The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor type 1, which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol, the active agent in cannabis, and other phytocannabinoids (plant cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG). CB2 was cloned in 1993 by a research group from Cambridge looking for a second cannabinoid receptor that could explain the pharmacological properties of tetrahydrocannabinol. The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1) receptor, discovered in 1990. The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system. ...
The endocannabinoid system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate. A functional interaction between endocannabinoids and the serotonergic system has already been suggested. Previously, we showed that cannabinoid type 1 (CB1) receptor mRNA and protein are localized in serotonergic neurons of the raphe nuclei, implying that the endocannabinoid system can modulate serotonergic functions. In order to substantiate the physiological role of the CB1 receptor in serotonergic neurons of the raphe nuclei, we generated serotonergic (5-HT) neuron-specific CB1 receptor-deficient mice, using the Cre/loxP system with a tamoxifen-inducible Cre recombinase under the control of the regulatory sequences of the tryptophan hydroxylase 2 gene (TPH2-CreERT2), thus, restricting the recombination to 5-HT neurons of the central nervous system. Applying several different behavioral paradigms, we revealed that mice lacking the
Title:Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor. VOLUME: 14 ISSUE: 5. Author(s):Shuang Han, Jiong-Jiong Chen and Jian-Zhong Chen. Affiliation:College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, P. R. China.. Keywords:Cannabinoid receptors, CB2, GPCRs, selective ligand, structure-activity relationship.. Abstract:Cannabinoid receptors, belonging to the superfamily of G-protein coupled receptors, play a major role in pathophysiology of a wide range of disparate diseases. Cannabinoid CB2 receptor, which mainly locates in peripheral tissues, represents as a promising drug target for the treatment of pain, osteoporosis, liver disorders, and so on without serious CNS side effects. In the past decades, the identification and optimization of selective ligands for the CB2 receptor has been a major objective in drug discovery. In the present review, we describe recent advances in the development of ...
TY - PAT. T1 - 1,5-diaryl-pyrazoles as cannabinoid receptor neutral antagonists useful as therapeutic agents. AU - Greig, Iain Robert. AU - Ross, Ruth Alexandra. AU - Pertwee, Roger Guy. PY - 2008/8/21. Y1 - 2008/8/21. N2 - The present invention pertains to cannabinoid (CB) receptor neutral antagonists, and especially CB1 neutral antagonists, and including, for example, certain 1,5-di-aryl-pyrazole compounds. The present invention also pertains to the use of such compounds in the treatment of diseases and disorders that are ameliorated by treatment with a neutral antagonist of the cannabinoid type 1 (CB1) receptor, for example: an eating disorder; obesity; a disease or disorder characterised by an addiction component; addiction; withdrawal; smoking addiction; smoking withdrawal; drug addiction; drug withdrawal; smoking cessation therapy; a bone disease or disorder; osteoporosis, Pagets disease of bone; bone related cancer; a disease or disorder with an inflammatory or autoimmune component; ...
This article is part of a themed section on Emerging Areas of Opioid Pharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.14/issuetoc.
TY - JOUR. T1 - Brain Cannabinoid CB2 Receptor in Schizophrenia. AU - Ishiguro, Hiroki. AU - Horiuchi, Yasue. AU - Ishikawa, Maya. AU - Koga, Minori. AU - Imai, Keiko. AU - Suzuki, Yoshimi. AU - Morikawa, Miyuki. AU - Inada, Toshiya. AU - Watanabe, Yuichiro. AU - Takahashi, Makoto. AU - Someya, Toshiyuki. AU - Ujike, Hiroshi. AU - Iwata, Nakao. AU - Ozaki, Norio. AU - Onaivi, Emmanuel S.. AU - Kunugi, Hiroshi. AU - Sasaki, Tsukasa. AU - Itokawa, Masanari. AU - Arai, Makoto. AU - Niizato, Kazuhiro. AU - Iritani, Shyuji. AU - Naka, Izumi. AU - Ohashi, Jun. AU - Kakita, Akiyoshi. AU - Takahashi, Hitoshi. AU - Nawa, Hiroyuki. AU - Arinami, Tadao. PY - 2010/5/15. Y1 - 2010/5/15. N2 - Background: Neural endocannabinoid function appears to be involved in schizophrenia. Two endocannabinoid receptors, CB1 and CB2, are found in the brain and elsewhere in the body. We investigated roles of CB2 in schizophrenia. Materials and Methods: An association study was performed between tag single nucleotide ...
Mediterranean Yearbook (Med) is a full-text scholarly ejournal. The bulk of the articles here are not relevant to the arts and humanities, but there are occasional themed sections on cultural and media issues. Of particular note is the themed section The Role of the Media in the Mediterranean (four articles in the 2003/2004 issue). Other articles of interest include: Summer Festivals in Morocco: International Influence and a Factor of Social Cohesion; The Influence of Arab Information C ...
Cannabinoid agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to assess these preclinical effects of cannabinoids is intracranial self-stimulation (ICSS), where an animal performs a response to receive electrical stimulation of a specific brain area or circuit known to be involved in reward. Drugs of abuse, such as psychomotor stimulants, facilitate responding for ICSS. While a few studies have shown facilitating effects of cannabinoids in rats, several have shown the opposite effect, and no studies so far have evaluated cannabinoids in mouse ICSS. Furthermore there are no studies evaluating specific inhibitors of endocannabinoid catabolic enzymes in ICSS in any species. In these studies we assessed the cannabinoid agonist THC, as well
With Sativex approved in a number of countries and expected to find approval in many more in the coming months, the concept of cannabinoid medicine has been proved as more than a kooky herbal remedy. "The Sativex approval has validated the platform; it says you can make a medicine out of these materials and in this way. So big pharma have said, Fine, thats great; now we understand. I think that you will find a lot more interest in the cannabinoid system now that Sativex has been approved.". So what is the current state of cannabinoid research? As the head of one of the worlds leading cannabinoid research groups, Guy is well-positioned to comment. One of his fundamental tasks is to debunk the myths and preconceptions about this emerging area of science. "We have to take more care to provide far more fundamental data than if wed just invented a molecule and said, Look, this is what it does, please accept it. So there is an education process. And its very cultural, very different throughout ...
Background: In prostate cancer, tumour expression of cannabinoid CB1 receptors is associated with a poor prognosis. One explanation for this association comes from experiments with transfected astrocytoma cells, where a high CB receptor expression recruits the Akt signalling survival pathway. In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well-characterised prostate cancer tissue microarray.. Methodology/Principal Findings: Phosphorylated Akt immunoreactivity (pAkt-IR) scores were available in the database. CB1 receptor immunoreactivity (CB1IR) was rescored from previously published data using the same scale as pAkt-IR. There was a highly significant correlation between CB1IR and pAkt-IR. Further, cases with high expression levels of both biomarkers were much more likely to have a more severe form of the disease at diagnosis than those with low expression levels. The two biomarkers had additive effects, rather than an ...
Cannabinoids bind the cannabinoid receptors CB1 and CB2, expressed both in the central nervous system as well as in the periphery. The affinity to the receptors varies between the cannabinoid and while some may bind CB1 or CB2, others have the affinity to bind both. Furthermore, some of the cannabinoids act as agonists to the receptor while others exert antagonistic effects. The endogenous ligands of the receptors (endocannabinoids) are lipophilic signaling molecules, similar to the phytocannabinoids.. CB receptors are G-coupled receptors leading to decreased levels of cyclic AMP and thus to an inhibitory effect. They have been shown to possess a role in various physiological and pathological processes. Thus, the endocannabinoid system participate in neurotransmission, neurogenesis, modulation of insulin metabolism, proliferation and immune system modulation. However, it has been shown that cannabinoids exert some of their effects via a non CB receptor dependent mechanism.. ...
Title:Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing to Drug Addiction: Effect of Ovarian Hormones. VOLUME: 20 ISSUE: 13. Author(s):Maria Paola Castelli, Paola Fadda, Angelo Casu, Maria Sabrina Spano, Alberto Casti, Walter Fratta and Liana Fattore. Affiliation:CNR National Research Council of Italy, Neuroscience Institute - Cagliari, @ Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato (Cagliari), Italy.. Keywords:Sex difference, ovariectomy, oestrogen, CB1 receptor and [35S]GTPγS binding, locomotor activity, social interaction, anxiety, prepulse inhibition.. Abstract:Sex-dependent differences are frequently observed in the biological and behavioural effects of substances of abuse, including cannabis. We recently demonstrated a modulating effect of sex and oestrous cycle on cannabinoid-taking and seeking ...
Contributions from chemistry to the area of life sciences are enormous. Chemicals in natural or synthetic forms have been used in health and clinical areas as long as history can be traced, and advancements in humanitys understanding of the chemical nature of making and breaking bonds have contributed to unprecedented developments in clinical chemistry. A section in this issue of The Chemist is dedicated to the theme Clinical Chemistry edited by Dr. Margot Hall. Dr. Hall was kind enough to solicit manuscripts for this themed section, as well as doing all the hard work associated with the process of editing it. For a summary of the manuscripts in this section, I encourage you to read the guest editorial by Dr. Hall in this issue of the journal. In addition to the themed section on Clinical Chemistry, there are contributions from others. Bethany Davis describes a thought provoking way to encourage the participation of girls in chemistry through exploring the chemistry of makeup. She was invited ...
A section in this issue of The Chemist is dedicated to the theme Clinical Chemistry edited by Dr. Margot Hall. Dr. Hall was kind enough to solicit manuscripts for this themed section, as well as doing all the hard work associated with the process of editing it. For a summary of the manuscripts in this section, I encourage you to read the guest editorial by Dr. Hall in this issue of the journal. In addition to the themed section on Clinical Chemistry, there are contributions from others. Bethany Davis describes a thought provoking way to encourage the participation of girls in chemistry through exploring the chemistry of makeup. She was invited to write this piece in The Chemist based upon her well-known outreach efforts to promote chemistry among girls in schools and colleges. Encouraging the participation of women in general in the sciences is a national priority. On the other topics, Leah Eller presents a review of the book Organic Structure Analysis (second edition), and Kenneth Abate ...
Liver fibrosis, a major contributor to liver-related mortality with lack of effective treatment. It is associated with increased activity of the CB1R system, and the CB1R antagonist rimonabant mitigates fibrosis in animal models. However, the antifibrotic efficacy is low, and neuropsychiatric side effects halted its therapeutic development. Liver fibrosis is also associated with increased activity of iNOS, and iNOS inhibitors have been shown to mitigate liver fibrosis. In order to improve the safety and antifibrotic efficacy of CB1R antagonism, we have developed highly potent, orally bioavailable hybrid CB1R antagonists that are behaviorally inactive due to low brain penetrance, and have additional activity as iNOS inhibitors. We have tested the antifibrotic efficacy of the compound in a liver fibrosis induced by bile-duct ligation (BDL). (-)-MRI1867 (CB1R antagonist/iNOS inhibitor) selectively block peripheral CB1R (Ki 2.5 nM) due to its low brain penetrance. (-)-MRI1867 directly inhibits iNOS ...
The aim of this study was to determine if the neutral cannabinoid CB₁ receptor antagonist, AM4113, regulates body weight in the rat via changes in food intake. We confirmed that the AM4113-induced reduction in food intake is mediated by CB₁ recep
Cannabinoid-1 receptors (CB1R) exist primarily on central and peripheral neurons, where activation of these receptors is associated with regulation of neurotransmitter release.. Cannabinoid-2 receptors (CB2R) are found mainly on immune cells and in selected areas of the nervous system. Drugs targeting these receptors have been demonstrated to have anti-inflammatory actions.. Cannabinoid receptors, endocannabinoids and biosynthetic and degradative enzymes for these endogenous ligands form the endocannabinoid sytem. This important biological system is upregulated during sepsis, suggesting that drugs that modulate the endocannabinoid system may represent a therapeutic target in the treatment of local and systemic inflammation associated with sepsis.. However, to date, experimental studies involving CB1R and CB2R ligands in models of sepsis have been contradictory and it is unclear whether cannabinoids mediate pro- or anti- inflammatory actions, or what the contribution of individual cannabinoid ...
In 2017, Export of Sinkers, Needles and Other Articles Used in Forming Stitches from Finland was 5072 US Dollars. Discover more data with NationMaster!
ABSTRACT: Previous studies have shown that modulation of the receptor-mediated cannabinoid system during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects. However in this context, little is known about how selective activation of the cannabinoid type-2 receptor (CB2R) affects the activated state of the brain endothelium and blood brain ... Continue Reading ...
Cannabinoid/Terpene Profile. Cannabinoid profiling during the growing stage enables the identification of plants that might have unique cannabinoid profiles of interest. These plants can provide growers with differentiated products and a competitive advantage in the market. Performing an analysis of compounds like cannabidiolic acid (CBDA) while a plant is still growing provides useful information for the optimization of growing conditions. Terpene profiling is also important as terpenes are primarily responsible for the taste and smell of cannabis. A terpene profile will provide further data in developing differentiated strains or products with optimum organoleptic qualities.. ...
SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse biochemical, physiological and behavioral effe
Cannabinoids have long been known to have potent psychotropic actions, but their wide-ranging effects on the cardiovascular system are just beginning to be unraveled.. In anesthetized rat models, intravenously administered anandamide produces a triphasic hemodynamic response (28): a brief period of vagally mediated bradycardia and hypotension, followed by a transitory pressor reaction, and a relatively prolonged vasodepressor response. The latter is the dominant effect of anandamide in animal models, and it results from CB1-mediated inhibition of norepinephrine release from presynaptic nerve terminals (29). In humans, acute administration of the cannabinoids produces vasodilation and tachycardia with a variable net effect on systemic blood pressure (30), but long-term use of THC results in CB1-mediated hypotension and bradycardia (31,32).. Although CB1receptors are mostly expressed on the neuronal terminals, there is evidence showing that other cell types express these receptors and participate ...
The cannabinoid 1 receptor (CB1R) is one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system. CB1R involvement in multiple physiological processes, especially neurotransmitter release and synaptic function, has made this GPCR a prime drug discovery target, and pharmacological CB1R activation has been demonstrated to be a tenable therapeutic modality. Accordingly, the design and profiling of novel, drug-like CB1R modulators to inform the receptors ligand-interaction landscape and molecular pharmacology constitute a prime contemporary research focus. For this purpose, we report utilization of AM3677, a designer endocannabinoid (anandamide) analogue derivatized with a reactive electrophilic isothiocyanate functionality, as a covalent, CB1R-selective chemical probe. The data demonstrate that reaction of AM3677 with a cysteine residue in transmembrane helix 6 of human CB1R (hCB1R), C6.47(355), is a key feature of AM3677s ligand-binding motif. Pharmacologically, ...
The limited effectiveness of current therapies against Alzheimers disease (AD) highlights the need for intensifying research efforts devoted to developing new agents for preventing or retarding the disease process. During the last few years, targeting the endogenous cannabinoid system has emerged as a potential therapeutic approach to treat Alzheimer. The endocannabinoid system is composed by a number of cannabinoid receptors, including the well-characterized CB1 and CB2 receptors, with their endogenous ligands and the enzymes related to the synthesis and degradation of these endocannabinoid compounds. ...
Definition : Immunoassay reagents intended to perform qualitative analyses on a body fluid sample (typically urine) to detect cannabinoid levels and/or cannabinoid metabolite levels in a short period of time, typically several minutes.. Entry Terms : "Metabolite Determination Reagents, Cannabinoid, Rapid Test" , "Marijuana Rapid Test Determination Reagents" , "Marijuana Determination Reagents" , "Hashish Rapid Test Determination Reagents" , "Hashish Determination Reagents" , "Cannabinoid Determination Reagents" , "Cannabinoid Metabolite Reagents, Rapid Test" , "Cannabinoid Determination Reagents, Rapid Test" , "Reagents, Immunoassay, Rapid Test, Drug-of-Abuse, Cannabinoid/Metabolite". UMDC code : 20118 ...
Not too long ago, a drug called rimonabant seemed to be just such a magic bullet. Rimonabant blocked the receptors in the body that are sensitive to cannabinoids like THC. There are two known varieties of cannabinoid receptors, by the way, CB1 and CB2, though they stand among other multi-purpose receptors that are sensitive to…
α-Pinene is a monoterpene found in conifers and believed to enhance memory (Perry et al., 2000). α-Pinene did alter neurotransmission, but like limonene, it did reduced CB1 signaling (F(6,84)=3.198, P=0.0071).. Discussion. Terpenoids are cannabinoid-associated terpenes that are continuing to find their way into consumer interests due to their often-claimed therapeutic benefits, though there is little understanding of their actual effects on cannabinoid signaling. We tested several of the more widely promoted terpenes: myrcene, linalool, limonene, α-pinene, and nerolidol in a well-characterized neuronal model that utilizes endogenous cannabinoid signaling. Our chief findings are that most terpenoids either had no effect, or a modest inhibitory effect on cannabinoid signaling at 1μM. The exception was nerolidol, which had dual, opposing effects. Nerolidol reduced cannabinoid signaling, likely by inhibiting endocannabinoid synthesis, but also enhanced maximal CB1 signaling. This suggests that ...
A pentacyclic hybrid cannabinoid (4) has been synthesized, which combines structural elements of traditional cannabinoids and cannabmimetic indoles. Cannabinoid 4 contains a 1-pentylindole structure fused to the 2,3-positions of the partially reduced hydroxydibenzopyran system of THC. The successful approach to 4 employed 9-benzoyl-5,7-dimethoxy-1,2,3,4-tetrahydrocarbazole (17) as the starting material.
To get a free copy of An Easy Guide to Breastfeeding for African American Women, visit http://www.womenshealth.gov/pub/BF.AA.pdf.. National Breastfeeding Hotline 1-800-994-9662 (Available 9 a.m. - 6 p.m. M-F, EST). African American Breastfeeding Alliance 1-877-532-8535. International Board Certified Lactation Consultant-To find an IBCLC near you, visit http://www.ilca.org. La Leche League International 1-800-LA LECHE or 1-847-519-7730 or visit http://www.lalecheleague.org. La Leche League International has trained mothers who have breastfed their own babies known as La Leche League Leaders. These women are available to answer any and all questions about breastfeeding. The local La Leche League contact information for Memphis, TN is: LLL of Memphis East Melanie 901-324-8215. LLL of Germantown Emily 901-685-8832. Phone Help from LLL: Anne 901-251-9036 - phone help only LLL of Memphis East meets on the first Thursday of each month at 10:30 a.m. at the St. Johns Episcopal Church - Family Life ...
We are delighted to announce that the Physical Chemistry Chemical Physics (PCCP) themed collection Photodissociation and reaction dynamics is now online and free to access until 1 October 2019.. Guest-edited by Andrew Orr-Ewing (University of Bristol), this themed issue highlights the latest research in the fundamental mechanisms of photochemical and chemical reactions in the gas and liquid phases, featuring both experimental and theoretical studies. ...
The themed issue, Catalysis in Flow Chemistry, guest-edited by Steven Ley (University of Cambridge), features key contributions on the use of catalysis in flow chemistry applications. This important developing area of science encompasses homogeneous, heterogeneous and enigmatic systems, with an emphasis on using continuous flow based technologies.. Read the full themed collection here. ...
Tamoxifen-inducible genetic inactivation of cannabinoid type 1 (CB1) receptor in TPH2-positive neurons. (A) Schematic illustrations of CB1fl/fl allele before (a
Abstract The possible role of the CB2 receptor (CB2r) in psychiatric disorders has been considered. Several animal models use knockout (KO) mice that...
THCV is a cannabinoid that has garnered much attention for its ability to suppress appetite. The obscure compound is explored and explained in this post.
4-cyano-1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide: a CB1 cannabinoid receptor radioligand for PET imaging
Pharmaxis in Australia was actively engaged in a research programme focused on developing orally-available, synthetic selective cannabinoid receptor ligands,
A list of the journals that are reviewed and the criteria for selecting articles from these journals for inclusion in Evidence-Based Nursing are included in each issue. The following articles passed all criteria but were not abstracted because, in the judgment of the editors, their findings were less widely applicable to nursing practice, the topic was of interest to only a select group of nurse specialists, or the topic was recently addressed in another abstract. ...
A list of the journals that are reviewed and the criteria for selecting articles from these journals for inclusion in Evidence-Based Nursing are included in each issue. The following articles passed all criteria but were not abstracted because, in the judgment of the editors, their findings were less widely applicable to nursing practice, the topic was of interest to only a select group of nurse specialists, or the topic was recently addressed in another abstract. ...
The Kidney Dialysis Foundation (KDF) is a non-profit charitable organisation that provides subsidised dialysis treatment to needy members of our community.
http://gerrit.cloudera.org:8080/4535 to look at the new patch set (#2). Change subject: cache: fix behavior on single-CPU systems ...................................................................... cache: fix behavior on single-CPU systems On a system with only a single CPU, shard_bits_ would be set to 0. This would then result in calculating hash ,, (32 - 0) which is undefined behavior. With optimizations, this would turn into a no-op, and wed end up using the whole hash as the shard index, instead of 0, causing a crash. The fix is to widen the hash to uint64_t before shifting. Tested by manually making NumCPUs return 1 and running cache-test. Change-Id: I7809e5697df657a589b2ceae5c6d4edbf161b52a --- M src/kudu/util/cache.cc 1 file changed, 3 insertions(+), 1 deletion(-) git pull ssh://gerrit.cloudera.org:29418/kudu refs/changes/35/4535/2 -- To view, visit http://gerrit.cloudera.org:8080/4535 To unsubscribe, visit http://gerrit.cloudera.org:8080/settings Gerrit-MessageType: newpatchset ...
Bikramjeet Vig has posted comments on this change. ( http://gerrit.cloudera.org:8080/8233 ) Change subject: IMPALA-6002: Add a LLVM diagnostic handler for LLVM linker errors ...................................................................... Patch Set 3: (1 comment) http://gerrit.cloudera.org:8080/#/c/8233/1/tests/query_test/test_codegen.py File tests/query_test/test_codegen.py: http://gerrit.cloudera.org:8080/#/c/8233/1/tests/query_test/[email protected] PS1, Line 45: def test_codegen_diagnostic_handler(self, vector): , You could probably test this in be/src/codegen/llvm-codegen-test.cc with co Done -- To view, visit http://gerrit.cloudera.org:8080/8233 To unsubscribe, visit http://gerrit.cloudera.org:8080/settings Gerrit-Project: Impala-ASF Gerrit-Branch: master Gerrit-MessageType: comment Gerrit-Change-Id: I907ff1f8975c02d422b4a669afbfc2e536ddf1ff Gerrit-Change-Number: 8233 Gerrit-PatchSet: 3 Gerrit-Owner: Bikramjeet Vig ,[email protected], Gerrit-Reviewer: Bikramjeet Vig ...
Patch Set 6: Build Started http://104.196.14.100/job/kudu-gerrit/2560/ -- To view, visit http://gerrit.cloudera.org:8080/3645 To unsubscribe, visit http://gerrit.cloudera.org:8080/settings Gerrit-MessageType: comment Gerrit-Change-Id: I331f2d5bb06c38daa7b09854dbb24a7881723551 Gerrit-PatchSet: 6 Gerrit-Project: kudu Gerrit-Branch: master Gerrit-Owner: Adar Dembo ,[email protected], Gerrit-Reviewer: Adar Dembo ,[email protected], Gerrit-Reviewer: Dan Burkert ,[email protected], Gerrit-Reviewer: Kudu Jenkins Gerrit-Reviewer: Mike Percy ,[email protected], Gerrit-Reviewer: Todd Lipcon ,[email protected], Gerrit-HasComments: No ...
and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions and entirely new research, and to encourage better communication among scientists as well as between the scientific community and the public. For more information about NAKFI, please visit http://www.keckfutures.org. For more information about the W.M. Keck Foundation, please visit http://www.wmkeck.org. ...
Tetra BioPharma is developing a cannabinoid based therapeutics, acting by inhibition of the hedgehog signalling pathway, for the treatment of cancer and ocular
Amyris, Inc. (Nasdaq: AMRS), a leader in the development and production of sustainable ingredients for the Health & Wellness, Clean Beauty and Flavors & Fragrances markets, today reported that it has successfully shipped the first cannabinoid to its partner, LAVVAN. Amyris is also well on its way to
NEW YORK, September 13, 2017 /PRNewswire/ -- Biosynthesis Technology Could Transform Cannabinoid Production. NetworkNewsWire Editorial Coverage.
Sigma-Aldrich offers abstracts and full-text articles by [Patricia Rivera, Sergio Arrabal, Manuel Cifuentes, Jesús M Grondona, Margarita Pérez-Martín, Leticia Rubio, Antonio Vargas, Antonia Serrano, Francisco J Pavón, Juan Suárez, Fernando Rodríguez de Fonseca].
Alcohol Clin Exp Res. 2011 Jan;35(1):19-27. doi: 10.1111/j.1530-0277.2010.01318.x. Epub 2010 Oct 19. Research Support, N.I.H., Extramural
Shop for fall themed paper at Creative Memories with the Hello, Autumn collection. Includes 12 sheets of 12x12 paper with tonal designs of plaid and leaf tips.
If a players starting force is a named themed team, it can use TTPC. TTPC allows characters on that force to use Probability Control, up to X total times per game for that force. X is equal to the number of characters with the chosen keyword on that starting force, with a maximum of 5. In addition, a character using TTPC ...