TY - JOUR. T1 - Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats. AU - Shimabukuro, Michio. AU - Zhou, Yan Ting. AU - Lee, Young H. AU - Unger, Roger H. PY - 1997/8/18. Y1 - 1997/8/18. N2 - Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.. AB - Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese ...
TY - JOUR. T1 - Pressor recovery after acute stress is impaired in high fructose-fed Lean Zucker rats. AU - Thompson, Jennifer A.. AU - DAngelo, Gerard. AU - Mintz, James D.. AU - Fulton, David J.. AU - Stepp, David W.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Insulin resistance is a powerful predictor of cardiovascular disease; however, the mechanistic link remains unclear. This study aims to determine if early cardiovascular changes associated with short-term fructose feeding in the absence of obesity manifest as abnormal blood pressure control. Metabolic dysfunction was induced in Lean Zucker rats by short-term high-fructose feeding. Rats were implanted with telemetry devices for the measurement of mean arterial blood pressure (MAP) and subjected to air jet stress at 5 and 8 weeks after feeding. Additional animals were catheterized under anesthesia for the determination of MAP and blood flow responses in the hind limb and mesenteric vascular beds to intravenous injection of isoproterenol ...
Marsh, Susan, A., Powell, Pamela, C., Agarwal, Anupam, DellItalia, Louis, J. and Chatham, John, C. (2006). Cardiovascular dysfunction is caused by pre-existing hydronephrosis in young lean, obese and diabetic Zucker rats. In: The FASEB Journal. Experimental Biology 2006 Meeting, San Francisco, CA, (A298-A298). 1-5 April, 2006. ...
Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventricle (LV). The mechanisms responsible are incompletely known and no specific treatment is presently defined. We evaluated the possible usefulness of two molecules promoting lipid oxidation, fenofibrate and metformin, in an experimental model of DCM, the Zucker diabetic rat (ZDF). ZDF and controls (C) rats were studied at 7, 14 and 21 weeks. After an initial study at 7 weeks, ZDF rats received no treatment, metformin or fenofibrate until final studies (at 14 or 21 weeks). C rats received no treatment. Each study comprised measurements of metabolic parameters (plasma glucose, TAG, insulin levels) and sampling of heart for histology and measurements of TAG content and relevant mRNA concentration. ZDF rats were insulin-resistant at 7 weeks, type 2 diabetic at 14 weeks and diabetic with insulin
Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventricle (LV). The mechanisms responsible are incompletely known and no specific treatment is presently defined. We evaluated the possible usefulness of two molecules promoting lipid oxidation, fenofibrate and metformin, in an experimental model of DCM, the Zucker diabetic rat (ZDF). ZDF and controls (C) rats were studied at 7, 14 and 21 weeks. After an initial study at 7 weeks, ZDF rats received no treatment, metformin or fenofibrate until final studies (at 14 or 21 weeks). C rats received no treatment. Each study comprised measurements of metabolic parameters (plasma glucose, TAG, insulin levels) and sampling of heart for histology and measurements of TAG content and relevant mRNA concentration. ZDF rats were insulin-resistant at 7 weeks, type 2 diabetic at 14 weeks and diabetic with insulin
Male Zucker diabetic fatty (ZDF) rats were used to study effects of oral administration of interferon tau (IFNT) in reducing obesity. Eighteen ZDF rats (28 days of age) were assigned randomly to receive 0, 4, or 8 μg IFNT/kg body weight (BW) per day (n = 6/group) for 8 weeks. Water consumption was measured every two days. Food intake and BW were recorded weekly. Energy expenditure in 4-, 6-, 8-, and 10-week-old rats was determined using indirect calorimetry. Starting at 7 weeks of age, urinary glucose, and ketone bodies were tested daily. Rates of glucose and oleate oxidation in liver, brown adipose tissue, and abdominal adipose tissue, as well as leucine catabolism in skeletal muscle, and lipolysis in white and brown adipose tissues were greater for rats treated with 8 μg IFNT/kg BW/day in comparison with control rats. Treatment with 8 μg IFNT/kg BW/day increased heat production, reduced BW gain and adiposity, ameliorated fatty liver syndrome, delayed the onset of diabetes, and decreased ...
Earlier we have reported that the inhibitory effects of dopamine on NKA and NHE activities in proximal tubules of hyperinsulinemic obese rats were significantly reduced compared with lean rats. We also observed that the reduced inhibition of these transporters was associated with a significant reduction in D1 receptor number in proximal tubular membranes of obese rats. In the present study, we found that if plasma levels of insulin were lowered in obese rats, the ability of dopamine to inhibit the sodium transporters in proximal tubules was restored and membrane D1 receptor numbers were normalized to the level as in lean rats.. Dopamine, endogenously produced or exogenously infused, activates tubular D1 dopamine receptors, leading to the inhibition of sodium transporters, involving multiple second-messenger pathways and subsequently causes an increase in sodium excretion.1 There have been reports suggesting a negative correlation between renal dopaminergic function and plasma insulin ...
Gastrointestinal bypass surgeries that result in rerouting and subsequent exclusion of nutrients from the duodenum appear to rapidly alleviate hyperglycemia and hyperinsulinemia independent of weight loss. While the mechanism(s) responsible for normalization of glucose homeostasis remains to be fully elucidated, this rapid normalization coupled with the well-known effects of vagal inputs into glucose homeostasis suggests a neurohormonally mediated mechanism. Our results show that duodenal bypass surgery on obese, insulin-resistant Zucker fa/fa rats restored insulin sensitivity in both liver and peripheral tissues independent of body weight. Restoration of normoglycemia was attributable to an enhancement in key insulin-signaling molecules, including insulin receptor substrate-2, and substrate metabolism through a multifaceted mechanism involving activation of AMP-activated protein kinase and downregulation of key regulatory genes involved in both lipid and glucose metabolism. Importantly, while ...
The pentose phosphate pathway (PPP) is widely assumed to play a key role in both reductive biosynthesis and protection from oxidative stress because it is the major source of NADPH. However, little is known about the activity of the PPP in fatty liver which is characterized by both oxidative stress and lipogenesis. This study was designed to test whether the PPP is active in parallel with lipogenesis and antioxidant processes in the fatty liver of whole animals. Eight- and 16-week old, obese Zucker diabetic fatty rats and their lean littermates received [U-13C3]glycerol, and 13C labeling patterns of glucose and triglycerides were analyzed for the assessment of hepatic PPP activity and the potentially-related processes simultaneously ...
The pentose phosphate pathway (PPP) is widely assumed to play a key role in both reductive biosynthesis and protection from oxidative stress because it is the major source of NADPH. However, little is known about the activity of the PPP in fatty liver which is characterized by both oxidative stress and lipogenesis. This study was designed to test whether the PPP is active in parallel with lipogenesis and antioxidant processes in the fatty liver of whole animals. Eight- and 16-week old, obese Zucker diabetic fatty rats and their lean littermates received [U-13C3]glycerol, and 13C labeling patterns of glucose and triglycerides were analyzed for the assessment of hepatic PPP activity and the potentially-related processes simultaneously ...
This study was undertaken to determine whether receptor and non-receptor components of the adenylate cyclase (AC) cascade were altered in brown adipose tissue (BAT) of 14-day-old pre-obese (fa/fa) rats, before endocrine status is strongly modified by fa gene expression. Activity of the AC catalytic subunit did not differ between the two genotypes. In fa/fa rats compared with control Fa/fa rats, there was a 50% decrease in the activity of alpha Gs (stimulated by NaF or guanosine 5′-[gamma-thio]triphosphate) but no change in protein content (Western blotting). alpha Gi function, assessed by the inhibitory action of low concentrations of guanosine 5′-[beta gamma-imido]triphosphate upon 10(-4) M forskolin-stimulated AC activity, was equally low in both genotypes. Analysis of dose-response curves for different beta-agonists revealed that (i) both the basal and the maximally stimulated activity of AC were 2-fold lower in fa/fa rats than in Fa/fa rats; (ii) BRL37344 and CGP12177 (beta 3 agonists) ...
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type 2 diabetes mellitus (T2DM) is a disease characterized by persistent and progressive deterioration of glucose tolerance that is associated with loss of glucose effectiveness and development of insulin resistance (21, 27). The effectiveness of glucose refers to the ability of glucose per se to function as a negative feedback regulator in determination of blood glucose levels (6). In nondiabetic subjects, an acute rise in plasma glucose increases insulin secretion from pancreatic β-cells and via a mass action of glucose per se exerts an inhibitory effect on glucose production while stimulating glucose uptake (6, 42). On the other hand, patients with established T2DM fail to respond normally to elevated plasma glucose and/or insulin, resulting in impaired glucose uptake in peripheral tissues and a failure to suppress net hepatic glucose production (NHGP), both of which contribute to fasting hyperglycemia (13, 27). In addition, a defect in splanchnic glucose uptake accompanied by reduced ...
1. Intragastric feeding (40 kJ) produced a 17% rise in metabolic rate in lean Zucker rats but only an 8% increase in obese (fa/fa) rats, and both of these responses were significantly reduced by...
An incretin hormone, glucagon-like peptide-1 (GLP-1), has been shown to lower plasma glucose via glucose-dependent insulin secretion and to reduce appetite. We previously found that the biguanide metformin, an antidiabetic agent, causes a significant increase of plasma active GLP-1 level in the presence of dipeptidyl peptidase IV (DPPIV) inhibitor in normal rats. This finding suggested that the combination treatment might produce a greater antidiabetic and anorectic effect, based on enhanced GLP-1 action. In this study, we assessed the effects of subchronic treatment with metformin and a DPPIV inhibitor, valine-pyrrolidide (val-pyr), on glycemic control, food intake, and weight gain using Zucker fa/fa rats, a model of obesity and impaired glucose tolerance. The combination treatment caused a significant increase of GLP-1 level in Zucker fa/fa rats. In a subchronic study, val-pyr, metformin, or both compounds were administered orally b.i.d. for 14 days. The combination treatment significantly ...
Many theories have been advanced to better understand why β cell function and structure relentlessly deteriorate during the course of type 2 diabetes (T2D). These theories include inflammation, apoptosis, replication, neogenesis, autophagy, differentiation, dedifferentiation, and decreased levels of insulin gene regulatory proteins. However, none of these have considered the possibility that endogenous self-repair of existing β cells may be an important factor. To examine this hypothesis, we conducted studies with female Zucker diabetic fatty rats fed a high-fat diet (HFD) for 1, 2, 4, 7, 9, 18, or 28 days, followed by a return to regular chow for 2-3 weeks. Repair was defined as reversal of elevated blood glucose and of inappropriately low blood insulin levels caused by a HFD, as well as reversal of structural damage visualized by imaging studies. We observed evidence of functional β cell damage after a 9-day exposure to a HFD and then repair after 2-3 weeks of being returned to normal chow ...
Many theories have been advanced to better understand why β cell function and structure relentlessly deteriorate during the course of type 2 diabetes (T2D). These theories include inflammation, apoptosis, replication, neogenesis, autophagy, differentiation, dedifferentiation, and decreased levels of insulin gene regulatory proteins. However, none of these have considered the possibility that endogenous self-repair of existing β cells may be an important factor. To examine this hypothesis, we conducted studies with female Zucker diabetic fatty rats fed a high-fat diet (HFD) for 1, 2, 4, 7, 9, 18, or 28 days, followed by a return to regular chow for 2-3 weeks. Repair was defined as reversal of elevated blood glucose and of inappropriately low blood insulin levels caused by a HFD, as well as reversal of structural damage visualized by imaging studies. We observed evidence of functional β cell damage after a 9-day exposure to a HFD and then repair after 2-3 weeks of being returned to normal chow ...
The obesity epidemic in the US has continued for over two decades as the proportion of overweight and obese adults in the population continues to rise. ..
In growing male obese Zucker rats, hyperphagia reaches a maximum or "breakpoint" and declines at an earlier age with high fat than with chow-type diets. A serial adipose tissue biopsy technique was used to correlate changes of retroperitoneal adipocyte size and feeding behavior in 5- to 7-wk-old male lean and obese rats fed laboratory chow or a 35% fat diet until 30 wk of age. Although chow-fed groups had significantly greater cumulative intake, fat-fed groups had significantly greater body weight gain, retroperitoneal depot weight, and adipocyte number. Mean adipocyte size increased continuously in chow-fed groups but decreased over weeks 20-30 in fat-fed groups, reflecting increased adipocyte number. In fat-fed obese rats, hyperphagia reached a breakpoint at 11 wk and disappeared by 13 wk. In chow-fed obese rats, hyperphagia reached a breakpoint at 15-16 wk and disappeared by 19 wk. Biopsy samples revealed that adipocyte size of fat-fed obese rats was already close to maximal at 10 wk (1.12 ...
In growing male obese Zucker rats, hyperphagia reaches a maximum or "breakpoint" and declines at an earlier age with high fat than with chow-type diets. A serial adipose tissue biopsy technique was used to correlate changes of retroperitoneal adipocyte size and feeding behavior in 5- to 7-wk-old male lean and obese rats fed laboratory chow or a 35% fat diet until 30 wk of age. Although chow-fed groups had significantly greater cumulative intake, fat-fed groups had significantly greater body weight gain, retroperitoneal depot weight, and adipocyte number. Mean adipocyte size increased continuously in chow-fed groups but decreased over weeks 20-30 in fat-fed groups, reflecting increased adipocyte number. In fat-fed obese rats, hyperphagia reached a breakpoint at 11 wk and disappeared by 13 wk. In chow-fed obese rats, hyperphagia reached a breakpoint at 15-16 wk and disappeared by 19 wk. Biopsy samples revealed that adipocyte size of fat-fed obese rats was already close to maximal at 10 wk (1.12 ...
In growing male obese Zucker rats, hyperphagia reaches a maximum or "breakpoint" and declines at an earlier age with high fat than with chow-type diets. A serial adipose tissue biopsy technique was used to correlate changes of retroperitoneal adipocyte size and feeding behavior in 5- to 7-wk-old male lean and obese rats fed laboratory chow or a 35% fat diet until 30 wk of age. Although chow-fed groups had significantly greater cumulative intake, fat-fed groups had significantly greater body weight gain, retroperitoneal depot weight, and adipocyte number. Mean adipocyte size increased continuously in chow-fed groups but decreased over weeks 20-30 in fat-fed groups, reflecting increased adipocyte number. In fat-fed obese rats, hyperphagia reached a breakpoint at 11 wk and disappeared by 13 wk. In chow-fed obese rats, hyperphagia reached a breakpoint at 15-16 wk and disappeared by 19 wk. Biopsy samples revealed that adipocyte size of fat-fed obese rats was already close to maximal at 10 wk (1.12 ...
The loss of acute GSIS seen in the diabetic state is accompanied by marked changes in β-cell phenotype demonstrated by changes in gene and protein expression. These changes have been found in islets from both diabetic ZDF rats (28) and rats following partial pancreatectomy in which residual β-cells are exposed to varying degrees of hyperglycemia (29-32). The alterations may be thought of as dedifferentiation, or loss of phenotype, in that the highly expressed genes in β-cells (mentioned above) are downregulated while those that are normally suppressed are upregulated in their expression. Some of the upregulated genes include glucose-6-phosphatase, fructose-1,6-bisphosphatase, lactate dehydrogenase, and hexokinase. In addition, a stress response is found with a variety of antioxidant, apoptotic, and proapoptotic genes being activated (31). These are accompanied by a marked increase in the expression of c-myc and activation of nuclear factor (NF)-κB. These changes are consistent with a recent ...
Calories are like the accounting, they may keep a record of the past, but contribute little in the management of the body weight. (but everything is negative) If a company was loosing money, the first thing to go would be the non-essential loss leaders. Each product has a separate gross profit, just as foods. I equate carbohydrates to the loss leaders. They provide a high contribution to the fat building through hyperinsulinemia. After that, we need to look at the quantities both fat and proteins. The fats can contribute to fat growth, but on the whole, we do not need that much of them while we lose weight ...
Note that satiety is just post meal, not duration between meals. It is the space between meals that fat provides that allow us to use calories up. Note that when the C/t, calories divided by time, to the next meal is less that your BMR, base metabolism rate, we are loosing weight. That is a test before lunch and before supper. (meals of this size cannot be called dinner) Satiety is at the end of the meal, our ability to push away from the table. Early nights, early rises may also help ...
Rigorous Honesty, in the search of recovery from gross obesity. Mainly opinion, not advice. Some speculation, some errors, some fiction. Sugar, grain and processed products are not food. Omega 6 oil and dairy should be mainly avoided. ...
semitism nedir ve semitism ne demek sorularına hızlı cevap veren sözlük sayfası. (semitism anlamı, semitism türkçesi, semitism nnd)
cicoz nedir ve cicoz ne demek sorularına hızlı cevap veren sözlük sayfası. (cicoz anlamı, cicoz ingilizcesi, ingilizcede cicoz, cicoz nnd)
Kocaman bir yalnızlığın sonucudur evlilik genellikle. Kendimden örnek verecek olursam; askere gittiğim ilk zamanlar kendimi o kadar yalnız hissediyordum ki. Askerlik bitsin her ne olursa olsun evlenecem diyordu http://powerssquared.com/?sth=zolpidem-coupons ... ambien not helping sleep Read More... ...
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Biyoloji kelime öğrenmenin ve alıştırma yapmanın eğlenceli ve hızlı yolu. Anadili İNGİLİZCE (İNGİLİZ) olanlar için kurslar
Şişmanlık (Obezite), vücutta fazla miktarda yağ birikmesi sonucu ortaya çıkan ve mutlaka tedavi edilmesi gereken bir hastalıktır. Şişmanlık, genel olarak yaşam sürecini kısaltan, yaşam kalitesini olumsuz yönde etkileyen ve birçok önemli rahatsızlığa zemin hazırlayan bir hastalıktır. Şişmanlığın zararlarını şöyle sıralamak mümkündür;
★İşlenmiş gıdalarda alerjen tespit edilenibilir.(Özel özütleme çözeltisi ve benzersiz antikor ile) ★Çeşitli numuneler için uygundur. ★Kullanımı kolay ve hızlı test
Actidem urup; ks r k, alerjik nezle ve bir enfeksiyon veya alerji olmaks z n burunda olu an t kanma (vazomotor nezle) gibi rahats zl klar n tedavisinde etkili
Serkan zt rk, Mehmet zya ar, Selim Suzi Ayhan, Mehmet Fatih zl , Alim Erdem, Aytekin Al elik, Sel uk zt rk, Kemalettin Erdem, Mehmet Yaz c ...
TY - JOUR. T1 - Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups. AU - Kowalski, Timothy J.. AU - Houpt, Thomas A.. AU - Jahng, Jeongwon. AU - Okada, Nori. AU - Chua, Jr., Streamson C.. AU - Smith, Gerard P.. PY - 1998. Y1 - 1998. N2 - Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ hybridization. PreproNPY expression within the arcuate nucleus was localized to cells in the medial portion. Twenty-four hours of food, water, and maternal deprivation significantly increased the relative abundance of preproNPY mRNA in pups on postnatal day (P) 2, P9, P12, and P15 by 14-31%. This response, however, was not observed on ...
The present study was undertaken to determine whether the capacity for 3,5,3′,5′-tetraiodothyronine (T4) conversion into 3,5,3′-tri-iodothyronine (T3), as measured by the activity of thyroxine type II 5′-monodeiodinase (T4-5′D), was altered in the brains of young Zucker fa/fa rats during the period of intense maturation of the central nervous system (i.e. from 10 to 20 days of life). From 7 to 14 days of age, no difference in brain T4-5′D activity could be detected between lean and pre-obese rats; serum free T4 was not affected by the fa gene. During the suckling to weaning transition, T4-5′D reached a plateau in brains of lean rats, while it increased by 50% in brains of pre-obese rats; concurrently, serum free T4 increased in Fa/fa rats, whereas it did not change in fa/fa rats. The increased capacity for conversion of T4 into T3 observed in brains of pre-obese compared with lean rats could not be ascribed to a variation in the amount of T4-5′D, since Vmax. did not differ ...
TY - JOUR. T1 - Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus. AU - Lapa, Constantin. AU - Arias-Loza, Paula. AU - Hayakawa, Nobuyuki. AU - Wakabayashi, Hiroshi. AU - Werner, Rudolf A.. AU - Chen, Xinyu. AU - Shinaji, Tetsuya. AU - Herrmann, Ken. AU - Pelzer, Theo. AU - Higuchi, Takahiro. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by 18F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic 18F-FDG PET using a dedicated small animal PET system was performed under ...
1. According to the abstract of the study of "Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity" by Slavkovsky R, Kohlerova R, Tkacova V, Jiroutova A, Tahmazoglu B, Velebny V, Rezačová M, Sobotka L, Kanta J. (Source from Laboratory of Wound Healing, CPN, Dolni Dobrouc, Czech Republic. [email protected], Wound Repair Regen. 2011 Jul;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.), posted in PubMed, researcher indicated that The concentration of hydroxyproline in the GT of diabetic animals was significantly decreased to about one half when compared with the nondiabetic controls. The expression of interleukin-6, myeloperoxidase, stromelysin-1, and collagenase-3 was increased in the GT of diabetic rats on Day 10, while the expression of type I collagen and elastin was decreased. Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, ...
Obesity is associated with risk factors for cardiovascular disease, including insulin resistance, and can lead to cardiac hypertrophy and congestive heart failure. Here, we used the insulin-sensitizing agent rosiglitazone to investigate the cellular mechanisms linking insulin resistance in the obese Zucker rat heart with increased susceptibility to ischemic injury. Rats were treated for 7 or 14 days with 3 mg/kg per os rosiglitazone. Hearts were isolated and perfused before and during insulin stimulation or during 32 min low-flow ischemia at 0.3 ml small middle dot min(-1) small middle dot grams wet wt(-1) and reperfusion. D[2-(3)H]glucose was used as a tracer of glucose uptake, and phosphorus-31 nuclear magnetic resonance spectroscopy was used to follow energetics during ischemia. At 12 months of age, obese rat hearts were insulin resistant with decreased GLUT4 protein expression. During ischemia, glucose uptake was lower and depletion of ATP was greater in obese rat hearts, thereby significantly
The new hormone was found to stimulate insulin secretion from rat and human islet cells and protect islet cells in the presence of toxic, cell-killing factors used in the study.. The study, which was supported in part by JDRF, a global leader in type 1 diabetes research, appears in the July 3 issue of the journal Cell Metabolism.. The findings provide insight into the health and survival of beta cells, a type of islet cell that produces insulin to regulate sugar levels. The discovery could open pathways for further research toward prevention and treatments for type 1 diabetes and type 2 diabetes.. The researchers gave the hormone, TLQP-21 to Zucker Diabetic Fatty rats, which have a genetic propensity to develop type 2 diabetes. They saw a significant improvement in insulin and glucose (sugar) levels and less beta cell death in the treated animals.. "We think this finding is important because it is the first demonstration that TLQP-21 prevents deterioration of the beta cells and stimulates ...
TY - JOUR. T1 - Fatty diabetic lung. T2 - Functional impairment in a model of metabolic syndrome. AU - Yilmaz, Cuneyt. AU - Ravikumar, Priya. AU - Bellotto, Dennis J.. AU - Unger, Roger H. AU - Hsia, Connie C. PY - 2010/12/1. Y1 - 2010/12/1. N2 - The Zucker diabetic fatty (ZDF fa/fa) rat with genetic leptin insensitivity develops obesity and Type 2 diabetes mellitus (T2DM) with age accompanied by hyperplastic changes in the distal lung (Am J Physiol Lung Cell Mol Physiol 298: L392-L403, 2010). To determine the functional consequences of structural changes, we developed arebreathing (RB) technique to simultaneously measure lung volume, pulmonary blood flow, lung diffusing capacity (DlCo), membrane diffusing capacity (DmCo), pulmonary capillary blood volume (Vc), and septal tissue volume in anesthetized tracheostomized male ZDF fa/fa and matched lean (+/+) control animals at 4, 8, and 12 mo of age. Results obtained by RB technique were compared with that measured by a singlebreath (SB) technique ...
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In ZDF rat, a model of progressive development of T2D, characterized by insulin resistance and hyperglycemia, we analyzed whether the establishment of the disease was correlated with changes in liver mitochondrial function. Mitochondrial function was assessed in ZDF fa/fa rats at the age of 11 and 14 weeks as well as in normoglycemic - normoinsulinemic littermate control rats (ZDF lean fa/+). First, we observed no changes in mitochondrial respiration with G/M or Succinate between diabetic or nondiabetic rats. Surprisingly, palmitoyl‐carnitine driven mitochondrial respiration increases with the age in lean animals but not in diabetic rats, suggesting that the use of fatty acids could be impaired during the first weeks of the development of diabetes. Moreover, we reported an increase with age of the maximal uncoupled respiration with TMPD/Ascorbate in ZDF lean but not in diabetic animals, suggesting a lack of adaptation of the respiration in the latter. The main diabetes‐related difference in ...
In human diabetic patients, an excessive vasoconstrictive and pro-aggregatory thromboxane (TXA2) renal synthesis, along with a decrease in vasodilatory and anti-aggregatory prostaglandin (PGE2) synthesis, has been found to influence kidney function. Prostaglandins and thromboxane are formed by the enzymatic oxidation of arachidonic acid catalyzed by the cyclooxygenases, COX 1 and COX-2. Recently developed non-steroidal anti-inflammatory drugs (NSAIDS) are targeted to inhibit COX-2 and treat inflammation and arthritic pain. It is not known if the use of NSAIDS may be beneficial for the treatment of kidney disease; however, the upregulation of pro-inflammatory COX-2 and increased production of COX-2 derived metabolites have been implicated in diabetic nephropathy. COX-2 regulation and its association with renal damage are not known in the Obese Zucker rat. A new study tests the hypothesis that altered kidney regulation of COX-2 occurs at a very early stage in the progression of kidney disease ...
lac insect İngilizce - Türkçe Sözlük Çevirisini öğrenin. Ek olarak lac insect lak böcek çevirisinin detaylarını görün
In it is original, unmolested form, the 5th-gen Camaro ZL1 came out in 2011 packing GMs LSA 6.2-liter supercharged V8 producing 580HP (432 kW) and 556 lb-ft. of torque (754 Nm), making it the most powerful production Camaro at the time, a title it lost this year to the 6th gen Camaro ZL1 that comes with a 6.2-liter supercharged LT4 V8, good for 640hp (477 kW) and 640 lb-ft of torque (868 Nm)," according to Car Scoops.. ...
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Martin Holec, Máme tu 4x ze Zlína, co kdyby někdo jel do Brna pro 4ks a ve Zlíně by se rozdělili? Martin Šenkeřík, jak jsem psal, já do Zlína jezdívám, a od května do září budu ve Zlíně velmi často, takže se Zlínem není vůbec problém. Jinak už se objevily nějaké termíny. Jestli jsem to dobře pochopil, tak 9.5. by už mohla začít masová výroba a brzy na to by měl začít prodej... Pavel Kovář,, Jak by měl vlastně vypadat? Takový ten bíly se mně moc nelíbí. Radši bych měl černý. Michal Pěnka, Protože jsem jedenáctý a nevím, jestli bude možné objednat 11 kusů nebo jen po desítkách, domluvím se s Tomem Vargou později (jestli by byl ochotný pro převoz do Prahy), každopádně bych také raději ten černý. Pavel Kovář,, Jak to tak tady pročítám tak to půjde objednat za zvýhodněnou cenu (+pytlík? a headset) opravdu jenom po desítkách. Ale IMHO když této stránce zvedneme popularitu (případně přiberem Slováky) tak jich ...
Affiliation:聖マリアンナ医科大学,医学部,准教授, Research Field:Digestive surgery,Digestive surgery,Applied pharmacology, Keywords:N-acetylcysteine,Ischemia reperfusion,Proteomics,Zucker rat,DPD,neutrophil oxidative stress,α-glutathione-S-transferase,Ischemic preconditioning,還元型グルタチオン,テーラーメード医療, # of Research Projects:11, # of Research Products:30