Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is an enzyme that in humans is encoded by the ENPP1 gene. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5 triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with Idiopathic infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been shown to interact with Insulin receptor. GRCh38: Ensembl release 89: ...
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2), is an enzyme that in humans is encoded by the ENPP2 gene. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme important for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lysophospholipase D activity that converts lysophosphatidylcholine into LPA. Autotaxin was originally identified as a tumor cell-motility-stimulating factor; later it was shown to be LPA (which signals through lysophospholipid receptors), the lipid product of the reaction catalyzed by autotaxin, which is responsible for its effects on cell-proliferation. The protein encoded by this gene functions as a phosphodiesterase. Autotaxin is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants have been identified. Autotaxin is able to cleave the phosphodiester bond between ...
The enzyme nucleoside triphosphate pyrophosphohydrolase (NTPPPH) is present in all joint fluids and on intraarticular cells. It… Expand ...
OBJECTIVE-A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K→Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or another variant in linkage disequilibrium with it. RESEARCH DESIGN AND METHODS-We characterized the haplotype structure of ENPP1 and selected 39 tag SNPs that captured 96% of common variation in the region (minor allele frequency ≥5%) with an r2 value ≥0.80. We genotyped the SNPs in 2,511 Framingham Heart Study participants and used age- and sex-adjusted linear mixed effects (LME) models to test for association with quantitative metabolic traits. We also examined whether interaction between K121Q and BMI affected glycemic trait levels. RESULTS-The Q allele of K121Q (rs1044498) was ...
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder that is frequently fatal in infancy. This disorder is characterized by calcification of large and medium sized arteries and myointimal proliferation resulting in arterial stenosis. In some affected individuals the disease is detected prenatally. Most patients die in early infancy due to myocardial infarction or congestive heart failure. GACI1 (MIM 208000) is caused by loss of function mutations in the ectonucleotide pyrophosphatase / phosphodiesterase 1 gene (ENPP1) and GACI2 (MIM 614473) is caused by loss of function mutations in the ATP-binding cassette, subfamily c, member 6 gene (ABCC6). ENPP1 is a transmembrane glycoprotein involved in the regulation of soft issue calcification and bone and joint cartilage mineralization via the generation of pyrophosphate (PPi). PPi is a physiological inhibitor of hydroxyapatite formation and a suppressor of chondrogenesis. ABCC6 is an ATP-binding cassette transmembrane ...
ENPP1 antibody [N2C2], Internal (ectonucleotide pyrophosphatase/phosphodiesterase 1) for WB. Anti-ENPP1 pAb (GTX103447) is tested in Human samples. 100% Ab-Assurance.
An ecto-nucleotide pyrophosphatase modulates purineceptor-mediated signal transduction and is inhibited by purinereceptor antagonists ...
In 2005 Seki et. al, used a candidate gene case-control association study of Japanese individuals with symptomatic disc disease (N=467) and controls (N=654) [PMID 2598035]. The intervertebral disc contains abundant extracellular matrix proteins that play crucial roles in homeostasis. The researchers selected 30 sequences variations in 20 such genes that encode matrix proteins in intervertebral disc. rs2073711 showed significant association with LDD ((OR 1.61, [CI 1.31 -1.98], p = 0.00020) [PMID 15864306]. The rs2073711 SNP (1184T→C ) is located in exon 8 of the cartilage intermediate layer protein gene (CILP), which is expressed abundantly in intervertebral discs, and was reported to have increased expression when degeneration occurs [PMID 15864306]. For the rs2073711 SNP, the ancestral allele is T and the disease associated risk allele is C. The allelic change results in a substitution of amino acid Ile395Thr. CILP proteins interact directly with TGF- β1 mediated extracellular matrix protein ...
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NG0224 is orthologously related to CAB84133 Neisseria meningitidis, strain Z2491, a putative nucleoside triphosphate pyrophosphohydrolase protein: residues 1-152 are 94% similar to residues 1-152 of NG0224. NG0224 is orthologously related to AAF4106 Neisseria meningitidis, strain MC58, a dATP pyrophosphohydrolase protein: residues 1-152 are 94% similar to residues 1-152 of NG0224 ...
Recombinant protein of human inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1, 20 ug available for purchase from OriGene - Your Gene Company.
Clone FR3-16A11 recognizes CD203c, a glycosylated type II transmembrane molecule that belongs to the family of ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP3) enzymes. Among hematopoietic cells, expression of CD203c is restricted to basophils as well as to mast cells and their precursors, and has been described as specific for this lineage. Protein and/or mRNA expression of CD203c has also been found in solid tissues such as uterus or prostate. Basophils and mast cells are key producers of mediators that drive the onset of inflammatory responses, e.g., in allergy. Allergen challenge leads to a rapid up-regulation of activation markers such as CD203c or CD63. Due to its restricted expression pattern, CD203c is discussed as a specific marker to monitor the allergen-induced activation of basophils, e.g., in flow cytometric basophil activation tests of the peripheral blood. - Great Britain
Clone FR3-16A11 recognizes CD203c, a glycosylated type II transmembrane molecule that belongs to the family of ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP3) enzymes. Among hematopoietic cells, expression of CD203c is restricted to basophils as well as to mast cells and their precursors, and has been described as specific for this lineage. Protein and/or mRNA expression of CD203c has also been found in solid tissues such as uterus or prostate. Basophils and mast cells are key producers of mediators that drive the onset of inflammatory responses, e.g., in allergy. Allergen challenge leads to a rapid up-regulation of activation markers such as CD203c or CD63. Due to its restricted expression pattern, CD203c is discussed as a specific marker to monitor the allergen-induced activation of basophils, e.g., in flow cytometric basophil activation tests of the peripheral blood. - Lëtzebuerg
Bone has emerged as an important endocrine regulator that can mediate the interplay between bone remodelling and energy metabolism. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) is a factor that regulates bone mineralisation and is elevated in individuals with insulin resistance, a condition associated with type 2 and obesity-related diabetes. Thus, this factor might play a role in the development of metabolic disease. Vicky MacRae and colleagues sought to investigate this by using Enpp−/− mice, which lack NPP1 and exhibit impaired bone metabolism. These mice showed a pronounced resistance to obesity and to the development of insulin resistance in response to chronic high-fat feeding. Moreover, Enpp1−/− mice exhibited increased levels of the bone-derived hormone osteocalcin, which increases β-cell proliferation and insulin secretion, thereby linking bone remodelling to metabolic homeostasis. These results support the involvement of NPP1 in the development of obesity and type ...
The first step to producing our specially designed enzymes was to change the wild-type gene that codes for Kumamolisin to code instead for variant enzymes with our desired amino acid substitutions. To do this, we designed mutagenic oligonucleotide primers that would anneal to the wild-type Kumamolisin gene and incorporate point mutations that, when expressed, would result in a variant of Kumamolisin with the desired amino acid shift. We isolated the single stranded DNA (ssDNA) of the sense strand of our gene by growing the vector harboring our gene in a uracil-N-glycosidase (UNG) and deoxyuracil triphosphate pyrophosphatase (DUT) deficient E. coli- strain. These cells thus did not have the ability to maintain thymine in their DNA, and so all Ts become replaced by Us in the DNA of these cells. We then harvested the ssDNA of the sense strand by infecting the cells with a bacteriophage that packages its own ssDNA genome, identified by length, and so in tandem also packaged our vector in single ...
Accepted name: FAD diphosphatase. Reaction: FAD + H2O = AMP + FMN. For diagram of reaction click here.. Other name(s): FAD pyrophosphatase; riboflavin adenine dinucleotide pyrophosphatase; flavin adenine dinucleotide pyrophosphatase; riboflavine adenine dinucleotide pyrophosphatase; flavine adenine dinucleotide pyrophosphatase. Systematic name: FAD nucleotidohydrolase. Comments: The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37289-30-8. References: 1. Ravindranath, S.D. and Appaji Rao, N. Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus. Arch. Biochem. Biophys. 133 (1969) 54-59. [PMID: 5810832]. 2. Shin, H.J. and Mego, J.L. A rat liver lysosomal membrane flavin-adenine dinucleotide ...
The CD203c molecule is a type II transmembrane protein that belongs to the ectonucleotide pyrophosphatase / phosphosdiesterase 3 (E-NPP3) family of enzymes involved in hydrolysis of oligonucleotides, nucleoside phosphates, and NAD.
May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956 ...
Three mutants, F80A, Y166A, and Y142A, were selected on the basis of their proximity to a hydrophobic tail in all substrates (Table 6). These mutants showed opposing patterns of relative impact on SM relative to the remaining three substrates. The Y142A mutant showed only half the activity of the WT enzyme against SM, but showed similar or better activity against PAF, LPC and pNPPC (Tables 1, 2, 3, and 4). The F80A and Y166A mutants showed reduced activity against LPC, PAF and pNPPC, but showed similar or better activity against SM (Tables 1, 2, 3, and 4). This pattern of activity differences was not predicted by the initial model complexes of these substrates. However, the hydrophobic tails of the endogenous substrates had been placed manually, and exploration of alternate tail positions had been limited. Molecular dynamics simulations of LPC 16:0 and SM were therefore used to allow the substrate tails to explore nearby low-energy placements within the enzyme for a representative substrate from ...
Accepted name: dCTP diphosphatase. Reaction: dCTP + H2O = dCMP + diphosphate. Other name(s): deoxycytidine-triphosphatase; dCTPase; dCTP pyrophosphatase; deoxycytidine triphosphatase; deoxy-CTPase; dCTPase. Systematic name: dCTP nucleotidohydrolase. Comments: Also hydrolyses dCDP to dCMP and phosphate.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9024-87-7. References: 1. Zimmerman, S.B. and Kornberg, A. Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli. J. Biol. Chem. 236 (1961) 1480-1486.. ...
Current evidence with respect to the role of other TRP channels in the endosomal pathway is less compelling than for TRPMLs. Still, several members from various TRP subfamilies are good candidates for future study given both their presence and/or association with endosomal membranes as well as recent findings on their physiological roles within these compartments.. Along with members of the TRPML subfamily, the TRPM2 channel is the only other known TRP channel that is found in late endosomes and lysosomes in mammals (47). TRPM2 is a chanzyme, meaning that it is a cation channel fused with an enzymatic ADP-ribose pyrophosphatase domain. TRPM2 is nonselective for cations, is permeable to Ca2+, and has a dual function both at the plasma membrane and at lysosomes (47). At the cell surface, TRPM2 operates as a Ca2+-influx channel allowing entry of Ca2+ inside the cell and the regulation of numerous biological effects including insulin secretion, detection of oxidative stress and apoptosis, increased ...
The ability of cells to detect and respond to nucleotide signals in the local microenvironment is essential for vascular homeostasis. The enzyme ectonucleotide tri(di)phosphohydrolase-1 (ENTPD1, also known as CD39) on the surface of leukocytes and endothelial cells metabolizes locally released, intravascular ATP and ADP, thereby eliminating these prothrombotic and proinflammatory stimuli. Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprotein E-deficient (ApoE-deficient) mouse model of atherosclerosis. Compared with control ApoE-deficient animals, plaque burden was markedly increased along with circulating markers of platelet activation in ...
1PUQ: Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
1PUS: Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells ...
Complete information for NUDT3 gene (Protein Coding), Nudix Hydrolase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
2010 05 09.49510 16 02 32.319 +00 26 09.90 21.6G 523713 F51 C~2kQ9 2010 05 11.55939 16 02 21.787 +00 27 10.99 21.7G 523713 F51 C~2kQ9 2010 06 04.37125 16 00 17.562 +00 35 55.78 21.2G 523713 F51 C~2kQ9 2010 07 30.25674 15 56 56.215 +00 32 00.64 21.5G 523713 F51 C~2kQ9 2011 04 30.53662 16 11 13.046 +00 40 04.81 21.2G 523713 F51 C~2kQ9 2011 04 30.53721 16 11 13.027 +00 40 04.99 21.5G 523713 F51 C~2kQ9 2011 05 11.45580 16 10 19.732 +00 45 55.88 20.8G 523713 F51 C~2kQ9 2011 05 11.46786 16 10 19.659 +00 45 56.62 21.9G 523713 F51 C~2kQ9 2012 05 16.47132 16 17 46.315 +01 07 29.79 21.5G 523713 F51 C~2kQ9 2012 05 16.48549 16 17 46.236 +01 07 30.20 21.9G 523713 F51 C~2kQ9 2012 05 16.49963 16 17 46.159 +01 07 30.59 21.8G 523713 F51 C~2kQ9 2012 06 15.38824 16 15 10.670 +01 15 45.53 21.7G 523713 F51 C~2kQ9 2012 06 15.40187 16 15 10.610 +01 15 45.54 21.8G 523713 F51 C~2kQ9 2012 06 15.41549 16 15 10.542 +01 15 45.80 21.3G 523713 F51 C~2kQ9 2012 06 15.42921 16 15 10.463 +01 15 45.77 21.4G 523713 F51 C~2kQ9 2013 ...
Purified Recombinant Human CILP protein, T7/His-tagged from Creative Biomart. Recombinant Human CILP protein, T7/His-tagged can be used for research.
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10722730). Can also hydrolyze other nucleotide sugars with low activity (PubMed:10722730). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate (By similarity). Nuclear ATP synthesis takes place when dephosphorylated at Thr-44 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968 ...
Complete information for NUDT11 gene (Protein Coding), Nudix Hydrolase 11, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
RPRDs NT (NUDT15, TPMT) and CNT (CEP72, NUDT15, TPMT) panels investigate all clinically relevant genetic variants in these PGx genes. Rapid TAT 3-5 days.
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Kit Component:- KN311321G1, Nudt16 gRNA vector 1 in pCas-Guide vector- KN311321G2, Nudt16 gRNA vector 2 in pCas-Guide vector- KN311321D, donor vector…
Kit Component:- KN311330G1, Nudt4 gRNA vector 1 in pCas-Guide vector- KN311330G2, Nudt4 gRNA vector 2 in pCas-Guide vector- KN311330D, donor vector…
Whenever Dr. Jennifer Coates is asked by a potential new dog owner which breed she would recommend for their family, the mutt appears somewhere on the list. She tells us why she prefers mutts in todays Fully Vetted.
ENPP7兔多克隆抗体(ab121827)可与人样本反应并经IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
NUDT18兔多克隆抗体(ab82997)可与人样本反应并经WB, ELISA实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
V35T, T39A, E44ED, V60I, K101KQ, V118VI, K122E, I135T, S162SDGN, H208HY, R211RK, K223KQ, V245VE, A272P, K277R, T286A, E297A, M357K, I375V, A400T, V435E, D460N, R461K, T470A, L491S, Q524E, Q547R, ...
不動産担保ローンは無担保のローンに比べ金利が安い - 所有している不動産を担保にして借り入れをする不動産担保ローンは 無担保のローンに比べると 不動産の価値にもよりますが 金利が安く 融資額が大きい 長期の借り入れが可能などのメリットがあります》 融資額の内容は所有している […] ...
They just wanted to make sure you were using a very comfy sofa..so when guests come you wouldnt be embarassed..they were halpin Mom ...
Results: SAM domain and HD domain-containing protein 1 (SAMHD1), an innate immune factor that suppresses HIV replication, was identified and confirmed as highly expressed in immune complexes from 16 hereditary and idiopathic PAH versus 12 control lungs. Elevated SAMHD1 was localized to endothelial cells, perivascular dendritic cells, and macrophages, and SAMHD1 antibodies were prevalent in tertiary lymphoid tissue. An unbiased screen using metagenomic sequencing related SAMHD1 to increased expression of human endogenous retrovirus K (HERV-K) in PAH versus control lungs (n=4). HERV-K envelope and deoxyuridine triphosphate nucleotidohydrolase mRNAs were elevated in PAH versus control lungs (n=10), and proteins were localized to macrophages. HERV-K deoxyuridine triphosphate nucleotidohydrolase induced SAMHD1 and proinflammatory cytokines (eg, interleukin 6, interleukin 1β, and tumor necrosis factor α) in circulating monocytes, pulmonary arterial endothelial cells, and also activated B cells. ...
Excellgen E. coli Inorganic Pyrophosphatase [EG-203] - Description Inorganic Pyrophosphatase catalyzes the hydrolysis of inorganic pyrophosphate into two orthophosphates. The enzyme requires a divalent metal cation with Mg2+ for activity Applications High yield RNA synthesis by in vitro transcription DNA polymerization reactions: preventing accumulation of pyrophosphate Removal of contaminant PPi in reagents used for SNP genotyping by methods based on the detection
Sigma-Aldrich offers abstracts and full-text articles by [Marcelo L Santoro, Tais S Vaquero, Adriana F Paes Leme, Solange M T Serrano].
Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1; MIM 241520) is caused by mutations in the dentin matrix acidic phosphoprotein 1 gene (DMP1) and hypophosphatemic rickets, autosomal recessive, 2 (ARHR2; MIM 613312) is caused by mutations in the ectonucleotide pyrophosphatase / phosphodiesterase 1 gene (ENPP1). DMP1 is a highly acidic, serine rich protein critical for osteocyte maturation. Several loss of function mutations have been described in DMP1. ENPP1 is a transmembrane glycoprotein regulating soft tissue calcification and bone and joint cartilage mineralization via generation of pyrophosphate (PPi). PPi is a physiological inhibitor of hydroxyapatite crystal formation and a suppressor of chondrogenesis. Loss of function mutations have also been described in ENPP1. Mutations in ENPP1 also cause generalized arterial calcification of infancy 1 (GACI1; MIM 208000). In at least one instance, the identical homozygous ENPP1 mutation has been shown to cause hypophosphatemic rickets in a ...
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Type 2 diabetes mellitus is a chronic disease characterised by progressive insulin resistance and loss of β-cell function. An incomplete understanding of its pathogenesis is hindering the effective treatment of this disease. Roux-en Y gastric bypass surgery (RYGB); however, causes rapid remission of liver insulin resistance and type 2 diabetes, and therefore affords us an opportunity to examine some fundamental characteristics of these conditions. Gathering evidence suggests that liver insulin resistance may be a crucial contributor to development of diabetes. In this thesis, we used liver biopsies taken before, and in some individuals after, RYGB surgery to explore or identify several molecular processes involved in the pathogenesis of type 2 diabetes. The study cohort included individuals with normal glucose tolerance and others with type 2 diabetes. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) may cause insulin resistance through its inhibitory action on insulin signalling. ...
This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase I / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulphate bonds in NAD, deoxynucleotides and nucleotide sugars [(PUBMED:9344668)]. Another member of this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity [(PUBMED:7982964)]. The alignment encompasses the active site [(PUBMED:7730366), (PUBMED:7982964)]. Also present within this family is 60 kDa Ca2+-ATPase from Myroides odoratus [(PUBMED:8617788)].. This signature also hits a number of ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.. ...