Surfactant protein A1 (SP-A or SP-A1) is a member of the C-type lectin family of proteins, known as collectins. In humans, it is encoded by the SFTPA1 gene. SP-A is the major protein component of pulmonary surfactant, a lipoprotein complex secreted by the alveolar type II cell. Pulmonary surfactant reduces surface tension in the alveolus and prevents alveolar collapse during exhalation. In addition to its role as a surfactant, SP-A modulates the alveolar immune response to microbes and inhaled particulate matter. SP-A is also expressed in nonalveolar cells, and is thought to be involved in functions such as immune cell proliferation, stimulation of proinflammatory cytokine expression, and control of reactive oxygen species. Mutations in the SFTPA1 gene are associated with idiopathic pulmonary fibrosis. SP-A is also known as alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein, pulmonary surfactant-associated protein A1, surfactant protein A1B, collectin-4, SP-A1, PSAP, ...
Surfactant protein A1 (SP-A or SP-A1) is a member of the C-type lectin family of proteins, known as collectins. In humans, it is encoded by the SFTPA1 gene. SP-A is the major protein component of pulmonary surfactant, a lipoprotein complex secreted by the alveolar type II cell. Pulmonary surfactant reduces surface tension in the alveolus and prevents alveolar collapse during exhalation. In addition to its role as a surfactant, SP-A modulates the alveolar immune response to microbes and inhaled particulate matter. SP-A is also expressed in nonalveolar cells, and is thought to be involved in functions such as immune cell proliferation, stimulation of proinflammatory cytokine expression, and control of reactive oxygen species. Mutations in the SFTPA1 gene are associated with idiopathic pulmonary fibrosis. SP-A is also known as alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein, pulmonary surfactant-associated protein A1, surfactant protein A1B, collectin-4, SP-A1, PSAP, ...
In the 35-residue pulmonary surfactant-associated lipopolypeptide C (SP-C), the stability of the valyl-rich alpha-helix comprising residues 9-34 has been monitored by circular dichroism, nuclear magnetic resonance, and Fourier transform infrared spectroscopy in both a mixed organic solvent and in phospholipid micelles. The alpha-helical form of SP-C observed in freshly prepared solutions in a mixed solvent of CHCl3/CH3OH/0.1 M HCl 32:64:5 (v/v/v) at 10 degrees C undergoes within a few days an irreversible transformation to an insoluble aggregate that contains beta-sheet secondary structure. Hydrogen exchange experiments revealed that this conformational transition proceeds through a transition state with an Eyring free activation enthalpy of about 100 kJ mol(-1), in which the polypeptide segment 9-27 largely retains a helical conformation. In dodecylphosphocholine micelles, the helical form of SP-C was maintained after seven weeks at 50 degrees C. The alpha-helical form of SP-C thus seems to be ...
Principal Investigator:UEDA Takashi, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Respiratory organ internal medicine
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
... allows for the in vitro quantitative determination of Bovine Surfactant-associated protein 2, SFTA2 concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Looking for online definition of Pulmonary surfactant-associated protein a in the Medical Dictionary? Pulmonary surfactant-associated protein a explanation free. What is Pulmonary surfactant-associated protein a? Meaning of Pulmonary surfactant-associated protein a medical term. What does Pulmonary surfactant-associated protein a mean?
TY - JOUR. T1 - Glucocorticoid inhibition of human SP-A1 promoter activity in NCI-H441 cells. AU - Hoover, Russell R.. AU - Thomas, Klaus H.. AU - Floros, Joanna. PY - 1999/5/15. Y1 - 1999/5/15. N2 - Glucocorticoids have complex effects on human surfactant protein (SP) SP-A1 and SP-A2 gene expression that occur at both transcriptional and post-transcriptional levels. In the lung adenocarcinoma cell line NCI-H441, dexamethasone causes a dose-dependent decrease in total SP-A mRNA levels and inhibits SP-A gene transcription. In this study, a deletional analysis of the SP-A1 promoter was performed in order to identify cis-acting elements that mediate dexamethasone responsiveness in NCI-H441 cells. The region -32/+63 relative to the start of SP-A1 transcription mediated both basal promoter activity and dexamethasone repression of transcription. Removal of the region +18/+63 abolished dexamethasone responsiveness, indicating that sequences within this region are necessary for the inhibitory effect. ...
Effect of calcium on phospholipid interaction with pulmonary surfactant protein C.: Porcine pulmonary surfactant-associated protein SP-C was incorporated into b
Research efforts in the Bridges laboratory are focused toward understanding the molecular regulation of epithelial cell specification and maturation during lung development and determining the molecular mechanisms that control pulmonary surfactant pool sizes in the postnatal and adult lung, with particular interest in rare pediatric and adult lung diseases associated with surfactant dysfunction.
Cattle;Amyloid;Pulmonary Surfactant-Associated Protein C;Cysteine;Water;Pulmonary Alveolar Proteinosis;Amyloidogenic Proteins;Amyloidosis;Acylation;Spectrophotometry, Infrared;Lipoproteins;Lipids;Spectrum Analysis;Molecular Conformation;Serum ...
Supplementary Materialsoncotarget-09-6518-s001. This demonstrates the significant potential of alveolar type II cells in orchestrating the process of metastasis, rendering it as one of the target cell types of the lung of therapeutic importance in human NSCLC. expression is usually replaced with reddish fluorescent protein (DsRed*MST) expression in tissues expressing Cre recombinase. We utilized transgenic mice in which the human SPC (Sftpc) gene promoter is used expressing the invert tetracycline transactivator (rtTA) hence placing the appearance of Cre-recombinase (CRE) beneath the conditional control of doxycycline. Appearance of Cre was utilized to completely label cells with Crimson fluorescent proteins (DsRed) in alveolar type II cells. Distinctive lines of transgenic mice that exhibit rtTA beneath the control of the individual surfactant-associated proteins C (Sftpc/SPC) gene promoter had been bred VE-821 enzyme inhibitor to TetO-Cre mice and reporter mice (LacZ/DsRed) creating triple ...
Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases (ILDs). Furthermore, a mutation in the surfactant protein C gene that results in complete absence of the protein has been shown to be associated with familial ILD. The role of surfactant in lung disease is therefore drawing increasing attention following the elucidation of the genetic basis underlying its surface expression and the proof of surfactant abnormalities in ILD.
The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-R210S isoforms, splicing of small exons generates alternate forms of the unique carboxy-terminal domain name of Myo18A in macrophages [6]. Moreover, recent work offered in abstract form suggested that alternate splicing introduces […]. ...
Dr. Ledfords current work in the area of pulmonary surfactant immunobiology combines her knowledge of mouse genetics, pulmonary disease models and immune function regulation and focuses on understanding the role of Surfactant Protein-A (SP-A) and how it regulates signaling pathways within various immune cell populations. Specifically, she is interested in how SP-A regulates degranulation, either directly or indirectly, of two important cell types in asthma: mast cells and eosinophils. More recently, Dr. Ledfords research has focused on understanding how genetic variation within human SP-A2 alters functionality of the protein in relation to eosinophil activities and how this translates to characteristics observed in human asthma.. ...
A mild, multi-phase cleansing composition is described that includes a cleansing phase including a structured surfactant component has a first density; a benefit phase includes an emulsion, the benefi
Lung surfactant reduces surface tension and maintains the stability of alveoli. How surfactant is released from alveolar epithelial type II cells is not fully understood. Vacuolar ATPase (V-ATPase) is the enzyme responsible for pumping H+ into lamellar bodies and is required for the processing of surfactant proteins and the packaging of surfactant lipids. However, its role in lung surfactant secretion is unknown. Proteomic analysis revealed that vacuolar ATPase (V-ATPase) dominated the alveolar type II cell lipid raft proteome. Western blotting confirmed the association of V-ATPase a1 and B1/2 subunits with lipid rafts and their enrichment in lamellar bodies. The dissipation of lamellar body pH gradient by Bafilomycin A1 (Baf A1), an inhibitor of V-ATPase, increased surfactant secretion. Baf A1-stimulated secretion was blocked by the intracellular Ca2+ chelator, BAPTA-AM, the protein kinase C (PKC) inhibitor, staurosporine, and the Ca2+/calmodulin-dependent protein kinase II (CaMKII), KN-62. Baf A1
Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. SFTPD is an innate immune system collectin. Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of influenza A virus. pulmonary surfactant GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116-26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081. Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795-802. PMC 1132609 . PMID 1339284. "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D". Brandt EB, Mingler ...
Rab38 small GTPase regulates intracellular transport in melanocytes and alveolar type II epithelial cells. Ruby rats carrying Rab38 and other gene mutations exhibit oculocutaneous albinism, bleeding diathesis, and hence, are a rat model of human Hermansky-Pudlak syndrome (HPS). We previously showed that Long Evans Cinnamon (LEC) rats, one strain of the Ruby rats, developed aberrant lung surfactant homeostasis with remarkably enlarged lamellar bodies in alveolar type II cells. A replication-deficient recombinant adenovirus expressing rat Rab38 (Ad-Rab38) was constructed. Alveolar type II cells were isolated from the LEC rats and tested for lung surfactant phosphatidylcholine secretion. The rats were also examined whether exogenous expression of Ad- Rab38 could rescue the altered lung surfactant homeostasis in the lungs. Isolated type II cells infected with Ad-Rab38 exhibited improved secretion patterns of [3H]phosphatidylcholine, i.e. increased basal hyposecretion and decreased agonist-induced
Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism. The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice. Mice which gestate for 19 days typically show signs of SP-A in amniotic fluid at around 16 days. If SP-A is injected into the uterus at 15 days, mice typically deliver early. Inversely, an SP-A inhibitor injection causes notable delays in birth. The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans. In fact, the level of ...
The attachment of cells to a base, i.e. basement membrane in vivo or tissue culture plate in vitro, has been shown to be important in maintaining basic cell function (Shannon et al., 1987). The cells isolated from M. eugenii in this experiment did not adhere to the tissue culture plates but remained as a suspended monolayer just above the base of the plate. However, these cells appear to retain their original morphology, including the presence of lamellar bodies (Fig. 5A,B), and function (e.g. their ability to secrete proteins and lipids). Secretion studies have also been performed on suspended cells from another marsupial, the fat-tailed dunnart (Ormond et al., 2001), as well as a lizard, frog and lungfish (Wood et al., 1999, 2000).. At 30 days of age, the basal secretion of PC was significantly higher than that at 70 days, suggesting that, at this early stage, the cells are extremely active and they secrete very large amounts of surfactant. This finding, therefore, supports the morphological ...
PURPOSE: We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy. METHODS: Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-cRFLP methods. RESULTS: The distribution for the alleles of the SP-A2 gene in the study population was 1A, 1A0, 1A1, 1A2, 1A3, 1A5, 1A6, 1A7, 1A8, 1A9, 1A11, 1A12. The specific frequencies for the alleles of the SP- A2 gene in the study population were : 1A=11.3%, 1A0=38%, 1A1=12.7%, 1A2=9.2%, 1A5=15.5%, 1A7= 2.9%, 1A8=4.9%, 1A9=2.2%, others=3.3%. CONCLUSION: The frequency of 1A0 was higher than the other SP-A2 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that ...
Notch is an ancient cell-signaling system that regulates the specification of cell fate. Recently, Notch was found to confer antigen presenting cell function on mast cells, induce histamine release in human basophils and regulate migration and survival of eosinophils.. In acute lung injury, alveolar type II cells activate macrophages, secrete soluble mediators, migrate and spread in response to the injury. Additionally, Notch stimulated myofibroblast differentiation and migration of cultured RLE-6TN cells. However, until now, nothing is known on the role of Notch activation regarding proliferation of rat alveolar type II cells.. Rat alveolar type II cells (RLE 6TN) were obtained from the American Type Culture Collection (ATCC no. CRL-2300; Manassas, VA, USA) and were cultured in DMEM/Hams F12 containing 10% fetal calf serum and L-glutamine. Cell proliferation was measured by direct cell count and the fluorometric proliferation assay EZ4U basing on tetrazolium salt reduction. Cells were ...
The present invention discloses various embodiments and examples of a thickened aqueous abrasive cleanser capable of maintaining a smoothly flowable or plastic consistency over long periods of time. The cleanser is characterized by the ability to stably suspend abrasives while exhibiting excellent shelf stability over long periods of time with substantially no syneresis and being suitable for use where environmental requirements prevent the use of phosphates. This cleaner has the following ingredients: (a) a colloidal alumina thickener having an average particle size, in dispersion, of no more than about one micron; (b) an electrolyte/buffer; (c) a surfactant system including two surfactant components, one surfactant component comprising a fatty acid anionic surfactant, the other surfactant component comprising a selected bleach-stable surfactant or mixed surfactant; (d) a bleach; and (e) a particulate abrasive having an average particle size of about one to as much as 400 microns to provide scouring
Adult hamsters were exposed to 100% oxygen for up to 8 days. At time of death lung tissue was analyzed for the expression of surfactant protein (SP) genes, and surfactant was isolated from alveolar lavage fluid. Surfactant was analyzed for the composition of proteins and phospholipids and for its surface properties. We found, over the 8 days of exposure, that an alveolitis composed of polymorphonuclear leukocytes (PMNs) and alveolar macrophages, accompanied by exudation of edema fluid, appeared in the alveolar spaces. The steady-state levels of SP mRNAs declined after 8 days of exposure to 100% oxygen, but the patterns indicated individual genetic control. SP-A was elevated early in the course of the hyperoxic exposure but decreased significantly by day 8; SP-B decreased continuously; SP-C was unchanged (or slightly elevated) through day 2 and then declined. The amounts of recoverable lavage surfactant increased by greater than threefold, and the phospholipid composition showed increasing percentages of
Surfactant protein D小鼠单克隆抗体[10B2](ab26267)可与人样本反应并经WB, ELISA实验严格验证,被4篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Smith, L J., "The effect of type 2 cell mitosis on the surfactant system of injured mouse lungs." (1983). Subject Strain Bibliography 1983. 1719 ...
This powerful degreaser is the naturally preferred solution for all degreasing task. A synergistic blend of natural ingredients with a unique surfactant system produces a formula that equals most traditional degreasers. This unique degreaser breaks down greases, oils, and fats including industrial petroleum greases on all water safe surfaces.. ...
辛酸/癸酸甘油三酯聚乙二醇酯类 - 表面活性剂 - 表面活性剂百科 - 表面活性剂百科(Surfactant.TOP),表面活性剂,阴离子表面活性剂,阳离子表面活性剂,非离子表面活性剂,两性离子表面活性剂,氟表面活性剂,硅表面活性剂,纯天然表面活性剂,高分子表面活性剂,生物表面活性剂,特殊表面活性剂 - 第1页
乙氧基化月见草油甘油酯类 - 表面活性剂 - 表面活性剂百科 - 表面活性剂百科(Surfactant.TOP),表面活性剂,阴离子表面活性剂,阳离子表面活性剂,非离子表面活性剂,两性离子表面活性剂,氟表面活性剂,硅表面活性剂,纯天然表面活性剂,高分子表面活性剂,生物表面活性剂,特殊表面活性剂 - 第1页
We quantified the effects of continuous exposure to 100% 02 on the development of sublethal injury to the pulmonary alveolar epithelium of rabbits. There was a progressive increase in alveolar permeability to solute after 48 h in 0 which coincided with the onset of damage to the pulmonary microvasculature. Rabbits that were exposed to 100% O2for 64 h and returned to room air for 24 h had, in addition to increased permeability to solute, decreased phospholipid levels, decreased total lung capacity, pulmonary edema, high minimum surface tensions in their bronchoalveolar lavage, and moderate hypoxemia. Intratracheal instillation of calf lung surfactant (CLSE) significantly ameliorated the progression of hyperoxic injury by increasing alveolar phospholipid levels and thus preventing the inhibition of lung surfactant activity by plasma proteins and other high molecular weight components of alveolar edema. We concluded that the alveolar epithelium and the pulmonary microvasculature show similar ...
Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions (1). Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. The collectins play an important role in innate immunity by binding to specific carbohydrate structures found on the surfaces of pathogenic microorganisms, including bacteria, viruses, yeasts, and parasitic protozoa. The binding promotes effector mechanisms such as aggregation, hindrance of infection, activation of phagocytes, and initiation of phagocytosis. After binding to microbial surfaces, MBL activates the complement system through a complement activation pathway, the MBL pathway, by using two recently identified serine proteases, MASP-1 and MASP-2, to activate C4 and C2 (2).. SP-D is mainly produced by alveolar type II cells but is also present in sweat, salivary, tear, and mammary glands ...
TY - JOUR. T1 - Dynamic surface activity of films of lung surfactant phospholipids, hydrophobic proteins, and neutral lipids. AU - Wang, Z.. AU - Hall, S. B.. AU - Notter, R. H.. PY - 1995. Y1 - 1995. N2 - Surface pressure area (Π-A) isotherms during dynamic cycling were measured for films of dipalmitoyl phosphatidylcholine (DPPC) and column- separated fractions of calf lung surfactant extract (CLSE). Emphasis was on defining the relative importance of lung surfactant phospholipids (PPL), neutral lipids (N), and hydrophobic proteins (SP) in facilitating dynamic respreading and surface tension lowering within the interfacial film itself. Solvent-spread films in a Wilhelmy balance were studied at 23° and 37°C over a range of cycling rates for initial concentrations giving both monomolecular and surface-excess films. A striking finding was that PPL films containing the complete mix of surfactant phospholipids had greatly improved dynamic respreading corn, pared to DPPC, particularly surface ...
Insufficient production of pulmonary surfactant in alveolar type II cells is relevant to many lung diseases. To cure its deficiency, glucocorticoid is commonly used in clinical areas. In the present study, we investigated the effect of dexamethasone on the secretion of phosphatidylcholine, a major phospholipid of pulmonary surfactant, in a primary culture of rat alveolar type II cells. Dexamethasone had no effect on the basal secretion rate of phosphatidylcholine. Dexamethasone augmented both the phosphatidylcholine secretion and the cyclic AMP formation increased by terbutaline. Furthermore, dexamethasone increased the number of β-adrenoceptors and mRNA expression of β,SUB,2,/SUB,-adrenoceptors in type II cells. These findings indicate that dexamethasone increases pulmonary surfactant secretion through an enhancement of β,SUB,2,/SUB,-adrenoceptor gene expression.. ...
Figure S1: Low donor lung SP-A mRNA-level associates with decreased survival. The graph shows the survival curves for recipients of double lung transplant excluding patient with ILD. This ad hoc analysis was to address the possible selection bias that is shown in Table S1 with greater percentage of ILD and single lung transplant in the study cohort. Lung transplant patients that received lung allografts with low levels of SP-A mRNA expression prior to implantation had significantly reduced survival. The number of patients in each group is indicated in brackets. The x-axis represents the cumulative survival. Circles indicate the censored patients within the analysis. ...
Biotin偶联Surfactant protein D抗体[IIE11](ab15695)可与大鼠, 人样本反应并经WB, IHC实验严格验证,被2篇文献引用,实验条件参看说明书。中国75%以上现货。
Nanostructure Changes in Lung Surfactant Monolayers Induced by Interactions between Palmitoyloleoylphosphatidylglycerol and Surfactant Protein B Junqi Ding, Ivo Doudevski, Heidi E. Warriner, Timothy Alig, and Joseph A. Zasadzinski. What does a lung surfactant do?. Forms a monolayer Slideshow...
An aqueous structured surfactant composition contains an anionic surfactant selected from isethionate surfactants, taurate surfactants, and sarcosinate surfactants, and mixtures thereof, and an electr
What is Surfactant? The alveoli contain many types of cells. Among them Type 2 Pneumocytes produces surfactant. The main function of surfactant is to reduce surface tension, so that decrease the work of breathing. Surfactant forms a thin monomolecular layer at the air fluid interface. Surfactant layer is not static. It is continuously secreting and reabsorbing. Deficiency of surfactant causes Respiratory …. Read More » ...
Recombinant surfactant protein A and pharmaceutical compositions based thereon are useful for the prevention or treatment of pulmonary infection and inflammation.
Surfactant, substance such as a detergent that, when added to a liquid, reduces its surface tension, thereby increasing its spreading and wetting properties. In the dyeing of textiles, surfactants help the dye penetrate the fabric evenly. Learn more about surfactants in this article.
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RPB039Hu01, Recombinant Surfactant Associated Protein D (SPD), 表面活性物质关联蛋白D(SPD)重组蛋白, SFTPD; COLEC7; PSP-D; SFTP4; SP-D; Pulmonary Surfactant Protein D; Collectin-7; Lung surfactant protein D | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Other research interest include; pulmonary surfactant subtype conversion, alterations of pulmonary surfactant in acute respiratory distress syndrome, the use of surfactant supplementation for the treatment of acute respiratory Distress Syndrome and pulmonary surfactant in lung transplantation. Most of these studies are done in collaboration with Drs Lewis, Possmayer and Novick.. Publications. Lewis JF, Veldhuizen RA. The Future of Surfactant Therapy during ALI/ARDS. Semin Respir Crit Care Med. 2006 Aug;27(4):377-88.. Bailey TC, Maruscak AA, Petersen A, White S, Lewis JF, Veldhuizen RA. Physiologic effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein-A. Am J Physiol Lung Cell Mol Physiol. 2006 Apr 21; [Epub ahead of print]. Huang W, McCaig LA, Veldhuizen RA, Yao LJ, Lewis JF. Mechanisms responsible for surfactant changes in sepsis-induced lung injury. Eur Respir J. 2005 Dec;26(6):1074-9.. Da Silva K, McCaig LA, Veldhuizen RA, Possmayer F. Protein ...
Other research interest include; pulmonary surfactant subtype conversion, alterations of pulmonary surfactant in acute respiratory distress syndrome, the use of surfactant supplementation for the treatment of acute respiratory Distress Syndrome and pulmonary surfactant in lung transplantation. Most of these studies are done in collaboration with Drs Lewis, Possmayer and Novick.. Publications. Lewis JF, Veldhuizen RA. The Future of Surfactant Therapy during ALI/ARDS. Semin Respir Crit Care Med. 2006 Aug;27(4):377-88.. Bailey TC, Maruscak AA, Petersen A, White S, Lewis JF, Veldhuizen RA. Physiologic effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein-A. Am J Physiol Lung Cell Mol Physiol. 2006 Apr 21; [Epub ahead of print]. Huang W, McCaig LA, Veldhuizen RA, Yao LJ, Lewis JF. Mechanisms responsible for surfactant changes in sepsis-induced lung injury. Eur Respir J. 2005 Dec;26(6):1074-9.. Da Silva K, McCaig LA, Veldhuizen RA, Possmayer F. Protein ...
Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment of cryptococcosis, the mortality rate is approximately 12% in medically advanced countries, and approaches 50% in less developed regions. Additionally, ,italic,C. neoformans,/italic, can cause infection in seemingly healthy individuals, elevating its status as a primary human pathogen. Although numerous studies have examined virulence properties, less is understood regarding host immune factors in the lungs during early stages of fungal infection. In the present thesis studies, I examined the roles played by pulmonary surfactant proteins in response to ,italic,C. neoformans in vitro,/italic, and ,italic,in vivo,/italic,. We demonstrate that SP-D, but not SP-A, binds to the yeast and increases phagocytosis of poorly encapsulated yeast cells by macrophages, yet concomitantly protects the ...
Adaptation to respiration at birth depends upon the synthesis of pulmonary surfactant, a lipid-protein complex that reduces surface tension at the air-liquid interface in the alveoli and prevents lung collapse during the ventilatory cycle. Herein, we demonstrated that the gene encoding a subunit of the endoplasmic reticulum membrane complex, EMC3, also known as TMEM111 (Emc3/Tmem111), was required for murine pulmonary surfactant synthesis and lung function at birth. Conditional deletion of Emc3 in murine embryonic lung epithelial cells disrupted the synthesis and packaging of surfactant lipids and proteins, impaired the formation of lamellar bodies, and induced the unfolded protein response in alveolar type 2 (AT2) cells. EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3. Transcriptomic, lipidomic, and proteomic analyses demonstrated that EMC3 coordinates the assembly of lipids and proteins in ...
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Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate immunity. The proteins are host defense lectins, belonging to the collectin family which also... ...