Prediction of radiobiological response is a major challenge in radiotherapy. Of several radiobiological models, the linear-quadratic (LQ) model has been best validated by experimental and clinical data. Clinically, the LQ model is mainly used to estimate equivalent radiotherapy schedules (e.g. calculate the equivalent dose in 2 Gy fractions, EQD2), but increasingly also to predict tumour control probability (TCP) and normal tissue complication probability (NTCP) using logistic models. The selection of accurate LQ parameters α, β and α/β is pivotal for a reliable estimate of radiation response. The aim of this review is to provide an overview of published values for the LQ parameters of human tumours as a guideline for radiation oncologists and radiation researchers to select appropriate radiobiological parameter values for LQ modelling in clinical radiotherapy. We performed a systematic literature search and found sixty-four clinical studies reporting α, β and α/β for tumours. Tumour site,

A study to evaluate the efficacy of Intensity Modulated Radiation Therapy (IMRT) as compared to Standard Conventional Radiotherapy Alone in the treatment of carcinoma cervix. Concomitant Weekly Cisplatin chemotherapy will be given as a routine, which is a standard of care today for early stage cervical cancers including stage IIB. The benefits of using IMRT in reducing radiation-induced toxicity are well known. Since this treatment modality has not yet been validated and studied in a randomized trial setting, the present study is being undertaken. The study arm of IMRT has the potential to reduce the toxicities by 15-20%, but is associated with labor intense procedure requiring many hospital visits before actual start of treatment ...

75 years of tradition. The MediClin Robert Janker Clinic is a renowned clinic offering diagnostic radiology and neuroradiology as well as radiotherapy, and in particular high-precision radiotherapy, for the treatment of benign and malignant tumours. We use the latest medical procedures such as stereotactic radiotherapy and brachytherapy, providing our patients with the full spectrum of radiooncological treatment methods using ultramodern equipment.. Centre for high-precision radiotherapy. At the heart of the Radio-Oncological Department is a high-precision radiotherapy system that is available in only a handful of clinics in Germany. This pinpoint-precision machine represents the optimum solution for destroying the actual tumour whilst protecting as much of the surrounding tissue as possible. It even compensates for the tiniest of movements made by the patient during the treatment.. Stereotactic radio surgery (single high-dose radiotherapy) originates from the field of neurosurgery and is now ...

Health, ...COLLEGE PARK MD (June 24 2010) -- A meeting in Miami this week will ...Surgery radiation therapy and chemotherapy are the three main treatme...The meeting Safety in Radiation Therapy -- A Call to Action takes ... Radiation therapy provides safe and effective treatment of cancer and...,Miami,meeting,on,radiation,therapy,targets,patient,safety,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

The purpose of this study is to compare the toxicity of two new radiation schedules for the treatment of prostate cancer. Patients will be randomized to receive 5 treatments delivered every other day over 11 days, or once per week over 29 days. Both of these schedules are shorter than the standard treatment which is usually 39 treatments over 8 weeks ...

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients with Newly Diagnosed Glioblastoma - NCT02179086

External beam radiotherapy is one of the curative treatment options for localised prostate cancer. This article will describe recent advances in prostate radiotherapy, focussing on the results of randomised trials which have addressed the role of radiation dose escalation and of adjuvant hormone the …

OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials

Dr. Grigsby has done a masterful job of summarizing current information on the use of radiation in the management of patients with endometrial carcinoma. In the summary, he offers clear recommendations as to the appropriate management of various subsets of patients-recommendations that are based, at least to some extent, on the data reviewed. Such decision-making based on often incomplete information is necessary in the absence of appropriately designed randomized trials addressing the specific clinical situation. It is important, however, to understand clearly what we actually know and what we deduce from bits and pieces of data. 1

Objectives The clinical outcomes of patients treated with spatially fractionated GRID radiotherapy (SFGRT) for bulky tumors of the head and neck at a single institution were evaluated retrospectively. Endpoints of interest included tumor response, symptom improvement, treatment tolerance, and adverse events. Methods Institutional review board approval was obtained prior to study initiation. The institutional database was queried for patients with tumors of the head and neck treated with SFGRT between August 2007 and April 2015. Medical records of identified patients were reviewed for treatment details and clinical endpoints of interest. SFGRT was delivered in one fraction of 15 gray (Gy) or 20 Gy; 6 megavolt (MV) or 18 MV photon beams were passed through a multileaf collimator (MLC)-based or brass GRID template. All patients had a planned course of conventionally-fractionated external beam radiotherapy (EBRT) to begin on the day following SFGRT delivery. Results Twenty-one consecutive

More than half of all people with cancer are treated with radiation therapy. Get the facts on radiation therapy, including what it is, what to expect, and how to cope with side effects.

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TY - JOUR. T1 - Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer. AU - Cella, Laura. AU - DAvino, Vittoria. AU - Liuzzi, Raffaele. AU - Conson, Manuel. AU - Doria, Francesca. AU - Faiella, Adriana. AU - Loffredo, Filomena. AU - Salvatore, Marco. AU - Pacelli, Roberto. PY - 2013/9/23. Y1 - 2013/9/23. N2 - Background: The risk of radio-induced gastrointestinal (GI) complications is affected by several factors other than the dose to the rectum such as patient characteristics, hormonal or antihypertensive therapy, and acute rectal toxicity. Purpose of this work is to study clinical and dosimetric parameters impacting on late GI toxicity after prostate external beam radiotherapy (RT) and to establish multivariate normal tissue complication probability (NTCP) model for radiation-induced GI complications.Methods: A total of 57 men who had undergone definitive RT for prostate cancer were evaluated ...

The aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment planning using accurate dose calculation algorithms. A 9-field conformal treatment plan was generated on an inhomogeneous phantom with lung mimics and a soft tissue equivalent insert, mimicking a lung tumor. The dose distribution was calculated with the Pencil Beam and Collapsed Cone algorithms implemented in Masterplan (Nucletron) and the Monte Carlo system XVMC and validated using Gafchromic EBT films. Differences in dose distribution were evaluated. The plans were then optimized by adding segments to the outer shell of the target in order to increase the dose near the interface to the lung. The Pencil Beam algorithm overestimated the dose by up to 15% compared to the measurements. Collapsed Cone and Monte Carlo predicted the dose more accurately with a maximum difference of -8% and -3% respectively compared to the film. Plan

Introduction: External-beam radiation therapy boost is a treatment option in cervical cancer when brachytherapy is not feasible. Though less effective than brachytherapy, some encouraging results have been reported from some institutions experiences. We conducted this study to assess outcomes of EBRT boost for our patients at National Institute of Oncology in Rabat. Patients and Methods: We collected data from patients treated for cervical cancer between January 2012 and December 2015. Patients, tumor and treatment characteristics were collected. Overall survival (OS), disease-free survival (DFS) and prognostic factors influencing DFS were assessed. Results: One hundred and thirty-three patients were enrolled. Median age was 52 years. Patient haemoglobin level ranged from 3.9 to 15.5 g/dl [mean: 11.2 g/dl]. Most tumors were classified stage III/IVA (63.2%) according to the FIGO classification. Regional lymph node metastases (pelvic and or para-aortic) were observed in 45.1%. Median total dose to tumor

Dosimetric comparison of non-coplanar three-dimensional conformal radiation therapy (nc3DCRT) planning and radio biologically optimized partial arc volumetric modulated arc therapy (VMAT) planning of unilateral brain tumours - A retrospective study

ATLANTA - Intensity-modulated radiation therapy proved significantly better than conventional radiation for local control of soft-tissue sarcomas of the extremities, according to new study results, investigators reported at the annual meeting of the American Society for Radiation Oncology. The 5-year local control rate with intensity-modulated radiation therapy (IMRT) was 92.4%, compared with 85% for external-beam radiation therapy (EBRT), said Dr. Kaled M. Alektiar, a radiation oncologist at Memorial Sloan-Kettering Cancer Center in New York. The benefits of IMRT were seen despite a preponderance of higher risks in patients treated with IMRT. And, the morbidity profile, especially for chronic lymphedema of grade 3 or higher, was significantly less, Dr. Alektiar said. He and his coinvestigators looked at 320 patients who underwent definitive surgery and radiation therapy at Memorial Sloan-Kettering for primary, nonmetastatic soft-tissue sarcomas of the extremities. Of this group, 155 received ...

In the current study, we assessed the conventional BRT plan based on ICRU reference points and the CT-based BRT plan in patients with cervical cancer. We clearly demonstrated that tumor volume coverage was inadequate in the conventional plan compared to the CT-plan, and was inversely related with the volume of the target and the extension of tumor. With the conventional plan, the ICRU rectum and bladder point doses underestimated the actual rectum and bladder doses obtained from the CT-plan. Additionally, we demonstrated that more precise analysis of the dose received by certain volume of OARs can be accomplished by utilizing the DVHs on CT-plans, which may be of critical importance in regard to normal tissue tolerance limits.. After publication of ICRU 38 report, ICRU reference points for tumors, and reference dose points for bladder and rectum were used for defining the doses in conventional plans. But calculation of doses with these fixed reference points relative to applicators has certain ...

Photon Beam Dose Calculation Algorithms. Kent A. Gifford, Ph.D. Medical Physics III Spring 2010. Dose Computation Algorithms. Correction-based (Ancient!) Convolution (Pinnacle,Eclipse,…) Monte Carlo (Stochastic) Deterministic (Non-stochastic). Photon Source. Standard SSD. Patient...

TY - JOUR. T1 - Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. AU - Khor, Li Yan. AU - DeSilvio, Michelle. AU - Li, Rile. AU - McDonnell, Timothy J.. AU - Hammond, M. Elizabeth H. AU - Sause, William T.. AU - Pilepich, Miljenko V.. AU - Okunieff, Paul. AU - Sandler, Howard M.. AU - Pollack, Alan. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Purpose: Bcl-2 and bax are proteins with opposing roles in apoptosis regulation; yet abnormal expression of either has been associated with failure after radiotherapy (RT). In this study we examined bcl-2 and bax expression as predictive markers in men treated with radiotherapy ± androgen deprivation on Radiation Therapy Oncology Group (RTOG) protocol 86-10. Experimental Design: Suitable archival diagnostic tissue was obtained from 119 (26%) patients for bcl-2 analysis and 104 (23%) patients for bax analysis. Cox proportional hazards multivariate analysis was used to determine ...

Thiagarajan, A., Lin, K., Lu, J.J., Tan, L.K.S., Loh, T.K.S., Goh, B.C., Lin, K., Tiong, C.E. (2006). Sequential external beam radiotherapy and high-dose-rate intracavitary brachytherapy in T1 and T2 nasopharyngeal carcinoma: An evaluation of long-term outcome. Laryngoscope 116 (6) : 938-943. ScholarBank@NUS Repository. https://doi.org/10.1097/01.MLG.0000215173.14473. ...

Three dimensional conformal radiation therapy (3DCRT) involves imaging, precise radiation dose calculation, computer optimized treatment planning, and computer controlled treatment delivery. Treatment plans for each patient are individually designed. Using our state of the art technology, we are able to merge the treatment planning CT scan with diagnostic quality images, such as MRI and PET scans, to maximize the precision of our tumor targeting. All of our linear accelerators are equipped with computer controlled beam shaping devices called multileaf collimators. These permit fast and efficient delivery of 3DCRT and IMRT [1] plans. ...

TY - JOUR. T1 - Postoperative External Beam Radiotherapy for Differentiated Thyroid Cancer. T2 - Outcomes and Morbidity With Conformal Treatment. AU - Schwartz, David L.. AU - Lobo, Mark J.. AU - Ang, K. Kian. AU - Morrison, William H.. AU - Rosenthal, David I.. AU - Ahamad, Anesa. AU - Evans, Douglas B.. AU - Clayman, Gary. AU - Sherman, Steven I.. AU - Garden, Adam S.. PY - 2009/7/15. Y1 - 2009/7/15. N2 - Purpose: To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT). Methods and Materials: This is a single-institution retrospective review of 131 consecutive patients with differentiated thyroid cancer who underwent EBRT between January 1996 and December 2005. Histologic diagnoses included 104 papillary, 21 follicular, and six mixed papillary-follicular types. American Joint Committee on Cancer stage distribution was Stage III in 2 patients, Stage IVa-IVc in 128, and not assessable in 1. Thirty-four ...

Doctors can use brachytherapy alone or in addition to external-beam radiation therapy to provide a boost of radiation to a tumor while sparing surrounding normal tissue. Brachytherapy may be able to deliver higher doses of radiation to some cancers than external-beam radiation therapy while causing less damage to normal tissue.. Several brachytherapy techniques are used in cancer treatment, based on locations of cancer, dose and period of treatment. Interstitial brachytherapy uses a radiation source placed within tumor tissue, such as within a prostate tumor. Intracavitary brachytherapy uses a source placed within a surgical cavity or a body cavity, such as the chest cavity, near a tumor. Episcleral brachytherapy, which is used to treat melanoma inside the eye, uses a source that is attached to the eye.. In interstitial brachytherapy, radioactive isotopes are sealed in tiny pellets, the size of a grain of rice. These seeds are placed in the body using delivery devices, such as needles, ...

TY - JOUR. T1 - Patient-reported intestinal toxicity from whole pelvis intensity-modulated radiotherapy: First quantification of bowel dose-volume effects. AU - Sini, C.. AU - Noris Chiorda, B.. AU - Gabriele, P.. AU - Sanguineti, G.. AU - Morlino, S.. AU - Badenchini, F.. AU - Cante, D.. AU - Carillo, V.. AU - Gaetano, M.. AU - Giandini, T.. AU - Landoni, V.. AU - Maggio, A.. AU - Perna, L.. AU - Petrucci, E.. AU - Sacco, V.. AU - Valdagni, R.. AU - Rancati, T.. AU - Fiorino, C.. AU - Cozzarini, C.. N1 - cited By 0. PY - 2017. Y1 - 2017. U2 - 10.1016/j.radonc.2017.07.005. DO - 10.1016/j.radonc.2017.07.005. M3 - Articolo. VL - 124. SP - 296. EP - 301. JO - Radiotherapy and Oncology. JF - Radiotherapy and Oncology. SN - 0167-8140. IS - 2. ER - ...

The Radiation Therapy Oncology Group (RTOG) has successfully performed two multi-institutional prospective phase II trials. In RTOG 9610 trial [19], 86 patients were recruited and radiotherapy was delivered with 1.5 Gy/fraction twice per day, concurrently with hydroxyurea/5-fluorouracil (5FU) separated by 1 week of rest for 4 cycles. The late grade 3/4 toxicities were observed in 19.4% of patients. The OS was 15.2% at 2 years. There were 6 (7.6%) treatment-related deaths. The following RTOG 9911 study [20] was conducted from 2000 to 2003. It enrolled 105 patients who were treated with the identical radiation scheme (IMRT was included) but with a different concurrent chemotherapy agents (cisplatin/paclitaxel). The incidence of grade 3/4 late toxicities was high reported up to 33.8%. Eight patients (8%) of treatment-related deaths occurred. At 2 years, PFS and OS were 15.8% and 25.9%, respectively. These were relatively superior treatment outcomes (2-year OS 25.9% in RTOG 9911 vs. 15.2% in RTOG ...

Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. Dose intensification of the RTOG 85-01 regimen, examined in the Intergroup (INT)-0123/RTOG 94-05 trial, did not improve local control or survival. Areas of clinical investigation include the development of combined-modality therapy regimens with newer systemic agents, the use of 18F-fluorodeoxyglucose positron-emission tomography to assist in the development of innovative radiation treatment planning techniques, and the identification of prognostic molecular markers. The addition of surgery following primary combined-modality therapy apparently does not improve survival, but this finding is controversial.

Radiotherapy is the most commonly used treatment for nasopharyngeal cancer.. It can be used on its own to treat very early-stage cancers, or in combination with chemotherapy for more advanced cancers.. In most cases, external radiotherapy is used. It involves using a machine to focus high-energy radiation beams on to the area that requires treatment.. In nasopharyngeal cancer, an advanced form of external radiotherapy called intensity-modulated radiation therapy (IMRT) is used.. It involves aiming radiation beams of different strengths at a tumour from several different angles.. This helps maximise the dose delivered to the tumour, while minimising the effect on the surrounding healthy tissue.. Stereotactic radiotherapy is another way of giving radiotherapy externally and may be used to target a specific area where the cancer has returned.. External radiotherapy is often given in short sessions, once a day from Monday to Friday, with a break at weekends.. This is usually carried out for up to 7 ...

Read about GenesisCares external beam radiotherapy, targeting tumours from outside of the body with the latest in linear accelerator technology.

RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Current data suggest that the clinical outcomes of patients treated with external beam radiotherapy (EBRT) and those of patients treated with permanent prostate brachytherapy are comparable if properl... more

Polls show that the public do not recognise radiotherapy as a modern form of cancer therapy, and many would describe it as frightening. Yet radiotherapy is one of the most effective cancer treatments available, and a staggering array of new developments should allow radiotherapy to become increasingly personalised to individual cancer patients.. Major advances, such as Intensity Modulated Radiotherapy (IMRT), proton therapy, Cyberknife technology and research combining radiotherapy with MRI imaging, viral therapy, and chemotherapy, promise to revolutionise radiotherapy in the future.. Leading experts in radiotherapy came to the SMC discuss things such as:. ...

The purpose of the study is to evaluate the effect of simvastatin in combination with radiotherapy on the clinical outcomes of patients with brain metastases.

In addition to improving overall five-year survival of average-risk patients to 85 percent, this group had an 83 percent rate of event-free survival and a rate of five-year, event-free survival of 70 percent for high-risk patients. Event-free survival means that a child did not have medical complications or relapse that required further treatment. Moreover, the improved treatment achieved a survival rate of 66 percent as compared to 30-40 percent among children whose cancer had spread.. The results of the current clinical trial, SJMB96, are especially significant because they represent a dramatic change from the 45 percent survival rate achieved two decades ago using just surgery and irradiation, according to Gajjar. The subsequent addition of chemotherapy before or after radiotherapy improved that survival rate to 65 percent for children aged 3 years or older who had medulloblastoma.. We attribute our very promising results to the early use of high-dose radiotherapy after surgery - rather than ...

Patients with advanced cancer and short expected survival time may benefit from both symptom-relief and prevention by radiation therapy. In some cases, radiation treatment may also extend survival. Normal tissue has a greater ability to repair itself between fractionations compared to tumor tissue. Radiation therapy is therefore given with one or few fractions with good effect and little side effects. In this way, a high total dose is given to the tumor tissue but injury to healthy tissue is still limited. It is very important that acute side effects are minor and of short duration.. Palliative radiation therapy is used both for primary tumors, local recurrence, and metastases. ...

Background: Conventional radiotherapy for painful spinal metastases can be delivered with a single posterior-anterior (PA) or two opposed anterior-posterior (APPA) fields. We studied the effectiveness and toxicity of both techniques and studied whether treatment technique was predictive for abdominal and skin toxicity. Patients and methods: Within the Dutch Bone Metastasis ... read more Study, 343 patients received 8 Gray in a single fraction or 24 Gray in six fractions for painful spinal metastases. Treatment technique was not randomized. At baseline and weekly during follow-up, patients reported pain and other physical complaints. Any complaint increasing within 4 weeks after treatment was noted as a side effect. Pain response was calculated according to international standards, taking into account changes in pain score and medication. Repeated measurement analyses and multivariate logistic analyses were performed. Results: Patients were mainly treated on the thoracic (34%) and lumbar (53%) ...

I had some hormone tablets to shrink the tumor, along with a hormone shot of Luprin. I felt like I had been kicked in the groin for a day, and then began to get hot flashes. They are big, but managable--now I can relate to the ladies far better! Then 6 weeks of radiation. I went religiously, five days per week. The side effects were minimal, with a slight bit of hair loss in the groin area, and no other external results. I needed to alter my diet to foods that firmed up my stool. It was tricky to get the right balance of foods to loosen vs. foods to firm up, but after a week or so I was in a good routine. After radiation was done, I needed to slowly transfer to a more normal and then a loosening diet. After 3 weeks of being off radiation, I now have normal food, including all the hotsause I want, but I have to take 4 prunes and about 2 ounces of bran spaced throughout the day. This keeps me loose. I had some internal anal hemroids which were pretty painful, which necessitated the loose stool. I ...

The focus for this Radiotherapy Dose IOD (RT Dose IOD) is to address the requirements for transfer of dose distributions calculated by radiotherapy treatment planning systems. These distributions may be represented as 2D or 3D grids, as isodose curves, or as named or unnamed dose points scattered throughout the volume. This IOD may also contain dose-volume histogram data, single or multi-frame overlays and application-defined lookup tables. This IOD does not provide for definition of doses in beam or other coordinate systems. The application is responsible for transforming data in other, Non-Patient-Based Coordinate Systems to the Patient-Based Coordinate System described in Section C.7.6.2.1.1.. ...

External beam radiation. External beam therapy is delivered externally from a machine directed to the cancer inside the patient. Examples of external beam therapy include intensity-modulated radiation therapy and proton beam radiation. The type of machine used will be determined by the radiation oncologist. External beam therapy delivers ionizing radiation to the cancer, destroying cancer cells. ...

Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...

Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...

A detailed analysis of developments observed in products and technologies over the review period, development status of key counties operating in the international Radiotherapy Equipments market, development status of key regions in Radiotherapy Equipments market, and a comparison of international and China Radiotherapy Equipments market are also included.. Download Sample Copy@ https://www.researchnreports.com/request_sample.php?id=130791. The report is characterized into numerous parts dealing with diverse aspects of the Radiotherapy Equipments market. This research report inspects the present situation and development prognosis of the Radiotherapy Equipments market around the globe during the forecasting horizon. To determine the market size, the report analyzes revenue produced in the Radiotherapy Equipments market worldwide alongside demonstrating the segmentation of the prime producers.. Ask Your Query/Enquiry for this ...

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ed area around the radiation sources. Exposure to radiation of healthy tissues further away from the sources is therefore reduced. In addition, if the patient moves or if there is any movement of the tumour within the body during treatment, the radiation sources retain their correct position in relation to the tumour. These characteristics of brachytherapy provide advantages over EBRT - the tumour can be treated with very high doses of localised radiation, whilst reducing the probability of unnecessary damage to surrounding healthy tissues.[1]:Ch. 1[2] A course of brachytherapy can be completed in less time than other radiotherapy techniques. This can help reduce the chance of surviving cancer cells dividing and growing in the intervals between each radiotherapy dose.[2] Patients typically have to make fewer visits to the radiotherapy clinic compared with EBRT, and the treatment is often performed on an outpatient basis. This makes treatment accessible and convenient for many patients.[3][4] ...

Brachytherapy may have minor or severe side effects. Two of the most common side effects are fatigue, and irritation in the area where the catheters are inserted. Most acute side effects subside after treatment ends.

Because tumor bed contouring can be subjective, only one radiation oncologist drew the surgical clip, postoperative breast tissue change and seroma, according to the contouring guidelines [13,14]. Thus, we tried to minimize interobserver difference in our study. We measured the tumor bed cavity using a surgical clip, as well as the postoperative changes and seroma coordinates and obtained a 3-dimensional tumor bed cavity by adding a consistent margin of 1 cm around all the coordinates. There was no lesion over the surface of skin, while some lesion invading of chest wall. All of these cases, tumor bed cavities were included in tangential portal. The process was the same for the CT2. The CT planning and volumetric calculations were performed using Eclipse (ver. 7.3.10; Varian Medical Systems, Palo Alto, CA, USA). All patients were treated through the opposite tangential portal with 50.4 Gy in 28 fractions using 6 to 15 MV photons, followed by a boost dose of 9 Gy to the tumor bed, achieving a ...

Radiotherapy is used to treat conditions such as cancer, thyroid disorders and some blood disorders. It is used to treat about 40% of people with cancer. The length of each course of radiotherapy depends on the size of the cancer and where it is on the body.. During radiotherapy, controlled doses of high-energy radiation, usually X-rays, destroy cancer cells in the affected area.. Uses of radiotherapy. Radiotherapy is used for a number of different medical purposes including:. ...

Cartmill B, Cornwell P, Ward E, Davidson W, Nund R, Bettington C, Rahbari RM, Poulsen M, Porceddu S. Head Neck. 2012 Jun 23. doi: 10.1002/hed.23040. [Epub ahead of print] Abstract BACKGROUND: Research has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary.…

The long-term results of the RT01 trial, which looked at whether standard or higher doses of radiotherapy were best for treating localised and locally-advanced prostate cancer, were published in the Lancet Oncology on 26 February 2014.. The trial compared a 7.5 week course of radiotherapy (giving 74 Gy of radiation in total) with a 6.5 week course of radiotherapy (giving 64 Gy of radiation). The results show that, 10 years after treatment, men who had the higher dose of radiotherapy were less likely to have signs of their cancer coming back or getting worse. 55 per cent of men in the higher dose group had no signs of their disease getting worse, compared to 43 per cent who had the standard dose.. Men who received the higher dose were also less likely to need to start treatment with long-term hormone therapy within 10 years.. However, the trial found that there was no difference in how long men treated with the higher or standard doses lived. Men in both groups of the trial lived much longer than ...

The results of our study have shown that SIB-IMRT reduced the toxicity without compromising the outcome in patients with localized prostate cancer treated to 78 Gy radiation.

xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. Experimental studies with normobaric carbogen and oxygen showed a two-fold enhancement of the efficacy of radiation in a mouse tumour model when combining oxygen with treatment acceleration. It was then demonstrated that substituting carbogen for oxygen and adding high-dose nicotinamide (NAM) further increased the effect. These findings became the basis for a multi-factorial approach designed to overcome the radioprotective effect of tumour repopulation and that of perfusion-limited and diffusion-limited hypoxia. The strategy, named ARCON, combines Accelerated Radiotherapy with CarbOgen and Nicotinamide.. Experimental evaluation of ARCON. The therapeutic potential of carbogen combined with NAM (CON) focusing on ...

When the testes contain some leukaemia cells, radiation treatment (radiotherapy) to the testes is recommended. The total radiation dose has to be spread out over quite a long time to make the individual treatments safe. We usually give 12 treatments, one every day (usually excluding weekends and bank holidays). At each session, the patient spends about ten minutes in the treatment room but most of this time is spent getting him/her into exactly the right position.. Radiotherapy does not hurt; it is rather like having an ordinary X-ray. So that we can treat both testes the patient must lie very still on their back. Lying still can be very difficult for some children, especially very young ones. Occasionally we have to use a general anaesthetic.. ...