New therapies and treatment protocols have led to improved survival rates in many cancers. The improved rates are such that patients are now living long enough to experience some negative long-term side effects of the initial therapy. We report the case of a 65-year-old Caucasian woman who presented with a rare case of pseudotumoral radionecrosis, a late radiation-induced injury, after combined surgical and cobalt radiation therapy for the treatment of adenocarcinoma of the right breast. The patient underwent resection of this benign, yet progressively growing and painful tumor. A cosmetically satisfying result was achieved by reconstruction of the thoracic wall with a polypropylene mesh and a latissimus dorsi muscle flap. With improved overall survival, new management strategies for late side effects of therapy are becoming of crucial importance for affected patients. In the future, improving toxicity-free survival will be as important as achieving disease-free survival or local tumor control.
Radiation fibrosis is a scarring of tissues around the site of exposure to radiation. The presence of the scar tissue can reduce your range of motion.
Radiation necrosis: Find the most comprehensive real-world symptom and treatment data on radiation necrosis at PatientsLikeMe. 19 patients with radiation necrosis experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Bevacizumab, Physiotherapy, and Therapeutic brace to treat their radiation necrosis and its symptoms.
radiation injury: Tissue damage or changes caused by exposure to ionizing radiation -namely, gamma rays, X-rays, and such high-energy particles as neutrons, electrons, and positrons. Sources of...
Approximately 30-40% of patients develop a deterioration of visual acuity within 5 years after treatment of uveal melanoma using radiation therapy and TTT due to radiation retinopathy (Shields 2002, Bartlema 2003). By administration of either Lucentis® or Triamcinolone® we hope to treat complications of radiation therapy, by demonstrating a statistically significant improvement in visual acuity and a reduced amount of macular edema and vascular leakage. Additionally, we hope to obtain a better understanding of the pathophysiologic processes involved, by demonstrating a possible relation between high levels of angiogenic factors (VEGF) in the anterior chamber fluid, and radiation retinopathy. In conclusion, we hope to provide evidence for a new therapy in patients with retinopathy, due to radiation in uveal melanoma. There is no scientifically proven treatment available at this time ...
Principal Investigator:YOSHIDA Masanori,木村 浩彦, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Radiation science
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
When brain tumors are treated with radiation therapy, there is always a risk of radiation-induced necrosis of healthy brain tissue. Insidious and potentially fatal, radiation necrosis of the brain may develop months or even years after irradiation. This poorly understood side effect can occur even when the most stringent measures are taken to avoid exposing healthy tissue to harmful levels of radiation. In most cases, radiation necrosis of the brain occurs at random, without known genetic or other predisposing risk factors. The only treatment options typically available for radiation necrosis of the brain are surgery to remove dead tissue and use of the steroid dexamethasone to provide limited symptom control. But clinicians have not found a way to stop the progression of necrosis, despite having tested a range of therapies including anticoagulants, hyperbaric oxygen, and high-dose anti-inflammatory regimens. However, recent studies at M. D. Anderson have shown that the monoclonal antibody ...
Directly inhibiting the activity of a key protein mediator of inflammation reduced radiation toxicity in zebrafish embryos, and may ultimately be of help to patients receiving radiation therapy, according to researchers from ...
TY - JOUR. T1 - Accessory neuropathy after high-dose radiation therapy for tongue-base carcinoma [1]. AU - Mizobuchi, Keiko. AU - Kincaid, John. PY - 2003/11/1. Y1 - 2003/11/1. UR - http://www.scopus.com/inward/record.url?scp=0242268481&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0242268481&partnerID=8YFLogxK. U2 - 10.1002/mus.10456. DO - 10.1002/mus.10456. M3 - Letter. C2 - 14571473. AN - SCOPUS:0242268481. VL - 28. SP - 650. EP - 651. JO - Muscle and Nerve. JF - Muscle and Nerve. SN - 0148-639X. IS - 5. ER - ...
Radiation therapy - MedHelps Radiation therapy Center for Information, Symptoms, Resources, Treatments and Tools for Radiation therapy. Find Radiation therapy information, treatments for Radiation therapy and Radiation therapy symptoms.
White rats were irradiated by both 131iodine, which was incorporated into the thyroid gland, and 137cesium; these were dosed at about 10 and 6 Gy, respectively. A portion of the experimental animals w
As atomic radiation permeates living tissues, highly-organized units of living matter in the cell are disrupted. Fundamentally, the cell is composed of atoms and molecules which are split by radiation into electrically-charged fragments. This ionization process is completed in less than a trillionth of a second, yet it triggers off a chain reaction of subtle events within the cell leading to its damage or eventual death. Since cells are not inert blobs of matter but living, reproducing, organisms, they react to the radiation-induced injury by repair processes which lead to apparent recovery. If the radiation dose is overwhelming, immediate or only slightly delayed death of the cell ensues when the cell attempts to divide.. Radiation also harms cells by producing changes in the environment. Cells are bathed by solutions from which radiation-produced activated products can reach and damage them. Also, cells can be damaged by interference with their blood supply and the action of poisonous products ...
Hi! Well... my PET Scan showed no PET activity in the lungs and some small amount of activity in my colon. I have not yet met with the Doc to discuss results yet as the day following the PET scan they found on an angiogram I had a blocked vein in my chest which they later found out to be stenosis caused from prior radiation to the chest. I was hospitalized in ICU for 6 days and was only released about 10 days ago. They theorize that somehow the vein was in the field of radiation and over time developed radiation fibrosis. Great! Well, they did an angioplasty in an attempt to open it up, but this was only partially successful. The vein could not be stented due to the pacemaker wires running thru it and the risk of tearing the vein with the stent while on blood thinners. In the end the Docs told me my body was in the process of making colateral veins which would at some point relieve some of the swelling in the left arm and chest.. I meet with my Doc on the PET scan and CT results on Thursday of ...
RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer.. PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery. ...
Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.. Proc Natl Acad Sci U S A. 2004 ...
Get the latest radiation monitoring (monitoring and testing) news on Environmental XPRT, the worlds largest environmental industry marketplace and information resource.
Precisely targeted radiation therapy can eradicate all evidence of disease in selected patients with cancer that has spread to only a few sites, suggests the first published report from an ongoing clinical trial. Radiation therapy controlled all signs of cancer in 21 percent of patients who had five or fewer disease sites.
A helpful article explains what radiation therapy is and how it can be used in treatment for cancer. Radiation therapy is one of the most difficult areas to understand and cope with.
Radiation therapy can destroy tumors and/or prevent them from returning. It can be used by itself as the only treatment or in combination with surgery, chemotherapy, or both. Learn more about the types of radiation therapy and how its used at MSK.
Radiation therapy is delivered differently depending on the type of cancer and stage of treatment. The types of radiation treatment we provide are listed here.
The Mabry Center is a local outpatient cancer care facility offering the latest radiation technology & committed to cancer research by providing clinical trials.
Radiation therapy through Regions Hospital is one of the main treatments for cancer and may be recommended as part of an integrated cancer treatment strategy.
Learn more about Intensity Modulated Radiation Therapy at Grand Strand Medical Center DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your...
For the first time, AI has been used to accurately predict side effects associated with radiation therapy for head and neck cancer.
Hello everyone, patient come in to the hospital for radiation treatment. Physician bill 77427 . what is the code should I use for hospital reimburseme
Health,Switching off a mammalian protein called Rad9 could hold the key to ki... That is why reserachers are now looking at Rad9 with renewed inter...,Switching,Off,Protein,Could,Play,Key,Role,In,Success,Of,Radiation,Therapy,For,Cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of the colon after exposure to x-rays or other ionizing radiation as a part of radiation therapy. Radiation proctitis most commonly occurs after treatment for cancers such as cervical cancer, prostate cancer, and colon cancer. Radiation proctitis involves the lower intestine, primarily the sigmoid colon and the rectum and is part of the conditions known as pelvic radiation disease and radiation enteropathy. Radiation proctitis can occur at two times after treatment: Acute radiation proctitis - symptoms occur in the first few weeks after therapy. These symptoms include diarrhea and the urgent need to defecate, often with pain while doing so (tenesmus). Acute radiation proctitis usually resolves without treatment after several months, but symptoms may improve with butyrate enemas. This acute phase is due to direct damage of the lining (epithelium) of the colon. Chronic radiation proctitis - is a ...
Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) - Pipeline Review, H1 2017, provides an overview of the Radiation Toxicity (Radiation Sic
Radiation enteropathy or radiation enteritis is a syndrome that may develop following abdominal or pelvic radiation therapy for cancer. Many affected people are cancer survivors who had treatment for cervical cancer or prostate cancer; it has also been termed pelvic radiation disease with radiation proctitis being one of the principal features. People who have been treated with radiotherapy for pelvic and other abdominal cancers frequently develop gastrointestinal symptoms. These include: rectal bleeding diarrhea and steatorrhea other defecation disorders including fecal urgency and incontinence. nutritional deficiencies and weight loss abdominal pain and bloating nausea, vomiting and fatigue Gastrointestinal symptoms are often found together with those in other systems including genitourinary disorders and sexual dysfunction. The burden of symptoms substantially impairs the patients quality of life. Nausea, vomiting, fatigue and diarrhea may happen early during the course of radiotherapy. ...
Purposes: Intestinal complications after radiotherapy are caused by transmural fibrosis and impair the quality of life of cancer survivors. Radiation fibrosis was considered permanent and irreversible, but recently, its dynamic nature was shown, providing new opportunities for the development of antifibrotic therapies. Among these new targets, we identified the Rho/ROCK pathway and thought to investigate whether pravastatin treatment inhibits Rho pathway activation and elicits an antifibrotic action. Experimental Design: Rho and ROCK activities were monitored in human explants presenting radiation fibrosis remodeling after incubation with pravastatin. Subsequent modulation of CCN2, type I collagen, and fibronectin expression were assessed ex vivo and in intestinal smooth muscle cells derived from radiation enteropathy. Then, the therapeutic relevance of the antifibrotic action of pravastatin was explored in vivo in a rat model of chronic radiation fibrosis (19 Gy X-rays) treated with 30 mg/kg/d ...
Acute Enteritis, in most cases is defined as a condition of inflammation of the small intestine as a result of eating and drinking contaminated water and foods infected by virus and bacteria. But according to the study by the University Hospital Aintree, chronic radiation enteritis is an increasing problem, as more patients receive radiotherapy as part of their cancer therapy and as the long-term survival of these patients improves(a). Other study indicated that acute radiation enteritis is almost inevitable in the curative treatment of malignant tumors of the abdomen and pelvic area. It is frequently a self-limiting disorder of intestinal function associated with reversible mucosal changes of the intestine(b). The prevalence of the disease although is decreasing, it still affects millions (approx 1 in 83 or 1.20% or 3.3 million people in USA ) of people in the U.S alone, according to the statistic. Chronic enteritis is a condition of inflammation caused by other health conditions, such as ...
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Purpose: Patients undergoing radiotherapy (RT) for left-sided breast cancer have increased risk of coronary artery disease. Deep Inhalation Breath Hold assisted RT (DIBH-RT) is shown to increase the geometric separation of the target area and heart, reducing cardiac radiation dose. The purposes of this study are to use Cine MV portal images to determine the stability of spirometer-guided DIBH-RT and examine the dosimetric cardiopulmonary impact of this technique. Methods: Twenty consecutive patients with left-sided breast cancer were recruited to the IRB-approved study. Free-breathing (FB) and DIBH-CTs were acquired at simulation. Rigid registration of the FB-CT and DIBH-CT was performed using primarily breast tissue. Treatment plans were created for each FB-CT and DIBH-CT using identical paired tangent fields with field-in-field or electronic compensation techniques. Dosimetric evaluation included mean and maximum (Dmax) doses for the left anterior descending artery (LAD), mean heart dose, and ...
Types of radiation therapy include external beam radiation therapy, particle therapy, brachytherapy, radioisotope therapy and more. See below for local oncologists and other specialists in Belton that give access to radiation therapy as well as advice and content on radiation oncology and cancer treatment.
Types of radiation therapy include external beam radiation therapy, particle therapy, brachytherapy, radioisotope therapy and more. See below for local oncologists and other specialists in Ames that give access to radiation therapy as well as advice and content on radiation oncology and cancer treatment.
Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.
Because the management of cervical cancer is stratified by tumour stage, we undertook this retrospective study to analyse the clinical characteristics and postoperative outcomes for inpatients with CRE requiring surgery after RRT or RS plus RT. In this series of 166 consecutive cases of CRE requiring surgery, more patients suffered from radiation-induced fistula, perforation and proctitis in the RRT group. An aggressive intestinal resection procedure was performed in almost all of the cases with overall and major morbidity rates of 63.9 % and 14.5 %, respectively. Although the surgical procedure is very difficult in patients with CRE, extensive resection of irradiated bowel is suitable and feasible with acceptable postoperative outcomes.. Radiation induced digestive stenosis, which was responsible for complete or incomplete obstruction, was the most common symptom and surgical indication (81.9 %); this finding is consistent with the previous literature [21-23]. Concerning the site of ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Radiation therapy, or radiotherapy, is a common way to treat cervical cancer. With any treatment of cancer you must first understand your responsibility and your medical teams role as well as explore treatment options and get a second opinion(s) before you begin treatment. Since the side effects of radiation can be significant, talk to your doctor prior to treatment so that you understand the specific kind of radiation you will receive and the expected side effects. Doctors who specialize in treating cancers with radiation are known as radiation oncologists. During radiation therapy, high-energy x-rays are used to kill cancer cells. Radiation therapy can be given by a machine that aims x-rays at the body (external beam radiation) or by placing small capsules of radioactive material directly into the cervix (internal or implant radiation or brachytherapy). Many patients receive both kinds of radiation therapy. For stage I cervical cancer, radiation therapy may be used instead of surgery or it ...
Late Radiation Morbidity Incidence in a South-East Scottish cohort and investigation into abnormalities in DNA double-strand break repair and damage ...
Spontaneous genetic abnormalities occur with surprising regularity. Depending on the source of information, the rate for spontaneous genetic abnormalities is approximately 5 to 10%. Radiation increases the risk of genetic abnormalities. Radiation induced genetic abnormalities are indistinguishable from those that occur naturally. There are no changes that can be attributed to radiation effects that cannot be seen in naturally occurring genetic abnormalities. At what rate do radiation induced genetic abnormalities occur, and with what levels of exposure? It has been estimated that by exposing the gonads directly to 10 Rads of radiation (twice the amount of radiation that a radiation worker can be legally exposed to over the period of a year) over a short period of time (seconds to minutes) there would be an increase in the incidence of genetic abnormalities by approximately 0.005% to 0.075%. This translates to an increase risk of genetic abnormalities of between 1 in 1,300 to 1 in 20,000. Without ...
Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. The aim of this thesis was to develop PKPD models of anticancer drugs for tumour effects and haematological toxicity, which is the most frequent dose-limiting toxicity.. PK and haematological toxicity after several schedules were studied in rats and semi-physiological PKPD models for the whole time course of myelosuppression were developed from animal and patient data. The possibility to implant hollow fibres filled with tumour cells in immunocompetent rats was investigated for simultaneous assessment of PK, tumour response and haematological toxicity. Population data analyses were performed using the software NONMEM. When all injections were ...
... (in American English), radiation oncology, or radiotherapy (in the UK, Canada and Australia), sometimes abbreviated to XRT or DXT, is the medical use of ionizing radiation, generally as part of cancer treatment to control or kill malignant cells. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of curative therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of exposed tissue leading to cellular death. To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams are ...
... ™ Development. NCCN develops the NCCN Radiation Therapy Compendium™ based upon each multidisciplinary Guidelines Panels evaluation of available scientific evidence, including published literature and the expert judgment of the panel members. The widely accepted NCCN Categories of Evidence and Consensus score individual NCCN Radiation Therapy recommendations. Conversion into the NCCN Radiation Therapy Compendium™ occurs by extracting data directly from the NCCN Guidelines. Radiation Therapy information may be present within the algorithm and footnotes on Guidelines pages as well as in appendices and "Principles of Radiation Therapy" pages included in selected Guidelines. Discretization into disease and radiation therapy-related elements within a database follows data extraction. Select Guidelines panel members (e.g. chair, vice-chair and radiation oncologist) then review this database content for accuracy on a Guideline-by-Guideline basis. The NCCN ...
came home from work with a head full of thoughts about radiation injury and I went for a walk with my son. And it was just an example of how happenstance tends to be the source of invention sometimes. So Ronan and I go out with Cora my dog and we were walking and we bumped into another dog and the owner of the other dog asked me what I did for a living and I told him I was a radiologist I did research. He asked what research I did and explained to him that I was working on the issue of radiation injury and looking into antioxidants and he said I make antioxidant. It turns out this man was Ivan de Souza and he made an antioxidant called Urate. So we began to use this in our experiments and initially we used an eyedropper essentially and took some peripheral mononuclear cells from pigs and radiated them in a cellar radiator and then applied topical antioxidant. And we found we could decreased DNA breaks. Then we went on to feed the pig antioxidants and then radiate their blood and get a more in ...
Object. Radiation necrosis is the only significant complication of gamma knife surgery (GKS). The authors studied treatment plan parameters in patients who had radiation necrosis to determine if risk factors for necrosis could be identified.. Methods. Between September 1994 and December 1998, 286 patients were treated with GKS by the senior author. Of the 243 patients who were suitable for analysis, 17 developed radiation necrosis and were prospectively followed. Concurrently, 17 patients without necrosis were randomly selected as case controls on the basis of histological findings in their lesions. Integral dose-volume histograms (DVHs) were calculated and dose-volume treatment parameters were determined. A comparison was made with both the established Kjellberg and Flickinger isonecrosis risk lines. Clinical outcome was assessed according to time to resolution of symptoms and return to normal radiographic appearance.. Conclusions. Treatment plan variables associated with the risk of necrosis ...
The progress that has been made in the treatment of colon cancer has resulted from improved development of radiation treatments and surgical techniques and participation in clinical trials. Future progress in the treatment of colon cancer will result from continued participation in appropriate clinical trials. Currently, there are several areas of active exploration to improve radiation treatment of colon cancer.. New Radiation Therapy Modalities: Some radiation oncology centers have special treatment equipment for certain circumstances. For small early cancers, a focused radiation beam can be aimed directly at the cancer in the colon. Intra-operative radiation therapy (IORT) refers to treatment in a specially equipped operating room where a single dose of radiation is given during surgery. The radiation doctor is able to see the area being treated directly and move sensitive normal structures, such as the small bowel, away from the radiation beam. IORT is usually administered when surgery is ...
Azria, D, Magne, N, Zouhair, A, Castadot, P, Culine, S, Ychou, M. "Radiation recall: A well recognized but neglected phenomenon". Cancer Treatment Reviews. vol. 31. 2005. pp. 555-570. (The authors provide an overview of the topic based upon a literature review composed of full text articles (abstracts only excluded) published in English, regardless of publication date. The dermatologic reaction can occur when the inciting agent is administered even years after the radiation exposure. The resultant reaction generally has sharply demarcated edges consistent with the previously irradiated field and can range from erythema to necrosis. Based upon this review of the literature, the various hypotheses regarding the etiology of this phenomenon were outlined. The authors state that the precise etiology is poorly understood and difficult to reproduce even in animal models. Hypotheses regarding the possible causes include a "remembered" reaction in the remaining surviving cells within the previously ...