Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give final compounds. All of these compounds were screened for their in vitro antimicrobial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
WILHELM, ETHEL A. et al. Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive. An. Acad. Bras. Ciênc. [online]. 2017, vol.89, n.1, suppl., pp.457-467. Epub May 22, 2017. ISSN 0001-3765. https://doi.org/10.1590/0001-3765201720160668.. The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a toxicological parameter. A second objective of this study was to evaluate the in vivo antinociceptive effect of the compound with better antioxidant effect and without toxic effects in a model of nociception induced by formalin in mice. In liver, at 100 µM, compound a reduced the lipid peroxidation to the control ...
TY - JOUR. T1 - Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain. AU - Son, Myung Hee. AU - Kim, Ji Young. AU - Lim, Eun Jeong. AU - Baek, Du Jong. AU - Choi, Kihang. AU - Lee, Jae Kyun. AU - Pae, Ae Nim. AU - Min, Sun Joon. AU - Cho, Yong Seo. PY - 2013/3/1. Y1 - 2013/3/1. N2 - We described here the synthesis and biological evaluation of mGluR5 antagonists containing a quinoline ring structure. Using intracellular calcium mobilization assay (FDSS assay), we identified compound 5n, showing high inhibitory activity against mGluR5. In addition, it was found that compound 5n has excellent stability profile. Finally, this compound exhibited favorable analgesic effects in spinal nerve ligation model of neuropathic pain, which is comparable to gabapentin.. AB - We described here the synthesis and biological evaluation of mGluR5 antagonists containing a quinoline ring structure. Using intracellular calcium ...
Read "Iodine-catalyzed synthesis of pyrazolo[4,3-f]quinoline derivatives via a highly regio-selective Povarov reaction, Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
A library of 1,2,4-oxadiazole functionalized quinoline derivatives ( 13a-j) were synthesized and their structures were confirmed by 1H NMR, 13CNMR and Mass Spectral analysis. Further, these compounds...
Granik, V.G., Pechenina, V.M., Mukhina, N.A. et al. Synthesis of imidazo [4,5-f]- and [5,4-g]quinoline derivatives. Pharm Chem J 23, 484-487 (1989). https://doi.org/10.1007/BF01145804. Download ...
4. The compound according to claim 1 selected from the group consisting of6-(4-Methoxy-benzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-indolo[2,3-c]quino- lin-1-one;6-(4-Methoxy-benzyl)-2,3,4,7-tetrahydro-indolo[2,3-c]quinolin-1-- one;6-Benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinolin-1-one;6-(4-Methoxy-b- enzyl)-3-methyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline;6-(4-Bromo-be- nzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinolin-1-one;6-(4-Met- hoxy-benzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline;6-Benzo[1,3]diox- ol-5-ylmethyl-3,3-dimethyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinolin-1-one;- 6-(4-Bromo-benzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline;6-(3-Metho- xy-benzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinolin-1-one;3,3- -Dimethyl-6-(4-trifluoromethoxy-benzyl)-2,3,4,7-tetrahydro-indolo[2,3-c]qu- inolin-1-one;6-(4-Ethoxy-benzyl)-3,3-dimethyl-2,3,4,7-tetrahydro-indolo[2,- 3-c]quinolin-1-one;3,3-Dimethyl-6-(3-nitro-benzyl)-2,3,4,7-tetrahydro-indo- ...
The synthesis and anti-cancer activity evaluation of fused imidazoquinoline compounds is reported in this paper. Yb(OTf)3 has been utilized as a catalyst for the synthesis of 1,4-diaryl substituted imidazo[4,5-c]quinolines via a modified Pictet-Spengler approach. The desired imidazole ring was synthesized from imines using TosMIC (toluenesulfonylmethyl isocyanide) and subsequently functionalized at the C-4 position yielding an imidazoquinoline skeleton. Importantly, the final step was carried out without the aid of any prefunctionalization to obtain the resultant compounds in good yields. The synthesized compounds, when screened for anti-cancer activity, revealed the highest activity with 4-(2-bromophenyl)-1-phenyl-1H-imidazo[4,5-c]quinoline (IC50: 103.3 μM).
2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol 150026-75-8 NMR spectrum, 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol H-NMR spectral analysis, 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol C-NMR spectral analysis ect.
Dysregulation of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling has been found in several types of human cancer, including hepatocellular carcinoma (HCC). NVP-BEZ235 is a novel, orally bioavailable dual PI3K/mTOR inhibitor that has exhibited promising activity against HCC in preclinical models. Autophagy is a cellular lysosomal degradation pathway essential for the regulation of cell survival and death to maintain homeostasis. This process is negatively regulated by mTOR signaling and often counteracts the efficacy of certain cancer therapeutic agents. In this study, we explored the role of autophagy in apoptosis induced by NVP-BEZ235 in two HCC cell lines, Hep3B and PLC/PRF/5, and identified the mechanism of combinatorial treatment. NVP-BEZ235 was effective in inhibiting the growth of the two HCC cell lines possibly though induction of apoptosis. NVP-BEZ235 also potently increased the expression of LC3-II and decreased the expression of p62, indicating ...
Synthesis of 7**H**-indolo[2,3-c]quinolines: study of the Pd-catalyzed intramolecular arylation of 3-(2-bromophenylamino)quinolines under microwave irradiation ...
Read about the chemical and physical properties of 2-nitro-3-methylimidazo(4,5-f)quinoline. Get 2-nitro-3-methylimidazo(4,5-f)quinoline molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
n-BuLi 1.6M (0.0048 mol) was added at -70°C to a mixture of N-(l -methylethyl)-2-propanamine (0.0049 mol) in THF (15 ml). The mixture was stirred at -20°C for 20 minutes. A solution of intermediate 6 (prepared according to A4.b) (0.004 mol) in THF (5 ml) was added at -70°C. The mixture was stirred at -70°C for 2 hours. A solution of intermediate 4 (prepared according to A3) (0.004 mol) in THF (5ml) was added at -70°C. The mixture was stirred at -70°C for 3 hours. NttjCl 10% was added. The mixture was extracted with EtOAc. The organic layer was separated, dried (MgSO.0, filtered, and the solvent was evaporated. Yield: 2.1 g. This fraction was purified by column chromatography over silica gel (eluent: CHjCla/CHaOH/NHiOH 96.5/3.5/0.1; 15-40nm). Two fractions were collected and the solvent was evaporated. Yield: 0.123 g of fraction A and 0.122g of fraction B. Fraction A was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 98/2; 15-40M.m). The pure fractions were ...
1H-imidazo[4,5-c]quinoline which are bronchodilators. Pharmacological methods of using the compounds as bronchodilators, pharmaceutical compositions containing the compounds, and synthetic intermediat
Where to buy 8-Hydroxy Quinoline Potassium Hydrogen Sulfate? 8-Hydroxy Quinoline Potassium Hydrogen Sulfate Suppliers,8-Hydroxy Quinoline Potassium Hydrogen Sulfate Prices on Green Stone - medicinerawmaterials.com.
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View Notes - reaction_review from CHEM 20 at Harvard. ALKENES Br H2 (D2) Lindlars cat Pd / C / quinoline syn addition Na/NH3 gives trans where applicable K+ O In general, E1 and E2 (for other
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
4,7-Dichloro-1,3-dimethyl-1H-pyrazolo[3,4-b]quinoline | C12H9Cl2N3 | CID 622215 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
7-(2,3-Dihydroxy-3-methylbutoxy)-4-methoxyfuro[2,3-b]quinoline | C17H19NO5 | CID 177139 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for ACENAPHTHO[1,2-B]QUINOLINE (CAS No. 207-09-0)
The current study indicates that administration of the dual ABCB1 and ABCG2 inhibitor tariquidar results in a statistically significantly increase in plasma, liver and brain exposure to imatinib. Since imatinib is known to have very high bioavailability (approximately 98%) [1], it is likely that the difference in plasma AUC is due to modified distribution and/or elimination of the drug, rather than a change in the extent of intestinal absorption. This hypothesis is supported by the fact that tariquidar increased the peak plasma concentration of imatinib by less than 20% and this change was not statistically significant. As expected, there was also no apparent change in the rate of absorption. Considering that imatinib is effluxed by both ABCB1 and ABCG2, the almost complete bioavailability may seem somewhat surprising. However, it is possible that the high concentrations of imatinib in the gut are actually leading to localized inhibition of these transporters, as has been suggested by inhibition ...
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Structure, properties, spectra, suppliers and links for: trans-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol.
You are viewing an interactive 3D depiction of the molecule (2s)-1-amino-3-[(5-nitro-8-quinolinyl)amino]-2-propanol (C12H15N4O3) from the PQR.
4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID chemical properties, What are the chemical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID 35957-14-3, What are the physical properties of 4-HYDROXY-BENZO[H]QUINOLINE-3-CARBOXYLIC ACID ect.
1-(5,8-dimethoxy-2,4-dimethyl-3-quinolinyl)ethanone - chemical structural formula, chemical names, chemical properties, synthesis references
CAS NO:22934-41-4; Chemical name:Quinoline-5-carbaldehyde ; physical and chemical property of 22934-41-4, Quinoline-5-carbaldehyde is provided by ChemNet.com
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PART I. A deuterium exchange analysis of 2,5-dihydroxyacetanilide (5) in the absence and presence of DHAE II was performed to test the nucleophilicity of the substrate in the absence and presence of catalyst. In addition, inhibition studies using 1,4-dihydroxybenzene were performed to determine the role that the N-acetyl side chain group plays in the formation of a stable substrate-enzyme complex. 1,4-Dihydroxybenzene was found to be a weak inhibitor, indicating that the N-acetyl functionality may play a crucial role in forming stable enzyme-substrate interactions. The synthesis of dihydroquinoline 7 was pursued to investigate the enzyme substrate interactions between DHAE and a substrate where the N-acetyl side chain has been fixed to a particular orientation. Efforts towards formation of the C6-C7 bond as a key step in the synthesis of dihydroquinoline 7 using palladium couplings, organocuprates, Lewis acid catalysts, and aza-Claisen reactions were pursued. To complement the results obtained, ...
3-Amino-4-cyanopyrazole I reacts with hydroxylamine and with hydrazine to yield 1H,6H-3-aminopyrazolo[3,4-c]pyrazole (III and IV). Diazotized IV couples with 2-naphthol to give the arylazo derivative VI which cyclizes to 9H-naphthol[2,1-e]pyrazolo[3,4:3,4]pyrazolo[5,1-c]-[1,2,4]triazine VII by means of acetic acid. The pyrazol-5-ylthiourea obtained from I and phenyl isothiocyanate undergoes base-catalyzed cyclization to give pyrazolo[3,4-d]pyrimidinethione derivative IX. Compound I reacts with cyclohexane in the presence of zinc chloride to give the tetrahydropyrazolo[3,4-b]quinoline derivative XI. The reaction of I with pyridine 1-oxide affords 4H,5H-pyrazolo[5,1:2,3] [1,2,4]triazolo[1,5-a]pyridine-3-carbonitrile XII.. ...
In the title compound, C16H10ClNO2, the dihedral angle between the quinoline ring system and the benzene ring is 14.7 (5)°. The carboxylate group is twisted from the mean planes of the quinoline ring system and the benzene ring by 17.7 (5) and 32.1 (4)°, respectively. In the crystal, inversion dimers are formed with the molecules linked by pairs of weak C-H�O interactions arising from an activated aromatic C atom adjacent to the C-Cl bond, generating R 22(14) loops.. ...
Read about the chemical and physical properties of 4-[(E)-2-[(2-fluorophenyl)methylidene]hydrazin-1-yl]-2-methyl-6-(trifluoromethyl)quinoline. Get 4-[(E)-2-[(2-fluorophenyl)methylidene]hydrazin-1-yl]-2-methyl-6-(trifluoromethyl)quinoline molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
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QUINOLINE-5-CARBONYL AZIDE,CCD编号:CCD03496255,分子式:C10 H6 N4 O,分子量:198.184,同义词:QUINOLINE-5-CARBONYL AZIDE; 分子结构,化学云数据库
QUINOLINE-2,3-DIOL,CCD编号:CCD00133569,分子式:C9 H7 N O2,分子量:161.159,同义词:QUINOLINE-2,3-DIOL; 2,3-QUINOLINEDIOL; 2,3-DIHYDROXYQUINOLINE; 分子结构,化学云数据库
This study is evaluating the safety of Dihydroartemisinin-Piperaquine for the use in mass treatment campaigns to block malaria transmission.
Montelukast Racemate (Acid),Montelukast Acid Racemate ; 1-[[[(1RS)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid ;
Moxifloxacin Decarboxy Analog ;. Decarboxy Moxifloxacin HCl ;. 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline HCl ;. CAS # 1322062-57-6 (base) ;. C20H24FN3O2 (base) ; MW: 357.42 ;. C20H25ClFN3O2 (HCl salt) ; MW: 393.88 ;. Supplied as HCl salt ;. ...
The main goal of this study is to determine how taking efavirenz affects the levels of pitavastatin in the bloodstream when both drugs are taken together and to see how darunavir with ritonavir affects the levels of pitavastatin in the bloodstream. Secondary goals are to see how taking pitavastatin affects the levels in the blood of efavirenz when both drugs are taken together and to see how taking pitavastatin affects the levels in the blood of darunavir ...
The main goal of this study is to determine how taking efavirenz affects the levels of pitavastatin in the bloodstream when both drugs are taken together and to see how darunavir with ritonavir affects the levels of pitavastatin in the bloodstream. Secondary goals are to see how taking pitavastatin affects the levels in the blood of efavirenz when both drugs are taken together and to see how taking pitavastatin affects the levels in the blood of darunavir ...
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91-22-5 Quinoline testing. Laboratory testing for CAS number 91-22-5. B 500;Benzopyridine;Benzo[b]Pyridine;Leucol;Leukol;Quinolin;1-Azanaphthalene;1-Benzazine;1-Benzine;Chinoline;Chinoleine;Chinolin;Leucoline;USAF ek-218;UN 2656. This chemical is colourless to brown liquid