Purpose: To assess the comparative antiemetic efficacy of single-dose intravenous (IV) dolasetron mesylate and ondansetron in preventing cisplatin-induced nausea and vomiting. Patients and Methods: Cancer patients (n = 609) receiving first-course cisplatin chemotherapy were randomized to one of three treatments: 1.8 or 2.4 mg/kg dolasetron mesylate salt (equivalent to 1.3 and 1.8 mg/kg dolasetron base, respectively) or 32 mg ondansetron. Each treatment was infused over 15 minutes, 30 minutes before cisplatin administration. Patients were stratified to cisplatin doses of ,greater than or equal to greater than or equal to 70 and less than 91 mg/m(2) (n = 368) or greater than or equal to 91 mg/m(2) (n = 241), administered over less than or equal to 3 hours, protocol-defined efficacy criteria included complete response (zero emetic episodes and no rescue medication), major response (1 to 2 emetic episodes and no rescue medication), and patients report of nausea severity and satisfaction recorded on ...

Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group.

TY - JOUR. T1 - Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists. AU - Lee, Ga Eun. AU - Lee, Ho Sung. AU - Lee, So Deok. AU - Kim, Jung Ho. AU - Kim, Won Ki. AU - Kim, Yong Chul. N1 - Funding Information: This study was supported by a grant of the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0720430) and by a research grant from the Korea Science and Engineering Foundation (R01-2006-000-10880-0). PY - 2009/2/1. Y1 - 2009/2/1. N2 - Iminium quaternary protoberberine alkaloids (QPA) have been found to be novel P2X7 antagonists. To assess their structure-activity relationships, these compounds were modified at their R1 and R2 groups and assayed for their ability to inhibit the 2′(3′)-O-(4-benzoylbenzoyl)-ATP (BzATP)-induced uptake of fluorescent ethidium by HEK-293 cells stably expressing the human P2X7 receptor, and their ability to inhibit BzATP-induced IL-1β release by ...

Recent research has shown that oxymatrine prevents cardiac fibrosis in rats.[8] The development of fibrotic tissue in the heart occurs when fibroblasts produce excessive amounts of collagen (particularly types I and III),[9] which accumulate and deposit in the heart. The excessive transformation to fibrotic tissue negatively affects the function and structure of the heart. Additionally, excessive amounts of collagen in the ventricles lead to alterations in gene expression, deposition of extracellular matrix, wall thickening, and ventricular remodeling in a manner that promotes dysfunction.[10] The mechanism by which oxymatrine may inhibit fibrosis is still unidentified. One theory that has been proposed is that oxymatrine inhibits a key signaling pathway involved in collagen production. One of the main signaling receptors involved in this pathway is the TGF-β1 co-receptor (complex of type I and type II receptors), which acts as a trans-membrane protein serine/threonine kinase.[11] A receptor ...

The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimers disease (AD). In this study, we found that matrine (Mat) could maintain or even enhance the cytotrophic effect of Aβ42 monomers by inhibiting their aggregation and by working in a manner similar to synergy with Aβ42 monomers. Moreover, Mat could also exert a cytoprotective effect by actively promoting the disaggregation of immature Aβ42 oligomers in a concentration-dependent manner. Although Mat at intermediate concentrations (1-50 μM) exhibited both cytotrophic and cytoprotective effects on SH-SY5Y cells, Mat at higher concentrations (100 μM) only exhibited a cytoprotective effect. Molecular docking studies reveal that these differences are a result of the different interactions between Mat and Aβ42 oligomers that occur at different molecular ratios. Our results support the hypothesis that there may be a Mat-like metabolite in the ...

Fengzu Biological is one of the professional China Matrine Powder manufacturers, for all you needs of best, price, organic, 100% pure, nature, and GMP factory Matrine Powder, please feel free to contact us. And welcome to wholesale bulk and high quantity Matrine Powder from us.

Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Dolasetron injection is used to prevent nausea and vomiting caused by surgery. Dolasetron injection may also be used for purposes not listed in this medication guide.

Oxymatrine suppresses MOVAS proliferation induced by platelet-derived growth factor via G0/G1 arrest, Heng Li, Ke Hu, Shan Gao, Danna Tu, Jinbing You, Xia Gao

Anzemet (dolasetron) is a small molecule pharmaceutical. Dolasetron was first approved as Anzemet on 1997-09-11. It is used to treat postoperative nausea and vomiting in the USA.

Dolasetron (trgovačko ime Anzemet) je serotonin 5-HT3 receptor antagonist[1] korišćen u tretmanu mučnine i povraćanja nakon hemoterapije. Njegov glavni efekat je smanjenje aktivnosti Vagus nerva, koji je nerv što aktivira centar za povraćanje u medulla oblongata. On nema primetan antiemetički efekt kad su simptomi uzrokovani morskom bolešću. Ovaj lek nema efekta na dopamin receptore, nit na muskarinske receptore. Dolasetron se sporo razlaže, i zadržava se u telu dogo vremena. Jedna doza obično traje 4 do 9 sati. On se normalno administrira jednom ili dva puta dnevno. Ovaj lek se odstranjuje is tela putem jetre i bubrega. ...

The OB-6® desktop module is just as powerful and easy to use as its counterpart, the OB-6 Keyboard. The module has all of the same controls as the keyboard version and provides the same immediacy and ease of use. As with the OB-6 Keyboard, all parameters are at your fingertips, with full-sized knobs and switches and a comfortable, intuitive layout.. How does it sound? Massive-just like the keyboard, because on the inside, its exactly the same. The same analog signal path with discrete VCOs and VCFs. The same high-quality digital effects. The same classic Oberheim sound that has been earning raves from musicians around the world.. Weve also added a poly chain feature so that any two OB-6s can be paired for twelve-voice polyphony!. ...

Yan Liu1,2*, Lei Qin2*, Tingting Bi1, Wei Dai1, Wei Liu1, Quangen Gao1✉, Genhai Shen1✉ 1. Department of General Surgery, Wujiang No.1 Peoples Hospital affiliated to Nantong University, Suzhou, Jiangsu 215200, PR ...

Buy Genetic Structure and Selection in Subdivided Populations (MPB-40) by Francois Rousset (9780691088174) from Boomerang Books, Australias Online Independent Bookstore

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...

Top ⭐ 26 reasons for Noontec Zoro Wireless vs Audio-Technica ATH-ES10 vs Status OB-1: 1. highest frequency 2. lowest frequency 3. weight 4. impedance 5. can be folded

reussir le Delf junior et scolaire B2 guide pédagogique- Guide contenant les corrigés des activités, des conseils de mise en place des a

TY - JOUR. T1 - Matrine Attenuates COX-2 and ICAM-1 Expressions in Human Lung Epithelial Cells and Prevents Acute Lung Injury in LPS-Induced Mice. AU - Liou, Chian Jiun. AU - Lai, You Rong. AU - Chen, Ya Ling. AU - Chang, Yi Hsien. AU - Li, Zih Ying. AU - Huang, Wen Chung. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Matrine is isolated from Sophora flavescens and shows anti-inflammatory effects in macrophages. Here we evaluated matrines suppressive effects on cyclooxygenase 2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1) expressions in lipopolysaccharide-(LPS-) stimulated human lung epithelial A549 cells. Additionally, BALB/c mice were given various matrine doses by intraperitoneal injection, and then lung injury was induced via intratracheal instillation of LPS. In LPS-stimulated A549 cells, matrine inhibited the productions of interleukin-8 (IL-8), monocyte chemotactic protein-1, and IL-6 and decreased COX-2 expression. Matrine treatment also decreased ICAM-1 protein expression and suppressed ...

Define cytisine. cytisine synonyms, cytisine pronunciation, cytisine translation, English dictionary definition of cytisine. n a toxic alkaloid found in several species of plants, similar in molecular structure to nicotine

Find Bitter Sophora Root Extract Matrine Version Manufacturers & Suppliers from China. We are Professional Manufacturer of Bitter Sophora Root Extract Matrine Version company, Factory & Exporters specialize in Bitter Sophora Root Extract Matrine Version wiht High-Quality.

Objective: To study the therapeutic efficacy of intraperitoneal perfusion of Compound Matrine injection and Cisplatin on malignant ascites. Methods: Forty- two patients of malignant ascites were randomly divided into treatment group and control group. 22 patients were treated with Compound Matrine injection and Cisplatin intraperitoneal perfusion( treatment group),and 20 patients were treated with Cisplatin intraperitoneal perfusion only( control group). The changes in volume of ascites and treatment side effects were observed. Results: The objective response rate( CR and PR) of treatment group and control group were 90. 9% and 65. 0% respectively,and the difference was significant( P 0. 05). The treatment group had a slighter side effect on abdominal pain,gastrointestinal rection and bone marrow depression,and the difference was significant( P 0. 05). Conclusion: The results suggest that intraperitoneal perfusion of Compound Matrine injection and Cisplatin is safe and effective in treating malignant

In this single-centre, randomised, double blind, placebo-controlled trial, the efficacy and safety of cytisine as an aid in smoking cessation was compared with placebo. Three hundred and seventy participants were randomly assigned to either the active drug or placebo in an equal ratio for 25 days. Participants in both groups received a minimal amount of counselling during the study.. The primary outcome measure was sustained biochemically-verified smoking abstinence for 12 months after the end of treatment. Secondary outcomes were sustained abstinence for the first 6 months and point prevalence at 12 months. This study found that the rate of sustained 12-month abstinence was 8.4% (31 participants) in the cytisine group compared with 2.4% (9 participants) in the placebo group. The 7-day point prevalence for abstinence at the 12-month follow-up was 13.2% in the cytisine group and 7.3% in the placebo group. The relative difference in smoking cessation between cytisine and placebo was higher than ...

Product Details of Fluorescent Brightener 393 CAS 1533-45-5 Fluorescent Brightener OB-1. FBA393. Optical Brightener OB-1, Fluorescent Brightener 393 CAS 1533-45-5 Fluorescent Brightener OB-1. FBA393. Optical Brightener OB-1 from China manufacturer on Hisupplier.com.

Cytisine: | | Cytisine | | | ||| | | |... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.

When combined with brief behavioral support, cytisine was found to be superior to nicotine-replacement therapy in helping smokers quit smoking, but it was associated with a higher frequency of self-reported adverse events. (Funded by the Health Research Council of New Zealand; Australian New Zealand …

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...

Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities in vitro and in vivo ...

Top ⭐ 25 reasons for Sennheiser Momentum Wireless vs AKG K99 Perception vs Status OB-1: 1. highest frequency 2. lowest frequency 3. impedance 4. sound pressure level

Provides information on toxicity, therapeutic range, clinical studies and usage details. Intended for the treatment of tobacco smoking. ...

Microwave-Assisted Extraction of Oxymatrine from Sophora flavescens. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Autophagy has been referred to as a double-edged sword in tumorigenesis and tumor progression. Emerging evidence suggests that pharmacological modulation of autophagy is a promising therapeutic strategy for cancer. However, few autophagy-modulating compounds are currently approved for clinical use in humans. Matrine is a natural compound extracted from traditional Chinese medicine that is widely used for treatment of a variety of diseases without any obvious side effects. Recently, matrine has been reported to induce autophagy and autophagic cell death in cancer cells, although the underlying mechanisms have yet to be elucidated. Here, we systematically examined the autophagic events induced by matrine in SGC7901 cells. The accumulation of autophagic vacuoles in matrine-treated cells was verified by the conversion of microtubule-associated protein light chain 3 as well as confocal and transmission electron microscopy. Furthermore, we demonstrated that matrine blocked autophagic degradation by ...

0051]Procedure: Field corn, Zeamx mays l. was seeded into 3.5×3.5 containers in a growing medium consisting of 35% peat, 45% aged pine bark, 15% aged rice hulls and 5% composted hardwood. One container equals one replicate. Test plants were placed in Zone 2 of research greenhouse on a wire-mesh raised bench and arranged in a randomized complete block design. Research greenhouse is monitored by Procom, Micro-Grow Greenhouse System temperature control system. Environmental conditions averaged high temperature 82 F to low temperature of 70 F during study dates. Average humidity levels ranged form 40% to 95%. Test plants received natural lighting for duration of study. Test plants were watered every twenty-four (24) hours as needed with a hand-held sprinkler. Corn plants were artificially infested with five (5) tobacco budworm, Heliothis virescent, 1st instar larva. Larva was placed in leaf rolls of each replicate. After infesting each replicate was placed on a drip plate for watering purposes. ...

To address the issue of binding selectivity among nAChR subtypes, we measured affinities of unlabeled 5-iodo-A-85380 in four different competition assays. To determine the affinity of 5-iodo-A-85380 for the α4β2 subtype, we used previously described competition assays with (±)-[3H]epibatidine or (-)-[3H]cytisine and P2 membrane fractions of Fischer-344 rat forebrain. Consistent with the previous observations (Koren et al., 1998), Scatchard plots of (±)-[3H]epibatidine binding to these rat brain membranes, at ligand concentrations of 1 to 800 pM, revealed a single population of binding sites (data not shown) with aK d of 9.5 ± 0.5 pM (n= 4). Similar high-affinity binding of (±)-[3H]epibatidine was observed in the rat (Houghtling et al., 1995), mouse (Marks et al., 1998), and human brain (Houghtling et al., 1995; Sihver et al., 1998), as well as in transfected cells stably expressing the α4β2 nAChR subtype (Houghtling et al., 1995; Whiteaker et al., 1998). In addition, the affinity of ...

Abnormal heart rhythms: Guanfacine can cause abnormal heart rhythms. Certain medications (e.g., sotalol, quinidine, chlorpromazine, pimozide, gatifloxacin, moxifloxacin, mefloquine, pentamidine, dolasetron mesylate, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with this medication. If you have been told that your child is at an increased risk of developing an abnormal heart rhythm, discuss with your doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.. Drowsiness and reduced alertness: Guanfacine may affect the mental or physical abilities needed to perform tasks that require special attention. Have your child avoid riding a bike, operating machinery, or performing other hazardous tasks until you have determined how this medication affects your child.. Kidney ...

Back, H., Song, B., Chae, J., Yun, H., Ma, J. and Kwon, K. (2015). Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK. Journal of Analytical Methods in Chemistry, 2015, pp.1-6 ...

Buy quality sophora flavescens extract products from sophora flavescens extract manufacturer, 390 sophora flavescens extract manufacturers & sophora flavescens extract suppliers from China.

Buy Pure Organic Foliar Spray Matrine Insecticide Biochemical Fertilizer Humus Plus Organic Fertilizer from Commercial Organic Fertilizer Manufacture，humus plus organic fertilizer Distributor online Service suppliers.

Buy Resource Competition and Community Structure. (MPB-17), Volume 17 by David Tilman (9780691083025) from Boomerang Books, Australias Online Independent Bookstore

The IUPHAR/BPS Guide to Pharmacology. [3H]epibatidine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.

The IUPHAR/BPS Guide to Pharmacology. [125I]epibatidine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities in vitro and in vivo ...

We Beijing Multigrass Formulation Co., Ltd. is a leading company in China which is specialized in organic insecticide, organic fungicide, Amino Acid and organic seaweed extract fertilizers manufacturing. With advanced extracting techniques, .....

BioAssay record AID 145519 submitted by ChEMBL: Nicotinic acetylcholine receptor binding activity was determined by ability to displace [3H]- (-) cytisine binding from whole rat brain synaptic membranes..

China Hot Sale 100% Natural Sophora Japonica Extract Powder 99% Cytisine, Find details about China Sophora Japonica Extract, Pharamceutial Chemical from Hot Sale 100% Natural Sophora Japonica Extract Powder 99% Cytisine - Suzhou Jiameiyuan Biotechnology Co., Ltd.

The lycopodium alkaloids are a large and extensively studied alkaloid family. Huperzine A (1), the medicinally most significant lycopodine alkaloid as a potential treatment for Alzheimers disease, functions as an acetylcholinesterase inhibitor but may have other roles as has been addressed in several recent reviews. Sauroine (2, 7,8-dihydroxylycopodine), from Huperzia saururus, was reported in 2004 and shown in 2009 to improve memory retention in the step-down test in male Wistar rats, significantly increasing hippocampal plasticity. 7-Hydroxylycopodine (3), from Huperzia serrata, was also reported in 2004 and may have related biological activity.. ...

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center.. Patients receive their scheduled chemotherapy regimen containing doxorubicin and their scheduled oral 5 hydroxytryptamine 3 receptor antagonist antiemetic (ondansetron, granisetron, tropisetron, or dolasetron mesylate) combined with dexamethasone on day 1.. Patients are then randomized to 1 of 3 antiemetic arms.. ...

Ioannides, C, Okine, L and Parke, DV (1979) Effects of β-adrenoceptor antagonists on the hepatic mixed-function oxygenases in the rat ...

2-a-week pill helps smokers quit habit(The Times p23) by Sam Lister, September 29 2011 12:01AM. A course of pills likely to cost less than £2 a week can help people to quit smoking as effectively as any other medication and at a tiny fraction of the price, a study has shown. Researchers said that using cytisine can triple a smokers chances of giving up. More significantly, it could become the first treatment that costs less than a packet of cigarettes.. The study, funded by the Medical Research Council and led by scientists at University College London, involved 740 patients who took cytisine or a placebo for four weeks. No other health counselling was offered.. Those on cytisine were 3.4 times more likely to succeed than those on the placebo. After a year, 8.4 per cent of participants had quit smoking, a similar rate to nicotine patches and gums.. The findings, published inThe New England Journal of Medicine, suggest that on a longer course and with counselling, cytisine will perform ...

BioAssay record AID 629811 submitted by ChEMBL: Displacement of [3H]epibatidine from alpha4beta2 nAChR in Sprague-Dawley rat cerebral cortex by beta counting.

(-)-Epibatidine dihydrochloride | Nicotinic agonist | Epibatidine | CAS [152378-30-8] | Axon 1078 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research

auxiliary data: Odanacatib-(MK0822).html src_compound_id: Odanacatib-(MK0822) - auxiliary data: AZD8330(ARRY-424704).html src_compound_id: AZD8330(ARRY-424704) - auxiliary data: alogliptin-syr-322.html src_compound_id: alogliptin-syr-322 - auxiliary data: Fleroxacin(Quinodis).html src_compound_id: Fleroxacin(Quinodis) - auxiliary data: Enalaprilat.html src_compound_id: Enalaprilat - auxiliary data: sasapyrine.html src_compound_id: sasapyrine - auxiliary data: gdc-0032.html src_compound_id: gdc-0032 - auxiliary data: Leucovorin-Calcium.html src_compound_id: Leucovorin-Calcium - auxiliary data: zidovudine-retrovir.html src_compound_id: zidovudine-retrovir - auxiliary data: Alfuzosin-hydrochloride.html src_compound_id: Alfuzosin-hydrochloride - auxiliary data: Triamcinolone(Aristocort).html src_compound_id: Triamcinolone(Aristocort) - auxiliary data: flumequine.html src_compound_id: flumequine - auxiliary data: gsk2126458.html src_compound_id: gsk2126458 - auxiliary data: VX-770.html ...

We showed that vinflunine previously, a microtubule-targeting medication of the and assays. produced with Metamorph software program?. Transwells HUVECs or U87 (50.000 per condition) were put on the upper side of a transwell migration chamber (0.8 m filter, BD) Matrine in serum free moderate. The smaller part of the holding chamber was stuffed with tradition moderate finished with VEGF (10 ng/ml) for migration of HUVECs or regular tradition moderate for U87 cells. Cells were allowed to transmigrate for 5 l and chambers were removed in that case. Cells PRPH2 that do not really migrate remained on the upper part of the filter and were removed with a cotton stick; cells on the lower side of the filter were fixed with 1% glutaraldehyde (Sigma- Aldrich) and stained with 1% Crystal-violet solution in 20% methanol. After washing and drying, pictures of four fields per filter were taken at a magnification of 10. Quantification of cell transmigration was made with Metamorph software Matrine ? and results ...

The spores of the Lycopodium plant, called Lycopodium powder, or, often, dragons breath, can be used in a variety of ways, including (but not limited t...

THE PROPOSAL IS TO CONDUCT RESEARCH ON POLYCULTURE OF OY- STERS IN PONDS WITH MARINE SHRIMPL SURVIVAL OF OYSTERS IN STATIC WATER PONDS IS LOW, BUT IT IS ANTICIPATED THE SURVI- VAL AND GROWTH WILL BE GOOD IN PONDS WHERE AERATION DEVICES CAUSE WATER TO CIRCULATE WITHIN THE POND. BESIDES THE OB- VIOUS ECONOMIC BENEFIT TO BE DERIVED FROM THE SALE OF OY- STERS, BENEFITS TO GENERAL POND PRODUCTIVITY ARE .... ...

Revision as of 08:17, 31 January 2011 by Tsukasa (Talk , contribs) (Created page with ==Introduction== Limited series are released by Luts irregularly. Zuzus come as full sets in different resin colors and with different accessories based on their characters. =…) ...

Climate change is causing wildfires to burn more fiercely, pumping more greenhouse gases into the atmosphere than previously thought, according to a new study to be published in Nature Geoscience this week.