Synonyms for alpha-adrenergic receptor in Free Thesaurus. Antonyms for alpha-adrenergic receptor. 2 synonyms for alpha-adrenergic receptor: alpha receptor, alpha-adrenoceptor. What are synonyms for alpha-adrenergic receptor?
Cerebral and renal alpha-adrenergic receptors play an important role in the control of blood pressure. We studied alpha-adrenergic receptors in the cerebral and renal cortex of Milan hypertensive strain (MHS) and normotensive strain (MNS) rats, a genetic model of spontaneous hypertension linked to a kidney abnormality. Binding of the selective alpha 1-adrenergic antagonist [3H]prazosin and the alpha 2-adrenergic antagonist [3H]rauwolscine was used for receptor studies in tissues of prehypertensive (24-day-old) and hypertensive (60-day-old) rats. In the cerebral cortex, no between-strain differences in alpha 1-adrenergic and alpha 2-adrenergic receptor density and affinity were observed in prehypertensive and hypertensive periods. The density of these receptors increased similarly with age in MHS and MNS rats. In the renal cortex, the differences between MHS and MNS rats concerned alpha 2-adrenergic receptors only. Compared with their age-matched normotensive controls, MHS rats showed 1) a lower ...
TY - JOUR. T1 - Epinephrine decreases glucose clearance in man. T2 - An α adrenergic effect independent of inhibition of insulin secretion. AU - Rizza, R.. AU - Miles, J.. AU - Verdonk, C.. PY - 1979/1/1. Y1 - 1979/1/1. UR - http://www.scopus.com/inward/record.url?scp=0018389251&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018389251&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018389251. VL - 27. SP - 375A. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 2. ER - ...
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An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet ...
Looking for online definition of Alpha adrenergic receptor in the Medical Dictionary? Alpha adrenergic receptor explanation free. What is Alpha adrenergic receptor? Meaning of Alpha adrenergic receptor medical term. What does Alpha adrenergic receptor mean?
The existence and significance of a hormone-sensitive, rapidly mobilizable intracellular pool of Ca2+ in hamster brown-fat cells was investigated with 45Ca2+-labelling techniques. It was shown that such a pool existed and was probably located within the abundant mitochondria. It was rapidly mobilized by norepinephrine (median effective concentration 50 nM) through alpha-adrenergic mechanisms. The mobilization of Ca2+ from the intracellular stores (mitochondria) required the presence of extracellular Na+, but not of Ca2+, K+ or Mg2+. It is concluded that the experiments are in agreement with a hypothesis linking the mobilization of intracellular Ca2+ pools with an alpha-adrenergically-induced increase in plasma membrane Na+ permeability (observed as a membrane depolarization), and a subsequent activation of the mitochondrial Na+/Ca2+ exchange, leading to mobilization of mitochondrial Ca2+ and the mediation of alpha-adrenergic effects as a result of an elevated cytosolic Ca2+ level.. ...
To more fully characterize the alterations in myocardial adrenergic and cholinergic receptors induced by the diabetic state, we investigated the binding characteristics of (-) [3H] dihydroalprenolol to beta adrenergic receptors (bAR), [3H] prazosin to alpha adrenergic receptors (aAR), and [3H] quinuclidinyl-benzilate to muscarinic cholinergic receptors (MCR) in myocardial membranes derived from rats 8 wk after treatment with streptozotocin. We also studied an equal number of animals from three control groups: free-eating nondi-abetics, pair-weighted nondiabetics, and streptozoto-cin-treated animals treated daily with insulin.. Diabetic hearts demonstrated 27% fewer bAR (P , 0.01) and 31% fewer aAR (P , 0.01) than free-eating controls, without changes in MCR, and without changes in antagonist affinity, agonist affinity, or agonist slope factor (pseudo-Hill coefficient) for any class of receptors. Food restriction had no effect on receptor characteristics, and treatment of diabetic rats with ...
3H]Dihydroergocryptine, a nonselective alpha adrenergic antagonist, the alpha-1 selective antagonist, [3H]prazosin and the alpha-2 selective antagonist, [3H]yohimbine, were used to study binding sites in rat renal membranes. To establish a correlation between binding and a biological function, the ability of alpha adrenergic agents to stimulate or inhibit vasoconstriction was quantified in vitro using an isolated perfused kidney preparation. Binding with each radioligand was rapid, saturable and specific. Moreover, the order of potencies of a variety of adrenergic agents, determined by competitive inhibition studies, suggested that the binding of each radioligand was to sites with alpha adrenergic specificity. The total number of binding sites in these rat renal membranes. determined with [3H]dihydroergocryptine (Bmax, 212 fmol/mg of protein; KD, 12.8 nM) was approximately equal to the sum of binding site concentrations determined with the alpha-1 and alpha-2 selective radioligands (Bmax, 57 and ...
TY - JOUR. T1 - Presynaptic modulation of the norepinephrine-induced β-adrenergic receptor desensitization phenomenon in vivo. AU - Nakamura, I.. AU - Yoshikawa, T.. AU - Anzai, T.. AU - Baba, A.. AU - Iwata, M.. AU - Wainai, Y.. AU - Suzuki, M.. AU - Ogawa, S.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Background: In vivo administration of norepinephrine fails to cause β-adrenergic receptor desensitization. However, short-term exposure of cultured cells to norepinephrine induces the phenomenon in vitro. We sought to identify the local regulatory mechanisms responsible for in vivo β-adrenergic receptor desensitization in congestive heart failure. Methods and Results: Control rabbits received norepinephrine (n = 7) or saline (n = 7) for 1 week, and rabbits with chemical denervation induced by 6-hydroxydopamine also received norepinephrine (n = 7) or saline (n = 7). Myocardial norepinephrine content decreased 80% in both groups of denervated rabbits. β1-Adrenergic receptor density in denervated ...
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The invention features polymeric hydrogel contact lenses containing an anti-glaucoma medication, such as a beta adrenergic receptor antagonist, e.g., timolol maleate, or an alpha adrenergic receptor agonist, e.g., brimonidine tartrate, and methods of fabrication and uses thereof. A medication is passively transferred into a contact lens by absorption from a dilute aqueous solution. Such treated lenses are contacted with the ocular fluid of an individual to treat glaucoma.
Obesity often leads to hypertension. Previous work from my lab demonstrated that the adipocyte-derived hormone leptin reduces the ability of the aorta to contract in response to adrenergic stimulation, likely due to a decreased expression of the aorta alpha-adrenergic receptors. However, it is not known whether leptin decreases the expression of alpha-adrenergic receptors in such arteries like the mesenteric and renal arteries that play a key role in the control of blood pressure. To determine whether leptin decreases alpha-adrenergic receptor expression in renal and mesenteric arteries, I infused leptin (10ug/day) by implanting subcutaneous mini-pumps in five male C57bl/6 mice. Five mice did not receive leptin and served as controls. After seven days of treatment I euthanized nine mice as one mouse died. Renal and mesenteric arteries were taken from the mice and mRNa was extracted from the arteries. Reverse Transcription (RT) was completed in order to induce the transcription of mRNA into cDNA. ...
Although it is now well documented (6, 8) that pial as well as intracerebral vessels are amply supplied with sympathetic adrenergic nerves which, as shown for pial arteries, fulfill ultra-structural...
Semantic Scholar extracted view of Influence of adrenergic receptor stimulation on glucose metabolism during starvation in man: effects on circulating levels of insulin growth hormone and free fatty acids. by Robert I Misbin et al.
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Ergot alkaloid and alpha adrenergic receptor antagonist with vasoconstrictor effect. Indicated in the treatment of acute migraine attack, usually together with caffeine. Oral administration every half hour if necessary, up to a maximum of 6 mg per day (Sandoz 2012, AEMPS 2009). Since the last update we have not found published data on its excretion in breastmilk. Its pharmacokinetic data (high molecular weight and high plasma protein binding) makes it unlikely it will transfer into breastmilk in significant amounts. Although gastrointestinal absorption is 62%, hepatic metabolism makes bioavailability less than 5% (AEMPS 2009), which impedes its transfer from breastmilk to infant plasma, except in premature infants and the immediate neonatal period when there may be greater intestinal permeability. Other ergot alkaloids, such as bromocriptine, inhibit prolactin secretion, but administration of 3mg daily of ergotamine during the first week postpartum did not affect the production of
Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its α-adrenergic receptor-stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the β-adrenergic effects of epinephrine are controversial because they may increase myocardial work and reduce subendocardial perfusion.3 Although epinephrine has been used universally in resuscitation, there is a paucity of evidence to show that it improves outcome in humans. For a number of years researchers and clinicians have also questioned the optimal dose of epinephrine. The "standard" dose of epinephrine (1.0 mg) is not based on body weight. Historically a standard dose of 1 mg epinephrine was used in surgical operating rooms for intracardiac injections.4 5 6 Surgeons observed that 1 to 3 mg of intracardiac epinephrine was effective in restarting the arrested heart.6 7 When these and other experts first ...
Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient...
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Prazosin, 1-(4-amino-6,7-dimetoksi-2-hinazolinil)-4-(2-furoil)-piperazin, se sintetiše iz 2-amino-4,5-dimetoksibenzoinske kiseline, koji nakon reakcije sa natrijum cijanatom podleže heterociklizaciji do 2,4-dihidroksi-6,7-dimetoksihinazolina. Supstituisanje hidroksilnih grupa ovog jedinjenja atomima hlora reakcijom sa tionil hloridom, ili smešom fosfor oksihlorida sa fosfor pentahloridom daje 2,4-dihloro-6,7-dimetoksihinazolin. Naknadnom reakcijom sa amonijakom, atom hlora u C4 poziciji pirimidinskog prstena se zamenjuje amino grupom, što dovodi do formiranja 4-amino-2-hloro-6,7-dimetoksihinazolina. Njegovim uvođenjem u reakciju sa 1-(2-furoil)piperazinom formira se prazosin.[3][4][5][6][7][8][9][10][11][12]. ...
This study assessed the role of adrenergic receptors on the regulation of the uptake of L-dopa and the production of dopamine by… Expand ...
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Drop tests. Theres much to be said about how eye drops and other examination maneuvers can be used as aids in your differential diagnosis. Take a case of Horners Syndrome, for example. Most people just image the entire sympathetic pathway anyway, but its kind of interesting to know. So, by giving a patient 0.5% topical apraclonidine to both eyes, the affected eye by the Horners Syndrome will dilate to a much greater size than the contralateral pupil. This is due to subacute (,48hours) or chronic denervation of that eye leading to overexpression of alpha adrenergic receptors and hypersensitivity of that pupil to sympathetic stimulation. This confirms the Horners, but wont tell you where the lesion is. Next, you administer hydroxyamphetamine, which stimulates release of norepinephrine from the intact post-ganglionic neuron (3rd order neuron in the 3-neuron Horner pathway). If the affected pupil also dilates in response to these eye drops, then the 3rd order neuron is alive and thus the ...
BACKGROUND AND PURPOSE: In mouse tail arteries, selective alpha(2)-adrenoceptor antagonism with rauwolscine caused powerful dilation during constriction to the alpha(1)-adrenoceptor agonist phenylephrine. This study therefore assessed phenylephrines selectivity at vascular alpha-adrenoceptors and the mechanism(s) underlying dilation to rauwolscine. EXPERIMENTAL APPROACH: Mouse isolated tail arter
Dan E. Berkowitz, David T. Price, Elizabeth A. Bello, Stella O. Page, Debra A. Schwinn; Localization of Messenger RNA for Three Distinct α2-Adrenergic Receptor Subtypes in Human Tissues: Evidence for Species Heterogeneity and Implications for Human Pharmacology. Anesthesiology 1994;81(5):1235-1244. Download citation file:. ...
Cocaine increases production of the potent vasoconstrictor endothelin, and simultaneously decreases production of nitrous oxide, a powerful vasodilator. As a result of alpha-adrenergic stimulation, co... more
... are cell‐surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, including cardiovascular and pulmonary functions
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Ruuskanen JO, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan YL, Postlethwait JH, Johnson MS, Larhammar D, Scheinin M (2004). „Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish". Molecular Biology and Evolution. 21 (1): 14-28. PMID 12949138. doi:10.1093/molbev/msg224 ...
Minipress is classified as an alpha-adrenergic blocker. The active ingredient of the medication, Prazosin, stimulates an inevitable action relaxing the arteries and veins. This way, the treatment produces easier blood circulation in the body.
No, he draws a pixel with r=1,g=0,b=0,a=0. With a blend mode of ADD/ALPHA/INVERSE this would mean that r/g/b/a is multiplied with a first so everything is multiplied with 0 so it all gets 0. Nothing at all is drawn. With the blend mode he uses (ADD/ONE/ZERO) the r/g/b/a are simply copied (the destination is multiplied with 0, the source is multiplied with 1 therefore left as is). The alpha value (a=0) is not used at all.. The only unexpected thing is that when he reads the pixel back the alpha magically turned 1. This is a bug if the bitmap does have an alpha channel, otherwise is expected (a bitmap without alpha always behaves like a bitmap with an alpha channel of all 1). ...
No, he draws a pixel with r=1,g=0,b=0,a=0. With a blend mode of ADD/ALPHA/INVERSE this would mean that r/g/b/a is multiplied with a first so everything is multiplied with 0 so it all gets 0. Nothing at all is drawn. With the blend mode he uses (ADD/ONE/ZERO) the r/g/b/a are simply copied (the destination is multiplied with 0, the source is multiplied with 1 therefore left as is). The alpha value (a=0) is not used at all.. The only unexpected thing is that when he reads the pixel back the alpha magically turned 1. This is a bug if the bitmap does have an alpha channel, otherwise is expected (a bitmap without alpha always behaves like a bitmap with an alpha channel of all 1). ...
Yohimbine Hydrochloride Alias: Corynine;Aphrodine CAS No: 65-19-0 Einecs No: 200-600-4 MF: C21H27ClN2O3 MW: 390.91 Purity: 98% Appearance:White crystalline
aldrin-transdiol: dieldrin metabolite suggested as active neurotoxic form; RN refers to (1 alpha,2 alpha,3 beta,4 alpha,4a beta,5 alpha,8 alpha,8a beta)-isomer