Contents: The Fundamentals.- The History of Stereotactic Radiosurgery.- Neuroimaging in Radiosurgery Treatment Planning and Follow-up Evaluation.- Techniques of Stereotactic Radiosurgery.- Radiation Biology and Physics.- The Physics of Stereotactic Radiosurgery.- Radiobiological Principles Underlying Stereotactic Radiation Therapy.- Experimental Radiosurgery Models.- Treatment Planning for Stereotactic Radiosurgery.- Designing, Building and Installing a Stereotactic Radiosurgery Unit.- Stereotactic Radiosurgery Techniques.- Gamma Knife Radiosurgery.- Linear Accelerator Radiosurgery.- Proton Beam Radiosurgery: Physical Bases and Clinical Experience.- Robotics and Radiosurgery.- CyberKnife Radiosurgery.- Treatment of Disease Types.- Brain Metastases.- Metastatic Brain Tumors: Surgery Perspective.- Brain Metastases: Whole-Brain Radiation Therapy Perspective.- High-Grade Gliomas.- Malignant Glioma: Chemotherapy Perspective.- Meningioma.- Meningioma: Surgery Perspective.- Intracranial Meningioma: ...
This study compares administration schedules of experimental MPDL3280A (antibody- a protein produced by the bodys immune system) and stereotactic ablative radiotherapy in treating patients with lung cancer. MPDL3280A, may block tumor growth in different ways by targeting certain cells. Stereotactic ablative radiotherapy, is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Giving MPDL3280A with stereotactic ablative radiotherapy may be a better treatment for lung cancer. However, it is not yet known what the best administration schedule is for these treatments. ...
TY - JOUR. T1 - CyberKnife radiosurgery in four cases of choroidal malignant melanoma. AU - Tabira, Emi. AU - Yoshikawa, Hiroshi. AU - Kawano, Yoh Ichi. AU - Ueno, Ichiro. AU - Kohno, Ri Ichiro. AU - Hasegawa, Yuhei. AU - Ishibashi, Tatsuro. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Purpose : To report four cases who received CyberKnife radiosurgery for choroidal malignant melanoma. Cases : CyberKnife radiosurgery was performed on 4 cases of choroidal malignant melanoma. The series comprised 3 males and one female. The age ranged from 57 to 82 years. The height of the tumor ranged from 2.8 to 6.7 mm, average 5.3 mm. Each eye received a case 10 Gy of radiation per session totaling 50 Gy after 5 sessions. The tumor showed a decrease in size. The height ranged 0.2 to 5.2 mm, average 3.9 mm after 6 to 36 months of treatment. One eye developed vitreous hemorrhage. Otherwise, there was no local recurrence or rubeotic glaucoma. Conclufion : CyberKnife radiosurgery was effective in four cases of choroidal ...
TY - JOUR. T1 - Imaging characteristics of local recurrences after stereotactic body radiation therapy for stage I non-small cell lung cancer. T2 - Evaluation of mass-like fibrosis. AU - Hayashi, Shinya. AU - Tanaka, Hidekazu. AU - Hoshi, Hiroaki. PY - 2015/3/1. Y1 - 2015/3/1. N2 - Background: This study aimed to evaluate stereotactic body radiation therapy (SBRT) in patients with stage I non-small cell lung cancer (NSCLC) in terms of radiation-induced changes and computed tomography (CT) features of local recurrence by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). Methods: From January 2006 to December 2012, 81 patients with NSCLC received SBRT. Follow-up consisted of non-contrast enhanced CT scans performed before and every four months after SBRT. In addition, 18F-FDG-PET/CT was conducted before SBRT for each patient, and one year later for each case suspected of recurrence. The CT findings were classified into two categories: mass-like fibrosis and others. The mass-like ...
The researchers found that there was less cognitive deterioration at 3 months after stereotactic radiosurgery alone (40/63 patients, 64%) than when combined with whole brain radiotherapy (44/48 patients, 92%). Quality of life was higher at three months with stereotactic radiosurgery alone, including overall quality of life. There was no significant difference in functional independence at three months between the treatment groups. Median overall survival was 10.4 months for stereotactic radiosurgery alone and 7.4 months for stereotactic radiosurgery plus whole brain radiotherapy. For long-term survivors, the incidence of cognitive deterioration was less after stereotactic radiosurgery alone at three months and at 12 months.. "In the absence of a difference in overall survival, these findings suggest that for patients with one to three brain metastases amenable to radiosurgery, stereotactic radiosurgery alone may be a preferred strategy," the authors write.. "The debate between whole brain ...
Research by Beaumont Health System radiation oncologists and neurosurgeons found that symptoms of trigeminal neuralgia, or TN, a nerve disorder causing severe facial pain, were reduced in those treated with Gamma Knife stereotactic radiosurgery. The results were published recently in the journal Clinical Neurology and Neurosurgery.
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Effect of Ape1/Ref-1 on injury caused by stereotactic ablative radiotherapy in the treatment of early stage non-small cell lung cancer, Lei Han, Renzhi Yu, Xin Ni, Zenglei Zhang
Objective: To explore the effect of Ape1/Ref-1 on injury caused by stereotactic ablative radiotherapy in the treatment of early stage non-small cell l..
Nieder, Carsten; Andratschke, Nicolaus H; Guckenberger, Matthias (2015). A pooled analysis of stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small cell lung cancer: is failure to recruit patients into randomized trials also an answer to the research question? Annals of Translational Medicine, 3(11):148-151. ...
The purpose of this study was to compare patterns of failure between lobar resection (lobectomy or pneumonectomy) and stereotactic body radiation therapy (SBRT) for patients with clinical stage I non-small-cell lung cancer (NSCLC). From January
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TY - JOUR. T1 - Stereotactic body radiation therapy of liver tumors. T2 - post-treatment appearances and evaluation of treatment response: a pictorial review. AU - Haddad, Mustafa M.. AU - Merrell, Kenneth W.. AU - Hallemeier, Christopher. AU - Johnson, Geoffrey B. AU - Mounajjed, Taofic. AU - Olivier, Kenneth R.. AU - Fidler, Jeff L.. AU - Venkatesh, Sudhakar K. PY - 2016/5/11. Y1 - 2016/5/11. N2 - Stereotactic body radiation therapy (SBRT) is a noninvasive treatment technique for selected patients with primary liver tumors and liver-confined oligometastatic disease. Recently, SBRT has emerged as an alternative treatment option in non-surgical candidates and in whom percutaneous treatment methods are not possible or contraindicated. The experience with SBRT continues to grow. There are currently no imaging guidelines for assessment of tumor response and follow-up schedule following SBRT. SBRT produces characteristic radiation-induced changes in the treated tumor and surrounding liver ...
Stereotactic ablative radiotherapy (SABR) shows a remarkable local control of non-small cell lung cancer (NSCLC) metastases, partially as a result of host immune status. However, the predictors of immune cells for tumor response after SABR are unknown. To that effect, we investigated the ability of pre-SABR immune cells in peripheral blood to predict early tumor response to SABR in patients with lung metastases from NSCLC. This study included 70 patients with lung metastases from NSCLC who were undergoing SABR. We evaluated the early tumor response 1 month and 6 months after SABR in these patients following RECIST 1.1 guidelines. Pre-SABR peripheral CD8+ T cell count, CD8+CD28+ T-cell count, CD8+CD28− T-cell count, CD4+ T-cell count, and Treg-cell count were measured using flow cytometry. Increased CD8+CD28+ T-cell counts (14.43 ± 0.65 vs. 10.21 ± 0.66; P = 0.001) and CD4/Treg ratio (16.96 ± 1.76 vs. 11.91 ± 0.74; P = 0.011) were noted in 1-month responsive patients, compared with non-responsive
This study aimed to evaluate the effect of stereotactic ablative radiotherapy (SABR) after incomplete transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. The study enrolled 178 HCC patients initially treated with TACE between 2006 and 2011. Patients were included if they had Barcelona Clinic Liver Cancer stage 0 or A, ≤3 nodules with a total sum of longest diameter ≤10 cm, Child-Turcotte-Pugh score of ≤7, no major vessel invasion, and no extra-hepatic metastases. Twenty-four patients achieved a complete response to TACE (group 1). Among those with incomplete response, 47 patients received other curative treatments (group 2), 37 received SABR (group 3), and 70 received non-curative treatments (group 4). The 2-year overall survival (OS) rates for groups 1, 2, 3, and 4 were 88 %, 81 %, 73 %, and 54 %, respectively. The corresponding 5-year OS rates were 50 %, 58 %, 53 %, and 28 %, respectively. Patients treated with SABR after incomplete TACE had similar
TY - JOUR. T1 - Stereotactic radiosurgery of residual or recurrent craniopharyngioma. T2 - New treatment concept using leksell gamma knife model C with automatic positioning system. AU - Yomo, Shoji. AU - Hayashi, Motohiro. AU - Chernov, Mikhail. AU - Tamura, Noriko. AU - Izawa, Masahiro. AU - Okada, Yoshikazu. AU - Hori, Tomokatsu. AU - Iseki, Hiroshi. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Background/Aims: The present study analyzed the initial experience with the application of the original concept of robotic microradiosurgery using Leksell Gamma Knife Model C with automatic positioning system for management of craniopharyngiomas. Methods: Eighteen patients with residual or recurrent craniopharyngiomas underwent radiosurgery with the use of multiple isocenters, mainly of smaller size, which were positioned compactly within the border of the lesion with resultant improved dose homogeneity, increased average dose within the target, and sharp dose fall outside the treated volume. Treatment ...
The Japanese Ministry of Health, Labor and Welfare (MHLW) gave the latest CyberKnife Radiosurgery the Shonin approval. The CyberKnife G4 Robotic Radiosurgery Systems from Accuray Inc., will be available in Japan to treat tumors non-invasively anywhere in the body, including head and neck. This regulatory approval dramatically expanded the types of Japanese patients that could be treated with radiosurgery to include those with cancers of the spine, lung, liver, pancreas and prostate.. The CyberKnife G4 System addresses the unique challenges of random and excessive target motion by using intelligent and adaptive image guidance, which minimizes dose to surrounding healthy tissue and critical structures, ultimately minimizing treatment complications and side effects.. The CyberKnife G4 System will provide Japanese patients with some of the latest advances in CyberKnife technology including: Motion management technology to correct for tumor motion including the Xsight Lung Tracking System, which ...
SAN FRANCISCO, Oct. 15 /PRNewswire/ -- Elekta will showcase updates to its Leksell GammaPlan® 10.0* treatment planning software for Leksell Gamma Knife® and the Extend™ program for Leksell Gamma Knife® Perfexion™ at the 2010 Congress of Neurological Surgeons [1] (CNS) Annual Meeting, October 16-21 at the Moscone Convention Center in San Francisco. The Extend program [2] dramatically broadens the types of cases for which clinicians can use Perfexion.. On the show floor, Elekta booth #109 will feature hands-on demonstrations of Extend, which combines patient-friendly head immobilization technology and stereotactic localization methods to permit hypofractionated Gamma Knife treatments [3] for larger tumors or lesions close to critical structures located in the brain, skull base and other head and neck regions.. Updates to GammaPlan 10.0 [4] include the two optional add-ons Inverse Planning and Convolution. Inverse Planning provides a fast, easy solution for Gamma Knife surgery planning, ...
TY - JOUR. T1 - Stereotactic body radiation therapy. T2 - Rationale, techniques, applications, and optimization. AU - Song, Danny Y.. AU - Kavanagh, Brian D.. AU - Benedict, Stanley H. AU - Schefter, Tracey. PY - 2004/10. Y1 - 2004/10. N2 - Stereotatic body radiation therapy (SBRT) is a rapidly evolving cancer treatment method in which concepts and techniques previously developed for brain tumor radiosurgery are adapted to eradicate tumors elsewhere in the body. The spatial accuracy, conformality, and steep radiation dose gradients of radiosurgery, which have been critical to its success in the treatment of intracranial tumors, are applied in SBRT to treat a variety of extracranial tumors. Early results demonstrate excellent response rates and low toxicity with a variety of hypofractionated dose regimens and localization/immobilization techniques. This article provides an overview of the rationale and results of SBRT for specific indications, descriptions of some methods of treatment delivery, ...
The Jewish Hospital - Mercy Health offers minimally-invasive brain surgery through state-of-the-art, pinpoint-accurate radiosurgery. The Jewish Hospital features Leksell Gamma Knife® Perfexion™, an advanced radiosurgical device that uses radiation to perform precision brain surgery with no incisions. This technology is the first of its kind in Greater Cincinnati. The Jewish Hospital is one of approximately 250 hospitals worldwide to offer this life-extending treatment.. The Gamma Knife® treats brain tumors and neurological conditions without the normal risks associated with surgery and a long hospital stay. Gamma Knife® radiosurgery uses 192 beams of radiation to precisely target tumors deep within the brain without incisions. Most patients are able to go home the same day. More than 30 years of clinical studies documented in more than 2,500 published medical papers demonstrate the effectiveness of Gamma Knife® radiosurgery.. With the Gamma Knife® Perfexion™, The Jewish Hospitals ...
Doctors give unbiased, trusted information on the use of Gamma Knife Surgery for Meningioma: Dr. Bonuel on radiation necrosis after gamma knife surgery for meningioma: Stereotactic surgery is usually a minimally invasive procedure using x-ray and computers to locate a spot or lesion to perform a needle biopsy through a very small incision. Gamma knife is a non-invasive procedure to deliver very carefully a high dose of radiation therapy with specialized equipment to treat a lesion or tumor with no incision.
Novalis powered by TrueBeam STx & BrainLab ExacTrac. Female patient 60 years with 2 column injuries L1 and T12 treated each with 2 dynamic arches, 10 MV photons and 20 Gy FFF 120 MicroMLC HD in 5 sessions.. Stereotactic Body Radiation Therapy is a therapeutic modality to manage, in a few sessions and with great precision, very high doses of radiation to the tumor effectively and with minimal toxicity to surrounding healthy tissue. Side effects are few. It is a treatment technique aimed at patients with tumors or metastases are inoperable and have injuries because of its location, cant be eradicated. The SBRT is a technique minimally invasive which allows the patient to receive treatment on an outpatient basis, without it is hospitalized.. The SBR requires precise planning to the target volume or target, since it is administered from different angles. This requires the use of 4 dimensional volumetric images mode, such as computed tomography (CT), taking into account the movement. These images ...
What is the COST Of Gamma Knife Radiosurgery in India: Why is Gamma Knife Radiosurgery so affordable Price? Know about the surgery and answers to FAQs at Spine and Neuro Surgery Hospital India.
Baehring JM, Hochberg FH. Primary Nervous System Tumors in Adults. In: Dariff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradleys Neurology in Clinical Practice . 7th ed. Philadelphia, PA: Elsevier; 2016:chap 74. Brown PD, Jaeckle K, Ballman KV, et al. Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA . 2016;316(4):401-409. PMID: 27458945 www.ncbi.nlm.nih.gov/pubmed/27458945 . Elekta AB. Gamma Knife radiosurgery patient resource center. 2015. www.elekta.com/patients/gammaknife-treatment-process.html . Accessed August 9, 2016. Romanelli P, Morris DE, Adler JR Jr, Ewend MG. Image-guided robotic radiosurgery. In: Winn RH, ed. Youmans Neurological Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 257. Welling DB, Spear SA, Packer MD. Stereotactic radiation treatment of benign tumors of the cranial base. In: Flint PW, Haughey BH, Lund V, Niparko JK, ...
TY - JOUR. T1 - Stereotactic body radiotherapy (SBRT) for oligometastatic lung tumors from colorectal cancer and other primary cancers in comparison with primary lung cancer. AU - Takeda, Atsuya. AU - Kunieda, Etsuo. AU - Ohashi, Toshio. AU - Aoki, Yousuke. AU - Koike, Naoyoshi. AU - Takeda, Toshiaki. PY - 2011/11. Y1 - 2011/11. N2 - Purpose: To analyze local control of oligometastatic lung tumors (OLTs) compared with that of primary lung cancer after stereotactic body radiotherapy (SBRT). Materials and methods: Retrospective record review of patients with OLTs who received SBRT with 50 Gy in 5 fractions. Local control rates (LCRs), toxicities, and factors of prognostic significance were assessed. Results: Twenty-one colorectal OLTs, 23 OLTs from other origins, and 188 primary lung cancers were included. Multivariate analysis revealed only tumor origin was prognostically significant (p , 0.05). The 1-year/2-year LCRs in colorectal OLTs and OLTs from other origins were 80%/72% and 94%/94%, ...
Background: Although almost all dural arteriovenous fistulas (DAVFs) can be highly curable using endovascular treatment, some of them are reflactory. We evaluated the efficacy of stereotactic radiosurgery for DAVFs reflactory to endovascular treatment.. Methods: In 178 patients with DAVFs treated by endovascular embolization in our institution, 12 patients were reflactory and treated by CyberKnife (CK) radiosurgery. Patients background, efficacy of CyberKnife radiosurgery and complication were analyzed.. Results: 5 men and 7 women underwent CyberKnife radiosurgery. Ages ranged from 21 to 74 years (mean, 57.5 years). The locations of the fistulas were 10 transverse/sigmoid sinus and 2 cavernous sinus. The Borden classification was I in 3, II in 6, and III in 3 patients. Transarterial embolization (TAE) was performed in 10 patients, TAE and transvenous embolization (TVE) in 2. In all cases, shunt flow could be reduced, but small flow was residual. After embolization, residual fistula was treated ...
2. Lao L, Hope AJ, Maganti M, et al. Incidental prophylactic nodal irradiation and patterns of nodal relapse in inoperable early stage NSCLC patients treated with SBRT: A case-matched analysis. Int J Radiat Oncol Biol Phys 2014;90:209-215. 3. Timmerman R, Paulus R, Galvin J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA2010;303:1070-1076. 4. Dunlap NE, Yang W, McIntosh A, et al. Computed tomographyebased anatomic assessment overestimates local tumor recurrence in patients with mass-like consolidation after stereotactic body radiotherapy for early-stage nonesmall cell lung cancer. Int J Radiat Oncol Biol Phys 2012;84:1071-1077. 5. Faruqi S, Guiliani ME, Raziee H, et al. Interrater reliability of the categorization of late radiographic changes after lung stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 2014;89:10761083. 6. Timmerman R, Bastasch M, Saha D, et al. Optimizing dose and fractionation for stereotactic body radiation therapy. Normal
Purpose: : To evaluate the effectiveness of Leksell gamma knife treatment for choroidal melanoma not suitable for brachytherapy in terms of tumor control and resulting visual acuity. Methods: : Retrospective study of patients evaluated for uveal melanoma and found to be poor candidates for brachytherapy due to tumor thickness ,10 mm or proximity to optic disc. Patients who chose gamma knife over enucleation were referred for Leksell gamma knife where they received single fraction stereotactic radiation therapy of 20-25 Gy at the 50% isodose line. Follow-up was 2-77 months (mean = 34 months). Results: : In 11 of 12 (92%) patients, local control was achieved with tumor reduction. 1 patient died from metastatic disease. 3 of 12 (25%) patients had visual acuity better than 20/200 at last follow-up. Loss of visual acuity generally occurred due to radiation complications of therapy which were present in 8 of 12 (67%) patients. Conclusions: : Patients in this series had high rates of local control ...
Tagged: stereotactic ablative body radiation therapy. New Radiation Oncologist boosts skin and lung radiation capabilities, Stereotactic body radiation therapy plus chemotherapy improves survival, Lung Cancer and Radiation Therapy - Updates in Cancer Care Symposium Presentation, ARO selected as Australasian Training Site for Symmetry, Oligometastasis: a Curative Subset of Metastatic Disease, Extracranial Oligometastases: A Subset of Metastases Curable With Stereotactic Radiotherapy, Robotic image-guided reirradiation of lateral pelvic recurrences, Stereotactic radiation therapy in early stage NSCLC, New radiation therapy shows promise in lung cancer, Percutaneous spine stabilisation prior to stereotactic radiosurgery for high risk spinal metastases
PRIMARY OBJECTIVES:. I. The primary goal of this study is to estimate the rate of grade 3 or higher acute toxicities observed during a 6 month period following CyberKnife radiosurgery for gynecologic cancers.. II. To evaluate clinical response to radio-surgery for gynecologic tumors.. III. To assess general and site specific quality of life (using SF-12, FACT-En, FACT-O, FACT-Cx or FACT-V) and to evaluate patients level of pain.. SECONDARY OBJECTIVES:. I. As a secondary objective, toxicities during the 2 years following CyberKnife radiosurgery will also be described.. OUTLINE:. Patients undergo 3 fractions of CyberKnife stereotactic radiosurgery.. After completion of study treatment, patients are followed at 1, 3, 6, 12, 18 and 24 months. ...
TY - JOUR. T1 - SU‐GG‐T‐537. T2 - Dosimetric Effect of Residual Tumor Motion in Phase and Amplitude‐Based Gated Lung Stereotactic Body Radiotherapy. AU - Zhao, B.. AU - Yang, Y.. AU - Heron, D.. AU - Huq, M.. PY - 2010. Y1 - 2010. N2 - Purpose To evaluate dosimetric effect of residual tumor motion in lung Stereotactic Body Radiotherapy(SBRT) with two gating methods using external markers: amplitude‐(AG) and phase‐based(PG). Methods and Materials The 3D tumor motion data were obtained from the treatment logs of 6 lung patients with various target size, each treated with 3 fractions of SBRT using Cyberknife Robotic Radiosurgical System and Synchrony™(Accuray, Sunnyvale CA). Amplitude and phase‐based gating treatments were simulated with a gating window of 5 mm. Planning target volume(PTV) was defined as physician‐contoured clinical target volume(CTV) surrounded by isotropic 5 mm margin. Each patient was prescribed with 60Gy/3fractions prescribed to 80% isodose line which covered ...
Advances in imaging and biological targeting have led to the development of stereotactic body radiation therapy (SBRT) as an alternative treatment of extracranial oligometastases. New radiobiological concepts, such as ceramide-induced endothelial apo
This protocol is a single arm phase II multi-center trial evaluating the efficacy of Stereotactic Body Radiation Therapy (SBRT) in patients with oligometastatic non-small cell lung cancer (NSCLC) with response or stable disease after 4 cycles of first-line chemotherapy. The core hypothesis tested is that SBRT after 4 cycles of first-line chemotherapy is feasible, safe, provides durable local control of treated lesions and improves time to progression compared to historical controls. Patients are eligible for enrollment if they have metastatic NSCLC with ≤5 lesions amenable to SBRT ...
The effect of radiosurgery on spontaneous haemorrhage into metastatic brain tumours has not been sufficiently investigated. This study showed that haemorrhage was observed in 7.4% of patients (3.8% of tumours) before radiosurgery and in 18.5% of patients (7.6% of tumours) after radiosurgery. This would not necessarily imply that radiosurgery increases the likelihood of haemorrhage, as the incidence of intratumour haemorrhage is quite different between the early and later stages of brain metastases, which grow very rapidly. Rather, the incidence of haemorrhage after radiosurgery (18.5%) was no greater than that of untreated tumours reported previously (0-50%).3 However, it is not possible to state definitively whether radiosurgery increases, does not change, or decreases the risk of haemorrhage, because of the lack of a control group. However, 50% of the observed haemorrhages occurred within one month of the procedure. As most haemorrhagic tumours were under good local control at the time of the ...
Douglas Kondziolka, MD, a researcher and neurosurgeon at the NYU Langone Medical Center in New York City, who has performed many thousands of Gamma Knife procedures, said: "Gamma Knife radiosurgery is an excellent example of how evolving cancer care technologies are addressing growing demand for precision medicine, where treatments can be precisely tailored to an individuals unique anatomy and biologic makeup while simultaneously helping to reduce the risk of damaging healthy tissue. As one of the most comprehensively studied tools in the neurosurgery armamentarium, we can confidently offer this treatment option as a minimally invasive alternative to traditional brain surgery or whole brain radiation therapy for properly selected patients.". Using up to 192 precisely focused sources of radiation, Gamma Knife can be used to control both malignant and nonmalignant tumors, as well as for treating arteriovenous malformations, essential tremor and trigeminal neuralgia while limiting damage to ...
Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or liver metastases. The purpose of this study was to investigate the efficacy and safety of SBRT for lung and liver oligo-recurrent lesions and evaluate predictive factors for local control and prognosis. This retrospective study included patients who presented with 1-3 matachronous lung or liver metastases, and treated with SBRT between May 2013 and March 2016 at a single institution. All patients harbored a controlled primary lesion. Patients with | 6 months of follow-up were excluded. Local control, progression free survival, and overall survival rates were analyzed according to the Kaplan-Meier product limit method. Univariable log-rank and multivariable Cox regression analyses were performed to clarify predictive factors for local control and prognosis. Toxicity was graded according to the Common
Purpose: Accurately localizing lung tumor localization is essential for high-precision radiation therapy techniques such as stereotactic body radiation therapy (SBRT). Since direct monitoring of tumor motion is not always achievable due to the limitation of imaging modalities for treatment guidance, placement of fiducial markers on the patients body surface to act as a surrogate for tumor position prediction is a practical alternative for tracking lung tumor motion during SBRT treatments. In this work, the authors propose an innovative and robust model to solve the multimarker position optimization problem. The model is able to overcome the major drawbacks of the sparse optimization approach (SOA) model. Methods: The principle-component-analysis (PCA) method was employed as the framework to build the authors statistical prediction model. The method can be divided into two stages. The first stage is to build the surrogate tumor matrix and calculate its eigenvalues and associated eigenvectors. ...
This phase I study will investigate the safety of Sorafenib and Bavituximab plus Stereotactic Body Radiation Therapy (SBRT) in the treatment of unresectable
This trial is assessing the efficacy and tolerability of erlotinib (Tarceva) in combination with stereotactic body radiation therapy (SBRT) in patients with
What to expect when receiving Stereotactic Body Radiation Therapy (SBRT), including treatment process, side effects and resources for patients.
Stereotactic body radiation therapy via helical tomotherapy to replace brachytherapy for brachytherapy-unsuitable cervical cancer patients – a preliminary result Chen-Hsi Hsieh,1–3 Hui-Ju Tien,1 Sheng-Mou Hsiao,4 Ming-Chow Wei,4 Wen-Yih Wu,4 Hsu-Dong Sun,4 Li-Ying Wang,5 Yen-Ping Hsieh,6 Yu-Jen Chen,3,7–9 Pei-Wei Shueng1,101Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, 3Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 6Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, Taiwan; 7Department of Radiation Oncology, 8Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; 9Graduate Institute of
A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-centre, International Study of Durvalumab With Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515)
In todays era, India has become the most coveted option for international patients who are looking for quality treatment, excellent services and hospitality at affordable price, due to which India is gaining immense popularity in field of medical tourism at global level. It is estimated that the cost of gamma knife surgery in India is almost half or less than half the cost of similar procedure in developed countries, which makes it highly advantageous for medical tourists. Many cities like Delhi, Mumbai, Bangalore , Pune ,Chennai( and many more) offer gamma knife radiosurgery and the hospitals which cater this treatment are well equipped with state of the art facilities and highly skilled and experienced health care professionals who not only treat the patients disease with greatest care and professionalism but also makes them feel at home ...
Non-invasive stereotactic body radiation therapy (SBRT), which precisely delivers a high-dose beam of radiation to target tumors while minimizing dose to the surrounding healthy tissue, is...
Stereotactic body radiation therapy for metastases to the kidney in patients with non-small cell lung cancer: a new treatment paradigm for durable palliation
Background: Radiosurgery clinical practice relays on empirical observations and the experience of the practitioners involved in determining and delineating the target and therefore variability in target delineation might be expected for all the radiosurgery approaches, independent of the technique and the equipment used for delivering the treatment. The main aim of this study was to quantify the variability of target delineation for two radiosurgery targets expected to be difficult to delineate. The secondary aim was to investigate the dosimetric implications with respect to the plan conformity. The primary aim of the study has therefore a very general character, not being bound to one specific radiosurgery technique.. Materials and methods: Twenty radiosurgery centers were asked to delineate one cavernous sinus meningioma and one astrocytoma and to plan the treatments for Leksell Gamma Knife Perfexion. The analysis of the delineated targets was based on the calculated 50% agreement volume, ...
Now University of Virginia (UVA) is offering the latest and most advanced technology in stereotactic radiosurgery, called Gamma Knife eXtend, which allows physicians to treat larger tumours, multiple tumours and tumours near sensitive structures like the brainstem, facial nerves or the optic nerve. UVAs Lars Leskell Center for Gamma Knife Radiosurgery is the first in the United States and the second worldwide to offer the eXtend system.. "This technology expands our ability to treat patients with radiosurgery in ways we would not have thought possible five or 10 years ago", stated Jason Sheehan, MD, PhD, FACS, associate professor of neurosurgery and radiation oncology at the UVA School of Medicine. Jason Sheehan, co-director of the Center for Gamma Knife Radiosurgery, conducted radiosurgery using the eXtend system in mid-January. This was the first stereotactic radiosurgery of this type in the nation.. UVA neurosurgeons and radiation oncologists are pioneers in this field and have used Gamma ...
The task group (TG) for quality assurance for robotic radiosurgery was formed by the American Association of Physicists in Medicine s Science Council under the direction of the Radiation Ther- apy Committee and the Quality Assurance (QA) Subcommittee. The task group (TG-135) had three main charges: (1) To make recommendations on a code of practice for Robotic Radiosurgery QA; (2) To make recommendations on quality assurance and dosimetric verification techniques, especially in regard to real-time respiratory motion tracking software; (3) To make recommendations on issues which require further research and development. This report provides a general functional overview of the only clinically implemented robotic radiosurgery device, the CyberKnifeVR . This report includes sections on device components and their individual component QA recommendations, followed by a section on the QA requirements for integrated systems. Examples of checklists for daily, monthly, annual, and upgrade QA are given as ...
MCQS STEREOTACTIC RADIOSURGERY STEREOTACTIC RADIOSURGERY PLAB, IELTS, USMLE, GRE, AIPGMEE, AIIMS, AFMC, BHU, CMC, JIPMER, PGI, SGPGI, ...