The receptor activator of nuclear factor-kappa B ligand (RANKL)/receptor activator of nuclear factor-kappa B (RANK)/osteoprotegerin (OPG) system is the final common pathway for bone resorption. Osteob... more
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene. RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. Variation in concentration levels of RANKL throughout several organs, reconfirm ...
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Trance Maniacs Party: Uplifting Breeze #53 (2013) Uplifting Trance | 3Lime Rec. 320 kbps | MP3 | unmixed | 27-09-2013 | 03:04:34 | 433 Mb Uploaded: turbobit.net, rapidgator.net, uploaded.net
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The importance of RankL as a key osteoclastogenic factor in bone remodeling is now well established (63). Perhaps most persuasive is the finding through deletion studies in mice that the loss of either RankL or its receptor (Rank) results in a significant deficiency in osteoclast production (20, 37). Indeed, several osteoporotic states in humans have been ascribed to genetic defects in the RANKL/RANK/OPG signaling pathway (68). Thus, although factors separate from RankL are known to play roles in the osteoclastogenic process (35, 63), it is clear that this gene product and its signal transduction pathway are key components. An understanding of the mechanisms whereby this gene is regulated is therefore of paramount importance.. Our studies using ChIP/chip analysis, direct ChIP, and more traditional molecular approaches identified five distinct regions located at significant distances upstream of the TSS that were responsible for regulating the expression of the RankL gene. VDR and RXR localize to ...
TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
Sigma-Aldrich offers abstracts and full-text articles by [Gary J Spencer, Jennifer C Utting, Sharon L Etheridge, Timothy R Arnett, Paul G Genever].
VA - Trance Maniacs Party: Melody Of Heartbeat #58 (04.07.2011) Release: 2011 | MP3 | 320 kbps | 44100 Hz | Joint Stereo | 400 MB Genre: Vocal Trance VA - Trance Maniacs Party: Melody Of Hea
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La principale via regolatrice del metabolismo osseo è quella del Receptor Activator Nuclear Factor Kappa B Ligand (RANKL), anche noto come CD254. Questo ligando esiste sia in forma solubile sia di membrana (CD254). Il CD254 è espresso soprattutto dagli Osteoblasti (OBs), le cellule responsabili della formazione dellosso, mentre il suo recettore, RANK, dagli Osteoclasti (OCs), le cellule deputate al riassorbimento. Gli osteoclasti degradano losso dopo lattivazione attraverso il legame del RANKL. Altre cellule possono esprimere il RANKL e lalta espressione del RANKL è associata alla capacità delle cellule di indurre osteolisi. Lanalisi al citofluorimetro ha dimostrato che lespressione della forma di membrana CD254 è up-regolata nei pazienti allesordio B LLA Common rispetto ai controlli fuori terapia o a fine mantenimento. Mediante esperimenti di co-cultura è stata studiata la capacità dei blasti di influenzare il differenziamento dei precursori degli osteoclasti. E stata valutata ...
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species ...
in Clinical & Experimental Immunology (2004), 138(3), 491-498. Crohns disease (CD) is associated with low bone mass due to chronic inflammation and other factors. Receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor ... [more ▼]. Crohns disease (CD) is associated with low bone mass due to chronic inflammation and other factors. Receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor osteoprotegerin (OPG) are potentially involved in this process as they regulate osteoclastogenesis and are influenced by pro-inflammatory cytokines. The aim of this study was to determine the levels of soluble RANKL (sRANKL), RANK and OPG expression both in the serum and in the colon of CD patients. Levels of sRANKL and OPG were assessed in the serum and the supernatants of cultured colonic biopsies in patients with CD and controls by ELISA. RANK expression was explored by immunostaining and immunofluorescence of fixed colonic samples. OPG and ...
Recent works demonstrated the difference of calcification genesis between carotid and femoral plaques, femoral plaques being more calcified. It has been clearly demonstrated that the molecular triad osteoprotegerin (OPG)/Receptor Activator of NFkB (RANK)/RANK Ligand (RANKL) exerts its activities in the osteoimmunology and vascular system. The aim of this study was to determine their expression and their potential role in calcifications of the atheromatous plaques located in two different peripheral arterial beds, carotid and femoral. The expression of OPG, RANK and RANKL was analyzed by immunochemistry in 40 carotid and femoral samples. Blood OPG and RANKL were quantified using specific ELISA assays. OPG staining was more frequently observed in carotid than in femoral plaques, especially in lipid core. Its expression correlated with macrophage infiltration more abundantly observed in carotid specimens. Surprisingly, serum OPG concentration was significantly lower in carotid population compared to
Receptor activator of NF-kappaB ligand (RANKL), its signaling receptor RANK, and its decoy receptor osteoprotegerin (OPG) constitute a molecular triad that is critical in regulating bone remodeling, and also plays multiple roles in the immune system. OPG binds RANKL directly to block its interaction with RANK. In this article, we report the 2.7-A crystal structure of human RANKL trimer in complex with the N-terminal fragment of human OPG containing four cysteine-rich TNFR homologous domains (OPG-CRD). The structure shows that RANKL trimer uses three equivalent grooves between two neighboring monomers to interact with three OPG-CRD monomers symmetrically. A loop from the CRD3 domain of OPG-CRD inserts into the shallow groove of RANKL, providing the major binding determinant that is further confirmed by affinity measurement and osteoclast differentiation assay. These results, together with a previously reported mouse RANKL/RANK complex structure, reveal that OPG exerts its decoy receptor function ...
Context: Prostate cancer (PCa) cells are characterised by an exquisite tropism for the bone, which translates into one of the highest rates of bone metastases and skeletal morbidity. New, effective treatments have emerged from a better understanding of the physiopathology of bone metastases. Objective: To summarise current insights and future perspectives in the therapy of PCa-induced bone disease. Evidence acquisition: This manuscript is based on presentations given at a satellite symposium held at the 2nd World Congress on Controversies in Urology (CURy) in Lisbon, Portugal. Data were retrieved from original and recent review papers on PCa-induced bone disease. Evidence synthesis: In normal, healthy bone, there is a balance between bone resorption and bone formation through the coordinated activity of osteoclasts and osteoblasts. The receptor activator of nuclear factor-kappa B ligand (RANKL) is an essential mediator of osteoclast formation, function, and survival. The RANKL pathway represents ...
TY - JOUR. T1 - Down-regulation of osteoprotegerin expression as a novel biomarker for colorectal carcinoma. AU - Kim, Hyun Soo. AU - Yoon, Gun. AU - Do, Sung Im. AU - Kim, Sung Joo. AU - Kim, Youn Wha. PY - 2016/3/22. Y1 - 2016/3/22. N2 - A better understanding of tumor biology is important in the identification of molecules that are down-regulated in malignancy and in determining their role in tumor suppression. The aim of this study was to analyze osteoprotegerin (OPG) expression in colorectal carcinoma (CRC) and to investigate the underlying mechanism for changes in the expression of OPG. OPG expression was assessed in CRC tissue samples and cell lines. The methylation status of the OPG promoter region was determined, and the effects of demethylation on OPG expression were analyzed. The effects of recombinant OPG (rOPG) administration on cellular functions were also investigated. Clinical and prognostic implications of OPG protein expression in CRC patients were analyzed. The CRC tissues and ...
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TY - JOUR. T1 - Novel inhibitors of RANKL-induced osteoclastogenesis. T2 - Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones. AU - Lee, Chia Chung. AU - Liu, Fei Lan. AU - Chen, Chun Liang. AU - Chen, Tsung Chih. AU - Liu, Feng Cheng. AU - Ahmed Ali, Ahmed Atef. AU - Chang, Deh Ming. AU - Huang, Hsu Shan. PY - 2015/7/23. Y1 - 2015/7/23. N2 - A series of novel 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives were synthesized and evaluated for their inhibitory effects on osteoclast activities by using TRAP-staining assay. Among the tested compounds, 3d and 3h exhibited more potent osteoclast-inhibitory activities than the lead compound NDMC503 (a ring-fused structure of NDMC101), as reported in our previous study. Both 3d and 3h exhibited two-fold increase in activity compared to NDMC503. In addition, our biological results indicated that 3d and 3h could suppress RANKL-induced ...
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
In this report we investigated the role of the newly described TNF-related protein, OPGL, in OC activation. Previously, Lacey et al. (1998) and Yasuda et al. (1998b) identified OPGL/ODF as the long sought OC differentiation factor. Direct expression cloning was used independently by the two groups to identify OPGL/ODF as the ligand for OPG/OCIF. OPG is expressed only as a soluble form and is now believed to act as a soluble decoy receptor to regulate the action of OPGL on differentiation of OCs. The data presented in the two reports provide strong evidence that OPGL acts directly on a population of OC progenitors, and together with CSF-1 induces terminal differentiation into mature, active OCs. Our data also showed that OPGL activated mature OCs to resorb bone in vitro (Lacey et al., 1998), and recent work supports our previous results (Fuller et al., 1998).. In this report we have shown that OPGL or agonist antibodies to its receptor, RANK, act directly on fully differentiated, mature OCs ...
Receptor Activator of NF-?B Ligand (RANKL) is a cell-bound marker (CD254) related to the TNF family of proteins. RANKL plays a critical role in bone metabolism, particularly osteoclast differentiation. In addition, RANKL is expressed by some T cells and i
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Trance In France cest quoi ? «Trance In France» est une organisation leader en France dans le domaine de la Trance Music (musique club et évènementielle). La marque a été lancée en 2006 par le disc-jockey Tom Neptunes en réponse au manque de présence de musiques Trance sur le sol français en lui offrant un relai médiatique et un moyen daction. «Trance In France» développe et fédère un réseau regroupant des Djs, des agences, des clubs, des événements, des médias, des fans, et dautres acteurs, autour de son nom.
This seminar, presented by Miguel Tam, Senior Product Manager, discusses addressing cancer research using multiple techniques and tools. Specifically, he addresses |em|in vitro|/em| models for characterizing melanoma RANK- RANKL interactions, such as cell migration, intracellular signaling, and immunofluorescence microscopy. PD-L1 blocking antibodies are also investigated in an in vivo mouse model, subsequently examined by T cell activation, cytokine and chemokine production, tumor specific T cells, and tumor growth.
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Abcams Osteoprotegerin ELISA Kit suitable for Cell culture supernatant, Serum, Plasma, Cell Lysate in human. Reliably quantify 1 pg/ml of Osteoprotegerin.
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Apoptosis, or programmed cell death, is a normal component of cellular differentiation and the development of multicellular organisms. Receptor activator ofNF-kB (RANK) lacks significant homology with the other family members of the tumor necrosis factor
There are no specific protocols for Recombinant human Osteoprotegerin protein (ab73829). Please download our general protocols booklet
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TRANCE/TNFSF11/RANK L Antibody Pair. Matched antibody pairs validated for ELISA or IP-Western Blot. Backed by our 100% Guarantee.
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Comfortable around sharks? How about stroking and holding one until it lulls into a trance so profound, you can hold it vertically by the nose. Italian diver Cristina Zenato does just that in her work... Science News Summaries. | Newser
DJ Basilisk - Circadian Rhythms (2012) Deep Trance, Goa | Basilisk 320 kbps | MP3 | mixed | 25 Jan 2012 | 01:34:52 | 173 Mb Uploaded: turbobit.net, ul.to, depositfiles.com DJ Basilisk - C
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This is where Radio Shows and Guest Mixes played on 1Mix are listed. You will find Track Listings and comments here.. Please feel free to comment and give us your feeback ...
This is where Radio Shows and Guest Mixes played on 1Mix are listed. You will find Track Listings and comments here.. Please feel free to comment and give us your feeback ...
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OBJECTIVE: Osteoprotegerin ligand (OPGL) is a newly discovered molecule, which is expressed by osteoblasts/bone stromal cells. This ligand and M-CSF are now known to be essential for osteoclast differentiation from marrow and circulating precursors. This study examined whether OPGL and its soluble receptor osteoprotegerin (OPG), influenced osteoclast formation from human arthroplasty derived macrophages, to determine if the effects of OPGL and OPG on these cells could contribute to the osteolysis of aseptic loosening. METHODS: OPGL (+/- dexamethasone/M-CSF) was added to cultures of macrophages isolated from the pseudomembrane of loosened hip arthroplasties incubated on glass coverslips and dentine slices. OPG was added to cocultures of arthroplasty derived macrophages and UMR106 osteoblast-like cells. Osteoclast differentiation in long term cultures was assessed by expression of macrophage (CD14) and osteoclast markers (tartrate resistant acid phosphatase (TRAP), vitronectin receptor (VNR) and lacunar