed S.. AU - Aonuma, Tatsuya. AU - Xu, Yanyan. AU - Johnson, John A.. AU - Su, Huabo. AU - Weintraub, Neal L.. AU - Tang, Yaoliang. AU - Kim, Il Man. PY - 2018/5. Y1 - 2018/5. N2 - Rationale: MicroRNAs (miRs) are small, non-coding RNAs that function to post-transcriptionally regulate target genes. First transcribed as primary miR transcripts (pri-miRs), they are enzymatically processed by Drosha into premature miRs (pre-miRs) and further cleaved by Dicer into mature miRs. Initially discovered to desensitize β-adrenergic receptor (βAR) signaling, β-arrestins are now well-appreciated to modulate multiple pathways independent of G protein signaling, a concept known as biased signaling. Using the β-arrestin-biased βAR ligand carvedilol, we previously showed that β-arrestin1 (not β-arrestin2)-biased β1AR ...
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Background: β1-adrenergic receptor blockers are an important drugs recommended as first-line treatment of Heart Failure (HF) as they improve survival in left ventric..
The mechanisms of desensitization and resensitization of the dopamine D1 receptor are not well understood. Although the high homology of the D1 receptor with the β2-adrenergic receptor might indicate that similar mechanisms regulate the responsiveness of the receptors, even subtypes of β-adrenergic receptors differ substantially in this respect (Shiina et al., 2000). For β-adrenergic receptors, a distinction has been made between desensitization that is homologous (resulting from stimulation of the same receptor) or heterologous (resulting from stimulation of a different receptor subtype, or nonreceptor-mediated activation of a second messenger) (Harden, 1983). A mechanism for heterologous desensitization is phosphorylation of the receptor by PKA (Clark et al., 1989; Hausdorff et al., 1989), whereas homologous desensitization of the β2-adrenergic receptor involves phosphorylation of the agonist-occupied receptor by both GRK (Benovic et al., 1986) and PKA (Post et al., 1996; Moffett et al., ...
BioAssay record AID 36627 submitted by ChEMBL: Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells.
Wei, W.,Ming, X.,Yi, Z. Y.,et al. Autoimmunity Mediated Down-regulation Of B 2-adrenergic Receptor In COPD[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2010,181 ...
ADRB3, the β3-adrenergic receptor, has been connected to obesity and metabolic conditions. The Trp64Arg variant is a susceptibility gene polymorphism for T2D. [PMID 24972470] ...
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A gene-drug interaction has been indicated between beta-1 selective beta-blockers and the Arg389Gly polymorphism (rs1801253) in the adrenergic beta-1 receptor gene (ADRB1). We studied the effect of the ADRB1 Arg389Gly polymorphism on plasma renin activity (PRA) and heart rate (HR) and the genotype-dependent response to metoprolol and exercise. Twenty-nine healthy male subjects participated in 2 treatment periods (placebo and metoprolol). A 15-min submaximal exercise test was performed after each treatment period, and PRA and HR were measured before and after exercise. Before exercise, median PRA was lower in Gly/Gly subjects than in Arg/Arg subjects after both placebo (P = 0.030) and metoprolol treatment (P = 0.020). After placebo, the exercise-induced PRA increase was greater in Gly/Gly than in Arg/Gly and Arg/Arg subjects (P = 0.033). The linear association between log(PRA) and log(metoprolol concentration) varied significantly between genotypes (P = 0.024). In Gly/Gly subjects, PRA decreased ...
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. ...
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