For advanced progressive primary IgA nephropathy (IgAN) no established therapy exists. We conducted a prospective trial to evaluate the effect of intravenous cyclophosphamide pulse therapy (CyP) on the course of advanced progressive IgAN. 21 patients (mean age 52 ± 10 years; male/female, 20/1) with biopsy-proven IgAN without crescentic extracapillary proliferation and serum creatinine more than 2.0 mg/dl and/or an increase more than 25 % in the previous 3 months were included. Patients were treated with CyP (750 mg/m2 body surface area) every 4 weeks for 6 months and low dose oral prednisolone. Renal function improved 12.5 % overall per year after therapy in linear regression analysis (p , 0.001). An increase , 25 % of serum creatinine before CyP 1 was observed in 8 patients after 0.7 years (range, 0.3 to 3.0 years), and three patients of these developed end-stage renal disease after 1.2 years (range, 0.7 to 2.8 years). Proteinuria decreased significantly after CyP therapy. A low nadir of white ...
TY - JOUR. T1 - Insight on mechanism of hyponatraemia induced by low-dose intravenous pulse cyclophosphamide. AU - Park, Se Jin. AU - Kim, Ji Hong. AU - Shin, Jae Il. PY - 2010/10/1. Y1 - 2010/10/1. UR - http://www.scopus.com/inward/record.url?scp=77957241620&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=77957241620&partnerID=8YFLogxK. U2 - 10.1093/ndt/gfq429. DO - 10.1093/ndt/gfq429. M3 - Letter. C2 - 20650905. AN - SCOPUS:77957241620. VL - 25. JO - Nephrology Dialysis Transplantation. JF - Nephrology Dialysis Transplantation. SN - 0931-0509. IS - 10. ER - ...
Results Demographic and laboratory characteristics revealed significant differences in sex (female of SLE vs. AAV, 93.8% vs. 61.1%, p=0.043) and in platelet count (SLE vs. AAV, 51,310±50,194 vs. 278,780±112,393/mm3, p,0.001) between AAV and SLE patients. The mean age was different in both groups (SLE vs. AAV, 38.7±18.6 vs. 50.9±19.1) but showed only a marginal significance (p=0.067). The number of involved organs was higher in SLE patients (SLE vs. AAV, 4.3±1.1 vs. 3.1±0.7, p=0.005), whereas the frequency of renal involvement and renal insufficiency (peak creatinine threshold≥150umol/L), and intensity of proteinuria were similar in both groups. There were no differences in the therapeutic modalities (intravenous immunoglobulin, cyclophosphamide pulse therapy, steroid pulse therapy, and plasmapheresis) and frequency of mechanical ventilation in both groups. The mortality rate was 66.7% (12/18) and 56.3% (9/16) in AAV and SLE patients with DAH, respectively (p=0.725). Among the deceased ...
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Over a period of five years all consecutive patients with active RA, admitted to the rheumatology ward of the University Medical Center, Utrecht, to undergo CPT to bridge the lag time of a newly started DMARD, were included in this study after informed consent. If a patient was admitted more than once for CPT in this period of five years, only the first admission was used. None of the 66 patients receiving CPT (CPT group) refused to participate. Active disease was defined as the presence of at least two of the following three criteria: Thompson joint score ,10,9 erythrocyte sedimentation rate (ESR) ⩾28 mm/1st h, and early morning stiffness ⩾1 hour. Each CPT regimen comprised three doses of 200 mg dexamethasone (each dose 1000 mg methylprednisolone equivalent), given through an intravenous infusion on alternate days over a five day period.. At admission and 1-2 days before discharge from the hospital, the following variables were assessed: ESR, C reactive protein level (CRP), haemoglobin ...
Currently approved drug therapy for AIS is limited by the need to treat within 3 hours of symptom onset. Alfimeprase acts to degrade fibrin directly and is inactivated locally by circulating alpha-2 macroglobulin. This study will determine whether treatment with alfimeprase facilitates rapid restoration of arterial blood flow with avoidance of symptomatic hemorrhagic conversion in subjects with AIS within 3 to 9 hours of symptom onset ...
Pattern of steroid resistant nephrotic syndrome in children living in the kingdom of Saudi Arabia: a single center study.: Steroid resistant nephrotic syndrome
Corticosteroids, administered through topical, periocular, oral, or intravenous routes, stay the mainstay of treatment for corneal graft rejection 1 Intravenous pulse methylprednisolone (500-1,000 mg for 3 days) has been thought to reset the immune system and could also be associated with superior graft survival when administered throughout the first week of the rejection episode 9 Subconjunctival or posterior subtenon triamcinolone injections, together with topical steroids, have been thought of valid alternatives within the therapy of endothelial rejection 10 On this case, after no improvement within the signs of graft rejection was famous with intravenous pulse methylprednisolone therapy, along with an hourly topical steroid, a subtenon triamcinolone injection within the superotemporal quadrant produced important clearing within the superior half of the cornea on comply with-up 1 week later.. ...
Corticosteroid resistant and dependent nephrotic syndrome in children is a challenge and there are some difficulties in treating such patients. We reviewed the current studies that evaluated therapeutic role of a relatively new immunosuppressive drug "rituximab" in reducing proteinuria and reduction of relapse rate in less than 16 year old patients with non-responsive or steroid dependent nephrotic syndrome. We searched Medline, Embase, web of science and Cochrane library with appropriate keywords and conducted the complete remission, relapse rate and the mean number of relapses 12 month after therapy on Meta-analysis. We put the data on two different subgroups; steroid resistant nephrotic syndrome and steroid dependent or frequent relapser nephrotic syndrome. In Steroid Resistant Nephrotic syndrome children, the complete remission was 0.27 (0.2- 0.34). In Steroid Dependent Nephrotic syndrome patients, the overall standard mean differences of mean number of relapses 12 mo after treatment in ...
This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive
On study CCG-161 of the Childrens Cancer Study Group (CCSG), 631 children with acute lymphoblastic leukemia (ALL) at low risk for relapse were randomized to receive monthly pulses of vincristine-prednisone (VCR-PDN ) during maintenance therapy in addition to standard therapy with mercaptopurine (6MP) and methotrexate (MTX), and either cranial irradiation during consolidation or intrathecal (IT) MTX every 3 months during maintenance. All patients received six doses of IT MTX during induction and consolidation. With a minimum follow-up time of 4.25 years, 76.7% receiving VCR-PDN were in continuous complete remission at 5 years, in contrast to 63.9% receiving 6MP-MTX alone (P = .002). The difference in relapse-free survival was due primarily to bone marrow relapse (P = .0008), and in boys also to testicular relapse (P = .003). Among the nonirradiated patients, the 5-year disease-free survival (DFS) was 79.4% for patients randomized to the VCR-PDN pulses, in contrast to 61.2% for the patients ...
Authors: Miyamoto K, Kozu S, Arakawa A, Tsuboi T, Hirao JI, Ono K, Arisaka O.. Acute disseminated encephalomyelitis confined to the brainstem is associated with poor prognosis. We describe a case of a 10-year-old boy with acute disseminated encephalomyelitis in the brainstem that developed after influenza A infection. A 10-year-old boy presented with fever and prolonged disturbance of consciousness and was admitted to our hospital. Magnetic resonance imaging (MRI) of the midbrain, with T2-weighted and fluid-attenuated inversion recovery images, suggested acute disseminated encephalomyelitis accompanied by a brainstem lesion. Lumbar puncture showed pleocytosis and increased protein content, including myelin basic protein, interleukin-6, and immunoglobulin G, all suggestive of acute disseminated encephalomyelitis. Treatments such as methylprednisolone pulse therapy, intravenous immunoglobulin, and therapeutic hypothermia were performed. Although the patient presented with anisocoria with increased ...
ABSTRACT: BACKGROUND: Most patients with steroid sensitive nephrotic syndrome (SSNS) have frequent relapses until disease resolve spontaneously toward the end of second decade of life and so the main problem in such disease is frequent relapses and their association with complications of disease or side effects of drugs used in each relapse. OBJECTIVE: In this study, we evaluate different factors which might be associating or leading to occurrence of frequent relapses. PATIENTS AND METHODS: A retrospective study was done in the Central Child Teaching Hospital from Feb. 2007 - Feb. 2008, during this period, 120 patients with nephrotic syndrome (NS) randomly selected who were diagnosed & or treated in this hospital. Out of 120 patients, 85 (70.8%) patients with steroid sensitive nephrotic syndrome (SSNS), 9 (7.5%) patients with steroid dependant nephrotic syndrome (SDNS) and 26 (21.7%) patients with steroid resistant nephrotic syndrome (SRNS). The steroid sensitive patients were divided into 24 ...
Dr Salim Çaliskan is a professor of Pediatric Nephrology. He has been partipating in the ESCAPE network since 2002. His main research interests include steroid resistant nephrotic syndrome, congenital anomalies of the kidney and urinary tract, cardiovascular morbitidies in children with chronic renal disease, as well as hemodialysis. He participated in the original ESCAPE study and is now involved in the 4C, PodoNet, ADPKiD, and 3H studies. ...
|p|We report a 71-year-old male with microscopic polyangiitis (MPA) who developed sudden-onset, progressive, bilateral visual loss associated with a relapse of MPA symptoms. The patient was referred to our hospital, and treated with intravenous pulse steroid therapy and high-dose oral prednisolone. Although the right eye remained vision deficient, visual acuity in the left eye recovered. Ocular manifestations of MPA are quite uncommon. This case emphasizes the necessity of early detection and initiation of prompt therapy where ocular manifestations of MPA occur.|/p|
Linnaeus, C. 1753. Species plantarum, exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas. Tomus I. Pp. [I-XII], 1-560. Impensis Laurentii Salvii, Holmiae [Stockholm]. BHL Reference page. : 458. ...
The benefits of PEMF have been demonstrated through more than 2,000 university-level, double-blind, medical studies conducted in many countries. PEMF has been shown to destroy cancer cells, to re-differentiate unhealthy and inflamed cells, to activate DNA repair, and to cause apoptosis (cellular suicide) in cancer and inflamed cells ...
Dallas, Texas cosmetic surgery specialist, Dr. True, specializes in body procedures, including Cellulite treatments, to enhance the contour and smoothness of the skin.
In a cardioverter/defibrillator system, an electrical circuit includes an energy storage device, an output circuit for controlling delivery of pulse therapy from the energy storage device to a patient, and a sensing circuit coupled across the patient to sense the patients heart signal. The output circuit may be in the form of an H-bridge switching circuit wherein a pair of switches of the output circuit is simultaneously turned on to discharge residual voltage across the patient that remains after delivery of pulse therapy. Thus, interference with sensing of the patients heart signal is avoided.
The patient was diagnosed with PAN1,2. The typical aneurysms and stenoses in conventional angiography are the hallmarks of PAN3. Our patient was initially treated with 1 g of methylprednisolone intravenously (IV) in 3 subsequent days, followed by 80 mg of oral prednisolone daily and monthly IV cyclophosphamide pulses of 700 mg/m3. A rapid improvement of clinical signs and inflammation was noted after the initiation of treatment.. Sixteen months later, the patient continued to be in remission with 150 mg/day of azathioprine and 5 mg/day of prednisolone. The patient has not been re-evaluated with conventional angiography; however, a CT angiography of the abdomen performed after 16 months did not reveal any signs of liver or medium-sized vessel pathology. The noteworthy aspect of our case is the dramatic and fulminant presentation of PAN with aneurysm rupture and abdominal hemorrhage, accompanied by minimal clinical symptoms. ...
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high pulse - MedHelps high pulse Center for Information, Symptoms, Resources, Treatments and Tools for high pulse. Find high pulse information, treatments for high pulse and high pulse symptoms.
You dont happen to have the "Work offline" option checked, do you? Because that will block any pulses you try to do. There are no attempts to pulse from you, so Im guessing you enabled that option ...
Has anyone experienced a rapid pulse after the Liberation procedure? I had my procedure June 23 and since then my pulse is 100-110. Normally it is 70.
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ഹൃദയമിടിപ്പ് മൂലം ധമനികളിൽ ഉണ്ടാവുന്ന സ്പന്ദനം സ്പർശത്തിലൂടെ തിരിച്ചറിയുന്നതാണ് Pulse അഥവാ നാഡീസ്പന്ദനം/നാഡിപ്മിടിപ്പ് എന്ന് പറയുന്നത്. നെഞ്ചിടിപ്പ്, ഹൃദയമിടിപ്പ്, തുടിപ്പ്, ഹൃദയസ്പന്ദനം എന്നെല്ലാം പറയുന്നത് പൾസ് തന്നെയാണ്. മൂലം. ശരീരോപരിത്തലത്തിനടുത്തള്ള ഏതെങ്കിലും അസ്ഥിക്ക് സമീപത്തുകൂടി പോകുന്ന ധമനി, ആ അസ്ഥിതിയോട് ചെർത്തുപിടിച്ച് സ്പന്ദനം എണ്ണിയാണ് പൾസ് ...
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Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis/anhidrosis (AIGA) includes idiopathic pure sudomotor failure (IPSF), which has the following distinct features: sudden onset in youth, increased serum immunoglobulin E and responds favorably to systemic corticosteroid. No clinical markers reflecting the disease severity or activity have been established. Here, we report a case of AIGA in a Japanese patient successfully treated with repeated methylprednisolone pulse therapy. In this case, serum carcinoembryonic antigen (CEA) levels increased up to 19.8 ng/mL along with aberrant CEA immunoreactivity of eccrine sweat glands. Interestingly, the serum CEA level normalized as sweating improved with repeated methylprednisolone pulse therapy. Therefore, serum CEA level may serve as a useful clinical marker of hypohidrosis or anhidrosis.
TY - JOUR. T1 - Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila. AU - Moeller, Morten E.. AU - Danielsen, E. Thomas. AU - Herder, Rachel. AU - OConnor, Michael B.. AU - Rewitz, Kim F.. N1 - This work was supported by the Danish Council for Independent Research,Natural Sciences [grant 11-105446 to K.F.R.] and the National Institutes of Health[grant R01 GM093301 to M.B.O.]. PY - 2013. Y1 - 2013. N2 - Steroid hormones trigger the onset of sexual maturation in animals by initiating genetic response programs that are determined by steroid pulse frequency, amplitude and duration. Although steroid pulses coordinate growth and timing of maturation during development, the mechanisms generating these pulses are not known. Here we show that the ecdysone steroid pulse that drives the juvenile-adult transition in Drosophila is determined by feedback circuits in the prothoracic gland (PG), the major steroid-producing tissue of insect larvae. These ...
Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
Hepatitis C-associated osteosclerosis (HCAO), a very rare disorder in which an extremely rapid bone turnover occurs and results in osteosclerosis, was acknowledged in 1990s as a new clinical entity with the unique bone disorder and definite link to chronic type C hepatitis, although the pathogenesis still remains unknown. Affected patients suffer from excruciating deep bone pains. We report the 19th case of HCAO with diagnosis confirmed by bone biopsy, and treated initially with a bisphosphonate, next with corticosteroids and finally with direct acting antivirals (DAA: sofosbuvir and ribavirin) for HCV infection. Risedronate, 17.5 mg/day for 38 days, did not improve the patients symptoms or extremely elevated levels of bone markers, which indicated hyper-bone-formation and coexisting hyper-bone-resorption in the patient. Next, intravenous methylprednisolone pulse therapy followed by high-dose oral administration of prednisolone evidently improved them. DAA therapy initiated after steroid ...
TY - JOUR. T1 - Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy. AU - Takahashi, Keigo. AU - Sato, Hideki. AU - Hattori, Hidenori. AU - Takao, Masaki. AU - Takahashi, Shinichi. AU - Suzuki, Norihiro. PY - 2017. Y1 - 2017. N2 - A 28-year-old Japanese male without a significant past medical history presented with new-onset generalized clonic seizure and headache. A brain MRI revealed multiple enhanced lesions on both cerebral hemispheres. Laboratory exams showed no evidence of systemic inflammation or auto-immune antibodies such as ANCAs. Despite four courses of high-dose methylprednisolone pulse therapy and five treatments with plasmapheresis, his symptoms worsened and the MRI lesions progressed rapidly. During these treatments, we performed a targeted brain biopsy, that revealed histological findings consistent with a predominant angiitis of parenchymal and subdural small vessels. He was provided with ...
All patients initially treated with systemic corticosteroids alone: optional IV methylprednisolone pulse (15 mg/kg) at treatment start followed by oral prednisone (1 mg/kg/day) according to a tapering schedule. Treating physicians allowed to treat minor relapses with corticosteroids without referring the patient for randomization, as long as the prednisone dose did not exceed 0.5 mg/kg for 1 month.. Patients in whom prednisone doses could not be tapered below 20 mg, those who failed to enter remission and those who relapsed were randomized to receive either 6 months of oral azathioprine (2mg/kg/day) or 6 cyclophosphamide pulses (0.6g/m2 D1, D15, D30 then every month) ...
Idiopathic nephrotic syndrome (INS) is the most frequent form of NS in children. INS is defined by the association of the clinical features of NS with renal biopsy findings of minimal changes, focal segmental glomerulosclerosis (FSGS), or mesangial proliferation (MP) on light microscopy and effacement of foot processes on electron microscopy. Actually the podocyte has become the favourite candidate for constituting the main part of the glomerular filtration barrier. Most cases are steroid sensitive (SSINS). Fifty percents of the latter recur frequently and necessitate a prevention of relapses by nonsteroid drugs. On the contrary to SSINS, steroid resistant nephrotic syndrome (SRINS) leads often to end-stage renal failure. Thirty to forty percents of the latter are associated with mutations of genes coding for podocyte proteins. The rest is due to one or several different circulating factors. New strategies are in development to antagonize the effect of the latter.
A 10-year-old boy presented with persistent proteinuria and hematuria detected by a school urine screening. Based on renal biopsy findings, the patient was diagnosed with IgA nephropathy Hass class IV. He was treated with deflazacort for two weeks, and then, AZA was given at an initial daily dosage of 25 mg (0.8 mg/kg) and increased to 50 mg (1.6 mg/kg) per day two weeks after the initial visit. When the patient had taken AZA for 4 weeks, he started to complain of hair loss. Suspecting a side effect of the AZA, the dosage of the AZA was reduced to 25 mg per day. Two weeks after the dose reduction (six weeks after he started AZA), the patient visited the emergency center with fever for two days. He also had a sore throat and mild cough. His vital signs were as follows: blood pressure, 101/59 mmHg; pulse rate, 114 beats/min; respiratory rate, 20 breaths/min, and body temperature, 39.6℃. On physical examination, alopecia totalis (Fig. 1) was observed as well as two slightly hypertrophic tonsils. ...
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An example of an acute hepatitis-like syndrome arising after pulse methylprednisolone therapy. These episodes arise typically 2 to 4 weeks after a third or fourth cycle of pulse therapy, and range in severity from an asymptomatic and transient
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Results Data for 20 patients were collected; 16 patients had primary MPA (4 boys, 12 girls), with a median age of 8.9 years at the time of disease onset; 4 patients, all female, had antithyroid drug (ATD)-associated MPA, with an age range of 12.5 to 16.2 years at the time of disease onset. All patients exhibited renal involvement. Renal biopsies were performed in 14 patients. Fibrinoid exudation and necrosis of the glomerular capillaries were observed in all biopsy specimens. Crescents and scleroses were noted in 92.9% and 85.7% of these cases, respectively. The most frequent extrarenal organs involved were lungs, followed by the central nervous system (CNS), skin, and digestive system. Ninety percent of patients were positive for perinuclear antineutrophil cytoplasmic antibody, 94.1% were positive for myeloperoxidase, and 88.2% were positive for both. Forty-five percent of the patients had received steroid plus cyclophosphamide (CTX) pulse therapy for more than 3 months, and varying degrees of ...
Rheumy appointment today. Im not expecting much, basically start over, but maybe she can get me off the steroids. I read in a new book on lupus I got that the steroid use causes the thickening waist (which I have-I lost all that weight and yet my stomach area stayed the same), which later can lead to diabetes. Its caused from the hormonal component of the Prednisone. That, the skin problems (pimples) and other stuff. I am not on a high dose at all (but was for a while), but would like to stop all together. In reality, I dont think its lupus, but an unknown connective tissue disorder. Ive done a lot of the drug treatments, methotrexate injections, steroids, pulse therapy, Plaquenil and none seemed to help-most made shit worse. Im just tired of it all ...
Not too long after Annyka was born, in November of 2005, I started getting some swelling in my neck, below the ear and behind my jaw. I dont remember which side of my face it was on, but it doesnt really matter. It progressively got worse over a few weeks, but I had also been having some severe allergies and inner ear fluid causing vertigo, so I was assuming that it was all related and that the meds my doc had already prescribed would help. The Sunday after Thanksgiving I could barely eat due to the swelling and pain and my body was feeling achy and exhausted with infection so I went to the doctor. Antibiotics were prescribed. They didnt help. More antibiotics were prescribed. Still little change. The infection would clear up, but the swollen gland didnt get better. Eventually with the help of acupuncture, TENS electric pulse therapy and A LOT of warm compresses and massage the area drained and went down. ...
An open brain biopsy from the right frontal cortex revealed CAA with giant cell activation around the amyloid deposition (Fig 1C). The patient was treated with intravenous methylprednisolone, 1 g daily for 3 days, followed by corticosteroid treatment with a maximum dose of 60 mg, tapering off within 3 months. During treatment, he improved, and at the 1-month follow-up consultation, he walked without support and was able to care for himself at home. On examination, he rose from the chair and walked across the room without difficulty. T1-weighted MR imaging showed regression of the mass lesion and almost normalization of the ventricle asymmetry, but meningeal contrast enhancement persisted (Fig 1D). Four months later, he relapsed with recurrent weakness of the left leg and unsteady gait. Consequently, we administered intravenous cyclophosphamide, 1200 mg at 3-week intervals for 1 year, which resolved the neurologic deficits. During the treatment period and at 15-month follow-up, he remained ...
A system provides an input pump pulse and a signal pulse. A first dichroic beamsplitter is highly reflective for the input signal pulse and highly transmissive for the input pump pulse. A first optical parametric amplifier nonlinear crystal transfers part of the energy from the input pump pulse to the input signal pulse resulting in a first amplified signal pulse and a first depleted pump pulse. A second dichroic beamsplitter is highly reflective for the first amplified signal pulse and highly transmissive for the first depleted pump pulse. A second optical parametric amplifier nonlinear crystal transfers part of the energy from the first depleted pump pulse to the first amplified signal pulse resulting in a second amplified signal pulse and a second depleted pump pulse. A third dichroic beamsplitter receives the second amplified signal pulse and the second depleted pump pulse. The second depleted pump pulse is discarded.
Depo Medrol for dogs and cats, the generic of methylprednisolone, is an anti inflammatory drug that is useful in the treatment of a wide range of diseases, helping to bring down swelling caused by an infection or allergic reaction, making it easier to treat the issue. Learn more about Depo Medrol works here.
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I was really fat, during last ten years. And I resigned myself to it. But when I saw like my sister got rid of 8 pounds during 2 weeks, I decided to take advantage of her secret - Ayurslim! During first ten days I lost more than 3 pounds and I feel myself really good, so I will continue to use Ayurslim until Ill be satisfied ...
Is 2018 going by really fast or what? As much as January really took its time, February is here and I am grateful as always. The last time I wrote a Pulse for a month post was in August 2017. Staying off writing my goals was not intentional but if you have been a reader…
perhaps if we could just get on with the medicine and werent the answer to everyones ills - ie someones else did it then we would all be happier ...
Results Case 1: A 23 year-old female SLE patient with central and peripheral nervous system (CNS and PNS) involvements for 5 years, presented pan-dysautonomia, including severe orthostatic hypotension, dysuria and gastro-intestinal psedo-obstruction. Acetylcholine-receptors (AChR) antibody was detected in her cerebrospinal fluid (CSF). After treating with prednisone, tacrolimus, midodrine and fludrocortisone, her symptoms gradually improved in 12 months. Case 2: A 44 year-old female presented with pan-dysautonomia, anti-nuclear and anti-Ro antibody positivity and hypocomplementemia. AChR antibody titer also elevated in her CSF. After similar treatment, and additional plasma exchange for 6 times, all symptoms improved in 3 months. Comblined with other 8 reported cased, 9 were female, 4 and 3 cases complicated with CNS and PNS involvement respectively, 3 cases had AChR antibody detected and all were postive, 4 cases received methylprednisolone pulse therapy. Cyclophosphamide (n=3), azathiopurine ...