Although adolescent and adult rats with an NVHL did not show reduced levels of GAD67 or PV, their PFC interneurons had abnormal dopaminergic modulation. The D2 agonist quinpirole failed to increase cell excitability in FSIs and NFS interneurons from adult rats with an NVHL, and, in many cases, the neurons showed an abnormal decrease in excitability. The lack of activation of GABA interneurons by quinpirole was also reflected in the absence of a late, GABAA-dependent component in the D2 modulation of synaptic responses within the PFC in slices from NVHL rats. The data suggest that the periadolescent maturation of interneuron function is altered in NVHL rats, even if there is no actual loss of this cell population.. The use of a lesion as a schizophrenia model does require some clarification. If the model has any claim to construct validity, it cannot reside in the lesion as schizophrenia patients to not present a lesion. Because many studies suggest an abnormal PFC in NVHL rats and inactivating ...

Bono F, Savoia P, Guglielmi A, Gennarelli M, Piovani G, Sigala S, Leo D, Espinoza S, Gainetdinov RR, Devoto P, Spano P, Missale C, Fiorentini C. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Mol Neurobiol. 2018 02; 55(2):1054-1067 ...

Upon treatment with SKF-38393 (1 nm) or quinpirole (100 nm) for 72 h or 7 d, we observed a significant decrease in the colocalization between GABAA receptor β2/3 subunit clusters expressed at the cell-surface and VIAAT-1-positive presynaptic terminals: 79.6 ± 3.0% of surface β2/3 subunit clusters, which were colocalized with VIAAT-1 puncta in control cultures (7 DIV), was significantly decreased to 50.1 ± 3.7% (p , 0.01, paired t test, n = 26) by 72 h treatment with SKF-38393, or to 49.8 ± 3.6% (p , 0.01, paired t test, n = 21) by 72 h treatment with quinpirole (Fig. 2C,E). Similarly, a prolonged 7 d treatment of cells (from 7 to 14 DIV) with either of the agonists resulted in a significant decrease in colocalization between β2/3 subunit clusters and VIAAT-1-positive presynaptic terminals: 90.6 ± 1.2% colocalization observed in control vehicle-treated cells was significantly reduced to 68.0 ± 2.4% (p , 0.01, paired t test, n = 24) by SKF-38393, and to 70.0 ± 3.0% (p , 0.01, paired t ...

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TY - JOUR. T1 - D2-like dopamine receptors promote interactions between calcium and chloride channels that diminish rod synaptic transfer in the salamander retina. AU - Thoreson, Wallace B.. AU - Stella, Salvatore L.. AU - Bryson, Eric J.. AU - Clements, John. AU - Witkovsky, Paul. PY - 2002/5/1. Y1 - 2002/5/1. N2 - Activation of D2-like dopamine receptors in rods with quinpirole stimulates L-type calcium currents (ICa). This result appears inconsistent with studies showing that D2-like dopamine receptor activation diminishes rod signals in second-order retinal neurons. Since small reductions in [Cl-]i can inhibit photoreceptor ICa, we tested the hypothesis that enhancement of ICa, with the D2/D4 receptor agonist, quinpirole, increases calcium-activated chloride currents (ICl(Ca)) causing an efflux of Cl- from rods that would provide a negative feedback inhibition of ICa. In agreement with studies from Xenopus, quinpirole reduced rod input to second-order neurons of tiger salamander retina ...

RESULTS: T lymphocytes expressed all the five subtypes of dopamine receptor mRNAs, i.e., D1, D2, D3, D4 and D5 receptors. SKF38393, an agonist of dopamine D1-like receptors (D1 and D5 receptors) only reduced the IFN-γ production, but did not significantly affect the proliferative response, IL-4 production, cAMP content or CREB activation of the lymphocytes. The SKF38393-induced decrease in IFN-γ level was blocked by the D1-like receptor antagonist SCH23390. Quinpirole, an agonist of dopamine D2-like receptors (D2, D3 and D4 receptors) attenuated the lymphocyte proliferation to Con A, and decreased the IFN-γ but increased the IL-4 production. Meanwhile, the quinpirole diminished the cAMP content and the phosphorylated CREB level in the lymphocytes. All the quinpirole-induced changes were reversed by dopamine D2-like receptor antagonist haloperidol ...

Dopamine and the excitatory amino acids play important roles in the control of motor behavior by the basal ganglia; elucidating the manner in which these transmitter systems interact may provide new therapeutic approaches to the treatment of movement disorders such as Parkinsons disease. The 2-deoxyglucose autoradiographic technique was used to examine the effect of N-methyl-D-aspartate receptor blockade on regional cerebral metabolic responses to D1 and D2 dopamine receptor stimulation in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. The D1 agonist SKF 38393 (5 mg/kg, i.v.) increased glucose utilization markedly in entopeduncular nucleus and substantia nigra pars reticulata ipsilateral to the lesion, while the D2 agonist quinpirole (1 mg/kg, i.v.) had no effect in these striatal output regions. SKF 38393 and quinpirole reduced 2-deoxyglucose uptake to a similar extent in the lateral habenula, a region which receives afferent input from entopeduncular nucleus; quinpirole

Daily injection of methamphetamine (MAP) increased the locomotor activity and produced the development of MAP-induced anticipatory activity on the next withdrawal day. Daily restricted feeding also causes a feeding-associated anticipatory activity rhythm. The importance of catecholaminergic neurons has been suggested in the manifestation of a feeding-associated corticosterone rhythm. In our study, we examined the role of dopaminergic neurons in the development of MAP-induced anticipatory activity. The development of MAP-induced anticipatory activity was blocked by coadministration of dopamine D2 receptor antagonists such as YM-09151-2 and sulpiride, the D1 receptor antagonist SCH23390 and haloperidol weak D1/D2 receptor antagonist, but not by clozapine. The anticipatory activity increase was reproduced by daily injection of the D2 receptor agonist quinpirole as well as moderately by the D1 receptor agonist SKF38393. Moreover, MAP-induced anticipation was blocked by coadministration of the ...

We next investigated whether beta gamma subunits play a role in the sensitization of type VI adenylyl cyclase activity; using expression of alpha tau to inhibit beta gamma-mediated effects, we found that the quinpirole-induced sensitization of type VI adenylyl cyclase was abolished ...

The involvement of dopaminergic mechanisms in modulating ganglionic transmission of the dog cardiac sympathetic ganglia were investigated in both in vivo and in vitro experiments. The positive chronotropic responses to preganglionic stellate stimulation were inhibited by R(+)SK&F38393 and talipexole administered directly to the ganglia through the artery, and the inhibitory effects were antagonized by pretreatment with R(+)SCH23390 and S(-)sulpiride, respectively. McN-A-343 and 1,1-dimethyl-4-phenylpiperazinium iodide given through the artery to reach the ganglia displayed dose-dependent positive chronotropic effects. The positive chronotropic effects were inhibited by (-)quinpirole and talipexole, but not by R(+)SK&F38393. The inhibitions were antagonized by S(-)sulpiride and tended to be antagonized by yohimbine. The acetylcholine output from the isolated stellate ganglia by preganglionic stimulation (5 Hz) was unaffected in the presence of (-)quinpirole and talipexole, but was ...

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TY - JOUR. T1 - Modulation of lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production by dopamine receptor agonists and antagonists in mice. AU - Haskó, G.. AU - Szabó, C.. AU - Merkel, K.. AU - Bencsics, A.. AU - Zingarelli, B.. AU - Kvetan, V.. AU - Vízi, E.. PY - 1996/3. Y1 - 1996/3. N2 - The effects of various agonists and antagonists of dopamine D1 and D2 receptors on lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) and nitric oxide (NO) production was investigated in mice. Pretreatment of animals with bromocryptine or quinpirole, agonists of dopamine D2 receptors caused a blunting of both the TNF-α and MO responses to LPS injected intraperitoneally. Sulpiride, an antagonist of dopamine D2 receptors, decreased the LPS-induced TNF-α plasma levels in a dose-dependent manner and inhibited the LPS-induced NO production by peritoneal macrophages. Bromocryptine or quinpirole blunted both the TNF-α and NO response to LPS. SCH-23390, an antagonist of ...

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Gov't, P.H.S. MeSH Terms 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology Animals Benzazepines/pharmacology Dopamine Agonists/pharmacology Dopamine Antagonists/pharmacology. Dose-Response Relationship, Drug Eating/drug effects Ergolines/pharmacology Food Deprivation/physiology. Haloperidol/pharmacology Male Naltrexone/pharmacology Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1/drug effects. Receptors, Dopamine D2/drug effects Substances Benzazepines Dopamine Agonists. Pairing naltrexone with SKF-38393 produced reductions of deprivation-induced intake comparable to that of naltrexone alone. Keywords Food deprivation; Naltrexone; SKF-38393; SCH-23390; Quinpirole; Haloperidol; Opioids; D1 Receptor; D2 Receptor Copyright 1994 Published by Elsevier Inc.. Dopamine Antagonists Ergolines Receptors, Dopamine D1 Receptors, Dopamine D2. Quinpirole Naltrexone 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Haloperidol Grant Support DA04194/DA/NIDA NIH ...

Parlodel is in a group of drugs called dopamine receptor agonists. It has some of the same effects as a chemical called dopamine, which occurs naturally in your body ...

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L-Tyrosine BackgroundL-Tyrosine is an amino acid found that is involved in the production of neurotransmitters like dopamine, adrenaline, and noradrenaline (see figure 1).Figure 1 Scientific effectsTyrosine has numerous studies in humans showing a variety of effects. One study by the U.S. Army Research Institute of Env

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The present study indicates that activation of dopamine D1-like receptors by administration of SKF 38393 leads to dose-dependent (doses: 5, 10 and 20 mg/kg) increases in the expression of cFos proteins in the rat paraventricular nucleus of the hypothalamus (PVN). This effect was abolished by administration of SCH 23390, a dopamine D1-like receptor antagonist (0.5 and 1 mg/kg, given 30 min before SKF 38393--10 mg/kg), suggesting that the apparent effect is specific for activation of dopamine D1-like receptors. Expression of cFos after SKF 38393 (10 mg/kg) was observed in some, but not all, CRF-immunoreactive neurons, as well as in small portion of oxytocin- but not vasopressin-immunoreactive neurons (double-immunofluorescence experiments). There were also certain populations of nuclei that showed expression of cFos but did not co-localize with the above markers. We also found that both acute and repeated (once daily for 5 consecutive days) exposure to cocaine (25 mg/kg) attenuated the induction of cFos

TY - JOUR. T1 - Does Dopamine Act at Dopamine Receptors in the Ciliary Epithelia?. AU - Wax, M. B.. PY - 1993/3/1. Y1 - 1993/3/1. UR - http://www.scopus.com/inward/record.url?scp=0027526563&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027526563&partnerID=8YFLogxK. U2 - 10.1006/exer.1993.1048. DO - 10.1006/exer.1993.1048. M3 - Editorial. C2 - 8472793. AN - SCOPUS:0027526563. VL - 56. SP - 371. EP - 373. JO - Experimental Eye Research. JF - Experimental Eye Research. SN - 0014-4835. IS - 3. ER - ...

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