The benefit of adjuvant radiotherapy (ART) for extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma (GBC) is unclear, with conflicting results from nonrandomized studies. We reported a meta-analysis to determine the impact of adjuvant radiotherapy on survival. PubMed, EMBASE, Cochrane Library and CNKI databases were searched to identify clinical trials of postoperative ART versus no radiotherapy for EHCC and GBC. The obtained data were analyzed using RevMan 5.3 and Stata 14.0 statistical software. Differences between two groups were estimated by calculating the odds ratio (OR) and 95% confidence interval (CI). A total of 21 clinical trials involving 1465 EHCC and GBC patients were selected according to the inclusion and exclusion criteria and included in this meta-analysis. The meta-analysis showed the following: The 5-year overall survival (OS) rate was higher in the ART group than in the no radiotherapy group (OR = 0.63; 95% CI = 0.50-0.81, p = 0.0002). The 5-year OS rate was significantly
MONDAY, Aug. 12, 2019 (HealthDay News) - Adjuvant radiotherapy after radical prostatectomy compared with surgery alone may prolong biochemical recurrence-free survival in patients with locally advanced prostate cancer, according to a study published online July 29 in European Urology.. Greetta Hackman, of the University of Helsinki, and colleagues recruited a total of 250 patients at eight hospitals in Finland who had either pT2 prostate cancer with positive margins or pT3a, pN0, M0 cancer regardless of margins. Patients were randomly assigned to an adjuvant radiotherapy or observation group. The adjuvant radiotherapy group received a radiation dose of 66.6 Gy. The median follow-up time was 9.3 years for patients in the adjuvant radiotherapy group and 8.6 years for patients in the observation group.. The researchers found that the group receiving adjuvant radiotherapy had a higher 10-year recurrence-free survival rate than the observation group (82 versus 61 percent; hazard ratio, 0.26; 95 ...
Whats more, a separate, but related study, found that urologists were less likely than radiation oncologists to recommend adjuvant radiation therapy or to believe it improves overall survival.. There has been question over whether administering adjuvant radiation therapy after removing the prostate is an appropriate course of action because of associated toxicities, risk of overtreatment and costs, even with data supporting its benefits to overall survival, but a new decision analysis published online in the Annals of Oncology on June 9 found that the procedure is a practical option for patients.. "This work demonstrates that adjuvant radiation therapy is a cost-effective strategy for selected patients after prostatectomy," said Laura Pizzi, PharmD, Associate Professor at the Jefferson School of Pharmacy, and senior author of the study. "It is typical for cancer treatments to provide clinical benefit at a cost; however, the cost per success that we reported for adjuvant radiation therapy is on ...
Recent studies on the impact of adjuvant radiotherapy on local control, survival and quality of life in patients with breast cancer have been evaluated. Following these studies, breast conserving surgery with subsequent radiation therapy is the stand
Cost-effectiveness of adjuvant radiotherapy in intermediate risk endometrial cancer.s profile, publications, research topics, and co-authors
Selected high-risk patients with head and neck squamous cell carcinoma receive postoperative radiation therapy (RT), with or without concurrent chemotherapy, following primary surgical resection with the aim of improving locoregional control and surv
Adjuvant radiation therapy administered early after radical prostatectomy is more effective than observation, at a mean additional cost of $6,023, resulting in a 10-year incremental cost-effectiveness ratio of $26,983, according to a study published June 9 in the Annals of Oncology.
Surgery and radiation are often used together in more advanced lesions. As combined treatment has evolved, surgery with postoperative radiation therapy is most often employed. Recent advances in reconstructive surgery have further improved functional and cosmetic outcomes.. In select instances, promising results are being obtained with combined chemotherapy and radiation therapy in an effort to avoid surgical resection.. ...
TY - JOUR. T1 - Trends in the application of postmastectomy radiotherapy for breast cancer with 1 to 3 positive axillary nodes and tumors ≤5 cm in the modern treatment era. T2 - A retrospective Korean breast cancer society report. AU - Chang, Jee Suk. AU - Choi, Jung Eun. AU - Park, Min Ho. AU - Jung, Sung Hoo. AU - Choi, Byung Ock. AU - Park, Hyung Seok. AU - Park, Seho. AU - Kim, Yong Bae. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Despite high-level evidence, the benefit of postmastectomy RT in these patients in recent years has not been fully elucidated. We investigated postmastectomy radiotherapy (RT) use and evaluated clinicopathologic and treatment factors influencing RT use in Korean women with pT1-2N1 breast cancer. We identified women diagnosed with pT1-2N1 breast cancer between 1994 and 2009 using the Korean Breast Cancer Registry. Factors associated with RT use were evaluated using logistic regression analysis. The median follow-up was 95 months. Of the 6196 women, 11.9% underwent ...
The delivery of cancer treatment following local treatment with surgery is referred to as "adjuvant" therapy and may include chemotherapy, radiation therapy, hormonal therapy and/or biologic therapy. The goal of adjuvant radiation therapy is to eradicate any remaining cancer cells after surgery. Adjuvant radiation therapy may consist of brachytherapy and/or external beam radiation.. Stage I Uterine Cancer: Although it is still being evaluated in clinical trials, many patients with stage IB and IC uterine cancer are often treated with adjuvant radiation therapy. When the uterus is surgically removed, the cut ends of the vagina are surgically sewn together forming a "vaginal cuff". The vaginal cuff is a common site of local cancer recurrence following treatment with surgery alone. Women with stage I uterine cancer who receive treatment with surgery and postoperative radiation therapy have a 5-year survival of 80-90% and a local cancer recurrence rate of only 4-8%.. A large clinical trial that ...
The American Society for Radiation Oncology (ASTRO) has issued a new guideline, "The Role of Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based Guideline," that details the use of adjuvant radiation therapy in the treatment of endometrial cancer. The guidelines executive summary is published in the May-June 2014 issue of Practical Radiation Oncology.. ASTROs Guidelines Panel of 17 leading gynecologic specialists compiled and reviewed extensive data from 330 studies from MEDLINE, EMBASE and the Specialized Register of the Cochrane Gynaecological Cancer Review Group published from 1980 to 2011. The data population selected for the guideline was defined as women of all races, age 18 or older, with stage I to IV endometrial cancer of any histologic type or grade. The studies included patients who underwent a hysterectomy followed by no adjuvant therapy, or pelvic and/or vaginal brachytherapy with or without systemic chemotherapy.. The panel identified five key ...
Purpose: The optimal number of axillary nodes to be resected is controversial. This large series investigated the effect of surgery with or without adjuvant radiotherapy among node-negative breast cancer patients in relation to the number of nodes examined. Methods and materials: Node-negative patients from the Saskatchewan registry of 1981-1995 were studied. Because nodal status may be more reliable with more number of nodes examined, we analyzed T1-2 age | 90 patients with | 10 nodes examined treated with surgery alone (Group A_S, n = 509) vs. surgery and adjuvant radiotherapy (Group A_S+R, n = 342); and T1-2 age | 90 patients with | or = 10 nodes examined treated with surgery alone (Group B_S, n = 902) vs. surgery and adjuvant radiotherapy (Group B_S+R, n = 596). Results: For the two radiotherapy groups, patients with | 10 nodes (Group A_S+R) vs. | or = 10 nodes (Group B_S+R), there was no difference in overall survival (p = 0.14). In the two nonradiotherapy groups (A_S and B_S), there is a
To determine the long-term outcome of a consistent treatment approach with electron beam postmastectomy radiation therapy (PMRT) in breast cancer patients with , or =10 positive nodes treated with combined-modality therapy.TSixty-three breast cancer patients with , or =10 positive lymph nodes were treated with combined-modality therapy using an electron beam en face technique for PMRT at the University of Florida. Patterns of recurrence were studied for correlation with radiation fields. Potential clinical and treatment variables were tested for possible association with local-regional control (LRC), disease-free survival (DFS), and overall survival (OS).TAt 5, 10, and 15 years, OS rates were 57%, 36%, and 27%, respectively; DFS rates were 46%, 37%, and 34%; and LRC rates were 87%, 87%, and 87%. No clinical or treatment variables were associated with OS or DFS. The use of supplemental axillary radiation (SART) (p = 0.012) and pathologic N stage (p = 0.053) were associated with improved LRC. ...
To determine the safety and feasibility of combining post-operative radiation therapy, and hormonal therapy (6 months) and concurrent docetaxel in men with high risk pathologic T2-3N0 prostate cancer after a radical prostatectomy.. To obtain preliminary information regarding the efficacy of combining weekly docetaxel with adjuvant radiation therapy and hormonal therapy in men with high risk pathologic T2-3N0 prostate cancer by determining PSA failure free survival.. To assess baseline and longitudinal changes in health-related quality of life outcomes during and after therapy (at 3, 6, 12 and 24 months) ...
OUTLINE: This is a randomized, open-label study. Patients are randomized to 1 of 2 treatment arms.. All patients undergo apheresis for the collection of peripheral blood monocytes that are cultured with interleukin-4 and sargramostim (GM-CSF) to produce dendritic cells. The dendritic cells are infected with a recombinant adenoviral vector containing the wild-type p53 gene.. Patients receive doxorubicin IV and cyclophosphamide IV every 2 weeks for 8 weeks (4 courses) followed 2 weeks later by paclitaxel IV every 2 weeks for 8 weeks (4 courses). Patients with stage III disease then undergo surgery. Three weeks after completion of paclitaxel (or after surgery for patients with stage III disease), patients undergo radiotherapy once daily for 6.5 weeks. Patients are then receive vaccine therapy as per the arm to which they were randomized.. ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
In this manuscript, we show that treatment with low doses of fractionated radiotherapy leads to upregulation of PD-L1 expression on tumor cells secondary to CD8+ T-cell production of IFNγ. In models of melanoma, colorectal, and breast cancer, we demonstrate that the efficacy of radiotherapy can be enhanced through combination with αPD-L1 mAb, leading to the generation of memory immunity in LTS mice capable of protecting against tumor recurrence. Furthermore, our data reveal that dose scheduling may be critical for outcome with concurrent but not sequential therapy effective at improving local tumor control and survival.. Recent clinical trials have begun to evaluate blockade of the PD-1/PD-L1 axis with encouraging responses observed in multiple disease settings with mAb targeted against both PD-1 and PD-L1 (18-20, 24, 25). Despite this, combination approaches may be required to improve response rates and to generate durable antitumor immunity. We and others have demonstrated the potential to ...
Kubicek, Gregory J; Krishnan, Leela; Kimler, Bruce F; Al-kasspooles, Mazin; Reddy, Eashwer K; Wang, Fen; Jewell, William R (2008-11-24) ...
The function of postoperative radiotherapy (PORT) in patients with completely resected pathologically N2 (pN2) non-small cell lung cancer (NSCLC) remains controversial due to a lack of prospective studies. The present study aimed to evaluate the efficacy of PORT in completely resected pN2 NSCLC when using modern radiation techniques, and to determine the associations between clinicopathological factors and PORT and survival rates. Following patient selection, 246 out of 269 consecutive patients with pN2 NSCLC were enrolled in the present study, with 88 patients having received postoperative chemotherapy (POCT) and PORT, 90 having received adjuvant chemotherapy, 1 having received adjuvant radiotherapy and the remaining 67 having received no adjuvant therapy ...
Radiotherapy has been considered a local modality and outcomes have emphasized local and regional control of tumors. Recent data suggests that radiotherapy may activate the immune system and the combination of radiation therapy and immune therapies may have the potential to improve both local and distant control of tumor deposits. Below we review principals underlying the concepts of combining both modalities.
This phase II trial is comparing adjuvant radiotherapy with delayed radiotherapy in people who have previously resected cancer that has spread to the brain
Primary Endpoint: To determine the maximum tolerated dose (MTD) of vorinostat + radiation therapy (RT) in patients with locally advanced pancreat
2016 Annual Meeting: Breast Reconstruction Trends in the Setting of Postmastectomy Radiotherapy: An Evaluation of the National Cancer Data Base from 2004-2013
PSRC 2017 Abstracts: Implant-Based Breast Reconstruction and the Timing of Adjuvant Radiotherapy: A Systematic Review and Meta-Analysis of Surgical Outcomes
The initial literature search identified 7,453 studies. We excluded 1,931 duplicates and excluded 5,504 studies by title screening because they did not meet the eligibility criteria. Eighteen randomized controlled trials were selected for full-text review, and 15 papers were discarded; 6 trials compared surgery alone and surgery plus postoperative radiation, 2 compared surgery alone and preoperative longcourse radiation plus surgery, 6 compared surgery alone and preoperative short-course radiation and surgery, and one was long-term results of a previous reported trial. Three randomized trials comparing preoperative CRT with postoperative CRT in resectable stage II-III rectal cancer were finally identified; Park et al. [9] in 2011, Roh et al. [10] in 2009, and Sauer et al. [5] in 2004 (Fig. 1). All patients in both preoperative and postoperative arms received conventionally fractionated radiotherapy of 50-54 Gy with 1.8-2 Gy per fraction for 5-6 weeks. Concurrent chemotherapy of intravenous ...
For localized MCC (stage I: n = 3369, stage II: n = 1474 ), surgery plus adjuvant RT was associated with statistically significantly better OS than with surgery alone in multivariable analyses (stage I: hazard ratio [HR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.80, P , .001; stage II: HR = 0.77, 95% CI = 0.66 to 0.89, P , .001). In patients with regional nodal metastases (stage III: n = 2065 ), neither adjuvant RT nor chemotherapy was associated with statistically significantly improved or worsened OS.. ...
Health, ...Accelerated whole breast irradiation after lumpectomy is an effective ...,Accelerated,radiation,treatment,effective,for,noninvasive,breast,cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The major goal of radiation treatment is to kill meningioma tumor cells while minimizing damage to surrounding normal brain tissue. Radiation therapy for meningiomas involves externally beaming from a machine high energy X-rays at the tumor site (known as external beam radiation). There are variations of radiation therapy and the type chosen is based on factors used for determining treatment options discussed at the beginning of this section (size, location, symptoms, age and health of patient), as well as the extent of tumor removal and the WHO grade of the meningioma.. Radiation therapy is often prescribed following surgery where there has been incomplete tumor removal, regardless of the tumor grade. When used as such, the treatment is called adjuvant radiotherapy, meaning it is used in addition to the primary treatment option of surgery in order to increase the chances of a more positive outcome. In the case of benign meningiomas that were incompletely removed, its use has been effective in ...
... is used to treat conditions such as cancer, thyroid disorders and some blood disorders. It is used to treat about 40% of people with cancer. The length of each course of radiotherapy depends on the size of the cancer and where it is on the body.. During radiotherapy, controlled doses of high-energy radiation, usually X-rays, destroy cancer cells in the affected area.. Uses of radiotherapy. Radiotherapy is used for a number of different medical purposes including:. ...
Breast-conserving surgery for breast cancer has been developed to accomplish two major goals: the achievement of tumor-free resection margins and prevention of…
Radiotherapy to the breast can sometimes lead to long-term side effects. A few months after radiotherapy some women develop breathlessness (due to the effect of radiotherapy on the lung). This can usually be treated with a short course of steroids. In the longer term there may be some weakness of the ribs in the irradiated area, which makes them more likely to fracture than normal. If you have radiotherapy to your underarm (axilla) there is a very small risk of developing late side effects such as nerve pain, tingling, and weakness or numbness in the arm and hand (peripheral neuropathy ...
Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Ho on chemo savvy: Definitely you should get an adjuvant radiation therapy following mastectomy. As per- chemo- if you get chemo first before surgery and unfortunately the response is only marginal- that indicates that your cancer is likely is resistant to chemo.So, adding more chemo post mastetcomy doubtfully will give you any benefit. Is this er+ or er-? If this is er+- then you should get aromatase inhibitor.
Introducing standardized data collection (SDC) for lung cancer patients to improve the performance of the prediction models.
PORTEC-2: Postoperative Radiation Therapy for Endometrial Carcinoma a multicenter randomised phase III trial comparing external beam radiation and vaginal brachytherapy Study coordinator: C.L. Creutzberg
49yr old man with pT4 Sq cell cancer, post adjuvant chemotherapy for local RT detected to have cerebellar lesion , radically treated, ? role of adjuvant RT to the primary tumour bed ...
Scientists reveal that targeting a pathway in cancer cells that controls the motion of their mitochondria could make them more yielding to radiotherapy.
The grim reality, based on research that 38.5% of all people, men and women, will be diagnosed with cancer at some point during their lifetime.
According to the results from international studies, chemotherapy and radiotherapy exposure in the womb did not affect babies mental and cardiac development.
automatic roll changer: Ferris-wheel type device (usually) which stores 2 to 12 perforated paper rolls and changes them automatically, usually in the sequence in which they are placed on the changer mechanism (or, if desired, a particular roll can be selected). Several variations occur, including a device made by Philipps which incorporates extra roll-holding sections which hang below the basic revolver mechanism; and a 10-roll cartridge-type changer unit, called a 10-roll magazine, by Popper & Co., but constructed on different principles from those used in a standard revolver- or magazine-type mechanism. Perhaps the most sophisticated roll changing device was one developed by Hupfeld, which, in its most elegant form, consisted of two 10-roll changers arranged side by side (for a total selection of 20 rolls) and equipped with a device for selecting a desired roll from a distant control panel or wallbox. In America, the Wurlitzer Automatic Roll Changer (capitalized in Wurlitzers usage) achieved ...
In the current study, the presence of a breast implant during postmastectomy radiotherapy was not associated with increased doses to ipsilateral lung and heart.. Koutcher et al. were the first to analyze radiotherapy plans in 41 patients with expandable implants. They reported excellent local control and acceptable heart and lung doses; 73% patients had adequate chest wall coverage, lung V20Gy in the majority of patients was ,20% and mean heart dose was 2.8 Gy. This study, however, is limited by the small sample size and the absence of a control group of patients without breast reconstruction [13].. In another publication, radiation plans of a mixed patient population with autologous tissue reconstruction from the abdomen (n = 107) and autologous tissue reconstruction from the back +/- implants (n = 5) were compared with selected controls without IBR (n = 106) matched by calendar year, side and tumor stage. Using a novel non-validated scoring system, the authors concluded that more than half of ...
Non-Invasive Brachytherapy Treatment Supplements Breast Conservation Therapy. BUFORD, Ga.--(BUSINESS WIRE)--Theragenics Corporation®, a medical device company serving the cancer treatment and surgical product markets, has reached an agreement with Advanced Radiation Therapy, LLC to distribute the AccuBoost® technology for the treatment of early stage breast cancer. The AccuBoost technology, developed by Advanced Radiation Therapy of Tyngsboro, MA, is used to provide a radiation "boost" following a lumpectomy. A radiation boost to the lumpectomy cavity margin as part of breast conservation therapy is the standard of care to minimize cancer recurrence. AccuBoost is also used as a non-invasive option for accelerated partial breast irradiation (APBI), a form of primary radiation therapy following lumpectomy. Under the agreement Theragenics is the exclusive third-party distributor of AccuBoost in the United States. AccuBoost, a real time mammography-guided radiation therapy, has been used to treat ...
Purpose: The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus postoperative external beam radiation therapy...
Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p ≤ 0.05). In Cox-2-negative cases of ...
The aim of this study was to compare outcomes of postoperative whole brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) alone in patients with resected brain metastases (BM). We reviewe
Introduction: Fatigue is the most troublesome untreated symptom during radical breast radiotherapy. This situation persists due to an uncertain aetiology and an inability to identify patients at high risk of experiencing significant fatigue during subsequent radiotherapy. Aetiological investigations of the current study concentrated on discriminating the radiotherapy-specific effects on fatigue, in a context encompassing multiple psychological and physiological covariates. Prognostic aspects sought to characterise a high-risk patient. Methods: The study cohort comprised 100 women, diagnosed with Stage 0 to IIA breast cancer, and prescribed standard whole breast irradiation to 40Gy in 15 fractions over three weeks. The use of systemic therapies was an exclusion criterion. A cytokine-induced sickness behaviour model framed the study investigations, and provided a theoretical link between localised radiotherapy and systemic fatigue. The outcome fatigue was assessed before, during and four weeks ...
Evaluation and management of lymph node metastasis should be performed in all patients with MCC, because lymph node metastasis develops in up to 75% of patients
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True or False. A positive margin which is defined as ink on ductal carcinoma in situ (DCIS) is associated with an increase in ipsilateral breast tumor recurrence (IBTR), which is nullified by the use of whole-breast radiation therapy (WBRT). ...
Colon cancer is a major public health problem. The primary treatment is resection. For patients with early-stage disease, surgery results in excellent survival rates. In contrast, patients with locally advanced tumors arising in anatomically immobile segments of large bowel have a less satisfactory outcome, in part secondary to compromised surgical clearance. Patterns-of-failure analyses suggest that for tumors that invade adjacent organs, exhibit perforation or fistula, or are subtotally resected, local failure rates exceed 30%. Multiple single-institution retrospective studies have shown improved local control and possibly survival with the addition of external irradiation and/or intraoperative radiation. In contrast, a recent Intergroup trial failed to show any benefit by the addition of adjuvant radiation therapy combined with chemotherapy. Interpretation of this trials results is handicapped by low patient accrual. With the advent of novel and more effective systemic therapies for metastatic